Associations of exposure to multiple metals with the risk of age-related cataract in Anhui, China: a case–control study - Yan-Qing Li; Qian Wang; Ran Liu; Guo-Ao Li; Jia-Liu He; Fen Huang; Yan-Feng Zhou (Environmental Science and Pollution Research, 2023)

OsPPR11 encoding P-type PPR protein that affects group II intron splicing and chloroplast development - Qiang Zhang; Changzhao Chen; Yaliang Wang; Mengxing He; Zhiwen Li; Lan Shen; Qing Li; Li Zhu; Deyong Ren; Jiang Hu; Zhenyu Gao; Guangheng Zhang; et al. (Plant Cell Reports, 2022)

Highly efficient removal of hexavalent chromium by magnetic Fe–C composite from reed straw and electric furnace dust waste - Fu-Ping Wang; Ya-Nan Zeng; Yi-Tong Wang; Jun-Guo Li; Xi Zhang; Ai-Min Ji; Le-Le Kang; Rui Ji; Qing Yu; Di Gao; Xiao-Man Wang; Zhen Fang (Environmental Science and Pollution Research, 2022)

Efficacy and Safety of Recombinant Human Prourokinase in Acute Ischemic Stroke: A Phase IIa Randomized Clinical Trial - Haiqing Song; Yuan Wang; Qingfeng Ma; Huisheng Chen; Bo Liu; Yi Yang; Jianguo Zhu; Shigang Zhao; Xiaoping Jin; Yongqiu Li; Yanyong Wang; Runxiu Zhu; et al. (Translational Stroke Research, 2022)

Association Between Regular Blood Pressure Monitoring and the Risk of Intracranial Aneurysm Rupture: a Multicenter Retrospective Study with Propensity Score Matching - Ping Zhong; Zhiwen Lu; Tianxiao Li; Qing Lan; Jianmin Liu; Zhanxiang Wang; Sifang Chen; Qinghai Huang (Translational Stroke Research, 2022)

Identification of a stable major-effect quantitative trait locus for pre-harvest sprouting in common wheat (Triticum aestivum L.) via high-density SNP-based genotyping - Zhi Li; Yongyan Chen; Xia Ou; Mengning Wang; Nanxin Wang; Wei Li; Yawen Deng; Yixin Diao; Zixin Sun; Qinyi Luo; Xinli Li; Liqi Zhao; et al. (Theoretical and Applied Genetics, 2022)

The landscape of aging - Yusheng Cai; Wei Song; Jiaming Li; Ying Jing; Chuqian Liang; Liyuan Zhang; Xia Zhang; Wenhui Zhang; Beibei Liu; Yongpan An; Jingyi Li; Baixue Tang; et al. (Science China Life Sciences, 2022)

Study on Failure Characteristics of Stemming Structure on Iron Ore Under Blasting Load - Xinmin Ma; Guoliang Yang; Jinjing Zuo; Yanbing Wang; Yuan Jin; Qing Li (Rock Mechanics and Rock Engineering, 2022)

The effect of growth stage and plant counting accuracy of maize inbred lines on LAI and biomass prediction - Yingpu Che; Qing Wang; Long Zhou; Xiqing Wang; Baoguo Li; Yuntao Ma (Precision Agriculture, 2022)

Evidence in Support of Analogical Reasoning Improvements with Executive Attention Intervention in Healthy Young Adults - Yixuan Lin; Qing Li; Mengke Zhang; Yujie Su; Xiangpeng Wang; Hong Li; Antao Chen (Neuroscience Bulletin, 2022)

SIRT1 regulates mitotic catastrophe via autophagy and BubR1 signaling - Weiwei Zhao; Qing Wang; Le Li; Chengshen Xie; Yequn Wu; Mayank Gautam; Lijia Li (Molecular and Cellular Biochemistry, 2022)

Inhibition of Microglial NLRP3 with MCC950 Attenuates Microglial Morphology and NLRP3/Caspase-1/IL-1β Signaling In Stress-induced Mice - Qing Liu; Man-Man Zhang; Min-Xia Guo; Qiu-Ping Zhang; Na-Zhi Li; Jie Cheng; Shi-Le Wang; Guang-Hui Xu; Cheng-Fu Li; Ji-Xiao Zhu; Li-Tao Yi (Journal of Neuroimmune Pharmacology, 2022)

Comparative transcriptome and adaptive evolution analysis on the main liver and attaching liver of Pareuchiloglanis macrotrema - Qing Wu; Xiaoyang Zhang; Jie Li; Longjun Deng; Dongjie Wang; Min Liao; Zhonggang Guo; Xiaoli Huang; Defang Chen; Yan Wang; Shiyong Yang; Zongjun Du; et al. (Journal of Applied Genetics, 2022)

Comparison of infections with respiratory syncytial virus between children and adults: a multicenter surveillance from 2015 to 2019 in Beijing, China - Ming Luo; Cheng Gong; Yan Zhang; Xue Wang; Yang Liu; Qing Luo; Maozhong Li; Aihua Li; Yiting Wang; Mei Dong; Wenbo Xu; Fang Huang (European Journal of Clinical Microbiology & Infectious Diseases, 2022)

Implications of the discovery of rapidly deposited lacustrine sediments in the Suwalong reach of the upper Jinsha River, SE Tibetan Plateau - Yongchao Li; Jianping Chen; Chun Tan; Feifan Gu; Yiwei Zhang; Muhammad Ammar; Qing Wang (Bulletin of Engineering Geology and the Environment, 2022)

Correction to: Behavioral and brain functional characteristics of children with attention-defcit/hyperactivity disorder and anxiety trait - Zhao-Min Wu; Peng Wang; Juan Liu; Lu Liu; Xiao-Lan Cao; Li Sun; Qing-Jiu Cao; Li Yang; Yu-Feng Wang; Bin-Rang Yang (Brain Imaging and Behavior, 2022)

Behavioral and brain functional characteristics of children with Attention-Deficit/Hyperactivity disorder and anxiety trait - Zhao-Min Wu; Peng Wang; Juan Liu; Lu Liu; Xiao-Lan Cao; Li Sun; Qing-Jiu Cao; Li Yang; Yu-Feng Wang; Bin-Rang Yang (Brain Imaging and Behavior, 2022)

Immunogenicity and protective efficacy of a DNA vaccine inducing optimal expression of the SARS-CoV-2 S gene in hACE2 mice - Zhuo-xin Li; Sheng Feng; He Zhang; Xin-yu Zhuang; Chao Shang; Shi-yu Sun; Ji-cheng Han; Yu-biao Xie; Jin-yong Zhang; Wei Wang; Cheng-hui Li; Guan-yu Zhao; et al. (Archives of Virology, 2022)

Exploring the Wenchuan earthquake fault through the accurate location of WFSD-4# Well using seismic reflection - Yang-Yang Feng; Chang-Qing Yu; Hai-Bing Li; Chen Qu; Chan Wu; Qi Wang; Su Luo; Jin-Peng Huang; Ghazi Rehana (Applied Geophysics, 2022)

Molecular cloning and characterisation of the PmEglin cDNA in the leech Hirudinaria sp. - Bo-Xing Cheng; Gui-Yan Shao; Yuan Li; Qing-Qing Tian; Su-Yan Wang; Fei Liu (Biologia, 2022)

High-temperature exposure and risk of spontaneous abortion during early pregnancy: a case–control study in Nanjing, China - Shuangshuang Zhao; Jie Xu; Wen Li; Yingying Lu; Linxiang Huang; Haoyi Xu; Mingxia Shi; Yan Wang; Qiaoying Zhu; Qing Xu (Environmental Science and Pollution Research, 2022)

PITPNC1 promotes the thermogenesis of brown adipose tissue under acute cold exposure - Guoqing Tang; Chengxin Ma; Liangkui Li; Shaoyan Zhang; Fengsheng Li; Jin Wu; Yesheng Yin; Qing Zhu; Yan Liang; Ru Wang; He Huang; Tong-Jin Zhao; et al. (Science China Life Sciences, 2022)
Brown adipose tissue (BAT) plays an essential role in non-shivering thermogenesis. The phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) is identified as a lipid transporter that reciprocally transfers phospholipids between intracellular membrane structures. However, the physiological significance of PITPNC1 and its regulatory mechanism remain unclear. Here, we demonstrate that PITPNC1 is a key player in thermogenesis of BAT. While Pitpnc1 −/− mice do not differ with wildtype mice in body weight and insulin sensitivity on either chow or high-fat diet, they develop hypothermia when subjected to acute cold exposure at 4°C. The Pitpnc1 −/− brown adipocytes exhibit defective β-oxidation and abnormal thermogenesis-related metabolism pathways in mitochondria. The deficiency of lipid mobilization in Pitpnc1 −/− brown adipocytes might be the result of excessive accumulation of phosphatidylcholine and a reduction of phosphatidic acid. Our findings have uncovered significant roles of PITPNC1 in mitochondrial phospholipid homeostasis and BAT thermogenesis.

Improving the efficiency of prime editing with epegRNAs and high-temperature treatment in rice - Jinpeng Zou; Xiangbing Meng; Qing Liu; Meiqi Shang; Kejian Wang; Jiayang Li; Hong Yu; Chun Wang (Science China Life Sciences, 2022)

A1 Adenosine Receptor Activation Inhibits P2X3 Receptor–Mediated ATP Currents in Rat Dorsal Root Ganglion Neurons - Jia-Wei Hao; Wen-Long Qiao; Qing Li; Shuang Wei; Xue-Mei Li; Ting-Ting Liu; Chun-Yu Qiu; Wang-Ping Hu (Molecular Neurobiology, 2022)

CAF-derived midkine promotes EMT and cisplatin resistance by upregulating lncRNA ST7-AS1 in gastric cancer - Ke-Da Yang; Ying Wang; Fan Zhang; Qing-Ling Li; Bai-Hua Luo; De-Yun Feng; Zhi-Jun Zeng (Molecular and Cellular Biochemistry, 2022)

Study on Critical Safety Distance Between the Shield Tunnel and Front Fault Fracture Zone in Urban Metro - Liping Li; Yizhe Han; Jing Wang; Qing Jin; Yifan Xiong; Jixin Chong; Xingzhi Ba; Zhongdong Fang; Kai Wang (Geotechnical and Geological Engineering, 2022)

PPCPs and heavy metals from hydrothermal sewage sludge-derived biochar: migration in wheat and physiological response - Kai Zhen; Qing Zhu; Sheng Zhai; Yue Gao; Huimin Cao; Xuejiao Tang; Cuiping Wang; Jiao Li; Lili Tian; Hongwen Sun (Environmental Science and Pollution Research, 2022)

The key role of hydrophobicity in the determination of pharmaceuticals by liquid chromatography–electrospray ionization-mass spectrometry under the interference of natural organic matter - Zheng Wang; Aimin Li; Yufeng Liao; Chendong Shuang; Yang Pan; Yangyang Zhang; Hongfang Sun; Qing Zhou; Wentao Li (Environmental Science and Pollution Research, 2022)

Activation of peroxymonosulfate by modified coagulation sludge for bisphenol A degradation - Jie Bai; Yihui Li; Bowen Song; Qing Wang (Environmental Science and Pollution Research, 2022)

mTORC1/C2 regulate spermatogenesis in Eriocheir sinensis via alterations in the actin filament network and cell junctions - Zhen-Fang Li; Shuang-Li Hao; Lan-Min Wang; Hong-Yu Qi; Jia-Ming Wang; Fu-Qing Tan; Wan-Xi Yang (Cell and Tissue Research, 2022)

Paenibacillus hamazuiensis sp. nov., a bacterium isolated from Hamazui hot spring in Yunnan province, south-west China - Juan Wang; Ming Deng; En-Min Zhou; Lei Ran; Cui-Ping Miao; Yi-Qing Li; Jun-Mei Ding; Shu-Kun Tang (Archives of Microbiology, 2022)

Starvation shrinks the mussel foot secretory glands and impairs the byssal attachment - Yi Zheng; Yue-Ming Yang; Yue-Feng Xu; Yu-Qing Wang; Xue Shi; Gao-Hai Zheng; Yi-Feng Li (Frontiers in Marine Science, 2022)
Mussel is an economically and ecologically important species widely distributed throughout the world. The mussel adheres to the attachment substrate by secreting byssus external to the body. Various environmental and biological factors influence the process of byssus secretion, and the present study investigated the effect of starvation on byssal secretion in the hard-shelled mussel Mytilus coruscus . Histological changes in mussel foot secretory glands and gene expression of mussel foot proteins were also determined. The experimental setup consisted of starvation treatments for 7, 14 and 21 days, and the control groups. The results showed that the number of produced byssus was higher in the starvation group compared to the control (CTR) group, and the starvation group had a significantly higher of byssal shedding number from 6 days of starvation treatment onwards ( p < 0.05). The byssal thread diameter was significantly reduced in all starvation treatment groups ( p < 0.05). However, starvation treatment had no effect on the length of the byssal thread ( p > 0.05). After 21 days of starvation treatment, the byssal thread volume was significantly lower than that of the CTR group ( p < 0.05). A significant decrease in the breaking force of the byssal thread was observed after 14 and 21 days of starvation treatment ( p < 0.05), along with an upward shift in the breakpoints. Starvation treatment significantly reduced the percentage of foot secretory glands area to total tissue ( p < 0.05). The expression of the mussel foot protein genes ( Mcfp-1P and Mcfp-1T ) was significantly up-regulated at 7 days of starvation treatment ( p < 0.05). These findings reveal that starvation weakens byssal thread performance by influencing mussel foot secretory glands, which increases the dislodgment risks of suspended-cultured mussels.

Preparation of Pinocembrin-Loaded F127/MPEG-PDLLA Polymer Micelles and Anti-Osteoporotic Activity - Xia Cao; Qing He; Michael Adu-Frimpong; Xinyi Shen; Wanjing Rong; Xiaoxiao Li; Jian Zhang; Xiaoli Xia; Feng Shi; Hao Ji; Elmurat Toreniyazov; Qilong Wang; et al. (AAPS PharmSciTech, 2022)

The association between short-term ambient sulfur dioxide exposure and hospitalization costs of ischemic stroke: a hospital-based study in Chongqing, China - En-Jie Tang; Yu-Meng Zhou; Li-Li Yang; Nan Wang; Yue-Xu Jiang; Hua Xiao; Yue-Gu Hu; Da-Wei Li; Na Li; Qing-Song Huang; Ning Du; Ya-Fei Li; et al. (Environmental Science and Pollution Research, 2022)

Two new aromatic derivatives from Codonopsis pilosula and their α-glucosidase inhibitory activities - Ru-Yue Wang; Pan-Jie Su; Bing Li; Xiao-Qing Zhan; Feng-Ming Qi; Chun-Wei Lv; Fang-Di Hu; Kun Gao; Zhan-Xin Zhang; Dong-Qing Fei (Natural Product Research, 2022)

Complete chloroplast genomes of two medicinal Swertia species: the comparative evolutionary analysis of Swertia genus in the Gentianaceae family - Qing Du; Jing Li; Liqiang Wang; Haimei Chen; Mei Jiang; Zhuoer Chen; Chuanbei Jiang; Haidong Gao; Bin Wang; Chang Liu (Planta, 2022)

SLAH1 is involved in the long-distance transport of Cl− from roots into shoots in the Cl−-tolerant xerophyte Pugionium cornutum under salt stress - Yan-Nong Cui; Xiao-Yu Li; Rui-Wen Liu; Zi-Hua He; Suo-Min Wang; Qing Ma (Plant and Soil, 2022)

Starch, cellulose and plant extracts as green inhibitors of metal corrosion: a review - Li Huang; Wei-Qiang Chen; Shan-Shan Wang; Qing Zhao; Hui-Jing Li; Yan-Chao Wu (Environmental Chemistry Letters, 2022)

Screening for SH3TC2 variants in Charcot–Marie–Tooth disease in a cohort of Chinese patients - Bo Sun; Zheng-Qing He; Yan-Ran Li; Jiong-Ming Bai; Hao-Ran Wang; Hong-Fen Wang; Fang Cui; Fei Yang; Xu-Sheng Huang (Acta Neurologica Belgica, 2022)

Dynamic effects of short-term exercise on muscle texture and gut flora in the hybrid (Megalobrama amblycephala♀ × Ancherythroculter nigrocauda♂) - Huijie Wei; Lang Zhang; Qing Li; Yali Yu; Yanhong Sun; Ziwei Song; Pei Li; Tao Mao; Jian Chen; Li He; Guiying Wang (Frontiers in Marine Science, 2022)
Fillet texture plays a significant role in consumer acceptance, which heavily influenced by exercise according to previous studies. “Xianfeng No. 2”, a novel hybrid of Megalobrama amblycephala ( M. amblycephala ) (♀) and Ancherythroculter nigrocauda ( A. nigrocauda ) (♂), with characteristics of quick growth, good disease resistance, and anti-stress capability, is one of an important aquaculture fish species in China, however, the ways to improve fillet quality in this species remains unknown. In this study, a short-term exercise trial (0-16d), hematoxylin and eosin (H&E) staining, and texture analysis were carried out to determine the effects of exercise on muscle cellularity and texture. Furthermore, 16S rRNA analysis was performed to determine the impacts of exercise on the intestinal microbiota. Compared with non-exercised group (0d), exercised groups showed influences in muscle cellularity (decreased muscle fiber diameter and increased muscle fiber density) and improvements in muscle texture (increased hardness, cohesiveness, gumminess, and chewiness). In addition, 16S rRNA sequencing analysis exhibited that short-term exercise could significantly increase the community richness and diversity, as well as alter the composition of gut microflora in this hybrid species. At the level of phylum, the relative richness of Proteobacteria , Firmicutes , Bacteroidetes , and Fusobacteria changed remarkably after short-term exercise. At the level of genus, the relative richness of Pseudomonas , Acinetobacter , Stenotrophomonas , Alpinimonas , Rhodococcus , Shewanella , Brevundimonas changed significantly, suggested that short-term swimming exercise might increase intrinsic antimicrobial resistance and promote denitrification capacity of this hybrid species. Furthermore, a LEfSe analysis of intestinal microflora communities illustrated that Pseudomonas and MNG7 may be utilized to distinguish between exercised and non-exercised fish. Our research, collectively, found an effective way to improve fillet texture by exercise, revealed the impacts of exercise on the intestinal microbiota, further expanded our knowledge of fish under exercise.

Transcriptome Analysis of Greenfin Horse-Faced Filefish (Thamnaconus septentrionalis) Gills in Response to Amyloodinium ocellatum (AO) Infection - Li-Guo Yang; Yue Wang; Wen-Bin Xu; Bo Qin; Na Ying; Xue-Feng Song; Yan-Feng Yue; Xiao-Shan Wang; Bian-Bian Zhang; Yan-Qing Wu (Fishes, 2022)
The greenfin horse-faced filefish (Thamnaconus septentrionalis) is susceptible to recurrent Amyloodinium ocellatum (AO) infestation over the grow-out production cycle. This parasite breeds mainly on the gills, causing hypoxia in the fish body, and leading to many deaths. The host-parasite response drives a complex immune reaction, which is poorly understood. To generate a model for host-parasite interaction and the pathogenesis of AO in greenfin horse-faced filefish, an RNA-seq approach, differential gene expression, GO, and KEGG analyses were employed. Overall, 624 new genes and 2076 differentially expressed genes (DEGs) were detected, including 942 upregulated and 1134 downregulated genes in the gills. Compared with the control group, the expression of leptin a, GTPase IMAP family member 4, and NLR family CARD domain-containing protein 3 was significantly higher in the AO-infected group. Conversely, cell wall integrity and stress response component 1-like, and hepcidin-like were significantly downregulated in the gills of AO-infected fish. GO and KEGG enrichment analysis indicated that DEGs were significantly enriched in signaling pathways associated with viral protein interaction with cytokine and cytokine receptor and cytokine–cytokine receptor interaction. Collectively, this transcriptomic study provides novel molecular insights into the pathology caused by AO infestation and alternative theories for future research implementing strategies to control and manage AO.

Effect modification by aging on the associations of nicotine exposure with cognitive impairment among Chinese elderly - Jian Hou; Chao Huang; Bo Zhu; Wei Liu; Qing-qing Zhu; Lu Wang; Tian Li; Chun-jie Yuan; Shao-yang Lai; De-sheng Wu; Fei-qi Zhu; Jia-fei Zhang; et al. (Environmental Science and Pollution Research, 2022)

Truncated analog Brevinin2-CE-N26V5K: Revelation the Augmentation of Antimicrobial Activity - Yi Zhao; Xiao-yan Wang; Yan Sun; Zhi Li; Tao Liu; Qing-mei Liu; Jingyi Chen (World Journal of Microbiology and Biotechnology, 2022)

Wheat genomic study for genetic improvement of traits in China - Jun Xiao; Bao Liu; Yingyin Yao; Zifeng Guo; Haiyan Jia; Lingrang Kong; Aimin Zhang; Wujun Ma; Zhongfu Ni; Shengbao Xu; Fei Lu; Yuannian Jiao; et al. (Science China Life Sciences, 2022)

Mechanisms underlying microRNA-222-3p modulation of methamphetamine-induced conditioned place preference in the nucleus accumbens in mice - Qing Shang; Jing Wang; Zhijia Xi; Baoyao Gao; Hongyan Qian; Ran An; Gaojie Shao; Hua Liu; Tao Li; Xinshe Liu (Psychopharmacology, 2022)

Two new clerodane diterpenoids and a new pyran-2-one derivative with anti-neuroinflammatory activities from Croton crassifolius - Zhi-Peng Ling; Qing Tang; Can-Jie Li; Jin-Lin Tan; Hai-Yue Zhao; Yi-Kun Hao; Zhao-Chun Zhan; Zhong-Nan Wu; Yu-Bo Zhang; Qing Zheng; Guo-Cai Wang (Journal of Natural Medicines, 2022)

Catalytic effect of cesium on the oxidation behavior of cation exchange resins in Li2CO3-Na2CO3-K2CO3 melt - Yang-Hai Zheng; Yong-De Yan; Yun Xue; Yue-Lin Wang; Xin Liu; Wan-Sheng Mi; Qing-Guo Zhang; Yu Li; Fu-Qiu Ma; Mi-Lin Zhang; Zhi-Hao Gan; Kai Zhu (Environmental Science and Pollution Research, 2022)

Assessment of microbial α-diversity in one meter squared topsoil - Shuzhen Li; Xiongfeng Du; Kai Feng; Yueni Wu; Qing He; Zhujun Wang; Yangying Liu; Danrui Wang; Xi Peng; Zhaojing Zhang; Arthur Escalas; Yuanyuan Qu; et al. (Soil Ecology Letters, 2022)

Ensemble forecast of tropical cyclone tracks based on deep neural networks - Chong Wang; Qing Xu; Yongcun Cheng; Yi Pan; Hong Li (Frontiers of Earth Science, 2022)

Starch accumulation dynamics and transcriptome analysis of Chlorella sorokiniana during transition of sulfur nutritional status - Haiqing Xu; Jinzhi Yang; Xu Wang; Qing Peng; Yanxia Han; Xudong Liu; Kexin Liu; Shijuan Dou; Liyun Li; Guozhen Liu; Ming Yang (Frontiers in Marine Science, 2022)
Microalgae can effectively accumulate starch by using nutritional limitation methods in the context of bioalcohol fuel production. However, relatively few studies have focused on starch accumulation in microalgae and its molecular basis, especially under sulfur limitation conditions. In this study, the starch accumulation dynamics and physiological responses of Chlorella sorokiniana under sulfur starvation (SS) and sulfur replenishment (SR) conditions were investigated, and the genes involved in the transcriptional regulation were explored using RNA-seq. The starch content in C. sorokiniana cells significantly increased from 1.6% to 55.0% of dry weight within 24 h under SS conditions, and then, it decreased to 3.4% within 12 h after transition to SR conditions. However, cell growth was inhibited, and pigment content decreased under SS conditions. Using RNA-seq analysis, a total of 9720 differentially expressed genes (DEGs) induced by sulfur status were obtained. These genes were narrowed down to 454 starvation and replenishment cross-validated (SRV)-DEGs, among which 283 SRV-DEGs were significantly up-regulated and 171 SRV-DEGs were down-regulated under SS conditions, and returned to their previous state under SR conditions. The SRV-DEGs enriched in the sulfate metabolism pathway were all up-regulated under SS conditions after 6 h to speed up the sulfur metabolic cycle, and the transcriptional abundance of a sulfate transporter (SULTR4), cysteine synthase[O-acetylserine(thiol)-lyase] (OASTL), serine acetyltransferase (SAT), and methanethiol oxidase (SELENBP1) increased 8.6-fold, 12.6-fold, 8.7-fold, and 12.4-fold, respectively. Protein synthesis was correspondingly inhibited, which resulted in the reallocation of carbon and elevated the starch synthesis pathway, in which the expressions of glycogen branching enzyme (GBE) and starch synthase (SS) were up-regulated 12.0- and 3.0-fold, respectively. The fatty acid desaturase (FAD) and phosphatidic acid phosphatase (PAP) in the lipid synthesis pathway were strongly up-regulated 8.8- and 16.2-fold, respectively, indicating the competitive synthesis of lipids. The down-regulation of SRV-DEGs associated with carbon fixation, such as those in the Calvin cycle, possibly affected cell growth. The time-resolved transcriptional analysis identified the SRV-DEGs, revealing the underlying starch accumulation mechanism, as well as the relationship with cell growth and lipid synthesis.

Intestinal Models for Personalized Medicine: from Conventional Models to Microfluidic Primary Intestine-on-a-chip - Xiang-Guang Li; Ming-xia Chen; Su-qing Zhao; Xiu-qi Wang (Stem Cell Reviews and Reports, 2022)

Canagliflozin mitigates ferroptosis and ameliorates heart failure in rats with preserved ejection fraction - Sai Ma; Li-Li He; Guo-Rui Zhang; Qing-Juan Zuo; Zhong-Li Wang; Jian-Long Zhai; Ting-Ting Zhang; Yan Wang; Hui-Juan Ma; Yi-Fang Guo (Naunyn-Schmiedeberg's Archives of Pharmacology, 2022)
Recently, hypoglycemic drugs belonging to sodium-glucose cotransporter 2 inhibitors (SGLT2i) have generated significant interest due to their clear cardiovascular benefits for heart failure with preserved ejection fraction (HFpEF) since there are no effective drugs that may improve clinical outcomes for these patients over a prolonged period. But, the underlying mechanisms remain unclear, particularly its effects on ferroptosis, a newly defined mechanism of iron-dependent non-apoptotic cell death during heart failure (HF). Here, with proteomics, we demonstrated that ferroptosis might be a key mechanism in a rat model of high-salt diet-induced HFpEF, characterized by iron overloading and lipid peroxidation, which was blocked following treatment with canagliflozin. Data are available via ProteomeXchange with identifier PXD029031. The ferroptosis was evaluated with the levels of acyl-CoA synthetase long-chain family member 4, glutathione peroxidase 4, ferritin heavy chain 1, transferrin receptor, Ferroportin 1, iron, glutathione, malondialdehyde, and 4-hydroxy-trans-2-nonenal. These findings highlight the fact that targeting ferroptosis may serve as a cardioprotective strategy for HFpEF prevention and suggest that canagliflozin may exert its cardiovascular benefits partly via its mitigation of ferroptosis.

RNAi-Based Transcriptome Suggests Candidate Genes Regulated by ZxNHX1 to Affect The Salt Tolerance of Zygophyllum xanthoxylum - Hai-Shuang Liu; Xiao-Nong Guo; Wei-Wei Chai; Rui-Xin Zhang; Pei-Qin Li; Cui-Min Ma; Qing Ma; Suo-Min Wang (Journal of Plant Growth Regulation, 2022)

MdMYB88/124 modulates apple tree microRNA biogenesis through post-transcription processing and/or transcription pathway - Chun-dong Niu; Huan-ran Shi; Zi-tong Zhang; Tian-le Fan; Huan Dang; Peng-xiang Chen; Yin-peng Xie; Cha-na Bao; Feng-wang Ma; Qing-mei Guan; Xue-wei Li (Acta Physiologiae Plantarum, 2022)

More soil organic carbon is sequestered through the mycelium pathway than through the root pathway under nitrogen enrichment in an alpine forest - Xiaomin Zhu; Ziliang Zhang; Qitong Wang; Josep Peñuelas; Jordi Sardans; Hans Lambers; Na Li; Qing Liu; Huajun Yin; Zhanfeng Liu (Global Change Biology, 2022)
Plant roots and associated mycorrhizae exert a large influence on soil carbon (C) cycling. Yet, little was known whether and how roots and ectomycorrhizal (ECM) extraradical mycelia differentially contribute to soil organic C (SOC) accumulation in alpine forests under increasing nitrogen (N) deposition. Using ingrowth cores, the relative contributions of the root pathway (RP; i.e., roots and rhizosphere processes) and mycelium pathway (MP; i.e., extraradical mycelia and hyphosphere processes) to SOC accumulation were distinguished and quantified in an ECM‐dominated forest receiving chronic N addition (25 kg N ha −1 year −1 ). Under the non‐N addition, the RP facilitated SOC accumulation, although the MP reduced SOC accumulation. Nitrogen addition enhanced the positive effect of RP on SOC accumulation from +18.02 to +20.55 mg C g −1 but counteracted the negative effect of MP on SOC accumulation from −5.62 to −0.57 mg C g −1 , compared with the non‐N addition. Compared with the non‐N addition, the N‐induced SOC accumulation was 1.62–2.21 and 3.23–4.74 mg C g −1 , in the RP and the MP, respectively. The greater contribution of MP to SOC accumulation was mainly attributed to the higher microbial C pump (MCP) efficacy (the proportion of increased microbial residual C to the increased SOC under N addition) in the MP (72.5%) relative to the RP (57%). The higher MCP efficacy in the MP was mainly associated with the higher fungal metabolic activity (i.e., the greater fungal biomass and N‐acetyl glucosidase activity) and greater binding efficiency of fungal residual C to mineral surfaces than those of RP. Collectively, our findings highlight the indispensable role of mycelia and hyphosphere processes in the formation and accumulation of stable SOC in the context of increasing N deposition.

Transition between Mycobacterium tuberculosis and nontuberculous mycobacteria in recurrent “tuberculosis” patients - Qing Li; Haoran Li; Jun An; Xuxia Zhang; Wei Wang; Yufeng Wang; Zhongtan Xue; Shanshan Li; Yu Pang (European Journal of Clinical Microbiology & Infectious Diseases, 2022)

Spatial-temporal distribution and tectonic setting of Mesozoic W-mineralized granitoids in the Xing-Meng Orogenic Belt, NE China - Wei Xie; Qing-Dong Zeng; Rui-Liang Wang; Jin-Jian Wu; Zhe-Ming Zhang; Feng-Chun Li; Zhuang Zhang (International Geology Review, 2022)

Three new sesquiterpene lactones from the whole plants of Elephantopus scaber - Ding-Chai Lin; Qing Tang; Xue-Fang Zhuo; Wen-Zhi Wang; Can-Jie Li; Guang-Kai Kuang; Zhong-Nan Wu; Yu-Bo Zhang; Guo-Cai Wang; Yao-Lan Li (Natural Product Research, 2022)

Retrieval of Remotely Sensed Sediment Grain Size Evolution Characteristics along the Southwest Coast of Laizhou Bay Based on Support Vector Machine Learning - Xiang Yu; Chao Zhan; Yan Liu; Jialin Bi; Guoqing Li; Buli Cui; Longsheng Wang; Xianbin Liu; Qing Wang (Journal of Marine Science and Engineering, 2022)
Grain size is the basic property of intertidal zone sediment. Grain size acts as an indicator of sedimentary processes and geomorphological evolution under human and nature interactions. The remote sensing technique provides an alternative for sediment grain-size parameter monitoring with the advantages of wide coverage and real-time surveying. This paper attempted to map the distributions of three sediment grain size contents and the mean grain size with multitemporal Landsat images along the southwestern coast of Laizhou Bay, China, from 1989 to 2015. Considering the low correlations between the measured reflectance and grain-size parameters, we used a support vector machine (SVM) to develop a nonlinear calibration model by taking several band indices as input variables. Then, the performance of the back propagation neural network (BPNN) was determined and discussed with that of the SVM. The SVM performed better than the BPNN in calibrating the four grain-size parameters based on a comparison of R2 and the root-mean-square error (RMSE). Moreover, an atmospheric correction algorithm originally proposed for case II water enabled the TM\ETM+ images to be precisely atmospherically corrected in this study. The SVM-mapped spatial-temporal grain-size variation showed a coarsening trend, which agreed with that obtained during in situ measurements in a former study. The changes in Yellow River discharge and precipitation associated with the coarsening trend were further analyzed. The yielded results showed that the coarsening trend and reduction in tidal flat area might be aggravated with overutilization. More reasonable planning would be necessary in this case.

Knockdown of Two Iodothyronine Deiodinase Genes Inhibits Epinephrine-Induced Larval Metamorphosis of the Hard-Shelled Mussel Mytilus coruscus - Xue Shi; Yu-Qing Wang; Yue-Ming Yang; Yi-Feng Li (Frontiers in Marine Science, 2022)
The metamorphosis process is a critical life-changing event for marine invertebrate planktonic larvae to transform into benthic adults, which is crucial for the shellfish bed’s ecosystem stability and seed production in aquaculture. The mechanism of neuroendocrine regulation in the larval metamorphosis of bivalves remains ambiguous. In the present study, the expression of two deiodinase genes, McDx and McDy , was analyzed by whole-mount in situ hybridization at four larval stages in the hard-shelled mussel Mytilus coruscus . The McDx and McDy localized in visceral tissues, nervous system, mantle, and velum, indicating that two deiodinase genes are essential for larval development in M. coruscus . Knockdown of the McDx and McDy in the pediveliger larvae of M. coruscus using electroporation of siRNA significantly ( p < 0.001) reduced McDx and McDy expression. McDx and McDy knockdown reduced larval metamorphosis in 45% and 49% of the pediveliger larvae induced by epinephrine (EPI). It is hypothesised that the knockdown effects of McDx and McDy repress metamorphic induction rather than larval viability, which does not elicit a lethal effect. The present study corroborates a synergistic action of the adrenergic and thyroid hormones signalling pathway in M. coruscus , and suggests the role of McDx and McDy in larval development and metamorphic transition.

Petrogenesis of Early-Middle Jurassic gabbros in southern Tibet with implications for crustal growth in the southern Lhasa subterrane - Liang Li; Hui Xie; Xinghai Lang; Xuhui Wang; Qing He; Yulin Deng; Fuwei Xie (International Geology Review, 2022)

OsAPL controls the nutrient transport systems in the leaf of rice (Oryza sativa L.) - Zhen Yan; Man-Yu Yang; Biligen-Gaowa Zhao; Guo Li; Qing Chao; Feng Tian; Ge Gao; Bai-Chen Wang (Planta, 2022)

D-aspartic acid protects against gingival fibroblasts inflammation by suppressing pyroptosis - Xuechun Du; Baosheng Li; Qing Cai; Shuwei Qiao; Zixuan Wang; Zhen Li; Yuyang Li; Weiyan Meng (Molecular Biology Reports, 2022)

Novel evolutionary insights into nemacheilid cavefish: evidence from comparative analysis of mitochondrial genomes - Lei Zhou; Shihui Huang; Qing Wang; Zhenhai Li; Zongyang Li; Anyou He; Jiehu Chen; Li Liu; Keshu Zou (Journal of Oceanology and Limnology, 2022)

Ambient air pollutants increase the risk of immunoglobulin E–mediated allergic diseases: a systematic review and meta-analysis - Hua Wang; Xian-Bao Li; Xiu-Jie Chu; Nv-Wei Cao; Hong Wu; Rong-Gui Huang; Bao-Zhu Li; Dong-Qing Ye (Environmental Science and Pollution Research, 2022)

Short-term effect of sulfur dioxide (SO2) change on the risk of tuberculosis outpatient visits in 16 cities of Anhui Province, China: the first multi-city study to explore differences in occupational patients - Xin-Qiang Wang; Jia-Wen Zhao; Kang-Di Zhang; Wen-Jie Yu; Jie Wang; Ying-Qing Li; Xin Cheng; Zhen-Hua Li; Yi-Cheng Mao; Cheng-Yang Hu; Kai Huang; Kun Ding; et al. (Environmental Science and Pollution Research, 2022)

Whole-transcriptome sequencing identifies key mRNAs, miRNAs, lncRNAs, and circRNAs associated with unexplained recurrent pregnancy loss - Yan Wang; Qing Cheng; Zhengyi Xia; Ran Zhou; Yiming Li; Lulu Meng; Qing Xu; Jianxin Tan; Zhengfeng Xu (Cell and Tissue Research, 2022)

Historical biogeography of the gingers and its implications for shifts in tropical rain forest habitats - Jian‐Li Zhao; Xiang‐Qin Yu; W. John Kress; Ya‐Li Wang; Yong‐Mei Xia; Qing‐Jun Li (Journal of Biogeography, 2022)
Aim The relationships between biome shifts and global environmental changes in temperate zone habitats have been extensively explored; yet, the historical dynamics of taxa found in the tropical rain forest (TRF) remain poorly known. This study aims to reconstruct the relationships between tropical rain forest shifts and global environmental changes through the patterns of historical biogeography of a pantropical family of monocots, the Zingiberaceae. Location Global. Taxon Zingiberaceae. Methods We sampled DNA sequences (nrITS, trn K, trn L‐ trn F and psb A‐ trn H) from GenBank for 77% of the genera, including 30% of species, in the Zingiberaceae. Global fossil records of the Zingiberaceae were collected from literatures. Rates of speciation, extinction and diversification were estimated based on phylogenetic data and fossil records through methods implemented in BAMM. Ancestral ranges were estimated using single‐tree BioGeoBEARS and multiple‐trees BioGeoBEARS in RASP. Dispersal rate through time and dispersal rate among regions were calculated in R based on the result of ancestral estimation. Results The common ancestor of the Zingiberaceae likely originated in northern Africa during the mid‐Cretaceous, with later dispersal to the Asian tropics. Indo‐Burma, rather than Malesia, was likely a provenance of the common ancestor of Alpinioideae–Zingiberoideae. Several abrupt shifts of evolutionary rates from the Palaeocene were synchronized with sudden global environmental changes. Main conclusions Integrating phylogenetic patterns with fossil records suggests that the Zingiberaceae dispersed to Asia through drift of the Indian Plate from Africa in the late Palaeocene. Formation of island chains, land corridors and warming temperatures facilitated the emigration of the Zingiberaceae to a broad distribution across the tropics. Moreover, dramatic fluctuations of the speciation rate of Zingiberoideae appear to have been synchronized with global climate fluctuations. In general, the evolutionary history of the Zingiberaceae broadens our understanding of the association between TRF shifts in distribution and past global environmental changes, especially the origin of TRF in Southeast Asia.

Anti-inflammatory and antioxidant activities of chemical constituents from the flower buds of Buddleja officinalis - Fei-Bing Huang; Na Liang; Nusrat Hussain; Xu-Dong Zhou; Muhammad Ismail; Qing-Ling Xie; Huang-He Yu; Yu-Qing Jian; Cai-Yun Peng; Bin Li; Bin Liu; Sheng-Huang Chen; et al. (Natural Product Research, 2022)

Effects of Late Pleistocene Climatic Fluctuations on the Phylogeographic and Demographic History of Japanese Scad (Decapterus maruadsi) - Qing-Hua Wang; Ren-Xie Wu; Zhong-Lu Li; Su-Fang Niu; Yun Zhai; Min Huang; Biao Li (Frontiers in Marine Science, 2022)
The Late Pleistocene-Holocene climate fluctuations have greatly influenced the phylogeographic structure and historical dynamics of many marine organisms in the western Pacific marginal seas. Here, we investigated the impact of Pleistocene glacial-interglacial cycles on the phylogeographic structure and demographic dynamics of Decapterus maruadsi , an economically important fish along the coast of the East China Sea (ECS) and northern South China Sea (NSCS). We obtained 430 concatenated sequences (Cyt b + control region, 1548–1554 bp) of D. maruadsi , including 246 newly sampled from the ECS and 184 previously determined from the NSCS. Genetic structure and phylogenetic analysis demonstrated a lack of significant population structure among 16 populations. Moreover, there was no significant differentiation among populations from Chinese coastal waters and northern Vietnam. Neutrality tests, unimodal mismatch distributions, Bayesian skyline plots, and the star-like haplotype networks all indicated a recent demographic expansion for D. maruadsi population during the Late Pleistocene-Holocene, explaining the low genetic diversity in D. maruadsi along the southeast coast of China. Notably, phylogenetic analyses and net genetic distances based on Cyt b jointly confirmed that 57 Cyt b haplotypes identified as D. maruadsi from the previously defined Sundaland-Rosario-Ranong clade actually represented D. russelli . These results not only reveal the complex effects of Pleistocene-Holocene climate fluctuations on the phylogeographic structure and demographic history of D. maruadsi but also provide useful genetic information for the management of genetic resources.

Research on Ecological Security of Shengjin Lake Wetland (Anhui Province of China) Based on TM Images - Zhili Xu; Bin Dong; Xiang Gao; Ping Wang; Qing Wang; Sheng Li; Haifeng Xu; Yaru Liu; Tong Wang; Chunqiu Ren (Journal of the Indian Society of Remote Sensing, 2022)

Numerical simulation of the Rongcharong paleolandslide river-blocking event: implication for the longevity of the landslide dam - Jianhua Yan; Jianping Chen; Fujun Zhou; Yongchao Li; Yiwei Zhang; Feifan Gu; Yansong Zhang; Yuchao Li; Zhihai Li; Yiding Bao; Qing Wang (Landslides, 2022)

Life cycle assessment of rice bran oil production: a case study in China - Li-Hui Sun; Yu-Ying Wang; Yu-Qing Gong (Environmental Science and Pollution Research, 2022)

Preparation of formate-free PMA@MOF-808 catalysts for deep oxidative desulfurization of model fuels - Cheng Wang; Airong Li; Yuling Ma; Shenglan Qing (Environmental Science and Pollution Research, 2022)

Analysis of the spatial distribution and influencing factors of China national forest villages - Guofang Gong; Zhen Wei; Fengtai Zhang; Yuzhen Li; Youzhi An; Qing Yang; Jianfeng Wu; Lu Wang; Pengzhen Yu (Environmental Monitoring and Assessment, 2022)

Electrical resistivity imaging in Shibaozhai area using magnetotelluric sounding: Enlightenment of hydrocarbon reservoirs on the eastern edge of the Sichuan Basin - Shu-Ming Wang; Qing-Yun Di; Gui-An Zou; Xiao-Lu Su; Cai Qian; Ruo Wang; De-Shan Li (Applied Geophysics, 2022)

Double-phase-shift filtering method for harmonic elimination based on AR2U-Net - Bo-Lin Li; Yan-Chun Wang; Hang Yuan; Xue-Qing Liu (Applied Geophysics, 2022)

Expanding the clinical spectrum of adult-onset neuronal intranuclear inclusion disease - Yuwen Cao; Jingying Wu; Yunhua Yue; Chao Zhang; Shihua Liu; Ping Zhong; Shige Wang; Xiaojun Huang; Weiping Deng; Jing Pan; Lan Zheng; Qing Liu; et al. (Acta Neurologica Belgica, 2022)

Anti-hyperglycaemic effect of labdane diterpenes isolated from the rhizome of Amomum maximum Roxb., an edible plant in Southwest China - Chuan-Li Lu; Li-Ning Wang; Ya-Jun Li; Qing-Fei Fan; Qing-Hua Huang; Jun-Jia Chen (Natural Product Research, 2022)

Comparative Analysis of Pseudo-nitzschia Chloroplast Genomes Revealed Extensive Inverted Region Variation and Pseudo-nitzschia Speciation - Ziyan He; Yang Chen; Yichao Wang; Kuiyan Liu; Qing Xu; Yang Li; Nansheng Chen (Frontiers in Marine Science, 2022)
Pseudo-nitzschia is a species-rich genus where many species can induce harmful algae blooms (HABs) associated with the toxin domoic acid (DA) production. Despite the importance of Pseudo-nitzschia species to coastal environments, their genomic information is rather limited, hindering research on biodiversity and evolutionary analysis. In this study, we report full-length chloroplast genomes (cpDNAs) of nine Pseudo‐nitzschia , among which cpDNAs of eight Pseudo-nitzschia species were reported for the first time. The sizes of these Pseudo-nitzschia cpDNAs, which showed typical quadripartite structures, varied substantially, ranging from 116,546 bp to 158,840 bp in size. Comparative analysis revealed the loss of photosynthesis-related gene psaE in cpDNAs of all Pseudo-nitzschia species except that of P. americana , and the selective loss of rpl36 in P. hainanensis . Phylogenetic analysis showed that all Pseudo-nitzschia strains were grouped into two clades, with clade 1 containing cpDNAs of P. multiseries , P. pungens , P. multistriata , and P. americana , and clade 2 containing cpDNAs of P. hainanensis , P. cuspidata , Pseudo-nitzschia sp. CNS00097, P. delicatissima , and P. micropora . The small size of the P. americana cpDNA was primarily due to its shortened inverted repeat (IR) regions. While psaA and psaB were found in the IR regions of cpDNAs of other eight species, these two genes were found outside of the IR regions of P. americana cpDNA. In contrast, P. hainanensis had the largest size because of expansion of IR regions with each IR region containing 15 protein-coding genes (PCGs). Eleven genetic regions of these Pseudo-nitzschia cpDNAs exhibited high nucleotide diversity (Pi) values, suggesting that these regions may be used as molecular markers for distinguishing different Pseudo-nitzschia species with high resolution and high specificity. Phylogenetic analysis of the divergence of nine Pseudo-nitzschia species indicated that these species appeared at approximately 41 Mya. This study provides critical cpDNA resources for future research on the biodiversity and speciation of Pseudo-nitzschia species.

A new highly oxygenated germacranolide from Carpesium nepalense var. lanatum (C.B.Clarke) Kitam - Yi-Fan Yu; Yue-Qian Li; Ru-Yue Wang; Xu Liu; Wen-Bo Cui; Xiao-Han Chen; Cheng-Mu Zhao; Feng-Ming Qi; Zhan-Xin Zhang; Dong-Qing Fei (Natural Product Research, 2022)

Secoiridoid glycosides from the fruits of Cornus officinalis - Xin Wang; Xiang-Jian Zhong; Na Zhou; Lin-Lin Ji; Jin-Jie Li; Ning Cai; Qing-Bo Wang; Peng-Cheng Lin; Xiao-Ya Shang (Natural Product Research, 2022)

PdeHCA2 affects biomass in Populus by regulating plant architecture, the transition from primary to secondary growth, and photosynthesis - Biligen-Gaowa Zhao; Guo Li; Yue-Feng Wang; Zhen Yan; Feng-Qin Dong; Ying-Chang Mei; Wei Zeng; Meng-Zhu Lu; Hong-Bin Li; Qing Chao; Bai-Chen Wang (Planta, 2022)

Mutation of Beclin1 acetylation site at K414 alleviates high glucose-induced podocyte impairment in the early stage of diabetic nephropathy by inhibiting hyperactivated autophagy - Jun Xu; Yujie Deng; Yingying Ke; Yunxia Zhu; Ping Wang; Qing Yu; Chengqian Li; Bimin Shi (Molecular Biology Reports, 2022)

Hyperlipidemia patients carrying LDLR splicing mutation c.1187-2A>G respond favorably to rosuvastatin and PCSK9 inhibitor evolocumab - Xiaoyu Zhang; Qianqian Liu; Hongfu Zhang; Chengcheng Tan; Qiangfeng Zhu; Saiyong Chen; Yinglong Du; Haitao Yang; Qingli Li; Chengqi Xu; Chun Wu; Qing K. Wang (Molecular Genetics and Genomics, 2022)

MiR-1260b protects against LPS-induced degenerative changes in nucleus pulposus cells through targeting TCF7L2 - Shijie Chen; Guixia Shi; Jin Zeng; Ping Huang Li; Yi Peng; Zhiyu Ding; Hong Qing Cao; Ruping Zheng; Weiguo Wang (Human Cell, 2022)

Responses of photosynthesis, antioxidant enzymes, and related gene expression to nicosulfuron stress in sweet maize (Zea mays L.) - Zhen-Xing Wu; Ning-Wei Xu; Min Yang; Xiang-Ling Li; Jin-Ling Han; Xiao-Hu Lin; Qing Yang; Gui-Hua Lv; Jian Wang (Environmental Science and Pollution Research, 2022)

Geochronology and geochemistry of Late Triassic intrusions in the Liaodong Peninsula, eastern North China Craton: implications for post-collisional lithospheric thinning - Chen Wang; Zheng-Hong Liu; Gang Li; Xiao-Jie Dong; Shi-Chao Li; Qing-Ying Zhao (International Geology Review, 2022)

DSRD: deep sparse representation with learnable dictionary for remotely sensed image denoising - Zhenghua Huang; Zhicheng Wang; Qian Li; Junbo Chen; Yaozong Zhang; Hao Fang; Qing An (International Journal of Remote Sensing, 2022)

A Novel Mutation in COL4A1 Gene in a Chinese Family with Pontine Autosomal Dominant Microangiopathy and Leukoencephalopathy - Qing Li; Chengfeng Wang; Wei Li; Zaiqiang Zhang; Shanshan Wang; Autongsha Wupuer; Xiao Hu; Kalibinuer Wumaier; Yi Zhu; Hongyan Li; Wengui Yu (Translational Stroke Research, 2022)
Pontine autosomal dominant microangiopathy and leukoencephalopathy (PADMAL) is a rare hereditary cerebral small vessel disease. We report a novel collagen type IV alpha 1 ( COL4A1 ) gene mutation in a Chinese family with PADMAL. The index case was followed up for 6 years. Neuroimaging, whole-exome sequencing, skin biopsy, and pedigree analysis were performed. She initially presented with minor head injury at age 38. MRI brain showed chronic lacunar infarcts in the pons, left thalamus, and right centrum semiovale. Extensive workup was unremarkable except for a patent foramen ovale (PFO). Despite anticoagulation, PFO closure, and antiplatelet therapy, the patient had recurrent lacunar infarcts in the pons and deep white matter, as well as subcortical microhemorrhages. Whole-exome sequencing demonstrated a novel c.*34G > T mutation in the 3′ untranslated region of COL4A1 gene. Skin biopsy subsequently demonstrated thickening of vascular basement membrane, proliferation of endothelial cells, and stenosis of vascular lumen. Three additional family members had gene testing and 2 of them were found to have the same heterozygous mutation. Of the 18 individuals in the pedigree of 3 generations, 12 had clinical and MRI evidence of PADMAL. The mechanisms of both ischemic and hemorrhagic stroke are likely the overexpression of COLT4A1 in the basement membrane and frugality of the vessel walls. Our findings suggest that the novel c.*34G > T mutation appears to have the same functional consequences as the previously reported COL4A1 gene mutations in patients with PADMAL and multi-infarct dementia of Swedish type.

Survey of Road Extraction Methods in Remote Sensing Images Based on Deep Learning - Pengfei Liu; Qing Wang; Gaochao Yang; Lu Li; Huan Zhang (PFG – Journal of Photogrammetry, Remote Sensing and Geoinformation Science, 2022)

The complete chloroplast genome sequence of Clerodendranthus spicatus, a medicinal plant for preventing and treating kidney diseases from Lamiaceae family - Qing Du; Mei Jiang; Sihui Sun; Liqiang Wang; Shengyu Liu; Chuanbei Jiang; Haidong Gao; Haimei Chen; Yong Li; Bin Wang; Chang Liu (Molecular Biology Reports, 2022)

Cassiterite oxygen isotopes in magmatic-hydrothermal systems: in situ microanalysis, fractionation factor, and applications - Yang Li; Sheng He; Rong-Qing Zhang; Xian-Wu Bi; Lian-Jun Feng; Guo-Qiang Tang; Wen-Zhong Wang; Fang Huang; Xian-Hua Li (Mineralium Deposita, 2022)

Paeoniflorin ameliorates cognitive impairment in Parkinson’s disease via JNK/p53 signaling - Zhu-qing He; Peng-fei Huan; Li Wang; Jian-cheng He (Metabolic Brain Disease, 2022)
Paeoniflorin (PF) has numerous benefits, including anti-inflammatory and anti-apoptosis effects. However, it is not clear if it has neuroprotective effects against cognitive impairment (CI) in Parkinson’s disease (PD). Through network pharmacology, we identified probable targets as well as signal pathways through which PF might affect CI in PD. Then, we experimentally validated our findings. The core genes of the protein-protein interactions (PPI) network include MAPK8 (JNK), TP53, CASP3 (caspase-3), postsynaptic density protein-95 (PSD-95) and synaptophysin (SYN). Pathway enrichment analysis revealed that genes involved in apoptosis and mitogen-activated protein kinase (MAPK) signaling were significantly enriched. Because JNK is a key mediator of p53-induced apoptosis, we wondered if JNK/p53 pathway influences the effects of PF against apoptosis in mouse model of PD. Molecular docking analysis showed that PF had good affinity for JNK/p53. The results of the experiments indicated that PF ameliorated behavioral impairments and upregulated the expression of the dopamine (DA) neurons, suppressed cell apoptosis in substantia nigra pars compacta (SNpc) of PD. Additionally, PF improved 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neuronal injury by inhibiting apoptosis in hippocampal neurons of the CA1 and CA3, and upregulating PSD-95 as well as SYN protein levels. Similar protective effects were observed upon JNK/p53 pathway inhibition using SP600125. Overall, PF improved CI in PD by inhibiting JNK/p53 pathway.

Liposome-Encapsulated Rec8 and Dmrt1 Plasmids Induce Red-Spotted Grouper (Epinephelus akaara) Testis Maturation - Xuzhuo Duan; Xianze Jia; Kaishan Liang; Fengqi Huang; Jinhong Shan; Huitao Chen; Xinhe Ruan; Lihua Li; Huihong Zhao; Qing Wang (Marine Biotechnology, 2022)

Comparative metabolomics provides novel insights into the basis of petiole color differences in celery (Apium graveolens L.) - Mengyao Li; Jie Li; Haohan Tan; Ya Luo; Yong Zhang; Qing Chen; Yan Wang; Yuanxiu Lin; Yunting Zhang; Xiaorong Wang; Haoru Tang (Journal of Zhejiang University-SCIENCE B, 2022)

Combined numerical investigation of the Gangda paleolandslide runout and associated dam breach flood propagation in the upper Jinsha River, SE Tibetan Plateau - Yansong Zhang; Jianping Chen; Fujun Zhou; Yiding Bao; Jianhua Yan; Yiwei Zhang; Yongchao Li; Feifan Gu; Qing Wang (Landslides, 2022)

Short-term effect of ambient air pollutant change on the risk of tuberculosis outpatient visits: a time-series study in Fuyang, China - Xin-Qiang Wang; Ying-Qing Li; Cheng-Yang Hu; Kai Huang; Kun Ding; Xiao-Jing Yang; Xin Cheng; Kang-Di Zhang; Wen-Jie Yu; Jie Wang; Yong-Zhong Zhang; Zhen-tao Ding; et al. (Environmental Science and Pollution Research, 2022)

Dynamics of nitrogen and phosphorus profile and its driving forces in a subtropical deep reservoir - Cunli Li; Ping Zhang; Guangwei Zhu; Chao Chen; Yucheng Wang; Mengyuan Zhu; Hai Xu; Cuiling Jiang; Wei Zou; Pengcheng Shi; Qing Zheng (Environmental Science and Pollution Research, 2022)

Characteristics of circRNAs expression profiles in the piglets intestine induced by oxidative stress - Zhi-xin Li; Wei Chen; Ming Qin; Li-xue Wang; Yong-qing Zeng (Genes & Genomics, 2022)

Four new resorcinol derivatives with neuroprotective activities from Xylaria nigripes - Lan-Qing Li; Jing Li; Hong-Ping Long; Ji-Kai Liu; Xian Wang (Natural Product Research, 2022)

Structure, antioxidant property and protection on PC12 of a polysaccharide isolated and screened from Abelmoschus esculentus L.Moench (okra) - Li-Chao Pan; Yang-Yang Sun; Xiao-Ling Zhang; Zhen-Yuan Zhu; Chun-Yu Liu; Hui-Qing Sun; Xue-Qing Geng; Wei Jiang; Jia-He Wang (Natural Product Research, 2022)

Zinc finger and BTB domain-containing protein 20 aggravates angiotensin II-induced cardiac remodeling via the EGFR-AKT pathway - Fangfang Li; Miaomiao Du; Yiming Yang; Zhu Wang; Hu Zhang; Xiaoyu Wang; Qing Li (Journal of Molecular Medicine, 2022)

Identification of epigenetic modifications mediating the antagonistic effect of selenium against cadmium-induced breast carcinogenesis - Zhuo-Zhi Liang; Yi-Xin Zhang; Rui-Mei Zhu; Yue-Lin Li; Hong-Mei Jiang; Ruo-Bi Li; Qian-Xin Chen; Qing Wang; Lu-Ying Tang; Ze-Fang Ren (Environmental Science and Pollution Research, 2022)

Can artificial light promote submerged macrophyte growth in summer? - Chao Xu; Hai-Jun Wang; Yan Li; Chi Xu; Qing Yu; Miao Liu; Miao Zhang; Hong-Zhu Wang; David P. Hamilton; Erik Jeppesen (Aquatic Ecology, 2022)

Increased abscisic acid sensitivity and drought tolerance of Arabidopsis by overexpression of poplar abscisic acid receptors - Qing Li; Qianqian Tian; Yue Zhang; Mengxue Niu; Xiaoqian Yu; Conglong Lian; Chao Liu; Hou-Ling Wang; Weilun Yin; Xinli Xia (Plant Cell, Tissue and Organ Culture (PCTOC), 2022)

Overexpression of ORX or MCH Protects Neurological Function Against Ischemic Stroke - Gang Wu; Xi’an Zhang; Shijun Li; Dan Zhou; Jie Bai; Hanxiang Wang; Qing Shu (Neurotoxicity Research, 2022)

Cellular metabolic basis of altered immunity in the lungs of patients with COVID-19 - Shuangyan Li; Fuxiaonan Zhao; Jing Ye; Kuan Li; Qi Wang; Zhongchao Du; Qing Yue; Sisi Wang; Qi Wu; Huaiyong Chen (Medical Microbiology and Immunology, 2022)

Aberrant functional and effective connectivity of the frontostriatal network in unilateral acute tinnitus patients with hearing loss - Gang-Ping Zhou; Yu-Chen Chen; Wang-Wei Li; Heng-Le Wei; Yu-Sheng Yu; Qing-Qing Zhou; Xindao Yin; Yue-Jin Tao; Hong Zhang (Brain Imaging and Behavior, 2022)

Delayed body development with reduced triglycerides levels in leptin transgenic pigs - Yubo Qing; Muhammad Ameen Jamal; Dejia Shi; Sumei Zhao; Kaixiang Xu; Deling Jiao; Heng Zhao; Honghui Li; Baoyu Jia; Haizhen Wang; Hong-Ye Zhao; Hong-Jiang Wei (Transgenic Research, 2022)

Evaluation of suitable qRT-PCR normalization genes for various citrus rootstocks - Wen He; Rui Xie; Huan Li; Yan Wang; Qing Chen; Yuanxiu Lin; Yunting Zhang; Ya Luo; Yong Zhang; Haoru Tang; Xiaorong Wang (Plant Biotechnology Reports, 2022)

Infectivity and antigenicity of pseudoviruses with high-frequency mutations of SARS-CoV-2 identified in Portugal - Hai-xin Wang; Li Zhang; Zi-teng Liang; Jian-hui Nie; Jia-jing Wu; Qian-qian Li; Ru-xia Ding; Yue Zhang; Guo-qing Chen; You-chun Wang; Hui-guo Wang; Wei-jin Huang (Archives of Virology, 2022)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had a major impact on global human health. During the spread of SARS-CoV-2, weakened host immunity and the use of vaccines with low efficacy may result in the development of more-virulent strains or strains with resistance to existing vaccines and antibodies. The prevalence of SARS-CoV-2 mutant strains differs between regions, and this variation may have an impact on the effectiveness of vaccines. In this study, an epidemiological investigation of SARS-CoV-2 in Portugal was performed, and the VSV-ΔG-G* pseudovirus system was used to construct 12 spike protein epidemic mutants, D614G, A222V+D614G, B.1.1.7, S477N+D614G, P1162R+D614G+A222V, D839Y+D614G, L176F+D614G, B.1.1.7+L216F, B.1.1.7+M740V, B.1.258, B.1.258+L1063F, and B.1.258+N751Y. The mutant pseudoviruses were used to infect four susceptible cell lines (Huh7, hACE2-293T-293T, Vero, and LLC-MK2) and 14 cell lines overexpressing ACE2 from different species. Mutant strains did not show increased infectivity or cross-species transmission. Neutralization activity against these pseudoviruses was evaluated using mouse serum and 11 monoclonal antibodies. The neutralizing activity of immunized mouse serum was not significantly reduced with the mutant strains, but the mutant strains from Portugal could evade nine of the 11 monoclonal antibodies tested. Neutralization resistance was mainly caused by the mutations S477N, N439K, and N501Y in the spike-receptor binding domain. These findings emphasize the importance of SARS-CoV-2 mutation tracking in different regions for epidemic prevention and control.

Oxidation of organoarsenicals and antimonite by a novel flavin monooxygenase widely present in soil bacteria - Jun Zhang; Jian Chen; Yi‐Fei Wu; Zi‐Ping Wang; Ji‐Guo Qiu; Xiao‐Long Li; Feng Cai; Ke‐Qing Xiao; Xiao‐Xu Sun; Barry P. Rosen; Fang‐Jie Zhao (Environmental Microbiology, 2022)
Summary Arsenic can be biomethylated to form a variety of organic arsenicals differing in toxicity and environmental mobility. Trivalent methylarsenite (MAs(III)) produced in the methylation process is more toxic than inorganic arsenite (As(III)). MAs(III) also serves as a primitive antibiotic and, consequently, some environmental microorganisms have evolved mechanisms to detoxify MAs(III). However, the mechanisms of MAs(III) detoxification are not well understood. In this study, we identified an arsenic resistance ( ars ) operon consisting of three genes, arsRVK , that contribute to MAs(III) resistance in Ensifer adhaerens ST2. ArsV is annotated as an NADPH‐dependent flavin monooxygenase with unknown function. Expression of arsV in the arsenic hypersensitive Escherichia coli strain AW3110 Δars conferred resistance to MAs(III) and the ability to oxidize MAs(III) to MAs(V). In the presence of NADPH and either FAD or FMN, purified ArsV protein was able to oxidize both MAs(III) to MAs(V) and Sb(III) to Sb(V). Genes with arsV ‐like sequences are widely present in soils and environmental bacteria. Metagenomic analysis of five paddy soils showed the abundance of arsV ‐like sequences of 0.12–0.25 ppm. These results demonstrate that ArsV is a novel enzyme for the detoxification of MAs(III) and Sb(III) and the genes encoding ArsV are widely present in soil bacteria.

Passive Sonar Target Tracking Based on Deep Learning - Ying Wang; Hongjian Wang; Qing Li; Yao Xiao; Xicheng Ban (Journal of Marine Science and Engineering, 2022)
At present, the tracking accuracy of underwater passive target tracking is often limited due to models that are overly simple, with low complexity, poor universality, and an inability to learn. In this paper, a cubature Kalman filter (CKF) algorithm based on a gated recurrent unit (GRU) network is proposed. The filter innovation, prediction error, and filter gain obtained from the CKF are used as the input to the GRU network, and the filter error value is used as the output to train the network. End-to-end online learning is carried out using the designed fully connected network, and the current state of the target is predicted. In this paper, a deep neural network based on the GRU architecture is used to convert the tracking prediction problem into a time series prediction problem in the field of artificial intelligence, and its strong fitting ability is used to resolve the uncertainty of the target motion. Simulation results show that an unmanned underwater vehicle (UUV) state estimation method based on the GRU filter proposed in this paper offers better accuracy and stability than the traditional state estimation method.

Best Practice Data Standards for Discrete Chemical Oceanographic Observations - Li-Qing Jiang; Denis Pierrot; Rik Wanninkhof; Richard A. Feely; Bronte Tilbrook; Simone Alin; Leticia Barbero; Robert H. Byrne; Brendan R. Carter; Andrew G. Dickson; Jean-Pierre Gattuso; Dana Greeley; et al. (Frontiers in Marine Science, 2022)
Effective data management plays a key role in oceanographic research as cruise-based data, collected from different laboratories and expeditions, are commonly compiled to investigate regional to global oceanographic processes. Here we describe new and updated best practice data standards for discrete chemical oceanographic observations, specifically those dealing with column header abbreviations, quality control flags, missing value indicators, and standardized calculation of certain properties. These data standards have been developed with the goals of improving the current practices of the scientific community and promoting their international usage. These guidelines are intended to standardize data files for data sharing and submission into permanent archives. They will facilitate future quality control and synthesis efforts and lead to better data interpretation. In turn, this will promote research in ocean biogeochemistry, such as studies of carbon cycling and ocean acidification, on regional to global scales. These best practice standards are not mandatory. Agencies, institutes, universities, or research vessels can continue using different data standards if it is important for them to maintain historical consistency. However, it is hoped that they will be adopted as widely as possible to facilitate consistency and to achieve the goals stated above.

Investigation of the risk of valproic acid–induced tremor: clinical, neuroimaging, and genetic factors - Lili Lan; Xu Zhao; Si Jian; Cun Li; Man Wang; Qing Zhou; Shanshan Huang; Suiqiang Zhu; Huicong Kang; Heidi E. Kirsch (Psychopharmacology, 2022)

MAPK5 and MAPK10 overexpression influences strawberry fruit ripening, antioxidant capacity and resistance to Botrytis cinerea - Yunting Zhang; Yu Long; Yiting Liu; Min Yang; Liangxin Wang; Xiaoyang Liu; Yong Zhang; Qing Chen; Mengyao Li; Yuanxiu Lin; Haoru Tang; Ya Luo (Planta, 2022)

Cloning and functional analysis of soluble acid invertase 2 gene (SbSAI-2) in sorghum - Wuyuntanmanda; Fen-Xia Han; Bao-Qing Dun; Ji Zhang; Zhi Wang; Yi Sui; Li Zhu; Gui-Ying Li (Planta, 2022)

Mdivi-1 Modulates Macrophage/Microglial Polarization in Mice with EAE via the Inhibition of the TLR2/4-GSK3β-NF-κB Inflammatory Signaling Axis - Xiaoqin Liu; Xiaojuan Zhang; Xiaojie Niu; Peijun Zhang; Qing Wang; Xiuhua Xue; Guobin Song; Jiezhong Yu; Guoping Xi; Lijuan Song; Yanhua Li; Cungen Ma (Molecular Neurobiology, 2022)

Nitric Oxide Signaling Pathway in Ventral Tegmental Area is Involved in Regulation of 7,8-Dihydroxyflavone on Alcohol Consumption in Rats - Qing Gao; Tao Yang; Xin-Xin Li; Jun-Wei Xiong; Wei Ma; Yan-Min Xu; Yong Liu; Hong-Yan Zhang; Qi-Yu Wang; Hong-Xuan Wang; Ying Peng; Xiao-Feng Zhu; et al. (Molecular Neurobiology, 2022)

Retraction Note to: Revisiting the male genetic landscape of China: a multi-center study of almost 38,000 Y-STR haplotypes - Michael Nothnagel; Guangyao Fan; Fei Guo; Yongfeng He; Yiping Hou; Shengping Hu; Jiang Huang; Xianhua Jiang; Wook Kim; Kicheol Kim; Chengtao Li; Hui Li; et al. (Human Genetics, 2022)

Effects of B-azolemiteacrylic on life-history traits and demographic parameters of two-spotted spider mite, Tetranychus urticae (Acari: Tetranychidae) - Suqin Shang; Yun Chang; Wei-Zhen Li; Wang Chang-Qing; Nie Peng-Cheng (Experimental and Applied Acarology, 2022)
The present study was conducted to evaluate sublethal effects of B-azolemiteacrylic on the two-spotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae). Female adults of T. urticae were exposed to LC 10 and LC 30 of the acaricide, and the effects on treated females and their offspring were evaluated. The results showed that the fecundity of F 0 female adults treated with LC 10 and LC 30 of B-azolemiteacrylic was reduced by 30.9 and 39.2%, respectively. Longevity and oviposition period of the females were significantly reduced as well. The developmental duration of egg and deutonymph stage of the F 1 generation were not significantly different from that of the control. The protonymph stage after LC 30 treatment lasted significantly longer, whereas the larva, deutonymph and female stage were significantly shorter than the control. The oviposition period of the F 1 generation was significantly shortened, the fecundity of each female decreased significantly, and the ratio of female-to-male was reduced too. Moreover, the average generation period of T. urticae after LC 10 and LC 30 treatments was shorter than that of the control, and the net production rate ( R 0 ), intrinsic rate of increase ( r m ) and finite rate of increase ( λ ) were all reduced by 33.3, 7.5 and 1.9% (LC 10 treatment) and by 51.3, 14.8 and 3.6% (LC 30 treatment), respectively. The population doubling time was prolonged by 7.5 and 14.8% after LC 10 and LC 30 treatments, respectively, compared with the control. These results indicate that B-azolemiteacrylic may effectively inhibit the development rate of the F 0 and F 1 populations of T. urticae , which will help design integrated strategies for the comprehensive control of T. urticae and rational use of pesticides in the field.

Deinococcus aestuarii sp. nov. and Deinococcus aquaedulcis sp. nov., two novel resistant bacteria isolated from pearl river estuary - Ling-Zi Yin; Jia-Ling Li; Ze-Tao Liu; Bao-Zhu Fang; Pandeng Wang; Xiao-Qing Luo; Lei Dong; Li Duan; Shan-Hui Li; Wen-Jun Li (Antonie van Leeuwenhoek, 2022)

Intra-Articular Injection of miR-29a-3p of BMSCs Promotes Cartilage Self-Repairing and Alleviates Pain in the Rat Osteoarthritis - Qing Wang; Yong Chen; Xiaofeng Shen; Ji Chen; Yuwei Li (Tissue Engineering and Regenerative Medicine, 2021)

Mechanical Properties of Limestone After High-Temperature Treatment Under Triaxial Cyclic Loading and Unloading Conditions - Qing-bin Meng; Jiang-Feng Liu; Hai Pu; Li-yuan Yu; Jiang-yu Wu; Cong-kai Wang (Rock Mechanics and Rock Engineering, 2021)

Recombinant Avian β-Defensin Produced by Food-Grade Lactococcus as a Novel and Potent Immunological Enhancer Adjuvant for Avian Vaccine - Tingting Wang; Zhihao Wang; Jielan Mi; Wenqian Wang; Kai Li; Xiaole Qi; Yulong Gao; Li Gao; Changjun Liu; Yanping Zhang; Qing Pan; Xiaomei Wang; et al. (Probiotics and Antimicrobial Proteins, 2021)
In this study, we expressed rAvBD1-2–6-13 protein through Lactococcus lactis NZ3900, and the effects of the recombinant L. lactis NZ3900 as an immune enhancer and immune adjuvant were verified using in vivo and in vitro tests. In vitro tests revealed that recombinant L. lactis NZ3900 significantly activated the NF-κB signaling pathway and IRF signaling pathway in J774-Dual™ report cells and significantly increased the transcript levels of IL-10, IL-12p70, CD80, and CD86 in chicken PBMCs and chicken HD11 cells. In vivo experiments revealed that the immunized group supplemented with recombinant L. lactis NZ3900 as an adjuvant had significantly higher serum antibody titers and higher proliferative activity of PBMCs in the blood of the chickens immunized with NDV live and inactivated vaccines. Our study shows that the recombinant L. lactis NZ3900 has strong immunomodulatory activity both in vivo and in vitro and is a potential immune enhancer. Our work lays the foundation for the research and development of new animal immune enhancers for application in the poultry industry.

Involvement of the nociceptin opioid peptide receptor in morphine-induced antinociception, tolerance and physical dependence in female mice - Xiao-Qing Hao; Zhi-Yuan Wang; Jian-Min Chen; Ning Wu; Jin Li (Metabolic Brain Disease, 2021)

Colorado geoid computation experiment: overview and summary - Yan Ming Wang; Laura Sánchez; Jonas Ågren; Jianliang Huang; René Forsberg; Hussein A. Abd-Elmotaal; Kevin Ahlgren; Riccardo Barzaghi; Tomislav Bašić; Daniela Carrion; Sten Claessens; Bihter Erol; et al. (Journal of Geodesy, 2021)

Spatio-temporal evolution and influencing factors of land use in Tibetan region: 1995–2025 - Li chen; Qing wang (Earth Science Informatics, 2021)

Analysis of the starch properties in tetraploid wheat–Aegilops sharonensis amphidiploid - Qing Li; Xuteng Zhang; Na Lin; Guzmán Carlos; Jingyu Lan; Huaping Tang; Pengfei Qi; Jian Ma; Jirui Wang; Guoyue Chen; Wei Li; Zhien Pu; et al. (Cereal Research Communications, 2021)

Effects of specimen preparation method and strain rate on the mechanical responses of a clayey loess - Dian-Qing Li; Jinyuan Wang; Rui Rui (Arabian Journal of Geosciences, 2021)

A novel BRET based genetic coded biosensor for apoptosis detection at deep tissue level in live animal - Yueling Zhang; Juan Hu; Meijuan Yu; Zhirong Wang; Hucheng Qing; Huheng Fu; Liudi Yuan; Fei Li; Sheng Zhao (Apoptosis, 2021)

Environmental contamination with SARS‐CoV ‐2 in COVID ‐19 hospitals in Wuhan, China, 2020 - Wei Liu; Dingchen Li; Chaojie Yang; Fangyan Chen; Ruizhong Jia; Leili Jia; Xinyi Xia; Shanhong Fan; Qing Tan; Yuehua Ke; Yong Chen; Haifeng Li; et al. (Environmental Microbiology, 2021)
Summary Coronavirus disease 2019 (COVID‐19) pandemic has caused high number of infections and deaths of healthcare workers globally. Distribution and possible transmission route of SARS‐CoV‐2 in hospital environment should be clarified. We herein collected 431 environmental (391 surface and 40 air) samples in the intensive care unit (ICU) and general wards (GWs) of three hospitals in Wuhan, China from February 21 to March 4, 2020, and detected SARS‐CoV‐2 RNA by real‐time quantitative PCR. The viral positive rate in the contaminated areas was 17.8% (28/157), whereas there was no virus detected in the clean areas. Higher positive rate (22/59, 37.3%) was found in ICU than that in GWs (3/63, 4.8%). The surfaces of computer keyboards and mouse in the ICU were the most contaminated (8/10, 80.0%), followed by the ground (6/9, 66.7%) and outer glove (2/5, 40.0%). From 17 air samples in the contaminated areas, only one sample collected at a distance of around 30 cm from the patient was positive. Enhanced surface disinfection and hand hygiene effectively decontaminated the virus from the environment. This finding might help understand the transmission route and contamination risk of SARS‐CoV‐2 and evaluate the effectiveness of infection prevention and control measures in healthcare facilities.

MicroRNA-31-3p/RhoA signaling in the dorsal hippocampus modulates methamphetamine-induced conditioned place preference in mice - Hongyan Qian; Qing Shang; Min Liang; Baoyao Gao; Jing Xiao; Jing Wang; Axiang Li; Canyu Yang; Jianmin Yin; Gang Chen; Tao Li; Xinshe Liu (Psychopharmacology, 2021)

The Utility of Gordon’s Standard NIR Empirical Atmospheric Correction Algorithm for Unmanned Aerial Vehicle Imagery - Liang Ma; Yan Liu; Xiang Yu; Chao Zhan; Bowen Zhang; Lingxing Lu; Zihui Liu; Bing Li; Guangshun Sun; Qing Wang (Journal of the Indian Society of Remote Sensing, 2021)

MamZ protein plays an essential role in magnetosome maturation process of Magnetospirillum gryphiswaldense MSR-1 - Sha Wu; Qing Wang; Xu Wang; Ruixue Guo; Tongwei Zhang; Yongxin Pan; Feng Li; Ying Li (Journal of Oceanology and Limnology, 2021)

Association between ambient air pollution and multiple sclerosis: a systemic review and meta-analysis - Chao Tang; Qing-Ru Li; Yan-Mei Mao; Yuan-Rui Xia; Heng-Sheng Guo; Jun-Ping Wang; Zong-Wen Shuai; Dong-Qing Ye (Environmental Science and Pollution Research, 2021)

Comparison of the Bulk and Rhizosphere Soil Prokaryotic Communities Between Wild and Reintroduced Manglietiastrum sinicum Plants, a Threatened Species with Extremely Small Populations - Dai-Fa Su; Qing-Qing Shen; Jun-Yu Yang; Zhi-Ying Li; Wei Xiao; Yong-Xia Wang; Zhang-Gui Ding; Xiao-Long Cui (Current Microbiology, 2021)

Geochemistry of the Lower Cretaceous limestones in the Eastern Tethys Gyabula Formation (Himalaya, southern Tibet): implications for the depositional environment and tectonic setting - Qing Li; Feng Ding; Micha Ruhl; Yongdong Wang; Ying Li; Lei Yang; Kunzhi Xu; Xiangang Xie (Arabian Journal of Geosciences, 2021)

Sediment Coarsening in Tidal Flats and Stable Coastline of the Abandoned Southern Yellow River Sub-Delta in Response to Fluvial Sediment Flux Decrease During the Past Decades - Lin Zeng; Chao Zhan; Qing Wang; Xianbin Liu; Longsheng Wang; Xueyan Li; Xin Wang; Xiang Yu; Jinzhi Zhang; Buli Cui (Frontiers in Marine Science, 2021)
Due to remarkable reduction of sediment supply, the vulnerability of Yellow River deltaic system increased and ecological impacts occurred to some extent. To have a comprehensive and quantitative understanding of the morphological evolution of deltas, surficial sediments of tidal flat along the abandoned southern Yellow River sub-delta and two adjacent coastal units were systematically collected and evaluated by grain-size analysis in the study. The results reveal that surficial sediments of the abandoned southern Yellow River sub-delta have been coarsening significantly since the 1980s, as characterized by a decrease in both the mud content and the clay/mud ratio. In particular, the transition from cohesive to non-cohesive sediment was completed between 2007 and 2013. With a sharp decrease in sediment flux from the Yellow River estuary, the flood currents from the submarine coastal slope carry few fine particles into the tidal zone, whereas the ebb currents with reverse direction remove some fine particles from the tidal flat. This is a major cause of sediment coarsening in the tidal flat. As sediment coarsening, the coastline of the abandoned southern Yellow River sub-delta has remained stable. The significant change in the grain size of the tidal flat surficial sediments may have a profound impact on the future coastal geomorphic evolution.

The change of hydrological variables and its effects on vegetation in Central Asia - Qing Peng; Ranghui Wang; Yelin Jiang; Cheng Li; Wenhui Guo (Theoretical and Applied Climatology, 2021)
Water is an important factor that affects local ecological environments, especially in drylands. The hydrological cycle and vegetation dynamics in Central Asia (CA) have been severely affected by climate change. In this study, we employed data from Gravity Recovery and Climate Experiment (GRACE), Global Land Data Assimilation System (GLDAS), Global Land Evaporation Amsterdam Model, and Climate Research Unit to analyze the spatiotemporal changes in hydrological factors (terrestrial water storage (TWS), evapotranspiration, precipitation, and groundwater) in CA from 2003 to 2015. Additionally, the spatiotemporal changes in vegetation dynamics and the influence of hydrological variables on vegetation were analyzed. The results showed that the declining rates of precipitation, evapotranspiration, GRACE-TWS change, GLDAS-TWS change and GW change were 0.40 mm/year, 0.11 mm/year, 50.46 mm/year ( p < 0.05), 8.38 mm/year, and 41.18 mm/year ( p < 0.05), respectively. Human activity (e.g., groundwater pumping) was the dominant in determining the GW decline in CA. Precipitation dominated the changes in evapotranspiration, GRACE-TWS and GLDAS-TWS ( p < 0.05). The 2- to 3-month lagging signal has to do with the transportation from the ground surface to groundwater. The change in the normalized difference vegetation index (NDVI) from 2003 to 2015 indicated the slight vegetation degradation in CA. The results highlighted that precipitation, terrestrial water storage, and soil moisture make important contributions to the vegetation dynamics changes in CA. The effect of precipitation on vegetation growth in spring was significant ( p < 0.05), while the soil moisture effect on vegetation in summer and autumn was higher than that of precipitation.

Expanding the scope of genome editing with SpG and SpRY variants in rice - Jun Ren; Xiangbing Meng; Fengyue Hu; Qing Liu; Yuexuan Cao; Huiying Li; Changjie Yan; Jiayang Li; Kejian Wang; Hong Yu; Chun Wang (Science China Life Sciences, 2021)

Genome-wide analysis and characterization of R2R3-MYB family in pigeon pea (Cajanus cajan) and their functional identification in phenylpropanoids biosynthesis - Jie Yang; Su Zhang; Hongquan Li; Litao Wang; Ying Liu; Lili Niu; Qing Yang; Dong Meng; Yujie Fu (Planta, 2021)

Responses of leaf litter decomposability to nitrogen and phosphorus additions are associated with cell wall carbohydrate composition in a subtropical plantation - Xiang-Min Fang; Xiu-Lan Zhang; Ying-Ying Zong; Wen-Qing Li; Jian-Jun Li; Li-Ping Guo; Huimin Wang; Fu-Sheng Chen (Plant and Soil, 2021)

Combination of Electroacupuncture and Constraint-Induced Movement Therapy Enhances Functional Recovery After Ischemic Stroke in Rats - Dong Wang; Lijuan Li; Qing Zhang; Zejun Liang; Liyi Huang; Chengqi He; Quan Wei (Journal of Molecular Neuroscience, 2021)

Diversity and arsenic-metabolizing gene clusters of indigenous arsenate-reducing bacteria in high arsenic groundwater of the Hetao Plain, Inner Mongolia - Yanhong Wang; Dazhun Wei; Ping Li; Zhou Jiang; Han Liu; Chun Qing; Helin Wang (Ecotoxicology, 2021)

Inhibition of Maternal c-Src Ameliorates the Male Offspring Hypertension by Suppressing Inflammation and Neurotransmitters in the Paraventricular Nucleus - Qing Su; Xiao-Jing Yu; Qing Yang; Xiao-Min Wang; Wen-Jie Xia; Hong-Bao Li; Kai-Li Liu; Qiu-Yue Yi; Yu-Ming Kang (Cardiovascular Toxicology, 2021)

Pollution Characteristics of Microplastics in Mollusks from the Coastal Area of Yantai, China - Jiajia Liu; Xiaopeng Zhu; Jia Teng; Jianmin Zhao; Chenghua Li; Encui Shan; Chen Zhang; Qing Wang (Bulletin of Environmental Contamination and Toxicology, 2021)

Resting-state abnormalities in functional connectivity of the default mode network in autism spectrum disorder: a meta-analysis - Qing Wang; Hua-Yun Li; Yun-Da Li; Ya-Ting Lv; Hui-Bin Ma; An-Feng Xiang; Xi-Ze Jia; Dong-Qiang Liu (Brain Imaging and Behavior, 2021)

Deep profile soil moisture distribution characteristics for different micro-topographies on the semi-arid Loess Plateau, China - Qing-ping Gou; Qing-ke Zhu; Yi-xuan Li; Xiang-lei Tian; Peng-xiang Wang; Yun-ling Xin; Shu-yuan Luo (Journal of Mountain Science, 2021)

Effects of Dietary Protein and Lipid Levels on Growth Performance, Muscle Composition, Immunity Index and Biochemical Index of the Greenfin Horse-Faced Filefish (Thamnaconus septentrionalis) Juvenile - Zhengxin Xu; Pengfei Zhang; Qing Chang; Siqing Chen; Li Bian; Zhida Wang (Journal of Ocean University of China, 2021)

Highly sialylated mucin-type glycopeptide from porcine intestinal mucosa after heparin extraction: O-glycan profiling and immunological activity evaluation - Xin Zhang; Chen Wang; Qing Han; Xuan Chen; Guoyun Li; Guangli Yu (Glycoconjugate Journal, 2021)

A new indole alkaloid with HUVEC proliferation activities from Nauclea officinalis - Shi-Ying Mai; Yong-Hui Li; Xu-Guang Zhang; Yi-Ran Wang; Jun-Qing Zhang; An Jia (Natural Product Research, 2021)

MS1 is essential for male fertility by regulating the microsporocyte cell plate expansion in soybean - Xiaolong Fang; Xiaoyuan Sun; Xiangdong Yang; Qing Li; Chunjing Lin; Jie Xu; Wenjun Gong; Yifan Wang; Lu Liu; Limei Zhao; Baohui Liu; Jun Qin; et al. (Science China Life Sciences, 2021)

Comparison of pramipexole and levodopa/benserazide combination therapy versus levodopa/benserazide monotherapy in the treatment of Parkinson’s disease: a systematic review and meta-analysis - De-Qi Jiang; Qing-Min Zang; Li-Lin Jiang; Yan Wang; Ming-Xing Li; Jing-Yi Qiao (Naunyn-Schmiedeberg's Archives of Pharmacology, 2021)

The advances of topology optimization techniques in orthopedic implants: A review - Naichao Wu; Shan Li; Boyan Zhang; Chenyu Wang; Bingpeng Chen; Qing Han; Jincheng Wang (Medical & Biological Engineering & Computing, 2021)

A New AR Method Using BDS Triple-Frequency Observation - Gaochao Yang; Qing Wang; Shiyang Zhou; Bo Zhang; Xin Li (Journal of the Indian Society of Remote Sensing, 2021)

Transcriptome sequencing of wild soybean revealed gene expression dynamics under low nitrogen stress - Qi Sun; Haoran Lu; Qing Zhang; Di Wang; Jun Chen; Jialei Xiao; Xiaodong Ding; Qiang Li (Journal of Applied Genetics, 2021)

Clinical characteristics and serotype distribution of invasive pneumococcal disease in pediatric patients from Beijing, China - Yan Xu; Qing Wang; Kaihu Yao; Fang Dong; Wenqi Song; Gang Liu; Baoping Xu; Wei Shi; Yue Li; Kechun Li; Yingchao Liu; Suyun Qian (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Human Methylmercury Exposure and Potential Impacts in Central Tibet: Food and Traditional Tibetan Medicine - Menghan Cheng; Maodian Liu; Dou Li; Qing Luo; Zhihao Zhang; Liuliang Yuan; Chenghao Yu; Han Xie; Huiming Lin; Qianru Zhang; De Ji; Xuejun Wang (Bulletin of Environmental Contamination and Toxicology, 2021)

Root rot-infected Sanqi ginseng rhizosphere harbors dynamically pathogenic microbiotas driven by the shift of phenolic acids - Baoying Wang; Qing Xia; Yunlong Li; Jun Zhao; Shaozhou Yang; Fugang Wei; Xinqi Huang; Jinbo Zhang; Zucong Cai (Plant and Soil, 2021)

Recombinant L-HN Fusion Antigen Derived from the L and HN Domains of Botulinum Neurotoxin B Stimulates a Protective Antibody Response Against Active Neurotoxin - Zhen Li; Jian-Sheng Lu; Shan Liu; Rong Wang; Qing Xu; Yun-Zhou Yu; Zhi-Xin Yang (Neurotoxicity Research, 2021)

The Protective A673T Mutation of Amyloid Precursor Protein (APP) in Alzheimer’s Disease - Qing Xia; XinYu Yang; JiaBin Shi; ZiJie Liu; YaHui Peng; WenJing Wang; BoWen Li; Yu Zhao; JiaYing Xiao; Lei Huang; DaYong Wang; Xu Gao (Molecular Neurobiology, 2021)

Titanium dioxide nanotubes as drug carriers for infection control and osteogenesis of bone implants - Kun Wang; Haoyu Jin; Qing Song; Jingjing Huo; Jing Zhang; Peng Li (Drug Delivery and Translational Research, 2021)

OSL chronology of a Palaeolithic site in a humid subtropical mountainous area of southeast China - Jian-hui Jin; Xiao-yang Wang; Zhen-yu Zhou; Yun-ming Huang; Xue-chun Fan; Xin-xin Zuo; Zhi-zhong Li; Zhi-yong Ling; Yong-qing Ren; Shu-tong Li (Journal of Mountain Science, 2021)

Quartz grain surface microtextural evidence for provenance of the Quaternary aggradation red earth deposit, southern China - Qing-bin Fan; Jie Liao; Li Yan; Wei Ye; Tao Wang; Xiao Feng (Journal of Mountain Science, 2021)

Comparison and Calibration of Elemental Measurements in Sediments Using X-Ray Fluorescence Core Scanning with ICP Methods: A Case Study of the South China Sea Deep Basin - Fangjian Xu; Bangqi Hu; Chen Wang; Jingtao Zhao; Feifei Wang; Xue Ding; Qing Li; Jianwei Guo (Journal of Ocean University of China, 2021)

Dynamical and Machine Learning Hybrid Seasonal Prediction of Summer Rainfall in China - Jialin Wang; Jing Yang; Hong-Li Ren; Jinxiao Li; Qing Bao; Miaoni Gao (Journal of Meteorological Research, 2021)

Trade-offs/Synergies in Land-use Function Changes in Central China from 2000 to 2015 - Qing Li; Yong Zhou; Tao Xu; Li Wang; Qian Zuo; Jingyi Liu; Xueping Su; Nan He; Zhengxiang Wu (Chinese Geographical Science, 2021)

Serological responses to koi herpesvirus (KHV) in a non‐cyprinid reservoir host - Sven Michael Bergmann; Juliane Dabels; Sandro Klafack; Yeonwha Jin; Pei‐Yu Lee; Arndt Christian Hofmann; Yingying Wang; Qing Wang; Yingying Li; Weiwei Zeng; Angela Lusiastuti; Shucheng Zheng; et al. (Journal of Fish Diseases, 2021)
Koi herpesvirus (KHV) is a highly contagious virus that causes KHV disease (KHVD) inducing high mortality in carp and koi ( Cyprinus carpio L.). In the late stage, latency occurs with very low, often non‐detectable virus concentrations, which represents a challenge for virus detection. After validation according to OIE recommendations, an antibody ELISA was established to recognize antibodies of C . carpio against KHV infection. In this study, the ELISA was modified to detect anti‐KHV antibodies from a non‐cyprinid fish. Experimentally infected rainbow trout ( Oncorhynchus mykiss ) were able to transmit KHV to naïve carp at two different temperatures, demonstrating their potential as a reservoir host. At 20°C, KHVD was induced in carp but not at 15°C. Unexpectedly, rainbow trout developed humoral response against KHV at both temperatures. In contrast to carp, at 15°C trout produced neutralizing antibodies but not at 20°C. While antibodies obtained from infected carp sera reacted in a similar way against all KHV, antibodies from rainbow trout sera reacted differently to the same isolates by ELISA. The data show that even when non‐cyprinid fish species are infected with KHV, they can produce antibodies that differ from those observed in carp.

Transcriptome analysis of wolf spider Pardosa laura exposed to beta-cypermethrin - Qing Ning; Jing Li; Li-hua Wang; Yu-jun Dai; Chang-chun Li (International Journal of Tropical Insect Science, 2021)

A new ent -kaurane diterpene from Isodon henryi - Xue Jiang; Ling-Xia Zhang; Qing-Mei Feng; Hong Wu; Ya-Lin Liu; De-Qin Wang; Li-Ping Dai; Zhi-Min Wang (Natural Product Research, 2021)

Short-term waterlogging-induced autophagy in root cells of wheat can inhibit programmed cell death - Li-Lang Zhou; Kai-Yue Gao; Li-Sha Cheng; Yue-Li Wang; Yi-Keng Cheng; Qiu-Tao Xu; Xiang-Yi Deng; Ji-Wei Li; Fang-Zhu Mei; Zhu-Qing Zhou (Protoplasma, 2021)

Numerical study of the seasonal salinity budget of the upper ocean in the Bay of Bengal in 2014 - Qingyue Wang; Changming Dong; Junde Li; Jingsong Yang; Qing Tian (Journal of Oceanology and Limnology, 2021)

Dissociable plasticity of visual-motor system in functional specialization and flexibility in expert table tennis players - Dazhi Yin; Xuefei Wang; Xiaoyou Zhang; Qiurong Yu; Yu Wei; Qing Cai; Mingxia Fan; Lin Li (Brain Structure and Function, 2021)

Development of a double‐antibody sandwich enzyme‐linked immunosorbent assay (DAS‐ELISA) for the detection of KHV - Yingying Li; Qing Wang; Feng Hu; Yingying Wang; Sven M. Bergmann; Weiwei Zeng; Jiyuan Yin; Cunbin Shi (Journal of Fish Diseases, 2021)
Koi herpesvirus disease (KHVD) caused by the koi herpesvirus (KHV) is difficult to diagnose in live fish, presenting a challenge to the koi industry. The enzyme‐linked immunosorbent assay (ELISA) method cannot be widely used to detect KHV because few commercial anti‐KHV antibody exists. Here, we developed an anti‐ORF132 polyclonal antibody and confirmed its reactivity via indirect immunofluorescence assay and Western blotting. A double‐antibody sandwich ELISA (DAS‐ELISA) was established to detect KHV, monoclonal antibody 1B71B4 against ORF92 was used as the capture antibody, and the detection antibody was the polyclonal antibody against the truncated ORF132. The lowest limit was 1.56 ng/ml KHV. Furthermore, the DAS‐ELISA reacted with KHV isolates, while no cross‐reactions occurred with carp oedema virus, spring viraemia of carp virus, frog virus 3 and grass carp reovirus. Two hundred koi serum samples from Guangdong, China, were used in the DAS‐ELISA test, and the positive rate of the koi sera was 13%. The clinical sensitivity and specificity of the DAS‐ELISA relative to the traditional PCR method were 66.7% and 97.6%, respectively. Our findings may be useful for diagnosing and preventing KHVD in koi and common carp.

Neurovascular Units and Neural-Glia Networks in Intracerebral Hemorrhage: from Mechanisms to Translation - Qing Sun; Xiang Xu; Tianyi Wang; Zhongmou Xu; Xiaocheng Lu; Xiang Li; Gang Chen (Translational Stroke Research, 2021)

Genetic Architecture of Childhood Kidney and Urological Diseases in China - Ye Fang; Hua Shi; Tianchao Xiang; Jiaojiao Liu; Jialu Liu; Xiaoshan Tang; Xiaoyan Fang; Jing Chen; Yihui Zhai; Qian Shen; Guomin Li; Li Sun; et al. (Phenomics, 2021)
Kidney disease is manifested in a wide variety of phenotypes, many of which have an important hereditary component. To delineate the genotypic and phenotypic spectrum of pediatric nephropathy, a multicenter registration system is being implemented based on the Chinese Children Genetic Kidney Disease Database (CCGKDD). In this study, all the patients with kidney and urological diseases were recruited from 2014 to 2020. Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features. The genetic diagnosis was confirmed in 883 of 2256 (39.1%) patients from 23 provinces in China. Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome (SRNS, 23.5%), glomerulonephritis (GN, 32.2%), congenital anomalies of the kidney and urinary tract (CAKUT, 21.2%), cystic renal disease (3.9%), renal calcinosis/stone (3.6%), tubulopathy (9.7%), and chronic kidney disease of unknown etiology (CKDu, 5.8%). The pathogenic variants of 105 monogenetic disorders were identified. Ten distinct genomic disorders were identified as pathogenic copy number variants (CNVs) in 11 patients. The diagnostic yield differed by subgroups, and was highest in those with cystic renal disease (66.3%), followed by tubulopathy (58.4%), GN (57.7%), CKDu (43.5%), SRNS (29.2%), renal calcinosis /stone (29.3%) and CAKUT (8.6%). Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions. We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed. Our data demonstrate the utility of family-based exome sequencing, and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease.

Galectin-9 Promotes Neuronal Restoration via Binding TLR-4 in a Rat Intracerebral Hemorrhage Model - Tianyu Liang; Cheng Ma; Tianyi Wang; Ruming Deng; Jiasheng Ding; Wenjie Wang; Zhongmou Xu; Xiang Li; Haiying Li; Qing Sun; Haitao Shen; Zhong Wang; et al. (NeuroMolecular Medicine, 2021)

MiR-146a Negatively Regulates Aspergillus fumigatus-Induced TNF-α and IL-6 Secretion in THP-1 Macrophages - Jianbo Tong; Zhimin Duan; Rong Zeng; Leilei Du; Song Xu; Liwei Wang; Yuzhen Liu; Qing Chen; Xu Chen; Min Li (Mycopathologia, 2021)

Prediction of complications and fusion outcomes of fused lumbar spine with or without fixation system under whole-body vibration - Qing-Dong Wang; Li-Xin Guo (Medical & Biological Engineering & Computing, 2021)

Five matrine-type alkaloids from Sophora tonkinensis - Qing Tang; Ding Luo; Ding-Chai Lin; Wen-Zhi Wang; Can-Jie Li; Xue-Fang Zhuo; Zhong-Nan Wu; Yu-Bo Zhang; Guo-Cai Wang; Yao-Lan Li (Journal of Natural Medicines, 2021)

Brucellosis screening and follow-up of seropositive asymptomatic subjects among household members of shepherds in China - Jing Hu; Xiangyi Zhang; Huixin Yang; Siwen Zhang; Taijun Wang; Shuqi An; Mujinyan Li; Fande Li; Jingjing Luo; Fangfang Hu; Dali Wang; Shaonan Ni; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Correction to: Quantifying soil N2O emissions from soil and anaerobically digested swine manure, nitrification and denitrification using 15N isotope labeling method - Qing Yan; Houhua Yang; Lei Yan; Keqiang Zhang; Jiajia Li; Feng Wang (Environmental Science and Pollution Research, 2021)

Quantifying soil N2O emissions from soil and anaerobically digested swine manure, nitrification and denitrification using 15N isotope labeling method - Qing Yan; Houhua Yang; Lei Yan; Keqiang Zhang; Jiajia Li; Feng Wang (Environmental Science and Pollution Research, 2021)

Altered structural and functional connectivity in CSF1R-related leukoencephalopathy - Fei-Xia Zhan; Ze-Yu Zhu; Qing Liu; Hai-Yan Zhou; Xing-Hua Luan; Xiao-Jun Huang; Xiao-Li Liu; Wo-Tu Tian; Shi-Ge Wang; Xiao-Xuan Song; Guang Chen; Ming-Liang Zhao; et al. (Brain Imaging and Behavior, 2021)

Age of the Silurian Lower Red Beds in South China: Stratigraphical Evidence from the Sanbaiti Section - Zhongyang Chen; Peep Männik; Junxuan Fan; Chengyuan Wang; Qing Chen; Zongyuan Sun; Dongyang Chen; Chao Li (Journal of Earth Science, 2021)

Genome-wide identification of GMP genes in Rosaceae and functional characterization of FaGMP4 in strawberry (Fragaria × ananassa) - Yuanxiu Lin; Jiahao Zhang; Lintai Wu; Yunting Zhang; Qing Chen; Mengyao Li; Yong Zhang; Ya Luo; Yan Wang; Xiaorong Wang; Haoru Tang (Genes & Genomics, 2021)

Isolation and characterization of ent -pimarane diterpenoids from Sigesbeckia pubescens - Jianbin Wang; Kehui Xie; Qing Wang; Wenchao Li; Hongzheng Fu (Natural Product Research, 2021)

Serological evidence of bovine viral diarrhea virus and peste des petits ruminants virus infection in alpacas (Vicugna pacos) in Shanxi Province, northern China - Qing Liu; Lu Liu; Yu-Kai Meng; Chen Wang; Yu Gao; Fu-Guo Zheng; Hai-Li Ma (Tropical Animal Health and Production, 2021)

Construction of the first high-density genetic map for growth related QTL analysis in Ancherythroculter nigrocauda - Yanhong Sun; Pei Li; Guiying Wang; Renli Sun; Jian Chen; Qi Zhou; Jingou Tong; Qing Li (Journal of Oceanology and Limnology, 2021)

The optimal number of embryo cells for effective pregnancy and decrease of multiple pregnancy rate in frozen-thawed embryo transfer - Xu-Li Zhu; Zhi-Ming Zhao; Yuan-Jie Du; Liang Zhou; Yue Wang; Qing-Yun Sun; Gui-Min Hao; Bu-Lang Gao (Human Cell, 2021)

A functional polymorphism of inhibin alpha subunit at miR-181b-1-3p-binding site regulates proliferation and apoptosis of chicken ovarian granular cells - Zhifu Cui; Xiaoxu Shen; Xianxian Zhang; Fugui Li; Felix Kwame Amevor; Qing Zhu; Yan Wang; Diyan Li; Gang Shu; Yaofu Tian; Xiaoling Zhao (Cell and Tissue Research, 2021)

A calculation model of the normal coefficient of restitution based on multi-factor interaction experiments - Zhong-Min Ji; Zhi-Jian Chen; Qing-He Niu; Ting-Hui Wang; Tian-Jun Wang; Tian-Li Chen (Landslides, 2021)

Correction to: Central Blockade of E-Prostanoid 3 Receptor Ameliorated Hypertension Partially by Attenuating Oxidative Stress and Inflammation in the Hypothalamic Paraventricular Nucleus of Spontaneously Hypertensive Rats - Fang-Fang Wang; Juan Bai; Xiao-Jing Yu; Xiao-Lian Shi; Jin-Jun Liu; Kai-Li Liu; Li-Yan Fu; Qing Su; Hong-Bao Li; Kai B. Kang; Qiu-Yue Yi; Shu-Qiu Wang; et al. (Cardiovascular Toxicology, 2021)

Central Blockade of E-Prostanoid 3 Receptor Ameliorated Hypertension Partially by Attenuating Oxidative Stress and Inflammation in the Hypothalamic Paraventricular Nucleus of Spontaneously Hypertensive Rats - Fang-Fang Wang; Juan Ba; Xiao-Jing Yu; Xiao-Lian Shi; Jin-Jun Liu; Kai-Li Liu; Li-Yan Fu; Qing Su; Hong-Bao Li; Kai B. Kang; Qiu-Yue Yi; Shu-Qiu Wang; et al. (Cardiovascular Toxicology, 2021)

Activity evolution of landslides and debris flows after the Wenchuan earthquake in the Qipan catchment, Southwest China - Qing-yun Shi; Chuan Tang; Ling-feng Gong; Ming Chen; Ning Li; Wei Zhou; Jiang Xiong; Hai Tang; Xiao-di Wang; Ming-wei Li (Journal of Mountain Science, 2021)

Complex microbial communities inhabiting natural Cordyceps militaris and the habitat soil and their predicted functions - Xiao-Mei Zhang; De-Xiang Tang; Qing-Qing Li; Yuan-Bing Wang; Zhi-Hong Xu; Wen-Jun Li; Hong Yu (Antonie van Leeuwenhoek, 2021)

Development of an In Vivo Predictive Dissolution Methodology of Topiroxostat Immediate-Release Tablet Using In Silico Simulation - Gang Li; Haiyang Yang; Wei Liu; Chen Shen; Yanhua Ji; Yilu Sun; Qing Huo; Yang Liu; Guopeng Wang (AAPS PharmSciTech, 2021)

Development of a real‐time recombinase polymerase amplification assay for rapid detection of Aeromonas hydrophila - Yang Qu; Qing Wang; Yingying Li; Yingying Wang; Jiyuan Yin; Yan Ren; Chun Liu; Xiaofang Liu; Yahui Wang; Weiwei Zeng (Journal of Fish Diseases, 2021)
Aeromonas hydrophila is ubiquitous in the aquaculture industry and a constant cause of severe disease and economic losses. The early diagnosis of these infections is crucial for disease surveillance and prevention. We developed a real‐time recombinase polymerase amplification (real‐time RPA) assay for detection of A. hydrophila using the haemolysin gene. The assay was performed at 37°C for 20 min and was highly specific with no cross‐reaction with other fish pathogens or with other Aeromonas species. The assay detection limit was 10 2 copies of the Aeromonas hydrophila per reaction. Compared with traditional culture‐based method or real‐time PCR, the diagnostic sensitivity and specificity of the real‐time RPA were 73.7 and 100%, as well as 64.7 and 93%. Our newly developed real‐time RPA was specific and sensitive and can be used in large‐scale and point‐of‐care field investigations of A. hydrophila infections to enable earlier diagnoses.