A cation-anion synergetic additive achieving long-term stability of lithium metal anode - Zhipeng Jiang; Chen Li; Jisheng Mo; Hanxu Yang; Hai-Wen Li; Qingan Zhang; Yongtao Li (Chemical Engineering Journal, 2023)

Slc9a1 plays a vital role in chitosan oligosaccharide transport across the intestinal mucosa of mice - Jiaying Wen; Shengwei Chen; Minglong Bao; Canying Hu; Lianyun Wu; Yanhong Yong; Xiaoxi Liu; Youquan Li; Zhichao Yu; Xingbin Ma; Jong-Bang Eun; Jae-Han Shim; et al. (Carbohydrate Polymers, 2023)

Resistance of QYm.nau-2D to wheat yellow mosaic virus was derived from an alien introgression into common wheat - Yiming Chen; Jialun Ji; Dehui Kong; Xiong Tang; Mingxing Wen; Guoqing Wang; Keli Dai; Peiyao Shi; Xu Zhang; Huajian Zhang; Chengzhi Jiao; Zongkuan Wang; et al. (Theoretical and Applied Genetics, 2023)

Genistein attenuates neuroinflammation and oxidative stress and improves cognitive impairment in a rat model of sepsis-associated encephalopathy: potential role of the Nrf2 signaling pathway - Buyun Shi; Ming Chen; Zhi Xia; Wen Tang; Yong Li; Chenguang Qin; Amir Ahmadi; Chengjiao Huang; Hui Xu (Metabolic Brain Disease, 2023)

Soil water and salt migration in oasis farmland during crop growing season - Dengke Ma; Zhibin He; Lisha Wang; Wenzhi Zhao; Longfei Chen; Pengfei Lin; Peng Zhao; Wen Wang; Yuan Gao; Jing Li (Journal of Soils and Sediments, 2023)

Correction to: Ketone Body Rescued Seizure Behavior of LRP1 Deficiency in Drosophila by Modulating Glutamate Transport - Jin-Ming Zhang; Ming-Jie Chen; Jiong-Hui He; Ya-Ping Li; Zhi-Cai Li; Zi-Jing Ye; Yong-Hui Bao; Bing-Jun Huang; Wen-Jie Zhang; Ping Kwan; Yu-Ling Mao; Jing-da Qiao (Journal of Molecular Neuroscience, 2023)

Andrographolide ameliorates hepatic steatosis by suppressing FATP2-mediated fatty acid uptake in mice with nonalcoholic fatty liver disease - Li-Sha Ran; Ya-Zeng Wu; Yi-Wen Gan; Hong-Lian Wang; Li-Juan Wu; Chun-Mei Zheng; Yao Ming; Ran Xiong; Yong-Lin Li; Shi-Hang Lei; Xue Wang; Xiao-Qing Lao; et al. (Journal of Natural Medicines, 2023)
Excessive intrahepatocellular lipid accumulation or steatosis is caused by abnormal lipid metabolism and a common character of nonalcoholic fatty liver disease (NAFLD), which may progress into cirrhosis and hepatocellular cancer. Andrographolide (Andro) is the primary active ingredient extracted from Andrographis paniculata , showing a protective role against dietary steatosis with the mechanism not fully understood. In this study, we showed that administration of Andro (50, 100, and 200 mg/kg/day for 8 weeks, respectively) attenuated obesity and metabolic syndrome in high-fat diet (HFD)-fed mice with improved glucose tolerance, insulin sensitivity, and reduced hyperinsulinemia, hyperglycemia, and hyperlipidemia. HFD-fed mice presented hepatic steatosis, which was significantly prevented by Andro. In vitro, Andro decreased the intracellular lipid droplets in oleic acid-treated LO2 cells. The selected RT-PCR array revealed a robust expression suppression of the fatty acid transport proteins (FATPs) by Andro treatment. Most importantly, we found that Andro consistently reduced the expression of FATP2 in both the oleic acid-treated LO2 cells and liver tissues of HFD-fed mice. Overexpression of FATP2 abolished the lipid-lowering effect of Andro in oleic acid-treated LO2 cells. Andro treatment also reduced the fatty acid uptake in oleic acid-treated LO2 cells, which was blunted by FATP2 overexpression. Collectively, our findings reveal a novel mechanism underlying the anti-steatosis effect of Andro by suppressing FATP2-mediated fatty acid uptake, suggesting the potential therapeutic application of Andro in the treatment of NAFLD. Graphical abstract

Viperin deficiency promotes dendritic cell activation and function via NF-kappaB activation during Mycobacterium tuberculosis infection - Xinying Zhou; Hui Xu; Qianna Li; Qi Wang; Honglin Liu; Yingqi Huang; Yao Liang; Linmiao Lie; Zhenyu Han; Yaoxin Chen; Yulan Huang; Wenle Zhou; et al. (Inflammation Research, 2023)
Objectives and design Dendritic cells (DCs) are one of the key immune cells in bridging innate and adaptive immune response against Mycobacterium tuberculosis (Mtb) infection. Interferons (IFNs) play important roles in regulating DC activation and function. Virus-inhibitory protein, endoplasmic reticulum-associated, interferon-inducible (Viperin) is one of the important IFN-stimulated genes (ISGs), and elicits host defense against infection. Methods We investigated the effects and mechanisms of Viperin on DC activation and function using Viperin deficient bone marrow-derived dendritic cells (BMDCs) during Mtb infection. Results Viperin deficiency enhanced phagocytic activity and increased clearance of Mtb in DCs, produced higher abundance of NO, cytokine including interleukin-12 (IL-12), Tumor necrosis factor-α (TNF- α ), IL-1 β , IL-6 and chemokine including CXCL1, CXCL2 and CXCL10, elevated MHC I, MHC II and co-stimulatory molecules expression, and enhanced CD4 + and CD8 + T cell responses. Mechanistically, Viperin deficiency promoted DC activation and function through NF-κB p65 activation. NF-κB p65 inhibitor prevented cytokine and chemokine production, and co-stimulatory molecules expression promoted by Viperin deficiency. Conclusions These results suggest that Mtb induced Viperin expression could impair the activation of host defense function of DCs and DC-T cell cross talk during Mtb infection. This research may provide a potential target for future HDT in TB therapy.

Geochemical characteristics of heavy metals of bedrock, soil, and tea in a metamorphic rock area of Guizhou Province, China - Qihang Li; Chaofeng Li; Lanjun Liu; Wang Heng; Cheng Chen; Jie Long; Xuefeng Wen (Environmental Science and Pollution Research, 2023)

Exploration of long afterglow luminescent materials composited with graphitized carbon nitride for photocatalytic degradation of basic fuchsin - Shan-Shan Li; Min Liu; Li Wen; Zhou Xu; Yun-Hui Cheng; Mao-Long Chen (Environmental Science and Pollution Research, 2023)

Effects of Toxin-Antitoxin System HicAB on Biofilm Formation by Extraintestinal Pathogenic E. coli - Bo Hou; Chen-Yan Wang; Shao-Wen Li; Lun-Jiang Zhou; Yong-Liang Che; Qiu-Yong Chen (Current Microbiology, 2023)

Effect of divalent cations on electrochemiluminescence of metal-organic frameworks in bioassay - Xuyu Feng; Bin Li; Longyi Zhu; Wen Chen; Ying Wu; Yanru Duan; Meiyan Song; Ying Wan; Shengyuan Deng (Analytica Chimica Acta, 2023)

Longitudinal expression profiles of flavonoid synthesis-related genes and their correlations with contents of flavonoids including anthocyanins in purplish-green aerial stems of Panax notoginseng - Hongling Zhang; Guiqiong Li; Min Jiang; Changling Zhao; Pengyu Zhao; Chen Wang; Guosong Wen; Feng Zhou; Wenhua Dongchen; Shaozhong Xu; Ting Mu; Fanlai Meng; et al. (Acta Physiologiae Plantarum, 2023)

Comprehensive genetic analysis reveals seed germination activity-related QTL and meta-QTL in rice (Oryza sativa L.) - Pen Li; Hualong Liu; Haoran Wen; Luomiao Yang; Ziqi Chen; Hongliang Zheng; Wei Xin; Dezhuang Zhang; Jingguo Wang; Detang Zou (Genetic Resources and Crop Evolution, 2022)

Effects of Bacillus sp. and Lactobacillus sp. combination as a water additive on the culture pond water and growth performance of hybrid grouper (Epinephelus fuscoguttatus × Epinephelus polyphekadion) - Jianpeng Huang; Eric Amenyogbe; Guanghai Ou; Yu Li; Zhenwei Wen; Xingtao Jiang; Gang Chen (Frontiers in Marine Science, 2022)
The individual Probiotic application has become increasingly widespread in aquaculture and has been extensively studied. However, investigating probiotics as water additives in the grouper culture is still lacking. This study evaluated the functional efficacy of the Bacillus subtilis CICC 10071 (3 × 1011 CFU / g) and Lactobacillus sp. (8 × 1011 CFU / g) combination in a 1:1 ratio on the rearing water quality, water microbial community structure, and growth performance of hybrid grouper. Depending on the additive concentrations of probiotics, we designed four groups, each in triplicate: control (WT, 0g/m3), low concentration (WL, 0.038g/m3), middle concentration (WM, 0.075g/m3), and high concentration (WH, 0.113g/m3). The result shows that throughout the 22-day feeding period, the water supplementation of probiotics significantly decreased Ammonia (NH3) and nitrite (NO2-) in culture water. Final weight (FW), Specific growth rate (SGR), and Weight gain rate (WGR) in treated groups were higher than that in the control group (P<0.05). Analysis of water microbiota revealed that the dominant phylum Bacteroidetes, Proteobacteria, Cyanobacteria, and Actinobacteria enriched in the culture water. Furthermore, we found that the Probiotics combination could significantly reduce the abundance of Cetobacterium (phyla Fusobacteria) related to ammonia and nitrite. The Phylogenetic Investigation of Communities by Reconstruction of Unobserved States 2 (PICRUSt2) also shows that the 'metabolism of other amino acids and ‘Fatty acid biosynthesis’ functions of water microbiota were reinforced by the addition of the probiotic combination. Thus, the probiotic combination exhibited a range of advantages in the grouper culture environment, and further in-depth studies are needed.

The signal-to-cutoff ratios to predict HCV infection among people who inject drugs - Bing Chen; Ling-yu Gao; Zhong-hui Ma; Hao Chang; Li-jian Pei; Qiang Zhou; Wen-ge Xing (VirusDisease, 2022)

MdbHLH51 plays a positive role in anthocyanin accumulation in ‘Red Delicious’ apples - Gai-Xing Ning; Wen-Fang Li; Ming-Yu Chu; Zong-Huan Ma; Ping Wang; Juan Mao; Bai-Hong Chen (Trees, 2022)

A Fundamental Role of Slope Aspect and Elevation in Controlling Diversity Patterns of Soil Bacterial Communities: Insights from an Arid-Montane Ecosystem in China - Long-Fei Chen; Jun-Qia Kong; Zhi-Bin He; Wen-Zhi Zhao; Ming-Dan Song; Yue-Mei Li; Yuan Gao; Shu-Ping Yang (Journal of Soil Science and Plant Nutrition, 2022)

AIoT-Based Ergometer for Physical Training in Frail Elderly with Cognitive Decline: A Pilot Randomized Control Trial - Chih-Chun Lin; Li-Chieh Kuo; Yu-Sheng Lin; Chia-Ming Chang; Fang Wen Hu; Yi-Jing Chen; Chun-Tse Lin; Fong-Chin Su (Journal of Medical and Biological Engineering, 2022)
Purpose Reduced physical activity is reported in the elderly, especially in institutional residents. Institutionalized older adults exhibit a high prevalence of frailty. In this work, we developed an artificial intelligence of things (AIoT)-based feedback assistive strengthening ergometer (AIFASE), for the physical strengthening of the elderly with intelligent assistance. Methods We conducted a 12-week intervention in a long-term care facility. In total, 16 participants (84.38 ± 6.0 years; 4 males and 12 females) were recruited with 1:1 randomization of exercise to control groups. The muscle strength of the lower extremities, timed up and go test (TUG), and Short-form Physical Performance Battery (SPPB) of the participants were measured. The AIFASE system allows the clinical staff to record the personal physical performance of the elderly and generates personalized exercise prescriptions accordingly. AIFASE also displays the current usage status of all ergometers and the users’ physiological conditions. The algorithms were developed to generate warning alerts when the training workload was too large by personal physiological detection. AIFASE automatically customized the exercise prescription according to the user’s exercise performance. Results After a 12-week AIFASE intervention, the intervention group exhibited significant improvements in the strength of the hip flexor, Semi-Tandem Stand, and Tandem Stand. Conclusion In this study, we developed an AIoT ergometer that delivered customized physical training prescriptions to improve the physical performance of long-term care facility residents. We believe that the application of AIFASE will help improve the quality of institutional care.

First Detection and Molecular Identification of Entamoeba bovis in Farm-Raised Sika Deer from Anhui Province, China - Xin-chao Liu; Qi Ren; Jie Guo; Dong-qian Chen; Qiao-qiao Li; Xin-yu Luo; You-fang Gu; Wen-chao Li (Acta Parasitologica, 2022)

Transcriptome analysis of knockout mutants of rice seed dormancy gene OsVP1 and Sdr4 - Wen-Qiang Chen; Da-Pu Liu; Zhi-Xin Li; Kai Chen; Ju Luo; Jian-Long Xu (Plant Cell Reports, 2022)

Correction to: Increased Soluble Epoxide Hydrolase Activity Positively Correlates with Mortality in Heart Failure Patients with Preserved Ejection Fraction: Evidence from Metabolomics - Liyuan Peng; Ziping Song; Chengcheng Zhao; Kudusi Abuduwufuer; Yanwen Wang; Zheng Wen; Li Ni; Chenze Li; Ying Yu; Yi Zhu; Hualiang Jiang; Jinshan Shen; et al. (Phenomics, 2022)

Further refinements of a continuous radon monitor for surface ocean water measurements - Chunqian Li; Shibin Zhao; Chenglun Zhang; Meng Li; Jinjia Guo; Natasha T. Dimova; Tong Yang; Wen Liu; Guangquan Chen; Huaming Yu; Bochao Xu (Frontiers in Marine Science, 2022)
Radon is an excellent natural tracer for studying various geophysical processes. In the past centuries, radon isotopes measurement approaches for marine research have been fully developed but still suffer limitations. Here we present the setup and validation of an improved continuous online measurement system (PIC-ORn) to measure dissolved radon in the surface ocean and other water bodies. We demonstrated that the PIC measurement efficiency is ~2 times higher than a RAD7 and is less affected by relative humidity and produces reliable results. Laboratorial measurements indicated that the new PIC-ORn system responded timely to the change of radon activities in water. The new system was successfully deployed during a cruise to the northwest Pacific Ocean in June 2021. Despite low radon-in-water activities, the results obtained by the new PIC-ORn system matched the traditional measurement systems within the estimated uncertainties. The PIC-ORn detector takes advantage of higher efficiency, lower cost, and power consumption, and is less affected by air moisture. The new system does not rely on drying units, further reducing on-site supervision, which would benefit the researches in submarine groundwater advection and diffusion and ocean-atmosphere gas exchange.

Associations of single and multiple organophosphate pesticide exposure with female infertility in the USA: data from the 2015–2018 National Health and Nutrition Examination Survey - Yingying Wu; Xueqiong Weng; Shan Liu; Yuxuan Tan; Huanzhu Liang; Yexin Li; Lin Wen; Qian Chen; Chunxia Jing (Environmental Science and Pollution Research, 2022)

Local domestication of soybean leads to strong root selection and diverse filtration of root-associated bacterial communities - Wen Luo; Jieli Wang; Yuanli Li; Chang Wang; Shanshan Yang; Shuo Jiao; Gehong Wei; Weimin Chen (Plant and Soil, 2022)

Application of regional citrate anticoagulation in patients at high risk of bleeding during intermittent hemodialysis: a prospective multicenter randomized controlled trial - Xiaoyan Tang; Dezheng Chen; Ling Zhang; Ping Fu; Yanxia Chen; Zhou Xiao; Xiangcheng Xiao; Weisheng Peng; Li Cheng; Yanmin Zhang; Hongbo Li; Kehui Li; et al. (Journal of Zhejiang University-SCIENCE B, 2022)

History of collision between the Jiamusi and Songliao blocks: new constraints from the Luobei complex, NE China - Zhuo Chen; Gong-Yu Li; Wen-Jiao Xiao; Jian-Bo Zhou (International Journal of Earth Sciences, 2022)

The association between hearing threshold and urinary personal care and consumer product metabolites in middle-aged and elderly people from the USA - Yan-Peng Fu; Wen-Yu Chen; Li-Qing Guo; Ya-Qiong Zhu; Jia-Sheng Yuan; Yue-Hui Liu (Environmental Science and Pollution Research, 2022)

Construction and evaluation of curcumin upconversion nanocarriers decorated with MnO2 for tumor photodynamic therapy - Xinru Chen; Quandong Li; Zipeng Huang; Wen Lin; Yan Ma (Drug Delivery and Translational Research, 2022)

Dongia deserti sp. nov., Isolated from the Gurbantunggut Desert Soil - Chun-Yan Lu; Lei Dong; Dong Wang; Shuai Li; Bao-Zhu Fang; Ming-Xian Han; Feng Liu; Hong-Chen Jiang; Iftikhar Ahmed; Wen-Jun Li (Current Microbiology, 2022)

A histological study of vascular wall resident stem cells in venous malformations - Hou-Fu Xia; Wen-Qiang Lai; Gao-Hong Chen; Ye Li; Qi-Hui Xie; Yu-Lin Jia; Gang Chen; Yi-Fang Zhao (Cell and Tissue Research, 2022)

Complete genome sequence analysis of Paris alphapartitivirus 1: a novel member of the genus Alphapartitivirus infecting Paris polyphylla var. yunnanensis - Zhe Wang; Rex Frimpong Anane; Zeli Chen; Like Gao; Shangyun Li; Bifan Chu; Guosong Wen; Mingfu Zhao (Archives of Virology, 2022)

The correlation of CD70 in immune characteristics and drug therapy of pan-cancer - Yang Yang; Jinghong Chen; Mingyang Feng; Yujiao Wang; Weiting Liao; Qiuji Wu; Feng Wen; Qiu Li (Human Cell, 2022)

Early Cretaceous rapid exhumation processes in the southern Great Xing’an Range, NE China: implications for extensional geodynamics - Wen Zhang; Shuangfeng Zhao; Wen Chen; Jingbo Sun; Ze Shen; Qiuyi Du; Zhi Li (International Geology Review, 2022)

Experimental study on the process of overtopping breach of concrete-faced sand-gravel dam - Yanlong Li; Wen Qiu; Zuyu Chen; Lifeng Wen; Lin Wang (European Journal of Environmental and Civil Engineering, 2022)

Repeated Sevoflurane Exposures in Neonatal Rats Increased the Brain Vulnerability to Future Stress Exposure and Resulted in Fear Extinction Deficit - Ben-zhen Chen; Li-hua Jiang; Ling Tan; Wen-qin Zhou; Yu-chao Shang; Fang Li; Bin Liu (Neurotoxicity Research, 2022)

First report of Bacillus velezensis JK-F2 for the biological control of crown gall in kiwifruit - Ting Ting Chen; Fei Ran; Jin Qiao Shi; Fei Xu Mo; Xian Hui Yin; Zhi Bo Zhao; Zhu Zhu Zhang; Wen Zhi Li; Li Nan He; You Hua Long (Journal of Plant Diseases and Protection, 2022)

Fracture Mechanical Properties of Three—Dimensional Irregular Sandstone Particles Based on Digital-Image - Kai-wen Shi; Yu-jun Zuo; Wen-ji-bin Sun; Hao Liu; Jian-yun Lin; Tao-tao Li; Bin Chen; Lu-lin Zheng (Geotechnical and Geological Engineering, 2022)

Clinical profiles and antimicrobial resistance patterns of invasive Salmonella infections in children in China - Wen Song; Qingwen Shan; Yue Qiu; Xianyao Lin; Chunhui Zhu; Zhiqiang Zhuo; Caihong Wang; Jianning Tong; Rui Li; Chaomin Wan; Yu Zhu; Minxia Chen; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2022)
Invasive Salmonella infections result in a significant burden of disease including morbidity, mortality, and financial cost in many countries. Besides typhoid fever, the clinical impact of non-typhoid Salmonella infections is increasingly recognized with the improvement of laboratory detection capacity and techniques. A retrospective multicenter study was conducted to analyze the clinical profiles and antimicrobial resistance patterns of invasive Salmonella infections in hospitalized children in China during 2016–2018. A total of 130 children with invasive Salmonella infections were included with the median age of 12 months (range: 1–144 months). Seventy-nine percent of cases occurred between May and October. Pneumonia was the most common comorbidity in 33 (25.4%) patients. Meningitis and septic arthritis caused by nontyphoidal Salmonella (NTS) infections occurred in 12 (9.2%) patients and 5 (3.8%) patients. Patients < 12 months (OR: 16.04) and with septic shock (OR: 23.4), vomit (OR: 13.33), convulsion (OR: 15.86), C-reactive protein (CRP) ≥ 40 g/L (OR: 5.56), and a higher level of procalcitonin (PCT) (OR: 1.05) on admission were statistically associated to an increased risk of developing meningitis. Compared to 114 patients with NTS infections , 16 patients with typhoid fever presented with higher levels of CRP and PCT ( P < 0.05). The rates of resistance to ampicillin, sulfamethoxazole/trimethoprim, ciprofloxacin, and ceftriaxone among Salmonella Typhi and NTS isolates were 50% vs 57.3%, 9.1% vs 24.8%, 0% vs 11.2%, and 0% vs 9.9%, respectively. NTS has been the major cause of invasive Salmonella infections in Chinese children and can result in severe diseases. Antimicrobial resistance among NTS was more common.

Maternal exposure to cooking oil fumes during pregnancy and autistic‐like behaviors in Chinese preschoolers - Jian-Hui Yang; Esben Strodl; Chuan-An Wu; Xiang-Yu Hou; Xiao-Na Yin; Guo-Min Wen; Deng-Li Sun; Dan-Xia Xian; Jing-Yi Chen; Ying-Jie Chen; Jing Chen; Wei-Qing Chen (Environmental Science and Pollution Research, 2022)

Ambient gaseous pollutant exposure and incidence of visual impairment among children and adolescents: findings from a longitudinal, two-center cohort study in China - Li Chen; Jing Wei; Tao Ma; Di Gao; Xijie Wang; Bo Wen; Manman Chen; Yanhui Li; Jun Jiang; Lijuan Wu; Weiming Li; Xiangtong Liu; et al. (Environmental Science and Pollution Research, 2022)

An update on microneedle-based systems for diabetes - Wen Xuan Li; Xiao Peng Zhang; Bo Zhi Chen; Wen Min Fei; Yong Cui; Can Yang Zhang; Xin Dong Guo (Drug Delivery and Translational Research, 2022)

Antifungal and Antibiofilm In Vitro Activities of Ursolic Acid on Cryptococcus neoformans - Wen-Jing Wang; Chan-Chan Liu; Yan-Tong Li; Miao-Qian Li; Yu-Ting Fu; Xin-Chen Li; Jie-Kang; Wei-Dong Qian (Current Microbiology, 2022)

The effect of Fe–Ti oxide separation on iron isotopic fractionation during basalt differentiation - Jian Zhao; Xiao-Jun Wang; Li-Hui Chen; Takeshi Hanyu; Jin-Hua Shi; Xiao-Wen Liu; Hiroshi Kawabata; Lie-Wen Xie (Contributions to Mineralogy and Petrology, 2022)

Motor imagery evokes strengthened activation in sensorimotor areas and its effective connectivity related to cognitive regions in patients with complete spinal cord injury - Ling Wang; Xuejing Li; Weimin Zheng; Xin Chen; Qian Chen; Yongsheng Hu; Lei Cao; Jian Ren; Wen Qin; Jie Lu; Nan Chen (Brain Imaging and Behavior, 2022)

Histone methyltransferase GLP epigenetically activates GPCPD1 to sustain cancer cell metastasis and invasion - He Wen; Minghui Shu; Jia-Yi Chen; Xiaofan Li; Qian Zhu; Jun Zhang; Yuan Tian; Xiaopeng Lu; Wei-Guo Zhu (Genome Instability & Disease, 2022)
Disordered choline metabolism is associated with tumor progression. Glycerophosphocholine phosphodiesterase 1 (GPCPD1) is critical for cleaving glycerophosphocholine (GPC) to produce choline. However, whether and how GPCPD1 is epigenetically regulated remains largely unknown. In the current study, we report that histone H3 lysine 9 (H3K9) methyltransferase GLP (G9a-like Protein) is essential for transcriptional activation of GPCPD1 through H3K9me1 to promote tumor cell migration and invasion. Knocking down GLP or inhibiting its methyltransferase activity impaired GPCPD1 expression and decreased the choline levels. Importantly, we confirmed that both GPCPD1 and choline levels are positively correlated with cancer cell migration. The reduced migration and invasion of GPCPD1-knockdown cells were rescued by choline treatment. Interestingly, GPCPD1 gene expression was found regulated by transcription factor Krüppel-like Factor 5 (KLF5). KLF5 recruitment was GLP-dependent and was indispensable for GPC-induced GPCPD1 expression. These data suggest that GLP promotes tumor cell migration and invasion by transcriptionally activating GPCPD1 . GLP and KLF5 are potential therapeutic targets in future cancer treatment.

Molecular studies of cellulose synthase supercomplex from cotton fiber reveal its unique biochemical properties - Xingpeng Wen; Yufeng Zhai; Li Zhang; Yanjun Chen; Zhiyuan Zhu; Gang Chen; Kun Wang; Yuxian Zhu (Science China Life Sciences, 2022)

Altered Retinal Dopamine Levels in a Melatonin-proficient Mouse Model of Form-deprivation Myopia - Kang-Wei Qian; Yun-Yun Li; Xiao-Hua Wu; Xue Gong; Ai-Lin Liu; Wen-Hao Chen; Zhe Yang; Ling-Jie Cui; Yun-Feng Liu; Yuan-Yuan Ma; Chen-Xi Yu; Furong Huang; et al. (Neuroscience Bulletin, 2022)

Evaluation of aquatic ecological health of sluice-controlled rivers in Huai River Basin (China) using evaluation index system - Hao Chen; Wen Li; Qiting Zuo; Yongyong Zhang; Shikui Liang (Environmental Science and Pollution Research, 2022)

Impacts of Mercury Exposure Levels and Sources on the Demethylation of Methylmercury Through Human Gut Microbiota - Xian-Feng Yang; Shao-Chen Yang; Fu-Li Wen; Lin Feng; Bo Meng; Hai-Yan Hu; Bao-Lin Wang; Jun Li; Alexandre J. Poulain; Ping Li (Bulletin of Environmental Contamination and Toxicology, 2022)

Teratogenicity of 30 nm Aluminum Oxide Nanoparticles (Al2O3NPs) in Rats by Gavage - Yuqiu Gao; Pingjing Wen; Huafeng Chen; Yujia Wei; Haichen Cui; Jinfeng Ma; Jinyue Li; Guangqiu Qin (Biological Trace Element Research, 2022)

Effect of Zn2+-Cu2+ combined heavy metal on mechanical properties and microstructure of clayey soil - Qiang Ma; Nian-ze Wu; Heng-lin Xiao; Wen-tao Li; Jun-chen Xiang (Journal of Mountain Science, 2022)

Stability analysis of complex terrain slope based on multi-source point cloud fusion - Wen-bo Zan; Wen-jie Zhang; Ning Wang; Chun-chen Zhao; Qian Yang; Hao Li (Journal of Mountain Science, 2022)

Geophysical characteristics of anthracites with various structures: a case study on the southern Qinshui Basin, north China - Juan Teng; Zhigang Wen; Chen Li; Lingye Meng (Frontiers of Earth Science, 2022)

Effect of confining pressure on the fracture mechanical properties of multi-particle sandstone - Kai-wen Shi; Yu-jun Zuo; Wenjibin Sun; Hao Liu; Chao Pan; Taotao Li; Bin Chen; Jian-yun Lin (Arabian Journal of Geosciences, 2022)

In-situ radon-in-water detection for high resolution submarine groundwater discharge assessment - Shibin Zhao; Meng Li; William C. Burnett; Kai Cheng; Chunqian Li; Jinjia Guo; Songling Yu; Wen Liu; Tong Yang; Natasha T. Dimova; Guangquan Chen; Zhigang Yu; et al. (Frontiers in Marine Science, 2022)
Submarine groundwater discharge (SGD), including both land-based fresh groundwater that enters the ocean from coastal aquifers as well as recirculated seawater that is continuously recharged and discharged on the seabed, has been considered as an important component of the global water and biogenic element (e.g., nitrogen, phosphorus, silicon and carbon) sources and a significant pathway for material exchange at the land-sea interface of coastal ecosystems. Some researchers reported that SGD associated nutrient additions to coastal waters have caused unwanted ecological issues, including red tides, coastal acidification and hypoxia. Natural radon isotope ( 222 Rn, t 1/2 = 3.8 d ) is an excellent tracer for studying SGD and other oceanographic processes including air-sea gas exchange, sediment-water diffusion, and earthquake prediction. However, the conventional radon measurement methods suffer many technical disadvantages. We consequently developed a convenient submersible radon determination approach (“OUC-Rn”) using a commercial pulsed ionization chamber (PIC) radon sensor and gas extraction membrane module to produce high precision and high resolution observations. We demonstrate the radon degassing efficiency of the membrane contactor is comparable to the shower-head type air-water exchanger but is independent of operating position. The radon measurement efficiency of the PIC is 2-fold higher than the RAD7 detector and is far less influenced by moisture. We successfully deployed the system in 2.5 meters water depth over a 100 hours period in an anthropogenic influenced bay. Based on our high temporal resolution observations, the SGD flux was estimated to be 0-43.0 cm/d (mean: 25.4 ± 14.5 cm/d). The SGD fluxes pattern plotted together with the tidal variations revealed that tidal pumping may be the main force driving seawater recirculation into aquifers and thus affecting nutrient, carbon and other dissolved matters dynamics in coastal regions.

Long-term changes in zooplankton in the Changjiang estuary from the 1960s to 2020 - Ping Du; Wen-Jian Ye; Bang-Ping Deng; Ming Mao; Yuan-Li Zhu; Fang-Ping Cheng; Zhi-Bing Jiang; Lu Shou; Quan-Zhen Chen (Frontiers in Marine Science, 2022)
The Changjiang estuary (CJE) is a large estuary that is affected by multiple anthropogenic stressors and climate change. The long-term trend of zooplankton in the CJE is an important indicator of the ecological response to stressors. We applied the Mann–Kendall trend analysis and Pettitt test to detect the trend and breakpoints of the biomass of the large mesozooplankton (LMZ; 505–20 000 μm) in four seasons, abundance of main LMZ taxa in summer from the 1960s to 2020, and abundance of dominant species in summer from 2000 to 2020 in the CJE. Results showed that LMZ biomass increased significantly during spring and summer, and the breakpoints both occurred in the 1980s. After the breakpoint, the mean biomass increased from 142.88 to 429.42 mg/m 3 in spring and from 296.28 to 723.92 mg/m 3 in summer. After 2000, the abundance of Copepoda in summer increased by more than 10 times compared to the 1960s. Under the conditions of warming and increased dinoflagellate abundance in the CJE, the abundance of the warm-water and omnivorous small calanoid copepod Paracalanus aculeatus increased significantly. Meanwhile, the significant decrease in the abundance of the temperate brackish species Labidocera euchaeta was probably mainly related to warming. The rapid changes in LMZ biomass during the late 1980s and mid-1990s is probably the result of a combination of enhanced bottom–up support, reduced top–down pressure, and promotion of temperature. This study provides scientific evidence and insights into the adaptive management of the Changjiang Basin.

PTEN-induced kinase 1 enhances the reparative effects of bone marrow mesenchymal stromal cells on mice with renal ischaemia/reperfusion-induced acute kidney injury - Chenyu Lin; Wen Chen; Yong Han; Yujie Sun; Xiaoqiong Zhao; Yuan Yue; Binyu Li; Wenmei Fan; Tao Zhang; Li Xiao (Human Cell, 2022)
Acute kidney injury (AKI) is a common severe acute syndrome caused by multiple factors and is characterized by a rapid decline in renal function during a short period. Bone marrow mesenchymal stromal cells (BMSCs) are effective in treating AKI. However, the mechanism of their beneficial effects remains unclear. PTEN-induced kinase 1 (PINK1) may play an important role in kidney tissue repair. In this study, we explored the effect of PINK1 overexpression on enhancing BMSC-mediated repair of AKI. In this study, ischaemia/reperfusion-induced AKI (IRI-AKI) in mice and a hypoxia-reoxygenation model in cells were established, and the indices were examined by pathology and immunology experiments. After ischaemia/reperfusion, PINK1 overexpression reduced apoptosis in injured kidney tissue cell, decreased T lymphocyte infiltration, increased macrophage infiltration, and alleviated the inflammatory response. PINK1 relieved the stress response of BMSCs and renal tubular epithelial cells (RTECs), reduced apoptosis, altered the release of inflammatory factors, and reduced the proliferation of peripheral blood mononuclear cells (PBMCs). In conclusion, BMSCs and RTECs undergo stress responses in response to hypoxia, inflammation and other conditions, and overexpressing PINK1 in BMSCs could enhance their ability to resist these stress reactions. Furthermore, PINK1 overexpression can regulate the distribution of immune cells and improve the inflammatory response. The regulation of mitochondrial autophagy during IRI-AKI maintains mitochondrial homeostasis and protects renal function. The results of this study provide new strategies and experimental evidence for BMSC-mediated repair of IRI-AKI.

Microbial community characteristics of the intestine and gills of medium-form populations of Sthenoteuthis oualaniensis in the South China Sea - Xiaojuan Hu; Haochang Su; Peng Zhang; Zuozhi Chen; Yu Xu; Wujie Xu; Jie Li; Guoliang Wen; Yucheng Cao (Frontiers in Marine Science, 2022)
Sthenoteuthis oualaniensis (purpleback squid) is an excellent biological resource in the South China Sea. However, the microbiological characteristics of this South China Sea squid, especially those of the medium-form of different sexes and gonadal maturities, are poorly understood. In this study, the characteristics of the bacterial community in the intestinal and gill tissues of female and male S. oualaniensis with different gonadal maturities, collected from the Nansha Sea of China in spring 2020, were analyzed. The results showed that Tenericutes, Proteobacteria, Firmicutes, and Bacteroidetes were the dominant phyla in the intestinal microbial samples of female immature gonad (FN), male immature gonad (MN), and male sexual maturity (MY) samples of the S. oualaniensis populations. Proteobacteria, Firmicutes, Bacteroidetes, and Tenericutes were the dominant phyla in the intestinal microbial sample of the female sexual maturity (FY) group. The microbial community in the gills differed from that of the intestinal flora. The dominant phyla in the gill samples were Proteobacteria, Firmicutes, and Bacteroidetes, regardless of sex or gonadal maturity. According to the random forest analysis, the gill samples had significantly ( p <0.001) more Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways in the top 20 than the intestinal samples. Correlation analysis showed that the mantle length of S. oualaniensis was significantly ( p <0.05) negatively correlated with the abundance of Tenericutes, but significantly ( p <0.01) positively correlated with Firmicutes and Bacteroidetes. The mantle length of FY was significantly ( p <0.05) longer than that of the other types. The results indicated that the differences in the intestinal bacterial community were related to the growth and feeding characteristics of S. oualaniensis of different sexes and maturities.

Effect of dietary soybean meal on growth performance, apparent digestibility, intestinal digestive enzyme activity and muscle growth-related gene expression of Litopenaeus vannamei - Kai Peng; Xiaoying Chen; Huijie Lu; Jichen Zhao; Yihong Chen; Chaozheng Li; Huo Li; Wen Huang (Frontiers in Marine Science, 2022)
Soybean meal is one of the major components of aquatic animal diets, whereas little information is available about the evaluation of soybean meal growth suppression mode of action. A 42-day feeding trial was performed to assess the effects of dietary soybean meal on growth performance, apparent digestibility, intestinal digestive enzyme activity, and muscle growth–related gene expression of Litopenaeus vannamei . A total of 600 shrimp were randomly distributed into 20 tanks with 30 shrimp per tank and four tanks per group. The soybean meal was added to the diets at the rate of 20% (T20), 28% (T28), 35% (T35), 42% (T42), and 50% (T50), respectively. Shrimp were fed with apparent satiation three times daily. Results indicated that the final body weight, weight gain rate, specific growth rate, feed intake, intestinesomatic index, dressed weight percentage, and the apparent digestibility coefficients of dry matter, crude protein, crude lipid, and ash were linearly decreased ( p < 0.05), but feed coefficient was linearly increased ( p < 0.05) as dietary soybean meal increased from 20% to 50%. The intestinal trypsin and amylase activities were decreased ( p < 0.05) as dietary soybean meal increased from 20% to 50%, and reached significance at the level of 35%, 42%, and 50%. Shrimp fed with T20 had higher ( p < 0.05) intestinal lipase activity than those fed with other diets. The mRNA relative expression of growth hormone, myogenic regulatory factor 5, and target of rapamycin was downregulated ( p < 0.05) as dietary soybean meal increased from 20% to 50%. To conclude, dietary soybean meal exceeded 28% significantly inhibited growth performance of L. vannamei , mainly due to the negative impact of soybean meal on digestion and feed utilization and also the inhibition on the muscle growth and related gene expressions.

Microbial Community Structure and Metabolic Characteristics of Intestine and Gills of Dwarf-Form Populations of Sthenoteuthis oualaniensis in South China Sea - Xiaojuan Hu; Haochang Su; Peng Zhang; Zuozhi Chen; Yu Xu; Wujie Xu; Jie Li; Guoliang Wen; Yucheng Cao (Fishes, 2022)
Sthenoteuthis oualaniensis is an important biological resource in the South China Sea. However, the microbiological characteristics of this squid, especially those of the dwarf-form, are poorly understood. This study was conducted to analyze the microbial community structure and metabolic characteristics of the intestinal and gill tissues of dwarf-form populations of S. oualaniensis. The dwarf-form squids of different sexes and gonadal maturities were collected from South China Sea in spring 2020. Results showed that Mycoplasma was the most dominant group of bacteria in the intestinal samples of the females with immature gonads (FN), females at sexual maturity (FY), and males at sexual maturity (MY) and the second-highest relative abundance group in males with immature gonads (MN). The microbial community structure in squid gills differed from that of intestinal flora. The BD1-7 clade was the dominant genus in gill samples of all groups. Furthermore, the microbial community activities in gills were higher than in intestinal groups, especially FYG. The larger dwarf-form populations had microbial communities with more robust utilization of carbon sources, assessed via average well color development (AWCD). Correlation and redundancy analysis determined that AWCD significantly positively correlated with the relative abundance of BD1-7 clade (p

Two new pyridine derivatives and two new furan derivatives from Irpex lacteus - Qiong Chen; Meng Wang; Xue-Wen Yi; Zheng-Hui Li; Tao Feng; Ji-Kai Liu (Natural Product Research, 2022)

Correction to: Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated Encephalopathy by Promoting Ferroptosis Through Regulating miR-9-5p/ TFRC and GOT1 Axis - Xue-biao Wei; Wen-qiang Jiang; Ju-hao Zeng; Lin-qiang Huang; Hong-guang Ding; Yuan-wen Jing; Yong-li Han; Yi-chen Li; Sheng-long Chen (Molecular Neurobiology, 2022)

Updated taxonomy of Chinese Clavaria subg. Syncoryne (Clavariaceae, Agaricales): description of two new species and one newly recorded species - Jun Yan; Gui-Wu Li; Wen-Hao Liu; Zuo-Hong Chen; Ping Zhang (Mycological Progress, 2022)

Ketone Body Rescued Seizure Behavior of LRP1 Deficiency in Drosophila by Modulating Glutamate Transport - Jin-Ming Zhang; Ming-Jie Chen; Jiong-Hui He; Ya-Ping Li; Zhi-Cai Li; Zi-Jing Ye; Yong-Hui Bao; Bing-Jun Huang; Wen-Jie Zhang; Ping Kwan; Yu-Ling Mao; Jing-da Qiao (Journal of Molecular Neuroscience, 2022)

Feed types affect the growth, nutrient utilization, digestive capabilities, and endocrine functions of Megalobrama amblycephala: a comparative study between pelleted and extruded feed - Chao-Fan He; Xiang-Fei Li; Guang-Zhen Jiang; Ling Zhang; Miao Sun; Ya-Ping Ge; Wei-Liang Chen; Wen-Bin Liu (Fish Physiology and Biochemistry, 2022)

Integrating life cycle assessment and a farmer survey of management practices to study environmental impacts of peach production in Beijing, China - Ziyue Li; Yongliang Chen; Fanlei Meng; Qi Shao; Mathew R. Heal; Fengling Ren; Aohan Tang; Jiechen Wu; Xuejun Liu; Zhenling Cui; Wen Xu (Environmental Science and Pollution Research, 2022)

Association of cognitive impairment and reduced cortical thickness in prefrontal cortex and anterior cingulate cortex with treatment-resistant depression - Mu-Hong Chen; Wan-Chen Chang; Pei-Chi Tu; Wei-Chen Lin; Cheng-Ta Li; Wen-Sheng Huang; Ya-Mei Bai; Shih-Jen Tsai; Tung-Ping Su (Brain Imaging and Behavior, 2022)

White matter alterations in heart-kidney imbalance insomnia and Jiao-Tai-Wan treatment: A diffusion-tensor imaging study - Jie Chen; Yanxuan Li; Nengzhi Xia; Caiyun Wen; Tianyi Xia; Yuandi Zhuang; Mengmeng Jiang; Yilan Xiang; Mingyue Zhang; Chenyi Zhan; Yunjun Yang; Zhengzhong Yuan; et al. (Brain Imaging and Behavior, 2022)
Previous studies have reported changes in white matter microstructures in patients with insomnia. However, few neuroimaging studies have focused specifically on white matter tracts in insomnia patients after having received treatment. In this prospective study, diffusion-tensor imaging was used in two samples of heart-kidney imbalance insomnia patients who were treated with placebo or Jiao-Tai-Wan, a traditional Chinese medicine commonly used to treat heart-kidney imbalance insomnia, to assess the changes in white matter tracts. Tract-based spatial statistical analyses were first applied to compare the changes in mean diffusivity and fractional anisotropy of white matter between 75 heart-kidney imbalance insomnia patients and 41 healthy control participants. In subsequent randomized, double-blind, placebo-controlled trials, comparisons of mean diffusivity and fractional anisotropy were also performed in 24 heart-kidney imbalance insomnia patients (8 males; 16 females; 42.5 ± 10.4 years) with Jiao-Tai-Wan and 26 heart-kidney imbalance insomnia patients (11 males; 15 females; 39.7 ± 9.4 years) with a placebo, with age and sex as covariates. Fractional anisotropy values in left corticospinal tract were increased in heart-kidney imbalance insomnia patients. Heart-kidney imbalance insomnia patients showed lower mean diffusivity and fractional anisotropy values of several white matter tracts than healthy control participants, such as the bilateral anterior limb of internal capsule, bilateral superior longitudinal fasciculus and bilateral posterior corona radiata. After being treated with Jiao-Tai-Wan, heart-kidney imbalance insomnia patients showed a trend towards reduced fractional anisotropy values in the left corticospinal tract. Jiao-Tai-Wan may improve the sleep quality by reversing the structural changes of the left corticospinal tract caused by heart-kidney imbalance insomnia.

Assessing the joint effects of brain aging and gut microbiota on the risks of psychiatric disorders - Huijie Zhang; Li Liu; Shiqiang Cheng; Yumeng Jia; Yan Wen; Xuena Yang; Peilin Meng; Chun’e Li; Chuyu Pan; Yujing Chen; Zhen Zhang; Jingxi Zhang; et al. (Brain Imaging and Behavior, 2022)

Lead Exposure in Developmental Ages Promotes Aβ Accumulation by Disturbing Aβ Transportation in Blood-Cerebrospinal Fluid Barrier/Blood–Brain Barriers and Impairing Aβ Clearance in the Liver - Can-Can Zhou; Xu-Jie Wang; Zi-Chen Li; Wen-Jie Lu; Yun-Ting Zhang; Fu-Ming Shen; Dong-Jie Li (Biological Trace Element Research, 2022)

Evansella halocellulosilytica sp. nov., an alkali-halotolerant and cellulose-dissolving bacterium isolated from bauxite residue - Guo-Hong Liu; Manik Prabhu Narsing Rao; Qian-Qian Chen; Jian-Mei Che; Huai Shi; Bo Liu; Wen-Jun Li (Extremophiles, 2022)

Long noncoding RNA TRG-AS1 protects against glucocorticoid-induced osteoporosis in a rat model by regulating miR-802-mediated CAB39/AMPK/SIRT-1/NF-κB axis - Wen Liu; Guojuan Li; Jing Li; Wei Chen (Human Cell, 2022)

Application of an improved hollow fiber liquid phase microextraction technique coupled to LC-MS/MS to studying migration of fluorescent whitening agents from plastic food contact materials - Wen-Li Zhou; Li Ding; Yun-Hui Cheng; Zhou Xu; Mao-Long Chen; Xian-Shu Fu (Food Additives & Contaminants: Part A, 2022)

Preliminary establishment of a mass movement warning system for Taiwan using the soil water index - Chi-Wen Chen; Ching Hung; Guan-Wei Lin; Jun-Jih Liou; Shih-Yao Lin; Hsin-Chi Li; Yung-Ming Chen; Hongey Chen (Landslides, 2022)

Dioxin emission and distribution from cement kiln co-processing of hazardous solid waste - Wen-Wen Ye; Peng-Tao Cai; Ming-Xiu Zhan; Wen-Tao Jiao; Xu-Xu; Jian-Ying Fu; Tong Chen; Xiao-Dong Li (Environmental Science and Pollution Research, 2022)

The impacts of ambient relative humidity and temperature on supine position-related obstructive sleep apnea in adults - Wen-Te Liu; Yuan-Hung Wang; Li-Te Chang; Chih-Da Wu; Dean Wu; Cheng-Yu Tsai; Chen-Chen Lo; Kang Lo; Kian Fan Chung; Ta-Yuan Chang; Kai-Jen Chuang; Yueh-Lun Lee; et al. (Environmental Science and Pollution Research, 2022)

Short-term effect of sulfur dioxide (SO2) change on the risk of tuberculosis outpatient visits in 16 cities of Anhui Province, China: the first multi-city study to explore differences in occupational patients - Xin-Qiang Wang; Jia-Wen Zhao; Kang-Di Zhang; Wen-Jie Yu; Jie Wang; Ying-Qing Li; Xin Cheng; Zhen-Hua Li; Yi-Cheng Mao; Cheng-Yang Hu; Kai Huang; Kun Ding; et al. (Environmental Science and Pollution Research, 2022)

Grain size-dependent geochemical evidence reveals provenance and implications of aeolian sands, Dinggye region, southern Tibet - You-gui Chen; Mei-hui Pan; Ze-wen Hao; Yu-han Qi; Chen-lu Li (Journal of Mountain Science, 2022)

Structure and maintenance mechanisms of the Mascarene High in austral winter - Yuan Zhao; Zhiping Wen; Xiuzhen Li; Ruidan Chen; Guixing Chen (International Journal of Climatology, 2022)
The Mascarene High (MH), is a key component of the Asian‐Africa‐Australia monsoon system in austral winter (JJA), spanning over the South Indian Ocean (15°–35°S, 15°–110°E). Its three‐dimensional structures and maintenance mechanisms are examined in this study. It is a low‐level subtropical high dominating the southern Africa and South Indian Ocean, characterized by a north‐westward tilt with height, which is attributed to its spatially inhomogeneous thermal structure. Large‐scale subsidence characterizes the main body of the MH, with the stronger subsidence to the east than to the west. Diagnosis using the complete form of the vertical vorticity tendency equation shows that the anticyclonic structure of the MH, which can be described by the distribution of meridional wind, is maintained mainly by the vertical gradient of diabatic heating, change in static stability, and friction dissipation. In particular, a combination of sensible heating and longwave radiative cooling results in a vertical decreasing gradient of diabatic heating in the lower troposphere. It generates the stronger southerlies over the subtropical South Indian Ocean than over the southern Africa. Meanwhile, over the South Indian Ocean, the increasing static stability as a result of the downward transport of a more stable atmosphere partly offsets the effect of the vertical gradient of diabatic heating, and southerlies still prevail there. Over the southern Africa, topographic friction dissipation induces northerlies, balancing the effect of the vertical gradient of diabatic heating with a stronger magnitude, and northerlies prevail.

Diversity and Structure of Demersal Fish Community Over the Northern Slope in the South China Sea - Jun Zhang; Kui Zhang; Yan-e Jiang; Yuan-jie Li; Jiang-tao Fan; Wen-ming Yu; Zuo-zhi Chen (Frontiers in Marine Science, 2022)
Three bottom trawl surveys over the northern continental slope in the South China Sea (18°50′–20°40′N, 112°50′–115°10′E) were carried out, in June 2015, March 2017 and September 2018, to investigate species composition, biodiversity and community structure of demersal fish. Surveys in 2015, 2017 and 2018 captured 97 fish species (representing 77 genera, 52 families, 26 orders), 108 fish species (representing 84 genera, 61 families, 19 orders) and 126 fish species (representing 105 genera, 74 families, 25 orders), respectively. Three surveys captured a total of 252 fish species, representing 164 genera, 97 families, 30 orders. Perciformes dominated. Species richness in station linking shallow continental shelf with deep slope was the lowest among stations. In three surveys, 16 species occurred in the catches of three surveys, accounting for 6.35% of all species. Species replacement rate between stations showed a significant linear relationship with the depth difference and latitude difference. Margalef’s species richness index ( D ), Shannon–Weiner diversity index ( H’ ) and Pielou’s evenness index ( J’ ) among stations ranged 2.65–6.74, 1.02–4.15 and 0.28–1.14, respectively. Differences of D , H ’ and J ’ were insignificant among seasons. There were significant positive linear relations between H’ and J’ and latitude. D , H’ and J’ decreased with increasing sampling depth, however the relations were not significant. Based on multivariate statistical analysis, fish community at species level was divided into five groups with average dissimilarities of 95.69%–99.96%. In terms of genus and family, average dissimilarities among groups were more than 88.11% and 82.69%. There were significant differences in species composition between depths, but no significant differences between seasons and temperatures, as well as in genus and family composition.

Study on the resource utilization of high fluorine-containing organic waste through fluidized incineration - Wenhan Li; Zengyi Ma; Jianhua Yan; Qianming Huang; Xingjian Wen; Zian Zhai; Bochen Huang; Shuang Wang; Yongqiang Chen (Waste Disposal & Sustainable Energy, 2022)

Pyrimethamine inhibits cell growth by inducing cell senescence and boosting CD8+ T-cell mediated cytotoxicity in colorectal cancer - Haiyan Dong; Limei Hu; Weiqian Li; Mengchen Shi; Lingyuan He; Chen Wang; Yijia Hu; Huihui Wang; Chuangyu Wen; Huanliang Liu; Xiangling Yang (Molecular Biology Reports, 2022)
Background The emergence of nonresponse or resistance to traditional chemotherapeutic agents is one of the main challenges of colorectal cancer (CRC) therapies. Thus, novel therapeutic drugs that can improve the clinical outcomes of CRC patients are urgently needed. The purpose of this study was to investigate the effects and mechanisms of pyrimethamine in CRC. Methods and results In this study, we assessed the role of pyrimethamine on CRC cell growth by cell counting kit-8 and colony formation assays. Cell cycle distribution and cellular senescence were determined by flow cytometry and senescence-associated β-galactosidase staining respectively. RNA-seq analysis and western blotting were used to investigate the potential pathways of pyrimethamine in CRC development. Moreover, animal experiments were performed to evaluate the effect of pyrimethamine in vivo. Our results demonstrated that pyrimethamine could inhibit cell growth by inducing S phase arrest followed by cellular senescence in CRC cells, and the p38MAPK-p53 axis was probably involved in that effect. In addition, pyrimethamine could also boost CD8 + T-cell mediated cytotoxicity and exert antitumor activity in vivo. Conclusion These results indicated that pyrimethamine may be a promising candidate agent for CRC treatment.

Hybrid molecules of scutellarein and 3, 5, 6-trimethylpyrazine-2-formic acid linked with polar amino acid for ischemic stroke - Shuxia Wu; Mingji Liu; Jinlan Wen; Lina Chen; Jun Lu; Lei Li; Yaxin Yang; Yongxi Dong; Li Dong; Yongxi Dong (Medicinal Chemistry Research, 2022)

Dynamic changes of reactive oxygen species in paddy overlying water: mechanisms and implications - Shaochong Liu; Mengxi Tan; Danyu Huang; Dixiang Wang; Mengyuan Geng; Jialin Wen; Changyin Zhu; Liqiang Ge; Ning Chen; Yan Gao; Jiangye Li; Jianbin Pan; et al. (Journal of Soils and Sediments, 2022)

Whole-Transcriptome Analysis of Serum L1CAM-Captured Extracellular Vesicles Reveals Neural and Glycosylation Changes in Autism Spectrum Disorder - Yannan Qin; Li Cao; Jinyuan Zhang; Haiqing Zhang; Shuang Cai; Bo Guo; Fei Wu; Lingyu Zhao; Wen Li; Lei Ni; Liying Liu; Xiaofei Wang; et al. (Journal of Molecular Neuroscience, 2022)

Novel insights for PI3KC3 in mediating lipid accumulation in yellow catfish Pelteobagrus fulvidraco - Mei-Qin Zhuo; Jun Chen; Mei-Li Wu; Wen-Biao Wang (Fish Physiology and Biochemistry, 2022)

Pulmonary Infection Caused by Strongyloides stercoralis - Lingqing Xu; Qianjun He; Linjuan Chen; Jiaxi Lv; Yinxian Tang; Yuzhen Li; Zhongwen Zhang; Weihong Wen; Guoquan Zhong; Hui Liu; Bishi Fu (Acta Parasitologica, 2022)

The Characteristics and Expression Profile of Peptidoglycan Recognition Protein 2 in the Accessory Nidamental Gland of the Bigfin Reef Squid During Bacterial Colonization - Hau-Wen Li; Wei-Lun Kuo; Chi Chen; Yung-Che Tseng; Ching-Fong Chang; Guan-Chung Wu (Frontiers in Marine Science, 2022)
Some cephalopods carry microorganisms in two specialized organs, the light organ and the accessory nidamental gland (ANG). For the light organ, comprehensive mechanisms have been described for winnowing (bacterial selection) and maintenance of the symbiotic luminescent bacterium Vibrio fischeri ( V. fischeri ). However, the mechanisms controlling bacterial selection and maintenance during bacterial colonization of the ANG are open biological issues with physiological significance. Our recent study on bigfin reef squid ( Sepioteuthis lessoniana ) already showed that the ANG bacterial community shifts gradually and exhibits decreased diversity throughout maturation. This study further describes a potential role of an innate immunity-involved molecule, peptidoglycan recognition proteins (PGRPs), in the ANG of bigfin reef squid during bacterial transmission and colonization. First, we found that four homologs of the PGRP family are expressed in the ANG of bigfin reef squid ( sl PGRP2-5), but only slPgrp2 transcript levels are highly correlated with ANG development and bacterial colonization. Besides, slPgrp2 transcripts are mainly expressed in the epithelial cells of certain secondary tubules of ANG, and the expression levels are varied in the epithelial cells of other secondary tubules. This data reveals that slPgrp2 transcripts may associate with the composition of bacterial consortium and its secretary factors. Moreover, recombinant sl PGRP2 had a negative effect of Escherichia coli ( E.coli ) which inhibited bacterial growth in culture. Therefore, our data suggest slPgrp2 expression in the epithelial cells of secondary tubules in the ANG may have an essential role in the winnowing and maintenance of holobiont homeostasis in bigfin reef squid.

Monascuslactams A–D, cytotoxic γ-lactams from marine fungus Monascus albidus BB3 - Qi Guo; Xiao-Ming Dai; Wen-Jian Lan; Liu-Ping Chen; Chi-Keung Lam; Gong-Kan Feng; Rong Deng; Xiao-Feng Zhu; Hou-Jin Li (Natural Product Research, 2022)

A new highly oxygenated germacranolide from Carpesium nepalense var. lanatum (C.B.Clarke) Kitam - Yi-Fan Yu; Yue-Qian Li; Ru-Yue Wang; Xu Liu; Wen-Bo Cui; Xiao-Han Chen; Cheng-Mu Zhao; Feng-Ming Qi; Zhan-Xin Zhang; Dong-Qing Fei (Natural Product Research, 2022)

Phenolic compounds from the sclerotia of Inonotus obliquus - Yan-Mei Wei; Li Yang; Wen-Li Mei; Hui-Qin Chen; Cai-Hong Cai; Wei Li; Wen-Hua Dong; Zhi-Bao Chen; Hao-Fu Dai (Natural Product Research, 2022)

Exogenous artificial DNA forms chromatin structure with active transcription in yeast - Jianting Zhou; Chao Zhang; Ran Wei; Mingzhe Han; Songduo Wang; Kaiguang Yang; Lihua Zhang; Weigang Chen; Mingzhang Wen; Cheng Li; Wei Tao; Ying-Jin Yuan (Science China Life Sciences, 2022)
Yeast artificial chromosomes (YACs) are important tools for sequencing, gene cloning, and transferring large quantities of genetic information. However, the structure and activity of YAC chromatin, as well as the unintended impacts of introducing foreign DNA sequences on DNA-associated biochemical events, have not been widely explored. Here, we showed that abundant genetic elements like TATA box and transcription factor-binding motifs occurred unintentionally in a previously reported data-carrying chromosome (dChr). In addition, we used state-of-the-art sequencing technologies to comprehensively profile the genetic, epigenetic, transcriptional, and proteomic characteristics of the exogenous dChr. We found that the data-carrying DNA formed active chromatin with high chromatin accessibility and H3K4 tri-methylation levels. The dChr also displayed highly pervasive transcriptional ability and transcribed hundreds of noncoding RNAs. The results demonstrated that exogenous artificial chromosomes formed chromatin structures and did not remain as naked or loose plasmids. A better understanding of the YAC chromatin nature will improve our ability to design better data-storage chromosomes.

Erratum to: MYH7B variants cause hypertrophic cardiomyopathy by activating the CaMK-signaling pathway - Peng Chen; Zongzhe Li; Jiali Nie; Hong Wang; Bo Yu; Zheng Wen; Yang Sun; Xiaolu Shi; Li Jin; Dao-Wen Wang (Science China Life Sciences, 2022)

The Effects of Ground and Treadmill Running on Energy Metabolism and Muscle Contractile Properties: A Randomized Cross-Over Study - Yuan Zhou; Jian-gang Chen; Xiao-long Li; Xin-liang Pan; Yi-zheng Zhou; Zheng-ao Li; Zhi-cheng Liang; Jia-min Long; Ming-ze Qin; Jing Zhang; Bing Shi; Bing-jun Wan; et al. (Journal of Science in Sport and Exercise, 2022)
Purpose This study aimed to compare the effects of ground and treadmill running on energy metabolism and muscle contractile properties, providing a basis for the general public to choose running venues. Methods Ten male college students (age, 20.10 ± 1.53 years; height, 176.20 ± 5.49 cm; weight, 72.14 ± 8.25 kg; body fat percent, 12.41% ± 4.65%) were recruited in this study. Energy expenditure (EE) was measured using the accelerometer (GT9X) combined with specific estimation equations. Average heart rate (HR) was measured using a heart rate band (Polar). Muscle contractile properties were assessed by measuring muscle displacement (Dm) and contraction velocity (Vc) using tensiomyography (TMG-S1). Blood glucose (Glu) and lactate (Lac) were measured by portable devices (eB-G and Lactate Scout). The running speed was 9 km/h and the duration was 25 min. Two-way ANOVA (protocol × time) was used to analyze the effect of running protocols on energy metabolism and muscle contractile properties. Results EE of treadmill running was significantly higher than EE of ground running (protocol main effect, P < 0.001), and HR of treadmill running was significantly higher than that of ground running in the first testing time (protocol simple effect, P = 0.026; protocol × time interaction P = 0.043). The decrease in Dm of the rectus femoris after treadmill running was significantly higher than that of ground running (protocol main effect, P = 0.009). The interaction of different running protocols and testing times on Lac was significant ( P = 0.025), but all results of the simple effects analysis were not statistically significant ( P > 0.05). Conclusion Our study found a difference in energy expenditure between treadmill and ground running at 9 km/h with duration of 25 min. In addition, treadmills are more likely to cause a decrease in muscle displacement distance of the rectus femoris measured after exercise than ground running. Future studies are needed to further investigate whether the differences are induced by internal metabolism or the environmental conditions of running.

Identification of PDXDC1 as a novel pleiotropic susceptibility locus shared between lumbar spine bone mineral density and birth weight - Yu-Qian Song; Shi-Di Hu; Xu Lin; Xiang-He Meng; Xiao Wang; Yin-Hua Zhang; Cheng Peng; Rui Gong; Tao Xu; Tong Zhang; Chen-Zhong Li; Dao-Yan Pan; et al. (Journal of Molecular Medicine, 2022)
An increasing number of epidemiological studies have suggested that birth weight (BW) may be a determinant of bone health later in life, although the underlying genetic mechanism remains unclear. Here, we applied a pleiotropic conditional false discovery rate (cFDR) approach to the genome-wide association study (GWAS) summary statistics for lumbar spine bone mineral density (LS BMD) and BW, aiming to identify novel susceptibility variants shared between these two traits. We detected 5 novel potential pleiotropic loci which are located at or near 7 different genes ( NTAN1 , PDXDC1 , CACNA1G , JAG1 , FAT1P1 , CCDC170 , ESR1 ), among which PDXDC1 and FAT1P1 have not previously been linked to these phenotypes. To partially validate the findings, we demonstrated that the expression of PDXDC1 was dramatically reduced in ovariectomized (OVX) mice in comparison with sham-operated (SHAM) mice in both the growth plate and trabecula bone. Furthermore, immunohistochemistry assay with serial sections showed that both osteoclasts and osteoblasts express PDXDC1 , supporting its potential role in bone metabolism. In conclusion, our study provides insights into some shared genetic mechanisms for BMD and BW as well as a novel potential therapeutic target for the prevention of OP in the early stages of the disease development. Key messages We investigated pleiotropy-informed enrichment between LS BMD and BW. We identified genetic variants related to both LS BMD and BW by utilizing a cFDR approach. PDXDC1 is a novel pleiotropic gene which may be related to both LS BMD and BW. Elevated expression of PDXDC1 is related to higher BMD and lower ratio n-6/n-3 PUFA indicating a bone protective effect of PDXDC1.

Differences of carbon and nitrogen stoichiometry between different habitats in two natural Korean pine forests in Northeast China’s mountainous areas - Ya-fei Wang; Wen-biao Duan; Mei-xue Qu; Li-xin Chen; Hang-yu Lan; Xi-feng Yang; Si-jing Meng; Jia Chen (Journal of Mountain Science, 2022)

Neobacillus rhizophilus sp. nov. and Neobacillus citreus sp. nov., isolated from the citrus rhizosphere soil - Guo-Hong Liu; Manik Prabhu Narsing Rao; Qian-Qian Chen; Huai Shi; Jian-Mei Che; Bo Liu; Wen-Jun Li (Archives of Microbiology, 2022)

A new picrotoxane-type sesquiterpene from Dendrobium nobile Lindl - Pei Wang; Xin Chen; Cai-Hong Cai; Fan-Dong Kong; Sheng-Zhuo Huang; Jing-Zhe Yuan; Xing-Lian Xu; Wen-Li Mei; Hao-Fu Dai (Natural Product Research, 2022)

Numerical simulation of non-cohesive homogeneous dam breaching due to overtopping considering the seepage effect - Yanlong Li; Anke Chen; Lifeng Wen; Peng Bu; Kangping Li (European Journal of Environmental and Civil Engineering, 2022)

Gene editing and its applications in biomedicine - Guanglei Li; Xiangyang Li; Songkuan Zhuang; Liren Wang; Yifan Zhu; Yangcan Chen; Wen Sun; Zeguang Wu; Zhuo Zhou; Jia Chen; Xingxu Huang; Jin Wang; et al. (Science China Life Sciences, 2022)

HaCYC2c regulating the heteromorphous development and functional differentiation of florets by recognizing HaNDUA2 in sunflower - Zhuoyuan He; Wenjing Zeng; Weiying Chen; Yichao Wu; Guoqin Wen; Xitong Chen; Qian Wang; Jiayan Zhou; Yunxiang Li; Zaijun Yang; Jian Zou; Jun Yang (Plant Cell Reports, 2022)

Measurement of atmospheric conductivity on the Qinghai-Tibet Plateau in China - Lei Li; Jianfeng Su; Tao Chen; Shuo Ti; Han Wu; Jing Luo; Wen Li; Renkang Li (Meteorology and Atmospheric Physics, 2022)

Complete Depletion of Primordial Germ Cells Results in Masculinization of Monopterus albus, a Protogynous Hermaphroditic Fish - Mingxi Hou; Ke Feng; Hongrui Luo; Yinjun Jiang; Wen Xu; Yongming Li; Yanlong Song; Ji Chen; Binbin Tao; Zuoyan Zhu; Wei Hu (Marine Biotechnology, 2022)

Dihydroartemisinin ameliorates chronic nonbacterial prostatitis and epithelial cellular inflammation by blocking the E2F7/HIF1α pathway - Yan Zhou; Jun-hao Wang; Jian-peng Han; Jian-yong Feng; Kuo Guo; Fei Du; Wen-bin Chen; Yong-zhang Li (Inflammation Research, 2022)

Cavin-1 promotes M2 macrophages/microglia polarization via SOCS3 - Wei Huang; Yiyi Hong; Wenjing He; Li Jiang; Wen Deng; Biyan Peng; Fen Tang; Chaolan Shen; Qianqian Lan; Hui Huang; Haibin Zhong; Jian Lv; et al. (Inflammation Research, 2022)

Genetic diversity and population structure of Curcuma alismatifolia Gagnep. accessions revealed by SSR markers - Hui-Wen Yu; Ling-Jun Ke; Yi-Lan Xiao; Si-Jia Chen; Yuan-Yuan Li; Qi-Lin Tian; Yun-He Li; Jin-Shui Lin; Luan-Mei Lu (Genetic Resources and Crop Evolution, 2022)

Correction to: Lederbergia citri sp. nov., and Lederbergia citrisecundus sp. nov., isolated from citrus rhizosphere - Guo‑Hong Liu; Manik Prabhu Narsing Rao; Qian‑Qian Chen; Jian‑Mei Che; Huai Shi; Bo Liu; Wen‑Jun Li (Current Microbiology, 2022)

Correction to: Spindle‑related brain activation in patients with insomnia disorder: An EEG‑fMRI study - Yan Shao; Guangyuan Zou; Serik Tabarak; Jie Chen; Xuejiao Gao; Ping Yao; Jiayi Liu; Yuezhen Li; Nana Xiong; Wen Pan; Mengying Ma; Shuqin Zhou; et al. (Brain Imaging and Behavior, 2022)

Spindle-related brain activation in patients with insomnia disorder: An EEG-fMRI study - Yan Shao; Guangyuan Zou; Serik Tabarak; Jie Chen; Xuejiao Gao; Ping Yao; Jiayi Liu; Yuezhen Li; Nana Xiong; Wen Pan; Mengying Ma; Shuqin Zhou; et al. (Brain Imaging and Behavior, 2022)

Characteristics of the BDS-3 multipath effect and mitigation methods using precise point positioning - Ran Lu; Wen Chen; Chenglong Zhang; Lei Li; Yu Peng; Zhengqi Zheng (GPS Solutions, 2022)

Spatial distribution patterns and sources for potential toxic elements in soil in the Daxing District, Beijing, China - Yong-long An; Yong Huang; Zhi-qiang Yin; Xiu-lan Yin; Xia Li; Li-qin Wan; Ai-fang Jin; Wen-juan Li; Hai Shao; Li-li Chen (Arabian Journal of Geosciences, 2022)

Alkaloids constituents from the roots of Phragmites australis (Cav.) Trin. ex Steud. with their cytotoxic activities - Ying Chen; Li Li; Li-Rui Jiang; Jia-Yin Tan; Li-Na Guo; Xiao-Li Wang; Wei Dong; Wen-Bao Wang; Ji-Kai Sun; Bo Song (Natural Product Research, 2022)

Genome-wide analysis of the Glutathione S-Transferase family in wild Medicago ruthenica and drought-tolerant breeding application of MruGSTU39 gene in cultivated alfalfa - Tianzuo Wang; Di Zhang; Li Chen; Jing Wang; Wen-Hao Zhang (Theoretical and Applied Genetics, 2022)

Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated Encephalopathy by Promoting Ferroptosis Through Regulating miR-9-5p/TFRC and GOT1 Axis - Xue-biao Wei; Wen-qiang Jiang; Ju-hao Zeng; Lin-qiang Huang; Hong-guang Ding; Yuan-wen Jing; Yong-li Han; Yi-chen Li; Sheng-long Chen (Molecular Neurobiology, 2022)
Sepsis can cause sepsis-associated encephalopathy (SAE), but whether SAE was induced or exacerbated by ferroptosis remains unknown. In this study, the rat sepsis model was constructed using the cecal ligation and puncture method. The blood–brain barrier (BBB) permeability was measured by Evans blue dye (EBD) in vivo. The levels of ROS, Fe ion, MDA, GSH, and GPX4 were assessed by enzyme-linked immunosorbent assay (ELISA). The exosomes isolated from serum were cultured with bEnd.3 cells for the in vitro analysis. Moreover, bEnd.3 cells cultured with 100 μM FeCl3 (iron-rich) were to simulate ferroptosis stress. The cell viability was evaluated by Cell Counting Kit-8 (CCK-8) assay. A dual-luciferase reporter gene assay was performed to confirm the relationship between miR-9-5p with NEAT1, TFRC , and GOT1 . In vivo, it is found that BBB permeability was damaged in model rats. Level of ROS, Fe ion, and MDA was increased, and level of GSH and GPX4 was decreased, which means ferroptosis was induced by sepsis. Exosome-packaged NEAT1 in serum was significantly upregulated in model rats. In vitro, it is found that NEAT1 functions as a ceRNA for miR-9-5p to facilitate TFRC and GOT1 expression. Overexpression of NEAT1 enhanced ferroptosis stress in bEnd.3 cells. Increased miR-9-5p alleviated sepsis-induced ferroptosis by suppressing the expression of TFRC and GOT1 both in vivo and in vitro. In conclusion, these findings suggest that sepsis induced high expression of serous exosome-derived NEAT1, and it might exacerbate SAE by promoting ferroptosis through regulating miR-9-5p/ TFRC and GOT1 axis.

Activation of multiple proteolysis systems contributes to acute cadmium cytotoxicity - Yen-Hsiu Yeh; Chia-Chih Tsai; Tien-Wen Chen; Chieh-Hua Lee; Wei-Jer Chang; Mei-Yi Hsieh; Tsai-Kun Li (Molecular and Cellular Biochemistry, 2022)

In situ application of the diffusive gradients in thin film technique in aquaculture ponds for monitoring antibiotics, hormones, and herbicides - Yiqin Chen; Ju Wen; Meng Wu; Juan-Ying Li; Qian Wang; Jie Yin (Environmental Science and Pollution Research, 2022)

Photocatalytic degradation of imidacloprid by optimized Bi2WO6/NH2-MIL-88B(Fe) composite under visible light - Mao-Long Chen; Tian-Hui Lu; Shan-Shan Li; Li Wen; Zhou Xu; Yun-Hui Cheng (Environmental Science and Pollution Research, 2022)

Estimation of Avian Influenza Viruses in Water Environments of Live Poultry Markets in Changsha, China, 2014 to 2018 - Xiaoyu Li; Rusheng Zhang; Zheng Huang; Dong Yao; Lei Luo; Jingfang Chen; Wen Ye; Lingzhi Li; Shan Xiao; Xiaolei Liu; Xinhua Ou; Biancheng Sun; et al. (Food and Environmental Virology, 2022)

Genetic Diversity and Structure of Tropical Porites lutea Populations Highlight Their High Adaptive Potential to Environmental Changes in the South China Sea - Yanqiu Luo; Wen Huang; Kefu Yu; Ming Li; Biao Chen; Xueyong Huang; Zhenjun Qin (Frontiers in Marine Science, 2022)
Global climate change and anthropogenic disturbance have significantly degraded biodiversity in coral reef ecosystems. The genetic potential and adaptability of corals are key factors used to predict the fate of global coral reefs under climate change. In this study, we used eight microsatellite loci to study the patterns of reproduction, genetic diversity, and genetic structure of 302 Porites lutea samples across 13° latitudes in the South China Sea (8.8644°N–22.6117°N). The results indicated that P. lutea reproduces largely via sexual reproduction on scales of 5 m and greater and has abundant gene diversity. Additionally, the tropical populations harbored high genetic diversity (based on alleles, effective number of alleles, gene diversity, and heterozygosity). In contrast, genetic diversity was lower in subtropical coral populations. Genetic variation values and pairwise F ST revealed that tropical and subtropical populations had significantly different genetic structures. Finally, the Mantel tests showed that the genetic differentiation and genetic variation of P. lutea were strongly correlated with sea surface temperature and slightly correlated with geographical distance. These results indicated that tropical P. lutea populations have high genetic potential and adaptability because of their sexual reproduction and genetic diversity, giving them a greater capacity to cope with climate change. Subtropical coral populations showed lower genetic diversity and, thus, relatively poor genetic resilience in response to low average sea surface temperature and human activities. Our study provides a theoretical basis for the protection and restoration of coral reefs.

Four new prenylflavonol glycosides from the leaves of Cyclocarya paliurus - Zi-Jun Ye; Hui-Hui Sun; Zu-Hui Chen; Jian-Ping Wu; Jing Li; Hui Zhu; Lu-Lu Huang; Xi-Wen Chang; Sai-Yu Ou; Wen-Xuan Wang; Xiao-Ai He; Gang-Zhi Zhu; et al. (Natural Product Research, 2022)

Cancer metabolism and tumor microenvironment: fostering each other? - Yiyuan Yuan; Huimin Li; Wang Pu; Leilei Chen; Dong Guo; Hongfei Jiang; Bo He; Siyuan Qin; Kui Wang; Na Li; Jingwei Feng; Jing Wen; et al. (Science China Life Sciences, 2022)

Litter nitrogen concentration changes mediate effects of drought and plant species richness on litter decomposition - Jiang Wang; Yuan Ge; Johannes H. C. Cornelissen; Xiao-Yan Wang; Song Gao; Yi Bai; Tong Chen; Zhong-Wang Jing; Chong-Bang Zhang; Wen-Li Liu; Jun-Min Li; Fei-Hai Yu (Oecologia, 2022)

Publisher Correction to: Compression Sleeve Changes Corticomuscular Connectivity and Sensorimotor Function - Wen‑Wen Yang; Li‑Ling Hope Pan; Chen‑Sheng Chen; Shun‑Hwa Wei; Chiang Liu; Li‑Wei Chou (Journal of Medical and Biological Engineering, 2022)

Dissolving microneedle rollers for rapid transdermal drug delivery - Xiao Peng Zhang; Bao Li Zhang; Bo Zhi Chen; Ze Qiang Zhao; Wen Min Fei; Yong Cui; Xin Dong Guo (Drug Delivery and Translational Research, 2022)

Lederbergia citri sp. nov., and Lederbergia citrisecundus sp. nov., isolated from citrus rhizosphere - Guo-Hong Liu; Manik Prabhu Narsing Rao; Qian-Qian Chen; Jian-Mei Che; Huai Shi; Bo Liu; Wen-Jun Li (Current Microbiology, 2022)

Tracing the Origins of Blueberries by Their Mineral Element Contents and 87Sr/86Sr Ratios - Qihang Li; Chaofeng Li; Shengyang Xiao; Heng Wang; Cheng Chen; Xiao Wei; Xuefeng Wen (Biological Trace Element Research, 2022)

Evaluation of suitable qRT-PCR normalization genes for various citrus rootstocks - Wen He; Rui Xie; Huan Li; Yan Wang; Qing Chen; Yuanxiu Lin; Yunting Zhang; Ya Luo; Yong Zhang; Haoru Tang; Xiaorong Wang (Plant Biotechnology Reports, 2022)

East Asian summer monsoon changes in subtropical China since late Pleistocene: Evidence from the Ailuropoda-Stegodon fauna - Zhi-wen Li; Li Sun; Bao-sheng Li; Feng-nian Wang; Ding-ding Du; You-gui Song; Hui-Juan Zhang; Liu-qin Chen; Dan Xu (Journal of Mountain Science, 2022)

Complete genome sequence of a novel mitovirus detected in Paris polyphylla var. yunnanensis - Zeli Chen; Lu Chen; Rex Frimpong Anane; Zhe Wang; Like Gao; Shangyun Li; Guosong Wen; Daihong Yu; Mingfu Zhao (Archives of Virology, 2022)

The impact of different rotation regime on the soil bacterial and fungal communities in an intensively managed agricultural region - Jie Lu; Wenxin Li; Yuhao Yang; Fan Ye; Huayu Lu; Xiangyang Chen; Fu Chen; Xinya Wen (Archives of Microbiology, 2022)

Indicator species drive the key ecological functions of microbiota in a river impacted by acid mine drainage generated by rare earth elements mining in South China - Ziwu Chen; Xi Zhong; Mengyuan Zheng; Wen‐Shen Liu; Yingheng Fei; Kengbo Ding; Yaying Li; Ye Liu; Yuanqing Chao; Ye‐Tao Tang; Shizhong Wang; Rongliang Qiu (Environmental Microbiology, 2022)
Summary Acid mine drainage (AMD) generated by rare earth elements (REEs) deposits exploration contains high concentrations of REEs, ammonium and sulfates, which is quite different from typical metallic AMD. Currently, microbial responses and ecological functions in REEs‐AMD impacted rivers are unknown. Here, 16S rRNA analysis and genome‐resolved metagenomics were performed on microbial community collected from a REEs‐AMD contaminated river. The results showed that REEs‐AMD significantly changed river microbial diversity and shaped unique indicator species (e.g. Thaumarchaeota , Methylophilales , Rhodospirillales and Burkholderiales ). The main environmental factors regulating community were pH, ammonium and REEs, among which high concentration of REEs increased REEs‐dependent enzyme‐encoding genes ( XoxF and ExaF / PedH ). Additionally, we reconstructed 566 metagenome‐assembled genomes covering 70.4% of identifying indicators. Genome‐centric analysis revealed that the abundant archaea Thaumarchaeota and Xanthomonadaceae were often involved in nitrification and denitrification, while family Burkholderiaceae were capable of sulfide oxidation coupled with dissimilatory nitrate reduction to ammonium. These indicators play crucial roles in nitrogen and sulfur cycling as well as REEs immobilization in REEs‐AMD contaminated rivers. This study confirmed the potential dual effect of REEs on microbial community at the functional gene level. Our investigation on the ecological roles of indicators further provided new insights for the development of REEs‐AMD bioremediation.

Joint Inversion and Application of DC and Full-Domain TEM with Particle Swarm Optimization - Yi Dong; Jiulong Cheng; Haijun Xie; Fei Li; Junjie Xue; Laifu Wen; Zhi Chen; Junjun Jiao (Pure and Applied Geophysics, 2022)

Near-epicenter weather conditions several hours before strong earthquakes (Ms ≥ 6) - Tao Chen; Lei Li; Xiao-Xin Zhang; Qi-Ming Ma; Wen Li; Shuo Ti; Han Wu; Ren-Kang Li; Jing Luo; Jian-Feng Su (Natural Hazards, 2022)

HMGB1-RAGE Pathway Contributes to the Abnormal Migration of Endogenous Subventricular Zone Neural Progenitors in an Experimental Model of Focal Microgyria - Yi-Wen Mei; Tian-Lan Huang; Xin Chen; Si-Xun Yu; Jie Li; Zhi Zhang; Yang He; Da-qing Guo; Hai-Feng Shu (Journal of Molecular Neuroscience, 2022)

Hydrochemical environment of a fractured karst aquifer influenced by petroleum hydrocarbons - Yuming Peng; Yongli Guo; Qing Wu; Huanliang Chen; Chao Ma; Chuanlei Li; Wen Liu (Environmental Science and Pollution Research, 2022)

Study on metal binding capacity of the freshwater crab Sinopotamon henanense’s recombinant copper specific binding metallothionein expressed in Escherichia coli - Lu Wang; Hui Zhen Yang; Wen Li Ma; Chien Min Chen; Lan Wang (Ecotoxicology, 2022)

Using computational fluid dynamic simulation with Flow-3D to reveal the origin of the mushroom stone in the Xiqiao Mountain of Guangdong, China - Jian-cheng Li; Wei Wang; Yan-ming Zheng; Xiao-hao Wen; Jing Feng; Li Sheng; Chen Wang; Ming-kun Qiu (Journal of Mountain Science, 2022)

Characterization and Cys-directed mutagenesis of urate oxidase from Bacillus subtilis BS04 - Tong-tong Zhu; Hong-na Chen; Lei Yang; Ying-bao Liu; Wei Li; Wen-xiu Sun (Biologia, 2022)

Mitogenomes provide new insights into the evolutionary history of Prodiamesinae (Diptera: Chironomidae) - Xiao‐Long Lin; Yan‐Min Zhao; Li‐Ping Yan; Wen‐Bin Liu; Wen‐Jun Bu; Xin‐Hua Wang; Chen‐Guang Zheng (Zoologica Scripta, 2022)
Evolutionary analysis of Prodiamesinae has long been impeded by lack of information, and its phylogenetic relationship with Orthocladiinae remains questionable. Here, ten complete mitochondrial genomes (mitogenomes) of Orthocladiinae sensu lato were newly sequenced, including three Prodiamesinae species and seven Orthocladiinae species. Coupled with published mitogenomes, a total of 12 mitogenomes of Orthocladiinae sensu lato were selected for a comparative mitogenomic analysis and phylogenetic reconstruction. Mitogenomes of Orthocladiinae sensu lato are conserved in structure, and all genes arrange the same gene order as the ancestral insect mitogenome. Nucleotide composition is highly biased, and the control region displayed the highest A + T content. All protein‐coding genes are under purifying selection, and the ATP8 evolves at the fastest rate. In addition, the mitogenomes of Orthocladiinae sensu lato are highly conserved, and they are practically useful for phylogenetic inference, suggesting a re‐classification of Orthocladiinae by sinking Prodiamesinae as a subgroup of Orthocladiinae.

Not out of the woods yet: Signatures of the prolonged negative genetic consequences of a population bottleneck in a rapidly re‐expanding wader, the black‐faced spoonbill Platalea minor - Shou‐Hsien Li; Yang Liu; Chia‐Fen Yeh; Yuchen Fu; Carol K. L. Yeung; Chun‐Cheng Lee; Chi‐Cheng Chiu; Tung Hui Kuo; Fang‐Tse Chan; Yu‐Chia Chen; Wen‐Ya Ko; Cheng‐Te Yao (Molecular Ecology, 2022)
The long‐term persistence of a population which has suffered a bottleneck partly depends on how historical demographic dynamics impacted its genetic diversity and the accumulation of deleterious mutations. Here we provide genomic evidence for the genetic effect of a recent population bottleneck in the endangered black‐faced spoonbill ( Platalea minor ) after its rapid population recovery. Our data suggest that the bird's effective population size, N e , had been relatively stable (7500–9000) since 22,000 years ago; however, a recent brief yet severe bottleneck ( N e = 20) which we here estimated to occur around the 1940s wiped out >99% of its historical N e in roughly three generations. Despite a >15‐fold population recovery since 1988, we found that black‐faced spoonbill population has higher levels of inbreeding (7.4 times more runs of homozygosity) than its sister species, the royal spoonbill ( P. regia ), which is not thought to have undergone a marked population contraction. Although the two spoonbills have similar levels of genome‐wide genetic diversity, our results suggest that selection on more genes was relaxed in the black‐faced spoonbill; moreover individual black‐faced spoonbills carry more putatively deleterious mutations (Grantham's score > 50), and may therefore express more deleterious phenotypic effects than royal spoonbills. Here we demonstrate the value of using genomic indices to monitor levels of genetic erosion, inbreeding and mutation load in species with conservation concerns. To mitigate the prolonged negative genetic effect of a population bottleneck, we recommend that all possible measures should be employed to maintain population growth of a threatened species.

Numerical Simulation of the Physical–Chemical–Thermal Processes During Hydration Reaction of the Calcium Oxide/Calcium Hydroxide System in an Indirect Reactor - Mengyi Wang; Li Chen; Yuhao Zhou; Wen-Quan Tao (Transport in Porous Media, 2021)

Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish - Jiakui Chen; Gaofei Li; Junwei Lian; Ning Ma; Zhibin Huang; Jianchao Li; Zilong Wen; Wenqing Zhang; Yiyue Zhang (Science China Life Sciences, 2021)

Groundwater and root trait diversity jointly drive plant fine root biomass across arid inland river basin - Yin Wang; Jian-Ming Wang; Huan Yang; Guan-Jun Li; Chen Chen; Jing-Wen Li (Plant and Soil, 2021)

Whole Genomic DNA Methylation Profiling of CpG Sites in Promoter Regions of Dorsal Root Ganglion in Diabetic Neuropathic Pain Mice - Wen Chen; Ting Lan; Qingyu Sun; Yurui Zhang; Danmin Shen; Tingting Hu; Jing Liu; Yingzi Chong; Peipei Wang; Qian Li; Weihua Cui; Fei Yang (Journal of Molecular Neuroscience, 2021)

Interdecadal change in the relationship between boreal winter North Pacific Oscillation and Eastern Australian rainfall in the following autumn - Linye Song; Shangfeng Chen; Wen Chen; Wansuo Duan; Yun Li (Climate Dynamics, 2021)

Effects of Climate Variability on Habitat Range and Distribution of Chub Mackerel in the East China Sea - Wei Yu; Jian Wen; Xinjun Chen; Gang Li; Yuesong Li; Zhong Zhang (Journal of Ocean University of China, 2021)

Uncertainty of central China summer precipitation and related natural internal variability under global warming of 1 to 3°C - Zhibo Li; Wen Chen; Shangfeng Chen; Ying Sun; Danlei Qian (International Journal of Climatology, 2021)
This study examines the response of summer precipitation over central China to global warming via the 50‐member large‐ensemble simulations conducted with the Canadian Earth System Model Version 2. It is found that the model ensemble mean summer precipitation stagnates under warming of 1 to 3°C, while precipitation increases rapidly over central China after 3°C of warming. This phenomenon indicates a strong nonlinear relationship between precipitation change and global warming, and the effects due to natural internal variability are more substantial than those of CO 2 forcing in the early warming stage. We further examine the factors responsible for the large uncertainty of the precipitation projection over central China under warming of 1 to 3°C. For the members producing a precipitation increase over central China, the geopotential height and sea level pressure changes show a positive North Atlantic Oscillation–like trend pattern over the North Atlantic and a southeastward propagating atmospheric teleconnection from the North Atlantic to China. The atmospheric teleconnection from the mid–high‐latitude Atlantic to China provides diverging winds in the upper troposphere, causing ascending motion, and contributes to increased precipitation over central China. Besides, an El Niño‐like trend pattern of sea surface temperature (SST) is apparent in the preceding winter, which could contribute to the formation a low‐level anticyclone trend over the western North Pacific (WNP) in the subsequent summer via modulating the SST anomalies in the Indian and Atlantic oceans. The northward water vapour transport in the western part of the anticyclone also favours increased precipitation in central China. The above processes also apply to decreased precipitation, except with opposite signs of anomalies. This study highlights the combined contributions of mid–high‐latitude teleconnection and the WNP anticyclone related to tropical Pacific SST to the uncertainty in the projection of precipitation over central China.

Theoretical and Numerical Analysis of Blasting Pressure of Cylindrical Shells under Internal Explosive Loading - Zhan-Feng Chen; Hui-Jie Wang; Zhiqian Sang; Wen Wang; He Yang; Wei-Ming Meng; Yu-Xing Li (Journal of Marine Science and Engineering, 2021)
Cylindrical shells are principal structural elements that are used for many purposes, such as offshore, sub-marine, and airborne structures. The nonlinear mechanics model of internal blast loading was established to predict the dynamic blast pressure of cylindrical shells. However, due to the complexity of the nonlinear mechanical model, the solution process is time-consuming. In this study, the nonlinear mechanics model of internal blast loading is linearized, and the dynamic blast pressure of cylindrical shells is solved. First, a mechanical model of cylindrical shells subjected to internal blast loading is proposed. To simplify the calculation, the internal blast loading is reduced to linearly uniform variations. Second, according to the stress function method, the dynamic blast pressure equation of cylindrical shells subjected to blast loading is derived. Third, the calculated results are compared with those of the finite element method (FEM) under different durations of dynamic pressure pulse. Finally, to reduce the errors, the dynamic blast pressure equation is further optimized. The results demonstrate that the optimized equation is in good agreement with the FEM, and is feasible to linearize the internal blast loading of cylindrical shells.

Identification and antimicrobial properties of a new alkaloid produced by marine-derived Verrucosispora sp. FIM06-0036 - Ming-Hong Chen; Yun-Yang Lian; Dong-Sheng Fang; Li Chen; Jia Jia; Wen-Long Zhang; Ru Lin; Yang Xie; Hong-Kai Bi; Hong Jiang (Natural Product Research, 2021)

Cytotoxic triterpenoid glycosides from leaves of Cyclocarya paliurus - Hui-Hui Sun; Wen-Yan Lv; Jie Tan; Yu-Cheng Tang; Hui Zhu; Jian-Bo Qu; Jing Li; Jian-Ping Wu; Xi-Wen Chang; Zhi-Chun Yang; Wen-Xuan Wang; Zu-Hui Chen; et al. (Natural Product Research, 2021)

Three new dimeric 2-(2-phenylethyl)chromones from artificial agarwood of Aquilaria sinensis - Pan Xiang; Wen-Hua Dong; Cai-Hong Cai; Wei Li; Li-Man Zhou; Hao-Fu Dai; Hui-Qin Chen; Wen-Li Mei (Natural Product Research, 2021)

The co-expression of genes involved in seed coat and endosperm development promotes seed abortion in grapevine - Shasha Li; Xiangyu Geng; Shuo Chen; Keke Liu; Saisai Yu; Xiping Wang; Chaohong Zhang; Jianxia Zhang; Yingqiang Wen; Qiangwei Luo; Yan Xu; Yuejin Wang (Planta, 2021)

Evaluation of watershed soil erosion hazard using combination weight and GIS: a case study from eroded soil in Southern China - Shifa Chen; Wen Liu; Yonghui Bai; Xiaoying Luo; Hangfei Li; Xuan Zha (Natural Hazards, 2021)

Genomic characterization of a rare Carica papaya X chromosome mutant reveals a candidate monodehydroascorbate reductase 4 gene involved in all-hermaphrodite phenomenon - Jen-Ren Chen; Hiroki Ueno; Hideo Matsumura; Naoya Urasaki; Chen-Yu Lee; Fure-Chyi Chen; Shih-Wen Chin; Chun-Chi Liu; Chan-Tai Chiu; Kazuhiko Tarora; Jing-Yi Li; Chieh Ying Lee; et al. (Molecular Genetics and Genomics, 2021)

Transcriptomic responses of haloalkalitolerant bacterium Egicoccus halophilus EGI 80432T to highly alkaline stress - Dai-Di Chen; Manzoor Ahmad; Yong-Hong Liu; Shuang Wang; Bing-Bing Liu; Shu-Xian Guo; Hong-Chen Jiang; Wen-Sheng Shu; Wen-Jun Li (Extremophiles, 2021)

Phenotypic and genomic adaptations to the extremely high elevation in plateau zokor ( Myospalax baileyi ) - Tao Zhang; Jie Chen; Jia Zhang; Yuan‐Ting Guo; Xin Zhou; Meng‐Wen Li; Zhi‐Zhong Zheng; Tong‐Zuo Zhang; Robert W. Murphy; Eviatar Nevo; Peng Shi (Molecular Ecology, 2021)
The evolutionary outcomes of high elevation adaptation have been extensively described. However, whether widely distributed high elevation endemic animals adopt uniform mechanisms during adaptation to different elevational environments remains unknown, especially with respect to extreme high elevation environments. To explore this, we analysed the phenotypic and genomic data of seven populations of plateau zokor ( Myospalax baileyi ) along elevations ranging from 2,700 to 4,300 m. Based on whole‐genome sequencing data and demographic reconstruction of the evolutionary history, we show that two populations of plateau zokor living at elevations exceeding 3,700 m diverged from other populations nearly 10,000 years ago. Further, phenotypic comparisons reveal stress‐dependent adaptation, as two populations living at elevations exceeding 3,700 m have elevated ratios of heart mass to body mass relative to other populations, and the highest population (4,300 m) displays alterations in erythrocytes. Correspondingly, genomic analysis of selective sweeps indicates that positive selection might contribute to the observed phenotypic alterations in these two extremely high elevation populations, with the adaptive cardiovascular phenotypes of both populations possibly evolving under the functional constrains of their common ancestral population. Taken together, phenotypic and genomic evidence demonstrates that heterogeneous stressors impact adaptations to extreme elevations and reveals stress‐dependent and genetically constrained adaptation to hypoxia, collectively providing new insights into the high elevation adaptation.

A new ergostane derivative from the leaves of Heynea trijuga Roxburgh - Shou-Bai Liu; Zheng Cui; Hui-Qin Chen; Hao Wang; Wen-Hua Dong; Cai-Hong Cai; Wen-Li Mei; Hao-Fu Dai (Natural Product Research, 2021)

Two new cephalochromin derivative from the Alternaria sp. ZG22 - Xin-Ming Song; Xue-Ming Zhou; Ya-Ling Li; Li-Bing Huang; Cai-Cui Chen; Yan Gao; Lin He; Xiao-qun Mao; Bing Chen; Jing-Wen Liu; Hui-Jie Liu; Xiao-Ping Song; et al. (Natural Product Research, 2021)

Responses of leaf litter decomposability to nitrogen and phosphorus additions are associated with cell wall carbohydrate composition in a subtropical plantation - Xiang-Min Fang; Xiu-Lan Zhang; Ying-Ying Zong; Wen-Qing Li; Jian-Jun Li; Li-Ping Guo; Huimin Wang; Fu-Sheng Chen (Plant and Soil, 2021)

The feedback regulation of carbohydrates intake on food intake and appetite in grass carp (Ctenopharyngodon idella) - Xiao-Chen Yuan; Xu-Fang Liang; Ai-Xuan Li; Wen-Jing Cai (Fish Physiology and Biochemistry, 2021)

High-K calc-alkaline to shoshonitic intrusions in SE Tibet: implications for metasomatized lithospheric mantle beneath an active continental margin - Ren-Zhi Zhu; Ewa Słaby; Shao-Cong Lai; Li-Hui Chen; Jiangfeng Qin; Chao Zhang; Shaowei Zhao; Fangyi Zhang; Wen-hang Liu; Mike Fowler (Contributions to Mineralogy and Petrology, 2021)

An Investigation of Toxic Metal Levels (Pb, Cd, Cr, As, Hg) in Dried Porphyra and Laminaria Collected from Coastal Cities, China - Yan Chen; Yong-tao Liu; Fu-hua Wang; Dian Wen; Hui Yang; Xiao-li Zhao (Biological Trace Element Research, 2021)

Sandaracinobacteroides hominis gen. nov., sp. nov., isolated from human skin - Ping-Hua Qu; Hai-Min Luo; Jun-Hui Feng; Song Li; Cha Chen; Lei Dong; Yu-Zhen Ming; Wen-Jun Li; Ying Lin (Archives of Microbiology, 2021)

Genomic molecular signatures determined characterization of Mycolicibacterium gossypii sp. nov., a fast-growing mycobacterial species isolated from cotton field soil - Rui-Rui Huang; Shen-Rong Yang; Cheng Zhen; Xian-Feng Ge; Xin-Kai Chen; Zhi-Qiang Wen; Ya-Nan Li; Wen-Zheng Liu (Antonie van Leeuwenhoek, 2021)

Genomic and transcriptomic insights into the habitat adaptation of the diazotrophic paddy‐field cyanobacterium Nostoc sphaeroides - Zhen Chen; Jin‐Long Shang; Shengwei Hou; Tao Li; Qi Li; Yi‐Wen Yang; Wolfgang R. Hess; Bao‐Sheng Qiu (Environmental Microbiology, 2021)
Summary Nitrogen‐fixing cyanobacteria are common in paddy fields, one of the most productive wetland ecosystems. Here, we present the complete genome of Nostoc sphaeroides, a paddy‐field diazotroph used for food and medicine for more than 1700 years and deciphered the transcriptional regulation during the developmental transition from hormogonia to vegetative filaments with heterocysts. The genome of N. sphaeroides consists of one circular chromosome (6.48 Mb), one of the largest ever reported megaplasmids (2.34 Mb), and seven plasmids. Multiple gene families involved in the adaption to high solar radiation and water fluctuation conditions were found expanded, while genes involved in anoxic adaptation and phosphonate utilization are located on the megaplasmid, suggesting its indispensable role in environmental adaptation. Distinct gene expression patterns were observed during the light‐intensity‐regulated transition from hormogonia to vegetative filaments, specifically, genes encoding proteins involved in photosynthetic light reaction, carbon fixation, nitrogen metabolism and heterocyst differentiation were significantly upregulated, whereas genes related to cell motility were down‐regulated. Our results provide genomic and transcriptomic insights into the adaptation of a filamentous nitrogen‐fixing cyanobacterium to the highly dynamic paddy‐field habitat, suggesting N. sphaeroides as an excellent system to understand the transition from aquatic to terrestrial habitats and to support sustainable rice production.

Experimental study on integrated and autonomous conductivity-temperature-depth (CTD) sensor applied for underwater glider - Bin Lv; Hai-lin Liu; Yi-fan Hu; Cheng-xuan Wu; Jie Liu; Hai-jing He; Jie Chen; Jian Yuan; Zhao-wen Zhang; Lin Cao; Hui Li (Marine Georesources & Geotechnology, 2021)

On the origin of SARS-CoV-2—The blind watchmaker argument - Chung-I Wu; Haijun Wen; Jian Lu; Xiao-dong Su; Alice C. Hughes; Weiwei Zhai; Chen Chen; Hua Chen; Mingkun Li; Shuhui Song; Zhaohui Qian; Qihui Wang; et al. (Science China Life Sciences, 2021)

Impacts of land use change on ecosystem service value in Lijiang River Basin, China - Ning Li; Jinye Wang; Haoyu Wang; Bolin Fu; Jianjun Chen; Wen He (Environmental Science and Pollution Research, 2021)

Acute associations between air pollution on premature rupture of membranes in Hefei, China - Chao Zhang; Sha Li; Gan-lan Guo; Jing-wen Hao; Peng Cheng; Li-lin Xiong; Shu-ting Chen; Ji-yu Cao; Yu-wen Guo; Jia-hu Hao (Environmental Geochemistry and Health, 2021)

Apigenin Improves Hypertension and Cardiac Hypertrophy Through Modulating NADPH Oxidase-Dependent ROS Generation and Cytokines in Hypothalamic Paraventricular Nucleus - Hong-Li Gao; Xiao-Jing Yu; Han-Bo Hu; Qian-Wen Yang; Kai-Li Liu; Yan-Mei Chen; Yan Zhang; Dong-Dong Zhang; Hua Tian; Guo-Qing Zhu; Jie Qi; Yu-Ming Kang (Cardiovascular Toxicology, 2021)

Low-latitude control on sea surface temperatures in the middle Okinawa Trough over the last 3.6 kyr - Fangjian Xu; Yanguang Dou; Jingtao Zhao; Jun Li; Xiting Liu; Kehui Xu; Feng Cai; Zhenhe Wen; Xiaohui Chen (Geo-Marine Letters, 2021)

A novel anellovirus from hospitalized neonates - Hong Li; Yuqing Xiao; Heteng Zhang; Xu Chen; Jinquan Lv; Shixing Yang; Hongyan Lu; Wen Zhang (Archives of Virology, 2021)

Effects of ultrasound on functional properties, structure and glycation properties of proteins: a review - Derong Lin; Qiuting Zhang; Lijuan Xiao; Yichen Huang; Zhengfang Yang; Zhijun Wu; Zongcai Tu; Wen Qin; Hong Chen; Dingtao Wu; Qing Zhang; Suqing Li (Critical Reviews in Food Science and Nutrition, 2021)

Estimation of the hydraulic properties of a fractured aquifer using numerical experiments with the discrete fracture network model - Yaqiang Wei; Jian Chen; Lu Li; Ganghui Zhu; Yi Wen (Hydrological Sciences Journal, 2021)

Corticosterone Can Be an Essential Stress Index in Channel Catfish (Ictalurus punctatus) - Kang Xiao; Xi Wang; Wen-Bin Liu; Ding-Dong Zhang; Xiang-Fei Li; Chun-Nuan Zhang; Wei-Hua Chen; Kenneth Prudence Abasubong; Guang-Zhen Jiang (Frontiers in Marine Science, 2021)
Although cortisol is considered the main glucocorticoid involved in regulating stress in fish by elevating the serum glucose, the presence of serum corticosterone and whether its level can be used as an indicator for fish stress activation and reflect the degree of fish stress remains to be determined. To comprehensively and accurately evaluate the performance of two glucocorticoids after stress, in this study, seven of the most common stressors (ammonia nitrogen, high-temperature, acid, alkali, Aeromonas hydrophila, and salinity) in aquaculture were selected. The levels of serum corticosterone, cortisol, and glucose were detected within 48 h, and then the dynamic changes were analyzed. In addition, the kidneys were collected to detect the expression of corresponding proteins involved in corticosterone and cortisol synthesis (3 β-HSD and CYP17A1) for further exploration. From the results obtained, the content of serum corticosterone was about 100 times higher than that of cortisol, and it was found that corticosterone and cortisol showed different dynamic changes within 48 h among the seven kinds of stress. In the subsequent detection of glucose, it was found that the dynamic shift in glucose was not consistent with the dynamic changes of corticosterone or cortisol entirely but seemed to be caused by the combination of the two. In the follow-up protein expression detection, we found that corticosterone seemed to respond to stress earlier. Therefore, it is concluded that the responses of corticosterone and cortisol to stress are independent, corticosterone may be more sensitive in the current seven acute stresses, and then they regulate glucose together to resist stress. The study aimed to fill the vacancy of corticosterone in fish research and provide a reference for the complete evaluation of fish stress degree.

Pinocembrin-7-Methylether Protects SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Neurotoxicity via Modulating Nrf2 Induction Through AKT and ERK Pathways - Zhi-Cong Zou; Ji-Jun Fu; Yuan-Ye Dang; Qian Zhang; Xiu-Fen Wang; Han-Bin Chen; Xue-Jing Jia; Simon Ming-Yuen Lee; Chu-Wen Li (Neurotoxicity Research, 2021)

Chronic Cyanuric Acid Exposure Depresses Hippocampal LTP but Does Not Disrupt Spatial Learning or Memory in the Morris Water Maze - Wei Sun; Yang Yang; Zexiang Wu; Xiao Chen; Wen Li; Lei An (Neurotoxicity Research, 2021)

LncRNA TUG1 exhibits pro-fibrosis activity in hypertrophic scar through TAK1/YAP/TAZ pathway via miR-27b-3p - Xian-Min Li; Wen-Yuan Yu; Qi Chen; Hui-Ru Zhuang; Su-Yue Gao; Tian-Lan Zhao (Molecular and Cellular Biochemistry, 2021)

Overexpression of Cell-Surface Marker SLC16A1 Shortened Survival in Human High-Grade Gliomas - Hong-Han Lin; Wen-Chiuan Tsai; Chia-Kuang Tsai; Ssu-Han Chen; Li-Chun Huang; Dueng-Yuan Hueng; Kuang-Chen Hung (Journal of Molecular Neuroscience, 2021)

A novel lymphatic pattern promotes metastasis of cervical cancer in a hypoxic tumour-associated macrophage-dependent manner - Xiao-Jing Chen; Wen-Fei Wei; Zi-Ci Wang; Nisha Wang; Chu-Hong Guo; Chen-Fei Zhou; Luo-Jiao Liang; Sha Wu; Li Liang; Wei Wang (Angiogenesis, 2021)
Lymphatic remodelling in the hypoxic tumour microenvironment (TME) is critically involved in the metastasis of cervical squamous cell carcinoma (CSCC); however, its underlying mechanisms remain unclear. Here, we uncovered a novel lymphatic pattern in the hypoxic TME, wherein lymphatic vessels (LVs) are encapsulated by tumour-associated macrophages (TAMs) to form an interconnected network. We describe these aggregates as LVEM (LVs encapsulated by TAMs) considering their advantageous metastatic capacity and active involvement in early lymph node metastasis (LNM). Mechanistic investigations revealed that interleukin-10 (IL-10) derived from hypoxic TAMs adjacent to LVs was a prerequisite for lymphangiogenesis and LVEM formation through its induction of Sp1 upregulation in lymphatic endothelial cells (LECs). Interestingly, Sp1 high LECs promoted the transactivation of C–C motif chemokine ligand 1 (CCL1) to facilitate TAM and tumour cell recruitment, thereby forming a positive feedback loop to strengthen the LVEM formation. Knockdown of Sp1 or blockage of CCL1 abrogated LVEM and consequently attenuated LNM. Notably, CSCC non-LNM is largely devoid of hypoxic TAMs and the resultant LVEM, which might explain its metastatic delay. These findings identify a novel and efficient metastasis-promoting lymphatic pattern in the hypoxic TME, which might provide new targets for anti-metastasis therapy and prognostic assessment.

Geographic and subsequent biotic isolations led to a diversity anomaly of section Heterotropa (genus Asarum : Aristolochiaceae) in insular versus continental regions of the Sino‐Japanese Floristic Region - Daiki Takahashi; Shota Sakaguchi; Yu Feng; Yuji Isagi; Ying‐Xiong Qiu; Pan Li; Rui‐Sen Lu; Chang‐Tse Lu; Shih‐Wen Chung; Yang‐Shan Lin; Yun‐Chao Chen; Atsushi J. Nagano; et al. (Journal of Biogeography, 2021)
Aim The Sino‐Japanese Floristic Region has extremely high species diversity with respect to temperate plants; however, the reasons for this diversity are poorly understood because most studies have only considered geographic isolation caused by climatic oscillations. In some plant groups, high floral trait diversity and uneven species diversity between insular systems and the continental area suggest other factors may have important roles too. The primary purpose of this study is to reveal how abiotic and biotic factors have shaped the species diversity anomaly of Heterotropa between the insular systems and the continental area. Location The Sino‐Japanese Floristic Region. Taxon Section Heterotropa (genus Asarum ; Aristolochiaceae). Methods Using ddRAD‐seq and chloroplast genome data, we built a time‐calibrated phylogenetic tree including 79 species. We estimated the patterns of floral traits (flowering time and floral size) evolution using macroevolutionary modelling, and tested the correlation of speciation rate with the trait evolution rates. Finally, we estimated the isolation factors of all taxa pairs and sister‐taxa pairs based on distribution range and floral traits. Results Phylogenetic analysis indicated that Heterotropa was diverged into two clades (continental clade and insular clade) in the Miocene, and the major subclades corresponded to geographic entities. Most rate shifts accelerating floral trait's evolution occurred during the Pleistocene period. Evolution rate of floral traits showed positive correlation with the speciation rate. Large proportion of taxa in the insular clade are distributed allopatrically. Several sister pairs showed floral trait divergence with geographic overlap. Main Conclusions The diversification of Heterotropa appears to have been triggered by geographic and climatic events, and subsequent repeated floral trait evolution with and without geographic isolation. Furthermore, the high species diversity in the insular systems would have been formed by the repeated range fragmentations and contractions. Our study demonstrates the importance of multidimensional studies to understand the diversification process of temperate plants in the Sino‐Japanese Floristic Region.

The developmental regulator PatD modulates assembly of the cell‐division protein FtsZ in the cyanobacterium Anabaena sp. PCC 7120 - Li Wang; Tian‐Cai Niu; Ana Valladares; Gui‐Ming Lin; Ju‐Yuan Zhang; Antonia Herrero; Wen‐Li Chen; Cheng‐Cai Zhang (Environmental Microbiology, 2021)
Summary FtsZ is a tubulin‐like GTPase that polymerizes to initiate the process of cell division in bacteria. Heterocysts are terminally differentiated cells of filamentous cyanobacteria that have lost the capacity for cell division and in which the ftsZ gene is downregulated. However, mechanisms of FtsZ regulation during heterocyst differentiation have been scarcely investigated. The patD gene is NtcA dependent and involved in the optimization of heterocyst frequency in Anabaena sp. PCC 7120. Here, we report that the inactivation of patD caused the formation of multiple FtsZ‐rings in vegetative cells, cell enlargement, and the retention of peptidoglycan synthesis activity in heterocysts, whereas its ectopic expression resulted in aberrant FtsZ polymerization and cell division. PatD interacted with FtsZ, increased FtsZ precipitation in sedimentation assays, and promoted the formation of thick straight FtsZ bundles that differ from the toroidal aggregates formed by FtsZ alone. These results suggest that in the differentiating heterocysts, PatD interferes with the assembly of FtsZ. We propose that in Anabaena FtsZ is a bifunctional protein involved in both vegetative cell division and regulation of heterocyst differentiation. In the differentiating cells PatD‐FtsZ interactions appear to set an FtsZ activity that is insufficient for cell division but optimal to foster differentiation.

Three new 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones and one new dimeric 2-(2-phenylethyl)chromone from agarwood of Aquilaria crassna Pierre ex Lecomte in Laos - Yang-Mei Zhao; Li Yang; Fan-Dong Kong; Wen-Hua Dong; Wei Li; Hui-Qin Chen; Hao Wang; Cai-Hong Cai; Cui-Juan Gai; Wen-Li Mei; Hao-Fu Dai (Natural Product Research, 2021)

Homeobox Gene Six3 is Required for the Differentiation of D2-Type Medium Spiny Neurons - Xiaolei Song; Haotian Chen; Zicong Shang; Heng Du; Zhenmeiyu Li; Yan Wen; Guoping Liu; Dashi Qi; Yan You; Zhengang Yang; Zhuangzhi Zhang; Zhejun Xu (Neuroscience Bulletin, 2021)
Medium spiny neurons (MSNs) in the striatum, which can be divided into D1 and D2 MSNs, originate from the lateral ganglionic eminence (LGE). Previously, we reported that Six3 is a downstream target of Sp8/Sp9 in the transcriptional regulatory cascade of D2 MSN development and that conditionally knocking out Six3 leads to a severe loss of D2 MSNs. Here, we showed that Six3 mainly functions in D2 MSN precursor cells and gradually loses its function as D2 MSNs mature. Conditional deletion of Six3 had little effect on cell proliferation but blocked the differentiation of D2 MSN precursor cells. In addition, conditional overexpression of Six3 promoted the differentiation of precursor cells in the LGE. We measured an increase of apoptosis in the postnatal striatum of conditional Six3 -knockout mice. This suggests that, in the absence of Six3, abnormally differentiated D2 MSNs are eliminated by programmed cell death. These results further identify Six3 as an important regulatory element during D2 MSN differentiation.

Complete genome sequence analysis of a novel coguvirus isolated from Paris polyphylla var. yunnanensis - Zeli Chen; Rex Frimpong Anane; Zhe Wang; Like Gao; Lu Chen; Shangyun Li; Guosong Wen; Mingfu Zhao (Archives of Virology, 2021)

Cysteiniphilum marinum sp. nov., isolated from coastal seawater - Hai-Min Luo; Jun-Hui Feng; Liang-Hui Li; Meng-Meng Li; Ru-Qin Liu; Fu Chen; Ying Lin; Wen-Jun Li; Ping-Hua Qu; Min Xiao (Antonie van Leeuwenhoek, 2021)

Analyzing 13 Years of Cetacean Strandings: Multiple Stressors to Cetaceans in Taiwanese Waters and Their Implications for Conservation and Future Research - Wen-Ta Li; Lien-Siang Chou; Hue-Ying Chiou; I-Hua Chen; Wei-Cheng Yang (Frontiers in Marine Science, 2021)
This study summarizes the postmortem investigations of 73 cetaceans stranded on the coast of Taiwan between 2001 and 2013, including 51 Delphinidae, 17 Kogiidae, 3 Ziphiidae, 1 Physeteridae, and 1 Balaenopteridae. Of these, eight (11%) were categorized into direct human-related strandings, including fisheries interaction (bycatch), vessel collision and other anthropogenic-related pathology. Gastrointestinal foreign bodies were found in eight individuals (11%). Most of the bacteria isolated from stranded dolphins were zoonotic pathogens including extended-spectrum β-lactamases Escherichia coli , which indicates waste pollution from land. Severe parasite infestation was found in 36 of the cases (49%), which suggests that the immune function could be compromised. Thirty-eight cases (52%) were diagnosed with myocardial patchy fibrosis or dilated cardiomyopathy. The evidence shown here indicates that cetaceans around Taiwanese waters may suffer from multiple stressors. This study provides baseline data for the health assessment of cetacean populations in Taiwan, which may ultimately provide recommendations for future cetacean conservation and research throughout the western Pacific.

Quantitative Proteomics Analysis of Sugarcane Ratoon Crop Chlorosis - Ye-Geng Fan; Rong-Fa Chen; Li-Hang Qiu; Zhong-Feng Zhou; Hui-Wen Zhou; Ji-Guang Wei; Xiu-Peng Song; Ting Luo; Prakash Lakshmanan; Xing Huang; Jian-Ming Wu; Yang-Rui Li (Sugar Tech, 2021)

Exploring the Deeper Crustal Structure Beneath the Tatun Volcanic Area, Taiwan - Chien-Min Su; Wei-Jhe Wu; Strong Wen; Yi-Heng Li; Yen-Che Liao; Wen-Yen Chang; Chau-Huei Chen (Pure and Applied Geophysics, 2021)

Using the Metabolome to Understand the Mechanisms Linking Chronic Arsenic Exposure to Microglia Activation, and Learning and Memory Impairment - Rui-Yuan Zhang; Jie-Bai Tu; Rui-Tu Ran; Wen-Xuan Zhang; Qiang Tan; Ping Tang; Tao Kuang; Shu-Qun Cheng; Cheng-Zhi Chen; Xue-Jun Jiang; Chang Chen; Ting-Li Han; et al. (Neurotoxicity Research, 2021)

OsGSTU6 Contributes to Cadmium Stress Tolerance in Rice by Involving in Intracellular ROS Homeostasis - Xiu-Qing Jing; Meng-Ru Zhou; Xiu-Min Nie; Lu Zhang; Peng-Tao Shi; Abdullah Shalmani; Hai Miao; Wen-Qiang Li; Wen-Ting Liu; Kun-Ming Chen (Journal of Plant Growth Regulation, 2021)

Enhancement of IUdR Radiosensitization in Cancer Therapy by Low-Energy Transmission X Ray Irradiation - Chien-Chih Ke; Jia-Je Li; Hsueh-Peng Wu; Wen-Wang Kuo; Yi-An Chen; Cheng-Hsiu Lu; Hsin-Ell Wang; Shih-Ming Hsu; Ya-Ju Hsieh; Ren-Shyan Liu (Journal of Medical and Biological Engineering, 2021)

Effects of calcium ion on the colony formation, growth, and photosynthesis in the edible cyanobacterium Nostoc sphaeroides - Zhen Chen; Wei-Zhi Li; Jing-Yuan Chen; Zu-Wen Yuan; Xiong-Wen Chen (Journal of Applied Phycology, 2021)

Enhanced treatment of shale gas fracturing waste fluid through plant-microbial synergism - Bo Shao; Xu Tan; Ju-Long Li; Mei He; Lei Tian; Wen-Jie Chen; Yan Lin (Environmental Science and Pollution Research, 2021)

Geological controls of shale gas accumulation and enrichment mechanism in Lower Cambrian Niutitang Formation of western Hubei, Middle Yangtze, China - Lulu Xu; Saipeng Huang; Zaoxue Liu; Yaru Wen; Xianghui Zhou; Yanlin Zhang; Xiongwei Li; Deng Wang; Fan Luo; Cheng Chen (Frontiers of Earth Science, 2021)

Characterization of Water Quality in Xiao Xingkai Lake: Implications for Trophic Status and Management - Shuling Yu; Xiaoyu Li; Bolong Wen; Guoshuang Chen; Anne Hartleyc; Ming Jiang; Xiujun Li (Chinese Geographical Science, 2021)

Synthesis and antitumor evaluation of (aryl)methyl-amine derivatives of dehydroabietic acid-based B ring-fused-thiazole as potential PI3K/AKT/mTOR signaling pathway inhibitors - Nai-Yuan Chen; Yu-Lan Xie; Guo-Dong Lu; Fang Ye; Xin-Yu Li; Yu-Wen Huang; Ming-Li Huang; Tie-Yu Chen; Cui-Ping Li (Molecular Diversity, 2021)

Design, synthesis and evaluation of dihydrotriazine derivatives-bearing 5-aryloxypyrazole moieties as antibacterial agents - Tian-Yi Zhang; Chun-Shi Li; Ming-Yue Cui; Xue-Qian Bai; Jiang-Hui Chen; Ze-Wen Song; Bo Feng; Xue-Kun Liu (Molecular Diversity, 2021)

First report of cucurbit chlorotic yellows virus infecting melon, watermelon and wild melon in the Philippines - Hsin-Yi Chang; Li-Cheng Chen; Chung-Cheng Lin; Wen-Shi Tsai (Journal of Plant Pathology, 2021)