Contrasting effects of plant-soil feedbacks on growth and morphology of physically-connected daughter and mother ramets in two clonal plants - Wei Xue; Lin Huang; Wei-Jia Sheng; Jia-Tao Zhu; Shu-Qi Li; Fei-Hai Yu (Plant and Soil, 2022)

Establishment of Galectin-3 Time-resolved Fluoroimmunoassay and its Application in Idiopathic Membranous Nephropathy - Xiaomei Yu; Lingli Chen; Bo Lin; Li Zhang; Xue Yang; Xiaobin Liu; Pengguo Xia; Yueming Liu; Shaoxiong Zheng; Xiumei Zhou; Yigang Wang; Yuan Qin; et al. (Journal of Fluorescence, 2022)

Association between maternal exposure to PM10 and risk of anorectal atresia/stenosis in offspring: a population-based case-control study in Liaoning Province, China - Tie-Ning Zhang; Qi-Jun Wu; Yan-Hong Huang; Jing Li; Zong-Jiao Chen; Li-Li Li; Yan-Ling Chen; Shu Liu; Cheng-Zhi Jiang; Yu-Hong Zhao (Environmental Science and Pollution Research, 2022)

Enhanced cadmium removal by growing Bacillus cereus RC-1 immobilized on different magnetic biochars through simultaneous adsorption and bioaccumulation - Min Deng; Kai Li; Yu-Jian Yan; Fei Huang; Dan Peng (Environmental Science and Pollution Research, 2022)

Projected change in precipitation forms in the Chinese Tianshan Mountains based on the Back Propagation Neural Network Model - Rui Ren; Xue-mei Li; Zhen Li; Lan-hai Li; Yi-yu Huang (Journal of Mountain Science, 2022)

Complete genome sequence of a novel virga-like virus infecting Hevea brasiliensis - Sixi Chen; Fengjuan Yu; Zhaotong Li; Yonglei Zhang; Hongxing Wang; Jinling Zhai; Xi Huang (Archives of Virology, 2022)

Genetic Diversity and Structure of Tropical Porites lutea Populations Highlight Their High Adaptive Potential to Environmental Changes in the South China Sea - Yanqiu Luo; Wen Huang; Kefu Yu; Ming Li; Biao Chen; Xueyong Huang; Zhenjun Qin (Frontiers in Marine Science, 2022)
Global climate change and anthropogenic disturbance have significantly degraded biodiversity in coral reef ecosystems. The genetic potential and adaptability of corals are key factors used to predict the fate of global coral reefs under climate change. In this study, we used eight microsatellite loci to study the patterns of reproduction, genetic diversity, and genetic structure of 302 Porites lutea samples across 13° latitudes in the South China Sea (8.8644°N–22.6117°N). The results indicated that P. lutea reproduces largely via sexual reproduction on scales of 5 m and greater and has abundant gene diversity. Additionally, the tropical populations harbored high genetic diversity (based on alleles, effective number of alleles, gene diversity, and heterozygosity). In contrast, genetic diversity was lower in subtropical coral populations. Genetic variation values and pairwise F ST revealed that tropical and subtropical populations had significantly different genetic structures. Finally, the Mantel tests showed that the genetic differentiation and genetic variation of P. lutea were strongly correlated with sea surface temperature and slightly correlated with geographical distance. These results indicated that tropical P. lutea populations have high genetic potential and adaptability because of their sexual reproduction and genetic diversity, giving them a greater capacity to cope with climate change. Subtropical coral populations showed lower genetic diversity and, thus, relatively poor genetic resilience in response to low average sea surface temperature and human activities. Our study provides a theoretical basis for the protection and restoration of coral reefs.

Population Genomics, Transcriptional Response to Heat Shock, and Gut Microbiota of the Hong Kong Oyster Magallana hongkongensis - Yichun Xie; Elaine Y. Y. Huang; Wenyan Nong; Sean T. S. Law; Yifei Yu; Khan Cheung; Yiqian Li; Cheuk Fung Wong; Ho Yin Yip; Patrick W. S. Joyce; King Ming Chan; Ka Hou Chu; et al. (Journal of Marine Science and Engineering, 2022)
The Hong Kong oyster Magallana hongkongensis, previously known as Crassostrea hongkongensis, is a true oyster species native to the estuarine-coast of the Pearl River Delta in southern China. The species—with scientific, ecological, cultural, and nutritional importance—has been farmed for hundreds of years. However, there is only limited information on its genetics, stress adaptation mechanisms, and gut microbiota, restricting the sustainable production and use of oyster resources. Here, we present population structure analysis on M. hongkongensis oysters collected from Deep Bay and Lantau Island in Hong Kong, as well as transcriptome analysis on heat shock responses and the gut microbiota profile of M. hongkongensis oysters collected from Deep Bay. Single nucleotide polymorphisms (SNPs), including those on the homeobox genes and heat shock protein genes, were revealed by the whole genome resequencing. Transcriptomes of oysters incubated at 25 °C and 32 °C for 24 h were sequenced which revealed the heat-induced regulation of heat shock protein pathway genes. Furthermore, the gut microbe community was detected by 16S rRNA sequencing which identified Cyanobacteria, Proteobacteria and Spirochaetes as the most abundant phyla. This study reveals the molecular basis for the adaptation of the oyster M. hongkongensis to environmental conditions.

Four new prenylflavonol glycosides from the leaves of Cyclocarya paliurus - Zi-Jun Ye; Hui-Hui Sun; Zu-Hui Chen; Jian-Ping Wu; Jing Li; Hui Zhu; Lu-Lu Huang; Xi-Wen Chang; Sai-Yu Ou; Wen-Xuan Wang; Xiao-Ai He; Gang-Zhi Zhu; et al. (Natural Product Research, 2022)

White Matter Free Water is a Composite Marker of Cerebral Small Vessel Degeneration - Peiyu Huang; Ruiting Zhang; Yeerfan Jiaerken; Shuyue Wang; Hui Hong; Wenke Yu; Chunfeng Lian; Kaicheng Li; Qingze Zeng; Xiao Luo; Xinfeng Yu; Xiao Wu; et al. (Translational Stroke Research, 2022)

Clinical Characteristics and Outcomes of Rare Fungal Keratitis Caused by Verticillium dahliae - Qing Huang; Wenlu Zhang; Yu Sun; Xiaofeng Li; Xiaoyu Zhang; Xiuhai Lu; Xiaolin Qi (Mycopathologia, 2022)

Consistent responses of microbial C and N metabolic processes to elevated CO2 across global terrestrial ecosystems - Jiahui Lin; Yanlan Huang; Haochun Zhao; Mengjie Yu; Weiqin Su; Huaihai Chen; Peng Leng; Jihui Li; Yu Luo; Yong Li; Zhongmin Dai; Jianming Xu (Journal of Soils and Sediments, 2022)

Caveolin-1 knockout mice have altered serum N-glycan profile and sialyltransferase tissue expression - Xixi Chen; Liping Wang; Yinshuang Wu; Hongshuo Zhang; Weijie Dong; Xiao Yu; Chuncui Huang; Yan Li; Shujing Wang; Jianing Zhang (Journal of Physiology and Biochemistry, 2022)

The neonatal PROC gene rs1799809 polymorphism modifies the association between prenatal air pollutants exposure and PROC promoter methylation - Zhiyuan Li; Meng Yang; Leizhen Duan; Yongxiang Gong; Hongxia Xia; Francis-Kojo Afrim; Hui Huang; Xiaoxue Liu; Fangfang Yu; Yawei Zhang; Yue Ba; Guoyu Zhou (Environmental Science and Pollution Research, 2022)

The characteristics of habitat, functional traits and medicinal components of Eucommia ulmoides from Guizhou - Changjiang Qian; Rongrong Zhang; Jia Li; Zongsheng Huang; Xun Liu; Lifei Yu; Lingbin Yan; Yuhong Fu (Environmental Science and Pollution Research, 2022)

Selenium Deficiency Causes Inflammatory Injury in the Bursa of Fabricius of Broiler Chickens by Activating the Toll-like Receptor Signaling Pathway - Yu Bai; Ruili Zhang; Qing Liu; Rong Guo; Guangxing Li; Bin Sun; Di Zhang; Yang Chen; Xiaodan Huang (Biological Trace Element Research, 2022)

Secondary metabolites isolated from Agrimonia pilosa Ledeb. - Hong-Rui Li; Yu-Kui Li; Jian Xiao; Cui Yang; Meng-Yuan Jiang; Kai Tian; Wei Wang; Yan-Hong Li; Xiang-Zhong Huang (Natural Product Research, 2022)

Fruit and vegetable consumption, cardiovascular disease, and all-cause mortality in China - Jun Wang; Fangchao Liu; Jianxin Li; Keyong Huang; Xueli Yang; Jichun Chen; Xiaoqing Liu; Jie Cao; Shufeng Chen; Chong Shen; Ling Yu; Fanghong Lu; et al. (Science China Life Sciences, 2022)

HMGB1-RAGE Pathway Contributes to the Abnormal Migration of Endogenous Subventricular Zone Neural Progenitors in an Experimental Model of Focal Microgyria - Yi-Wen Mei; Tian-Lan Huang; Xin Chen; Si-Xun Yu; Jie Li; Zhi Zhang; Yang He; Da-qing Guo; Hai-Feng Shu (Journal of Molecular Neuroscience, 2022)

The changes of rhizosphere characteristics contributed to enhanced Pb accumulation in Athyrium wardii (Hook.) Makino after nitrilotriacetic acid application - Yunhong Zhang; Huagang Huang; Haiying Yu; Juan Zhan; Daihua Ye; Zicheng Zheng; Xizhou Zhang; Yongdong Wang; Tingxuan Li (Environmental Science and Pollution Research, 2022)

Nanoscale zero-valent iron particles supported on sludge-based biochar for the removal of chromium (VI) from aqueous system - Xi Chen; Guangjian Fan; Haibo Li; Yinghua Li; Ran Zhang; Yu Huang; Xinyang Xu (Environmental Science and Pollution Research, 2022)

Isolation, characterization, and evaluation of a high-siderophore-yielding bacterium from heavy metal–contaminated soil - Yajun Wang; Wei Huang; Yaqian Li; Fangbo Yu; Petri Penttinen (Environmental Science and Pollution Research, 2022)

Paracoccus shandongensis sp. nov., Isolated from Activated Sludge - Xiao-Fan Gong; Fang Wang; Dong Meng; Yu-Ling Liu; Peng-Fei Gu; Xiang-Yu Fan; Zhao-Song Huang; Zong-Jun Du; Qiang Li (Current Microbiology, 2022)

A hybrid cluster-borderline SMOTE method for imbalanced data of rock groutability classification - Kai Li; Bingyu Ren; Tao Guan; Jiajun Wang; Jia Yu; Kexiang Wang; Jicun Huang (Bulletin of Engineering Geology and the Environment, 2022)

Experimental mechanical strength and deformation characteristics of deep damaged–fractured rock - Qing-Bin Meng; Jiang-Feng Liu; Li-Xiang Xie; Hai Pu; Yu-Gui Yang; Bing-Xiang Huang; Wei Qian (Bulletin of Engineering Geology and the Environment, 2022)

Mesorhizobium xinjiangense sp. nov., isolated from rhizosphere soil of Alhagi sparsifolia - Dong Meng; Yu-Ling Liu; Jun-Jie Zhang; Peng-Fei Gu; Xiang-Yu Fan; Zhao-Song Huang; Yan Ji; Heng Meng; Zong-Jun Du; Wei-Min Li; Qiang Li (Archives of Microbiology, 2022)

Nakamurella leprariae sp. nov., isolated from a lichen sample - De-Feng An; Shao-Juan Yang; Long-Qian Jiang; Xin-Yu Wang; Xiao-Yu Huang; Lei Lang; Xue-Mei Chen; Ming-Qun Fan; Gui-Ding Li; Ming-Guo Jiang; Li-Song Wang; Cheng-Lin Jiang; et al. (Archives of Microbiology, 2022)

Production forecast of fractured vertical wells in coalbed methane reservoirs: coupling dynamic drainage area - Zheng Sun; Bingxiang Huang; Yaohui Li; Weichao Yu; Liang Ji (Arabian Journal of Geosciences, 2022)

Spatiotemporal characteristics of human activity on coastal landscape of Laizhou Bay - Fan Yang; Jie Li; Jiaqing Wang; Jiantao Huang; Tong Qi; Yiman Liu; Tianyu Fu; Shuting Yu; Lingyan Zhao (Wetlands Ecology and Management, 2021)

Identification of New Transcription Factors that Can Promote Pluripotent Reprogramming - Ping Huang; Jieying Zhu; Yu Liu; Guihuan Liu; Ran Zhang; Dongwei Li; Duanqing Pei; Ping Zhu (Stem Cell Reviews and Reports, 2021)
Background Four transcription factors, Oct4, Sox2, Klf4, and c-Myc (the Yamanka factors), can reprogram somatic cells to induced pluripotent stem cells (iPSCs). Many studies have provided a number of alternative combinations to the non-Yamanaka factors. However, it is clear that many additional transcription factors that can generate iPSCs remain to be discovered. Methods The chromatin accessibility and transcriptional level of human embryonic stem cells and human urine cells were compared by Assay for Transposase-Accessible Chromatin with high-throughput sequencing (ATAC-seq) and RNA sequencing (RNA-seq) to identify potential reprogramming factors. Selected transcription factors were employed to reprogram urine cells, and the reprogramming efficiency was measured. Urine-derived iPSCs were detected for pluripotency by Immunofluorescence, quantitative polymerase chain reaction, RNA sequencing and teratoma formation test. Finally, we assessed the differentiation potential of the new iPSCs to cardiomyocytes in vitro. Results ATAC-seq and RNA-seq datasets predicted TEAD2, TEAD4 and ZIC3 as potential factors involved in urine cell reprogramming. Transfection of TEAD2, TEAD4 and ZIC3 (in the presence of Yamanaka factors) significantly improved the reprogramming efficiency of urine cells. We confirmed that the newly generated iPSCs possessed pluripotency characteristics similar to normal H1 embryonic stem cells. We also confirmed that the new iPSCs could differentiate to functional cardiomyocytes. Conclusions In conclusion, TEAD2, TEAD4 and ZIC3 can increase the efficiency of reprogramming human urine cells into iPSCs, and provides a new stem cell sources for the clinical application and modeling of cardiovascular disease. Graphical abstract

Adult-repopulating lymphoid potential of yolk sac blood vessels is not confined to arterial endothelial cells - Chaojie Wang; Yandong Gong; Anbang Wei; Tao Huang; Siyuan Hou; Junjie Du; Zongcheng Li; Junliang Wang; Bing Liu; Yu Lan (Science China Life Sciences, 2021)

Realization of Natural Human Motion on a 3D Biped Robot For Studying the Exoskeleton Effective - Chi-Ying Lee; Shih Chieh Lan; Jung-Ji Lin; Yu-Ting Lin; Po-Shen Chiang; Wei-Li Hsu; Kuo-Kuang Jen; Andy Y. S. Huang; Jia-Yush Yen (Journal of Medical and Biological Engineering, 2021)

Dexmedetomidine attenuates haemorrhage-induced thalamic pain by inhibiting the TLR4/NF-κB/ERK1/2 pathway in mice - Tianfeng Huang; Yong Li; Wenqing Hu; Dapeng Yu; Ju Gao; Fan Yang; Yingying Xu; Zehua Wang; Liang Zong (Inflammopharmacology, 2021)
Background Thalamic pain, a neuropathic pain syndrome, frequently occurs after stroke. This research aimed to investigate the effect of dexmedetomidine (DEX) on thalamic pain. Methods The cellular localization of the TLR4 protein was determined by immunostaining. The expression of Iba1, GFAP and protein associated with the TLR4/NF-κB/ERK1/2 pathway was measured by Western blotting. Continuous pain hypersensitivity was evaluated by behavioural tests. The results were analysed by one-way ANOVA, two-way ANOVA and Tukey’s post hoc test. Results The results demonstrated that DEX obviously alleviated thalamic pain induced by haemorrhage on the ipsilateral side and delayed the development of pain hypersensitivity. Furthermore, the expression levels of Iba1, GFAP and proteins associated with the TLR4/NF-κB/ERK1/2 signalling pathway were greatly increased in mice with thalamic pain, but these effects were reversed by DEX. Conclusion Our findings suggest that DEX alleviates the inflammatory response during thalamic pain through the TLR4/NF-κB/ERK1/2 signalling pathway and might be a potential therapeutic agent for thalamic pain.

Dinoflagellate-targeted PCR reveals highly abundant and diverse communities of parasitic dinoflagellates in and near Zhubi Reef, South China Sea - Dajun Qiu; Liangmin Huang; Yunyun Zhuang; Yu Zhong; Yuehui Tan; Xiubao Li; Sheng Liu; Hui Huang; Senjie Lin (Coral Reefs, 2021)

Analysis of deformation control mechanism of prestressed anchor on jointed soft rock in large cross-section tunnel - Gan Li; Yu Hu; Si-ming Tian; Ma weibin; Hai-long Huang (Bulletin of Engineering Geology and the Environment, 2021)

Development and characterization of SNP markers in many-lined sun skink (Eutropis multifasciata) from transcriptomic sequences - Youfu Lin; Zijin Qian; Shiyu Shen; Yicheng Huang; Yu Du; Hong Li; Lian Chen (Conservation Genetics Resources, 2021)

Rapid visual detection of Aeromonas salmonicida by loop‐mediated isothermal amplification with hydroxynaphthol blue dye - Shun Zhou; Qing Huang; Mingming Yu; Ying Li; Xujia Zheng; Yunji Xiu (Journal of Fish Diseases, 2021)
To make crucial prevention, reduce fish losses and minimize the economic damage of diseases on the fish farm owners, a rapid detection of fish pathogens is mandatory. In this study, a loop‐mediated isothermal amplification assay combined with hydroxynaphthol blue dye (LAMP‐HNB) was developed and used for the rapid detection of Aeromonas salmonicida that caused significant economic losses in fish farming. Firstly, a pair of outer and inner primers specific for conserved fragment of vapA gene in A. salmonicida were designed and synthesized. Secondly, by optimizing the reaction conditions including reaction temperature, time, Mg 2+ concentration, dNTP concentration and primer ratio, a LAMP‐HNB assay was successfully established for the detection of A. salmoncida . Thirdly, the assay showed good specificity with no false‐positive and false‐negative results, and good sensitivity with the detection limit of 3.077 × 10 –6 ng/μl, which was 10 2 times more sensitive than the conventional PCR. Finally, the LAMP‐HNB assay was validated by the fish samples inoculated with different concentrations of A. salmoncida . This is the first development of rapid visual detection of A. salmonicida based on LAMP‐HNB assay, which has great application prospect and market for diagnostic testing, health certification and active surveillance programmers.

Sedimentary Sequence, Evolution Model and Petroleum Geological Significance of Forced Regression: A Case Study of the Miocene Zhujiang Formation of the Pearl River Mouth Basin in the Northern South China Sea - Ye Yu; Linghui Cai; Changmin Zhang; Li Wang; Rui Zhu; Yanran Huang; Taotao Cao (Journal of Marine Science and Engineering, 2021)
Using 2D/3D seismic data and a large number of drilling and logging data and applying sequence stratigraphy, seismic sedimentology, and petroleum geology concepts, the characteristics of the sedimentary sequence of the forced regression have been analysed, the migration trajectory of the coastline have been reconstructed, the evolution model of the forced regression have been presented, and the significance for petroleum geology of the forced regressive sandbodies have been discussed. The falling stage systems tract (FSST) of the Zhujiang Formation present offlap high-angle oblique foreset reflection structure in the seismic profiles of the depositional trends and turbidite fan deposits with strong amplitude mound reflection structure are developed in the downdip direction of its front. The trajectory of migration of the shoreline shows a terraced downtrend in the direction of basin. The FSST is characterized by the shelf-edge delta without topset beds. The FSST was formed in the fall of relative sea-level. Five sets of foreset beds controlled by high-frequency relative eustatic were developed, therefore ordinal regressive overlap can be observed for the five sets of shelf-edge deltas in the depositional trends. The favourable reservoirs which were located close to the upper boundary of the falling stage systems tract and the basal surface of forced regression are sandbodies of the shelf-edge delta front and wave-dominated shoreface sands and the sandbodies of the turbidite fan. Those sandbodies favour the formation of lithologic oil–gas reservoirs by means of good trap sealing conditions, excellent oil–gas reserving performance, and effective oil source communication of fracture system.

Exosome-derived SNHG16 sponging miR-4500 activates HUVEC angiogenesis by targeting GALNT1 via PI3K/Akt/mTOR pathway in hepatocellular carcinoma - Shuangda Li; Yu Qi; Yiran Huang; Yanru Guo; Tong Huang; Li Jia (Journal of Physiology and Biochemistry, 2021)

FOXA2 inhibits doxorubicin-induced apoptosis via transcriptionally activating HBP rate-limiting enzyme GFPT1 in HCC cells - Huang Huang; Yuhan Wang; Tianmiao Huang; Lingyan Wang; Yangzhi Liu; Qiong Wu; Ang Yu; Meiyun Shi; Xiaoyu Wang; Wenli Li; Jianing Zhang; Yubo Liu (Journal of Physiology and Biochemistry, 2021)

Exposure to 2,4-dichlorophenol, 2,4,6-trichlorophenol, pentachlorophenol and risk of thyroid cancer: a case-control study in China - Wan-Jun Yang; Hua-Bing Wu; Chi Zhang; Qi Zhong; Ming-Jun Hu; Jia-Liu He; Guo-Ao Li; Zhen-Yu Zhu; Jin-Liang Zhu; Huan-Huan Zhao; Han-Shuang Zhang; Fen Huang (Environmental Science and Pollution Research, 2021)

Hydrological characteristics and changes in the Nu-Salween River basin revealed with model-based reconstructed data - Fan Yang; Hui Lu; Kun Yang; Guang-wei Huang; Yi-shan Li; Wei Wang; Ping Lu; Fu-qiang Tian; Yu-gang Huang (Journal of Mountain Science, 2021)

Induced production of a new polyketide in Penicillium sp. HS-11 by chemical epigenetic manipulation - You-Min Ying; Ling Li; Hang-Fei Yu; Yi-Lian Xu; Lu Huang; Wei Mao; Cui-Ping Tong; Zhi-Dong Zhang; Zha-Jun Zhan; Yun Zhang (Natural Product Research, 2021)

Zebrafish as a Model for In-Depth Mechanistic Study for Stroke - Weijie Chen; Lv Xie; Fang Yu; Yan Li; Chen Chen; Wanqing Xie; Tingting Huang; Yueman Zhang; Song Zhang; Peiying Li (Translational Stroke Research, 2021)

AFAP1-AS1: a rising star among oncogenic long non-coding RNAs - Fang Xiong; Kunjie Zhu; Su Deng; Hongbin Huang; Liting Yang; Zhaojian Gong; Lei Shi; Yi He; Yanyan Tang; Qianjin Liao; Jianjun Yu; Xiaoling Li; et al. (Science China Life Sciences, 2021)

An atlas of CNV maps in cattle, goat and sheep - Yongzhen Huang; Yunjia Li; Xihong Wang; Jiantao Yu; Yudong Cai; Zhuqing Zheng; Ran Li; Shunjin Zhang; Ningbo Chen; Hojjat Asadollahpour Nanaei; Quratulain Hanif; Qiuming Chen; et al. (Science China Life Sciences, 2021)

Human activity and climate change triggered the expansion of rocky desertification in the karst areas of Southwestern China - Chaojun Chen; Daoxian Yuan; Hai Cheng; Tsailuen Yu; Chuanchou Shen; R. Lawrence Edwards; Yao Wu; Siya Xiao; Jian Zhang; Tao Wang; Ran Huang; Ziqi Liu; et al. (Science China Earth Sciences, 2021)

Social disruption–induced stress pre-exposure aggravates, while the presence of conspecifics diminishes, acetic acid–induced writhing - Yi-Han Liao; Yi-Chi Su; Yu-Han Huang; Hao Chen; Ya-Hsuan Chan; Li-Han Sun; Chianfang G. Cherng; Ing-Tiau B. Kuo; Lung Yu (Psychopharmacology, 2021)

The characterization and candidate gene isolation for a novel male-sterile mutant ms40 in maize - Xiaowei Liu; Yujing Yue; Zicheng Gu; Qiang Huang; Zijin Pan; Zhuofan Zhao; Mingmin Zheng; Zhiming Zhang; Chuan Li; Hongyang Yi; Tao Yu; Moju Cao (Plant Cell Reports, 2021)

SETD3 Downregulation Mediates PTEN Upregulation-Induced Ischemic Neuronal Death Through Suppression of Actin Polymerization and Mitochondrial Function - Xiangyu Xu; Yu Cui; Congqin Li; Yuyang Wang; Jing Cheng; Songfeng Chen; Jiangdong Sun; Jinyang Ren; Xujin Yao; Jingchen Gao; Xiaohong Huang; Qi Wan; et al. (Molecular Neurobiology, 2021)

The impacts of different anticoagulants and long-term frozen storage on multiple metal concentrations in peripheral blood: a comparative study - Yu Bao; Xiaoting Ge; Longman Li; Junxiu He; Sifang Huang; Xiaoyu Luo; Xing Chen; Pan Chen; Xiaobo Yang (BioMetals, 2021)

Improper Diving Behavior Affects Physiological Responses of Acropora hyacinthus and Porites cylindrica - Yu Zhang; Jianzhong Huang; Xinke Li; Cuiping Song; Jingquan Xia; Yuxiao Ren; Aimin Wang; Xiubao Li (Frontiers in Marine Science, 2021)
Human activities beyond ecosystem capacity have resulted in serious effects on corals worldwide. Nowadays, many studies have focused on the influence of diving activities on coral communities, while the knowledge of physiological changes under corresponding environmental stresses remains largely undetermined. In the study, we aimed to investigate the physiological effects of touching, ammonia nitrogen enrichment (5 μmol⋅L –1 ), and sediment cover (particle size of less than 0.3 mm), which simulated improper self-contained underwater breathing apparatus (SCUBA) diving behaviors, on Acropora hyacinthus and Porites cylindrica in Wuzhizhou Island, the South China Sea. For A. hyacinthus , continuous touching caused the tentacles to shrink and secrete mucus, which consumed energy and dissolved oxygen. The skeletal growth rate was decreased by 72% compared with the control group. There was a rapid decline of Fv/Fm and alpha under the dual impacts of high ammonia nitrogen and touching, while the Chl a concentration and tissue biomass were decreased by 36 and 28% compared with touching alone, respectively. High ammonia nitrogen and touching increased the concentrations of lipid and protein. Nevertheless, zooxanthellae density was increased by 23% to relieve the effects of a lower concentration of Chl a in a high nutrient environment. Constant touching and sediment cover in diving areas with elevated ammonia content affected the photosynthesis and respiration of corals, and a significant decrease was observed for lipid, zooxanthellae density, and Chl a concentration. Coral bleaching occurred on day 7. For P. cylindrica , the decreasing magnitude of Fv/Fm and alpha under different stresses in the subsequent phase was less compared with A. hyacinthus . The contents of carbohydrate and protein under continuous touching were decreased by 7 and 15% compared with the control group, respectively, causing negative growth. Under the dual influences of high ammonia nitrogen and continuous touching, all energy reserves were significantly lower. Repeated touching and sediment cover in diving areas containing high ammonia content increased the concentrations of lipid and protein compared with the touching and high nutrient treatment group likely because that Porites associated with C15 zooxanthella increased heterotrophic feeding to compensate for restricted symbiodiniaceae photosynthesis. Additionally, P. cylindrica produced mucus to aid the removal of sediment, so that corals didn’t obviously bleach during the experiment. Collectively, P. cylindrica was more resistant to diving activities than A. hyacinthus which only relies on photoautotrophy. To ensure the sustainable development of coral reef dive tourism, it is necessary to strengthen the supervision of diving behaviors, rotate the diving areas, and conduct regular assessments on the coral status.

The ATP Level in the mPFC Mediates the Antidepressant Effect of Calorie Restriction - Qian Wang; Ying Kong; Song Lin; Ding-Yu Wu; Jian Hu; Lang Huang; Wen-Si Zang; Xiao-Wen Li; Jian-Ming Yang; Tian-Ming Gao (Neuroscience Bulletin, 2021)

Degradation and chlorination mechanism of fumaric acid based on SO4•−: an experimental and theoretical study - Ying Huang; Xubiao Yu; Huihui Gan; Li Jiang; Hancheng Gong (Environmental Science and Pollution Research, 2021)

Biodegradation of Di-n-butyl phthalate in rhizosphere and growth-promoting effect of Cucumis sativus Linn. by a novel Pseudomonas sp. DNB-S1 - Shuqin Li; Lei Wang; Ying Li; Fuxin Huang; Hui Yu; Ying Zhang; Rui Li; Zhaobo Chen; Ningrui Wei; Zhengzhe Yu (Ecotoxicology, 2021)

Characterization, Sources and Excessive Cancer Risk of PM2.5-Bound Polycyclic Aromatic Hydrocarbons in Different Green Spaces in Lin’an, Hangzhou, China - Fang Huang; Yinke Zhang; Yilei Lou; Xiaolu Li; Tianran Zhang; Hui Yu; Chuyang Yuan; Qun Tong; Feng Qi; Feng Shao (Bulletin of Environmental Contamination and Toxicology, 2021)

Baicalin attenuates adriamycin-induced nephrotic syndrome by regulating fibrosis procession and inflammatory reaction - Ning Tan; Chen-Xia Sun; Hui-Jun Zhu; De-Yu Li; Sheng-Guang Huang; Shou-Di He (Genes & Genomics, 2021)

Functional characterization of TNF‐ α in pufferfish ( Takifugu obscurus ) in immune response and apoptosis against Aeromonas hydrophila - Linghe Kong; Kun Qian; Siwei Wu; Bingxi Li; Zheng Guo; Xiaoxue Yin; Yu Huang; Jianmin Ye; Xiao Tu; Shengli Fu (Journal of Fish Diseases, 2021)
Tumour necrosis factor‐ α (TNF‐ α ) is a multifunctional cytokine involved in immune system homeostasis, antimicrobial defence, regulation of apoptosis, cell proliferation and differentiation. Although the pro‐inflammatory property of TNF‐ α has been made new progress, detailed research on host defence against bacterial infection and inducing apoptosis remains to be revealed in early vertebrates. Here, we reported the TNF‐ α homologue (ToTNF‐ α ) from pufferfish ( Takifugu obscurus ). The open reading frame (ORF) of ToTNF‐α was 753 bp, encoding a protein of 250 aa contained the TNF family signature and conserved cysteine residues. The mRNA expression of ToTNF‐α had a wide range of tested tissues, with the highest expression in the skin. After Aeromonas hydrophila infection, the mRNA expression of ToTNF‐α was significantly up‐regulated both in vivo and in vitro experiments. After stimulation by recombinant protein of ToTNF‐ α ((r)ToTNF‐ α ), the relative expressions of endogenous TNF‐α , caspase 8 , caspase 3 , p53 , and Bax inhibitor‐1 in head kidney leucocytes were all notably up‐regulated. These results showed that ToTNF‐ α might induce apoptosis depend on pro‐ and anti‐apoptotic proteins at mRNA level. Moreover, flow cytometry analysis indicated that the (r)ToTNF‐ α can induce apoptosis of head kidney leucocytes. Taken together, these characteristics suggest that ToTNF‐α can participate in immune response against A. hydrophila and induce apoptosis at mRNA and cellular level, which will help to understand the mechanism of apoptosis and immune response in teleost fish.

Commensal bacteria‐immunity crosstalk shapes mucosal homeostasis in teleost fish - Yong‐Yao Yu; Li‐Guo Ding; Zhen‐Yu Huang; Hao‐Yue Xu; Zhen Xu (Reviews in Aquaculture, 2021)
Fish harbour complex and dynamic microbiota in their mucosal surfaces. Due to the vital role of commensal microbiota in many biological functions including growth enhancement, nutrition, development, metabolism and immune response, many scholars have begun to refer to the microbiome as an ‘extended self’. Several studies have indicated that a normal microbiota contributes to fish health, and disturbances in microbial communities may lead to secondary infections and disease. Under evolutionary selective forces, fish have developed excellent innate immune mechanisms and an adaptive immune system composed of B cells and T cells to discriminate between beneficial and opportunistic bacteria for microbiome homeostasis. Many functional studies have demonstrated the involvement of immune cells, cytokines and Igs in maintaining microbiome homeostasis, and many beneficial microbes contribute to improving the immune barrier against external threats. Additionally, many host‐derived probiotics have been empirically used in the aquaculture sector and have been demonstrated to provide effective protection against fish diseases. Although little is known about the interactions between microbiota and the mucosal immune system in fish compared to mammals, managing aquaculture system microbiota may represent a promising alternative to antibiotics for disease prevention and control. This review thus provides an updated and comprehensive summary of currently characterized microbe compositions in fish mucosal tissues. Thereafter, the current knowledge on the crosstalk between microbiota and the mucosal immune system and probiotics in application is also discussed herein, thereby providing a theoretical basis for the development of microbe‐based disease control technologies in aquaculture.

Anti-Inflammatory and anti-proliferative oleanane-type triterpene glycosides from the vine of Momordica cochinchinensis - Hung-Tse Huang; Yu-Chi Lin; Li-Jie Zhang; Chia-Ching Liaw; Hsin-Yen Chen; Ming-Tung Hsueh; Yao-Haur Kuo (Natural Product Research, 2021)

Wogonin Accelerates Hematoma Clearance and Improves Neurological Outcome via the PPAR-γ Pathway After Intracerebral Hemorrhage - Jianfeng Zhuang; Yucong Peng; Chi Gu; Huihui Chen; Zheng Lin; Hang Zhou; Xiao Wu; Jianru Li; Xiaobo Yu; Yang Cao; Hanhai Zeng; Xiongjie Fu; et al. (Translational Stroke Research, 2021)

The Protective A673T Mutation of Amyloid Precursor Protein (APP) in Alzheimer’s Disease - Qing Xia; XinYu Yang; JiaBin Shi; ZiJie Liu; YaHui Peng; WenJing Wang; BoWen Li; Yu Zhao; JiaYing Xiao; Lei Huang; DaYong Wang; Xu Gao (Molecular Neurobiology, 2021)

Seismic response characteristics and deformation evolution of the bedding rock slope using a large-scale shaking table - Jianxian He; Shengwen Qi; Zhifa Zhan; Songfeng Guo; Chunlei Li; Bowen Zheng; Xiaolin Huang; Yu Zou; Guoxiang Yang; Ning Liang (Landslides, 2021)

MiR-467a-5p aggravates myocardial infarction by modulating ZEB1 expression in mice - Wei Huang; Yu Cao; Chenyang Chen; Xi Wu; Zhe Sheng; Anying Li (Journal of Molecular Histology, 2021)

Psychological and occupational impact on healthcare workers and its associated factors during the COVID-19 outbreak in China - Xiaodan Zhang; Ye Jiang; Hu Yu; Yafen Jiang; Qiongfeng Guan; Weihe Zhao; Yingying Mao; Danfeng Huang; Wenke Hong; Da Li (International Archives of Occupational and Environmental Health, 2021)

Physiological responses involved in cadmium tolerance in a high-cadmium-accumulating rice (Oryza sativa L.) line - Huan Yang; Haiying Yu; Hao Tang; Huagang Huang; Xizhou Zhang; Zicheng Zheng; Yongdong Wang; Tingxuan Li (Environmental Science and Pollution Research, 2021)

Maternal exposure to sulfur dioxide and the risk of oral clefts in Liaoning Province, China: a population-based case-control study - Fang-Hua Liu; Ze Xing; Ting-Ting Gong; Jia-Yu Zhang; Yan-Hong Huang; Jing Li; Shu Liu; Yan-Ling Chen; Li-Li Li; Cheng-Zhi Jiang; Zong-Jiao Chen; Yu-Hong Zhao; et al. (Environmental Science and Pollution Research, 2021)

Flexible reconfiguration of functional brain networks as a potential neural mechanism of creativity - Junchao Li; Natasza Orlov; Zengjian Wang; Bingqing Jiao; Yibo Wang; Huawei Xu; Hui Yang; Yingying Huang; Yan Sun; Peng Zhang; Rengui Yu; Ming Liu; et al. (Brain Imaging and Behavior, 2021)

Abnormal white matter tracts of insula in smokers - Chao Wang; Shuyue Wang; Peiyu Huang; Zhujing Shen; Wei Qian; Xiao Luo; Kaicheng Li; Qingze Zeng; Quanquan Gu; Hualiang Yu; Yihong Yang; Minming Zhang (Brain Imaging and Behavior, 2021)

OSL chronology of a Palaeolithic site in a humid subtropical mountainous area of southeast China - Jian-hui Jin; Xiao-yang Wang; Zhen-yu Zhou; Yun-ming Huang; Xue-chun Fan; Xin-xin Zuo; Zhi-zhong Li; Zhi-yong Ling; Yong-qing Ren; Shu-tong Li (Journal of Mountain Science, 2021)

Comparison of the Digestion and Absorption Characteristics of Docosahexaenoic Acid-Acylated Astaxanthin Monoester and Diester in Mice - Ye Li; Jie Yu; Jie Xu; Hongxia Che; Yuming Wang; Changhu Xue; Qingrong Huang; Tiantian Zhang (Journal of Ocean University of China, 2021)

Paracoccus binzhouensis sp. nov., isolated from activated sludge - Fang Wang; Xiao-Fan Gong; Dong Meng; Yu-Ling Liu; Peng-Fei Gu; Xiang-Yu Fan; Zhao-Song Huang; Zong-Jun Du; Qiang Li (Archives of Microbiology, 2021)

Aquiflexum lacus sp. nov., isolated from a lake sediment sample - Jianrong Huang; Mingxian Han; Baozhu Fang; Jian Yang; Haiyi Xiao; Xiying Zhang; Jibin Han; Dongmei Yu; Hongchen Jiang; Wenjun Li (Archives of Microbiology, 2021)

RSF1 requires CEBP/β and hSNF2H to promote IL-1β-mediated angiogenesis: the clinical and therapeutic relevance of RSF1 overexpression and amplification in myxofibrosarcomas - Chien-Feng Li; Ti-Chen Chan; Cheng-I. Wang; Fu-Min Fang; Po-Chun Lin; Shih-Chen Yu; Hsuan-Ying Huang (Angiogenesis, 2021)

Improving rice eating and cooking quality by coordinated expression of the major starch synthesis-related genes, SSII and Wx, in endosperm - Lichun Huang; Zhengwen Gu; Zhuanzhuan Chen; Jiawen Yu; Rui Chu; Hongyan Tan; Dongsheng Zhao; Xiaolei Fan; Changquan Zhang; Qianfeng Li; Qiaoquan Liu (Plant Molecular Biology, 2021)

Predicting gene phenotype by multi-label multi-class model based on essential functional features - Lei Chen; Zhandong Li; Tao Zeng; Yu-Hang Zhang; Hao Li; Tao Huang; Yu-Dong Cai (Molecular Genetics and Genomics, 2021)

On the nonlinear relationship between energy consumption and economic and social development: evidence from Henan Province, China - Fangzhao Deng; Hujun Li; Meng Yang; Wenjie Zhao; Zhiqiang Gai; Yunxia Guo; Jingwen Huang; Yu Hao; Haitao Wu (Environmental Science and Pollution Research, 2021)

Heavy Metals in Indoor Dust Across China: Occurrence, Sources and Health Risk Assessment - Baolin Liu; Fei Huang; Yong Yu; Xuedong Li; Yaowei He; Lei Gao; Xin Hu (Archives of Environmental Contamination and Toxicology, 2021)

Analysis of unigenes involved in lateral root development in Bupleurum chinense and B. scorzonerifolium - Ma Yu; Hua Chen; Qian Liu; Jing Huang; Kassa Semagn; Dan Liu; Yuchan Li; Bin Yang; Yilian He; Chun Sui; Dabin Hou; Jianhe Wei (Planta, 2021)

Genetic Architecture of Childhood Kidney and Urological Diseases in China - Ye Fang; Hua Shi; Tianchao Xiang; Jiaojiao Liu; Jialu Liu; Xiaoshan Tang; Xiaoyan Fang; Jing Chen; Yihui Zhai; Qian Shen; Guomin Li; Li Sun; et al. (Phenomics, 2021)
Kidney disease is manifested in a wide variety of phenotypes, many of which have an important hereditary component. To delineate the genotypic and phenotypic spectrum of pediatric nephropathy, a multicenter registration system is being implemented based on the Chinese Children Genetic Kidney Disease Database (CCGKDD). In this study, all the patients with kidney and urological diseases were recruited from 2014 to 2020. Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features. The genetic diagnosis was confirmed in 883 of 2256 (39.1%) patients from 23 provinces in China. Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome (SRNS, 23.5%), glomerulonephritis (GN, 32.2%), congenital anomalies of the kidney and urinary tract (CAKUT, 21.2%), cystic renal disease (3.9%), renal calcinosis/stone (3.6%), tubulopathy (9.7%), and chronic kidney disease of unknown etiology (CKDu, 5.8%). The pathogenic variants of 105 monogenetic disorders were identified. Ten distinct genomic disorders were identified as pathogenic copy number variants (CNVs) in 11 patients. The diagnostic yield differed by subgroups, and was highest in those with cystic renal disease (66.3%), followed by tubulopathy (58.4%), GN (57.7%), CKDu (43.5%), SRNS (29.2%), renal calcinosis /stone (29.3%) and CAKUT (8.6%). Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions. We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed. Our data demonstrate the utility of family-based exome sequencing, and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease.

Altered structural and functional connectivity in CSF1R-related leukoencephalopathy - Fei-Xia Zhan; Ze-Yu Zhu; Qing Liu; Hai-Yan Zhou; Xing-Hua Luan; Xiao-Jun Huang; Xiao-Li Liu; Wo-Tu Tian; Shi-Ge Wang; Xiao-Xuan Song; Guang Chen; Ming-Liang Zhao; et al. (Brain Imaging and Behavior, 2021)

Generation and identification of endothelial-specific Hrh2 knockout mice - Rui Meng; Wen-Ke Cai; Wen-Mang Xu; Qiang Feng; Ping Wang; Yan-hua Huang; Yu-Xin Fan; Tao Zhou; Qin Yang; Zhi-Ran Li; Gong-Hao He (Transgenic Research, 2021)

Paeoniflorin reduces the inflammatory response of THP-1 cells by up‐regulating microRNA-124 - Danyun Huang; Zhijun Li; Yue Chen; Yan Fan; Tao Yu (Genes & Genomics, 2021)
Background The activation of macrophages and the release of inflammatory cytokines are the main reasons for the progress of systemic lupus erythematosus (SLE). MicroRNA (miRNA)-124 is involved in the regulation of macrophages and is a key regulator of inflammation and immunity. Objective To explore whether paeoniflorin (PF) regulates the biological functions of macrophages depends on miR-124. Methods RT-PCR, WB, ELISA, CCK-8 and flow cytometry were used to evaluate that PF regulated the biological functions of THP-1 cells through miR-124. Results PF significantly inhibited the proliferation while promotes the apoptosis of THP-1 cells, and inhibited the release of IL-6, TNF-α and IL-1βin THP-1 cells. RT-PCR results shown that PF up-regulated the expression of miR-124 in THP-1 cells. Functional recovery experiments showed that compared with the LPS + mimic-NC group, LPS + miR-124 mimic significantly inhibited the proliferation and the release of IL-6, TNF-α and IL-1β, but promoted the apoptosis of THP-1 cells. In addition, compared with the LPS + PF + inhibitor-NC group, LPS + PF + miR-124 inhibitor significantly promoted the proliferation and the release of IL-6, TNF-α and IL-1β, but inhibited the apoptosis of THP-1 cells. Conclusions By down-regulating miR-124, PF inhibits the proliferation and inflammation of THP-1 cells, and promotes the apoptosis of THP-1 cells.

Vegetation Phenology in Permafrost Regions of Northeastern China Based on MODIS and Solar-induced Chlorophyll Fluorescence - Lixiang Wen; Meng Guo; Shuai Yin; Shubo Huang; Xingli Li; Fangbing Yu (Chinese Geographical Science, 2021)

Calculation of the safety thickness of water inrush with tunnel axis orthogonal to fault - Helin Fu; Pengtao An; Guowen Cheng; Jie Li; Zhen Huang; Xiaohui Yu (Arabian Journal of Geosciences, 2021)

Variations of carbon allocation and turnover time across tropical forests - Hui Yang; Philippe Ciais; Yilong Wang; Yuanyuan Huang; Jean‐Pierre Wigneron; Ana Bastos; Jérôme Chave; Jinfeng Chang; Christopher E. Doughty; Lei Fan; Daniel Goll; Emilie Joetzjer; et al. (Global Ecology and Biogeography, 2021)
Aim The carbon sink in tropical forests is a highly uncertain component of the global carbon budget. An understanding of the processes controlling this sink requires better quantification of carbon allocation, stocks and turnover times. Location Tropical forests. Time period 2010–2017. Major taxa studied Tropical forest ecosystem. Methods We develop a novel data assimilation system using satellite‐based annual above‐ground biomass derived from L‐band vegetation optical depth with 25 km × 25 km grid spacing, together with leaf area, to constrain the 25 km × 25 km carbon allocation patterns of net primary productivity (NPP) into the wood, leaf and root pools, and their turnover times. Our average data‐driven estimates of these variables are broadly consistent with independent ground‐based estimates of NPP allocation and wood turnover from forest inventory plots. Results In tropical forest, on average, the NPP allocation into wood (0.30 ± 0.04) is significantly higher than that into leaves (0.24 ± 0.07). From the wet to dry tropics, forest NPP allocation into both wood and leaves declines slightly. The turnover times of forest leaf pools exhibit little spatial variation, whereas the turnover times of wood pools in Africa (median and interquartile range: years) are slightly longer than those in South America ( years) and Southeast Asia ( years). Our datasets reveal emergent trade‐offs across climatic and vegetation gradients between growth and life span/turnover for both wood and leaves. The spatial gradients of NPP allocation to wood/leaves are associated with canopy height, adjusted by climate condition and nutrient acquisition. The spatial gradients of wood and leaf turnover times are influenced mainly by climate and leaf characteristics. Main conclusions Our data‐driven estimates of carbon allocation and turnover times provide a basis for more detailed exploration of these mechanisms in field studies. This highlights that improved model representation of carbon allocation and turnover is necessary for more accurate prediction of future carbon dynamics.

Design of supercontinuum laser hyperspectral light detection and ranging (LiDAR) (SCLaHS LiDAR) - Guoqing Zhou; Xiang Zhou; Youjian Song; Donghui Xie; Long Wang; Guangjian Yan; Minglie Hu; Bowen Liu; Weidong Shang; Chenghu Gong; Cheng Wang; Huaguo Huang; et al. (International Journal of Remote Sensing, 2021)

Emergence and prevalence of naturally occurring lower virulent African swine fever viruses in domestic pigs in China in 2020 - Encheng Sun; Zhenjiang Zhang; Zilong Wang; Xijun He; Xianfeng Zhang; Lulu Wang; Wenqing Wang; Lianyu Huang; Fei Xi; Haoyue Huangfu; Ghebremedhin Tsegay; Hong Huo; et al. (Science China Life Sciences, 2021)

Prediction model based on the Laplacian eigenmap method combined with a random forest algorithm for rainstorm satellite images during the first annual rainy season in South China - Xiao-yan Huang; Li He; Hua-sheng Zhao; Ying Huang; Yu-shuang Wu (Natural Hazards, 2021)

MiR-124 and Small Molecules Synergistically Regulate the Generation of Neuronal Cells from Rat Cortical Reactive Astrocytes - Yangyang Zheng; Zhehao Huang; Jinying Xu; Kun Hou; Yifei Yu; Shuang Lv; Lin Chen; Yulin Li; Chengshi Quan; Guangfan Chi (Molecular Neurobiology, 2021)

Synthesis and antitumor evaluation of (aryl)methyl-amine derivatives of dehydroabietic acid-based B ring-fused-thiazole as potential PI3K/AKT/mTOR signaling pathway inhibitors - Nai-Yuan Chen; Yu-Lan Xie; Guo-Dong Lu; Fang Ye; Xin-Yu Li; Yu-Wen Huang; Ming-Li Huang; Tie-Yu Chen; Cui-Ping Li (Molecular Diversity, 2021)

A Xanthene Dye‐based Sensor for Viscosity and Cell Imaging - Bo Yu; Ying Zhou; Lihua Dou; Yunyun Li; Zhengwen Huang (Journal of Fluorescence, 2021)

Occurrence, sources and fate of pharmaceuticals and personal care products and artificial sweeteners in groundwater - Zhiping Li; Xiaopeng Yu; Furong Yu; Xin Huang (Environmental Science and Pollution Research, 2021)

The regulatory role of root in cadmium accumulation in a high cadmium-accumulating rice line (Oryza sativa L.) - Haiying Yu; Keji Wang; Huagang Huang; Xizhou Zhang; Tingxuan Li (Environmental Science and Pollution Research, 2021)

Short-term offshore extension of Brahmaputra-Ganges and Irrawaddy freshwater plumes to the central northern Bay of Bengal based on in situ and satellite observations - Zhiyuan Li; Saihua Huang; Xiaohua Zhu; Zhilin Sun; Yu Long; Huawei Xie (Acta Oceanologica Sinica, 2021)

Rapid Modeling of the Sound Speed Field in the South China Sea Based on a Comprehensive Optimal LM-BP Artificial Neural Network - Jin Huang; Yu Luo; Jian Shi; Xin Ma; Qian-Qian Li; Yan-Yi Li (Journal of Marine Science and Engineering, 2021)
Ocean sound speed is an essential foundation for marine scientific research and marine engineering applications. In this article, a model based on a comprehensive optimal back propagation artificial neural network model is developed. The Levenberg–Marquardt algorithm is used to optimize the model, and the momentum term, normalization, and early termination method were used to predict the high precision marine sound speed profile. The sound speed profile was described by five indicators: date, time, latitude, longitude, and depth. The model used data from the CTD observation dataset of scientific investigation over the South China Sea (2009–2012) (108°–120° E, 6°–8° N), which includes comprehensive scientific investigation data from four voyages. The feasibility of modeling the sound speed field in the South China Sea is investigated. The proposed model uses the momentum term, normalization, and early termination in a traditional BP artificial neural network structure and mitigates issues with overtraining and difficulty when determining the BP neural network parameters. With the LM algorithm, a fast-modeling method for the sound field effectively achieves the precision requirement for sound speed prediction. Through the prediction and verification of the data from 2009 to 2012, the newly proposed optimized BP network model is shown to dramatically reduce the training time and improve precision compared to the traditional network model. Results showed that the root mean squared error decreased from 1.7903 m/s to 0.95732 m/s, and the training time decreased from 612.43 s to 4.231 s. Finally, the sound ray tracing simulations confirm that the model meets the accuracy requirements of acoustic sounding and verify the model’s feasibility for the real-time prediction of the vertical sound speed in saltwater bodies.

Mortality burden caused by diurnal temperature range: a nationwide time-series study in 364 Chinese locations - Min Cai; Jianxiong Hu; Chunliang Zhou; Zhulin Hou; Yanjun Xu; Maigeng Zhou; Yize Xiao; Biao Huang; Xiaojun Xu; Lifeng Lin; Tao Liu; Jianpeng Xiao; et al. (Stochastic Environmental Research and Risk Assessment, 2021)

Dynamic modelling and motion control research on deep seabed miner - Yu Dai; Xuyang Li; Wanwu Yin; Liping Pang; Ya Xie; Zhonghua Huang (Marine Georesources & Geotechnology, 2021)

Dynamics analysis of deep-sea mining pipeline system considering both internal and external flow - Yu Dai; Xuyang Li; Wanwu Yin; Zhonghua Huang; Ya Xie (Marine Georesources & Geotechnology, 2021)

Human β-Defensin 118 Attenuates Escherichia coli K88–Induced Inflammation and Intestinal Injury in Mice - Qian Lin; Qingqing Fu; Xiang Li; Yuheng Luo; Junqiu Luo; Daiwen Chen; Xiangbing Mao; Bing Yu; Ping Zheng; Zhiqing Huang; Jie Yu; Hui Yan; et al. (Probiotics and Antimicrobial Proteins, 2021)

GTree: an Open-source Tool for Dense Reconstruction of Brain-wide Neuronal Population - Hang Zhou; Shiwei Li; Anan Li; Qing Huang; Feng Xiong; Ning Li; Jiacheng Han; Hongtao Kang; Yijun Chen; Yun Li; Huimin Lin; Yu-Hui Zhang; et al. (Neuroinformatics, 2021)

The Roles of Epinephelus coioides miR-122 in SGIV Infection and Replication - Hong-Yan Sun; Yu-Ling Su; Pin-Hong Li; Jia-Yang He; He-Jia Chen; Gang Wang; Shao-Wen Wang; Xiao-Hong Huang; You-Hua Huang; Qi-Wei Qin (Marine Biotechnology, 2021)
In mammals, mature miR-122 is 22 nucleotides long and can be involved in regulating a variety of physiological and biological pathways. In this study, the expression profile and effects of grouper Epinephelus coioides miR-122 response to Singapore grouper iridovirus (SGIV) infection were investigated. The sequences of mature microRNAs (miRNAs) from different organisms are highly conserved, and miR-122 from E. coioides exhibits high similarity to that from mammals and other fish. The expression of miR-122 was up-regulated during SGIV infection. Up-regulation of miR-122 could significantly enhance the cytopathic effects (CPE) induced by SGIV, the transcription levels of viral genes (MCP, VP19, LITAF and ICP18), and viral replication; reduce the expression of inflammatory factors (TNF-a, IL-6, and IL-8), and the activity of AP-1 and NF-κB, and miR-122 can bind the target gene p38α MAPK to regulate the SGIV-induced cell apoptosis and the protease activity of caspase-3. The results indicated that SGIV infection can up-regulate the expression of E. coioides miR-122, and up-regulation of miR-122 can affect the activation of inflammatory factors, the activity of AP-1 and NF-κB, and cell apoptosis to regulate viral replication and proliferation.

Identification and characterization of CONSTANS-like genes from Curcuma alismatifolia - Yuan-Yuan Li; Xiao-Huang Chen; Hui-Wen Yu; Qi-Lin Tian; Luan-Mei Lu (Horticulture, Environment, and Biotechnology, 2021)

Rescue effects of Se-enriched rice on physiological and biochemical characteristics in cadmium poisoning mice - Yang Su; Ling Li; Muhammad Umer Farooq; Xin Huang; Tengda Zheng; Yu Jie Zhang; Hla Hla Ei; Faiz Hussain Panhwar; Zhichen Tang; Rui Zeng; Yuanke Liang; Xiaoying Ye; et al. (Environmental Science and Pollution Research, 2021)

Chelativorans alearense sp. nov., A Novel Bacterial Species Isolated From Soil in Alear, China - Dong Meng; Yu-Ling Liu; Peng-Fei Gu; Xiang-Yu Fan; Zhao-Song Huang; Yan Ji; Wei-Min Li; Zong-Jun Du; Qiang Li (Current Microbiology, 2021)

Decomposition of projected summer rainfall change over East Asia based on timeslice experiments - Yu Huang; Hong-Li Ren; Robin Chadwick; Yi Deng (Climate Dynamics, 2021)

Perinatal Lead Exposure Alters Calsyntenin-2 and Calsyntenin-3 Expression in the Hippocampus and Causes Learning Deficits in Mice Post-weaning - Ning Li; Shuai Cao; Zengli Yu; Mingwu Qiao; Yongxia Cheng; Yue Shen; Lianjun Song; Xianqing Huang; Guojun Yang; Yali Zhao (Biological Trace Element Research, 2021)

Groundwater sources, flow patterns, and hydrochemistry of the Central Yinchuan Plain, China - Ying Li; Ping Wu; Xiao-Qin Huang; Bo Zhang; Zhao-Xiang Xu; Yang Li; Jie Li; Lu-Chen Wang; Yu-Fang Sun; Xu-Chen Meng; Cheng-Wen Wang; Zi-Zhao Cai (Hydrogeology Journal, 2021)

Maternal exposure to ambient SO2 and risk of polydactyly and syndactyly: a population-based case-control study in Liaoning Province, China - Yu-Ting Jiang; Ting-Ting Gong; Jia-Yu Zhang; Yan-Hong Huang; Jing Li; Shu Liu; Yan-Ling Chen; Li-Li Li; Cheng-Zhi Jiang; Zong-Jiao Chen; Yu-Hong Zhao; Qi-Jun Wu (Environmental Science and Pollution Research, 2021)

The potential association between Wolbachia infection and DNA methylation in Hylyphantes graminicola (Araneae: Linyphiidae) - Abulimiti Abudukadier; Xuan Huang; Ya-qi Peng; Fan Zhang; Hao Liu; Jian Chen; Yue-li Yun; Yu Peng (Symbiosis, 2021)

Chelativorans xinjiangense sp. nov., a novel bacterial species isolated from soil in Xinjiang, China - Dong Meng; Yu-Ling Liu; Peng-Fei Gu; Xiang-Yu Fan; Zhao-Song Huang; Yan Ji; Wei-Min Li; Zong-Jun Du; Qiang Li (Archives of Microbiology, 2021)

Nanomaterials for Airborne Virus Inactivation: A Short Review - Rong Li; Long Cui; Meijuan Chen; Yu Huang (Aerosol Science and Engineering, 2021)

Allometric growth and carbon storage in the mangrove Sonneratia apetala - Dehuang Zhu; Dafeng Hui; Mengqi Wang; Qiong Yang; Zhen Li; Zijian Huang; Hanmeng Yuan; Shixiao Yu (Wetlands Ecology and Management, 2021)

Cardiac Na+-Ca2+ exchanger 1 (ncx1h) is critical for the ventricular cardiomyocyte formation via regulating the expression levels of gata4 and hand2 in zebrafish - Liming Chu; Huimin Yin; Lei Gao; Li Gao; Yu Xia; Chiyuan Zhang; Yi Chen; Tingxi Liu; Jijun Huang; Kenneth R. Boheler; Yong Zhou; Huang-Tian Yang (Science China Life Sciences, 2021)

Molecular Regulatory Mechanism and Toxicology of Neurodegenerative Processes in MPTP/Probenecid-Induced Progressive Parkinson’s Disease Mice Model Revealed by Transcriptome - Weiwei Yang; Wenwen Hao; Zhuo Meng; Shiyan Ding; Xiaodi Li; Tao Zhang; Weixiao Huang; Lian Xu; Yu Zhang; Jian Yang; Xiaosong Gu (Molecular Neurobiology, 2021)
Parkinson’s disease (PD) is a neurodegenerative disease caused by a variety of unclear complex pathogenic factors. The 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine/probenecid (MPTP/p)-induced progressive PD mice is a well-recognized classic model for studying PD, but the molecular toxicology of this model is still unclear. Here, for the first time, we report gradual neurodegenerative processes in MPTP/p-induced progressive PD mice model using RNA-seq. Transcriptional responses are orchestrated to regulate the expression of many genes in substantia nigra, such as Ntf3 , Pitx3 , Th , and Drd2 , leading to the degeneration of dopaminergic neurons at last. We proposed that the established model could be divided into three phases based on their molecular toxicological features: “the stress response phase” which maintained the microenvironment homeostasis, “the pre-neurodegenerative phase” which demonstrated observed MPTP/p cytotoxicity and gradual degeneration of dopaminergic neurons, and “the neurodegenerative phase” which reflected distinct damage and dopaminergic neuron apoptotic process. Glia cells exhibited a certain protective effect on dopaminergic neurons in 3rd and 6th MPTP/p-induced cytotoxicity. But in 10th MPTP/p injection, glia cells play a promoting role in PD and tissue damages caused by oxidative stress. This study also indicated that the substantia nigra of PD mice showed unique patterns of changes at each stage. Moreover, neurotrophic signaling pathway, ECM-receptor interaction, oxidative phosphorylation, apoptosis and necroptosis were enriched at 3rd and 6th MPTP/p injection, which might be associated with the PD progress. This study provided an extensive data set of molecular toxicology for elucidating of PD progression and offered comprehensive theoretical knowledge for the development of new therapy.

Reclamation substantially increases soil organic and inorganic carbon stock in riparian floodplains - Cuicui Hou; Yingchen Li; Yanwei Huang; Honglei Zhu; Jianmin Ma; Fei Yu; Xinhou Zhang (Journal of Soils and Sediments, 2021)

Clinical Efficacy of a New Robot-assisted Gait Training System for Acute Stroke Patients - Andy Chien; Fei-Chun Chang; Nai-Hsin Meng; Pei-Yu Yang; Ching Huang; Li-Wei Chou (Journal of Medical and Biological Engineering, 2021)
Purpose Robot-assisted gait rehabilitation has been proposed as a plausible supplementary rehabilitation strategy in stroke rehabilitation in the last decade. However, its exact benefit over traditional rehabilitation remain sparse and unclear. It is therefore the purpose of the current study to comparatively investigate the clinical benefits of the additional robot-assisted training in acute stroke patients compared to standard hospital rehabilitation alone. Methods Ninety acute stroke patients (< 3 month) were recruited. All participants received the standard hospital neurorehabilitation comprises 45–60 min sessions daily for 3 weeks. Sixty patients also received an additional 30 min of robot-assisted gait training with the HIWIN MRG-P100 gait training system after each of the standard neurorehabilitation session. Outcome measures included: 1. Berg Balance Scale (BBS); 2. Brunnstrom Stage; 3. Pittsburgh Sleep Quality Index and 4. Taiwanese Depression Questionnaire (TDQ) which were assessed pre-treatment and then after every five training sessions. Results Both groups demonstrated significant improvement pre- and post-treatment for the BBS (robotic group p = 0.023; control group p = 0.033) but no significant difference (p > 0.1) between the groups were found. However, the robotic training group had more participants demonstrating larger BBS points of improvement as well as greater Brunnstrom stage of improvement, when compared to the control group. No significant within and between group statistical differences (p > 0.3) were found for Pittsburgh Sleep Quality Index and Taiwanese Depression Questionnaire. Conclusion The addition of robotic gait training on top of standard hospital neurorehabilitation for acute stroke patients appear to produce a slightly greater improvement in clinical functional outcomes, which is not transferred to psychological status.

Association between selected urinary heavy metals and asthma in adults: a retrospective cross-sectional study of the US National Health and Nutrition Examination Survey - Xiuzhu Li; Yun Fan; Yan Zhang; Xiaomin Huang; Zhenyao Huang; Mingming Yu; Qiaoqiao Xu; Xiumei Han; Chuncheng Lu; Xinru Wang (Environmental Science and Pollution Research, 2021)

Risks Assessment Associated with Different Sources of Metals in Abandoned Soil of Zhuxianzhuang Coal Mine, Huaibei Coalfield (Anhui, China) - Hongxia Fang; Herong Gui; Jun Li; Hao Yu; Meichen Wang; Yaqi Jiang; Chunlei Wang; Chen Chen; Yaru Zhang; Yiheng Huang (Bulletin of Environmental Contamination and Toxicology, 2021)

Low-Dose Ozone Therapy Improves Sleep Quality in Patients with Insomnia and Coronary Heart Disease by Elevating Serum BDNF and GABA - Y. Li; X. Feng; H. Ren; H. Huang; Yu. Wang; S. Yu (Bulletin of Experimental Biology and Medicine, 2021)

Modes of genetic adaptations underlying functional innovations in the rumen - Xiangyu Pan; Yudong Cai; Zongjun Li; Xianqing Chen; Rasmus Heller; Nini Wang; Yu Wang; Chen Zhao; Yong Wang; Han Xu; Songhai Li; Ming Li; et al. (Science China Life Sciences, 2021)

Nitrate leaching losses mitigated with intercropping of deep-rooted and shallow-rooted plants - Yu Ding; Xing Huang; Yong Li; Haiyang Liu; Qichun Zhang; Xingmei Liu; Jianming Xu; Hongjie Di (Journal of Soils and Sediments, 2021)

The roles of collagen in chronic kidney disease and vascular calcification - Aoran Huang; Guangying Guo; Yanqiu Yu; Li Yao (Journal of Molecular Medicine, 2021)

MiRNA-seq analysis of spleen and head kidney tissue from aquacultured largemouth bass (Micropterus salmoides) in response to Aeromonas hydrophila infection - Jian Zhou; Han Zhao; Lu Zhang; Qiang Li; Zhipeng Huang; Zhongmeng Zhao; Hongyu Ke; Yu Xiao; Xutao Su; Qiao Liu; Song Yang; Liulan Zhao (Functional & Integrative Genomics, 2021)

Fast and reversible adsorption for dibenzothiophene in fuel oils with metallic nano-copper supported on mesoporous silica - Xinsheng Li; Shuo Ai; Yongchun Huang; Chengdu Huang; Wanguo Yu; Zhijuan Mao (Environmental Science and Pollution Research, 2021)

Structural and functional brain signatures of endurance runners - Long Cao; Yuanchao Zhang; Ruiwang Huang; Lunxiong Li; Fengguang Xia; Liye Zou; Qian Yu; Jingyuan Lin; Fabian Herold; Stephane Perrey; Patrick Mueller; Milos Dordevic; et al. (Brain Structure and Function, 2021)

Paenibacillus turpanensis sp. nov., isolated from a salt lake of Turpan city in Xinjiang province, north-west China - Li Yang; Hua-Wei Huang; Yun Wang; Ya-Rong Kou; Min Yin; Yu Li; Xue-Qian Wang; Gui-Fang Zhao; Wen-Yong Zhu; Shu-Kun Tang (Archives of Microbiology, 2021)

Profiles and Source Apportionment of Nonmethane Volatile Organic Compounds in Winter and Summer in Xi’an, China, based on the Hybrid Environmental Receptor Model - Jian Sun; Zhenxing Shen; Yue Zhang; Wenting Dai; Kun He; Hongmei Xu; Zhou Zhang; Long Cui; Xuxiang Li; Yu Huang; Junji Cao (Advances in Atmospheric Sciences, 2021)

Three new andrastin derivatives from the endophytic fungus Penicillium vulpinum - Yu-Yue Qin; Xi-Shan Huang; Xiao-Bo Liu; Tu-Xiang Mo; Zhao-Long Xu; Ben-Chao Li; Xiao-Ya Qin; Jun Li; Till F. Schӓberle; Rui-Yun Yang (Natural Product Research, 2020)

Exploring difference in land surface temperature between the city centres and urban expansion areas of China’s major cities - Jiyao Zhao; Le Yu; Yidi Xu; Xuecao Li; Yuyu Zhou; Dailiang Peng; Han Liu; Xiaomeng Huang; Zheng Zhou; Dong Wang; Chao Ren; Peng Gong (International Journal of Remote Sensing, 2020)

The Arabidopsis KH-domain protein FLOWERING LOCUS Y delays flowering by upregulating FLOWERING LOCUS C family members - Guang-Yi Dai; Ding-Kang Chen; Yun-Peng Sun; Wei-Yi Liang; Yu Liu; Li-Qun Huang; Yong-Kang Li; Jia-Fan He; Nan Yao (Plant Cell Reports, 2020)

Enrichment of cadmium in rice (Oryza sativa L.) grown under different exogenous pollution sources - Yi-Min Zhou; Si-Si Long; Bing-Yu Li; Ya-Yuan Huang; Yong-Jie Li; Jia-Yan Yu; Hui-Hui Du; Sardar Khan; Ming Lei (Environmental Science and Pollution Research, 2020)

Psychological symptoms in Chinese nurses may be associated with predisposition to chronic disease: a cross-sectional study of suboptimal health status - Jinxiu Zhu; Wenjuan Ying; Li Zhang; Gangyi Peng; Weiju Chen; Enoch Odame Anto; Xueqing Wang; Nan Lu; Shanshan Gao; Guihai Wu; Jingyi Yan; Jianfeng Ye; et al. (EPMA Journal, 2020)
Background Suboptimal health status (SHS) is a reversible state between ideal health and illness and it can be effectively reversed by risk prediction, disease prevention, and personalized medicine under the global background of predictive, preventive, and personalized medicine (PPPM) concepts. More and more Chinese nurses have been troubled by psychological symptoms (PS). The correlation between PS and SHS is unclear in nurses. The purpose of current study is to investigate the prevalence of SHS and PS in Chinese nurses and the relationship between SHS and PS along with predisposing factors as well as to discuss the feasibility of improving health status and preventing diseases according to PPPM concepts in Chinese nurses. Methods A cross-sectional study was conducted with the cluster sampling method among 9793 registered nurses in Foshan city, China. SHS was evaluated with the Suboptimal Health Status Questionnaire-25 (SHSQ-25). Meanwhile, the PS of depression and anxiety were evaluated with Self-Rating Depression Scale (SDS) and Self-Rating Anxiety Scale (SAS) self-assessment questionnaires. The relationship between PS and SHS in Chinese nurses was subsequently analyzed. Results Among the 9793 participants, 6107 nurses were included in the final analysis. The prevalence of SHS in the participants was 74.21% (4532/6107) while the symptoms of depression and anxiety were 47.62% (2908/6107) and 24.59% (1502/6107) respectively. The prevalence of SHS in the participants with depression and anxiety was significantly higher than those without the symptoms of depression (83.3% vs 16.7%, P < 0.001) and anxiety (94.2% vs 5.8%, P < 0.0001). The ratio of exercise habit was significantly lower than that of non-exercise habit (68.8% vs 78.4%, P < 0.001) in SHS group. Conclusions There is a high prevalence of SHS and PS in Chinese nurses. PS in Chinese nurses are associated with SHS. Physical exercise is a protective factor for SHS and PS so that the exercise should be strongly recommended as a valuable preventive measure well in the agreement with PPPM philosophy. Along with SDS and SAS, SHSQ-25 should also be highly recommended and applied as a novel predictive/preventive tool for the health measures from the perspectives of PPPM in view of susceptible population and individual screening, the predisposition to chronic disease preventing, personalization of intervention, and the ideal health state restoring.

Deformation and failure of a high-steep slope induced by multi-layer coal mining - Jian-le Yu; Jian-jun Zhao; Hao-yuan Yan; Qi-yi Lai; Run-qiu Huang; Xiu-wei Liu; Yang-chnn Li (Journal of Mountain Science, 2020)

TIAM1 Upregulation Confers NVP-BEZ235 Resistance to Breast Cancer Cells Through FGFR/STAT3 Pathway - Jingjing Qiao; Man Li; Na Li; Lingzhi Xu; Gena Huang; Jing Yu (Biochemical Genetics, 2020)

Modeling of CHAMP satellite data according to the 3D surface spline model of geomagnetic fields - Yan Feng; Huang Ya; Liu Shuang; Li Yu-jun; Jiang Yi (Applied Geophysics, 2020)

Mechanical Properties and Failure Behavior of Dry and Water-Saturated Anisotropic Coal Under True-Triaxial Loading Conditions - Yubing Liu; Guangzhi Yin; Minghui Li; Dongming Zhang; Gun Huang; Peng Liu; Chao Liu; Honggang Zhao; Beichen Yu (Rock Mechanics and Rock Engineering, 2020)

The effect of blastomere loss during frozen embryo transfer on the transcriptome of offspring’s umbilical cord blood - Yan-Ting Wu; Ze-Han Dong; Cheng Li; Dai-Zhan Zhou; Jun-Yu Zhang; Yan Wu; Jing-Jing Xu; Yu Wang; Xiao-Qun Ye; Jian-Zhong Sheng; Li Wang; He-Feng Huang (Molecular Biology Reports, 2020)

Design and synthesis of novel spirooxindole–indenoquinoxaline derivatives as novel tryptophanyl-tRNA synthetase inhibitors - Wen Ren; Qian Zhao; Meng Yu; Li Guo; Hongmei Chang; Xian Jiang; Youfu Luo; Wei Huang; Gu He (Molecular Diversity, 2020)

Metabolic diversification of anaerobic methanotrophic archaea in a deep-sea cold seep - Wen-Li Li; Yu-Zhi Wu; Guo-wei Zhou; Hui Huang; Yong Wang (Marine Life Science & Technology, 2020)
Anaerobic methanotrophic archaea (ANME) can assimilate methane and govern the greenhouse effect of deep-sea cold seeps. In this study, a total of 13 ANME draft genomes representing five ANME types (ANME-1a, ANME-1b, ANME-2a, ANME-2b and ANME-2c), in size between 0.8 and 1.8 Mbp, were obtained from the Jiaolong cold seep in the South China Sea. The small metagenome-assembled genomes (MAGs) contained all the essential pathways for methane oxidization and carbon dioxide fixation. All genes related to nitrate and sulfate reduction were absent from the MAGs, indicating their syntrophic dependence on partner organisms. Aside from acetate secretion and sugar storage, propanoate synthesis pathway, as an alternative novel carbon flow, was identified in all the MAGs and transcriptionally active. Regarding type-specific features of the MAGs, the genes encoding archaellum and bacteria-derived chemotaxis were specific to ANME-2, perhaps for fitness under fluctuation of methane and sulfate concentration flux. Our genomic and transcriptomic results strongly suggested that ANME could carry out simple carbon metabolism from C1 assimilation to C3 biosynthesis in the SCS cold seep, which casts light on a novel approach for synthetic biology.

Paddy soil nutrients and stoichiometric ratios as affected by anthropogenic activities during long-term tillage process in Chengdu Plain - Lei Du; Xizhou Zhang; Zicheng Zheng; Tingxuan Li; Yongdong Wang; Huagang Huang; Haiying Yu; Daihua Ye; Tao Liu (Journal of Soils and Sediments, 2020)

Characteristics of methane emissions in the Living Water Garden in Chengdu City from 2012 to 2017 - Ru Xue; Xiaoling Liu; Xiaoying Fu; Hongbing Luo; Ke Zhang; Bruce C. Anderson; Mei Li; Bo Huang; Lijuan Yu; Xiaoting Li; Shuzhi Fu; Aiping Pu; et al. (Environmental Science and Pollution Research, 2020)

Algicidal properties of fermentation products from Bacillus cereus strain JZBC1 dissolving dominant dinoflagellate species Scrippsiella trochoidea, Prorocentrum micans, and Peridinium umbonatum - Xiaojuan Hu; Haochang Su; Yu Xu; Wujie Xu; Shasha Li; Xiaoshuai Huang; Yucheng Cao; Guoliang Wen (Biologia, 2020)

Isopimarane-type diterpenoids from Croton laevigatus - Man-Yu Li; Zheng-Zhi Han; Li-Fang Liu; Xiao-Zhen Wu; Wen-Jun Huang; Kai Wang; Fan Yang; Cheng-Shan Yuan (Natural Product Research, 2020)

Identification of a genomic region controlling thermotolerance at flowering in maize using a combination of whole genomic re-sequencing and bulked segregant analysis - Wei Zeng; Jian Shi; Chunhong Qiu; Yunhe Wang; Shamsur Rehman; Shuaishuai Yu; Shijie Huang; Chen He; Wanyi Wang; Hongyi Chen; Chen Chen; Chuanhong Wang; et al. (Theoretical and Applied Genetics, 2020)

Evaluating the effect of plain afforestation project and future spatial suitability in Beijing - Tengyun Hu; Xuecao Li; Peng Gong; Wencheng Yu; Xiaochun Huang (Science China Earth Sciences, 2020)

Genetic diversity comparisons of wild populations of Nelumbo nucifera (Nelumbonaceae) in Russia and China using microsatellite markers - Zhi-Zhong Li; Md. Rabiul Islam; Shi-Xu Huang; Dan Yang; Yeshitila Mekbib; Popova Svetlana; Hong-Bing Sun; Jin-Ming Chen; Xing-Yu Yang (Plant Systematics and Evolution, 2020)

MicroRNA-203a regulates pancreatic β cell proliferation and apoptosis by targeting IRS2 - Xianlan Duan; Lian Zhao; Wancun Jin; Qinxin Xiao; Yani Peng; Gan Huang; Xia Li; Sonia DaSilva-Arnold; Haibo Yu; Zhiguang Zhou (Molecular Biology Reports, 2020)

Sulfur isotope and trace element compositions of pyrite determined by NanoSIMS and LA-ICP-MS: new constraints on the genesis of the Shuiyindong Carlin-like gold deposit in SW China - Jin-xiang Li; Rui-zhong Hu; Cheng-hai Zhao; Jing-jing Zhu; Yong Huang; Wei Gao; Jin-wei Li; Yu-zhou Zhuo (Mineralium Deposita, 2020)

A stacked sparse auto-encoder and back propagation network model for sensory event detection via a flexible ECoG - Oluwagbenga Paul Idowu; Jianping Huang; Yang Zhao; Oluwarotimi William Samuel; Mei Yu; Peng Fang; Guanglin Li (Cognitive Neurodynamics, 2020)

Associations of egg consumption with incident cardiovascular disease and all-cause mortality - Xue Xia; Fangchao Liu; Xueli Yang; Jianxin Li; Jichun Chen; Xiaoqing Liu; Jie Cao; Chong Shen; Ling Yu; Yingxin Zhao; Xianping Wu; Liancheng Zhao; et al. (Science China Life Sciences, 2020)

Molecular diversity of the microbial community in coloured snow from the Fildes Peninsula (King George Island, Maritime Antarctica) - Wei Luo; Haitao Ding; Huirong Li; Zhongqiang Ji; Kaiyao Huang; Wenyu Zhao; Yong Yu; Yinxin Zeng (Polar Biology, 2020)

The abscisic acid receptor gene VvPYL4 positively regulates grapevine resistance to Plasmopara viticola - Li Liu; Chang-Yuan Liu; Hui Wang; Shu-Yi Yu; Tian-Shu Guan; Yu-Fei Huang; Rui-Chun Li (Plant Cell, Tissue and Organ Culture (PCTOC), 2020)

Correction to: Long non-coding RNA H19 promotes osteogenic differentiation of renal interstitial fibroblasts through Wnt-β-catenin pathway - Zewu Zhu; Yu Cui; Fang Huang; Huimin Zeng; Weiping Xia; Feng Zeng; Cheng He; Jinbo Chen; Zhiyong Chen; Hequn Chen; Yang Li (Molecular and Cellular Biochemistry, 2020)

Genome-wide analysis of long noncoding RNA profiles in Vero cells infected with porcine epidemic diarrhea virus - Linyang Yu; Jianguo Dong; Yanling Liu; Leyi Zhang; Pengshuai Liang; Lei Wang; Li Huang; Zheng Xu; Changxu Song (Archives of Virology, 2020)

Identification and genome characterization of a novel picornavirus from ducks in China - Yufeng Li; Kaicheng Wang; Kexiang Yu; Feng Hu; Xue Tian; Bing Huang; Hualei Liu; Jiaqiang Wu; Minxun Song (Archives of Virology, 2020)

A Review of Co3O4-based Catalysts for Formaldehyde Oxidation at Low Temperature: Effect Parameters and Reaction Mechanism - Rong Li; Yu Huang; Dandan Zhu; Wingkei Ho; Shuncheng Lee; Junji Cao (Aerosol Science and Engineering, 2020)

A fundamental theorem for eco-environmental surface modelling and its applications - Tianxiang Yue; Na Zhao; Yu Liu; Yifu Wang; Bin Zhang; Zhengping Du; Zemeng Fan; Wenjiao Shi; Chuanfa Chen; Mingwei Zhao; Dunjiang Song; Shihai Wang; et al. (Science China Earth Sciences, 2020)

Ablation of olfactory bulb glutamatergic neurons induces depressive-like behaviors and sleep disturbances in mice - Mao-Yun Yuan; Ze-Ka Chen; Jian Ni; Tian-Xiao Wang; Shi-Yu Jiang; Hui Dong; Wei-Min Qu; Zhi-Li Huang; Rui-Xi Li (Psychopharmacology, 2020)

Candidate resistance genes selection and transcriptome analysis for the early responses to Plasmopara viticola infection in grape cultivars - Li Liu; Bo Zhang; Hui Wang; Shu Yi Yu; Tian Shu Guan; Yu Fei Huang; Chang Yuan Liu (Journal of Plant Pathology, 2020)

Synergistic effects of pazopanib and hyperthermia against uterine leiomyosarcoma growth mediated by downregulation of histone acetyltransferase 1 - Chiao-Yun Lin; Angel Chao; Ren-Chin Wu; Li-Yu Lee; Shir-Hwa Ueng; Chia-Lung Tsai; Yun-Shien Lee; Meng-Ting Peng; Lan-Yan Yang; Huei-Jean Huang; Hsin-Shih Wang; Chyong-Huey Lai (Journal of Molecular Medicine, 2020)

Telephone Follow-up Design and Practice for Advanced Cancer Pain Patients - Benyan Zou; Xuling Li; Xuxia Huang; Dandan Xiong; Yu Liu (Journal of Cancer Education, 2020)

Water environment in the Tibetan Plateau: heavy metal distribution analysis of surface sediments in the Yarlung Tsangpo River Basin - Zheng Li; Jiaju Liu; Hulin Chen; Qingqing Li; Can Yu; Xiang Huang; Huaicheng Guo (Environmental Geochemistry and Health, 2020)

Taxonomy and Phylogeny of a New Marine Planktonic Ciliate, Strombidium pseudorapulum sp. n. (Protozoa, Ciliophora, Oligotrichia) - Fenfen Li; Yaoyao Huang; Ying Yu; Weiwei Liu; Xiaofeng Lin (Journal of Ocean University of China, 2020)

Examining Health of Wetlands with Multiple Ecosystem Services as Targets in China’s Coastal Regions - Yangming Zhou; Yuehan Dou; Xiubo Yu; Li Zhang; Chong Huang; Yuyu Wang; Xiaowei Li; He Li; Yifei Jia; Martha Bakker; Gerrit Jan Carsjens; Yan Zhou; et al. (Chinese Geographical Science, 2020)

Acanthophoraine A, a new pyrrolidine alkaloid from the red alga Acanthophora spicifera - Jia-Li Lin; Yong-Qian Liang; Xiao-Jian Liao; Jian-Ting Yang; Dai-Chun Li; Yu-Ling Huang; Zhi-Hui Jiang; Shi-Hai Xu; Bing-Xin Zhao (Natural Product Research, 2020)

Antimony-oxidizing bacteria alleviate Sb stress in Arabidopsis by attenuating Sb toxicity and reducing Sb uptake - Tianyuan Gu; Huang Yu; Fang Li; Weimin Zeng; Xueling Wu; Li Shen; Runlan Yu; Yuandong Liu; Jiaokun Li (Plant and Soil, 2020)

Astrocytic GABAB Receptors in Mouse Hippocampus Control Responses to Behavioral Challenges through Astrocytic BDNF - Ji-Hong Liu; Ze-Lin Li; Yi-Si Liu; Huai-De Chu; Neng-Yuan Hu; Ding-Yu Wu; Lang Huang; Shu-Ji Li; Xiao-Wen Li; Jian-Ming Yang; Tian-Ming Gao (Neuroscience Bulletin, 2020)

Long non-coding RNA H19 promotes osteogenic differentiation of renal interstitial fibroblasts through Wnt-β-catenin pathway - Zewu Zhu; Yu Cui; Fang Huang; Huimin Zeng; Weiping Xia; Feng Zeng; Cheng He; Jinbo Chen; Zhiyong Chen; Hequn Chen; Yang Li (Molecular and Cellular Biochemistry, 2020)

Targeting Inflammation, PHA-767491 Shows a Broad Spectrum in Protein Aggregation Diseases - Yu-Han Chung; Chia-Wei Lin; Hsin-Yu Huang; Shu-Ling Chen; Hei-Jen Huang; Ying-Chieh Sun; Guan-Chiun Lee; Guey-Jen Lee-Chen; Ya-Ching Chang; Hsiu Mei Hsieh-Li (Journal of Molecular Neuroscience, 2020)

Hepatitis B virus X protein promotes liver cell pyroptosis under oxidative stress through NLRP3 inflammasome activation - Wen-hui Xie; Jian Ding; Xiao-xia Xie; Xiao-huang Yang; Xiao-Fan Wu; Zhi-xin Chen; Qi-lan Guo; Wen-yu Gao; Xiao-zhong Wang; Dan Li (Inflammation Research, 2020)
Objective Hepatitis B virus X protein (HBx) is a pivotal factor for HBV-induced hepatitis. Herein, we sought to investigate HBx-mediated NLR pyrin domain containing 3 (NLRP3) inflammasome activation and pyroptosis under oxidative stress. Methods The effect of HBx on the NLRP3 inflammasome was analyzed by enzyme-linked immunosorbent assays, quantitative reverse transcription-polymerase chain reaction, western blotting, and immunofluorescence in hepatic HL7702 cells. Pyroptosis was evaluated by western blotting, lactate dehydrogenase release, propidium iodide staining, and transmission electron microscopy. NLRP3 expression in the inflammasome from liver tissues was assessed by immunohistochemistry. Results In hydrogen peroxide (H 2 O 2 )-stimulated HL7702 cells, HBx triggered the release of pro-inflammatory mediators apoptosis-associated speck-like protein containing a CARD (ASC), interleukin (IL)-1β, IL-18, and high-mobility group box 1 (HMGB1); activated NLRP3; and initiated pro-inflammatory cell death (pyroptosis). HBx localized to the mitochondria, where it induced mitochondrial damage and production of mitochondrial reactive oxygen species (mitoROS). Treatment of HL7702 cells with a mitoROS scavenger attenuated HBx-induced NLRP3 activation and pyroptosis. Expression levels of NLRP3, ASC, and IL-1β in liver tissues from patients were positively correlated with HBV DNA concentration. Conclusions The NLRP3 inflammasome was activated by elevated mitoROS levels and mediated HBx-induced liver inflammation and hepatocellular pyroptosis under H 2 O 2 -stress conditions.

Green chemistry: efficient acetalization of aldehydes with alcohols using the acid red 52 photocatalyst - Linyu Yu; Chuyuan Lin; Chunshu Liao; Xianghua Zeng; Xiuwen Chen; Zhongzhi Zhu; Yubing Huang; Yibiao Li; Lu Chen (Environmental Chemistry Letters, 2020)

Phytochemical constituents of the pericarps of Illicium difengpi and their anti-inflammatory activity - De-Sheng Ning; Yu-Xia Fu; Li-Yan Peng; Hui Tang; Lian-Chun Li; Xing-De Wu; Yu-Song Huang; Zheng-Hong Pan (Natural Product Research, 2020)

Adsorption Mechanisms and Electrochemical Properties of Methyl Blue onto Magnetic NixMgyZn(1-x-y)Fe2O4 Nanoparticles Fabricated Via the Ethanol-Assisted Combustion Process - Lulu Yu; You Li; Shuai Pan; Wei Huang; Ruijiang Liu (Water, Air, & Soil Pollution, 2020)

Development of a specific AFLP-based SCAR marker for Chinese Race 34MKG of Puccinia graminis f. sp. tritici - Si Chen; Xue Yang; Wen-gong Huang; Yan Liu; Ying Yu; Guang-wen Wu; Shu-quan Zhang; Tian-ya Li; Yuan-yin Cao (Molecular Biology Reports, 2020)

Causes and Changes of Drought in China: Research Progress and Prospects - Qiang Zhang; Yubi Yao; Yaohui Li; Jianping Huang; Zhuguo Ma; Zhilan Wang; Suping Wang; Ying Wang; Yu Zhang (Journal of Meteorological Research, 2020)

Epidemiology and HBGA-susceptibility investigation of a G9P[8] rotavirus outbreak in a school in Lechang, China - Lun-Ai Guo; Meng Zhang; Yu-zhen Hou; Haitao Hu; Ling Fang; Ming Tan; Qiong Huang; Hui Li; Li-Mei Sun; Xi Jiang; Wen-Fang Tan; Shixing Tang; et al. (Archives of Virology, 2020)

Combined effect of polymorphisms of MTHFR and MTR and arsenic methylation capacity on developmental delay in preschool children in Taiwan - Yu-Mei Hsueh; Ying-Chin Lin; Chi-Jung Chung; Ya-Li Huang; Ru-Lan Hsieh; Pai-Tsang Huang; Mei-Yi Wu; Horng-Sheng Shiue; Ssu-Ning Chien; Chih-Ying Lee; Ming-I. Lin; Shu-Chi Mu; et al. (Archives of Toxicology, 2020)

Predicting postmortem interval based on microbial community sequences and machine learning algorithms - Ruina Liu; Yuexi Gu; Mingwang Shen; Huan Li; Kai Zhang; Qi Wang; Xin Wei; Haohui Zhang; Di Wu; Kai Yu; Wumin Cai; Gongji Wang; et al. (Environmental Microbiology, 2020)
Summary Microbes play an essential role in the decomposition process but were poorly understood in their succession and behaviour. Previous researches have shown that microbes show predictable behaviour that starts at death and changes during the decomposition process. Research of such behaviour enhances the understanding of decomposition and benefits estimating the postmortem interval (PMI) in forensic investigations, which is critical but faces multiple challenges. In this study, we combined microbial community characterization, microbiome sequencing from different organs (i.e. brain, heart and cecum) and machine learning algorithms [random forest (RF), support vector machine (SVM) and artificial neural network (ANN)] to investigate microbial succession pattern during corpse decomposition and estimate PMI in a mouse corpse system. Microbial communities exhibited significant differences between the death point and advanced decay stages. Enterococcus faecalis , Anaerosalibacter bizertensis , Lactobacillus reuteri , and so forth were identified as the most informative species in the decomposition process. Furthermore, the ANN model combined with the postmortem microbial data set from the cecum, which was the best combination among all candidates, yielded a mean absolute error of 1.5 ± 0.8 h within 24‐h decomposition and 14.5 ± 4.4 h within 15‐day decomposition. This integrated model can serve as a reliable and accurate technology in PMI estimation.

Detection of serum IgM and IgG for COVID-19 diagnosis - Ling Zhong; Junlan Chuan; Bo Gong; Ping Shuai; Yu Zhou; Yi Zhang; Zhilin Jiang; Dingding Zhang; Xiaoqi Liu; Shi Ma; Yi Huang; He Lin; et al. (Science China Life Sciences, 2020)

NK cell reconstitution following unmanipulated HLA-mismatched/haploidentical transplantation compared with matched sibling transplantation - Li-Juan Hu; Xun-Hong Cao; Xing-Xing Yu; Xue-Fei Liu; Xiao-Su Zhao; Ying-Jun Chang; Xiao-Hui Zhang; Lan-Ping Xu; Yu Wang; Kai-Yan Liu; Xiao-Jun Huang; Xiang-Yu Zhao (Science China Life Sciences, 2020)

First report of powdery mildew on Bidens pilosa var. radiata and Passiflora edulis f. flavicarpa caused by Golovinomyces circumfusus in Taiwan - Tsung-Chun Lin; Yu-Lun Dai; Cing-Siang You; Jenn-Wen Huang; Chih-Li Wang (Journal of Plant Pathology, 2020)

Low-temperature laminar flow ward for the treatment of multidrug resistance Acinetobacter baumannii pneumonia - Zhitao Gong; Jin Li; Hongliang Luo; Daqiang Zhan; Xuanhui Liu; Chuang Gao; Jinhao Huang; Yu Qian; Yiming Song; Wei Quan; Shuo An; Ye Tian; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2020)

Fractionation and chemical structure of dissolved organic matter in the rhizosphere associated with cadmium accumulation in tobacco lines (Nicotiana tabacum L.) - Ming Zhao; Tingxuan Li; Haiying Yu; Xizhou Zhang; Zicheng Zheng; Yongdong Wang; Tao Liu; Dharmendra K. Gupta; Huagang Huang (Environmental Science and Pollution Research, 2020)

SP94 Peptide-Functionalized PEG-PLGA Nanoparticle Loading with Cryptotanshinone for Targeting Therapy of Hepatocellular Carcinoma - Xiaoling Nie; Yuan Liu; Ming Li; Xuesong Yu; Wanwen Yuan; Sixi Huang; Di Ren; Ying Wang; Yan Wang (AAPS PharmSciTech, 2020)

Antiviral activity of Illicium verum Hook. f. extracts against grouper iridovirus infection - Mingzhu Liu; Qing Yu; Hehe Xiao; Yi Yi; Hao Cheng; Dedi Fazriansyah Putra; Yaming Huang; Qin Zhang; Pengfei Li (Journal of Fish Diseases, 2020)
Grouper iridovirus causes high mortality rates in cultured groupers, and effective treatment for grouper iridovirus infection is urgently required. Illicium verum Hook. f. is a well‐known medicinal plant with a variety of biological activities. The aim of this study was to analyse the use of I. verum extracts to treat grouper iridovirus infection. The safe working concentration of each I. verum extract was identified both in vitro and in vivo as follows: I. verum aqueous extract (IVAE) ≤ 500 μg/ml; I. verum ethanol extract (IVEE) ≤ 250 μg/ml; shikimic acid (SKA) ≤ 250 μg/ml; trans‐anethole (TAT) ≤ 800 μg/ml; 3,4‐dihydroxybenzoic acid (DDBA) ≤ 400 μg/ml; and quercetin (QCE) ≤ 50 μg/ml. The inhibitory activity of each I. verum extract against grouper iridovirus infection was analysed using aptamer (Q2)‐based fluorescent molecular probe (Q2‐AFMP) and RT‐qPCR. All of the I. verum extracts displayed dose‐dependent antiviral activities against grouper iridovirus. Based on the achieved per cent inhibition, IVAE, IVEE, DDBA and QCE were associated with the greatest antiviral activity (all > 90%). Together, our results indicate that I. verum extracts have effective antiviral properties, making it an excellent potential source material for the development of effective treatment for grouper iridovirus infection.

What causes variable response in tree growth to climate change at a single site? A case study of Picea crassifolia at the upper treeline, Qilian Mountains, China - Yongxiang Zhang; Michael N. Evans; Li Yu; Lei Huang; Yanfang Wang (Trees, 2020)

Vortioxetine administration attenuates cognitive and synaptic deficits in 5×FAD mice - Li-Xin Jiang; Geng-Di Huang; Feng Su; Huali Wang; Chen Zhang; Xin Yu (Psychopharmacology, 2020)

Thioredoxin-Interacting Protein (TXNIP) Regulates Parkin/PINK1-mediated Mitophagy in Dopaminergic Neurons Under High-glucose Conditions: Implications for Molecular Links Between Parkinson’s Disease and Diabetes - Cun-Jin Su; Zhu Shen; Ru-Xiao Cui; Ya Huang; De-Lai Xu; Feng-Lun Zhao; Jie Pan; Ai-Ming Shi; Tong Liu; Yun-Li Yu (Neuroscience Bulletin, 2020)

A new DRP-4DVar-based coupled data assimilation system for decadal predictions using a fast online localization technique - Yujun He; Bin Wang; Wenyu Huang; Shiming Xu; Yong Wang; Li Liu; Lijuan Li; Juanjuan Liu; Yongqiang Yu; Yanluan Lin; Xiaomeng Huang; Yiran Peng (Climate Dynamics, 2020)

Deformation behaviors of dip slopes considering the scale effect and their geological properties - Wen-Chao Huang; Kun-Che Li; Jheng-Yu Hsieh; Meng-Chia Weng; Wen-Yi Hung (Bulletin of Engineering Geology and the Environment, 2020)

Increased interregional functional connectivity of anterior insula is associated with improved smoking cessation outcome - Chao Wang; Zhujing Shen; Peiyu Huang; Wei Qian; Cheng Zhou; Kaicheng Li; Qingze Zeng; Xiao Luo; Quanquan Gu; Hualiang Yu; Yihong Yang; Minming Zhang (Brain Imaging and Behavior, 2020)

Interannual Variability and Scenarios Projection of Sea Ice in Bohai Sea Part I: Variation Characteristics and Interannual Hindcast - Yan Jiao; Fei Huang; Qingrong Liu; Ge Li; Yaru Li; Qingxi Yu; Yiding Zhao (Journal of Ocean University of China, 2020)

Separation and preparation of N-glycans based on ammonia-catalyzed release method - Meifang Yang; Ming Wei; Chengjian Wang; Yu Lu; Wanjun Jin; Xi Gao; Cheng Li; Langhong Wang; Linjuan Huang; Zhongfu Wang (Glycoconjugate Journal, 2020)

Short communication: recovery of Vibrio vulnificus from head ulceration in seahorse (Hippocampus kuda) - Fangyan Jiang; Ning Yang; Hai Huang; Huimin Feng; Yu Li; Bingbing Han (Aquaculture International, 2020)

Poly(L-Glutamic Acid)-Based Brush Copolymers: Fabrication, Self-assembly, and Evaluation as Efficient Nanocarriers for Cationic Protein Drug Delivery - Xin Li; Chao Lu; Wenquan Xia; Guilan Quan; Ying Huang; Xuequn Bai; Feiyuan Yu; Qian Xu; Wanbing Qin; Daojun Liu; Xin Pan (AAPS PharmSciTech, 2020)

Bioaugmentation-assisted phytoremediation of manganese and cadmium co-contaminated soil by Polygonaceae plants (Polygonum hydropiper L. and Polygonum lapathifolium L.) and Enterobacter sp. FM-1 - Yi Li; Jiamin Lin; Yuanyuan Huang; Yawei Yao; Xueru Wang; Chengzhao Liu; Ying Liang; Kehui Liu; Fangming Yu (Plant and Soil, 2020)

Chloroplast genome of an extremely endangered conifer Thuja sutchuenensis Franch.: gene organization, comparative and phylogenetic analysis - Tao Yu; Bing-Hong Huang; Yuyang Zhang; Pei-Chun Liao; Jun-Qing Li (Physiology and Molecular Biology of Plants, 2020)

Stochastic assessment of slope failure run-out triggered by earthquake ground motion - Yu Huang; Geye Li; Min Xiong (Natural Hazards, 2020)

AGONOTES: A Robot Annotator for Argonaute Proteins - Lixu Jiang; Min Yu; Yuwei Zhou; Zhongjie Tang; Ning Li; Juanjuan Kang; Bifang He; Jian Huang (Interdisciplinary Sciences: Computational Life Sciences, 2020)