Correlations between Dual-Pathway White Matter Alterations and Language Impairment in Patients with Aphasia: A Systematic Review and Meta-analysis - Jie Zhang; Shuchang Zhong; Liang Zhou; Yamei Yu; Xufei Tan; Min Wu; Peng Sun; Wei Zhang; Juebao Li; Ruidong Cheng; Yanfei Wu; Yanmei Yu; et al. (Neuropsychology Review, 2021)

Enhanced degradation of reactive brilliant red X-3B by photocatalysis integrated with micro-electrolysis - Gong Cheng; Yibo Zhang; Lei Sun; Jing Wan; Zhang Li; Chenyuan Dang; Jie Fu (Environmental Science and Pollution Research, 2021)

Use of housefly (Musca domestica L.) larvae to bioconversion food waste for animal nutrition and organic fertilizer - Zhang Cheng; Lin Yu; Hahan Li; Xiaoxun Xu; Zhanbiao Yang (Environmental Science and Pollution Research, 2021)

Particulate matter pollution and emergency room visits for respiratory diseases in a valley Basin city of Northwest China - Bowen Cheng; Yuxia Ma; Hang Wang; Jiahui Shen; Yifan Zhang; Lingyun Guo; Yongtao Guo; Mingji Li (Environmental Geochemistry and Health, 2021)

Acute associations between air pollution on premature rupture of membranes in Hefei, China - Chao Zhang; Sha Li; Gan-lan Guo; Jing-wen Hao; Peng Cheng; Li-lin Xiong; Shu-ting Chen; Ji-yu Cao; Yu-wen Guo; Jia-hu Hao (Environmental Geochemistry and Health, 2021)

Human Methylmercury Exposure and Potential Impacts in Central Tibet: Food and Traditional Tibetan Medicine - Menghan Cheng; Maodian Liu; Dou Li; Qing Luo; Zhihao Zhang; Liuliang Yuan; Chenghao Yu; Han Xie; Huiming Lin; Qianru Zhang; De Ji; Xuejun Wang (Bulletin of Environmental Contamination and Toxicology, 2021)

Identification of a 193 bp promoter region of TaNRX1-D gene from common wheat that contributes to osmotic or ABA stress inducibility in transgenic Arabidopsis - Jie Cheng; Fan Wei; Mingfei Zhang; Nan Li; Tianqi Song; Yong Wang; Dongsheng Chen; Jishan Xiang; Xiaoke Zhang (Genes & Genomics, 2021)

Novel Dicistroviruses in an Unexpected Wide Range of Invertebrates - Ruo-Lin Cheng; Xiao-Feng Li; Chuan-Xi Zhang (Food and Environmental Virology, 2021)

3D Step-by-step inversion strategy for audio magnetotellurics data based on unstructured mesh - San Cheng; Zhi-Yong Zhang; Feng Zhou; Man Li; Hui Chen; Fu-Sheng Shi; Lin-Pin Huang; Yong Li (Applied Geophysics, 2021)

Modulation of the 5-HT 3 A receptor current by desacylbaldrinal - Li-Xia Wang; Hu-Lan Chen; Hong-Ling Yan; Fei Tang; Hai Zhang; Hong-Xiang Li; Qiang Ye; Cheng Peng; Yu-Zhu Tan (Natural Product Research, 2021)

Proteomics provides individualized options of precision medicine for patients with gastric cancer - Wenwen Huang; Dongdong Zhan; Yazhuo Li; Nairen Zheng; Xin Wei; Bin Bai; Kecheng Zhang; Mingwei Liu; Xuefei Zhao; Xiaotian Ni; Xia Xia; Jinwen Shi; et al. (Science China Life Sciences, 2021)

Identification and function analysis of fasciclin-like arabinogalactan protein family genes in pear (Pyrus bretschneideri) - Xiaoqiang Li; Mengyu Cheng; Chao Tang; Xiaoxuan Zhu; Kaijie Qi; Shaoling Zhang; Juyou Wu; Peng Wang (Plant Systematics and Evolution, 2021)

The Water-Soluble Pool in Biochar Dominates Maize Plant Growth Promotion Under Biochar Amendment - Cheng Liu; Baobao Sun; Xuhui Zhang; Xiaoyu Liu; Marios Drosos; Lianqing Li; Genxing Pan (Journal of Plant Growth Regulation, 2021)

Physical Model Tests on the Effect of Anchoring on the Splitting Failure of Deep Large-Scale Underground Rock Cavern - Guangyuan Yu; Qiangyong Zhang; Fan Li; Lei Cheng; Xin Guo (Geotechnical and Geological Engineering, 2021)

Estimation of the SARS-CoV-2 transmission probability in confined traffic space and evaluation of the mitigation strategies - Linlin Chen; Guangze Ban; Enshen Long; Gretchen Kalonji; Zhu Cheng; Li Zhang; Shurui Guo (Environmental Science and Pollution Research, 2021)

Removal of N,N-dimethylformamide by dielectric barrier discharge plasma combine with manganese activated carbon - Wenjiao Sang; Longjie Mei; Cheng Zhan; Qian Zhang; Xi Jin; Shaohui Zhang; Shiyang Zhang; Cuihua Li; Min Li (Environmental Science and Pollution Research, 2021)

Long-term impact of ambient air pollution on preterm birth in Xuzhou, China: a time series study - Sha Li; Lei Peng; Xiaochang Wu; Geng Xu; Peng Cheng; Jingwen Hao; Zhaohui Huang; Meng Xu; Shuting Chen; Chao Zhang; Jiahu Hao (Environmental Science and Pollution Research, 2021)

Maternal exposure to sulfur dioxide and the risk of oral clefts in Liaoning Province, China: a population-based case-control study - Fang-Hua Liu; Ze Xing; Ting-Ting Gong; Jia-Yu Zhang; Yan-Hong Huang; Jing Li; Shu Liu; Yan-Ling Chen; Li-Li Li; Cheng-Zhi Jiang; Zong-Jiao Chen; Yu-Hong Zhao; et al. (Environmental Science and Pollution Research, 2021)

The correlation of altitude with gingival status among adolescents in western China: a cross-sectional study - Zhiwu Wu; Rui Zhang; Li Cheng; Ruilie Cai; Hong Chen; Ran Cheng; Tao Hu (Environmental Geochemistry and Health, 2021)

Impact of the April–May SAM on Central Pacific Ocean sea temperature over the following three seasons - Ting Liu; Jianping Li; Cheng Sun; Tao Lian; Yazhou Zhang (Climate Dynamics, 2021)
Although the impact of the extratropical Pacific signal on the El Niño–Southern Oscillation has attracted increasing concern, the impact of Southern Hemisphere Annular Mode (SAM)-related signals from outside the southern Pacific Basin on the equatorial sea temperature has received less attention. This study explores the lead correlation between the April–May (AM) SAM and central tropical Pacific sea temperature variability over the following three seasons. For the positive AM SAM case, the related simultaneous warm SST anomalies in the southeastern Indian Ocean favor significant regulation of vertical circulation in the Indian Ocean with anomalous ascending motion in the tropics. This can further enhance convection over the Marine Continent, which induces a significant horizontal Kelvin response and regulates the vertical Walker circulation. These two processes both result in the anomalous easterlies east of 130° E in the equatorial Pacific during AM. These easterly anomalies favor oceanic upwelling and eastward propagation of the cold water into the central Pacific. The cold water in turn amplifies the development of the easterly wind and further maintains the cold water into the boreal winter. The results presented here not only provide a possible link between extratropical climate variability in the Indian Ocean and climate variation in the equatorial Pacific, but also shed new light on the short-term prediction of tropical central Pacific sea temperature.

Sum of High-Risk Gene Mutation (SHGM): A Novel Attempt to Assist Differential Diagnosis for Adrenocortical Carcinoma with Benign Adenoma, Based on Detection of Mutations of Nine Target Genes - Guo-Yang Zheng; Xue-Bin Zhang; Han-Zhong Li; Yu-Shi Zhang; Jian-Hua Deng; Xing-Cheng Wu (Biochemical Genetics, 2021)
There has been no research on applying gene detection to differential diagnosis of adrenocortical carcinoma (ACC). We attempted to explore a novel auxiliary method for differential diagnosis between ACC with benign adrenocortical adenoma (ACA), based on mutations of target genes in tissues. Nine genes were chosen as target genes, including TP53, CTNNB1, ARMC5, PRKAR1A, ZNRF3, RB1, APC, MEN1, and RPL22 . Exons sequencing of target genes were performed in 98 cases of tissue samples by FastTarget technology, including 41 ACC tissues, 32 ACA tissues, and 25 normal adrenal gland tissues. Significant mutations were detected and identified, and the clinical information was collected, for further comparative analysis and application to assist differential diagnosis of ACC. We identified 132 significant gene mutations and 227 significant mutation sites in 37 ACC tissues, much more than ACA and normal adrenal gland tissues. Mutation rates of 6 genes in ACC tissues were obviously higher than ACA tissues, including ZNRF3, ARMC5, TP53, APC, RB1, and PRKAR1A , regarded as high-risk genes. The sum of mutated high-risk genes detected in each sample was denominated sum of high-risk gene mutation (SHGM), and the rates of SHGM > 0 and SHGM > 1 in ACC tissues were 73.0% and 62.2%, respectively, both obviously higher than those in ACA tissues, with significant statistic differences. Especially for 8 cases of ACC with diameter 0 and SHGM > 1 were found in 6 samples (75%) and 4 samples (50%), respectively. However, no relevance was found between SHGM and clinical characteristics of ACC. We identified 6 high-risk genes in ACC tissues, with significantly higher mutation rates than ACA or normal adrenal gland tissues. The sum of mutated high-risk genes detected in ACC tissues was denominated SHGM, which was potential to assist the differential diagnosis of ACC with ACA, especially for the small-size ACC.

RETRACTED ARTICLE: Simulation of plain rainfall runoff and monitoring of basketball players’ sports fatigue based on heterogeneous computing - Li Fenglei; Zhang Shengnian; Cheng Wanxiang (Arabian Journal of Geosciences, 2021)

The developmental regulator PatD modulates assembly of the cell‐division protein FtsZ in the cyanobacterium Anabaena sp. PCC 7120 - Li Wang; Tian‐Cai Niu; Ana Valladares; Gui‐Ming Lin; Ju‐Yuan Zhang; Antonia Herrero; Wen‐Li Chen; Cheng‐Cai Zhang (Environmental Microbiology, 2021)
Summary FtsZ is a tubulin‐like GTPase that polymerizes to initiate the process of cell division in bacteria. Heterocysts are terminally differentiated cells of filamentous cyanobacteria that have lost the capacity for cell division and in which the ftsZ gene is downregulated. However, mechanisms of FtsZ regulation during heterocyst differentiation have been scarcely investigated. The patD gene is NtcA dependent and involved in the optimization of heterocyst frequency in Anabaena sp. PCC 7120. Here, we report that the inactivation of patD caused the formation of multiple FtsZ‐rings in vegetative cells, cell enlargement, and the retention of peptidoglycan synthesis activity in heterocysts, whereas its ectopic expression resulted in aberrant FtsZ polymerization and cell division. PatD interacted with FtsZ, increased FtsZ precipitation in sedimentation assays, and promoted the formation of thick straight FtsZ bundles that differ from the toroidal aggregates formed by FtsZ alone. These results suggest that in the differentiating heterocysts, PatD interferes with the assembly of FtsZ. We propose that in Anabaena FtsZ is a bifunctional protein involved in both vegetative cell division and regulation of heterocyst differentiation. In the differentiating cells PatD‐FtsZ interactions appear to set an FtsZ activity that is insufficient for cell division but optimal to foster differentiation.

Natural constituents from food sources as therapeutic agents for obesity and metabolic diseases targeting adipose tissue inflammation - Dan Li; Tian Zhang; Jinjian Lu; Cheng Peng; Ligen Lin (Critical Reviews in Food Science and Nutrition, 2021)

Quantifying nitrate pollution sources of the drinking water source area using a Bayesian isotope mixing model in the northeastern suburbs of Beijing, China - Liangsuo Ren; Lirong Cheng; Shurong Zhang; Aizhong Ding; Yi Zhu; Chunlei Lu; Yu Li; Qing Yang; Jie Li (Isotopes in Environmental and Health Studies, 2021)

Citrus NIP5;1 aquaporin regulates cell membrane water permeability and alters PIPs plasma membrane localization - Mingfei Zhang; Ruilian Liu; Hai Liu; Hongbin Yang; Xin Li; Ping Wang; Feng Zhu; Rangwei Xu; Shaowu Xue; Yunjiang Cheng (Plant Molecular Biology, 2021)

Restricted Feeding Resets Endogenous Circadian Rhythm in Female Mice Under Constant Darkness - Yue Mei; Huajing Teng; Zhigang Li; Cheng Zeng; Yuanyuan Li; Wei Song; Kaifan Zhang; Zhong Sheng Sun; Yan Wang (Neuroscience Bulletin, 2021)

Genetic Analysis of ZNF Protein Family Members for Early-Onset Parkinson’s Disease in Chinese Population - Chun Yu Li; Ru Wei Ou; Yong Ping Chen; Xiao Jing Gu; Qian Qian Wei; Bei Cao; Ling Yu Zhang; Yan Bing Hou; Kun Cheng Liu; Xue Ping Chen; Wei Song; Bi Zhao; et al. (Molecular Neurobiology, 2021)

μ-Opioid Receptor–Mediated Enteric Glial Activation Is Involved in Morphine-Induced Constipation - Hui Gao; Yuxin Zhang; Yansong Li; Haiqing Chang; Bo Cheng; Na Li; Wei Yuan; Shuang Li; Qiang Wang (Molecular Neurobiology, 2021)

The influence of VDR polymorphisms on the type 2 diabetes susceptibility in Chinese: an interaction with hypertriglyceridemia - Dongdong Zhang; Cheng Cheng; Yan Wang; Yuan Xue; Yaping Liu; Yiming Liu; Mingming Feng; Ze Xu; Wenjie Li; Xing Li (Molecular Genetics and Genomics, 2021)

Identification of potential sex-related genes in Siniperca chuatsi - Qiaoying Zhu; Chong Han; Cheng Peng; Xingni Zhou; Chongwei Wang; Linqiang Han; Shuisheng Li; Guifeng Li; Haoran Lin; Yong Zhang (Journal of Oceanology and Limnology, 2021)

Could biochar amendment be a tool to improve soil availability and plant uptake of phosphorus? A meta-analysis of published experiments - Fitsum Tesfaye; Xiaoyu Liu; Jufeng Zheng; Kun Cheng; Rongjun Bian; Xuhui Zhang; Lianqing Li; Marios Drosos; Stephen Joseph; Genxing Pan (Environmental Science and Pollution Research, 2021)
As one of the most important nutrients for plant growth, phosphorus was often poorly available in soil. While biochar addition induced improvement of soil structure, nutrient and water retention as well as microbial activity had been well known, and the effect of biochar soil amendment (BSA) on soil phosphorus availability and plant P uptake had been not yet quantitatively assessed. In a review study, data were retrieved from 354 peer-reviewed research articles on soil available P content and P uptake under BSA published by February 2019. Then a database was established of 516 data pairs from 86 studies with and without BSA in agricultural soils. Subsequently, the effect size of biochar application was quantified relative to no application and assessed in terms of biochar conditions, soil conditions, as well as experiment conditions. In grand mean, there was a significant and great effect of BSA on soil available P and plant P uptake by 65% and 55%, respectively. The effects were generally significant under manure biochar, biochar pyrolyzed under 300 °C, soil pH <5 and fine-textured soil, and soils that are very low in available P. Being significantly correlated to soil P availability ( R 2 =0.29), plant P uptake was mostly enhanced with vegetable crops of high biomass yield. Overall, biochar amendment at a dosage up to 10 t ha −1 could be a tool to enhance soil availability and plant uptake of phosphorus, particularly in acid, heavy textured P-poor soils.

Fusarium solani G6, a novel vitexin-producing endophytic fungus: characterization, yield improvement and osteoblastic proliferation activity - Pei-jia Tang; Zhi-hui Zhang; Li-li Niu; Cheng-bo Gu; Wen-yi Zheng; Hai-chao Cui; Xiao-han Yuan (Biotechnology Letters, 2021)

Long-term elevated CO2 and warming enhance microbial necromass carbon accumulation in a paddy soil - Zhiwei Liu; Xiuxia Liu; Xiulan Wu; Rongjun Bian; Xiaoyu Liu; Jufeng Zheng; Xuhui Zhang; Kun Cheng; Lianqing Li; Genxing Pan (Biology and Fertility of Soils, 2021)

Glaciibacter flavus sp. nov., isolated from a lichen sample - De-Feng An; Long-Qian Jiang; Kun Zhang; Gui-Ding Li; Xin-Yu Wang; Ming-Guo Jiang; Lei Lang; Li-Song Wang; Johannes F. Imhoff; Cheng-Lin Jiang; Yi Jiang (Archives of Microbiology, 2021)

Microbulbifer hainanensis sp. nov., a moderately halopilic bacterium isolated from mangrove sediment - Yuping Cheng; Suting Zhu; Chaobo Guo; Feilu Xie; Dawoon Jung; Shengying Li; Weiyan Zhang; Shan He (Antonie van Leeuwenhoek, 2021)

Numerical modeling of the responses of soil temperature and soil moisture to climate change over the Tibetan Plateau, 1961–2010 - Xuewei Fang; Siqiong Luo; Shihua Lyu; Chen Cheng; Zhaoguo Li; Shaobo Zhang (International Journal of Climatology, 2021)
Changes in soil temperature (ST) and soil moisture (SM) are essential for climate change and ecosystem assessments. Previous investigations on the ST and SM on the Tibetan Plateau (TP) are mainly based on the situ observation and the satellite products. In this study, the improved Community Land Model version 4.5 (CLM4.5), with proper parameter optimization and surface datasets update, is used to estimate the response of ST and SM in the TP to climate change in the long‐term time series from 1961 to 2010. After validating the reasonability of the simulated results using the observations, the spatial distribution of changes in ST and SM in annual and seasonal time series since 1960s, 1980s, 1990s, are investigated respectively and the changes of precipitation (Pr) and surface evaporation (Ev) are also analysed to understand the cause of changes objectively. As a whole, the soil was warming and wetting at the maximum value of 0.31°C/decade and 0.77%/decade since the 1960s. However, the warming process in soil mainly occurred in the 1980s while the wetting tendency is detected since the 1990s extensively. Except for the influence of air warming, the enhanced Pr and Ev might also be indispensable factors that caused the intensive wetting process but damped warming process in soil. Summer is the favourable season for the thermal and hydraulic variation since the 1980s. There exists the striking warmer and drier trend in the eastern TP since 1980s while the colder and wetter condition in the western TP since the 1990s. The magnitude of variation in soil is magnified from 1990s under the continuing impact of climate change.

Laboratory shortwave infrared reflectance spectroscopy for estimating grain protein content in rice and wheat - Yan Yan; Xiao Zhang; Dong Li; Hengbiao Zheng; Xia Yao; Yan Zhu; Weixing Cao; Tao Cheng (International Journal of Remote Sensing, 2021)

Comparison of Autogenous Tooth Materials and Other Bone Grafts - Shuxin Zhang; Xuehan Li; Yanxin Qi; Xiaoqian Ma; Shuzhan Qiao; HongXin Cai; Bing Cheng Zhao; Heng Bo Jiang; Eui-Seok Lee (Tissue Engineering and Regenerative Medicine, 2021)

Identification of differentially expressed genes associated with aluminum resistance in the soybean plant - Jing-xuan Wang; Bo Wang; Lu-bin Cui; Hao Xie; Run-zhi Li; Cheng Wang; Zhang-jie Nan; Yu-shu Liu; Jing-yu Ma; Yun-jin Sun; Wei-yu Li (Physiology and Molecular Biology of Plants, 2021)

The Protective Effects of Ropivacaine Against High Glucose-induced Brain Microvascular Endothelial Injury by Reducing MMPs and Alleviating Oxidative Stress - Hu Lv; Qian Cheng; Ying Li; Yue Zhang; Jiawei Chen; Wei Chen (Neurotoxicity Research, 2021)

Using the Metabolome to Understand the Mechanisms Linking Chronic Arsenic Exposure to Microglia Activation, and Learning and Memory Impairment - Rui-Yuan Zhang; Jie-Bai Tu; Rui-Tu Ran; Wen-Xuan Zhang; Qiang Tan; Ping Tang; Tao Kuang; Shu-Qun Cheng; Cheng-Zhi Chen; Xue-Jun Jiang; Chang Chen; Ting-Li Han; et al. (Neurotoxicity Research, 2021)

The Role of lncRNA TUG1 in the Parkinson Disease and Its Effect on Microglial Inflammatory Response - Jiang Cheng; Yangyang Duan; Fengting Zhang; Jin Shi; Hui Li; Feng Wang; Haining Li (NeuroMolecular Medicine, 2021)

Syntheses and anticancer activities of novel glucosylated (−)-epigallocatechin-3-gallate derivatives linked via triazole rings - Bo-Ya Shi; Ze-Hao Wang; Ning Zhang; Yin-Rong Xie; Xiu-Li Sun; Hao-Nan Yang; Yi-Long Wu; Cheng-Ting Zi; Xuan-Jun Wang; Jun Sheng (Medicinal Chemistry Research, 2021)

Response of water quality to land use in hydrologic response unit and riparian buffer along the Dan River, China - Xiaojun Liu; Yi Zhang; Zhanbin Li; Peng Li; Guoce Xu; Yuting Cheng; Tiegang Zhang (Environmental Science and Pollution Research, 2021)

RDF for temporal data management – a survey - Fu Zhang; Zhiyin Li; Dunhong Peng; Jingwei Cheng (Earth Science Informatics, 2021)

Cross-frequency and iso-frequency estimation of functional corticomuscular coupling after stroke - Ping Xie; Xiaohui Pang; Shengcui Cheng; Yuanyuan Zhang; Yinan Yang; Xiaoli Li; Xiaoling Chen (Cognitive Neurodynamics, 2021)

A transcription factor TaTCP20 regulates the expression of Ppd-D1b in common wheat - Fan Wei; Tianqi Song; Jianfei Zhou; Jie Cheng; Ruibo Li; Ming Yu; Yunrui Zhang; Yang Yu; Bo Zhang; Xiaoke Zhang (Plant Biotechnology Reports, 2021)

Geological controls of shale gas accumulation and enrichment mechanism in Lower Cambrian Niutitang Formation of western Hubei, Middle Yangtze, China - Lulu Xu; Saipeng Huang; Zaoxue Liu; Yaru Wen; Xianghui Zhou; Yanlin Zhang; Xiongwei Li; Deng Wang; Fan Luo; Cheng Chen (Frontiers of Earth Science, 2021)

Isolation and characterization of mammalian orthoreovirus type 3 from a fecal sample from a wild boar in Japan - Wenjing Zhang; Michiyo Kataoka; Yen Hai Doan; Toru Oi; Tetsuya Furuya; Mami Oba; Tetsuya Mizutani; Tomoichiro Oka; Tian-Cheng Li; Makoto Nagai (Archives of Virology, 2021)

Design of supercontinuum laser hyperspectral light detection and ranging (LiDAR) (SCLaHS LiDAR) - Guoqing Zhou; Xiang Zhou; Youjian Song; Donghui Xie; Long Wang; Guangjian Yan; Minglie Hu; Bowen Liu; Weidong Shang; Chenghu Gong; Cheng Wang; Huaguo Huang; et al. (International Journal of Remote Sensing, 2021)

Correction to: High‑depth resequencing of 312 accessions reveals the local adaptation of foxtail millet - Congcong Li; Genping Wang; Haiquan Li; Guoliang Wang; Jian Ma; Xin Zhao; Linhe Huo; Liquan Zhang; Yanmiao Jiang; Jiewei Zhang; Guiming Liu; Guoqing Liu; et al. (Theoretical and Applied Genetics, 2021)

High-depth resequencing of 312 accessions reveals the local adaptation of foxtail millet - Congcong Li; Genping Wang; Haiquan Li; Guoliang Wang; Jian Ma; Xin Zhao; Linhe Huo; Liquan Zhang; Yanmiao Jiang; Jiewei Zhang; Guiming Liu; Guoqing Liu; et al. (Theoretical and Applied Genetics, 2021)

Establishment and characterization of 38 novel patient-derived primary cancer cell lines using multi-region sampling revealing intra-tumor heterogeneity of gallbladder carcinoma - Feiling Feng; Qingbao Cheng; Bin Li; Chen Liu; Huizhen Wang; Bin Li; Xiaoya Xu; Yong Yu; Zishuo Chen; Xiaobing Wu; Hua Dong; Kaijian Chu; et al. (Human Cell, 2021)
Gallbladder carcinoma (GBC) is a lethal biliary tract malignant neoplasm. Patient-derived primary cancer cell lines (PDPCs) are appropriate models to explore biological characteristics and potential therapeutics; however, there is a lack of PDPCs in GBC. In this study, we aimed to establish and characterize the GBC PDPCs, and further investigated the intra-tumor heterogeneity (ITH). Multi-region sampling (3–9 regions) of the operable tumor tissue samples was used to establish PDPCs. Short tandem repeat genotyping for cell authentication and karyotyping was performed, followed by whole-exome sequencing and RNA sequencing to assess the ITH at the genetic and transcriptional levels, respectively. Thirty-eight PDPCs were successfully established from seven GBC patients and characterized. ITH was observed with a median of 38.3% mutations being heterogeneous (range, 26.6–59.4%) across all patients. Similar with other tumor types, TP53 mutations were always truncal. In addition, there were three genes, KMT2C , CDKN2A , and ARID1A , with truncal mutations in at least two patients. A median of 370 differentially expressed genes (DEGs) was identified per patient. Distinct expression patterns were observed between major histocompatibility complex (MHC) class I and II genes. We found the expression of MHC class II genes in the PDPC samples was closely regulated by CIITA , while that of MHC class I genes were not correlated with CIITA expression. The PDPCs established from GBC patients can serve as novel in vitro models to identify the ITH, which may pave a crucial molecular foundation for enhanced understanding of tumorigenesis and progression.

Effects of different types of microbial inoculants on available nitrogen and phosphorus, soil microbial community, and wheat growth in high-P soil - Yihui Chen; Shuangshuang Li; Na Liu; Huan He; Xiaoyu Cao; Cheng Lv; Ke Zhang; Jiulan Dai (Environmental Science and Pollution Research, 2021)

Di-(2-ethylhexyl) phthalate induces testicular endoplasmic reticulum stress and germ cell apoptosis in adolescent mice - Bin-Bin Zhu; Zhi-Cheng Zhang; Jian Li; Xing-Xing Gao; Yuan-Hua Chen; Hua Wang; Lan Gao; De-Xiang Xu (Environmental Science and Pollution Research, 2021)

Origin of Indian Ocean multidecadal climate variability: role of the North Atlantic Oscillation - Tiejun Xie; Jianping Li; Kaiqi Chen; Yazhou Zhang; Cheng Sun (Climate Dynamics, 2021)
The multidecadal variability of Indian Ocean sea surface temperature (IOSST) has an important impact on both the regional Indian Ocean climate and the global climate. Here, we explore multidecadal variability in the annual IOSST. Observational analysis shows that the annual IOSST multidecadal variability is not only related to the Pacific Decadal Oscillation (PDO), but also to the North Atlantic Oscillation (NAO). The NAO leads by 15–20 years the detrended annual IOSST in which the PDO signal of the same period has been removed. Further analysis reveals that the NAO leads the annual IOSST multidecadal variability through its leading effect on the Atlantic Multidecadal Oscillation (AMO). The AMO affects the vertical wind anomaly in the Indian Ocean region through the Atlantic–Indian Ocean multidecadal teleconnection (AIMT), which in turn affects the net longwave radiation in the Indian Ocean region, thus driving the annual IOSST multidecadal variability. A Hasselmann model based on NAO and PDO further verify the joint influence of the NAO and PDO on the multidecadal variability of the IOSST. A PDO-based linear model and a climate model that incorporates the NAO signal are also constructed for the annual IOSST. Results show that the climate model with the NAO signal can better simulate the annual IOSST. This again verifies that the NAO is part of the annual IOSST multidecadal variability source, indicating that the annual IOSST variability may be due to the combined influences of the NAO and PDO.

Influence of major water conservation projects on river channels and shorelines in the middle and lower reaches of the Yangtze River - Yue-hua Jiang; He-qin Cheng; Quan-ping Zhou; Yun Li; Guo-qiang Yang; Yang Jin; Shi-jia Mei; Xuan Gu; Hong Zhang (Arabian Journal of Geosciences, 2021)

Physical interactions facilitate sex change in the protogynous orange‐spotted grouper, Epinephelus coioides - Jiaxing Chen; Cheng Peng; Jingjun Huang; Herong Shi; Ling Xiao; Lin Tang; Haoran Lin; Shuisheng Li; Yong Zhang (Journal of Fish Biology, 2021)
Sex change in teleost fishes is commonly regulated by social factors. In species that exhibit protogynous sex change, such as the orange‐spotted grouper Epinephelus coioides , when the dominant males are removed from the social group, the most dominant female initiates sex change. The aim of this study was to determine the regulatory mechanisms of socially controlled sex change in E. coioides . We investigated the seasonal variation in social behaviours and sex change throughout the reproductive cycle of E. coioides , and defined the behaviour pattern of this fish during the establishment of a dominance hierarchy. The social behaviours and sex change in this fish were affected by season, and only occurred during the prebreeding season and breeding season. Therefore, a series of sensory isolation experiments was conducted during the breeding season to determine the role of physical, visual and olfactory cues in mediating socially controlled sex change. The results demonstrated that physical interactions between individuals in the social groups were crucial for the initiation and completion of sex change, whereas visual and olfactory cues alone were insufficient in stimulating sex change in dominant females. In addition, we propose that the steroid hormones 11‐ketotestosterone and cortisol are involved in regulating the initiation of socially controlled sex change.

Effect of climate zone change on energy consumption of office and residential buildings in China - Yuehao Chen; Mingcai Li; Jingfu Cao; Shanjun Cheng; Ruixue Zhang (Theoretical and Applied Climatology, 2021)

Evaluation of the efficacy and safety of hydroxychloroquine in comparison with chloroquine in moderate and severe patients with COVID-19 - Qiuyu Li; Cheng Cui; Fei Xu; Jianping Zhao; Nan Li; Haichao Li; Tianbing Wang; Hua Zhang; Na Liu; Yudong Wei; Xiaoye Niu; Yan Xu; et al. (Science China Life Sciences, 2021)

Structure of SARS-CoV-2 main protease in the apo state - Xuelan Zhou; Fanglin Zhong; Cheng Lin; Xiaohui Hu; Yan Zhang; Bing Xiong; Xiushan Yin; Jinheng Fu; Wei He; Jingjing Duan; Yang Fu; Huan Zhou; et al. (Science China Life Sciences, 2021)

Orbital-scale Asian summer monsoon variations: Paradox and exploration - Hai Cheng; Haiwei Zhang; Yanjun Cai; Zhengguo Shi; Liang Yi; Chenglong Deng; Qingzhen Hao; Youbing Peng; Ashish Sinha; Hanying Li; Jingyao Zhao; Ye Tian; et al. (Science China Earth Sciences, 2021)

Gas Flow Characteristics and Optimization of Gas Drainage Borehole Layout in Protective Coal Seam Mining: A Case Study from the Shaqu Coal Mine, Shanxi Province, China - Zhiheng Cheng; Hui Pan; Quanle Zou; Zhenhua Li; Liang Chen; Jialin Cao; Kun Zhang; Yongguo Cui (Natural Resources Research, 2021)

Perilipin 4 Protein: an Impending Target for Amyotrophic Lateral Sclerosis - Lei Zhu; Fan Hu; Cheng Li; Caixiang Zhang; Ruiwen Hang; Renshi Xu (Molecular Neurobiology, 2021)

Dietary berberine can ameliorate glucose metabolism disorder of Megalobrama amblycephala exposed to a high-carbohydrate diet - Chang He; Xiaoyan Jia; Li Zhang; Fan Gao; Weibo Jiang; Chuang Wen; Cheng Chi; Xiangfei Li; Guangzhen Jiang; Haifeng Mi; Wenbin Liu; Dingdong Zhang (Fish Physiology and Biochemistry, 2021)

Population-based meta-analysis of chloroquine: informing chloroquine pharmacokinetics in COVID-19 patients - Xueting Yao; Xiaoyu Yan; Xiaohan Wang; Ting Cai; Shun Zhang; Cheng Cui; Xiaoxu Wang; Zhe Hou; Qi Liu; Haiyan Li; Jing Lin; Zi Xiong; et al. (European Journal of Clinical Pharmacology, 2021)
Aims Chloroquine (CQ) has been repurposed to treat coronavirus disease 2019 (COVID-19). Understanding the pharmacokinetics (PK) in COVID-19 patients is essential to study its exposure–efficacy/safety relationship and provide a basis for a possible dosing regimen optimization. Subject and methods In this study, we used a population-based meta-analysis approach to develop a population PK model to characterize the CQ PK in COVID-19 patients. An open-label, single-center study (ethical review approval number: PJ-NBEY-KY-2020-063-01) was conducted to assess the safety, efficacy, and pharmacokinetics of CQ in patients with COVID-19. The sparse PK data from 50 COVID-19 patients, receiving 500 mg CQ phosphate twice daily for 7 days, were combined with additional CQ PK data from 18 publications. Results A two-compartment model with first-order oral absorption and first-order elimination and an absorption lag best described the data. Absorption rate (ka) was estimated to be 0.559 h −1 , and a lag time of absorption (ALAG) was estimated to be 0.149 h. Apparent clearance (CL/F) and apparent central volume of distribution (V2/F) was 33.3 l/h and 3630 l. Apparent distribution clearance (Q/F) and volume of distribution of peripheral compartment (Q3/F) were 58.7 l/h and 5120 l. The simulated CQ concentration under five dosing regimens of CQ phosphate were within the safety margin (400 ng/ml). Conclusion Model-based simulation using PK parameters from the COVID-19 patients shows that the concentrations under the currently recommended dosing regimen are below the safety margin for side-effects, which suggests that these dosing regimens are generally safe. The derived population PK model should allow for the assessment of pharmacokinetics–pharmacodynamics (PK-PD) relationships for CQ when given alone or in combination with other agents to treat COVID-19.

Assessing the Influence of Aerosol on Radiation and Its Roles in Planetary Boundary Layer Development - Zhigang Cheng; Yubing Pan; Ju Li; Xingcan Jia; Xinyu Zhang; Pengkun Ma; Qianqian Wang; Junxia Dou; Jingjiang Zhang; Jiannong Quan (Journal of Meteorological Research, 2021)

Levels and patterns of genetic variation in Pampus minor: Assessment of a mitochondrial DNA control region sequence - Yuan Li; Liyan Zhang; Jing Zhang; Cheng Liu; Longshan Lin (Acta Oceanologica Sinica, 2021)

Three new sesquiterpenoids with cytotoxic activity from Artemisia argyi - Li Zhang; Yong-Ming Yan; Shao-Xiang Wang; Zhe Ren; Yong-Xian Cheng (Natural Product Research, 2021)

Simulation of the fragmentation and propagation of jointed rock masses in rockslides: DEM modeling and physical experimental verification - Qi-wen Lin; Qian-Gong Cheng; Yu Xie; Feng-shou Zhang; Kun Li; Yu-feng Wang; Yuan-yuan Zhou (Landslides, 2021)

Microtubule Stabilization Promotes Microcirculation Reconstruction After Spinal Cord Injury - Yang-Yang Duan; Yong Chai; Nai-Li Zhang; Dong-Mei Zhao; Cheng Yang (Journal of Molecular Neuroscience, 2021)
Spinal cord microcirculation plays an important role in maintaining the function of spinal cord neurons and other cells. Previous studies have largely focused on the ability of microtubule stabilization to inhibit the fibroblast migration and promote axon regeneration after spinal cord injury (SCI). However, the effect of microtubule stabilization treatment on microcirculation reconstruction after SCI remains unclear. By using immunofluorescence, we found that microtubule stabilization treatment improved microcirculation reconstruction via increasing the number of microvessels, pericytes, and the perfused microvessels after SCI. To clarify the underlying mechanisms, rat brain microvascular endothelial cells and pericytes were subjected to glucose oxygen deprivation. By using flow cytometry and western blotting, we found that microtubule stabilization treatment inhibited apoptosis and migration of endothelial cells and pericytes but promoted proliferation and survival of endothelial cells and pericytes through upregulated expression of vascular endothelial growth factor A (VEGFA), VEGF receptor 2, platelet-derived growth factor-B (PDGFB), PDGF receptor β, and angiopoietin-1 after SCI. Taken together, this study provides evidence for the mechanisms underlying the promotion of microcirculation reconstruction after SCI by microtubule stabilization treatment. Importantly, this study suggests the potential of microtubule stabilization as a therapeutic target to reduce microcirculation dysfunction after SCI in the clinic.

Groundwater sources, flow patterns, and hydrochemistry of the Central Yinchuan Plain, China - Ying Li; Ping Wu; Xiao-Qin Huang; Bo Zhang; Zhao-Xiang Xu; Yang Li; Jie Li; Lu-Chen Wang; Yu-Fang Sun; Xu-Chen Meng; Cheng-Wen Wang; Zi-Zhao Cai (Hydrogeology Journal, 2021)

The metabolic and immunological characteristics of pregnant women with COVID-19 and their neonates - Jingjiao Zhou; Yudie Wang; Juan Zhao; Lixing Gu; Cheng Yang; Jun Wang; Heng Zhang; Yu Tian; Hu Tuo; Dan Li; Min Wei; Bing He (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Maternal exposure to ambient SO2 and risk of polydactyly and syndactyly: a population-based case-control study in Liaoning Province, China - Yu-Ting Jiang; Ting-Ting Gong; Jia-Yu Zhang; Yan-Hong Huang; Jing Li; Shu Liu; Yan-Ling Chen; Li-Li Li; Cheng-Zhi Jiang; Zong-Jiao Chen; Yu-Hong Zhao; Qi-Jun Wu (Environmental Science and Pollution Research, 2021)

Short-term effects of ambient temperature on preterm birth: a time-series analysis in Xuzhou, China - Peng Cheng; Lei Peng; Jingwen Hao; Sha Li; Chao Zhang; Lianjie Dou; Weinan Fu; Fan Yang; Jiahu Hao (Environmental Science and Pollution Research, 2021)

Effects of degradation succession of alpine wetland on soil organic carbon and total nitrogen in the Yellow River source zone, west China - Chun-ying Lin; Xi-lai Li; Jing Zhang; Hua-fang Sun; Juan Zhang; Hui-bang Han; Qi-hua Wang; Cheng-biao Ma; Cheng-yi Li; Yu-xing Zhang; Xue-qian Ma (Journal of Mountain Science, 2021)

Degradation stage effects on vegetation and soil properties interactions in alpine steppe - Cheng-yang Li; Fei Peng; Xian Xue; Chi-min Lai; Wen-juan Zhang; Quan-gang You; Xiao-jie Chen; Xue-qin Zhang; Tao Wang (Journal of Mountain Science, 2021)

Pseudomonas laoshanensis sp. nov., isolated from peanut field soil - Ming-Qing Wang; Chu-Shu Zhang; Li-Na Yu; Wei-Qiang Yang; Kun Jiao; Kui-Jie Gong; Xiao-Yuan Chi; Jie Bi; Yu Song; Qing-Li Yang; Jian-Cheng Zhang; Gui-Wen Yang; et al. (Archives of Microbiology, 2021)

Spatial distribution of atmospheric bioaerosols in Beijing, Hangzhou and Wuhan, China - Xuezheng Ma; Qi Zhang; Keyang Liu; Liping Zhang; Manman Zhang; Xin Zhao; Chunya Zhou; Jinke Li; Ming Cheng; Lili Li; Kongxin Hu; Jinsong Li; et al. (Aerobiologia, 2021)

The MYB transcription factor Baymax1 plays a critical role in rice male fertility - Xiao-Jiao Xiang; Lian-Ping Sun; Ping Yu; Zheng-Fu Yang; Pei-Pei Zhang; Ying-Xin Zhang; Wei-Xun Wu; Dai-Bo Chen; Xiao-Deng Zhan; Riaz-Muhammad Khan; Adil Abbas; Shi-Hua Cheng; et al. (Theoretical and Applied Genetics, 2021)

Small RNA Sequencing Analysis of Germinating Single-bud Seedcane Sett in Sugarcane - Kai-Chao Wu; Lin Xu; Zhi-Nian Deng; Tian Pang; Rong-Hua Zhang; Yi-Jie Li; Xiao-Yan Liu; Cheng-Feng Huang; Wen-Xian Qin; Jian-Feng Wei; Li-Ping Wei; Yang-Rui Li; et al. (Sugar Tech, 2021)

Estimation of rice plant potassium accumulation based on non-negative matrix factorization using hyperspectral reflectance - Jingshan Lu; Wanyu Li; Minglei Yu; Xiangbin Zhang; Yong Ma; Xi Su; Xia Yao; Tao Cheng; Yan Zhu; Weixing Cao; Yongchao Tian (Precision Agriculture, 2021)

Can phosphorus (P)-releasing bacteria and earthworm (Eisenia fetida L.) co-enhance soil P mobilization and mycorrhizal P uptake by maize (Zea mays L.)? - Junbo Liu; Junli Hu; Zhang Cheng; Minghui Li; Zihao Liu; Junhua Wang; Xiangui Lin (Journal of Soils and Sediments, 2021)

Interleukin Enhancer Binding Factor 2 Regulates Cell Viability and Apoptosis of Human Brain Vascular Smooth Muscle Cells - Liang Wei; Cheng Yang; Guangxue Wang; Keqin Li; Yanfei Zhang; Hongxin Guan; Zhiyang Sun; Chunlong Zhong (Journal of Molecular Neuroscience, 2021)

NDRG2 is expressed on enteric glia and altered in conditions of inflammation and oxygen glucose deprivation/reoxygenation - Yuxin Zhang; Hui Gao; Na Li; Haiqing Chang; Bo Cheng; Yansong Li; Jiwen Miao; Shuang Li; Qiang Wang (Journal of Molecular Histology, 2021)

Assisted selection of eating quality progeny of indica (O. sativa L. ssp. indica) and japonica (O. sativa L. ssp. japonica) hybrids using rice starch properties - Ting Mao; Zhan Zhang; Shan Jun Ni; Yi Zhou Zhao; Xin Li; Li Li Zhang; Yan Liu; Cheng Shun Zhong; He Huang; Shao Lin Wang; Xu Li (Genetic Resources and Crop Evolution, 2021)

Simultaneously decreased temporal variability and enhanced variability-strength coupling of emotional network connectivities are related to positive symptoms in patients with schizophrenia - Yanjia Deng; Shuguang Han; Dongliang Cheng; Hui Li; Bin Zhang; Youyong Kong; Yong Lin; Yingjia Li; Ge Wen; Kai Liu (Brain Imaging and Behavior, 2021)

RNA m6A methylation promotes the formation of vasculogenic mimicry in hepatocellular carcinoma via Hippo pathway - Kailiang Qiao; Yantao Liu; Zheng Xu; Haohao Zhang; Heng Zhang; Chao Zhang; Zhi Chang; Xinyan Lu; Zhongwei Li; Ce Luo; Yanrong Liu; Cheng Yang; et al. (Angiogenesis, 2021)

Insights into the aridification history of Central Asian Mountains and international conservation strategy from the endangered wild apple tree - Hong‐Xiang Zhang; Xiao‐Shuang Li; Jian‐Cheng Wang; Dao‐Yuan Zhang (Journal of Biogeography, 2021)
Aim Evolutionary processes of mountain plants in arid lands remain poorly understood. Here, we investigate population genomics of the endangered wild apple tree to interpret the effects of long‐term aridification on plant diversification and demographical history in Central Asian Mountains. Location The Tianshan Mountains, spanning north‐western China, Kazakhstan, Kyrgyzstan and Tajikistan. Taxon Malus sieversii (Rosaceae) Methods Using genome‐wide single nucleotide polymorphisms, we assessed genetic diversity and genetic structure of 15 populations across the species' range. Demographical history was simulated with approximate Bayesian computation and species distribution modelling. We used a general linear model to identify key environmental factors affecting population genetic diversity and structure. Results We separated the 15 populations into three groups: the eastern group of western Junggar Mountains in China; the central group of the Ili Valley, the Talas Alatau Mountains in Kazakhstan and Kyrgyzstan; and the western group of Tajikistan and the Dzungarian Alatau in Kazakhstan. Central populations had higher genetic diversity and effective population size than eastern and western populations. The three groups split at the late Miocene and subsequently experienced extensive admixture. We detected a significant pattern of isolation by distance, but not isolation by environment, among these populations. Population genetic diversity was significantly associated with longitudinal and current environmental gradients. Main conclusions Long‐term aridification promoted distribution fragmentation and plant lineage divergence of relict broad‐leaved forests in Central Asian Mountains. Both geographical isolation and environmental heterogeneity shaped spatial patterns in genetic variation among M. sieversii populations. To maintain genetic integrity, we propose the establishment of an international network for the conservation of this endangered wild apple tree.

Construction and characterization of UAA-controlled recombinant Zika virus by genetic code expansion - Rong-Rong Zhang; Qing Ye; Xiao-Feng Li; Yong-Qiang Deng; Yan-Peng Xu; Xing-Yao Huang; Qing Xia; Cheng-Feng Qin (Science China Life Sciences, 2021)

Comparative genomic analysis of superoxide dismutase (SOD) genes in three Rosaceae species and expression analysis in Pyrus bretschneideri - Guohui Li; Fei Hu; Yang Zhang; Yu Zhao; Han Wang; Tianzhe Chen; Xi Cheng; Yongping Cai (Physiology and Molecular Biology of Plants, 2021)

Effects of Different Component Contents of Colistin Methanesulfonate on the Pharmacokinetics of Prodrug and Formed Colistin in Human - Ya-Xin Fan; Yuan-Cheng Chen; Yi Li; Ji-Cheng Yu; Xing-Chen Bian; Xin Li; Wan-Zhen Li; Bei-Ning Guo; Hai-Lan Wu; Xiao-Fen Liu; Yu Wang; Xiao-Yong Xu; et al. (Pharmaceutical Research, 2021)

Isoflurane promotes proliferation of squamous cervical cancer cells through mTOR-histone deacetylase 6 pathway - Wenwen Zhang; Fang Xue; Shangdan Xie; Cheng Chen; Jingwei Li; Xueqiong Zhu (Molecular and Cellular Biochemistry, 2021)
This study investigated the effect of isoflurane on the proliferation of squamous cervical cancer cells, with focus on histone deacetylase 6 that is closely related to carcinogenesis. Squamous cervical cancer cells SiHa and Caski were exposed to 1%, 2%, or 3% isoflurane for 2 h, respectively. Cell proliferation was measured with the cell counting kit (CCK-8) assay and determined by BrdU assay. Expression of histone deacetylase 6, phospho-AKT, phospho-mTOR, and proliferating cell nuclear antigen (PCNA) was assessed by Western blot. In order to block the histone deacetylase 6 (HDAC6) expression, siRNA transfection was performed. Isoflurane significantly promoted the proliferation of both SiHa and Caski cells, accompanied by upregulation of PCNA protein expression. Isoflurane increased the level of histone deacetylase 6 protein expression in both cells, and knockdown of histone deacetylase 6 attenuated the pro-proliferation effects of isoflurane. Additionally, activation of AKT/mTOR was found after isoflurane treatment, and mTOR inhibition abolished isoflurane-induced histone deacetylase 6 expression. However, inhibition of AKT phosphorylation had no effect on the expression of histone deacetylase 6 mediated by isoflurane. In conclusion, Isoflurane enhanced proliferation of cervical cancer cells through upregulation of histone deacetylase 6, which was associated with mTOR-dependent pathway, but not AKT-mediated pathway.

High bioremediation potential of strain Chenggangzhangella methanolivorans CHL1 for soil polluted with metsulfuron-methyl or tribenuron-methyl in a pot experiment - Ting-Ting Yang; Hui-Wen Zhang; Jian Wang; Xin-Yu Li; Xu Li; Zhen-Cheng Su (Environmental Science and Pollution Research, 2021)

Strategic interactions in environmental regulation enforcement: evidence from Chinese cities - Kangkang Zhang; Deyi Xu; Shiran Li; Ting Wu; Jinhua Cheng (Environmental Science and Pollution Research, 2021)

The short-term effect of PM2.5/O3 on daily mortality from 2013 to 2018 in Hefei, China - Xinmiao Sui; Junqing Zhang; Qi Zhang; Shu Sun; Ruoqian Lei; Chao Zhang; Han Cheng; Liu Ding; Rui Ding; Changchun Xiao; Xiaoru Li; Jiyu Cao (Environmental Geochemistry and Health, 2021)

On the connection between AMOC and observed land precipitation in Northern Hemisphere: a comparison of the AMOC indicators - Jing Zhang; Yusen Liu; Cheng Sun; Jianping Li; Ruiqiang Ding; Fei Xie; Tiejun Xie; Yazhou Zhang; Zhanqiu Gong (Climate Dynamics, 2021)

Soil Threshold Values for Zn Based on Soil-Rice System and Health Risk Assessment in a Typical Carbonate Area of Guangxi - Yizheng Wang; Zhongfang Yang; Junfeng Ji; Qiong Yang; Xu Liu; Cheng Li; Wenbing Ji; Hongze Bo; Qizuan Zhang; Xiaoxiong Zhuo; Lei Wang (Bulletin of Environmental Contamination and Toxicology, 2021)

A Study on Hair Mercury Levels of University Students - Yurong Wu; Jinping Xue; Cheng Zhang; Li Liang; Yongmin Wang; Dingyong Wang (Bulletin of Environmental Contamination and Toxicology, 2021)

Screening and identification of a specific peptide binding to breast cancer cells from a phage-displayed peptide library - Huijuan Jin; Xiaojie Gao; Li Xiao; Huimin He; Sinan Cheng; Caixia Zhang; Yifan Hou; Fengying Song; Xiaorong Su; Qian Gao; Zheng Lu; Ruina Yang; et al. (Biotechnology Letters, 2021)

Progress and prospects of applied research on physical geography and the living environment in China over the past 70 years (1949–2019) - Fahu Chen; Shaohong Wu; Peng Cui; Yunlong Cai; Yili Zhang; Yunhe Yin; Guobin Liu; Zhu Ouyang; Wei Ma; Linsheng Yang; Duo Wu; Jiaqiang Lei; et al. (Journal of Geographical Sciences, 2021)

Improving the observation and prediction capabilities for Arctic marine environment: from the perspective of Arctic Shipping - Hui Wang; Qizhen Sun; Lin Zhang; Xi Liang; Qinghua Yang; Na Liu; Chunhua Li; Qingsheng Liu; Bingrui Li; Qian Feng; Xiao Cheng; Yi Yu (Acta Oceanologica Sinica, 2021)

Atlantic Meridional Overturning Circulation reconstructions and instrumentally observed multidecadal climate variability: A comparison of indicators - Cheng Sun; Jing Zhang; Xiang Li; Chunming Shi; Zhanqiu Gong; Ruiqiang Ding; Fei Xie; Panxing Lou (International Journal of Climatology, 2021)
The Atlantic Meridional Overturning Circulation (AMOC) has an important role in the Earth's climate system, but it remains unclear how the instrumentally observed multidecadal variability of the Earth's climate is related to the AMOC. We carried out a comprehensive evaluation of five representative indicators of the AMOC, including one atmospheric index based on the effect of accumulated atmospheric forcing on the AMOC and four oceanographic indices using surface and subsurface oceanographic variables in the North Atlantic Ocean. We compared reconstructions of the AMOC against measurement records and analysed the relationships with the multidecadal variability of the annual mean surface air temperature anomalies over the North Atlantic, Northern Hemisphere and South Atlantic. All the AMOC indicators show a weakening trend during the most recent decade, which is in good agreement with the RAPID measurement record of the AMOC. Besides, the atmospheric reconstruction shows the best agreement with the observed low‐frequency variation in the AMOC since 2004. The multidecadal variability in hemispheric/regional surface temperatures is closely related to all the AMOC reconstructions and opposite relationships are observed between the North Atlantic and South Atlantic oceans. The multidecadal surface air temperature anomalies associated with the variations in the AMOC are most pronounced for the atmospheric reconstruction index, which leads the variations in the surface air temperature by 4–5 years. Among the oceanographic indicators, the reconstructions using subsurface oceanographic variables performed best in terms of the relationship with the variations in the multidecadal surface air temperature.

Phytochemical and antitumor studies on Cynanchum mongolicum (Maxim.) Kom - Yong-Cheng Yang; Yan-Ming Wang; Zi-Jian Rong; Li-Na Hong; Qian Zhang; Jing-Ming Jia; An-Hua Wang (Natural Product Research, 2020)

Antidumping Duty Investigations and Decisions in the Global Forest Products Industry - Xufang Zhang; Changyou Sun; Jason Gordon; Cheng Li; Ian A Munn (Forest Science, 2020)
Special tariffs have been increasingly adopted to protect domestic industries from potential injury caused by unfair international trade. In this study, a multinomial logit model is employed to examine the patterns and determinants of antidumping duty investigations in the global forest products industry. From 1995 to 2015, a total of 372 relevant cases are identified. The number of firms and the inclusion of unions as a petitioner generally improve the probability of an affirmative decision. The characteristics of petition countries have shown more impacts on the decisions than those of target countries. Developing countries have initiated a larger number of antidumping duty investigations in the global forest products industry, and furthermore, they are more inclined to adopt antidumping duties than developed countries. Countries with abundant forest resources and more forest products trade are more likely to make an affirmative decision. These findings will provide helpful information to industrial firms and government agencies in dealing with the challenges of global competition. Study Implications The findings reveal that getting more stakeholders involved in an antidumping duty investigation will increase the probability of trade intervention. The economic status in petition countries is the primary determinant of the decisions from antidumping duty investigations in the global forest products industry. Developing countries not only have initiated a large number of antidumping duty investigations in the forest products industry but also have been more inclined to adopt antidumping duties. Antidumping duty investigations offer an opportunity to countries with abundant forest resources and extensive forest products trade in case of unfair international competition.

Mapping quantitative trait loci associated with stem-related traits in maize (Zea mays L.) - Qiqi Shang; Degui Zhang; Rong Li; Kaixin Wang; Zimeng Cheng; Zhiqiang Zhou; Zhuanfang Hao; Jinbao Pan; Xinhai Li; Liyu Shi (Plant Molecular Biology, 2020)

Assessing SARS-CoV-2 RNA levels and lymphocyte/T cell counts in COVID-19 patients revealed initial immune status as a major determinant of disease severity - Mingfeng Han; Mengyuan Xu; Yafei Zhang; Zhongping Liu; Shasha Li; Tengfei He; Jinsong Li; Yong Gao; Wanjun Liu; Tuantuan Li; Zixiang Chen; Xin Huang; et al. (Medical Microbiology and Immunology, 2020)

Clinical characteristics and plasma antibody titer of patients with COVID-19 in Zhejiang, China - Wei-ling Xiang; Jing-jing Cheng; Lian-peng Wu; Bing-yu Chen; Wen-xin Li; Dan-ying Qiu; Wei Zhang; Fei-hang Ge; Dong Chen; Zhen Wang (Journal of Zhejiang University-SCIENCE B, 2020)

A New Endoplasmic Reticulum (ER)-Targeting Fluorescent Probe for the Imaging of Cysteine in Living Cells - Lei Zhou; Yunxia Li; Aiqin Zhou; Guanghui Zhang; Zhi-Qiang Cheng; Yong-Xi Ge; Shan-Kui Liu; Ricardo Bentes Azevedo; Juan Zhang; Shenglin Jiang; Cheng-Shi Jiang (Journal of Fluorescence, 2020)

High-throughput sequencing reveals the molecular mechanisms determining the stay-green characteristic in soybeans - Cheng Wang; Le Gao; Run Zhi Li; Ye Wang; Yang Ying Liu; Xin Zhang; Hao Xie (Journal of Biosciences, 2020)

The Effect of Atractylodes macrocephala Polysaccharides on Rabbit’s Host Defense Peptide (RSRAH) mRNA Expression - Guihua Fu; Yang Zhang; Yinglun Li; Xing He; Xiaofen Li; Peng Cheng; Hongwei Chen (International Journal of Peptide Research and Therapeutics, 2020)

Effect on intestinal microbiota, bioaccumulation, and oxidative stress of Carassius auratus gibelio under waterborne cadmium exposure - Nan Wang; Zhengyao Guo; Yilin Zhang; Peijun Zhang; Jia Liu; Yi Cheng; Lei Zhang; Yuehong Li (Fish Physiology and Biochemistry, 2020)

Correction to: Ligninolytic enzyme involved in removal of high molecular weight polycyclic aromatic hydrocarbons by Fusarium strain ZH-H2 - Xiaoxue Zhang; Xiaomin Wang; Cheng Li; Lixiu Zhang; Guohui Ning; Wei Shi; Xuena Zhang; Zhixin Yang (Environmental Science and Pollution Research, 2020)

Ligninolytic enzyme involved in removal of high molecular weight polycyclic aromatic hydrocarbons by Fusarium strain ZH-H2 - Xiaoxue Zhang; Xiaomin Wang; Cheng Li; Lixiu Zhang; Guohui Ning; Wei Shi; Xuena Zhang; Zhixin Yang (Environmental Science and Pollution Research, 2020)

Identification of hybrid green peafowl using mitochondrial and nuclear markers - Han Yu Du; Xin Yuan Zhang; Thi Dao Dinh; Yue Ma; Cheng Zong; Guang Long Li; Thomas D. Dahmer; Yan Chun Xu (Conservation Genetics Resources, 2020)

Sulfide ore prospecting in carbon-containing stratum using comprehensive time-domain induced polarization and controlled-source audio-frequency magnetotellurics - Ren-Bin Sun; Li-Xia Chu; Gui-Bin Zhang; Qiu-Ming Cheng; Yun-Chuan Xiang; Bin Hu; Chang-Rong Zhang; Jian-Fu Li; Yi-Jun Zhao (Applied Geophysics, 2020)

Sphingosylphosphorylcholine alleviates hypoxia-caused apoptosis in cardiac myofibroblasts via CaM/p38/STAT3 pathway - Ying Li; Qi Qi; Wan-cheng Yang; Tian-liang Zhang; Chen-chen Lu; Yu-juan Yao; Wei-hua Kong; Jing Zhao (Apoptosis, 2020)

The complete mitochondrial genome of the hybrid grouper Epinephelus moara (♀)×Epinephelus tukula (♂), and phylogenetic analysis in subfamily Epinephelinae - Zhentong Li; Yongsheng Tian; Meiling Cheng; Linna Wang; Jingjing Zhang; Yuping Wu; Zunfang Pang; Wenhui Ma; Jieming Zhai (Acta Oceanologica Sinica, 2020)

Regional drivers of diversification in the late Quaternary in a widely distributed generalist species, the common pheasant Phasianus colchicus - Simin Liu; Yang Liu; Edouard Jelen; Mansour Alibadian; Cheng‐Te Yao; Xintong Li; Nasrin Kayvanfar; Yutao Wang; Farhad S. M. Vahidi; Jian‐Lin Han; Gombobaatar Sundev; Zhengwang Zhang; et al. (Journal of Biogeography, 2020)
Aim Pleistocene climate and associated environmental changes have influenced phylogeographic patterns of many species. These not only depend on a species’ life history but also vary regionally. Consequently, populations of widespread species that occur in several biomes might display different evolutionary trajectories. We aimed to identify regional drivers of diversification in the common pheasant, a widely distributed ecological generalist. Location Asia. Taxon Common pheasant Phasianus colchicus . Methods Using a comprehensive geographical sampling of 204 individuals from the species’ entire range genotyped at seven nuclear and two mitochondrial loci, we reconstructed spatio‐temporal diversification and demographic history of the common pheasant. We applied Bayesian phylogenetic inference to describe phylogeographic structure, generated a species tree and inferred demographic history within and migration between lineages. Moreover, to establish a taxonomic framework, we conducted a species delimitation analysis. Results The common pheasant diversified during the Late Pleistocene into eight distinct lineages. It originated at the edge of the Qinghai–Tibetan plateau and spread to East and Central Asia. Only the widely distributed lowland lineage of East Asia displayed recent range expansion. Greater phylogeographic structure was identified elsewhere, with lineages showing no sign of recent demographic changes. One lineage in south‐central China is the result of long‐term isolation within a climatically stable but topographically complex region. In lineages from arid Central Asia and China, range expansions were impeded by repeated population fragmentation during dry glacial periods and by recent aridification. Main conclusions Spatio‐temporal phylogeographic frameworks of widespread taxa such as the common pheasant provide valuable opportunities to identify divergent drivers of regional diversification. Our results suggest that diversification and population histories in the eight distinct evolutionary lineages were shaped by regionally variable effects of past climate and associated environmental changes. The evolutionary history of the common pheasant is best reflected by its being split into three species.

An A 1 -type granite that borders A 2 -type: insights from the geochemical characteristics of the Zongyang A-type granite in the Lower Yangtze River Belt, China - Xiao-Yan Jiang; Kai Wu; Jin-Cheng Luo; Li-Peng Zhang; Wei Dong Sun; Xiao-Ping Xia (International Geology Review, 2020)

Environmentally responsive QTL controlling surface wax load in switchgrass - Jennifer Bragg; Pernell Tomasi; Li Zhang; Tina Williams; Delilah Wood; John T. Lovell; Adam Healey; Jeremy Schmutz; Jason E. Bonnette; Prisca Cheng; Lisa Chanbusarakum; Thomas Juenger; et al. (Theoretical and Applied Genetics, 2020)

Analysis of genetic architecture and favorable allele usage of agronomic traits in a large collection of Chinese rice accessions - Xiuxiu Li; Zhuo Chen; Guomin Zhang; Hongwei Lu; Peng Qin; Ming Qi; Ying Yu; Bingke Jiao; Xianfeng Zhao; Qiang Gao; Hao Wang; Yunyu Wu; et al. (Science China Life Sciences, 2020)

WDR5a functions in cadmium-inhibited root meristem growth by regulating nitric oxide accumulation in Arabidopsis - Yu Zhang; Yang-Yang Tian; Lin-Feng Wang; Yun-Hui Li; Ting-Ting Li; Wen-Cheng Liu (Planta, 2020)

Lagged response of Adélie penguin (Pygoscelis adeliae) abundance to environmental variability in the Ross Sea, Antarctica - Xintong Chen; Xiao Cheng; Baogang Zhang; Hao Meng; Di Wu; Miao Zhang; Ming Ji; Xianglan Li (Polar Biology, 2020)

Identification of AP2/ERF genes in apple (Malus × domestica) and demonstration that MdERF017 enhances iron deficiency tolerance - Li Cheng; Tong Zhao; Yu-Xia Wu; Hai Wang; Zhong-Xing Zhang; De Zhang; Shuang-Cheng Wang; Yan-Xiu Wang (Plant Cell, Tissue and Organ Culture (PCTOC), 2020)

The effect of blastomere loss during frozen embryo transfer on the transcriptome of offspring’s umbilical cord blood - Yan-Ting Wu; Ze-Han Dong; Cheng Li; Dai-Zhan Zhou; Jun-Yu Zhang; Yan Wu; Jing-Jing Xu; Yu Wang; Xiao-Qun Ye; Jian-Zhong Sheng; Li Wang; He-Feng Huang (Molecular Biology Reports, 2020)

Correction to: Genome-wide characterization of the cellulose synthase gene superfamily in Pyrus bretschneideri and reveal its potential role in stone cell formation - Guohui Li; Xin Liu; Yuxuan Liang; Yang Zhang; Xi Cheng; Yongping Cai (Functional & Integrative Genomics, 2020)

Water quality assessment and pollution source apportionment using multi-statistic and APCS-MLR modeling techniques in Min River Basin, China - Han Zhang; Hongfei Li; Haoran Yu; Siqian Cheng (Environmental Science and Pollution Research, 2020)

Combined effects of di (2-ethylhexyl) phthalate and bisphenol A on thyroid hormone homeostasis in adolescent female rats - Xuan Zhang; Yuejiao Zhao; Cheng Cheng; Liuli Li; Mingyang Xiao; Guopei Zhang; Xiaobo Lu (Environmental Science and Pollution Research, 2020)

Whether the carbon emission from green roofs can be effectively mitigated by recycling waste building material as green roof substrate during five-year operation? - Liangqian Fan; Jingting Wang; Xiaoling Liu; Hongbing Luo; Ke Zhang; Xiaoying Fu; Mei Li; Xiaoting Li; Bing Jiang; Jia Chen; Shuzhi Fu; You Mo; et al. (Environmental Science and Pollution Research, 2020)

Predicting the spatiotemporal characteristics of flash droughts with downscaled CMIP5 models in the Jinghe River basin of China - Hui Ran; Jing Li; Zixiang Zhou; Cheng Zhang; Chengyan Tang; Yuyang Yu (Environmental Science and Pollution Research, 2020)

Assimilation of exogenous cyanide cross talk in Oryza sativa L. to the key nodes in nitrogen metabolism - Cheng-Zhi Li; Li Yang; Yu-Juan Lin; Hua Zhang; Saeed Rad; Xiao-Zhang Yu (Ecotoxicology, 2020)

How do Biotic and Abiotic Factors Regulate Soil Enzyme Activities at Plot and Microplot Scales Under Afforestation? - Qianxi Li; Ji Chen; Jiao Feng; Junjun Wu; Qian Zhang; Wei Jia; Qiaoling Lin; Xiaoli Cheng (Ecosystems, 2020)

Identification and Characterization of the Nuclease Activity of the Extracellular Proteins from Salmonella enterica Serovar Typhimurium - Chengshui Liao; Mengke Zhang; Xiangchao Cheng; Qi Li; Fuchao Mao; Xiaoli Wang; Chuan Yu; Zuhua Yu; Yanyan Jia; Jing Li; Lei He; Chunjie Zhang; et al. (Current Microbiology, 2020)

Antibacterial effect of Blumea balsamifera DC. essential oil against Haemophilus parasuis - Changliang He; Peiyi Yang; Lu Wang; Xiaolin Jiang; Wei Zhang; Xiaoxia Liang; Lizi Yin; Zhongqiong Yin; Yi Geng; Zhijun Zhong; Xu Song; Yuanfeng Zou; et al. (Archives of Microbiology, 2020)

Molecular Mobility and Crystal Growth in Amorphous Binary Drug Delivery Systems: Effects of Low-Concentration Poly(Ethylene Oxide) - Qin Shi; Jin Cheng; Fang Li; Jia Xu; Chen Zhang (AAPS PharmSciTech, 2020)

Snapshot of Peptidomics of the Red Tide Forming Species Noctiluca scintillans - Shuwen Zhang; Cheng Li; Shunyan Cheung; Mingming Sun; Shuqun Song; Wang Guo; Cui Guo; Gongguo Wu; Hongbin Liu (Frontiers in Marine Science, 2020)

Chemical constituents from Glehnia littoralis and their chemotaxonomic significance - Shouwen Zhang; Fang Cheng; Li Yang; Jinxiang Zeng; Fengyu Han; Xiuling Yu; Yuye Zhu; Guoyue Zhong; Junwei He (Natural Product Research, 2020)

Synergistic mutations of two rapeseed AHAS genes confer high resistance to sulfonylurea herbicides for weed control - Yue Guo; Li Cheng; Weihua Long; Jianqin Gao; Jiefu Zhang; Song Chen; Huiming Pu; Maolong Hu (Theoretical and Applied Genetics, 2020)

Liquiritin inhibits proliferation and induces apoptosis in HepG2 hepatocellular carcinoma cells via the ROS-mediated MAPK/AKT/NF-κB signaling pathway - Jia-Ru Wang; Tian-Zhu Li; Cheng Wang; Shu-Mei Li; Ying-Hua Luo; Xian-Ji Piao; Yu-Chao Feng; Yi Zhang; Wan-Ting Xu; Yu Zhang; Tong Zhang; Shi-Nong Wang; et al. (Naunyn-Schmiedeberg's Archives of Pharmacology, 2020)

Inclination effect of coal mine strata on the stability of loess land slope under the condition of underground mining - Xue-yang Sun; Chun-Hsing Ho; Cheng Li; Yucheng Xia; Qi Zhang (Natural Hazards, 2020)

Overexpression of PREX1 in oral squamous cell carcinoma indicates poor prognosis - Shu-Cheng Wan; Hao Wu; Hao Li; Wei-Wei Deng; Yao Xiao; Cong-Cong Wu; Lei-Lei Yang; Wen-Feng Zhang; Zhi-Jun Sun (Journal of Molecular Histology, 2020)

Composting pig manure and sawdust with urease inhibitor: succession of nitrogen functional genes and bacterial community - Jishao Jiang; Yang Wang; Fengqi Guo; Xiaofang Zhang; Wei Dong; Xindan Zhang; Xin Zhang; Chunyan Zhang; Ke Cheng; Yunbei Li; Guifen Zhu (Environmental Science and Pollution Research, 2020)

A robust relationship between multidecadal global warming rate variations and the Atlantic Multidecadal Variability - Zhiyu Li; Wenjun Zhang; Fei-Fei Jin; Malte F. Stuecker; Cheng Sun; Aaron F. Z. Levine; Haiming Xu; Chao Liu (Climate Dynamics, 2020)

COMT-Val158Met polymorphism modulates antipsychotic effects on auditory verbal hallucinations and temporal lobe gray matter volumes in healthy individuals—symptom relief accompanied by worrisome volume reductions - Chuanjun Zhuo; Langlang Cheng; Gongying Li; Yong Xu; Rixing Jing; Shen Li; Li Zhang; Xiaodong Lin; Chunhua Zhou (Brain Imaging and Behavior, 2020)
Investigation of auditory verbal hallucinations (AVHs) in schizophrenics is complicated by psychiatric symptoms. Investigating healthy individuals with AVHs (H-AVHs) can obviate such confounding factors. The objective of this study was to explore the effects of antipsychotic treatment on AVHs and gray matter volumes (GMVs) in H-AVH subjects and whether such are effects are influenced by COMT - Val158Met genotype. Magnetic resonance imaging (MRI) and genotyping studies were completed for 42 H-AVH subjects and 42 well-matched healthy controls (HCs). COMT-Met/Met homozygotes (158th codon) were identified as COMT-Met genotype; COMT-Met/Val heterozygotes and COMT-Val/Val homozygotes were identified as COMT-Val genotype. Data were compared across groups (H-AVH vs. HC, and between genotypes) with two-sample t-tests. The H-AVH COMT-Met group showed a stronger response to antipsychotic treatment than the H-AVH COMT-Val group ( p < 0.001). Both H-AVH genotype groups exhibited temporal lobe GMV reductions after treatment, and relative to their respective genotype-matched HC groups. Antipsychotic treatment effects in H-AVH subjects were influenced by COMT-Val158Met genotype and associated with widespread GMV reductions. These findings provide clues for further exploration of treatment targets for AVHs. Treatment associated GMV reductions, however, raise concerns about use of antipsychotics in H-AVH subjects.

Aberrant resting-state functional connectivity of salience network in first-episode schizophrenia - Huan Huang; Zeng Botao; Yuchao Jiang; Yingying Tang; Tianhong Zhang; Xiaochen Tang; Lihua Xu; Junjie Wang; Jin Li; Zhenying Qian; Xu Liu; Huiling Wang; et al. (Brain Imaging and Behavior, 2020)

Comparing GWAS and Brain Structure-Specific Gene Expression Profiles Identifies Psychiatric Disorder-Related Brain Structures at Different Developmental Stages - Xin Qi; Cuiyan Wu; Yanan Du; Shiqiang Cheng; Yan Wen; Mei Ma; Chujun Liang; Li Liu; Bolun Cheng; Lu Zhang; Ping Li; Feng Zhang (Neuroscience Bulletin, 2020)

Overexpression miR-486-3p Promoted by Allicin Enhances Temozolomide Sensitivity in Glioblastoma Via Targeting MGMT - Henggang Wu; Xu Li; Tiehui Zhang; Guojun Zhang; Jingnan Chen; Li Chen; Min He; Bilie Hao; Cheng Wang (NeuroMolecular Medicine, 2020)
Glioblastoma is the most common primary tumor of the central nervous system that develops chemotherapy resistance. Previous studies showed that Allicin could inhibit multiple cancer cells including glioblastoma, but the function of Allicin in glioblastoma is still unclear. Our work aimed to investigate the underlying molecular mechanism. The results showed that miR-486-3p levels were greatly increased in glioblastoma during Allicin treatment. Overexpression of miR-486-3p increased chemosensitivity to temozolomide (TMZ) in vitro and in vivo. O6-methylguanine-DNA methyltransferase (MGMT) was identified as a direct target of miR-486-3p, and miR-486-3p overexpression prevented the protein translation of MGMT. Moreover, overexpression of MGMT restored miR-486-3p-induced chemosensitivity to TMZ. Taken together, our studies revealed that Allicin could upregulate miR-486-3p and enhance TMZ sensitivity in glioblastoma. The results suggested that in the future, Allicin can be used as an adjuvant therapy with TMZ to improve the prognosis of patients, and miR-486-3p may be a potential target for glioblastoma treatment to improve the curative effects.

Fully multi-target segmentation for breast ultrasound image based on fully convolutional network - Yingtao Zhang; Yan Liu; Hengda Cheng; Ziyao Li; Cong Liu (Medical & Biological Engineering & Computing, 2020)

Genome-wide characterization of the cellulose synthase gene superfamily in Pyrus bretschneideri and reveal its potential role in stone cell formation - Guohui Li; Xin Liu; Yuxuan Liang; Yang Zhang; Xi Cheng; Yongping Cai (Functional & Integrative Genomics, 2020)

Natural sex change in mature protogynous orange‐spotted grouper ( Epinephelus coioides ): gonadal restructuring, sex hormone shifts and gene profiles - Cheng Peng; Qing Wang; Herong Shi; Jiaxing Chen; Shuisheng Li; Huihong Zhao; Haoran Lin; Jianchun Yang; Yong Zhang (Journal of Fish Biology, 2020)
Sexual patterns of teleosts are extremely diverse and include both gonochorism and hermaphroditism. As a protogynous hermaphroditic fish, all orange‐spotted groupers ( Epinephelus coioides ) develop directly into females, and some individuals change sex to become functional males later in life. This study investigated gonadal restructuring, shifts in sex hormone levels and gene profiles of cultured mature female groupers during the first (main) breeding season of 2019 in Huizhou, China (22° 42′ 02.6″ N, 114° 32′ 10.1″ E). Analysis of gonadal restructuring revealed that females with pre‐vitellogenic ovaries underwent vitellogenesis, spawning and regression and then returned to the pre‐vitellogenic stage in the late breeding season, at which point some changed sex to become males via the intersex gonad stage. A significant decrease in the level of serum 17 β ‐estradiol (E2) was observed during ovary regression but not during sex change, whereas serum 11‐ketotestosterone (11‐KT) concentrations increased significantly during sex change with the highest concentration in newly developed males. Consistent with serum hormone changes, a significant decrease in cyp19a1a expression was observed during ovary regression but not during sex change, whereas the expression of cyp11c1 and hsd11b2 increased significantly during sex change. Interestingly, hsd11b2 but not cyp11c1 was significantly upregulated from the pre‐vitellogenic ovary stage to the early intersex gonad stage. These results suggest that a decrease in serum E2 concentration and downregulation of cyp19a1a expression are not necessary to trigger the female‐to‐male transformation, whereas increased 11‐KT concentration and upregulation of hsd11b2 expression may be key events for the initiation of sex change in the orange‐spotted grouper.

Comparing Subsurface Seasonal Deoxygenation and Acidification in the Yellow Sea and Northern East China Sea Along the North-to-South Latitude Gradient - Tian-qi Xiong; Qin-sheng Wei; Wei-dong Zhai; Cheng-long Li; Song-yin Wang; Yi-xing Zhang; Shuo-jiang Liu; Si-qing Yu (Frontiers in Marine Science, 2020)

Physiological and transcriptomic analyses of brassinosteroid function in moso bamboo (Phyllostachys edulis) seedlings - Zhe Zhang; Xuelian Yang; Ling Cheng; Zejun Guo; Huiyuan Wang; Weihuang Wu; Kihye Shin; Jinyao Zhu; Xiaoli Zheng; Jianghu Bian; Yangchen Li; Lianfeng Gu; et al. (Planta, 2020)

Neonatal Exposure to Anesthesia Leads to Cognitive Deficits in Old Age: Prevention with Intranasal Administration of Insulin in Mice - Chun-Ling Dai; Hengchang Li; Xin Hu; Jin Zhang; Fei Liu; Khalid Iqbal; Cheng-Xin Gong (Neurotoxicity Research, 2020)

Blockade of HCN2 Channels Provides Neuroprotection Against Ischemic Injury via Accelerating Autophagic Degradation in Hippocampal Neurons - Cheng Chen; Li Liu; Ya-Qiao Shu; Ping Jing; Yun Lu; Xiao-Xue Zhang; Xian-Gang Zong; Lian-Jun Guo; Chang-Jun Li (Neuroscience Bulletin, 2020)

Glutathione S-transferase genes in scallops and their diverse expression patterns after exposure to PST-producing dinoflagellates - Jiarun Lou; Jie Cheng; Xiaogang Xun; Xu Li; Moli Li; Xiangchao Zhang; Tingting Li; Zhenmin Bao; Xiaoli Hu (Marine Life Science & Technology, 2020)

Nakamurella albus sp. nov.: A Novel Actinobacterium Isolated from a Lichen Sample - Long-Qian Jiang; De-Feng An; Kun Zhang; Gui-Ding Li; Xin-Yu Wang; Lei Lang; Ming-Guo Jiang; Li-Song Wang; Cheng-Lin Jiang; Yi Jiang (Current Microbiology, 2020)

Bacomics: a comprehensive cross area originating in the studies of various brain–apparatus conversations - Dezhong Yao; Yangsong Zhang; Tiejun Liu; Peng Xu; Diankun Gong; Jing Lu; Yang Xia; Cheng Luo; Daqing Guo; Li Dong; Yongxiu Lai; Ke Chen; et al. (Cognitive Neurodynamics, 2020)

Model test of the combined subgrade treatment by hydraulic sand fills and soil-cement mixing piles - Yang Sun; Jiu Cheng; Yiwei Li; Qi Chen; Wei Zhang; Guojian Shao (Bulletin of Engineering Geology and the Environment, 2020)

Naphthalene exerts non-target effects on the abundance of active fungi by stimulating basidiomycete abundance - Li-ying Lan; Li Zhang; Ya Shen; Jian Zhang; Wan-qin Yang; Zhen-feng Xu; Yang Liu; Shu-qin He; Wei Zhou; Han Li; Li-xia Wang; Si-ning Liu; et al. (Journal of Mountain Science, 2020)

Annual Characteristics, Source Analysis of PM1-Bound Potentially Harmful Elements in the Eastern District of Chengdu, China - Jinjin Wang; Yi Huang; Ting Li; Huibin Shi; Min He; Xin Cheng; Shijun Ni; Chengjiang Zhang (Archives of Environmental Contamination and Toxicology, 2020)

Composition, Distribution, and Assembly Patterns of Eukaryotic Communities Under Vertical Geochemical Gradients in a Polluted Urban River - Wei Cai; Yi Li; Wenlong Zhang; Lihua Niu; Longfei Wang; Haomiao Cheng (Water, Air, & Soil Pollution, 2020)

Correlation Between CCG Polymorphisms and CAG Repeats During Germline Transmission in Chinese Patients with Huntington’s Disease - Hong-Rong Cheng; Xiao-Yan Li; Hui-Li Yu; Miao Xu; Yan-Bin Zhang; Shi-Rui Gan; Hong-Lei Li; Zhi-Ying Wu (Neuroscience Bulletin, 2020)

Genetic analysis of germinating ability under alkaline and neutral salt stress by a high-density bin genetic map in rice - Xin Luo; Haodong Deng; Peng Wang; Xiangyu Zhang; Caijing Li; Cuijuan Li; Jingai Tan; Guangliang Wu; Yanning Wang; Qin Cheng; Haohua He; Jianmin Bian (Euphytica, 2020)

Source apportionment and health risk assessment of air pollution particles in eastern district of Chengdu - Yi Huang; Li Wang; Shipeng Zhang; Meng Zhang; Jinjin Wang; Xin Cheng; Ting Li; Min He; Shijun Ni (Environmental Geochemistry and Health, 2020)

Effect of Titanium Dioxide Nanoparticles on the Resistance of Silkworm to Cytoplasmic Polyhedrosis Virus in Bombyx mori - Guodong Zhao; Xiao Zhang; Jialu Cheng; Xin Huang; Heying Qian; Gang Li; Anying Xu (Biological Trace Element Research, 2020)

First detection and genomic characteristics of bovine torovirus in dairy calves in China - Hao Li; Bin Zhang; Hua Yue; Cheng Tang (Archives of Virology, 2020)

Sesquiterpene lactones from Artemisia austroyunnanensis suppresses ROS production and reduces cytokines, iNOS and COX-2 levels via NF-KB pathway in vitro - Lan Liu; Dan Liu; Cheng Xiang; Weifeng Dai; Baocai Li; Mi Zhang (Natural Product Research, 2020)

DhLHY, a Circadian Expressed Gene of Doritaenopsis Hybrid, Promotes Floral Transition in Low Temperature, but Postpones Flowering in Overexpressed Transgenic Arabidopsis - Chi Zhang; Qian Cheng; Haiyan Li; Ping Luo; Yongyi Cui (Tropical Plant Biology, 2020)

Genetic architecture of leaf morphological and physiological traits in a Populus deltoides ‘Danhong’ × P. simonii ‘Tongliao1’ pedigree revealed by quantitative trait locus analysis - Pei Sun; Huixia Jia; Xingqi Cheng; Yahong Zhang; Jianbo Li; Lei Zhang; Mengzhu Lu; Jin Zhang; Jianjun Hu (Tree Genetics & Genomes, 2020)

Mixed secondary chromatin structure revealed by modeling radiation-induced DNA fragment length distribution - Wenzong Ma; Chenyang Gu; Lin Ma; Caoqi Fan; Chao Zhang; Yujie Sun; Cheng Li; Gen Yang (Science China Life Sciences, 2020)

Isolation and characterization of a 295-bp strong promoter of maize high-affinity phosphate transporter gene ZmPht1; 5 in transgenic Nicotiana benthamiana and Zea mays - Wendi Li; Baiyu Liu; Mengsha Zhao; Ke Zhang; Qiuxia He; Xiangyu Zhao; Wen Cheng; Zhaohua Ding; Kewei Zhang; Kunpeng Li (Planta, 2020)

Mapping and characterization of major QTL for spike traits in common wheat - Cheng-Hao Kuang; Xiao-Fang Zhao; Ke Yang; Zhi-Peng Zhang; Li Ding; Zhi-En Pu; Jian Ma; Qian-Tao Jiang; Guo-Yue Chen; Ji-Rui Wang; Yu-Ming Wei; You-Liang Zheng; et al. (Physiology and Molecular Biology of Plants, 2020)

Morphological and Anatomical Differences among Three Seagrass Species in a High-energy Coastal Area Typically Dominated by Surfgrass in a Rocky Coastal Area of Shandong Peninsula, China - Wen-Tao Li; Jia Song; Chongfeng Zhong; Xin Hou; Ran Cheng; Pei-dong Zhang (Ocean Science Journal, 2020)

Improved production of GTKO/hCD55/hCD59 triple-gene-modified Diannan miniature pigs for xenotransplantation by recloning - Heng Zhao; Yuying Li; Thanapa Wiriyahdamrong; Zaimei Yuan; Yubo Qing; Honghui Li; Kaixiang Xu; Jianxiong Guo; Baoyu Jia; Xuezeng Zhang; Wenmin Cheng; Yanhua Su; et al. (Transgenic Research, 2020)

Impacts of Climate and Nutrients on Carbon Sequestration Rate by Wetlands: A Meta-analysis - Caifeng Cheng; Min Li; Zhenshan Xue; Zongsheng Zhang; Xianguo Lyu; Ming Jiang; Hongri Zhang (Chinese Geographical Science, 2020)

Baicalein attenuates caspase-independent cells death via inhibiting PARP-1 activation and AIF nuclear translocation in cerebral ischemia/reperfusion rats - Wei-Han Li; Ying-Lin Yang; Xiao Cheng; Man Liu; Shan-Shan Zhang; Yue-Hua Wang; Guan-Hua Du (Apoptosis, 2020)

Plastic pollution in croplands threatens long‐term food security - Dan Zhang; Ee Ling Ng; Wanli Hu; Hongyuan Wang; Pablo Galaviz; Hude Yang; Wentao Sun; Chongxiao Li; Xingwang Ma; Bin Fu; Peiyi Zhao; Fulin Zhang; et al. (Global Change Biology, 2020)
Plastic pollution is a global concern given its prevalence in aquatic and terrestrial ecosystems. Studies have been conducted on the distribution and impact of plastic pollution in marine ecosystems, but little is known on terrestrial ecosystems. Plastic mulch has been widely used to increase crop yields worldwide, yet the impact of plastic residues in cropland soils to soil health and crop production in the long term remained unclear. In this paper, using a global meta‐analysis, we found that the use of plastic mulch can indeed increase crop yields on average by 25%–42% in the immediate season due to the increase of soil temperature (+8%) and moisture (+17%). However, the unabated accumulation of film residues in the field negatively impacts its physicochemical properties linked to healthy soil and threatens food production in the long term. It has multiple negative impacts on plant growth including crop yield (at the mean rate of −3% for every additional 100 kg/ha of film residue), plant height (−2%) and root weight (−5%), and soil properties including soil water evaporation capacity (−2%), soil water infiltration rate (−8%), soil organic matter (−0.8%) and soil available phosphorus (−5%) based on meta‐regression. Using a nationwide field survey of China, the largest user of plastic mulch worldwide, we found that plastic residue accumulation in cropland soils has reached 550,800 tonnes, with an estimated 6%–10% reduction in cotton yield in some polluted sites based on current level of plastic residue content. Immediate actions should be taken to ensure the recovery of plastic film mulch and limit further increase in film residue loading to maintain the sustainability of these croplands.

Anti-phytopathogenic Bacterial Metabolites From the Seaweed-Derived Fungus Aspergillus sp. D40 - Rui-Huan Huang; Wei Lin; Peng Zhang; Jian-Yang Liu; Dan Wang; Yi-Qiang Li; Xiao-Qiang Wang; Cheng-Sheng Zhang; Wei Li; Dong-Lin Zhao (Frontiers in Marine Science, 2020)

Study on the Treatment of Nickel-Contaminated Soil Using Calcium Oxide - Zhen-li Xiang; Huan-fang Gao; Huan Yan; Ya-ling Li; Zhi-long Diao; En-zhi Zhang; Cong Li; Yuan-cheng Cao (Water, Air, & Soil Pollution, 2020)

Mature typhoon “cloud gyro” model and numerical simulation study - Xiaogang Huang; Xiangcheng Li; Xiaoping Cheng; Chenxi Zhang; Juli Ding (Science China Earth Sciences, 2020)

Correction to: Galangin inhibits hypertrophic scar formation via ALK5/Smad2/3 signaling pathway - Yifan Zhang; Shengzhou Shan; Jing Wang; Xinyu Cheng; Bo Yi; Jia Zhou; Qingfeng Li (Molecular and Cellular Biochemistry, 2020)

Dynamic Alterations of Brain Injury, Functional Recovery, and Metabolites Profile after Cerebral Ischemia/Reperfusion in Rats Contributes to Potential Biomarkers - Xiao Cheng; Ying-Lin Yang; Wei-Han Li; Man Liu; Shan-Shan Zhang; Yue-Hua Wang; Guan-Hua Du (Journal of Molecular Neuroscience, 2020)

The cognitive and neural mechanisms underlying norm-enforcement behaviors under social observation - Hui Ouyang; Fenfen Sun; Liping Che; Weidong Zhang; Xuemei Cheng; Li Zheng (Experimental Brain Research, 2020)

Transcriptome analysis revealed cadmium accumulation mechanisms in hyperaccumulator Siegesbeckia orientalis L. - Xiaoxun Xu; Shirong Zhang; Zhang Cheng; Ting Li; Yongxia Jia; Guiyin Wang; Zhanbiao Yang; Junren Xian; Yuanxiang Yang; Wei Zhou (Environmental Science and Pollution Research, 2020)

Laboratory investigation of the mechanical properties of coal-rock combined body - Zhan-bo Cheng; Liang-Hui Li; Ya-Ning Zhang (Bulletin of Engineering Geology and the Environment, 2020)

Antiviral activity of Illicium verum Hook. f. extracts against grouper iridovirus infection - Mingzhu Liu; Qing Yu; Hehe Xiao; Yi Yi; Hao Cheng; Dedi Fazriansyah Putra; Yaming Huang; Qin Zhang; Pengfei Li (Journal of Fish Diseases, 2020)
Grouper iridovirus causes high mortality rates in cultured groupers, and effective treatment for grouper iridovirus infection is urgently required. Illicium verum Hook. f. is a well‐known medicinal plant with a variety of biological activities. The aim of this study was to analyse the use of I. verum extracts to treat grouper iridovirus infection. The safe working concentration of each I. verum extract was identified both in vitro and in vivo as follows: I. verum aqueous extract (IVAE) ≤ 500 μg/ml; I. verum ethanol extract (IVEE) ≤ 250 μg/ml; shikimic acid (SKA) ≤ 250 μg/ml; trans‐anethole (TAT) ≤ 800 μg/ml; 3,4‐dihydroxybenzoic acid (DDBA) ≤ 400 μg/ml; and quercetin (QCE) ≤ 50 μg/ml. The inhibitory activity of each I. verum extract against grouper iridovirus infection was analysed using aptamer (Q2)‐based fluorescent molecular probe (Q2‐AFMP) and RT‐qPCR. All of the I. verum extracts displayed dose‐dependent antiviral activities against grouper iridovirus. Based on the achieved per cent inhibition, IVAE, IVEE, DDBA and QCE were associated with the greatest antiviral activity (all > 90%). Together, our results indicate that I. verum extracts have effective antiviral properties, making it an excellent potential source material for the development of effective treatment for grouper iridovirus infection.

Nanochemoprevention with therapeutic benefits: An updated review focused on epigallocatechin gallate delivery - Qiong-Qiong Yang; Xin-Lin Wei; Ya-Peng Fang; Ren-You Gan; Min Wang; Ying-Ying Ge; Dan Zhang; Li-Zeng Cheng; Harold Corke (Critical Reviews in Food Science and Nutrition, 2020)

AAV/BBB-Mediated Gene Transfer of CHIP Attenuates Brain Injury Following Experimental Intracerebral Hemorrhage - Shuo Zhang; Zheng-wei Hu; Hai-yang Luo; Cheng-yuan Mao; Mi-bo Tang; Yu-sheng Li; Bo Song; Yao-he Wang; Zhong-xian Zhang; Qi-meng Zhang; Li-yuan Fan; Yao Zhang; et al. (Translational Stroke Research, 2020)

Naturally Occurring Antibodies to Tau Exists in Human Blood and Are Not Changed in Alzheimer’s Disease - Zhong-Yuan Yu; Wei-Wei Li; Hai-Mei Yang; Noralyn B. Mañucat-Tan; Jun Wang; Ye-Ran Wang; Bin-Lu Sun; Zi-Cheng Hu; Li-Li Zhang; Liang Tan; Juan Deng; Yu-Hui Liu (Neurotoxicity Research, 2020)

Geological Control of Fold Structure on Gas Occurrence and Its Implication for Coalbed Gas Outburst: Case Study in the Qinan Coal Mine, Huaibei Coalfield, China - Kaizhong Zhang; Liang Wang; Yuanping Cheng; Wei Li; Jin Kan; Qingyi Tu; Jingyu Jiang (Natural Resources Research, 2020)

Phytochemicals and biological activities of species from the genus Maytenus - Lei Zhang; Ming-Yue Ji; Bin Qiu; Qin-Yu Li; Ke-Yong Zhang; Ji-Cheng Liu; Lian-Sheng Dang; Min-Hui Li (Medicinal Chemistry Research, 2020)

RIG-I aggravates interstitial fibrosis via c-Myc-mediated fibroblast activation in UUO mice - Zhuanli Zhou; Jiayun Ni; Jingyao Li; Chuanbing Huo; Naijun Miao; Fan Yin; Qian Cheng; Dan Xu; Hongyan Xie; Panpan Chen; Peiqing Zheng; Yingying Zhang; et al. (Journal of Molecular Medicine, 2020)
Progressive tubulointerstitial fibrosis is the common final outcome for all kidney diseases evolving into chronic kidney disease (CKD), whereas molecular mechanisms driving fibrogenesis remain elusive. Retinoic acid-inducible gene-I (RIG-I), an intracellular pattern recognition receptor, is originally identified participating in immune response by recognizing virus RNA. Here, we revealed for the first time that RIG-I was induced in unilateral ureteral obstruction (UUO) and folic acid (FA) renal fibrosis models and moderate-degree renal fibrosis patients. Besides, we found RIG-I was mainly located in renal tubular epithelial cells and promoted the production and release of inflammatory cytokines, such as interleukin (IL)-1β and IL-6 through activation of NF-κB. Inflammatory cytokines released by tubular epithelial cells activated c-Myc-mediated TGF-β/Smad signaling in fibroblasts, which in turn aggravated interstitial fibrosis by promoting fibroblast activation and production of extracellular matrix components (ECM). Deficiency of RIG-I attenuated renal fibrosis by the regulation of inflammatory responses, c-Myc expression, and fibroblast activation. Besides, gene silencing of RIG-I reduced inflammatory cytokines in cultured tubular epithelial cells treated with Angiotensin II. Knockdown of c-Myc or c-Myc inhibitor blocked IL-1β-induced fibroblast activation. Collectively, our study demonstrates that RIG-I plays a significant role in the progress of renal fibrosis via regulating c-Myc-mediated fibroblast activation. Key messages • RIG-I was constantly elevated in kidneys from renal fibrotic mice. • RIG-I facilitated inflammatory cytokine production in tubular epithelial cells. • RIG-I aggravated renal fibrosis via c-Myc-mediated TGF-β/Smad activation.

Dynamic change of vegetation and its response to climate and topographic factors in the Xijiang River basin, China - Lu Jia; Zhan-bin Li; Guo-ce Xu; Zong-ping Ren; Peng Li; Yu-ting Cheng; Yi-xin Zhang; Bin Wang; Jia-xin Zhang; Shu Yu (Environmental Science and Pollution Research, 2020)

Human umbilical cord mesenchymal stem cell exosomes alleviate sepsis-associated acute kidney injury via regulating microRNA-146b expression - Rongxue Zhang; Yuan Zhu; Yang Li; Wanzhu Liu; Lei Yin; Siqi Yin; Cheng Ji; Yuyan Hu; Qiongni Wang; Xinru Zhou; Jingyan Chen; Wenrong Xu; et al. (Biotechnology Letters, 2020)

Increased interregional functional connectivity of anterior insula is associated with improved smoking cessation outcome - Chao Wang; Zhujing Shen; Peiyu Huang; Wei Qian; Cheng Zhou; Kaicheng Li; Qingze Zeng; Xiao Luo; Quanquan Gu; Hualiang Yu; Yihong Yang; Minming Zhang (Brain Imaging and Behavior, 2020)

Genetic removal of the CH1 exon leads to the production of hypofunctional heavy chain-only IgG2a in rats - Zhenrong Li; Ming Zhang; Shunan Zheng; Yu Song; Xueqian Cheng; Di Yu; Lijuan Du; Liming Ren; Haitang Han; Yaofeng Zhao (Transgenic Research, 2020)

Dryland agricultural environment and sustainable productivity - Gou-Xia Li; Bing-Cheng Xu; Li-Na Yin; Shi-Wen Wang; Sui-Qi Zhang; Lun Shan; Sang-Soo Kwak; Qingbo Ke; Xi-Ping Deng (Plant Biotechnology Reports, 2020)

Hybrid constellation design using a genetic algorithm for a LEO-based navigation augmentation system - Fujian Ma; Xiaohong Zhang; Xingxing Li; Junlong Cheng; Fei Guo; Jiahuan Hu; Lin Pan (GPS Solutions, 2020)