The mediating role of coagulation function on the association of prenatal exposure to aflatoxin B1 and postpartum hemorrhage in Guangxi, China - Jiehua Chen; Ye Ye; Dongping Huang; Dongxiang Pan; Xiaoqiang Qiu; Lei Lei; Xingxi Luo; Jinxiu Li; Kaili Wu; Suyang Xiao; Shun Liu; Xiaoyun Zeng (Environmental Science and Pollution Research, 2022)

Microbial communities in swamps of four mangrove reserves driven by interactions between physicochemical properties and microbe in the North Beibu Gulf, China - Lu Li; Chunyan Peng; Zicong Yang; Yu He; Meng Liang; Hongmin Cao; Qinghua Qiu; Jingjing Song; Youlu Su; Bin Gong (Environmental Science and Pollution Research, 2022)

Functionalized porous nanoscale Fe3O4 particles supported biochar from peanut shell for Pb(II) ions removal from landscape wastewater - Xiaojun Jin; Renrong Liu; Huifang Wang; Li Han; Muqing Qiu; Baowei Hu (Environmental Science and Pollution Research, 2022)

Recent Developments in the Determination of PM2.5 Chemical Composition - Susu Pan; Yanting Qiu; Ming Li; Zhenqi Yang; Dapeng Liang (Bulletin of Environmental Contamination and Toxicology, 2022)

Tsp-1 is involved in DNA stability through Tgf-β1 activation domain in cone photoreceptor 661 W cells - Pei Chen; Chang Liu; Jing Zhang; Xi Chen; Xuan Liu; Shengyu He; Anqi He; Shuilian Chen; Jin Qiu; Yan Li; Zihua Jiang; Keming Yu; et al. (Cell and Tissue Research, 2022)

Phenotypic plasticity of light use favors a plant invader in nitrogen‐enriched ecosystems - Xiao Xu; Chenhao Zhou; Qiang He; Shiyun Qiu; Yan Zhang; Ji Yang; Bo Li; Ming Nie (Ecology, 2022)
Eutrophication is believed to promote plant invasion, resulting in high growth performances of invasive plants and, therefore, the great potential for growth‐induced intraspecific competition for light. Current hypotheses predict how eutrophication promotes plant invasion but fail to explain how great invasiveness is maintained under eutrophic conditions. In diverse native communities, co‐occurring plants of varying sizes can avoid light competition by exploiting light complementarily; however, whether this mechanism applies to intraspecific competition in invasive plant populations remains unknown. Using a 2‐year field nitrogen (N)‐enrichment experiment on one of the global invasive plants, Spartina alterniflora , we found that the plasticity of light use reduced intraspecific competition and increased biomass production in S. alterniflora . This plasticity effect was enhanced when S. alterniflora had no nutrient limitations. In the N‐enrichment treatments, the height difference among S. alterniflora ramets increased as light intensity decreased under the canopy. Compared with ambient N, under N enrichment, shorter individuals increased their light‐use efficiency and specific leaf area in response to the reduced light intensity under the canopy. However, such ecophysiological plasticity was not found for taller individuals. Our findings revealed that the light‐use plasticity of short individuals can be envisaged as a novel mechanism by which an invasive plant alleviates intraspecific competition and increases its invasiveness, challenging the prevailing perspective that the invasiveness of exotic plants is constrained by intraspecific competition.

Flavonoid glycosides from the nectar of Camellia reticulata Lindl. - Xin-Lan Chen; Xing-Rong Peng; Xue-Yang Gong; Yi-Qiu Liu; Zhuo Qing; Xiao-Xiao Ren; Rui Su; Li-Ming Fang; Ming-Hua Qiu; Kun Dong (Natural Product Research, 2022)

Simultaneous determination of praziquantel and its main metabolites in the tissues of black goats and their residue depletion - Tong-Yan Ding; Xiao-Gui Shu; Ren-Ping Xiong; Jing-Li Qiu; Lu Li; Li-Min He (Food Additives & Contaminants: Part A, 2022)

Dissection of the practical soybean breeding pipeline by developing ZDX1, a high-throughput functional array - Rujian Sun; Bincheng Sun; Yu Tian; Shanshan Su; Yong Zhang; Wanhai Zhang; Jingshun Wang; Ping Yu; Bingfu Guo; Huihui Li; Yanfei Li; Huawei Gao; et al. (Theoretical and Applied Genetics, 2022)
Key message We developed the ZDX1 high-throughput functional soybean array for high accuracy evaluation and selection of both parents and progeny, which can greatly accelerate soybean breeding. Abstract Microarray technology facilitates rapid, accurate, and economical genotyping. Here, using resequencing data from 2214 representative soybean accessions, we developed the high-throughput functional array ZDX1, containing 158,959 SNPs, covering 90.92% of soybean genes and sites related to important traits. By application of the array, a total of 817 accessions were genotyped, including three subpopulations of candidate parental lines, parental lines and their progeny from practical breeding. The fixed SNPs were identified in progeny, indicating artificial selection during the breeding process. By identifying functional sites of target traits, novel soybean cyst nematode-resistant progeny and maturity-related novel sources were identified by allele combinations, demonstrating that functional sites provide an efficient method for the rapid screening of desirable traits or gene sources. Notably, we found that the breeding index (BI) was a good indicator for progeny selection. Superior progeny were derived from the combination of distantly related parents, with at least one parent having a higher BI. Furthermore, new combinations based on good performance were proposed for further breeding after excluding redundant and closely related parents. Genomic best linear unbiased prediction (GBLUP) analysis was the best analysis method and achieved the highest accuracy in predicting four traits when comparing SNPs in genic regions rather than whole genomic or intergenic SNPs. The prediction accuracy was improved by 32.1% by using progeny to expand the training population. Collectively, a versatile assay demonstrated that the functional ZDX1 array provided efficient information for the design and optimization of a breeding pipeline for accelerated soybean breeding.

Enhanced genome editing to ameliorate a genetic metabolic liver disease through co-delivery of adeno-associated virus receptor - Shuming Yin; Lie Ma; Tingting Shao; Mei Zhang; Yuting Guan; Liren Wang; Yaqiang Hu; Xi Chen; Honghui Han; Nan Shen; Wenjuan Qiu; Hongquan Geng; et al. (Science China Life Sciences, 2022)

Anterior Cingulate Cortex Mediates Hyperalgesia and Anxiety Induced by Chronic Pancreatitis in Rats - Dan Ren; Jia-Ni Li; Xin-Tong Qiu; Fa-Ping Wan; Zhen-Yu Wu; Bo-Yuan Fan; Ming-Ming Zhang; Tao Chen; Hui Li; Yang Bai; Yun-Qing Li (Neuroscience Bulletin, 2022)
Central sensitization is essential in maintaining chronic pain induced by chronic pancreatitis (CP), but cortical modulation of painful CP remains elusive. Here, we examined the role of the anterior cingulate cortex (ACC) in the pathogenesis of abdominal hyperalgesia in a rat model of CP induced by intraductal administration of trinitrobenzene sulfonic acid (TNBS). TNBS treatment resulted in long-term abdominal hyperalgesia and anxiety in rats. Morphological data indicated that painful CP induced a significant increase in FOS-expressing neurons in the nucleus tractus solitarii (NTS) and ACC, and some FOS-expressing neurons in the NTS projected to the ACC. In addition, a larger portion of ascending fibers from the NTS innervated pyramidal neurons, the neural subpopulation primarily expressing FOS under the condition of painful CP, rather than GABAergic neurons within the ACC. CP rats showed increased expression of vesicular glutamate transporter 1, and increased membrane trafficking and phosphorylation of the N -methyl-D-aspartate receptor (NMDAR) subunit NR2B and the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) subunit GluR1 within the ACC. Microinjection of NMDAR and AMPAR antagonists into the ACC to block excitatory synaptic transmission significantly attenuated abdominal hyperalgesia in CP rats, which was similar to the analgesic effect of endomorphins injected into the ACC. Specifically inhibiting the excitability of ACC pyramidal cells via chemogenetics reduced both hyperalgesia and comorbid anxiety, whereas activating these neurons via optogenetics failed to aggravate hyperalgesia and anxiety in CP rats. Taken together, these findings provide neurocircuit, biochemical, and behavioral evidence for involvement of the ACC in hyperalgesia and anxiety in CP rats, as well as novel insights into the cortical modulation of painful CP, and highlights the ACC as a potential target for neuromodulatory interventions in the treatment of painful CP.

Exosome-derived miR-200a promotes esophageal cancer cell proliferation and migration via the mediating Keap1 expression - Peng Li; Xianben Liu; Wenqun Xing; Huiling Qiu; Renling Li; Shilei Liu; Haibo Sun (Molecular and Cellular Biochemistry, 2022)

Exploring the Potential Antidepressant Mechanisms of Pinellia by Using the Network Pharmacology and Molecular Docking - Yu-Gang Xiao; Han-Biao Wu; Ji-Sheng Chen; Xiong Li; Zhi-Kun Qiu (Metabolic Brain Disease, 2022)

Structure identification of a karst groundwater system based on high-resolution rainfall-hydrological response characteristics - Zongxing Wang; Rui Wu; Kun Huang; Yang Qiu; Zhongxia Li; You Lv; Junwei Wan (Environmental Science and Pollution Research, 2022)

IgE Reactivity of Potential Allergens from the Swimming Crab Portunus trituberculatus and the Research of ELISA Reagent for Detecting Crab Food Anaphylaxis - Xueni Qiu; Qiongyan Zhou; Xiaoxia Zhu; Wei Lin; Changkao Mu; Ronghua Li; Yangfang Ye; Weiwei Song; Ce Shi; Lei Liu; Huan Wang; Chunlin Wang; et al. (Journal of Ocean University of China, 2022)

Immersion mode and spatiotemporal distribution characteristic of water migration in loess tunnel - Wangshuaiyin Shi; Junling Qiu; Chengping Zhang; Qiang Wang; Jinxing Lai; Binglong Li; Zhengjun Mao (Arabian Journal of Geosciences, 2022)

Expansion of bilin‐based red light sensors in the subaerial desert cyanobacterium Nostoc flagelliforme - Hai‐Feng Xu; Guo‐Zheng Dai; Yu‐Jie Wang; Chao Cheng; Jin‐Long Shang; Ren‐Han Li; Ke Liu; Deqiang Duanmu; Bao‐Sheng Qiu (Environmental Microbiology, 2022)
Summary Light is the crucial environmental signal for desiccation‐tolerant cyanobacteria to activate photosynthesis and prepare for desiccation at dawn. However, the photobiological characteristics of desert cyanobacteria adaptation to one of the harshest habitats on Earth remain unresolved. In this study, we surveyed the genome of a subaerial desert cyanobacterium Nostoc flagelliforme and identified two phytochromes and seven cyanobacteriochromes (CBCRs) with one or more bilin‐binding GAF (cGMP phosphodiesterase/adenylyl cyclase/FhlA) domains. Biochemical and spectroscopic analyses of 69 purified GAF‐containing proteins from recombinant phycocyanobilin (PCB), biliverdin or phycoerythrobilin‐producing Escherichia coli indicated that nine of these proteins bind chromophores. Further investigation revealed that 11 GAFs form covalent adducts responsive to near‐UV and visible light: eight GAFs contained PCB chromophores, three GAFs contained biliverdin chromophores and one contained the PCB isomer, phycoviolobilin. Interestingly, COO91_03972 is the first‐ever reported GAF‐only CBCR capable of sensing five wavelengths of light. Bioinformatics and biochemical analyses revealed that residue P132 of COO91_03972 is essential for chromophore binding to dual‐cysteine CBCRs. Furthermore, the complement of N . flagelliforme CBCRs is enriched in red light sensors. We hypothesize that these sensors are critical for the acclimatization of N . flagelliforme to weak light environments at dawn.

Uplift and exhumation in the Tianshan, western China: New insights from detrital zircon morphology and thermochronology - Jian Chang; Yinglin Zhang; Nansheng Qiu; Chenxing Li (Science China Earth Sciences, 2022)

The CBM48 domain-containing protein FLO6 regulates starch synthesis by interacting with SSIVb and GBSS in rice - Long Zhang; Ning Li; Jing Zhang; Linglong Zhao; Jiajing Qiu; Cunxu Wei (Plant Molecular Biology, 2022)

Red Fluorescence of Eu3+-Doped ZnAl-LDH Response to Intercalation and Release of Ibuprofen - Yufeng Chen; Xingxing Qiu; Chao Li; Yajiao Zhang; Yongxiu Li (Journal of Fluorescence, 2022)

CAV1 is a prognostic predictor for patients with idiopathic pulmonary fibrosis and lung cancer - Dongdong Yin; Jiayang Qiu; Suxia Hu; Longqiang Cheng; Hui Li; Xingpu Cheng; Shun Wang; Jun Lu (Journal of Biosciences, 2022)

Discovery of a Natural Product with Potent Efficacy Against SARS-CoV-2 by Drug Screening - Daixi Li; Cheng Wang; Shaobo Wang; Aamir Mehmood; Jiang Gu; Xin Cheng; Peiqin Chen; JingFei Qiu; Jinghong Zhao; Junping Wang; Dongqing Wei (Interdisciplinary Sciences: Computational Life Sciences, 2022)

Deciphering the influence of urinary microbiota on FoxP3+ regulatory T cell infiltration and prognosis in Chinese patients with non-muscle-invasive bladder cancer - Yifeng Qiu; Yubo Gao; Chunxiao Chen; Ming Xie; Pengcheng Huang; Qi Sun; Zhipeng Zhou; Biao Li; Jie Zhao; Peng Wu (Human Cell, 2022)

Dissecting four correlated growth period traits using a genome-wide association study approach in soybean - Yanfei Li; Ying-hui Li; Huilong Hong; Yansong Ma; Yongzhe Gu; Zhangxiong Liu; Scott A. Jackson; Li-juan Qiu (Genetic Resources and Crop Evolution, 2022)

QTL mapping integrated with BSA-Seq analysis identifies a novel gene conferring resistance to brown planthopper from common wild rice (Oryza rufipogon Griff.) - Xuan Wang; Yue Han; Yue-xiong Zhang; Biao Deng; Bi-qiu Wu; Xin-ying Guo; Yu-fen Qin; Yao-yu Fang; Fang Liu; Bao-xiang Qin; Ji-jing Luo; Rong-bai Li (Euphytica, 2022)

Simulation of potential suitable distribution of original species of Fritillariae Cirrhosae Bulbus in China under climate change scenarios - Lei Liu; Yuanyuan Zhang; Yi Huang; Jindong Zhang; Qiuyu Mou; Jianyue Qiu; Rulin Wang; Yujie Li; Dequan Zhang (Environmental Science and Pollution Research, 2022)

Text visualization for geological hazard documents via text mining and natural language processing - Ying Ma; Zhong Xie; Gang Li; Kai Ma; Zhen Huang; Qinjun Qiu; Hui Liu (Earth Science Informatics, 2022)

Extraction of temporal information from social media messages using the BERT model - Kai Ma; Yongjian Tan; Miao Tian; Xuejing Xie; Qinjun Qiu; Sanfeng Li; Xin Wang (Earth Science Informatics, 2022)

Synergistic Effects of Aquatic Plants and Cyanobacterial Blooms on the Nitrous Oxide Emission from Wetlands - Huazu Liu; Qiu Jin; Junxiao Luo; Yan He; Shenhua Qian; Wei Li (Bulletin of Environmental Contamination and Toxicology, 2022)

Gas hazard evaluation for tunnel construction in coal-bearing Longtan Formation, South China - Peidong Su; Kunchen He; Tao Feng; Peng Qiu; Zhengxuan Xu; Yougui Li (Bulletin of Engineering Geology and the Environment, 2022)

The damage mechanism and deterioration characteristics of acid-corroded sandstone: an experimental study - Runke Huo; Yanling Liang; Shuguang Li; Zizhen Miao; Tian Qiu (Arabian Journal of Geosciences, 2022)

Intelligent prediction of coal mine water inrush based on optimized SAPSO-ELM model under the influence of multiple factors - Yong-gang Zhang; Yuan-lun Xie; Li-ning Yang; Rao-ping Liao; Tao Qiu (Arabian Journal of Geosciences, 2022)
Mine water inrush is affected by many factors such as geological structure and fracture zone. However, there may be overlap among these factors, leading to uncertainty, fuzzy similarity and nonlinear relationship among most of them. Therefore, the traditional mathematical model is not ideal to predict water inrush. This paper proposes an intelligent model for predicting water inrush from coal floor based on simulated annealing particle swarm optimization-extreme learning machine (SAPSO-ELM). Based on 144 groups of learning data and 36 groups of predictive validation data, the proposed model extracted common factors from 14 geological factors that might be related to water inrush in a mining area, so as to reduce information interaction among discriminant indexes. In this paper, simulated annealing particle swarm optimization (SAPSO) is innovatively used to optimize the model parameters and compared with other intelligent models (SVM, BPNN, PSO-ELM and ELM) for the learning prediction of the same data. The results show that the common factors extracted from the original variables contain most of the comprehensive information and can reduce information redundancy. Compared with traditional intelligent models (SVM, BPNN, PSO-ELM and ELM), the proposed model improves the computational efficiency of convergence, and the prediction accuracy is higher. It is proved that SAPSO-ELM intelligent algorithm is indeed scientific and has broad application prospect in result prediction induced by complex multi-factors.

Seismic high-resolution processing method based on spectral simulation and total variation regularization constraints - Guo Xin; Gao Jian-Hu; Yin Xun-De; Yong Xue-Shan; Wang Hong-Qiu; Li Sheng-Jun (Applied Geophysics, 2022)

Morphological and Molecular Characterization of Paragonimus skrjabini Complex from Yunnan, China: A Brief Report - Qiu-Hong Shu; Shu-De Li; Ming Tian; Yong Meng; Shu-Mei-Qi He; Min Zhu; Miao-Miao Wang; Wen-Lin Wang (Acta Parasitologica, 2022)
Purpose To perform environmental sampling and molecular identification of Paragonimus in endemic regions, which may help in minimizing transmission among humans. Methods Mountain crabs from the genus Potamiscus were collected and the encysted metacercariae were extracted and subjected to morphological identification, followed by animal inoculation in Sprague–Dawley (SD) rats. After 112 days of infection, animals were killed and adult worms were extracted from lungs and muscles. The morphology of adult worms was characterized by microscopy and molecular identification was done by polymerase chain reaction, followed by sequencing of cox1 and ITS2 genes. Phylogenetic analysis was done by maximum parsimony method. Results A total of 447 crabs were captured from the streams of Tongchang Town, Jinping County, Yunnan Province, China. The infection rate was found to be 41% (186 out of 447 crabs). The metacercariae of Paragonimus skrjabini was identified by the characteristics round or spherical encysted form measuring 410 to 460 × 400 to 460 µm. After animal infection in SD rats, adults were presumptively confirmed to be P. skrjabini , which was also confirmed by gene amplification and sequence analysis of cox1 and ITS2 regions. Paragonimus skrjabini clustered with previously reported P. skrjabini from Yunnan and Vietnam. The confidence values of their branches were > 95%. Phylogenetic analysis of the ITS2 region revealed two distinct clusters with distinct geographical grouping. Phylogenetic analysis with the combined data sets reiterated the geographical grouping with P. skrjabini from Yunnan clustering with strains from Vietnam. Conclusion Metacercariae of P. skrjabini was discovered in freshwater crabs in Yunnan province, China, and the strains were phylogenetically related to P. skrjabini from Vietnam.

Identification, Characterization, and Expression of a PRQFVamide-Related Peptide in Cephalopod Sepiella japonica - Jia-yin Qiu; Li-bing Zheng; Chang-feng Chi (Frontiers in Marine Science, 2022)
Neuropeptides, as neurotransmitters and neuromodulators, have a variety of physiological functions in the mollusk. Here, a PRQFVamide-related peptide gene was cloned from cuttlefish Sepiella japonica (designated as SjPRQFVRP , GenBank Accession No: OK999997 ). The full length of SjPRQFVRP is 1748 bp, including an open reading frame (ORF) of 738 bp encoding 245 amino acids. The putative precursor protein comprises one signal peptide and four different mature pentapeptides: fourteen copies of PMEFLamide, three copies of RMEFLamide, one copy of AMEFLamide and GMEFLamide. Multiple alignments showed Sj PRQFVRP shared 71% identity with that of Octopus vulgaris and supported the phylogenetic analysis. The spatio-temporal expression pattern showed that SjPRQFVRP mRNA was widely expressed among the 13 tissues and primarily abundantly expressed in the brain and optic lobe during the whole development stage. In situ hybridization data indicated that SjPRQFVRP was detected in the vertical lobe, subvertical lobe, anterior basal lobe, anterior pedal lobe, and optic lobes of the brain. Subcellular localization analysis revealed that the Sj PRQFVRP protein was localized in the cytoplasm of HEK293 cells. Collectively, the results will provide a foundation for further exploring the mechanism of SjPRQFVRP function in cephalopods.

Susceptibility of patients with chronic obstructive pulmonary disease to heart rate difference associated with the short-term exposure to metals in ambient fine particles: A panel study in Beijing, China - Ke Gao; Xi Chen; Xiaoying Li; Hanxiyue Zhang; Mengxiao Luan; Yuan Yao; Yifan Xu; Teng Wang; Yiqun Han; Tao Xue; Junxia Wang; Mei Zheng; et al. (Science China Life Sciences, 2022)

Shifting from homogeneous to heterogeneous surfaces in estimating terrestrial evapotranspiration: Review and perspectives - Yuanbo Liu; Guoyu Qiu; Hongsheng Zhang; Yonghui Yang; Yinsheng Zhang; Quan Wang; Wenzhi Zhao; Li Jia; Xibin Ji; Yujiu Xiong; Chunhua Yan; Ning Ma; et al. (Science China Earth Sciences, 2022)

Genome-wide identification of HD-ZIP transcription factors in maize and their regulatory roles in promoting drought tolerance - Xiao Qiu; GuoRui Wang; Salah Fatouh Abou-Elwafa; Jiaxu Fu; Zhixue Liu; PengYu Zhang; Xiaowen Xie; Lixia Ku; Ying Ma; XiaoKang Guan; Li Wei (Physiology and Molecular Biology of Plants, 2022)

Glomalin-related soil protein (GRSP) in metal sequestration at Pb/Zn-contaminated sites - Lang Qiu; Hanzhi Lin; Benru Song; Tianle Kong; Weimin Sun; Xiaoxu Sun; Yanxu Zhang; Baoqin Li (Journal of Soils and Sediments, 2022)

Mass cultivation of conidia of Pyricularia oryzae - Zhong-na Hao; Hai-ping Qiu; Zhen Zhang; Rong-yao Chai; Shi-zhen Wang; Yan-li Wang; Jiao-yu Wang; Guo-chang Sun (Journal of Plant Pathology, 2022)

High-resolution dynamical downscaling for regional climate projection in Central Asia based on bias-corrected multiple GCMs - Yuan Qiu; Jinming Feng; Zhongwei Yan; Jun Wang; Zhen Li (Climate Dynamics, 2022)

The brain functional connectivity in the default mode network is associated with self-efficacy in young adults - Xi Wang; Qunlin Chen; Yu Li; Ke Ding; Jiang Qiu (Brain Imaging and Behavior, 2022)

Basal ganglia-orbitofrontal circuits are associated with prospective memory deficits in Wilson’s disease - Sheng Hu; ChunSheng Xu; Yi Wang; Ting Dong; Hongli Wu; Anqin Wang; Chuanfu Li; BenSheng Qiu (Brain Imaging and Behavior, 2022)

Characterization of a novel Vibrio parahaemolyticus host-phage pair and antibacterial effect against the host - Chao Gao; Xiaobo Yang; Chen Zhao; Chenyu Li; Shang Wang; Xi Zhang; Bin Xue; Zhuosong Cao; Hongrui Zhou; Yutong Yang; Zhiqiang Shen; Pingfeng Yu; et al. (Archives of Virology, 2022)

Oxidation of organoarsenicals and antimonite by a novel flavin monooxygenase widely present in soil bacteria - Jun Zhang; Jian Chen; Yi‐Fei Wu; Zi‐Ping Wang; Ji‐Guo Qiu; Xiao‐Long Li; Feng Cai; Ke‐Qing Xiao; Xiao‐Xu Sun; Barry P. Rosen; Fang‐Jie Zhao (Environmental Microbiology, 2022)
Summary Arsenic can be biomethylated to form a variety of organic arsenicals differing in toxicity and environmental mobility. Trivalent methylarsenite (MAs(III)) produced in the methylation process is more toxic than inorganic arsenite (As(III)). MAs(III) also serves as a primitive antibiotic and, consequently, some environmental microorganisms have evolved mechanisms to detoxify MAs(III). However, the mechanisms of MAs(III) detoxification are not well understood. In this study, we identified an arsenic resistance ( ars ) operon consisting of three genes, arsRVK , that contribute to MAs(III) resistance in Ensifer adhaerens ST2. ArsV is annotated as an NADPH‐dependent flavin monooxygenase with unknown function. Expression of arsV in the arsenic hypersensitive Escherichia coli strain AW3110 Δars conferred resistance to MAs(III) and the ability to oxidize MAs(III) to MAs(V). In the presence of NADPH and either FAD or FMN, purified ArsV protein was able to oxidize both MAs(III) to MAs(V) and Sb(III) to Sb(V). Genes with arsV ‐like sequences are widely present in soils and environmental bacteria. Metagenomic analysis of five paddy soils showed the abundance of arsV ‐like sequences of 0.12–0.25 ppm. These results demonstrate that ArsV is a novel enzyme for the detoxification of MAs(III) and Sb(III) and the genes encoding ArsV are widely present in soil bacteria.

Indicator species drive the key ecological functions of microbiota in a river impacted by acid mine drainage generated by rare earth elements mining in South China - Ziwu Chen; Xi Zhong; Mengyuan Zheng; Wen‐Shen Liu; Yingheng Fei; Kengbo Ding; Yaying Li; Ye Liu; Yuanqing Chao; Ye‐Tao Tang; Shizhong Wang; Rongliang Qiu (Environmental Microbiology, 2022)
Summary Acid mine drainage (AMD) generated by rare earth elements (REEs) deposits exploration contains high concentrations of REEs, ammonium and sulfates, which is quite different from typical metallic AMD. Currently, microbial responses and ecological functions in REEs‐AMD impacted rivers are unknown. Here, 16S rRNA analysis and genome‐resolved metagenomics were performed on microbial community collected from a REEs‐AMD contaminated river. The results showed that REEs‐AMD significantly changed river microbial diversity and shaped unique indicator species (e.g. Thaumarchaeota , Methylophilales , Rhodospirillales and Burkholderiales ). The main environmental factors regulating community were pH, ammonium and REEs, among which high concentration of REEs increased REEs‐dependent enzyme‐encoding genes ( XoxF and ExaF / PedH ). Additionally, we reconstructed 566 metagenome‐assembled genomes covering 70.4% of identifying indicators. Genome‐centric analysis revealed that the abundant archaea Thaumarchaeota and Xanthomonadaceae were often involved in nitrification and denitrification, while family Burkholderiaceae were capable of sulfide oxidation coupled with dissimilatory nitrate reduction to ammonium. These indicators play crucial roles in nitrogen and sulfur cycling as well as REEs immobilization in REEs‐AMD contaminated rivers. This study confirmed the potential dual effect of REEs on microbial community at the functional gene level. Our investigation on the ecological roles of indicators further provided new insights for the development of REEs‐AMD bioremediation.

Identification and characterization of magnetotactic Gammaproteobacteria from a salt evaporation pool, Bohai Bay, China - Peiyu Liu; Alima Tamaxia; Yan Liu; Hao Qiu; Juntong Pan; Zhongke Jin; Xiang Zhao; Andrew P. Roberts; Yongxin Pan; Jinhua Li (Environmental Microbiology, 2022)
Summary Magnetotactic bacteria (MTB) are phylogenetically diverse prokaryotes that can produce intracellular chain‐assembled nanocrystals of magnetite (Fe 3 O 4 ) or greigite (Fe 3 S 4 ). Compared with their wide distribution in the Alpha‐, Eta‐ and Delta‐proteobacteria classes, few MTB strains have been identified in the Gammaproteobacteria class, resulting in limited knowledge of bacterial diversity and magnetosome biomineralization within this phylogenetic branch. Here, we identify two magnetotactic Gammaproteobacteria strains (tentatively named FZSR‐1 and FZSR‐2 respectively) from a salt evaporation pool in Bohai Bay, at the Fuzhou saltern, Dalian City, eastern China. Phylogenetic analysis indicates that strain FZSR‐2 is the same species as strains SHHR‐1 and SS‐5, which were discovered previously from brackish and hypersaline environments respectively. Strain FZSR‐1 represents a novel species. Compared with strains FZSR‐2, SHHR‐1 and SS‐5 in which magnetite particles are assembled into a single chain, FZSR‐1 cells form relatively narrower magnetite nanoparticles that are often organized into double chains. We find a good relationship between magnetite morphology within strains FZSR‐2, SHHR‐1 and SS‐5 and the salinity of the environment in which they live. This study expands the bacterial diversity of magnetotactic Gammaproteobacteria and provides new insights into magnetosome biomineralization within magnetotactic Gammaproteobacteria.

Responses of Rhodotorula mucilaginosa under Pb( II ) stress: carotenoid production and budding - Zhijun Wang; Ying Zhang; Liu Jiang; Jingjing Qiu; Yanan Gao; Tingting Gu; Zhen Li (Environmental Microbiology, 2022)
Summary Rhodotorula mucilaginosa resists heavy metal (HM) stress because of its abundant extracellular polymeric substances and functional vesicles. In this study, we provided new insights into its survival strategies at both biochemical and genetic levels. After lead exposure, carotenoid biosynthesis was initiated within 24 h incubation and then increased to the maximum after 96 h of incubation. Raman analysis confirmed that carotenoids (primarily β‐carotene) were the major identifiable chemical substances on the cell surface. Moreover, the increased carotenoid production was accompanied by a rising budding rate, ~40% higher than that in the cultures without Pb. During the 96 h of incubation, the driving force for Pb accumulation was assigned to this elevated budding rate. After 96 h, biosorption was primarily attributed to the enhanced antioxidant ability of the single cells during carotenoid production. Furthermore, the yeast budding cells demonstrated an evidently heterogeneous biosorption of Pb, i.e., the rejuvenated daughters had a relatively lower Pb level than the mother cells. This resulted in the protection of the buds from Pb stress. After investigating phosphorus uptake and the RNA sequencing data, we finally confirmed two tightly correlated pathways that resist HM stress, i.e., biochemical (carotenoid production) and reproductive (healthy buds) pathways.

Genetic dissection of quantitative trait loci for grain size and weight by high-resolution genetic mapping in bread wheat (Triticum aestivum L.) - Tao Li; Guangbing Deng; Yan Su; Zhao Yang; Yanyan Tang; Jinhui Wang; Juanyu Zhang; Xvebing Qiu; Xi Pu; Wuyun Yang; Jun Li; Zehou Liu; et al. (Theoretical and Applied Genetics, 2022)

Rice functional genomics: decades’ efforts and roads ahead - Rongzhi Chen; Yiwen Deng; Yanglin Ding; Jingxin Guo; Jie Qiu; Bing Wang; Changsheng Wang; Yongyao Xie; Zhihua Zhang; Jiaxin Chen; Letian Chen; Chengcai Chu; et al. (Science China Life Sciences, 2022)

Estrogen-induced downregulation of TASK-1 expression through estrogen receptor β in N2A cells - Xiao-Yue Qiu; Xian-Tao Li (Molecular Biology Reports, 2022)

The frequency of cannibalism by Spodoptera frugiperda larvae determines their probability of surviving food deprivation - Hualiang He; Ailin Zhou; Li He; Lin Qiu; Wenbing Ding; Youzhi Li (Journal of Pest Science, 2022)

Association of hearing loss with total and cause-specific mortality in US adults - Xiaobing Feng; Wenzhen Li; Man Cheng; Weihong Qiu; Ruyi Liang; Minjing Li; Weihong Chen; Dongming Wang (Environmental Science and Pollution Research, 2022)

Adenine base-editing-mediated exon skipping induces gene knockout in cultured pig cells - Xiang-xing Zhu; Jia-sheng Pan; Tao Lin; Ye-cheng Yang; Qiu-yan Huang; Shuai-peng Yang; Zi-xiao Qu; Zi-sheng Lin; Jian-cong Wen; Ai-fen Yan; Juan Feng; Lian Liu; et al. (Biotechnology Letters, 2022)

Using computational fluid dynamic simulation with Flow-3D to reveal the origin of the mushroom stone in the Xiqiao Mountain of Guangdong, China - Jian-cheng Li; Wei Wang; Yan-ming Zheng; Xiao-hao Wen; Jing Feng; Li Sheng; Chen Wang; Ming-kun Qiu (Journal of Mountain Science, 2022)

Human bocavirus 2 detected in Rattus norvegicus feces in China - Fang-Fei You; Min-Yi Zhang; Fei Wu; Qiu-Shuang Li; Qing Chen (Archives of Virology, 2022)

Ground fissure disasters and mitigation measures for hazards during metro system construction in Xi’an, China - Ziqi Li; Jinxing Lai; Yao Li; Junling Qiu; Yufeng Shi; Binglong Li; Feifei Fan (Arabian Journal of Geosciences, 2022)

Responses of soil pH to no‐till and the factors affecting it: A global meta‐analysis - Xin Zhao; Cong He; Wen‐Sheng Liu; Wen‐Xuan Liu; Qiu‐Yue Liu; Wei Bai; Li‐Jun Li; Rattan Lal; Hai‐Lin Zhang (Global Change Biology, 2022)
No‐till (NT) is a sustainable option because of its benefits in controlling erosion, saving labor, and mitigating climate change. However, a comprehensive assessment of soil pH response to NT is still lacking. Thus, a global meta‐analysis was conducted to determine the effects of NT on soil pH and to identify the influential factors and possible consequences based on the analysis of 114 publications. When comparing tillage practices, the results indicated an overall significant decrease by 1.33 ± 0.28% in soil pH under NT than that under conventional tillage ( p −1 (−1.83%), or crop residue retention (−1.52%). Changes in organic matter decomposition under undisturbed soil and with crop residue retention might lead to a higher concentration of H + and lower of basic cations (i.e., calcium, magnesium, and potassium), which decrease the soil pH, and consequently, impact nutrient dynamics (i.e., soil phosphorus) in the surface layer under NT. Furthermore, soil acidification may be aggravated by NT within site‐specific conditions and improper fertilizer and crop residue management and consequently leading to adverse effects on soil nutrient availability. Thus, there is a need to identify strategies to ameliorate soil acidification under NT to minimize the adverse consequences.

Two new bioactive polyphenols from the soft coral-derived fungus Talaromyces sp. SCSIO 041201 - Ji-xing Li; Xin-xin Lei; Yan-hong Tan; Yong-hong Liu; Bin Yang; Yun-qiu Li (Natural Product Research, 2021)

Bioactive compounds derived from the marine-derived fungus MCCC3A00951 and their influenza neuraminidase inhibition activity in vitro and in silico - Shun-Zhi Liu; Feng-Ming He; Yan-lin Bin; Chu-Fang Li; Bao-Ying Xie; Xi-Xiang Tang; Ying-Kun Qiu (Natural Product Research, 2021)

Maternal intake of caffeinated products and birth defects: a systematic review and meta-analysis of observational studies - Yan Yue; Wenxing Li; Jun Tang; Yan Zeng; Tao Xiong; Xia Qiu; Jing Shi; Hua Wang; Bin Xia; Lili Luo; Yi Qu; Dezhi Mu (Critical Reviews in Food Science and Nutrition, 2021)

Contrasting latest Permian intracontinental gabbro and Late Triassic arc gabbro–diorite in the Gangdese constrain the subduction initiation of the Neo-Tethys - Qiu-Huan Li; Kai-Jun Zhang; Li-Long Yan; Xin Jin (International Geology Review, 2021)

Goodyschle A, a new butenolide with significant BchE inhibitory activity from Goodyera schlechtendaliana - Le-Yao Dai; Qi-Meng Yin; Jia-Kai Qiu; Zhen-Yang Zhang; Gang Li; Meng-Ni Huang; Liang Liu (Natural Product Research, 2021)

Occurrence State of Soluble Organic Matter in Shale Oil Reservoirs from the Upper Triassic Yanchang Formation in the Ordos Basin, China: Insights from Multipolarity Sequential Extraction - Shutong Li; Shixiang Li; Ruiliang Guo; Xinping Zhou; Yang Wang; Junlin Chen; Jiaqiang Zhang; Lewei Hao; Xiaofeng Ma; Junli Qiu (Natural Resources Research, 2021)

Molecular cloning and characterization of NPC1L1 in the Chinese tree shrew (Tupaia belangeri chinensis) - Xiuying Kui; Dandan Qiu; Wenguang Wang; Na Li; Pinfen Tong; Xiaomei Sun; Liangzi Jin; Wei Deng; Jiejie Dai; Caixia Lu (Molecular Biology Reports, 2021)

Correction to: HD5 and LL‑37 Inhibit SARS‑CoV and SARS‑CoV‑2 Binding to Human ACE2 by Molecular Simulation - Daixi Li; Peiqin Chen; Ting Shi; Aamir Mehmood; Jingfei Qiu (Interdisciplinary Sciences: Computational Life Sciences, 2021)

HD5 and LL-37 Inhibit SARS-CoV and SARS-CoV-2 Binding to Human ACE2 by Molecular Simulation - Daixi Li; Peiqin Chen; Ting Shi; Aamir Mehmood; Jingfei Qiu (Interdisciplinary Sciences: Computational Life Sciences, 2021)

Bacterial Community Structure and Diversity in the Aqueous Environment of Shihou Lake and its Relationship with Environmental Factors - Ru Deng; Xi Chen; Li-Ping Qiu; Jia-Zhang Chen; Shun-Long Meng (Indian Journal of Microbiology, 2021)

Lethal and sublethal effects of emamectin benzoate on life-table and physiological parameters of citrus red mite, Panonychus citri - Muhammad Musa Khan; Muhammad Waqar Ali; Muhammad Hafeez; Ze-Yun Fan; Shaukat Ali; Bao-Li Qiu (Experimental and Applied Acarology, 2021)

Correction to: Enhanced adsorption of phosphorus in soil by lanthanum-modified biochar: improving phosphorus retention and storage capacity - Di Zhao; Yuan Luo; Yi-yang Feng; Qiu-ping He; Li-sheng Zhang; Ke-qiang Zhang; Feng Wang (Environmental Science and Pollution Research, 2021)

Catalytic activity, selectivity, and stability of co-precipitation synthesized Mn-Ce mixed oxides for the oxidation of 1,2-dichlorobenzene - Juan Qiu; Yaqi Peng; Minghui Tang; Shengyong Lu; Xiaodong Li; Jianhua Yan (Environmental Science and Pollution Research, 2021)

Enhanced adsorption of phosphorus in soil by lanthanum-modified biochar: improving phosphorus retention and storage capacity - Di Zhao; Yuan Luo; Yi-yang Feng; Qiu-ping He; Li-sheng Zhang; Ke-qiang Zhang; Feng Wang (Environmental Science and Pollution Research, 2021)

Citric acid and AMF inoculation combination–assisted phytoextraction of vanadium (V) by Medicago sativa in V mining contaminated soil - Lang Qiu; Wenlong Gao; Zhigang Wang; Baoqin Li; Weimin Sun; Pin Gao; Xiaoxu Sun; Benru Song; Yanxu Zhang; Tianle Kong; Hanzhi Lin (Environmental Science and Pollution Research, 2021)

Association of systemic inflammation indices with visual field loss progression in patients with primary angle-closure glaucoma: potential biomarkers for 3P medical approaches - Shengjie Li; Yichao Qiu; Jian Yu; Mingxi Shao; Yingzhu Li; Wenjun Cao; Xinghuai Sun (EPMA Journal, 2021)

Dinoflagellate-targeted PCR reveals highly abundant and diverse communities of parasitic dinoflagellates in and near Zhubi Reef, South China Sea - Dajun Qiu; Liangmin Huang; Yunyun Zhuang; Yu Zhong; Yuehui Tan; Xiubao Li; Sheng Liu; Hui Huang; Senjie Lin (Coral Reefs, 2021)

Methods for detection of Helicobacter pylori from stool sample: current options and developments - Enming Qiu; Zhou Li; Shuai Han (Brazilian Journal of Microbiology, 2021)
Accurate detection of Helicobacter pylori infection and determination of antibiotics have significant meaning in clinical practice. The detection methods can be categorized into two types, invasive and non-invasive, but nowadays we use the urease breath test most frequently which is non-invasive. However, many developing countries cannot meet the requirements for having specialized equipment and they lack trained personnel. Also, for the children, it is difficult to make them cooperate for the test. Methods that detect Helicobacter pylori from stool sample can be a promising alternative for detection used in children and mass screening. Stool antigen tests have several advantages such as rapidity, simplicity, and cheapness, though their results may be influenced by the heterogenicity of antigens, the nature of biochemical techniques, and the amount of antigen presented in the stool. PCR-based methods can specifically detect Helicobacter pylori infection and antibiotic resistance by targeting specific gene sequence, but they also are limited by the requirements of facilities and experts, the existence of inhibitory substance, and interference from the dead bacteria. Some novel methods also deserve our attention. Here we summarized the results of researches about methods using stool sample and we hope our work can help clinicians choose the appropriate test in clinical practice.

lp norm inverse spectral decomposition and its multi-sparsity fusion interpretation - Li Sheng-Jun; Wang Tie-Yi; Gao Jian-Hu; Liu Bing-Yang; Gui Jin-Yong; Wang Hong-Qiu (Applied Geophysics, 2021)

Correction to: AGGF1 protects from myocardial ischemia/reperfusion injury by regulating myocardial apoptosis and angiogenesis - Yu Liu; Hui Yang; Lina Song; Nan Li; Qiu-Yue Han; Cui Tian; Erhe Gao; Jie Du; Yun-Long Xia; Hui-Hua Li (Apoptosis, 2021)

Photobleaching and Recovery of Symbiodiniaceae Effrenium voratum SCS01 Reveals Life Form Transformation Under Thermal Stress - Sanqiang Gong; Gang Li; Xuejie Jin; Dajun Qiu; Jiayuan Liang; Kefu Yu; Yehui Tan; Xiao Ma; Xiaomin Xia (Frontiers in Marine Science, 2021)
Dinoflagellates in the family Symbiodiniaceae contain a number of species and play an important role in the establishment of coral reef ecosystems in oligotrophic marine waters. Effrenium voratum is likely an exclusively free-living and heterotrophic species of Symbiodiniaceae. How this species responds and acclimates to warming is largely unknown. The present study experimentally established the phenotypic landscapes related to the photobleaching and recovery processes of Effrenium voratum SCS01 following thermal stress. We found that thermal stress bleached the plastids of E. voratum SCS01 and caused the cells to become lighter in color. Thereafter, the bleached cells recovered rapidly when they returned to the optimal temperature. The dominant life form of E. voratum SCS01 shifted from mastigote cells to coccoid cells then returned to mastigote cells. Transcriptome analysis revealed that the photobleaching of E. voratum SCS01 was due to increased degradation and decreased biosynthesis of photosynthetic pigments. The thermally induced life form changes were related to the downregulation of genes for cell motility. Our results revealed the mechanism of photobleaching in E. voratum SCS01 and indicated life form transformation as a newly identified survival strategy of Effrenium voratum SCS01 under thermal stress.

The chemical profile and biological activity of different extracts of Sapindus mukorossi Gaertn. against Cutibacterium acnes - Min-Ping Wei; Jin-Dan Qiu; Lu Li; Yun-Fei Xie; Ya-Hui Guo; Hang Yu; Yu-Liang Cheng; He Qian; Wei-Rong Yao (Natural Product Research, 2021)

Flavonoids from Eucommia ulmoides and their in vitro hepatoprotective activities - Weixing Huang; Liqin Ding; Nan Zhang; Wei Li; Kazuo Koike; Feng Qiu (Natural Product Research, 2021)

Identification and validation of two major QTLs for spike compactness and length in bread wheat (Triticum aestivum L.) showing pleiotropic effects on yield-related traits - Tao Li; Guangbing Deng; Yan Su; Zhao Yang; Yanyan Tang; Jinhui Wang; Xvebing Qiu; Xi Pu; Jun Li; Zehou Liu; Haili Zhang; Junjun Liang; et al. (Theoretical and Applied Genetics, 2021)

Correction to: Considerations for Updates to ICH Q1 and Q5C Stability Guidelines: Embracing Current Technology and Risk Assessment Strategies - Megan E. McMahon; Alexander Abbott; Yelizaveta Babayan; Jenny Carhart; Chi-wan Chen; Elke Debie; Mingkun Fu; Cherokee Hoaglund-Hyzer; Andrew Lennard; Hanlin Li; Tony Mazzeo; Lori McCaig; et al. (The AAPS Journal, 2021)

Considerations for Updates to ICH Q1 and Q5C Stability Guidelines: Embracing Current Technology and Risk Assessment Strategies - Megan E. McMahon; Alexander Abbott; Yelizaveta Babayan; Jenny Carhart; Chi-wan Chen; Elke Debie; Mingkun Fu; Cherokee Hoaglund-Hyzer; Andrew Lennard; Hanlin Li; Tony Mazzeo; Lori McCaig; et al. (The AAPS Journal, 2021)

Three-dimensional reconstruction of pore canals in the cuticle of the brown planthopper - Dan-Ting Li; Jian-Sheng Guo; Xin-Qiu Wang; Bernard Moussian; Chuan-Xi Zhang (Science China Life Sciences, 2021)

Transcriptome analysis reveals differing response and tolerance mechanism of EPSPS and GAT genes among transgenic soybeans - Bing-Fu Guo; Hui-Long Hong; Li-Ping Sun; Yong Guo; Li-Juan Qiu (Molecular Biology Reports, 2021)

Differences in pathogenicity and physiologic races between Pyricularia oryzae isolates from indica and japonica rice varieties - Zhong-na Hao; Zhen Zhang; Hai-ping Qiu; Rong-yao Chai; Shi-zhen Wang; Yan-li Wang; Jiao-yu Wang; Guo-chang Sun (Journal of Plant Pathology, 2021)

Untargeted metabolomic analysis of urine samples for diagnosis of inherited metabolic disorders - Hao Liu; Jiang Zhu; Qiu Li; Dongjuan Wang; Kexing Wan; Zhaojian Yuan; Juan Zhang; Lin Zou; Xiaoyan He; Jingkun Miao (Functional & Integrative Genomics, 2021)

Effect of Soil Properties and Aging Time on Oral and Inhalation Bioaccessibility of Copper Oxide Nanoparticles in Soils - Shiwei Li; Yanhua Qiu; Minghui Chang; Zongquan Sun; Fang He; Helian Li (Bulletin of Environmental Contamination and Toxicology, 2021)

High-throughput sequencing revealed the expression profile and potential key molecules of the circular RNAs involved in the process of hypoxic adaptation in Tibetan chickens - Zengrong Zhang; Mohan Qiu; Huarui Du; Qingyun Li; Wu Gan; Xia Xiong; Chunlin Yu; Han Peng; Bo Xia; Xiaoyan Song; Li Yang; Chenming Hu; et al. (Biologia, 2021)

Complete genome sequence of a novel mitovirus from the phytopathogenic fungus Fusarium oxysporum - Jing Wang; Chengjun Li; Rui Qiu; Xiaojie Li; Jun Zhao; Jingke Bai; Yuguo Chen; Shujun Li (Archives of Virology, 2021)

Synthesizing a Novel Zr/Fe/Al-Incorporated Cross-linked Chitosan as Absorbent for Effective Removal of Fluoride from Aqueous Solution - Feng Li; Yingting Zhang; Bo Xu; Yongqiang Liu; Haiyan Qiu; Guihong Lan; Qianxia Xu (Water, Air, & Soil Pollution, 2021)

Daily Streamflow Forecasting Based on Flow Pattern Recognition - Fang-Fang Li; Han Cao; Chun-Feng Hao; Jun Qiu (Water Resources Management, 2021)

Genetic and molecular characterization of determinant of six-rowed spike of barley carrying vrs1.a4 - Jin-Hui Wang; Zhen-Mei Xu; Xue-Bing Qiu; Li-Lan Li; Shui-Yang Yu; Tao Li; Yan-Yan Tang; Xi Pu; Juan-Yu Zhang; Hai-Li Zhang; Jun-Jun Liang; Ya-Wei Tang; et al. (Theoretical and Applied Genetics, 2021)

Dynamic Neutrophil–Lymphocyte Ratios Predict Short-term Prognostic Outcome of Thrombolysis in Patients with Acute Ischemic Stroke - Yiyun Weng; Jingyu Hu; Junli Ren; Honghao Huang; Chenguang Yang; Jiamin Shen; Wenjing Pan; Fangyue Sun; Haojie Qiu; Yufan Gao; Shengqi Li; Xuerong Huang; et al. (Neurotoxicity Research, 2021)

Inhibition of miR-1298-5p attenuates sepsis lung injury by targeting SOCS6 - Jian Ma; Li-Yun Xu; Qiu-Hong Sun; Xiao-Yu Wan; BingLi (Molecular and Cellular Biochemistry, 2021)

A network pharmacology study with molecular docking to investigate the possibility of licorice against posttraumatic stress disorder - Zhi-Kun Qiu; Zhi-Ting Liu; Jia-Li Pang; Han-Biao Wu; Xu Liu; Ze-Min Yang; Xiong Li; Ji-Sheng Chen (Metabolic Brain Disease, 2021)

γ-Aminobutyric Acid Participates in the Adult-Phase Adventitious Rooting Recalcitrance - Xu Li; Xiaozhao Xu; Fei Shen; Wei Li; Changpeng Qiu; Ting Wu; Yi Wang; Xuefeng Xu; Zhenhai Han; Xinzhong Zhang (Journal of Plant Growth Regulation, 2021)
In many tree species especially the rooting-recalcitrant woody perennials, the adventitious root (AR) in the juvenile phase can be easily induced by exogenous auxin, but AR formation becomes recalcitrant in the adult phase. Also, it is reported that the γ-aminobutyric acid (GABA) inhibits primary root growth in Arabidopsis and the AR formation in poplar ( Populus ssp). So far, how GABA affects or is affected by the ontogenetic phase or auxin remains unclear. Here, we used an apple rootstock, Malus xiaojinensis, and tobacco ( Nicotiana benthamiana ) to investigate this question. We first analyzed the content of GABA, the activity of GABA synthetic enzyme GAD, and the expression of the coding gene MxGADs, respectively, in leafy cuttings of juvenile and adult phase. Next, the effect of exogenous GABA on AR formation was examined in in vitro shoots of M. xiaojinensis and tobacco. Interestingly, significant and consistent increases in GABA concentration, GAD activity, and expression of MxGAD genes in response to exogenous indole butyric acid (IBA) were detected in adult-phase cuttings, but not in juvenile-phase cuttings. Exogenous GABA application inhibited the AR formation by delaying rooting time and reducing root number and the total root length in in vitro shoots of both M. xiaojinensis and tobacco. The expression of MxPIN members increased in response to IBA application, but these changes were restrained by the addition of GABA. These results indicate that both the loss of juvenility and IBA are required to trigger GABA accumulation. GABA may affect the AR formation as a co-actor by inhibiting polar auxin transport. Together, these findings facilitate the understanding of the regulatory network among GABA, juvenility, and auxin signaling on the AR formation.

Reductive and adsorptive elimination of U(VI) ions in aqueous solution by SFeS@Biochar composites - Renrong Liu; Hai Wang; Li Han; Baowei Hu; Muqing Qiu (Environmental Science and Pollution Research, 2021)

Inhibition of Maternal c-Src Ameliorates the Male Offspring Hypertension by Suppressing Inflammation and Neurotransmitters in the Paraventricular Nucleus - Qing Su; Xiao-Jing Yu; Qing Yang; Xiao-Min Wang; Wen-Jie Xia; Hong-Bao Li; Kai-Li Liu; Qiu-Yue Yi; Yu-Ming Kang (Cardiovascular Toxicology, 2021)

Irradiation-related longitudinal white matter atrophy underlies cognitive impairment in patients with nasopharyngeal carcinoma - Xiaoshan Lin; Linquan Tang; Mengjie Li; MingLi Wang; Zheng Guo; Xiaofei Lv; Yingwei Qiu (Brain Imaging and Behavior, 2021)

Research on the evolution law of permafrost under the influence of urbanization based on remote sensing technology - Kai Gao; Yanjie Liu; Lin Ding; Shuai Huang; Kaichi Qiu; Zhongpan Wang; Yang Yang; Xing Liu; Jiaxin Li (Earthquake Engineering and Engineering Vibration, 2021)

Performance of rectangular closed diaphragm walls in gently sloping liquefiable deposits subjected to different earthquake ground motions - Jianlei Zhang; Qiangong Cheng; Yan Li; Yuheng Qiu; Yufeng Wang; Jiujiang Wu (Earthquake Engineering and Engineering Vibration, 2021)

Non-consumptive effects of Encarsia formosa on the reproduction and metabolism of the whitefly Bemisia tabaci - Ze-Yun Fan; Zhan-Peng Zhu; Jing Peng; Xin-Yi Chen; Zi-Tong Lu; Hui-Peng Pan; Bao-Li Qiu (BioControl, 2021)

Circular RNA circ_Cabin1 promotes DNA damage in multiple mouse organs via inhibition of non-homologous end-joining repair upon PM2.5 exposure - Huixian Zeng; Meizhen Li; Qiuhan Hua; Yufei Liu; Yueting Shao; Qinqin Diao; Yihui Ling; Han Zhang; Miaoyun Qiu; Jialu Zhu; Xun Li; Rong Zhang; et al. (Archives of Toxicology, 2021)

Sinanaerobacter chloroacetimidivorans gen. nov., sp. nov., an obligate anaerobic bacterium isolated from anaerobic sludge - Yixuan Bao; Junwei Liu; Xuan Zhang; Peng Lei; Jiguo Qiu; Jian He; Na Li (Antonie van Leeuwenhoek, 2021)

Evaluation of the difference in water quality between urban and suburban rivers based on self-organizing map - Yaqi Jiang; Herong Gui; Chen Li; Jiayu Chen; Chen Chen; Chunlei wang; Honghai Zhao; Yan Guo; Jiying Xu; Jun Li; Huili Qiu (Acta Geophysica, 2021)

Genomic and transcriptomic insights into the habitat adaptation of the diazotrophic paddy‐field cyanobacterium Nostoc sphaeroides - Zhen Chen; Jin‐Long Shang; Shengwei Hou; Tao Li; Qi Li; Yi‐Wen Yang; Wolfgang R. Hess; Bao‐Sheng Qiu (Environmental Microbiology, 2021)
Summary Nitrogen‐fixing cyanobacteria are common in paddy fields, one of the most productive wetland ecosystems. Here, we present the complete genome of Nostoc sphaeroides, a paddy‐field diazotroph used for food and medicine for more than 1700 years and deciphered the transcriptional regulation during the developmental transition from hormogonia to vegetative filaments with heterocysts. The genome of N. sphaeroides consists of one circular chromosome (6.48 Mb), one of the largest ever reported megaplasmids (2.34 Mb), and seven plasmids. Multiple gene families involved in the adaption to high solar radiation and water fluctuation conditions were found expanded, while genes involved in anoxic adaptation and phosphonate utilization are located on the megaplasmid, suggesting its indispensable role in environmental adaptation. Distinct gene expression patterns were observed during the light‐intensity‐regulated transition from hormogonia to vegetative filaments, specifically, genes encoding proteins involved in photosynthetic light reaction, carbon fixation, nitrogen metabolism and heterocyst differentiation were significantly upregulated, whereas genes related to cell motility were down‐regulated. Our results provide genomic and transcriptomic insights into the adaptation of a filamentous nitrogen‐fixing cyanobacterium to the highly dynamic paddy‐field habitat, suggesting N. sphaeroides as an excellent system to understand the transition from aquatic to terrestrial habitats and to support sustainable rice production.

Effects of α-linolenic acid intake on blood lipid profiles：a systematic review and meta-analysis of randomized controlled trials - Hao Yue; Bin Qiu; Min Jia; Wei Liu; Xiao-fei Guo; Na Li; Zhi-xiang Xu; Fang-ling Du; Tongcheng Xu; Duo Li (Critical Reviews in Food Science and Nutrition, 2021)

Cysestermerol A, a rare stilbene sestermer with significant hypoglycemic activities from Cynodon dactylon - Feng Wang; Li Zhang; Bi-Jun Li; Qiu-Ming Liang; A-Li Chen; Zhen-Feng Fang; Shu-Mei Wang (Natural Product Research, 2021)

Inhibition of Candida albicans and induced vaginitis by sapindus water extract - Lu Li; Jindan Qiu; Minping Wei; Yunfei Xie; Hang Yu; Yahui Guo; Yuliang Cheng; Weirong Yao (Natural Product Research, 2021)

Extensional tectonics and North China Craton destruction: Insights from the magnetic susceptibility anisotropy (AMS) of granite and metamorphic core complex - Wei Lin; Jipei Zeng; Lingtong Meng; Huabiao Qiu; Wei Wei; Zhiheng Ren; Yang Chu; Shuangjian Li; Chao Song; Qincheng Wang (Science China Earth Sciences, 2021)

Co-editing PINK1 and DJ-1 Genes Via Adeno-Associated Virus-Delivered CRISPR/Cas9 System in Adult Monkey Brain Elicits Classical Parkinsonian Phenotype - Hao Li; Shihao Wu; Xia Ma; Xiao Li; Tianlin Cheng; Zhifang Chen; Jing Wu; Longbao Lv; Ling Li; Liqi Xu; Wenchao Wang; Yingzhou Hu; et al. (Neuroscience Bulletin, 2021)
Whether direct manipulation of Parkinson’s disease (PD) risk genes in the adult monkey brain can elicit a Parkinsonian phenotype remains an unsolved issue. Here, we used an adeno-associated virus serotype 9 (AAV9)-delivered CRISPR/Cas9 system to directly co-edit PINK1 and DJ-1 genes in the substantia nigras (SNs) of two monkey groups: an old group and a middle-aged group. After the operation, the old group exhibited all the classic PD symptoms, including bradykinesia, tremor, and postural instability, accompanied by key pathological hallmarks of PD, such as severe nigral dopaminergic neuron loss (>64%) and evident α-synuclein pathology in the gene-edited SN. In contrast, the phenotype of their middle-aged counterparts, which also showed clear PD symptoms and pathological hallmarks, were less severe. In addition to the higher final total PD scores and more severe pathological changes, the old group were also more susceptible to gene editing by showing a faster process of PD progression. These results suggested that both genetic and aging factors played important roles in the development of PD in the monkeys. Taken together, this system can effectively develop a large number of genetically-edited PD monkeys in a short time (6–10 months), and thus provides a practical transgenic monkey model for future PD studies.

Identification of QTL for resistance to head smut in maize (Zea mays. L) - Hongbo Qiu; Kang Tan; Chunhong Li; Tao Shen; Zhi Zhang (Euphytica, 2021)

Trace metal contamination in soils from mountain regions across China: spatial distribution, sources, and potential drivers - Haijian Bing; Shaojun Qiu; Xin Tian; Jun Li; He Zhu; Yanhong Wu; Gan Zhang (Soil Ecology Letters, 2021)

Characterization of a transcription factor SlNAC7 gene from Suaeda liaotungensis and its role in stress tolerance - Hong-Fei Wang; Hong-Yan Shan; He Shi; Dan-Dan Wu; Tong-Tong Li; Qiu-Li Li (Journal of Plant Research, 2021)

Soft Urinary Bladder Phantom for Endoscopic Training - Eunjin Choi; Frank Waldbillig; Moonkwang Jeong; Dandan Li; Rahul Goyal; Patricia Weber; Arkadiusz Miernik; Britta Grüne; Simon Hein; Rodrigo Suarez-Ibarrola; Maximilian Christian Kriegmair; Tian Qiu (Annals of Biomedical Engineering, 2021)
Bladder cancer (BC) is the main disease in the urinary tract with a high recurrence rate and it is diagnosed by cystoscopy (CY). To train the CY procedures, a realistic bladder phantom with correct anatomy and physiological properties is highly required. Here, we report a soft bladder phantom (FlexBlad) that mimics many important features of a human bladder. Under filling, it shows a large volume expansion of more than 300% with a tunable compliance in the range of 12.2 ± 2.8 – 32.7 ± 5.4 mL cmH 2 O −1 by engineering the thickness of the bladder wall. By 3D printing and multi-step molding, detailed anatomical structures are represented on the inner bladder wall, including sub-millimeter blood vessels and reconfigurable bladder tumors. Endoscopic inspection and tumor biopsy were successfully performed. A multi-center study was carried out, where two groups of urologists with different experience levels executed consecutive CYs in the phantom and filled in questionnaires. The learning curves reveal that the FlexBlad has a positive effect in the endourological training across different skill levels. The statistical results validate the usability of the phantom as a valuable educational tool, and the dynamic feature expands its use as a versatile endoscopic training platform.

Soft Liver Phantom with a Hollow Biliary System - Xiangzhou Tan; Dandan Li; Moonkwang Jeong; Tingting Yu; Zhichao Ma; Saif Afat; Karl-Enrst Grund; Tian Qiu (Annals of Biomedical Engineering, 2021)
Hepatobiliary interventions are regarded as difficult minimally-invasive procedures that require experience and skills of physicians. To facilitate the surgical training, we develop a soft, high-fidelity and durable liver phantom with detailed morphology. The phantom is anatomically accurate and feasible for the multi-modality medical imaging, including computer tomography (CT), ultrasound, and endoscopy. The CT results show that the phantom resembles the detailed anatomy of real livers including the biliary ducts, with a spatial root mean square error (RMSE) of 1.7 ± 0.7 mm and 0.9 ± 0.2 mm for the biliary duct and the liver outer shape, respectively. The sonographic signals and the endoscopic appearance highly mimic those of the real organ. An electric sensing system was developed for the real-time quantitative tracking of the transhepatic puncturing needle. The fabrication method herein is accurate and reproducible, and the needle tracking system offers a robust and general approach to evaluate the centesis outcome.

A fungal sirtuin modulates development and virulence in the insect pathogen, Beauveria bassiana - Qing Cai; Li Tian; Jia‐Tao Xie; Qiu‐Ying Huang; Ming‐Guang Feng; Nemat O. Keyhani (Environmental Microbiology, 2021)
Summary Chromatin transitions are mediated in part by acetylation/deacetylation post‐translational modifications of histones. Histone deacetylases, e.g. sirtuins (Sir‐proteins), repress transcription via promotion of heterochromatin formation. Here, we characterize the Sir2 class III histone deacetylase ( BbSir2 ) in the environmentally and economically important fungal insect pathogen, Beauveria bassiana . BbSir2 is shown to contribute to the deacetylation of lysine residues on H3 and H4 histones. Targeted gene knockout of BbSir2 resulted in impaired asexual development, reduced abilities to utilize various carbon/nitrogen sources, reduced tolerance to oxidative, heat, and UV stress, and attenuated virulence. ΔBbSir2 cells showed disrupted cell cycle development and abnormal hyphal septation patterns. Proteomic protein acetylation analyses of wild type and ΔBbSir2 cells revealed the differential abundance of 462 proteins and altered (hyper‐ or hypo‐) acetylation of 436 lysine residues on 350 proteins. Bioinformatic analyses revealed enrichment in pathways involved in carbon/nitrogen metabolism, cell cycle control and cell rescue, defence and mitochondrial functioning. Critical targets involved in virulence included LysM effector proteins and a benzoquinone oxidoreductase implicated in detoxification of cuticular compounds. These data indicate broad effects of BbSir2 on fungal development and stress response, with identification of discrete targets that can account for the observed (decreased) virulence phenotype.

An innovative extraction methodology of active deformation areas based on sentinel-1 SAR dataset: the catalonia case study - Zhiwei Qiu; Oriol Monserrat; Michele Crosetto; Vrinda Krishnakumar; Li Zhou (International Journal of Remote Sensing, 2021)

Identification of glutathione transferase gene associated with partial resistance to Sclerotinia stem rot of soybean using genome-wide association and linkage mapping - Zou Jianan; Wenjing Li; Yuting Zhang; Wei Song; Haipeng Jiang; Jingyun Zhao; Yuhang Zhan; Weili Teng; Lijuan Qiu; Xue Zhao; Yingpeng Han (Theoretical and Applied Genetics, 2021)

Fine mapping of a powdery mildew resistance gene MlIW39 derived from wild emmer wheat (Triticum turgidum ssp. dicoccoides) - Lina Qiu; Nannan Liu; Huifang Wang; Xiaohan Shi; Feng Li; Qiang Zhang; Weidong Wang; Weilong Guo; Zhaorong Hu; Hongjie Li; Jun Ma; Qixin Sun; et al. (Theoretical and Applied Genetics, 2021)

Identification and candidate gene mining of HvSS1, a novel qualitative locus on chromosome 6H, regulating the uppermost internode elongation in barley (Hordeum vulgare L.) - Xi Pu; Yanyan Tang; Meihao Zhang; Tao Li; Xvebing Qiu; Juanyu Zhang; Jinhui Wang; Lilan Li; Zhao Yang; Yan Su; Haili Zhang; Junjun Liang; et al. (Theoretical and Applied Genetics, 2021)

Integrated transcriptome and miRNA sequencing approaches provide insights into salt tolerance in allotriploid Populus cathayana - Tong Qiu; Kang Du; Yanchun Jing; Qingqing Zeng; Zhao Liu; Yun Li; Yongyu Ren; Jun Yang; Xiangyang Kang (Planta, 2021)

Correction to: CYP3A5 and CYP3A7 genetic polymorphisms affect tacrolimus concentration in pediatric patients with nephrotic syndrome - Hongxia Liu; Qinxia Xu; Wenyan Huang; Qi Zhao; Zhihu Jiang; Xinyu Kuang; Zhiling Li; Huajun Sun; Xiaoyan Qiu (European Journal of Clinical Pharmacology, 2021)

Higher photochemical production of bromophenol by quinone-like substances extracted from humic substances using a new emodin-imprinted polymer - Hui Liu; Xiaojun Qiu; Zhi Li; Xiaomei Zhu; Bing Sun; Xiaoxing Zhang (Environmental Chemistry Letters, 2021)

Whole brain volume and cortical thickness abnormalities in Wilson’s disease: a clinical correlation study - Yukun Song; Lin Zou; Jing Zhao; Xiangxue Zhou; Yingqian Huang; Haishan Qiu; Haiwei Han; Zhiyun Yang; Xunhua Li; Xiaoying Tang; Jianping Chu (Brain Imaging and Behavior, 2021)

Long Non-coding RNA Expression Profile in Broiler Liver with Cadmium-Induced Oxidative Damage - Chunlin Yu; Chaowu Yang; Xiaoyan Song; Jingjing Li; Han Peng; Mohan Qiu; Li Yang; Huarui Du; Xiaosong Jiang; Yiping Liu (Biological Trace Element Research, 2021)

Parameter Sensitivity Analysis of the WRF-Hydro Modeling System for Streamflow Simulation: a Case Study in Semi-Humid and Semi-Arid Catchments of Northern China - Yuchen Liu; Jia Liu; Chuanzhe Li; Fuliang Yu; Wei Wang; Qingtai Qiu (Asia-Pacific Journal of Atmospheric Sciences, 2021)

Genome sequencing and comparative genome analysis of 6 hypervirulent Klebsiella pneumoniae strains isolated in China - Ling Du; Jiaxue Zhang; Pin Liu; Xuan Li; Kewen Su; Lingyue Yuan; Zhongshuang Zhang; Dan Peng; Yingli Li; Jingfu Qiu (Archives of Microbiology, 2021)

Maricaulis alexandrii sp. nov., a novel active bioflocculants-bearing and dimorphic prosthecate bacterium isolated from marine phycosphere - Xiao-ling Zhang; Min Qi; Qiu-hong Li; Zhen-dong Cui; Qiao Yang (Antonie van Leeuwenhoek, 2021)

Geographic and subsequent biotic isolations led to a diversity anomaly of section Heterotropa (genus Asarum : Aristolochiaceae) in insular versus continental regions of the Sino‐Japanese Floristic Region - Daiki Takahashi; Shota Sakaguchi; Yu Feng; Yuji Isagi; Ying‐Xiong Qiu; Pan Li; Rui‐Sen Lu; Chang‐Tse Lu; Shih‐Wen Chung; Yang‐Shan Lin; Yun‐Chao Chen; Atsushi J. Nagano; et al. (Journal of Biogeography, 2021)
Aim The Sino‐Japanese Floristic Region has extremely high species diversity with respect to temperate plants; however, the reasons for this diversity are poorly understood because most studies have only considered geographic isolation caused by climatic oscillations. In some plant groups, high floral trait diversity and uneven species diversity between insular systems and the continental area suggest other factors may have important roles too. The primary purpose of this study is to reveal how abiotic and biotic factors have shaped the species diversity anomaly of Heterotropa between the insular systems and the continental area. Location The Sino‐Japanese Floristic Region. Taxon Section Heterotropa (genus Asarum ; Aristolochiaceae). Methods Using ddRAD‐seq and chloroplast genome data, we built a time‐calibrated phylogenetic tree including 79 species. We estimated the patterns of floral traits (flowering time and floral size) evolution using macroevolutionary modelling, and tested the correlation of speciation rate with the trait evolution rates. Finally, we estimated the isolation factors of all taxa pairs and sister‐taxa pairs based on distribution range and floral traits. Results Phylogenetic analysis indicated that Heterotropa was diverged into two clades (continental clade and insular clade) in the Miocene, and the major subclades corresponded to geographic entities. Most rate shifts accelerating floral trait's evolution occurred during the Pleistocene period. Evolution rate of floral traits showed positive correlation with the speciation rate. Large proportion of taxa in the insular clade are distributed allopatrically. Several sister pairs showed floral trait divergence with geographic overlap. Main Conclusions The diversification of Heterotropa appears to have been triggered by geographic and climatic events, and subsequent repeated floral trait evolution with and without geographic isolation. Furthermore, the high species diversity in the insular systems would have been formed by the repeated range fragmentations and contractions. Our study demonstrates the importance of multidimensional studies to understand the diversification process of temperate plants in the Sino‐Japanese Floristic Region.

Length-Based Assessment of Fish Stocks in a Data-Poor, Jointly Exploited (China and Vietnam) Fishing Ground, Northern South China Sea - Kui Zhang; Jiajun Li; Gang Hou; Zirong Huang; Dengfu Shi; Zuozhi Chen; Yongsong Qiu (Frontiers in Marine Science, 2021)
The Beibu Gulf is one of the most important fishing grounds in the South China Sea (SCS), and the fisheries resources in this area are exploited by both China and Vietnam. In recent decades, some indications of overfishing have appeared, including declining catch rates, frequently changing catch composition, and shrinking body sizes in main commercial fish species. Due to limited data availability, only a small subset of exploited fish stocks in this area has been assessed. Here, we applied two length-based methods, electronic length frequency analysis (ELEFAN) and length-based Bayesian biomass estimation (LBB), to stock assessment of nine exploited fish species in the Beibu Gulf. There were total 53, 652 length records of 30 target stocks used in this study during the survey period from 1960 to 2015. The results showed that the two length-based methods presented different ability in estimating exploitation rate ( E ), and the estimated E ranged from 0.34 to 0.87 using ELEFAN method while ranged from 0.26 to 0.86 using LBB method. The prior information from ELEFAN method was effective for LBB method, as there were significant differences in 66.7% of the 30 target stocks in estimated L inf , and 93.3% in estimated B / B MSY , using LBB method with and without prior information. The estimated L c / L c_opt and B / B MSY of LBB method suggest a pressing situation for the fisheries in the Beibu Gulf, as 86.7% of the 30 target stocks had been suffering from growth overfishing ( L c / L c_opt < 1), and 83.3% had been overexploited or fully exploited ( B / B MSY ≤ 1.2). In addition, we suggest using both ELEFAN and LBB methods to fit length-frequency data of data-poor fish stocks because they are complementary in estimating management reference points. We also emphasize collaboration mechanism should be established by China and Vietnam for the sustainability and recovery of fishery resources in the Beibu Gulf.

Risk factors for sleep disorders in patients undergoing peritoneal dialysis - Gui-Ling Liu; Qiu-Nan Zhan; You-Lu Zhao; Zu-Ying Xiong; Jin-Lan Liao; Ye-Ping Ren; Qin Wang; Li-Ping Duan; Zhao-Xia Zheng; Li Hao; Jie Dong (Sleep and Biological Rhythms, 2021)
Sleep disorders in patients with end-stage renal disease are common but have rarely been reported in previous studies. Therefore, we examined the prevalence of sleep disorders and the risk factors for declining sleep quality in patients undergoing peritoneal dialysis (PD). A multicenter prospective cohort study was conducted at five PD centers across different provinces in China. A total of 449 patients who underwent PD between March to November 2013 were enrolled. Demographic data, laboratory indicators, presence of depression, and sleep assessment data were collected. Sleep questionnaires reflecting five categories of sleep disorders, namely, insomnia, restless legs syndrome, excessive daytime sleepiness, possible narcolepsy, and sleepwalking and nightmares, were administered at baseline and at 24 months postoperatively. Sleep disorders were diagnosed when a patient had at least one sleep problem. At baseline, 335 (74.6%) patients had at least one type of sleep disorder. Depression, diabetes mellitus (DM), and male were found to be associated with the presence of a sleep disorder. At follow-up, the prevalence of insomnia, restless legs syndrome, and excessive daytime sleepiness had significantly increased in 285 patients. Furthermore, cardiovascular disease (CVD) was found to be associated with the presence of sleep disorders in patients with one or more disorders at baseline, whereas a low serum albumin level was found to be associated with sleep disorders in patients without any sleep disorders at baseline. The prevalence of sleep disorders was relatively high among PD patients at baseline and increased afterthe2-year follow-up. Depression, DM, and male were associated with all sleep disorders at baseline. CVD was associated with the presence of a sleep disorder at baseline and worse sleep quality at the 2-year follow-up; whereas a low serum albumin level was associated with the risk of acquiring a sleep disorder at the 2-year follow-up among patients with normal sleep status at baseline.

Poisson’s ratios and S-wave velocities of the Xishancun landslide, Sichuan, China, inferred from high-frequency receiver functions of local earthquakes - Zigen Wei; Risheng Chu; Zhiwei Li; Minhan Sheng; Qiu Zeng (Science China Earth Sciences, 2021)

Short-term waterlogging-induced autophagy in root cells of wheat can inhibit programmed cell death - Li-Lang Zhou; Kai-Yue Gao; Li-Sha Cheng; Yue-Li Wang; Yi-Keng Cheng; Qiu-Tao Xu; Xiang-Yi Deng; Ji-Wei Li; Fang-Zhu Mei; Zhu-Qing Zhou (Protoplasma, 2021)

Comparative analysis of sRNAs, degradome and transcriptomics in sweet sorghum reveals the regulatory roles of miRNAs in Cd accumulation and tolerance - Weitao Jia; Kangqi Lin; Tengxue Lou; Juanjuan Feng; Sulian Lv; Ping Jiang; Ze Yi; Xuan Zhang; Duoliya Wang; Zijing Guo; Yetao Tang; Rongliang Qiu; et al. (Planta, 2021)

PPM1F in Dentate Gyrus Modulates Anxiety-Related Behaviors by Regulating BDNF Expression via AKT/JNK/p-H3S10 Pathway - Fantao Meng; Jing Liu; Juanjuan Dai; Haifeng Lian; Shujun Jiang; Qiongyu Li; Min Wu; Wentao Wang; Dan Wang; Di Zhao; Cuilan Liu; Changyun Qiu; et al. (Molecular Neurobiology, 2021)

Design, synthesis, and antidepressant/anticonvulsant activities of 3H-benzo[f]chromen chalcone derivatives - Qiu-Wan Tan; Li-Ya He; Zhi-Wen He; Wei-Hua Liu; Shan-Shan Zhang; Lin Lin; Hong-Li Yang; Li-Ping Guan (Medicinal Chemistry Research, 2021)

Comparison of lead adsorption characteristics onto soil-derived particulate organic matter versus humic acid - Qingjie Zhao; Yong Qiu; Tian Lan; Jianhong Li; Boling Li; Zhipeng Wu; Long Chen; Ruichun Liu; Yujie Zhou; Weidong Wu (Journal of Soils and Sediments, 2021)

Study on the desulfurization performance of iron/ethanolamine/deep eutectic solvent system - Xinpeng Liu; Baohua Wang; Yahui Qiu; Xiaole Dong; Yixin Song; Qingmei Meng; Menghong Li (Environmental Science and Pollution Research, 2021)

Soil and ambient air mercury as an indicator of coal-fired power plant emissions: a case study in North China - Zhonggen Li; Xufeng Chen; Wenli Liu; Taishan Li; Guangle Qiu; Haiyu Yan; Mingmeng Wang; Ji Chen; Guangyi Sun; Qingfeng Wang; Xinbin Feng (Environmental Science and Pollution Research, 2021)

The Immune Regulatory Effect of Boron on Ostrich Chick Splenic Lymphocytes - Xiaoting Zhang; Ke Xiao; Weiwei Qiu; Jiaxiang Wang; Peng Li; Kemei Peng (Biological Trace Element Research, 2021)

Distributions of Total Mercury and Methylmercury in Dragonflies from a Large, Abandoned Mercury Mining Region in China - Gaoen Wu; Shunlin Tang; Jialiang Han; Chan Li; Lin Liu; Xiaohang Xu; Zhidong Xu; Zhuo Chen; Yajie Wang; Guangle Qiu (Archives of Environmental Contamination and Toxicology, 2021)

Forging or casting: new evidence of iron production in the Chengdu Plain in the Han dynasty - Mengyi Zhang; Linjie Ge; Tian Qiu; Qianqian Gan; Bo Yang; Yuniu Li (Archaeological and Anthropological Sciences, 2021)

The relationship between atmospheric potential gradient descent along with negative potential gradient anomalies and earthquake precursors - Xiaobing Jin; Junwei Bu; Jingxuan Tian; Xiaoxiao Wu; Guilan Qiu; Li Ma; Zhongming Chen; Balin Xu; Liang Zhang (Arabian Journal of Geosciences, 2021)

Vertical Profiles of Volatile Organic Compounds in Suburban Shanghai - Yuhan Liu; Hongli Wang; Shengao Jing; Ming Zhou; Shenrong Lou; Kun Qu; Wanyi Qiu; Qian Wang; Shule Li; Yaqin Gao; Yusi Liu; Xiaobing Li; et al. (Advances in Atmospheric Sciences, 2021)

Biochar Derived from Treated Lotus Stem and Adsorption of Phthalic Acid Esters - Ruiling Zhang; Linlin Chen; Binbin Qiu; Xiaojing Sun; Songyan Qin; Bo Wang; Feiyue Li; Lixin Zhao; Zhe Zhu (Water, Air, & Soil Pollution, 2021)

Environmental and techno-economic analyses of bio-jet fuel produced from jatropha and castor oilseeds in China - Haoyu Liu; Chen Zhang; Hailin Tian; Lanyu Li; Xiaonan Wang; Tong Qiu (The International Journal of Life Cycle Assessment, 2021)

Quantitative Proteomics Analysis of Sugarcane Ratoon Crop Chlorosis - Ye-Geng Fan; Rong-Fa Chen; Li-Hang Qiu; Zhong-Feng Zhou; Hui-Wen Zhou; Ji-Guang Wei; Xiu-Peng Song; Ting Luo; Prakash Lakshmanan; Xing Huang; Jian-Ming Wu; Yang-Rui Li (Sugar Tech, 2021)

Systematic analysis of differentially expressed ZmMYB genes related to drought stress in maize - Peng-Yu Zhang; Xiao Qiu; Jia-Xu Fu; Guo-Rui Wang; Li Wei; Tong-Chao Wang (Physiology and Molecular Biology of Plants, 2021)

Genetic Architecture of Childhood Kidney and Urological Diseases in China - Ye Fang; Hua Shi; Tianchao Xiang; Jiaojiao Liu; Jialu Liu; Xiaoshan Tang; Xiaoyan Fang; Jing Chen; Yihui Zhai; Qian Shen; Guomin Li; Li Sun; et al. (Phenomics, 2021)
Kidney disease is manifested in a wide variety of phenotypes, many of which have an important hereditary component. To delineate the genotypic and phenotypic spectrum of pediatric nephropathy, a multicenter registration system is being implemented based on the Chinese Children Genetic Kidney Disease Database (CCGKDD). In this study, all the patients with kidney and urological diseases were recruited from 2014 to 2020. Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features. The genetic diagnosis was confirmed in 883 of 2256 (39.1%) patients from 23 provinces in China. Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome (SRNS, 23.5%), glomerulonephritis (GN, 32.2%), congenital anomalies of the kidney and urinary tract (CAKUT, 21.2%), cystic renal disease (3.9%), renal calcinosis/stone (3.6%), tubulopathy (9.7%), and chronic kidney disease of unknown etiology (CKDu, 5.8%). The pathogenic variants of 105 monogenetic disorders were identified. Ten distinct genomic disorders were identified as pathogenic copy number variants (CNVs) in 11 patients. The diagnostic yield differed by subgroups, and was highest in those with cystic renal disease (66.3%), followed by tubulopathy (58.4%), GN (57.7%), CKDu (43.5%), SRNS (29.2%), renal calcinosis /stone (29.3%) and CAKUT (8.6%). Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions. We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed. Our data demonstrate the utility of family-based exome sequencing, and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease.

Mapping Domain- and Age-Specific Functional Brain Activity for Children’s Cognitive and Affective Development - Lei Hao; Lei Li; Menglu Chen; Jiahua Xu; Min Jiang; Yanpei Wang; Linhua Jiang; Xu Chen; Jiang Qiu; Shuping Tan; Jia-Hong Gao; Yong He; et al. (Neuroscience Bulletin, 2021)

DNA Methyltransferase 1 Is Dysregulated in Parkinson’s Disease via Mediation of miR-17 - Hong-Qiu Zhang; Jian-Yong Wang; Zhao-Feng Li; Lei Cui; Shi-Shi Huang; Lan-Bing Zhu; Yue Sun; Rui Yang; Hui-Hui Fan; Xiong Zhang; Jian-Hong Zhu (Molecular Neurobiology, 2021)

Application of radar data assimilation on convective precipitation forecasts based on water vapor retrieval - Zhixin He; Dongyong Wang; Xuexing Qiu; Yang Jiang; Huimin Li; Aiqing Shu (Meteorology and Atmospheric Physics, 2021)
Based on a short-time heavy rainfall in Anhui and the weather research and forecasting (WRF) model, the water vapor in the initial field of the model is retrieved using the statistical relationships of the reflectivity factor from the Doppler weather radar with the relative humidity and hydrometeor. Three-dimensional variational (3DVAR) assimilation method is used to assimilate the radar reflectivity factor and radial velocity, and then the impact of assimilating retrieved water vapor on the analysis and forecast of the torrential rain is assessed. The results show that, after assimilating the retrieved water vapor, the water vapor field in the model is significantly improved. The water vapor content in the middle layer of the model in the analyzed field is increased, corresponding well with the convective region. Meanwhile, the precipitation distribution during this weather process is successfully simulated. The mesoscale characteristics are better presented by the imageries of radar reflectivity factor, and false echoes are partially reduced. Besides, the prediction of short-time heavy rainfall regions is closer to the actual observations. After assimilating the retrieved water vapor, the simulated one-hour accumulated rainfall is closer to the actual observation, and the fraction skill score (FSS) is higher.

Isolation and identification of a 2,3,7,8-Tetrachlorodibenzo-P-dioxin degrading strain and its biochemical degradation pathway - Lina Qiu; Weiwei Zhang; Aijun Gong; Jiandi Li (Journal of Environmental Health Science and Engineering, 2021)
This study aims to find a high-efficiency degradation strain which can biodegrade the 2,3,7,8-Tetrachlorodibenzo-P-dioxin (2,3,7,8-TCDD). In this paper, a new fungus strain was isolated from activated sludge of Dagu Drainage River in Tianjin which was able to degrade 2,3,7,8-TCDD in the medium. Based on its morphology and phylogenetic analysis of its 18S rDNA sequence, the strain was identified as Penicillium sp. QI-1. Response surface methodology using central composite rotatable design of cultural conditions was successfully employed for optimization resulting in 87.9 % degradation of 2,3,7,8-TCDD (1 µg/mL) within 6 days. The optimum condition for degrading 2,3,7,8-TCDD was at 31℃ and pH 7.4. The biodegradation process was fitted to a first-order kinetic model. The kinetic equation was C t =0.939e − 0.133t and its half-life was 5.21d. The fungus strain degraded 2,3,7,8-TCDD to form intermediates, they were 4,5-Dichloro-1,2-benzoquinone, 4,5-Dichlorocatechol, 2-Hydrooxy-1,4-benzoquinone, 1,2,4-Trihydroxybenzene and β-ketoadipic acid. A novel degradation pathway for 2,3,7,8-TCDD was proposed based on analysis of these metabolites. The results suggest that Penicillium sp. QI-1 may be an ideal microorganism for biodegradation of the 2,3,7,8-TCDD-contaminated environments.

Magnolol attenuates inflammatory pain by inhibiting sodium currents in mouse dorsal root ganglion neurons - Lu-lu Zhang; Jie Qiu; Jiang-ru Hong; Xiu-qi Xu; Guang-qin Zhang; Guang Li (Inflammopharmacology, 2021)

Shattering-resistance of an elite soybean variety ‘Heihe 43’ and identification of shattering-resistant genes - Dezhi Han; Jianan Han; Siqi Jiang; Bohong Su; Bo Zhang; Zhangxiong Liu; Hongrui Yan; Li-Juan Qiu (Euphytica, 2021)

Assessment of different ventilation strategies on ventilation performance in immersed tunnels - Linjie Li; Qiaozhi Qiu; Xuefu Zhang; Pai Xu; Jialiang Liu; Yilin Li; Chuangang Fan (Environmental Science and Pollution Research, 2021)

Fracture recognition in ultrasonic logging images via unsupervised segmentation network - Wei Zhang; Tong Wu; Zhipeng Li; Shiyuan Liu; Ao Qiu; Yanjun Li; Yibing Shi (Earth Science Informatics, 2021)

Correction to: Synthetic antimicrobial agents inhibit aflatoxin production - Jing Li; Qing-Qing Zhi; Jie Zhang; Xiao-Yu Yuan; Li-Hong Jia; Yu-Lin Wan; Qiu-Yun Liu; Jian-Rong Shi; Zhu-Mei He (Brazilian Journal of Microbiology, 2021)

Synthetic antimicrobial agents inhibit aflatoxin production - Jing Li; Qing-Qing Zhi; Jie Zhang; Xiao-Yu Yuan; Li-Hong Jia; Yu-Lin Wan; Qiu-Yun Liu; Jian-Rong Shi; Zhu-Mei He (Brazilian Journal of Microbiology, 2021)

Agricultural Non-point Source Pollution in China: Evaluation, Convergence Characteristics and Spatial Effects - Wenwen Qiu; Zhangbao Zhong; Zhaoliang Li (Chinese Geographical Science, 2021)

Comparison of in Vascular Bioreactors and In Vivo Models of Degradation and Cellular Response of Mg–Zn–Mn Stents - Ningling Zhou; Ping Li; Hua Qiu; Jin Wang; Nan Huang; Ansha Zhao; Juan Wang (Annals of Biomedical Engineering, 2021)

Effects of prenatal exposure to bisphenols on newborn leucocyte telomere length: a prospective birth cohort study in China - Jun Liang; Yantao Shao; Dongping Huang; Chunxiu Yang; Tao Liu; Xiaoyun Zeng; Chunling Li; Zhenghua Tang; Jennifer Tan Hui Juan; Yanye Song; Shun Liu; Xiaoqiang Qiu (Environmental Science and Pollution Research, 2021)

What’s the best way to achieve successful mainstream partial nitritation-anammox application? - Songkai Qiu; Zebing Li; Yuansheng Hu; Lin Shi; Rui Liu; Lei Shi; Lujun Chen; Xinmin Zhan (Critical Reviews in Environmental Science and Technology, 2021)

Development of a pyrF-based counterselectable system for targeted gene deletion in Streptomyces rimosus - Yiying Yang; Qingqing Sun; Yang Liu; Hanzhi Yin; Wenping Yang; Yang Wang; Ying Liu; Yuxian Li; Shen Pang; Wenxi Liu; Qian Zhang; Fang Yuan; et al. (Journal of Zhejiang University-SCIENCE B, 2021)

Effects of Co-Applications of Biochar and Solid Digestate on Enzyme Activities and Heavy Metals Bioavailability in Cd-Polluted Greenhouse Soil - Shuaixing Xue; Fengfen Chen; Yuying Wang; Zhijiang Shao; Congguang Zhang; Ling Qiu; Yi Ran; Li He (Water, Air, & Soil Pollution, 2021)

Effect of the inclined pile-soil arch in a soil landslide reinforced with anti-sliding piles - Zizhen Liu; Zhixin Yan; Xiaogang Wang; Jiwei Li; Zhanhong Qiu (Natural Hazards, 2021)

Associations between SNP83 of phosphodiesterase 4D gene and carotid atherosclerosis in a southern Chinese Han population: a case–control study - Liu-yu Liu; Dong-can Mo; Jian-li Li; Yi-ying Jiang; Guo-qiu Zhou; Dong-dong Jiang; Li-jie Chen; Xiao-ju Wu; Jiao-xing Li; Man Luo (Mammalian Genome, 2021)

Microbiological profiles and antimicrobial resistance patterns of pediatric bloodstream pathogens in China, 2016–2018 - Yue Qiu; Junwen Yang; Yiping Chen; Jinhong Yang; Qingxiong Zhu; Chunhui Zhu; Shuangjie Li; Jing Liu; Chaomin Wan; Yu Zhu; Minxia Chen; Yi Xu; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Correction to: Central Blockade of E-Prostanoid 3 Receptor Ameliorated Hypertension Partially by Attenuating Oxidative Stress and Inflammation in the Hypothalamic Paraventricular Nucleus of Spontaneously Hypertensive Rats - Fang-Fang Wang; Juan Bai; Xiao-Jing Yu; Xiao-Lian Shi; Jin-Jun Liu; Kai-Li Liu; Li-Yan Fu; Qing Su; Hong-Bao Li; Kai B. Kang; Qiu-Yue Yi; Shu-Qiu Wang; et al. (Cardiovascular Toxicology, 2021)

Central Blockade of E-Prostanoid 3 Receptor Ameliorated Hypertension Partially by Attenuating Oxidative Stress and Inflammation in the Hypothalamic Paraventricular Nucleus of Spontaneously Hypertensive Rats - Fang-Fang Wang; Juan Ba; Xiao-Jing Yu; Xiao-Lian Shi; Jin-Jun Liu; Kai-Li Liu; Li-Yan Fu; Qing Su; Hong-Bao Li; Kai B. Kang; Qiu-Yue Yi; Shu-Qiu Wang; et al. (Cardiovascular Toxicology, 2021)

Dydrogesterone Affects the Transcription of Genes in Innate Immune and Coagulation Cascade in Zebrafish Embryos - Wen-Jun Shi; Yan‑Qiu Liang; Jian‑Liang Zhao; Li‑Xin Hu; Guo-Yong Huang; Guang-Guo Ying (Bulletin of Environmental Contamination and Toxicology, 2021)

Sediment Characteristics, Sources, and Transport Patterns in Kompong Som Bay, Cambodia: Indications from Grain Size and Heavy Minerals - Jinqing Liu; Xiaoying Chen; Ping Yin; Ke Cao; Fei Gao; Yuanku Meng; Jiandong Qiu; Meina Li (Journal of Ocean University of China, 2021)

Modes of exploitation of atmospheric water resources in the Qinghai–Tibet plateau - Fang‐Fang Li; Kang Zhao; Hou‐Liang Lu; Guang‐Qian Wang; Jun Qiu (International Journal of Climatology, 2021)
Known as “China's Water Tower,” the Qinghai–Tibet Plateau (QTP) becomes warm and humid in the short term but faces drought in the long term because of global climate change. Atmospheric water resources seem to be the only choice in the QTP region to alleviate drought conditions. Analysis of water vapour distribution and evaluation of exploitation modes of atmospheric water resources are carried out in this study. Different exploitation modes of atmospheric water resources including routine, selective, and emergency‐oriented exploitation are distinguished using water vapour budget and its distribution entropy. Zoning of the QTP indicates that routine exploitation, that is, long‐term, continuous, and fixed‐point exploitation, can only be carried out in its eastern part, while the middle and western parts are suitable for selective exploitation. Such entropy‐based assessment and zoning can be used as a reference for the exploitation of atmospheric water in the QTP in the future. Furthermore, the proposed zoning criteria can be used to estimate the exploitability of atmospheric water resources.

Long non-coding RNA NEAT1 regulates endothelial functions in subclinical hypothyroidism through miR-126/TRAF7 pathway - Li Wang; Jingzhi Liu; Kunna Lu; Yuyu Qiu; Xiaoxia Li; Feng Yue; Xinhuan Zhang (Human Cell, 2021)

Plasma remediation for petroleum pollution of the sea - ZiKe Qiu; ZhanYi Zhang; ZhiXing Mo; Meng Li; ChangMing Du (Waste Disposal & Sustainable Energy, 2021)

A New Rock Brittleness Index Based on the Characteristics of Complete Stress–Strain Behaviors - Zhihao Kuang; Shili Qiu; Shaojun Li; Shihui Du; Yong Huang; Xingqiang Chen (Rock Mechanics and Rock Engineering, 2021)

A Fluorescent Visual Proton Donor and Photoacid Sterilant Based on Sulfonate‐conjugated BODIPY - Abbas Mohammed Ali; Jian Shao; Jia-Xin Wang; Qiu-Yun Chen; Yang Li; Ling-Ling Qu (Journal of Fluorescence, 2021)

High-Level Expression and Purification of Melittin in Escherichia coli Using SUMO Fusion Partner - Qiu-chi Chen; Lei Liu; Tian-Yi Yu; Lu Tang; Mo-li Yin; Wen-he Zhu; Xiu-yun Jiang; Hui-yan Wang (International Journal of Peptide Research and Therapeutics, 2021)

A Radiomics Signature to Quantitatively Analyze COVID-19-Infected Pulmonary Lesions - Jiajun Qiu; Shaoliang Peng; Jin Yin; Junren Wang; Jingwen Jiang; Zhenlin Li; Huan Song; Wei Zhang (Interdisciplinary Sciences: Computational Life Sciences, 2021)

Effects of fenvalerate concentrations and its chiral isomers on bacterial community structure in the sediment environment of aquaculture ponds - Chao Song; Jingwei Zhang; Xi Chen; Gengdong Hu; Limin Fan; Guang Yang; Tian Li; Liping Qiu; Jiazhang Chen; Longxiang Fang (Environmental Science and Pollution Research, 2021)

Antimonate removal by diatomite modified with Fe-Mn oxides: application and mechanism study - Qiu-Yi Dong; Yu-Chun Fang; Bin Tan; Aura Ontiveros-Valencia; Ang Li; He-Ping Zhao (Environmental Science and Pollution Research, 2021)

Effects of alkali, autoclaving, and Fe+ autoclaving pretreatment on anaerobic digestion performance of coking sludge from the perspective of sludge extracts and methane production - Zhao Yang; Xiaoyue Kang; Ben Chen; Guanglei Qiu; Jingyue Wei; Fusheng Li; Chaohai Wei (Environmental Science and Pollution Research, 2021)

Occurrence and risk evaluation of organophosphorus flame retardants in two urban rivers in Yangtze River Delta - Enmiao Jiao; Xiaohui Hu; Li Li; Hua Zhang; Zhiliang Zhu; Daqiang Yin; Yanling Qiu (Environmental Monitoring and Assessment, 2021)

Transcriptome profiling reveals candidate genes associated with cold stress in mulberry - Acheampong Adolf; Li Liu; Michael Ackah; Yang Li; Qiuxia Du; Danyan Zheng; Peng Guo; Yisu Shi; Qiang Lin; Changyu Qiu; Weiguo Zhao (Brazilian Journal of Botany, 2021)

Fluoride Exposure and Blood Pressure: a Systematic Review and Meta-Analysis - Meng Li; Yannan Zhao; Xiaolin Tian; Penghui Liu; Jiaxin Xie; Nisha Dong; Jing Feng; Yi Gao; Ye Fan; Yulan Qiu; Fengjie Tian; Xiaoyan Yan (Biological Trace Element Research, 2021)

Identification of Colletotrichum brevisporum causing fruit rot in yellow passion fruit (Passiflora edulis f. flavicarpa) in China - Fang Qiu; Xi Li; Chang Ping Xie; Jing Li; Fei Qing Zheng (Australasian Plant Pathology, 2021)

Rapid diagnosis of Ralstonia solanacearum infection sweet potato in China by loop-mediated isothermal amplification - Huawei Li; Hong Zhang; Zhonghua Liu; Zhijian Lin; Yongxiang Qiu; Hao Tang; Sixin Qiu (Archives of Microbiology, 2021)

Measuring solar irradiance profiles in the Arctic sea ice using fiber optic spectrometry via inclined holes - Zexia Qiu; Hangzhou Wang; Tao Li; Hong Song; Yuanqian Wu; Tingting Yan; Ying Chen (Acta Oceanologica Sinica, 2021)

Application of data mining to lagging deformation prediction of the underwater shield tunnel - Xin Li; Yiguo Xue; Daohong Qiu; Xinmin Ma; Cong Qu; Binghua Zhou; Fanmeng Kong (Marine Georesources & Geotechnology, 2021)

In Situ Saturating Mutagenesis Screening Identifies a Functional Genomic Locus that Regulates Ucp1 Expression - Yan Qiu; Xiaojian Liu; Yingmin Sun; Shuang Li; Yuda Wei; Cheng Tian; Qiurong Ding (Phenomics, 2021)

Methylation of RILP in lung cancer promotes tumor cell proliferation and invasion - Jianbo Lin; Yi Zhuo; Yinhe Yin; Linbin Qiu; Xu Li; Fancai Lai (Molecular and Cellular Biochemistry, 2021)

Paeonol ameliorates CFA-induced inflammatory pain by inhibiting HMGB1/TLR4/NF-κB p65 pathway - Chen Qiu; Liu-Di Yang; Wen Yu; Dan-Dan Tian; Mei-Rong Gao; Wen-Ju Wang; Xu-Bo Li; Yu-Mei Wu; Min Wang (Metabolic Brain Disease, 2021)

Evaluation and application of an efficient plant DNA extraction protocol for laboratory and field testing - Qi Wang; Xiaoxia Shen; Tian Qiu; Wei Wu; Lin Li; Zhi’an Wang; Huixia Shou (Journal of Zhejiang University-SCIENCE B, 2021)

Target-specific mutations efficiency at multiple loci of CRISPR/Cas9 system using one sgRNA in soybean - Ling Zhang; Yingzhe Wang; Tong Li; Hongmei Qiu; Zhengjun Xia; Yingshan Dong (Transgenic Research, 2021)

Downregulation of miR-296-3p by highly pathogenic porcine reproductive and respiratory syndrome virus activates the IRF1/TNF-α signaling axis in porcine alveolar macrophages - Yanbing Zhang; Xiao Xiang; Yan Lu; Hui Li; Abdul Wahaab; Mona Sharma; Ke Liu; Jianchao Wei; Zongjie Li; Donghua Shao; Beibei Li; Zhiyong Ma; et al. (Archives of Virology, 2021)

Dominant factor of dry‐wet change in China since 1960s - Jinqin Xu; Dandan Wang; Xinfa Qiu; Yan Zeng; Xiaochen Zhu; Mengxi Li; Yongjian He; Guoping Shi (International Journal of Climatology, 2021)
The dry‐wet climate conditions of an area are mainly determined by the water input (e.g., precipitation, P) and output (e.g., potential evapotranspiration, PET). Based on three dry‐wet indices and the differential equation, this study designed a new attribution method to quantify the contributions of P and PET to the dry‐wet change, so as to determine the dominant factors of the dry‐wet change over whole China (CHINA) and various hydroclimate regions (i.e., arid region, AR; semi‐arid region, SAR; semi‐humid region, SHR; and humid region, HR) during 1960–2018 and six interdecadal periods. Results showed that the overall weak drying in CHINA was dominated by an increase in PET, while climate humidification in AR and HR was dominated by an increase in P, climate drying in SHR was dominated by the reduced P, and the weak drying in SAR was co‐dominated by P and PET during 1960–2018. The dominant factors of dry‐wet change over CHINA and each hydroclimate region varied in different decades. Briefly, climate humidification in CHINA and various hydroclimate regions was basically dominated by P in different decades, and the drying was mainly dominated by P in the 1960s–1980s, but the contribution of PET to climate drying began to become prominent after the 1980s. Besides, we found that P contributed more to dry‐wet change than PET on the station and regional scales, but the contribution of P to climate drying on a national scale was underestimated to some extent due to the regional offset effect of the increase/decrease in P during 1960–2018, as well as in the 1990s. These findings implied that the importance of research on the regional or local scale, and equal attention should be paid to the effects of P and PET changes in the future drought or dry‐wet change research.

Toonamicrocarpavarin, a new tirucallane-type triterpenoid from Toona Ciliata - Ling Zhang; Jianjun Xia; Yanqing Duan; Keyi Wei; Rui Gao; Dasan Li; Xiaomin Liu; Tiandong Zhang; Minghua Qiu (Natural Product Research, 2021)