Effects of Elevation on Ecological Stoichiometry of Plant Leaves, Litter, and Soils in Pseudotsuga sinensis Forest in the Karst Mountain region, Southwest China - He Bin; Qing Li; Ping Zhang; Wangjun Li; Xiaohui Xue; Shun Zou; Qunsheng Zhang (Journal of Soil Science and Plant Nutrition, 2022)

Dissecting the role of cell signaling versus CD8+ T cell modulation in propranolol antitumor activity - Wei Li; Jielin Wan; Cuiyu Chen; Chengfang Zhou; Ping Liao; Qian Hu; Jiali Hu; Yang Wang; Yu Zhang; Cong Peng; Yuanfei Huang; Weihua Huang; et al. (Journal of Molecular Medicine, 2022)

Oxytocin Receptor in Cerebellar Purkinje Cells Does Not Engage in Autism-Related Behaviors - Li-Ping Shen; Wei Li; Ling-Zhu Pei; Jun Yin; Shu-Tao Xie; Hong-Zhao Li; Chao Yan; Jian-Jun Wang; Qipeng Zhang; Xiao-Yang Zhang; Jing-Ning Zhu (The Cerebellum, 2022)

Updated taxonomy of Chinese Clavaria subg. Syncoryne (Clavariaceae, Agaricales): description of two new species and one newly recorded species - Jun Yan; Gui-Wu Li; Wen-Hao Liu; Zuo-Hong Chen; Ping Zhang (Mycological Progress, 2022)

Transport process and mechanism of the Hongshiyan rock avalanche triggered by the 2014 Ludian earthquake, China - Shi-lin Zhang; Yue-ping Yin; Hai-bo Li; Wen-pei Wang; Jia-wen Zhou (Landslides, 2022)

Ketone Body Rescued Seizure Behavior of LRP1 Deficiency in Drosophila by Modulating Glutamate Transport - Jin-Ming Zhang; Ming-Jie Chen; Jiong-Hui He; Ya-Ping Li; Zhi-Cai Li; Zi-Jing Ye; Yong-Hui Bao; Bing-Jun Huang; Wen-Jie Zhang; Ping Kwan; Yu-Ling Mao; Jing-da Qiao (Journal of Molecular Neuroscience, 2022)

Two-stage cultivation of Scenedesmus acuminatus with nitrogen and sulfur for growth and lipid accumulation - Ying Zhang; Hongxiao Shen; Ping Zhong; Zhenzhu Huang; Ning Xu; Aifen Li (Journal of Applied Phycology, 2022)

Feed types affect the growth, nutrient utilization, digestive capabilities, and endocrine functions of Megalobrama amblycephala: a comparative study between pelleted and extruded feed - Chao-Fan He; Xiang-Fei Li; Guang-Zhen Jiang; Ling Zhang; Miao Sun; Ya-Ping Ge; Wei-Liang Chen; Wen-Bin Liu (Fish Physiology and Biochemistry, 2022)

Monitoring and control methods of harmful algal blooms in Chinese freshwater system: a review - Shengjun Xu; Ping Lyu; Xiaoxu Zheng; Haijun Yang; Bing Xia; Hui Li; Hao Zhang; Shuanglong Ma (Environmental Science and Pollution Research, 2022)

Microfluidic preparation of a novel phoxim nanoemulsion pesticide against Spodoptera litura - Zong-Nan Li; Yu-Xuan Zhang; Zhi-Ang Zhang; Lian-Han Pan; Ping Li; Yan Xu; Sheng Sheng; Fu-An Wu; Jun Wang (Environmental Science and Pollution Research, 2022)

Altered effective connectivity within the cingulo-frontal-parietal cognitive attention networks in chronic low back pain: a dynamic causal modeling study - Cui Ping Mao; Hua Juan Yang; Qiu Juan Zhang; Quan Xin Yang; Xiao Hui Li (Brain Imaging and Behavior, 2022)

Fertility conversion between cytoplasmic maintainer lines and restorer lines through molecular marker-assisted selection in pepper (Capsicum annuum L.) - Fu-Sen Ren; Hai-Feng Yang; Yu-Shun Jiao; Rui-Ping Zhang; Zhi-Wei Guo; He-Juan Liu; Qiang Sun; Xi-Jun Li; Xiu-Fang Tan; Bei Zhang; Jun-Qi Zhen; Yan-Qi Dong (Biologia, 2022)

ML323, a USP1 inhibitor triggers cell cycle arrest, apoptosis and autophagy in esophageal squamous cell carcinoma cells - Yaxin Sun; Beibei Sha; Wenjing Huang; Miaomiao Li; Shan Zhao; Yuan Zhang; Jie Yan; Zheng Li; Jingwen Tang; Peiyan Duan; Jianxiang Shi; Pei Li; et al. (Apoptosis, 2022)

Belowground processes and sustainability in agroecosystems with intercropping - Rui-Peng Yu; Hao Yang; Yi Xing; Wei-Ping Zhang; Hans Lambers; Long Li (Plant and Soil, 2022)

PPARγ alleviates peritoneal fibrosis progression along with promoting GLUT1 expression and suppressing peritoneal mesothelial cell proliferation - Junxia Feng; Meizhi Lu; Wenhao Li; Jingchun Li; Ping Meng; Zukai Li; Xuejuan Gao; Yunfang Zhang (Molecular and Cellular Biochemistry, 2022)
Objective Peritoneal fibrosis (PF) is commonly induced by bioincompatible dialysate exposure during peritoneal dialysis, but the underlying mechanisms remain elusive. This study aimed to investigate the roles of peroxisome proliferator-activated receptor gamma (PPARγ) in PF pathogenesis. Methods Rat and cellular PF models were established by high glucose dialysate and lipopolysaccharide treatments. Serum creatinine, urea nitrogen, and glucose contents were detected by ELISA. Histological evaluation was done through H&E and Masson staining. GLUT1, PPARγ, and other protein expression were measured by qRT-PCR, western blotting, and IHC. PPARγ and GLUT1 subcellular distribution were detected using confocal microscopy. Cell proliferation was assessed by MTT and Edu staining. Results Serum creatinine, urea nitrogen and glucose, and PPARγ and GLUT1 expression in rat PF model were reduced by PPARγ agonists Rosiglitazone or 15d-PGJ2 and elevated by antagonist GW9662. Rosiglitazone or 15d-PGJ2 repressed and GW9662 aggravated peritoneal fibrosis in rat PF model. PPARγ and GLUT1 were mainly localized in nucleus and cytosols of peritoneal mesothelial cells, respectively, which were reduced in cellular PF model, enhanced by Rosiglitazone or 15d-PGJ2, and repressed by GW9662. TGF-β and a-SMA expression was elevated in cellular PF model, which was inhibited by Rosiglitazone or 15d-PGJ2 and promoted by GW9662. PPARγ silencing reduced GLUT1, elevated a-SMA and TGF-b expression, and promoted peritoneal mesothelial cell proliferation, which were oppositely changed by PPARγ overexpression. Conclusion PPARγ inhibited high glucose-induced peritoneal fibrosis progression through elevating GLUT1 expression and repressing peritoneal mesothelial cell proliferation.

The α5-nAChR/PD-L1 axis facilitates lung adenocarcinoma cell migration and invasion - Ping Zhu; Guiyu Kang; Yang Jiao; Chengzhi Gui; Huiping Fan; Xiangying Li; Yanfei Jia; Lulu Zhang; Xiaoli Ma (Human Cell, 2022)

Low-carbon production or not? Co-opetition supply chain manufacturers’ production strategy under carbon cap-and-trade policy - Huiqin Zhang; Yuxiang Zhang; Ping Li; Hong Zheng; Zhigang Li (Environment, Development and Sustainability, 2022)

Improved and Flexible HDR Editing by Targeting Introns in iPSCs - Juan Fu; Ya-Wen Fu; Juan-Juan Zhao; Zhi-Xue Yang; Si-Ang Li; Guo-Hua Li; Zi-Jun Quan; Feng Zhang; Jian-Ping Zhang; Xiao-Bing Zhang; Chang-Kai Sun (Stem Cell Reviews and Reports, 2022)
Highly efficient gene knockout (KO) editing of CRISPR–Cas9 has been achieved in iPSCs, whereas homology-directed repair (HDR)-mediated precise gene knock-in (KI) and high-level expression are still bottlenecks for the clinical applications of iPSCs. Here, we developed a novel editing strategy that targets introns. By targeting the intron before the stop codon, this approach tolerates reading frameshift mutations caused by nonhomologous end-joining (NHEJ)-mediated indels, thereby maintaining gene integrity without damaging the non-HDR-edited allele. Furthermore, to increase the flexibility and screen for the best intron-targeting sgRNA, we designed an HDR donor with an artificial intron in place of the endogenous intron. The presence of artificial introns, particularly an intron that carries an enhancer element, significantly increased the reporter expression levels in iPSCs compared to the intron-deleted control. In addition, a combination of the small molecules M3814 and trichostatin A (TSA) significantly improves HDR efficiency by inhibiting NHEJ. These results should find applications in gene therapy and basic research, such as creating reporter cell lines.

CaMKIIα Signaling Is Required for the Neuroprotective Effects of Dl-3-n-Butylphthalide in Alzheimer’s Disease - Bing-qiu Li; Ling-zhi Xu; Fang-yu Li; Ying Li; Yu Zhao; Heng Zhang; Mei-na Quan; Jian-ping Jia (Molecular Neurobiology, 2022)

Breast Cancer Awareness Based on Health Information Literacy and Influential Factors among Female Nursing Students in China - Shu Yang; Ping Li; Lin Yu; Na Liu; Jie Wang; Pingping Guo; Xuehui Zhang; Wei Zhang (Journal of Cancer Education, 2022)

C2CD4A/B variants in the predisposition of lung cancer in the Chinese Han population - Feifei Han; Lu Qian; Yi Zhang; Ping Liu; Rui Li; Mingwei Chen (Functional & Integrative Genomics, 2022)

Effects of long-term exposure of norfloxacin on the HPG and HPT axes in juvenile common carp - Si-Qi Zhang; Xue-Li Zhao; Shu-Wen He; Shao-Ying Xing; Zhi-Han Cao; Ping Li; Zhi-Hua Li (Environmental Science and Pollution Research, 2022)

Rapid triage for ischemic stroke: a machine learning-driven approach in the context of predictive, preventive and personalised medicine - Yulu Zheng; Zheng Guo; Yanbo Zhang; Jianjing Shang; Leilei Yu; Ping Fu; Yizhi Liu; Xingang Li; Hao Wang; Ling Ren; Wei Zhang; Haifeng Hou; et al. (EPMA Journal, 2022)
Background Recognising the early signs of ischemic stroke (IS) in emergency settings has been challenging. Machine learning (ML), a robust tool for predictive, preventive and personalised medicine (PPPM/3PM), presents a possible solution for this issue and produces accurate predictions for real-time data processing. Methods This investigation evaluated 4999 IS patients among a total of 10,476 adults included in the initial dataset, and 1076 IS subjects among 3935 participants in the external validation dataset. Six ML-based models for the prediction of IS were trained on the initial dataset of 10,476 participants (split participants into a training set [80%] and an internal validation set [20%]). Selected clinical laboratory features routinely assessed at admission were used to inform the models. Model performance was mainly evaluated by the area under the receiver operating characteristic (AUC) curve. Additional techniques—permutation feature importance (PFI), local interpretable model-agnostic explanations (LIME), and SHapley Additive exPlanations (SHAP)—were applied for explaining the black-box ML models. Results Fifteen routine haematological and biochemical features were selected to establish ML-based models for the prediction of IS. The XGBoost-based model achieved the highest predictive performance, reaching AUCs of 0.91 (0.90–0.92) and 0.92 (0.91–0.93) in the internal and external datasets respectively. PFI globally revealed that demographic feature age, routine haematological parameters, haemoglobin and neutrophil count, and biochemical analytes total protein and high-density lipoprotein cholesterol were more influential on the model’s prediction. LIME and SHAP showed similar local feature attribution explanations. Conclusion In the context of PPPM/3PM, we used the selected predictors obtained from the results of common blood tests to develop and validate ML-based models for the diagnosis of IS. The XGBoost-based model offers the most accurate prediction. By incorporating the individualised patient profile, this prediction tool is simple and quick to administer. This is promising to support subjective decision making in resource-limited settings or primary care, thereby shortening the time window for the treatment, and improving outcomes after IS.

Comment on “Relationship of Circulating Copper Level with Gestational Diabetes Mellitus: a Meta-analysis and Systemic Review” - Shu-ping Li; Xiao-ping Zhang; Xin-hong Cui; Li-juan Zhao; Yan-jun Rong (Biological Trace Element Research, 2022)

Failure mechanisms and risk mitigation of check dams on the Chinese Loess Plateau: A case study at the Gutun Gully - Rui-jun Jiang; Mao-sheng Zhang; Li Feng; Ping-ping Sun (Journal of Mountain Science, 2022)

Expanding the clinical spectrum of adult-onset neuronal intranuclear inclusion disease - Yuwen Cao; Jingying Wu; Yunhua Yue; Chao Zhang; Shihua Liu; Ping Zhong; Shige Wang; Xiaojun Huang; Weiping Deng; Jing Pan; Lan Zheng; Qing Liu; et al. (Acta Neurologica Belgica, 2022)

Mycorrhizal fungi alleviate acidification‐induced phosphorus limitation: Evidence from a decade‐long field experiment of simulated acid deposition in a tropical forest in south China - Yuanliu Hu; Ji Chen; Dafeng Hui; Ying‐Ping Wang; Jianling Li; Jingwen Chen; Guoyin Chen; Yiren Zhu; Leiyi Zhang; Deqiang Zhang; Qi Deng (Global Change Biology, 2022)
South China has been experiencing very high rate of acid deposition and severe soil acidification in recent decades, which has been proposed to exacerbate the regional ecosystem phosphorus (P) limitation. We conducted a 10‐year field experiment of simulated acid deposition to examine how acidification impacts seasonal changes of different soil P fractions in a tropical forest with highly acidic soils in south China. As expected, acid addition significantly increased occluded P pool but reduced the other more labile P pools in the dry season. In the wet season, however, acid addition did not change microbial P, soluble P and labile organic P pools. Acid addition significantly increased exchangeable Al 3+ and Fe 3+ and the activation of Fe oxides in both seasons. Different from the decline of microbial abundance in the dry season, acid addition increased ectomycorrhizal fungi and its ratio to arbuscular mycorrhiza fungi in the wet season, which significantly stimulated phosphomonoesterase activities and likely promoted the dissolution of occluded P. Our results suggest that, even in already highly acidic soils, the acidification‐induced P limitation could be alleviated by stimulating ectomycorrhizal fungi and phosphomonoesterase activities. The differential responses and microbial controls of seasonal soil P transformation revealed here should be implemented into ecosystem biogeochemical model for predicting plant productivity under future acid deposition scenarios.

Episodic Neoproterozoic extension-related magmatism in the Altyn Tagh, NW China: implications for extension and breakup processes of Rodinia supercontinent - Jiang-bo Hao; Chao Wang; Ji-heng Zhang; Liang Liu; Yong-sheng Gai; Hang Li; Zun-pu Yu; Joseph G Meert; Xiao-ping Long; Xiao-kui Sun; Shuai Zhang (International Geology Review, 2022)

Potential Application of Biosurfactant-Producing Bacteria for Bioremediation of Oil Polluted Marine Intertidal Sediments - Ping Guo; Wei-Wei Xu; Dan-Na Wei; Man-Xia Zhang; Jin Zhang; Shi Tang; Bin-Xia Cao; Jian-Guo Lin; Wei Li (Journal of Marine Science and Engineering, 2022)
The removal of oil contaminants in marine intertidal sediments under cold climate is an urgent issue. Although the bioavailability of petroleum hydrocarbons decreases at low temperatures, biosurfactants can promote oil biodegradation. In this study, characteristics of biosurfactants produced by cold-adapted oil-degrading bacteria Planococcus sp. XW-1 were studied. Adding the XW-1 biosurfactant could effectively facilitate the solubility of phenanthrene, pyrene, diesel oil, and crude oil. The solubilization was limited by the number of rings and the molecular weight (WSRphenanthrene = 0.0234; WSRpyrene = 0.0165; WSRdiesel oil = 0.0027; WSRcrude oil = 0.0015). Additional biosurfactants significantly washed out crude oil adsorbed to the sand (reduction from 17.1%, 22.7% to 87.9% and 94.28% in 24 h). With the increase in particle size, the removal efficiency increased from 87.9% to 94.28%. After the addition of biosurfactant, the effect of degradation increased by 20% in 20 days. The results suggest that the biosurfactant-producing bacteria Planococcus sp. XW-1 is a promising candidate used in the in situ bioremediation of petroleum-contaminated intertidal sediment.

Response of xenobiotic biodegradation and metabolic genes in Tribolium castaneum following eugenol exposure - Yonglei Zhang; Shanshan Gao; Ping Zhang; Haidi Sun; Ruixue Lu; Runnan Yu; Yanxiao Li; Kunpeng Zhang; Bin Li (Molecular Genetics and Genomics, 2022)

Revising the species diversity of Hygrophorus section Olivaceoumbrini s.l. (Hygrophoraceae, Agaricales) in China - Hong-Yan Huang; Wen-Hao Zhang; Ting Huang; Shuai Jiang; Yan-Jia Hao; Man Mu; Li-Ping Tang (Mycological Progress, 2022)

The Effects of Ground and Treadmill Running on Energy Metabolism and Muscle Contractile Properties: A Randomized Cross-Over Study - Yuan Zhou; Jian-gang Chen; Xiao-long Li; Xin-liang Pan; Yi-zheng Zhou; Zheng-ao Li; Zhi-cheng Liang; Jia-min Long; Ming-ze Qin; Jing Zhang; Bing Shi; Bing-jun Wan; et al. (Journal of Science in Sport and Exercise, 2022)
Purpose This study aimed to compare the effects of ground and treadmill running on energy metabolism and muscle contractile properties, providing a basis for the general public to choose running venues. Methods Ten male college students (age, 20.10 ± 1.53 years; height, 176.20 ± 5.49 cm; weight, 72.14 ± 8.25 kg; body fat percent, 12.41% ± 4.65%) were recruited in this study. Energy expenditure (EE) was measured using the accelerometer (GT9X) combined with specific estimation equations. Average heart rate (HR) was measured using a heart rate band (Polar). Muscle contractile properties were assessed by measuring muscle displacement (Dm) and contraction velocity (Vc) using tensiomyography (TMG-S1). Blood glucose (Glu) and lactate (Lac) were measured by portable devices (eB-G and Lactate Scout). The running speed was 9 km/h and the duration was 25 min. Two-way ANOVA (protocol × time) was used to analyze the effect of running protocols on energy metabolism and muscle contractile properties. Results EE of treadmill running was significantly higher than EE of ground running (protocol main effect, P < 0.001), and HR of treadmill running was significantly higher than that of ground running in the first testing time (protocol simple effect, P = 0.026; protocol × time interaction P = 0.043). The decrease in Dm of the rectus femoris after treadmill running was significantly higher than that of ground running (protocol main effect, P = 0.009). The interaction of different running protocols and testing times on Lac was significant ( P = 0.025), but all results of the simple effects analysis were not statistically significant ( P > 0.05). Conclusion Our study found a difference in energy expenditure between treadmill and ground running at 9 km/h with duration of 25 min. In addition, treadmills are more likely to cause a decrease in muscle displacement distance of the rectus femoris measured after exercise than ground running. Future studies are needed to further investigate whether the differences are induced by internal metabolism or the environmental conditions of running.

Residential proximity to major roadway and progression in physical disability in older adults in China - Jing Hu; Wenqian Chen; Lei Li; Yu Zhang; Hongwei Jiang; Wenhua Liu; Ping Yin (Environmental Science and Pollution Research, 2022)

Analysis on ecological status and spatial–temporal variation of Tamarix chinensis forest based on spectral characteristics and remote sensing vegetation indices - Jin Wang; Ping Han; Yanhua Zhang; Jinyu Li; Linxu Xu; Xue Shen; Zhigang Yang; Sisi Xu; Guangxue Li; Feiyong Chen (Environmental Science and Pollution Research, 2022)

Urinary phthalate metabolites in pregnant women: occurrences, related factors, and association with maternal hormones - Wei Wu; Zhi-li Ma; Fang Yang; Ping Wu; De-xin Zhang; Rong Zeng; Dan-ling Sun; Liu Cao (Environmental Science and Pollution Research, 2022)

Chemical constituents of Viscum coloratum (Kom.) Nakai and their cytotoxic activities - Ying-Ying Chen; Jiang-Ping Hou; Ling Huang; Afsar Khan; Fei-Fei Xing; Xiao-Han Zhang; De-Feng Han; Shi-Li Yan; Gui-Dong Cao; Qi-Yang Jiao; Dejie Liu; Xuwei Zhu; et al. (Natural Product Research, 2022)

Two new dammarane-type triterpenoids from the green walnut husks of Juglans mandshurica Maxim - Yuan-Yuan Zhou; Hui-Rui Gao; Hong-Juan Song; Dan-Da Ma; Xiao-Juan Zhang; Yan-Ping Sun; Yan Liu; Xiao-Li Wang; Bing-You Yang; Hai-Xue Kuang (Natural Product Research, 2022)

Dissection of the practical soybean breeding pipeline by developing ZDX1, a high-throughput functional array - Rujian Sun; Bincheng Sun; Yu Tian; Shanshan Su; Yong Zhang; Wanhai Zhang; Jingshun Wang; Ping Yu; Bingfu Guo; Huihui Li; Yanfei Li; Huawei Gao; et al. (Theoretical and Applied Genetics, 2022)
Key message We developed the ZDX1 high-throughput functional soybean array for high accuracy evaluation and selection of both parents and progeny, which can greatly accelerate soybean breeding. Abstract Microarray technology facilitates rapid, accurate, and economical genotyping. Here, using resequencing data from 2214 representative soybean accessions, we developed the high-throughput functional array ZDX1, containing 158,959 SNPs, covering 90.92% of soybean genes and sites related to important traits. By application of the array, a total of 817 accessions were genotyped, including three subpopulations of candidate parental lines, parental lines and their progeny from practical breeding. The fixed SNPs were identified in progeny, indicating artificial selection during the breeding process. By identifying functional sites of target traits, novel soybean cyst nematode-resistant progeny and maturity-related novel sources were identified by allele combinations, demonstrating that functional sites provide an efficient method for the rapid screening of desirable traits or gene sources. Notably, we found that the breeding index (BI) was a good indicator for progeny selection. Superior progeny were derived from the combination of distantly related parents, with at least one parent having a higher BI. Furthermore, new combinations based on good performance were proposed for further breeding after excluding redundant and closely related parents. Genomic best linear unbiased prediction (GBLUP) analysis was the best analysis method and achieved the highest accuracy in predicting four traits when comparing SNPs in genic regions rather than whole genomic or intergenic SNPs. The prediction accuracy was improved by 32.1% by using progeny to expand the training population. Collectively, a versatile assay demonstrated that the functional ZDX1 array provided efficient information for the design and optimization of a breeding pipeline for accelerated soybean breeding.

Fine mapping of powdery mildew resistance gene MlWE74 derived from wild emmer wheat (Triticum turgidum ssp. dicoccoides) in an NBS-LRR gene cluster - Keyu Zhu; Miaomiao Li; Haibin Wu; Deyun Zhang; Lingli Dong; Qiuhong Wu; Yongxing Chen; Jingzhong Xie; Ping Lu; Guanghao Guo; Huaizhi Zhang; Panpan Zhang; et al. (Theoretical and Applied Genetics, 2022)

Anterior Cingulate Cortex Mediates Hyperalgesia and Anxiety Induced by Chronic Pancreatitis in Rats - Dan Ren; Jia-Ni Li; Xin-Tong Qiu; Fa-Ping Wan; Zhen-Yu Wu; Bo-Yuan Fan; Ming-Ming Zhang; Tao Chen; Hui Li; Yang Bai; Yun-Qing Li (Neuroscience Bulletin, 2022)
Central sensitization is essential in maintaining chronic pain induced by chronic pancreatitis (CP), but cortical modulation of painful CP remains elusive. Here, we examined the role of the anterior cingulate cortex (ACC) in the pathogenesis of abdominal hyperalgesia in a rat model of CP induced by intraductal administration of trinitrobenzene sulfonic acid (TNBS). TNBS treatment resulted in long-term abdominal hyperalgesia and anxiety in rats. Morphological data indicated that painful CP induced a significant increase in FOS-expressing neurons in the nucleus tractus solitarii (NTS) and ACC, and some FOS-expressing neurons in the NTS projected to the ACC. In addition, a larger portion of ascending fibers from the NTS innervated pyramidal neurons, the neural subpopulation primarily expressing FOS under the condition of painful CP, rather than GABAergic neurons within the ACC. CP rats showed increased expression of vesicular glutamate transporter 1, and increased membrane trafficking and phosphorylation of the N -methyl-D-aspartate receptor (NMDAR) subunit NR2B and the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) subunit GluR1 within the ACC. Microinjection of NMDAR and AMPAR antagonists into the ACC to block excitatory synaptic transmission significantly attenuated abdominal hyperalgesia in CP rats, which was similar to the analgesic effect of endomorphins injected into the ACC. Specifically inhibiting the excitability of ACC pyramidal cells via chemogenetics reduced both hyperalgesia and comorbid anxiety, whereas activating these neurons via optogenetics failed to aggravate hyperalgesia and anxiety in CP rats. Taken together, these findings provide neurocircuit, biochemical, and behavioral evidence for involvement of the ACC in hyperalgesia and anxiety in CP rats, as well as novel insights into the cortical modulation of painful CP, and highlights the ACC as a potential target for neuromodulatory interventions in the treatment of painful CP.

Targeting GATA1 and p2x7r Locus Binding in Spinal Astrocytes Suppresses Chronic Visceral Pain by Promoting DNA Demethylation - Yan-Yan Wu; Hai-Long Zhang; Xiaomin Lu; Han Du; Yong-Chang Li; Ping-An Zhang; Guang-Yin Xu (Neuroscience Bulletin, 2022)
Irritable bowel syndrome is a gastrointestinal disorder of unknown etiology characterized by widespread, chronic abdominal pain associated with altered bowel movements. Increasing amounts of evidence indicate that injury and inflammation during the neonatal period have long-term effects on tissue structure and function in the adult that may predispose to gastrointestinal diseases. In this study we aimed to investigate how the epigenetic regulation of DNA demethylation of the p2x7r locus guided by the transcription factor GATA binding protein 1 (GATA1) in spinal astrocytes affects chronic visceral pain in adult rats with neonatal colonic inflammation (NCI). The spinal GATA1 targeting to DNA demethylation of p2x7r locus in these rats was assessed by assessing GATA1 function with luciferase assay, chromatin immunoprecipitation, patch clamp, and interference in vitro and in vivo . In addition, a decoy oligodeoxynucleotide was designed and applied to determine the influence of GATA1 on the DNA methylation of a p2x7r CpG island. We showed that NCI caused the induction of GATA1, Ten-eleven translocation 3 (TET3), and purinergic receptors (P2X7Rs) in astrocytes of the spinal dorsal horn, and demonstrated that inhibiting these molecules markedly increased the pain threshold, inhibited the activation of astrocytes, and decreased the spinal sEPSC frequency. NCI also markedly demethylated the p2x7r locus in a manner dependent on the enhancement of both a GATA1–TET3 physical interaction and GATA1 binding at the p2x7r promoter. Importantly, we showed that demethylation of the p2x7r locus (and the attendant increase in P2X7R expression) was reversed upon knockdown of GATA1 or TET3 expression, and demonstrated that a decoy oligodeoxynucleotide that selectively blocked the GATA1 binding site increased the methylation of a CpG island in the p2x7r promoter. These results demonstrate that chronic visceral pain is mediated synergistically by GATA1 and TET3 via a DNA-demethylation mechanism that controls p2x7r transcription in spinal dorsal horn astrocytes, and provide a potential therapeutic strategy by targeting GATA1 and p2x7r locus binding.

Dynamics of nitrogen and phosphorus profile and its driving forces in a subtropical deep reservoir - Cunli Li; Ping Zhang; Guangwei Zhu; Chao Chen; Yucheng Wang; Mengyuan Zhu; Hai Xu; Cuiling Jiang; Wei Zou; Pengcheng Shi; Qing Zheng (Environmental Science and Pollution Research, 2022)

Epigenetic inactivation of ACAT1 promotes epithelial-mesenchymal transition of clear cell renal cell carcinoma - Peipei Han; Shu Wu; Limei Li; Danping Li; Jun Zhao; Haishan Zhang; Yifang Wang; Xuemin Zhong; Zhe Zhang; Ping Li; Liudmila Matskova; Xiaoying Zhou (Genes & Genomics, 2022)

Complete genome analysis of a novel picorna-like virus from a ladybird beetle (Cheilomenes sexmaculata) - Yu-Juan He; Zhuang-Xin Ye; Jian-Ping Chen; Chuan-Xi Zhang; Gang Lu; Jun-Min Li (Archives of Virology, 2022)

Complete genome sequence of a novel arlivirus from a yellow spotted stink bug (Erthesina fullo (Thunberg, 1783)) - Zhuang-Xin Ye; Shao-Min Wang; Gang Lu; Jian-Ping Chen; Chuan-Xi Zhang; Liao-Yuan Xu; Jun-Min Li (Archives of Virology, 2022)

Microplastic Contamination on the Beaches of South China - Bingwen Chai; Yanping Li; Li Wang; Xiao-Tan Zhang; Yi-Ping Wan; Fengyuan Chen; Jie Ma; Wenlu Lan; Ke Pan (Frontiers in Marine Science, 2022)
Microplastics (MPs) have emerged as a pollutant of significant global concern. The sandy beach is a fragile environment that deserves our special attention with regard to MP contamination, as this area is a hotspot that accumulates large quantities of plastic waste. Notably, our current understanding of the MP distribution on beaches and the scale of contamination is far from sufficient. Hence, this study investigated the occurrence and characteristics of MPs on 14 beaches along the coast of South China. The MPs were ubiquitously distributed in the sand, most were small, less than 1 mm. A total of 18 types of polymers were identified in the sand, suggesting that diverse types of MPs are present on the beaches. Polyethylene, polypropylene, and polystyrene were the dominant types of MPs in most of our sampling sites. The MP abundance was higher in the upper layers (0–20 cm) of the beach than in the deeper layers (20–40 cm) of the sampling site when characterized by depth (Yangjiang beach). Our study demonstrates the extent and severity of MP pollution on the beaches of South China and provides implications for future remediation measures. More effort is needed to clarify the vertical distribution of MPs on beaches, especially for those MPs less than 1 μm.

New sesquiterpeniod esters form Blumea balsamifera (L.) DC. and their anti-influenza virus activity - Yan Xiong; Ping Yi; Yuhuan Li; Rongmei Gao; Junlei Chen; Zhanxing Hu; Huayong Lou; Caixia Du; Jiayu Zhang; Yu Zhang; Chunmao Yuan; Liejun Huang; et al. (Natural Product Research, 2022)

A Data-Intensive Numerical Modeling Method for Large-Scale Rock Strata and Its Application in Mining Subsidence Prediction - Ya-Qiang Gong; Guang-Li Guo; Li-Ping Wang; Huai-Zhan Li; Guang-Xue Zhang; Zhen Fang (Rock Mechanics and Rock Engineering, 2022)

Transcriptomic analyses reveal the effect of nitric oxide on the lateral root development and growth of mangrove plant Kandelia obovata - Ming-Yue Wei; Huan Li; You-Hui Zhong; Zhi-Jun Shen; Dong-Na Ma; Chang-Hao Gao; Yi-Ling Liu; Wen-Hua Wang; Jing-Ya Zhang; Yan-Ping You; Hai-Lei Zheng (Plant and Soil, 2022)

Activating PIK3CA postzygotic mutations in segmental overgrowth of muscles with bone involvement in the body extremities - Wen Tian; Liying Sun; Qi Zhang; Junhui Zhao; Yang Guo; Wenyao Zhong; Liu Liu; Katia Meirelles; Sha Tang; Jing Zhang; Yingzhao Huang; Yuehan Yin; et al. (Molecular Genetics and Genomics, 2022)

Bioinformatics Analysis of the MicroRNA-Metabolic Gene Regulatory Network in Neuropathic Pain and Prediction of Corresponding Potential Therapeutics - Huai-Gen Zhang; Li Liu; Zhi-Ping Song; Da-Ying Zhang (Journal of Molecular Neuroscience, 2022)

Detection of Microcystin-LR in the Cells and Natural Lake Water Samples by A Unique Fluorescence-Based Method - Yipeng Liu; Bingyan Li; Huixia Zhang; Yong Liu; Ping Xie (Journal of Fluorescence, 2022)

Biological monitoring and health assessment of 21 metal(loid)s in children and adolescents in Liuzhou City, Southwest China - Yaping Li; Yu Zhang; Meng Yu; Liqin Hu; Ting Zeng; Ling Liu; Limei Wang; Liangqiong Deng; Xiang Li; Ping Liu; Dingyuan Zeng; Surong Mei (Environmental Science and Pollution Research, 2022)

Complete nucleotide sequence of a novel mycovirus infecting Rhizoctonia fumigata AG-Ba isolate C-314 Baishi - Yanqiong Li; Ping Xu; Lifang Zhang; Wurong Chen; Zhen Ren; Genhua Yang; Xiaohan Mo (Archives of Virology, 2022)

Complete nucleotide sequence of a novel alphapartitivirus from Rhizoctonia solani AG-4 HG III isolate SM03 - Yanqiong Li; Wurong Chen; Yanfen Niu; Ping Xu; Lifang Zhang; Shuhui Yu; Genhua Yang; Xiaohan Mo (Archives of Virology, 2022)

Intelligent prediction of coal mine water inrush based on optimized SAPSO-ELM model under the influence of multiple factors - Yong-gang Zhang; Yuan-lun Xie; Li-ning Yang; Rao-ping Liao; Tao Qiu (Arabian Journal of Geosciences, 2022)
Mine water inrush is affected by many factors such as geological structure and fracture zone. However, there may be overlap among these factors, leading to uncertainty, fuzzy similarity and nonlinear relationship among most of them. Therefore, the traditional mathematical model is not ideal to predict water inrush. This paper proposes an intelligent model for predicting water inrush from coal floor based on simulated annealing particle swarm optimization-extreme learning machine (SAPSO-ELM). Based on 144 groups of learning data and 36 groups of predictive validation data, the proposed model extracted common factors from 14 geological factors that might be related to water inrush in a mining area, so as to reduce information interaction among discriminant indexes. In this paper, simulated annealing particle swarm optimization (SAPSO) is innovatively used to optimize the model parameters and compared with other intelligent models (SVM, BPNN, PSO-ELM and ELM) for the learning prediction of the same data. The results show that the common factors extracted from the original variables contain most of the comprehensive information and can reduce information redundancy. Compared with traditional intelligent models (SVM, BPNN, PSO-ELM and ELM), the proposed model improves the computational efficiency of convergence, and the prediction accuracy is higher. It is proved that SAPSO-ELM intelligent algorithm is indeed scientific and has broad application prospect in result prediction induced by complex multi-factors.

Corrigendum: Pigmentibacter ruber gen. nov., sp. nov., a novel bacterium of the family Silvanigrellaceae isolated from human blood - Na Peng; Wen Xu; Hai-Min Luo; Peng-Wen Ouyang; Bin Jiang; Zhi-Hua Zhang; You-De Cao; Li-Ming Tan; Ping-Hua Qu; Liang-Yi Xie (Antonie van Leeuwenhoek, 2022)

Influences of fisheries management measures on biological characteristics of threadfin bream (Nemipterus virgatus) in the Beibu Gulf, South China Sea - Kui Zhang; Ping Geng; Jiajun Li; Youwei Xu; Muhsan Ali Kalhoro; Mingshuai Sun; Dengfu Shi; Zuozhi Chen (Acta Oceanologica Sinica, 2022)

Cancer metabolism and tumor microenvironment: fostering each other? - Yiyuan Yuan; Huimin Li; Wang Pu; Leilei Chen; Dong Guo; Hongfei Jiang; Bo He; Siyuan Qin; Kui Wang; Na Li; Jingwei Feng; Jing Wen; et al. (Science China Life Sciences, 2022)

Plant-derived lignans as potential antiviral agents: a systematic review - Xin-Ya Xu; Dong-Ying Wang; Yi-Ping Li; Stephen T. Deyrup; Hong-Jie Zhang (Phytochemistry Reviews, 2022)

Synthesis and evaluation of ursolic acid-based 1,2,4-triazolo[1,5-a]pyrimidines derivatives as anti-inflammatory agents - Tian-Yi Zhang; Chun-Shi Li; Ping Li; Xue-Qian Bai; Shu-Ying Guo; Ying Jin; Sheng-Jun Piao (Molecular Diversity, 2022)

Mass cultivation of conidia of Pyricularia oryzae - Zhong-na Hao; Hai-ping Qiu; Zhen Zhang; Rong-yao Chai; Shi-zhen Wang; Yan-li Wang; Jiao-yu Wang; Guo-chang Sun (Journal of Plant Pathology, 2022)

Oxidative degradation/mineralization of dimethyl phthalate (DMP) from plastic industrial wastewater using ferrate(VI)/TiO2 under ultraviolet irradiation - Ping Wang; Yi Ding; Liting Zhu; Yunhao Zhang; Sijie Zhou; Linbei Xie; Ao Li (Environmental Science and Pollution Research, 2022)

Comparative Genomic Analysis of Streptococcus pneumoniae Strains: Penicillin Non-susceptible Multi-drug-Resistant Serotype 19A Isolates - Lifeng Li; Juanjuan Zhou; Mingchao Li; Zengyuan Yu; Kaijie Gao; Junwen Yang; Ping Cheng; Junmei Yang; Wancun Zhang; Zhidan Yu; Huiqing Sun (Current Microbiology, 2022)

A Hydroponic Study on Effect of Zinc Against Mercury Uptake by Triticale: Kinetic Process and Accumulation - Ting Liu; Yi Man; Ping Li; Hua Zhang; Huangxin Cheng (Bulletin of Environmental Contamination and Toxicology, 2022)

Aberrant functional and effective connectivity of the frontostriatal network in unilateral acute tinnitus patients with hearing loss - Gang-Ping Zhou; Yu-Chen Chen; Wang-Wei Li; Heng-Le Wei; Yu-Sheng Yu; Qing-Qing Zhou; Xindao Yin; Yue-Jin Tao; Hong Zhang (Brain Imaging and Behavior, 2022)

Correction to: Proteasome-dependent inactivation of Akt is essential for 12-O-tetradecanoylphorbol 13-acetate-induced apoptosis in vascular smooth muscle cells - Yongna Fan; Ping Xie; Hua Zhang; Shubin Guo; Dongfeng Gu; Mingpeng She; HuiHua Li (Apoptosis, 2022)

Oxidation of organoarsenicals and antimonite by a novel flavin monooxygenase widely present in soil bacteria - Jun Zhang; Jian Chen; Yi‐Fei Wu; Zi‐Ping Wang; Ji‐Guo Qiu; Xiao‐Long Li; Feng Cai; Ke‐Qing Xiao; Xiao‐Xu Sun; Barry P. Rosen; Fang‐Jie Zhao (Environmental Microbiology, 2022)
Summary Arsenic can be biomethylated to form a variety of organic arsenicals differing in toxicity and environmental mobility. Trivalent methylarsenite (MAs(III)) produced in the methylation process is more toxic than inorganic arsenite (As(III)). MAs(III) also serves as a primitive antibiotic and, consequently, some environmental microorganisms have evolved mechanisms to detoxify MAs(III). However, the mechanisms of MAs(III) detoxification are not well understood. In this study, we identified an arsenic resistance ( ars ) operon consisting of three genes, arsRVK , that contribute to MAs(III) resistance in Ensifer adhaerens ST2. ArsV is annotated as an NADPH‐dependent flavin monooxygenase with unknown function. Expression of arsV in the arsenic hypersensitive Escherichia coli strain AW3110 Δars conferred resistance to MAs(III) and the ability to oxidize MAs(III) to MAs(V). In the presence of NADPH and either FAD or FMN, purified ArsV protein was able to oxidize both MAs(III) to MAs(V) and Sb(III) to Sb(V). Genes with arsV ‐like sequences are widely present in soils and environmental bacteria. Metagenomic analysis of five paddy soils showed the abundance of arsV ‐like sequences of 0.12–0.25 ppm. These results demonstrate that ArsV is a novel enzyme for the detoxification of MAs(III) and Sb(III) and the genes encoding ArsV are widely present in soil bacteria.

Long-Term Ammonia Toxicity in the Hepatopancreas of Swimming Crab Portunus trituberculatus: Cellular Stress Response and Tissue Damage - Yunliang Lu; Jingyan Zhang; Jianwei Cao; Ping Liu; Jian Li; Xianliang Meng (Frontiers in Marine Science, 2022)
Ammonia is the most common contaminant in aquaculture systems. Due to the unexpected deterioration of natural seawater quality caused by harmful alga blooms in summer, the water exchange cycle for the culture ponds of the swimming crab Portunus trituberculatus , an important aquaculture species in China, is often much longer, and the crabs may be exposed to long-term ammonia stress. However, less information is available regarding the long-term effects of ammonia in marine decapod crustaceans. Therefore, it is of great significance to understand the toxic effects of prolonged ammonia in decapods. In this study, alteration of histology, cellular stress responses (CSRs), and apoptosis in the hepatopancreas of P. trituberculatus , an important aquaculture species, during ammonia stress (5, 15, and 45 mg⋅L –1 ) for 1, 7, and 15 days and recovery at the normal condition for 7 days, were analyzed. Our results demonstrated a serious impact of long-term (15 days) ammonia stress by depressing crab CSR especially when ammonia concentration exceeds 15 mg⋅L –1 . Overall, short- (1 day) and medium-term (7 days) ammonia stress induced CSR, evidenced by upregulated expression of the genes involved in antioxidant defense ( SOD , CAT , and GPX ), apoptosis ( p53 , Bax , and Caspase-3 ), heat shock response (HSR) ( Hsp70 and Hsp90 ), unfolded protein response (UPR) ( IRE1 , ATF6 , and XBP1 ), and DNA damage response (DDR) ( ATR and DNA-PKcs ). However, long-term (15 days) ammonia stress, especially when exposed to the ammonia of 15 and 45 mg⋅L –1 , resulted in a higher level of apoptosis and severe damage of hepatopancreas, which may be related to the depressed CSR including antioxidant defense, HSR, UPR, and DDR. Notably, after recovery, the expressions of many genes involved in apoptosis, antioxidant response, HSR, UPR, and DDR in the groups exposed to ammonia at 15 and 45 mg⋅L –1 were still significantly different to that of the control group. In summary, care should be taken when P. trituberculatus is exposed to ammonia over 15 mg⋅L –1 especially when exposure duration is longer than 15 days, as the CSR could be compromised. This study provides a reference for a comprehensive understanding of CSR in decapod crustaceans under ammonia stress and will be beneficial for management in the intensive culture of the swimming crab.

A community effort to assess and improve computerized interpretation of 12-lead resting electrocardiogram - Zijian Ding; Guijin Wang; Huazhong Yang; Ping Zhang; Dapeng Fu; Zhen Yang; Xinkang Wang; Xia Wang; Zhourui Xia; Chiming Zhang; Wenjie Cai; Binhang Yuan; et al. (Medical & Biological Engineering & Computing, 2022)
Computerized interpretation of electrocardiogram plays an important role in daily cardiovascular healthcare. However, inaccurate interpretations lead to misdiagnoses and delay proper treatments. In this work, we built a high-quality Chinese 12-lead resting electrocardiogram dataset with 15,357 records, and called for a community effort to improve the performances of CIE through the China ECG AI Contest 2019. This dataset covers most types of ECG interpretations, including the normal type, 8 common abnormal types, and the other type which includes both uncommon abnormal and noise signals. Based on the Contest, we systematically assessed and analyzed a set of top-performing methods, most of which are deep neural networks, with both their commonalities and characteristics. This study establishes the benchmarks for computerized interpretation of 12-lead resting electrocardiogram and provides insights for the development of new methods.

Genetic improvement of grain quality traits in indica inbred rice cultivars developed in South China during 1956–2020 - Xin-Qiao Zhou; Da-Gang Chen; Jie Guo; Ping-Li Chen; Li-Jun Li; Ke Chen; You-Ding Chen; Chuan-Guang Liu; Ze-Min Zhang (Euphytica, 2022)

Performance and mechanisms of fly ash for graphene oxide removal from aqueous solution - Ping Jiang; Lin Zhou; Wei Wang; Na Li; Fang Zhang (Environmental Science and Pollution Research, 2022)

Probability risk assessment of soil PAH contamination premised on industrial brownfield development: a case from China - Wei Tian; Ping Guo; Huimin Li; Guangmin Zhang (Environmental Science and Pollution Research, 2022)

Subproteomic profiling from renal cortices in OLETF rats reveals mutations of multiple novel genes in diabetic nephropathy - Zhiguo Li; Hong Shen; Yeqiang Liu; Xuefeng Zhou; Meihua Yan; Hailan He; Tingting Zhao; Haojun Zhang; Ping Li (Genes & Genomics, 2022)

Complete genome analysis of a nege-like virus in aphids (Astegopteryx formosana) - Xiao-Di Zhang; Gang Lu; Zhuang-Xin Ye; Jian-Ping Chen; Chuan-Xi Zhang; Jun-Min Li (Archives of Virology, 2022)

A novel alphapartitivirus from binucleate Rhizoctonia fumigata AG-Ba isolate C-314 Baishi - Yanqiong Li; Yang Sun; Ping Xu; Lifang Zhang; Zebin Chen; Yanfen Niu; Genhua Yang; Xiaohan Mo (Archives of Virology, 2022)

Biogeography of culturable marine bacteria from both poles reveals that ‘everything is not everywhere’ at the genomic level - Qi‐Long Qin; Zhi‐Bin Wang; Qian‐Qian Cha; Sha‐Sha Liu; Xue‐Bing Ren; Hui‐Hui Fu; Mei‐Ling Sun; Dian‐Li Zhao; Andrew McMinn; Yin Chen; Xiu‐Lan Chen; Yu‐Zhong Zhang; et al. (Environmental Microbiology, 2022)
Summary Based on 16S rRNA gene analyses, the same bacterial operational taxonomic units (OTUs) are common to both the Arctic and Antarctic oceans, supporting the concept ‘everything is everywhere’. However, whether the same OTUs from both poles have identical genomes, i.e. whether ‘everything is still everywhere’ at the genomic level has not yet been examined systematically. Here, we isolated, sequenced and compared the genomes of 45 culturable marine bacteria belonging to three genera of Salinibacterium , Psychrobacter and Pseudoalteromonas from both polar oceans. The bacterial strains with identical 16S rRNA genes were common to both poles in every genus, and four identical genomes were detected in the genus Salinibacterium from the Arctic region. However, no identical genomes were observed from opposite poles in this study. Our data, therefore, suggest that ‘everything is not everywhere’ at the genomic level. The divergence time between bacteria is hypothesized to exert a strong impact on the bacterial biogeography at the genomic level. The geographical isolation between poles was observed for recently diverged, highly similar genomes, but not for moderately similar genomes. This study thus improves our understanding of the factors affecting the genomic‐level biogeography of marine microorganisms isolated from distant locations.

Physiological and Molecular Responses in the Gill of the Swimming Crab Portunus trituberculatus During Long-Term Ammonia Stress - Jingyan Zhang; Mengqian Zhang; Nishad Jayasundara; Xianyun Ren; Baoquan Gao; Ping Liu; Jian Li; Xianliang Meng (Frontiers in Marine Science, 2021)
Ammonia is a common environmental stressor encountered during aquaculture, and is a significant concern due to its adverse biological effects on vertebrate and invertebrate including crustaceans. However, little information is available on physiological and molecular responses in crustaceans under long-term ammonia exposure, which often occurs in aquaculture practices. Here, we investigated temporal physiological and molecular responses in the gills, the main ammonia excretion organ, of the swimming crab Portunus trituberculatus following long-term (4 weeks) exposure to three different ammonia nitrogen concentrations (2, 4, and 8 mg l –1 ), in comparison to seawater (ammonia nitrogen below 0.03 mg l –1 ). The results revealed that after ammonia stress, the ammonia excretion and detoxification pathways were initially up-regulated. These processes appear compromised as the exposure duration extended, leading to accumulation of hemolymph ammonia, which coincided with the reduction of adenosine 5′-triphosphate (ATP) and adenylate energy charge (AEC). Considering that ammonia excretion and detoxification are highly energy-consuming, the depression of these pathways are, at least partly, associated with disruption of energy homeostasis in gills after prolonged ammonia exposure. Furthermore, our results indicated that long-term ammonia exposure can impair the antioxidant defense and result in increased lipid peroxidation, as well as induce endoplasmic reticulum stress, which in turn lead to apoptosis through p53-bax pathway in gills of the swimming crab. The findings of the present study further our understanding of adverse effects and underlying mechanisms of long-term ammonia in decapods, and provide valuable information for aquaculture management of P. trituberculatus .

Discriminative optimization algorithm with global–local feature for LIDAR point cloud registration - Jia Wang; Ping Wang; Biao Li; Ruigang Fu; Siyi Zhao; Hong Zhang (International Journal of Remote Sensing, 2021)

Identification of New Transcription Factors that Can Promote Pluripotent Reprogramming - Ping Huang; Jieying Zhu; Yu Liu; Guihuan Liu; Ran Zhang; Dongwei Li; Duanqing Pei; Ping Zhu (Stem Cell Reviews and Reports, 2021)
Background Four transcription factors, Oct4, Sox2, Klf4, and c-Myc (the Yamanka factors), can reprogram somatic cells to induced pluripotent stem cells (iPSCs). Many studies have provided a number of alternative combinations to the non-Yamanaka factors. However, it is clear that many additional transcription factors that can generate iPSCs remain to be discovered. Methods The chromatin accessibility and transcriptional level of human embryonic stem cells and human urine cells were compared by Assay for Transposase-Accessible Chromatin with high-throughput sequencing (ATAC-seq) and RNA sequencing (RNA-seq) to identify potential reprogramming factors. Selected transcription factors were employed to reprogram urine cells, and the reprogramming efficiency was measured. Urine-derived iPSCs were detected for pluripotency by Immunofluorescence, quantitative polymerase chain reaction, RNA sequencing and teratoma formation test. Finally, we assessed the differentiation potential of the new iPSCs to cardiomyocytes in vitro. Results ATAC-seq and RNA-seq datasets predicted TEAD2, TEAD4 and ZIC3 as potential factors involved in urine cell reprogramming. Transfection of TEAD2, TEAD4 and ZIC3 (in the presence of Yamanaka factors) significantly improved the reprogramming efficiency of urine cells. We confirmed that the newly generated iPSCs possessed pluripotency characteristics similar to normal H1 embryonic stem cells. We also confirmed that the new iPSCs could differentiate to functional cardiomyocytes. Conclusions In conclusion, TEAD2, TEAD4 and ZIC3 can increase the efficiency of reprogramming human urine cells into iPSCs, and provides a new stem cell sources for the clinical application and modeling of cardiovascular disease. Graphical abstract

Bacterial Community Structure and Diversity in the Aqueous Environment of Shihou Lake and its Relationship with Environmental Factors - Ru Deng; Xi Chen; Li-Ping Qiu; Jia-Zhang Chen; Shun-Long Meng (Indian Journal of Microbiology, 2021)

Correction to: Enhanced adsorption of phosphorus in soil by lanthanum-modified biochar: improving phosphorus retention and storage capacity - Di Zhao; Yuan Luo; Yi-yang Feng; Qiu-ping He; Li-sheng Zhang; Ke-qiang Zhang; Feng Wang (Environmental Science and Pollution Research, 2021)

Enhanced adsorption of phosphorus in soil by lanthanum-modified biochar: improving phosphorus retention and storage capacity - Di Zhao; Yuan Luo; Yi-yang Feng; Qiu-ping He; Li-sheng Zhang; Ke-qiang Zhang; Feng Wang (Environmental Science and Pollution Research, 2021)

Astaxanthin Ameliorates Blood Pressure in Salt-Induced Prehypertensive Rats Through ROS/MAPK/NF-κB Pathways in the Hypothalamic Paraventricular Nucleus - Hong-Li Gao; Xiao-Jing Yu; Yan Zhang; Chen-Long Wang; Yi-Ming Lei; Jia-Yue Yu; Dong-Miao Zong; Kai-Li Liu; Dong-Dong Zhang; Ying Li; Hua Tian; Nian-Ping Zhang; et al. (Cardiovascular Toxicology, 2021)

SIRT3-mediated mitochondrial unfolded protein response weakens breast cancer sensitivity to cisplatin - Hao Chen; Dong-Ming Zhang; Zhi-Ping Zhang; Ming-Zhang Li; Hai-Feng Wu (Genes & Genomics, 2021)

Triaxial mechanical properties and micro mechanism of fiber-modified cement soil - Yang Yao; Na Li; Haibo Kang; Wenjie Yu; Chen Zhang; Ping Jiang; Wei Wang (Arabian Journal of Geosciences, 2021)

Optimization method of first-arrival waveform inversion based on the L-BFGS algorithm - Zhang Kai; Xu Xin; Liu Hong-Xing; Xu Yi-Peng; Li Zhen-Chun; Jiang Ping (Applied Geophysics, 2021)

Stress response mechanisms and description of three novel species Shewanella avicenniae sp. nov., Shewanella sedimentimangrovi sp. nov. and Shewanella yunxiaonensis sp. nov., isolated from mangrove ecosystem - Guo-Hong Liu; Qi Zhang; Manik Prabhu Narsing Rao; Shang Yang; Rong Tang; Huai Shi; Jie-Ping Wang; Guan-Min Huang; Bo Liu; Shun-Gui Zhou; Wen-Jun Li (Antonie van Leeuwenhoek, 2021)

The Innate Immune Response to Infection by Polyascus gregaria in the Male Chinese Mitten Crab (Eriocheir sinensis), Revealed by Proteomic Analysis - Yanping Yang; Fengjiao Ma; Juanjuan Dong; Lianxing Li; Ping Ren; Yuning Zhang; Yatao Wu; Yinping Wang; Kai Liu; Fang Zhang (Fishes, 2021)
The Chinese mitten crab (Eriocheir sinensis) is a representative catadromous invertebrate of the Yangtze River and a commercial species widely cultivated in China. Both cultivated and wild crabs suffer from a variety of parasites and pathogens, which can result in catastrophic economic losses in aquaculture revenue. Polyascus gregaria, a parasitic barnacle with a highly derived morphology, is specialized in invading these crabs. This study examines the immunological mechanism in E. sinensis infected with P. gregaria. Tandem mass tags (TMT), a specialized method of mass-spectrometry, was used to analyze the infection by P. gregaria resistance at the protein level. In the hepatopancreas of infected crabs, 598 proteins differentially expressed relating to physiological change, of which, 352 were upregulated and 246 were downregulated. Based on this differential protein expression, 104 GO terms and 13 KEGG pathways were significantly enriched. Differentially expressed proteins, such as ATG, cathepsin, serpin, iron-related protein, Rab family, integrin, and lectin, are associated with the lysosome GO term and the autophagy-animal KEGG pathways, both of which likely relate to the immune response to the parasitic P. gregaria infection. These results show the benefit of taking a detailed, protein-level approach to understanding the innate immune response of aquatic invertebrates to macroparasite infection.

Genetic Prion Disease: Insight from the Features and Experience of China National Surveillance for Creutzfeldt-Jakob Disease - Qi Shi; Cao Chen; Kang Xiao; Wei Zhou; Li-Ping Gao; Dong-Dong Chen; Yue-Zhang Wu; Yuan Wang; Chao Hu; Chen Gao; Xiao-Ping Dong (Neuroscience Bulletin, 2021)

Geo-structures and deformation-failure characteristics of rockslide areas near the Baige landslide scar in the Jinsha River tectonic suture zone - Shi-lin Zhang; Yue-ping Yin; Xie-wen Hu; Wen-pei Wang; Zong-liang Li; Xin-ming Wu; Gang Luo; Sai-nan Zhu (Landslides, 2021)

Differences in pathogenicity and physiologic races between Pyricularia oryzae isolates from indica and japonica rice varieties - Zhong-na Hao; Zhen Zhang; Hai-ping Qiu; Rong-yao Chai; Shi-zhen Wang; Yan-li Wang; Jiao-yu Wang; Guo-chang Sun (Journal of Plant Pathology, 2021)

Effects of Low‐dose Mercury Exposure in Newborns on mRNA Expression Profiles - Haohao Liu; Chanchan Zhang; Fuli Wen; Lin Feng; Huiqun Wang; Wenjuan Wang; Ping Li (Bulletin of Environmental Contamination and Toxicology, 2021)

Qaidamihabitans albus gen. nov., sp. nov., a new member of the family Pseudonocardiaceae, and transfer of Prauserella shujinwangii to Qaidamihabitans gen. nov. as Qaidamihabitans shujinwangii comb. nov. - Li-Sha Tian; Gang-Qiang Jiang; Rui Li; Ping Ni; Chuan-En Li; Hong-Yan Zhang; Juan Wang; Xiao-Ping Zhang; Yun Wang; Shu-Kun Tang (Archives of Microbiology, 2021)

Dynamic evolution of eukaryotic mitochondrial and nuclear genomes: a case study in the gourmet pine mushroom Tricholoma matsutake - Shu Zhang; Xue Bai; Li‐Yuan Ren; Hui‐Hui Sun; Hui‐Ping Tang; Lu‐Min Vaario; Jianping Xu; Yong‐Jie Zhang (Environmental Microbiology, 2021)
Summary Fungi, as eukaryotic organisms, contain two genomes, the mitochondrial genome and the nuclear genome, in their cells. How the two genomes evolve and correlate to each other is debated. Herein, taking the gourmet pine mushroom Tricholoma matsutake as an example, we performed comparative mitogenomic analysis using samples collected from diverse locations and compared the evolution of the two genomes. The T. matsutake mitogenome encodes 49 genes and is rich of repetitive and non‐coding DNAs. Six genes were invaded by up to 11 group I introns, with one cox1 intron cox1P372 showing presence/absence dynamics among different samples. Bioinformatic analyses suggested limited or no evidence of mitochondrial heteroplasmy. Interestingly, hundreds of mitochondrial DNA fragments were found in the nuclear genome, with several larger than 500 nt confirmed by PCR assays and read count comparisons, indicating clear evidence of transfer of mitochondrial DNA into the nuclear genome. Nuclear DNA of T. matsutake showed a higher mutation rate than mitochondrial DNA. Furthermore, we found evidence of incongruence between phylogenetic trees derived from mitogenome and nuclear DNA sequences. Together, our results reveal the dynamic genome evolution of the gourmet pine mushroom.

Induced production of a new polyketide in Penicillium sp. HS-11 by chemical epigenetic manipulation - You-Min Ying; Ling Li; Hang-Fei Yu; Yi-Lian Xu; Lu Huang; Wei Mao; Cui-Ping Tong; Zhi-Dong Zhang; Zha-Jun Zhan; Yun Zhang (Natural Product Research, 2021)

Pleosporalins H and I, two new heptaketides from the endophytic fungus Pleosporales sp. F46 by using OSMAC strategy - Hong-Xia Yang; Xiao-Ping Peng; Han Gao; Hui-Min Zhang; Zi-Ru Wang; Gang Li; Hong-Xiang Lou (Natural Product Research, 2021)

Functional analysis of indole 3-hexanoic acid as a novel auxin from Arabidopsis thaliana - Ping Song; Hui Xu; Jixiu Zhang; Huatao Chen; Li Li; Yana Qu; Feng Lin; Qun Zhang (Planta, 2021)

Responses of leaf litter decomposability to nitrogen and phosphorus additions are associated with cell wall carbohydrate composition in a subtropical plantation - Xiang-Min Fang; Xiu-Lan Zhang; Ying-Ying Zong; Wen-Qing Li; Jian-Jun Li; Li-Ping Guo; Huimin Wang; Fu-Sheng Chen (Plant and Soil, 2021)

MiR-590-5p inhibits pathological hypertrophy mediated heart failure by targeting RTN4 - Ping Fan; Likun Zhang; Tianyu Cheng; Jing Wang; Junyun Zhou; Li Zhao; Cuie Hua; Quan Xia (Journal of Molecular Histology, 2021)

Globular adiponectin inhibits osteoblastic differentiation of vascular smooth muscle cells through the PI3K/AKT and Wnt/β-catenin pathway - Yun Zhou; Li-Long Wei; Rui-Ping Zhang; Cheng-Wu Han; Yongtong Cao (Journal of Molecular Histology, 2021)
Lipid metabolism is closely related to the improvement of vascular calcification (VC) in chronic kidney disease (CKD). Globular adiponectin (gAd) has been reported to be involved in the development of VC in CKD, but the detailed regulatory role remains unclear. The present study is aimed to investigate the biological function and the underlying regulation mechanism of gAd in the process of VC during CKD. Vascular smooth muscle cells (VSMCs) calcification was determined by Alizarin Red S staining. Protein signaling related with VC was tested by western blotting. The expression and intracellular localization of runt-related transcription factor 2 (Runx2) was detected by immunofluorescence and uraemic rat with VC was established by a two-step nephrectomy. Combined with the results of Alizarin Red S staining, we discovered that β-glycerophosphate (β-Gp)-induced the osteoblastic differentiation of VSMCs was significantly reversed by gAd treatment. Along with the VSMCs calcification and the increase of Runx2 in β-Gp-exposed VSMCs, the activities of protein kinase B (AKT) and Wnt/β-catenin pathway were enhanced, but that were counteracted by the exposure of gAd in rat and human VSMCs. After administration with agonists of the Wnt (SKL2001) and AKT (SC79), there appeared more osteoblastic differentiation and higher expression of Runx2 in gAd-treated VSMCs, but showing lower impact in the presence of SC79 than that in the presence of SKL2001. In the in vivo experiments, intravenous injection of gAd also significantly inhibited VC and Runx2 level in uraemic rat in a dose-dependent manner, possibly through regulating Wnt/β-catenin pathway. This study demonstrates that gAd ameliorates osteoblastic differentiation of VSMCs possibly by blocking PI3K/AKT and Wnt/β-catenin signaling transduction. The findings provide an important foundation for gAd in treating VC in kidney diseases.

Resource utilization of organic spent adsorbent to prepare three-dimensional sulfate-functionalized layered double oxide for superior removal of azo dye - Lingjie Zhang; Siyin Zheng; Peng Li; Zhongbang Zhu; Youqin Zou; Ping Zhang (Environmental Science and Pollution Research, 2021)

Aberrant activity within auditory network is associated with psychiatric comorbidities in interictal migraineurs without aura - Heng-Le Wei; Yu-Chen Chen; Yu-Sheng Yu; Xi Guo; Gang-Ping Zhou; Qing-Qing Zhou; Li-Jie Qu; Xindao Yin; Junrong Li; Hong Zhang (Brain Imaging and Behavior, 2021)

Stable isotopes (δ2H) in feathers identify non-breeding origins of the endangered Jankowski’s Bunting - Zheng Han; Hai-Tao Wang; Kevin J. Kardynal; Keith A. Hobson; Wei-Ping Shang; li-shi Zhang; Yun-lei Jiang; Frédéric Jiguet (Journal of Ornithology, 2021)

Serum levels of polychlorinated biphenyls and stroke risk among Chinese: a hospital-based case–control study - Ping Li; Ying Dan; Shuangying Li; Qiaolian Zhang; Ya Su; Mei Lu (Acta Neurologica Belgica, 2021)

Characterization of a novel shrimp pathogen, Vibrio brasiliensis , isolated from Pacific white shrimp, Penaeus vannamei - Ge Li; Guosi Xie; Hailiang Wang; Xiaoyuan Wan; Xinshu Li; Chengyin Shi; Ziyan Wang; Miao Gong; Ting Li; Ping Wang; Qingli Zhang; Jie Huang (Journal of Fish Diseases, 2021)
A novel pathogenic strain Vibrio 20190611023 was isolated from the hepatopancreas of moribund cultured Penaeus vannamei suffering from black gill disease. This strain was identified as V . brasiliensis based on the phylogenetic analyses of 16S rDNA gene and five other housekeeping genes (i.e., gapA , ftsZ , mreB , topA and gyrB ). Some biochemical features of this strain were determined with an API 20NE system, and its haemolytic activity was determined using a sheep blood agar plate. The pathogenicity of this isolate 20190611023 was confirmed by the experimental challenge tests and histopathological examinations. P. vannamei were challenged via reverse gavage with different doses of bacterial suspensions. The calculated median lethal dose (LD 50 ) was (3.16 ± 1.78) × 10 5 CFU/g (body weight). Moreover, antibiotic susceptibility tests were performed, the results of which showed that the strain 20190611023 was sensitive to chloramphenicol, compound sulphamethoxazole, ciprofloxacin, doxycycline and oxacillin, but resistant to erythromycin, kanamycin, gentamicin, cefoperazone, ceftriaxone, cefamezin and piperacillin. To our knowledge, this is the first report for demonstrating V . brasiliensis as a shrimp pathogen, which expands the host range of V . brasiliensis infection. The present study highlights that more attention should be paid to this novel pathogen in intensive shrimp aquaculture.

On the origin of SARS-CoV-2—The blind watchmaker argument - Chung-I Wu; Haijun Wen; Jian Lu; Xiao-dong Su; Alice C. Hughes; Weiwei Zhai; Chen Chen; Hua Chen; Mingkun Li; Shuhui Song; Zhaohui Qian; Qihui Wang; et al. (Science China Life Sciences, 2021)

Problem-solving deficits in methcathinone use disorder - Hang-Bin Zhang; Di Zhao; Yu-Ping Liu; Li-Xun Wang; Bo Yang; Ti-Fei Yuan (Psychopharmacology, 2021)

Hygrophorus russula complex (Hygrophoraceae, Agaricales) in China - Hong-Yan Huang; Wen-Hao Zhang; Ting Huang; Moreno Gabriel; Tie-Zhi Liu; Li-Ping Tang (Mycological Progress, 2021)

Migration and transformation of heavy metals in hyperaccumulators during the thermal treatment: a review - Wei Su; Xinyan Li; Hongshuo Zhang; Yi Xing; Ping Liu; Changqing Cai (Environmental Science and Pollution Research, 2021)

A comparative study of peroxydisulfate and peroxymonosulfate activation by a transition metal–H2O2 system - Yanli Zhu; Yuan Liu; Ping Li; Yue Zhang; Gang Wang; Youxian Zhang (Environmental Science and Pollution Research, 2021)

Methane Concentration in the Heartwood of Living Trees and Estimated Methane Emission on Stems in Upland Forests - Zhi-Ping Wang; Huan-Long Li; Hong-Hui Wu; Shi-Jie Han; Jian-Hui Huang; Xi-Mei Zhang; Xing-Guo Han (Ecosystems, 2021)

An experimental study on cutting tool hardness optimization for shield TBMs during dense fine silty sand ground tunneling - Xiao-Ping Zhang; Shao-Hui Tang; Quan-Sheng Liu; Xin-Bin Tu; Peng Chen; Fang-Yi Li (Bulletin of Engineering Geology and the Environment, 2021)

Taxonomic description of Pseudomonas rhizovicinus sp. nov., isolated from the rhizosphere of a desert shrub Haloxylon ammodendron - Ao-Lei He; Hui-Ru Li; Hui-Ping Li; Jing-Yi Gou; Jia Chen; Qi Zhao; Jin-Lin Zhang (Antonie van Leeuwenhoek, 2021)

Triterpene saponins from tea seed pomace ( Camellia oleifera Abel) and their cytotoxic activity on MCF-7 cells in vitro - Xin-Fu Zhang; Ying-Ying Han; Tai-Mei Di; Li-Ping Gao; Tao Xia (Natural Product Research, 2021)

Sodium cantharidinate, a novel anti-pancreatic cancer agent that activates functional p53 - Xiaoxiao Liu; Li Zhang; Pyone Myat Thu; Wenjian Min; Peng Yang; Ji Li; Ping Li; Xiaojun Xu (Science China Life Sciences, 2021)

Two new species of Amanita section Roanokenses with a radicating basal bulb - Juan Zhong; Gui-Wu Li; Jin-Bao Pu; Zuo-Hong Chen; Ping Zhang (Mycological Progress, 2021)

Genetic diversity of potato virus Y potato isolates from Shandong province, China - Meng-Ao Jia; Lu Wang; Ji-Wu Zhang; Yu-Shuang Guo; Xiang-Dong Li; Yan-Ping Tian (Journal of Plant Pathology, 2021)

Farnesoic acid methyltransferase 6 (BmFAMeT6) interrelates with moltinism of dominant trimolter in silkworm, Bombyx mori - Liang Zhang; Xiuzhi Li; Tian Li; Rong Xiong; Yan Li; Dongsheng Yan; Ping Chen (Biologia, 2021)

The rescue and selection of thermally stable type O vaccine candidate strains of foot-and-mouth disease virus - Ya Gao; Pinghua Li; Xueqing Ma; Xingwen Bai; Pu Sun; Ping Du; Hong Yuan; Yimei Cao; Kun Li; Yuanfang Fu; Jing Zhang; Huifang Bao; et al. (Archives of Virology, 2021)

Assessment of the rock slope stability of Fushun West Open-pit Mine - Fei Zhang; Tianhong Yang; Lianchong Li; Jianqing Bu; Tianliang Wang; Ping Xiao (Arabian Journal of Geosciences, 2021)

Genetic mapping of highly versatile and solvent‐tolerant Pseudomonas putida B6 ‐2 ( ATCC BAA ‐2545) as a ‘superstar’ for mineralization of PAHs and dioxin‐like compounds - Weiwei Wang; Qinggang Li; Lige Zhang; Jie Cui; Hao Yu; Xiaoyu Wang; Xingyu Ouyang; Fei Tao; Ping Xu; Hongzhi Tang (Environmental Microbiology, 2021)
Summary Polycyclic aromatic hydrocarbons (PAHs) and dioxin‐like compounds, including sulfur, nitrogen and oxygen heterocycles, are widespread and toxic environmental pollutants. A wide variety of microorganisms capable of growing with aromatic polycyclic compounds are essential for bioremediation of the contaminated sites and the Earth's carbon cycle. Here, cells of Pseudomonas putida B6‐2 (ATCC BAA‐2545) grown in the presence of biphenyl (BP) are able to simultaneously degrade PAHs and their derivatives, even when they are present as mixtures, and tolerate high concentrations of extremely toxic solvents. Genetic analysis of the 6.37 Mb genome of strain B6‐2 reveals coexistence of gene clusters responsible for central catabolic systems of aromatic compounds and for solvent tolerance. We used functional transcriptomics and proteomics to identify the candidate genes associated with catabolism of BP and a mixture of BP, dibenzofuran, dibenzothiophene and carbazole. Moreover, we observed dynamic changes in transcriptional levels with BP, including in metabolic pathways of aromatic compounds, chemotaxis, efflux pumps and transporters potentially involved in adaptation to PAHs. This study on the highly versatile activities of strain B6‐2 suggests it to be a potentially useful model for bioremediation of polluted sites and for investigation of biochemical, genetic and evolutionary aspects of Pseudomonas .

A new ent -kaurane diterpene from Isodon henryi - Xue Jiang; Ling-Xia Zhang; Qing-Mei Feng; Hong Wu; Ya-Lin Liu; De-Qin Wang; Li-Ping Dai; Zhi-Min Wang (Natural Product Research, 2021)

Comparative analysis of sRNAs, degradome and transcriptomics in sweet sorghum reveals the regulatory roles of miRNAs in Cd accumulation and tolerance - Weitao Jia; Kangqi Lin; Tengxue Lou; Juanjuan Feng; Sulian Lv; Ping Jiang; Ze Yi; Xuan Zhang; Duoliya Wang; Zijing Guo; Yetao Tang; Rongliang Qiu; et al. (Planta, 2021)

Citrus NIP5;1 aquaporin regulates cell membrane water permeability and alters PIPs plasma membrane localization - Mingfei Zhang; Ruilian Liu; Hai Liu; Hongbin Yang; Xin Li; Ping Wang; Feng Zhu; Rangwei Xu; Shaowu Xue; Yunjiang Cheng (Plant Molecular Biology, 2021)

Genetic Analysis of ZNF Protein Family Members for Early-Onset Parkinson’s Disease in Chinese Population - Chun Yu Li; Ru Wei Ou; Yong Ping Chen; Xiao Jing Gu; Qian Qian Wei; Bei Cao; Ling Yu Zhang; Yan Bing Hou; Kun Cheng Liu; Xue Ping Chen; Wei Song; Bi Zhao; et al. (Molecular Neurobiology, 2021)

HDAC3 Downregulation Improves Cerebral Ischemic Injury via Regulation of the SDC1-Dependent JAK1/STAT3 Signaling Pathway Through miR-19a Upregulation - Hua Fang; Hua-Feng Li; Ming-Hai He; Miao Yang; Jian-Ping Zhang (Molecular Neurobiology, 2021)

Characteristics of RNA alternative splicing and its potential roles in ginsenoside biosynthesis in a single plant of ginseng, Panax ginseng C.A. Meyer - Yilai Han; Lei Zhu; Li Li; Yanfang Wang; Mingzhu Zhao; Kangyu Wang; Chunyu Sun; Jing Chen; Lingyu Liu; Ping Chen; Jun Lei; Yi Wang; et al. (Molecular Genetics and Genomics, 2021)

Design, synthesis, and antidepressant/anticonvulsant activities of 3H-benzo[f]chromen chalcone derivatives - Qiu-Wan Tan; Li-Ya He; Zhi-Wen He; Wei-Hua Liu; Shan-Shan Zhang; Lin Lin; Hong-Li Yang; Li-Ping Guan (Medicinal Chemistry Research, 2021)

First report of Bacillus altitudinis causing seed rot of pomegranate in China - Qili Liu; Dongxiao Li; Haiyan Hu; Qianqian Huang; Yongheng Zhang; Feng Zhou; Puwen Song; Yuanyuan Guan; Ruifang Bu; Ping Hu; Jianjun Hao; Chengwei Li (Australasian Plant Pathology, 2021)

Neuroprotective carbazole alkaloids from the stems and leaves of Clausena lenis - Gui Yan; Yu-Jie Li; Ying-Ying Zhao; Jia-Ming Guo; Wen-Hao Zhang; Ming-Ming Zhang; Yan-Hui Fu; Yan-Ping Liu (Natural Product Research, 2021)

Steroidal glycosides from the underground parts of Hosta ventricosa and their anti-inflammatory activities in mice - Hong-Biao Chu; Nan-Nan Li; Zong-Ping Zhang; Xiao-Yue Hu; Cai-Yun Yu; Lei Hua (Natural Product Research, 2021)

3D DEM analysis on tractive trafficability of a lunar rover wheel with bionic wheel lugs - Hao Pang; Rui Zhang; Ping Ge; Fang Liu; Chengjin Wang; Wenchao Dong; Tao Li; Jianqiao Li (Rendiconti Lincei. Scienze Fisiche e Naturali, 2021)

Ziziphus jujuba Mill., a plant used as medicinal food: a review of its phytochemistry, pharmacology, quality control and future research - Shi-Jun Liu; Yan-Ping Lv; Zhi-Shu Tang; Yu Zhang; Hong-Bo Xu; Dong-Bo Zhang; Chun-Li Cui; Hong-Bo Liu; Huan-Huan Sun; Zhong-Xing Song; Si-Min Wei (Phytochemistry Reviews, 2021)

Using the Metabolome to Understand the Mechanisms Linking Chronic Arsenic Exposure to Microglia Activation, and Learning and Memory Impairment - Rui-Yuan Zhang; Jie-Bai Tu; Rui-Tu Ran; Wen-Xuan Zhang; Qiang Tan; Ping Tang; Tao Kuang; Shu-Qun Cheng; Cheng-Zhi Chen; Xue-Jun Jiang; Chang Chen; Ting-Li Han; et al. (Neurotoxicity Research, 2021)

Research on displacement prediction of step-type landslide under the influence of various environmental factors based on intelligent WCA-ELM in the Three Gorges Reservoir area - Yong-gang Zhang; Xin-quan Chen; Rao-ping Liao; Jun-li Wan; Zheng-ying He; Zi-xin Zhao; Yan Zhang; Zheng-yang Su (Natural Hazards, 2021)

Cross-frequency and iso-frequency estimation of functional corticomuscular coupling after stroke - Ping Xie; Xiaohui Pang; Shengcui Cheng; Yuanyuan Zhang; Yinan Yang; Xiaoli Li; Xiaoling Chen (Cognitive Neurodynamics, 2021)

Detecting freeze–thaw damage degradation of sandstone with initial damage using NMR technology - Taoying Liu; Chaoyang Zhang; Jiangteng Li; Keping Zhou; Cao Ping (Bulletin of Engineering Geology and the Environment, 2021)

LAI scale effect research based on compact airborne spectrographic imager data in the Heihe Oasis - Xiao-ai Dai; Chao Liu; Nai-wen Li; Mei-lian Wang; Yu-wei Yang; Xing-ping Yang; Shi-qi Zhang; Xu-wei He; Zheng-li Yang; Heng Lu; Jing-zhong Li; Ze-kun Wang (Journal of Mountain Science, 2021)

Nutrigenomics reveals potential genetic underpinning of diverse taste preference of Chinese men - Zhouhai Zhu; Junpu Mei; Silong Sun; Sheming Lu; Meng Li; Ying Guan; Ying Chen; Yuqiong Xu; Tao Zhang; Fengxue Shi; Xuemei Li; Mingming Miao; et al. (Genes & Genomics, 2021)

Pigmentibacter ruber gen. nov., sp. nov., a novel bacterium of the family Silvanigrellaceae isolated from human blood - Na Peng; Wen Xu; Hai-Min Luo; Peng-Wen Ouyang; Bin Jiang; Zhi-Hua Zhang; You-De Cao; Li-Ming Tan; Ping-Hua Qu; Liang-Yi Xie (Antonie van Leeuwenhoek, 2021)

Study on Microwave Heating Order and Electromagnetic Characteristics of Copper and Gold Ores - Feng Lin; Xia-Ting Feng; Gao-Ming Lu; Xiang-Xin Su; Shi-Ping Li; Jiu-yu Zhang (Rock Mechanics and Rock Engineering, 2021)

Antifungal Effect of Long Noncoding RNA 9708-1 in the Vulvovaginal Candidiasis Murine Model - Ying Wu; Lisha Jiang; Lingling Zhang; Xia Liu; Lina Yan; Ting Luan; Can Rui; Zhiyuan Mao; Chong Fan; Yu Liu; Ping Li; Xin Zeng (Mycopathologia, 2021)
Vulvovaginal candidiasis (VVC) caused by Candida spp. affects 70–75% of women at least once during their lives. We aim to elucidate the potential mechanism of VVC and investigate the therapeutic effects of long noncoding RNA 9708-1. Female BALB/c mice were randomized to four treatment groups, including the blank control group, VVC control group, vehicle control group and lncRNA 9708-1-overexpressed group. Mice were euthanized on Day 4, Day 7 and Day 14 after treatment. Colony-forming unit (CFU) was measured, and the inflammation was detected by hematoxylin and eosin (H&E). Gene and protein expression levels of lncRNA 9708-1 and FAK were determined by real-time PCR, Western blot and immunohistochemistry. The overexpression of lncRNA 9708-1 significantly decreased the fungal load from Day 4 to 7. H&E staining indicated that the impaired histological profiles were improved in lncRNA 9708-1-overexpressed group. LncRNA 9708-1 led to a significant increase in FAK level of vagina tissue which is expressed mainly in epithelial basal layer. This study suggests that lncRNA 9708-1 played a protective role on murine experimental VVC by upregulating the expression levels of FAK.

Correction to: Exploring the Genetic Association of the ABAT Gene with Alzheimer’s Disease - Quanzhen Zheng; Rui Bi; Min Xu; Deng-Feng Zhang; Li-Wen Tan; Ya-Ping Lu; Yong-Gang Yao (Molecular Neurobiology, 2021)

Exploring the Genetic Association of the ABAT Gene with Alzheimer’s Disease - Quanzhen Zheng; Rui Bi; Min Xu; Deng-Feng Zhang; Li-Wen Tan; Ya-Ping Lu; Yong-Gang Yao (Molecular Neurobiology, 2021)

Bjerkandera adusta M1 inhibits the growth of Fusarium oxysporum f. sp. conglutinans and fusarium wilt incidence in Brassica napus L. - Xiao Feng; Su-Ping Li; Yi-Fan Lu; Jing-Jie Zhang; Yun-Yun Zhu; Yong Li; Hong-Jun Yang; Xin-Hua He (Journal of Plant Pathology, 2021)

Contaminated site–induced health risk using Monte Carlo simulation: evaluation from the brownfield in Beijing, China - Ping Guo; Huimin Li; Guangmin Zhang; Wei Tian (Environmental Science and Pollution Research, 2021)

Exposed to Mercury-Induced Oxidative Stress, Changes of Intestinal Microflora, and Association between them in Mice - Yulan Zhao; Changming Zhou; Xiaoquan Guo; Guoliang Hu; Guyue Li; Yu Zhuang; Huabin Cao; Lin Li; Chonghong Xing; Caiying Zhang; Fan Yang; Ping Liu (Biological Trace Element Research, 2021)

Lithological and environmental controls on large tafoni along conglomerate cliffs in subtropic humid Danxiashan UNESCO Global Geopark - Xin Chen; Liu-qin Chen; Yan-hong Zhang; Ding-ding Du; Hai-ping Hu; Dong-xing Liu; Wen-zhuo Li (Journal of Mountain Science, 2021)

Emergent chikungunya fever and vertical transmission in Yunnan Province, China, 2019 - XiaoXiong Yin; Ting-Song Hu; HaiLin Zhang; YongHua Liu; ZhiJian Zhou; LeBin Liu; Ping Li; YiYin Wang; ZhaoLan Yang; Jing Yu; SiYu Chen; Fu-Qiang Zhang (Archives of Virology, 2021)

Effect of fermentation bed on bacterial growth in the fermentation mattress material and cecum of ducks - Jian- mei Wang; Xin- meng Gan; Fa-jun Pu; Wan- xia Wang; Min Ma; Ling-li Sun; Ji-wei Hu; Bo Hu; Rong-ping Zhang; Li-li Bai; Liang Li; He-he Liu (Archives of Microbiology, 2021)

Influence of major water conservation projects on river channels and shorelines in the middle and lower reaches of the Yangtze River - Yue-hua Jiang; He-qin Cheng; Quan-ping Zhou; Yun Li; Guo-qiang Yang; Yang Jin; Shi-jia Mei; Xuan Gu; Hong Zhang (Arabian Journal of Geosciences, 2021)

Fine mapping QTL and mining genes for protein content in soybean by the combination of linkage and association analysis - Xiyu Li; Ping Wang; Kaixin Zhang; Shulin Liu; Zhongying Qi; Yanlong Fang; Yue Wang; Xiaocui Tian; Jie Song; Jiajing Wang; Chang Yang; Xu Sun; et al. (Theoretical and Applied Genetics, 2021)

Effects of Spray Parameters on the Effective Spray Width of Single-Rotor Drone in Sugarcane Plant Protection - Ping Zhang; Wei Zhang; Hai-Tian Sun; Feng-Guang He; Hai-Ba Fu; Li-Qiang Qi; Li-Juan Yu; Li-Yu Jin; Bo Zhang; Jian-Sheng Liu (Sugar Tech, 2021)

Enrichment and characterization of an effective hexavalent chromium-reducing microbial community YEM001 - Yucai Lyu; Tao Yang; Herong Liu; Zheng Qi; Ping Li; Ziyao Shi; Zhen Xiang; Dachun Gong; Ning Li; Yaoping Zhang (Environmental Science and Pollution Research, 2021)

Similar but Distinct Roles of Membrane and Interior Fluid Viscosities in Capsule Dynamics in Shear Flows - Ping Li; Junfeng Zhang (Cardiovascular Engineering and Technology, 2021)

Genome-Wide Identification of Copper Stress-Regulated and Novel MicroRNAs in Mulberry Leaf - Qiuxia Du; Peng Guo; Yisu Shi; Jian Zhang; Danyan Zheng; Yang Li; Adolf Acheampong; Ping Wu; Qiang Lin; Weiguo Zhao (Biochemical Genetics, 2021)

Spatial environment design and comfort simulation of high-latitude building bottom based on geological conditions - Hui Liu; Nan Zhang; Ning Li; Ping Zhang; Xiujuan Jiang (Arabian Journal of Geosciences, 2021)

Quality analysis and improvement of polarimetric synthetic aperture radar (SAR) images from the GaoFen-3 satellite using the Amazon rainforest as an example - Guangde Sun; Zhen Li; Lei Huang; Quan Chen; Ping Zhang (International Journal of Remote Sensing, 2021)

Effects of habitat fragmentation on the demography of the critically endangered tree Pterospermum kingtungense (Sterculiaceae) in Yunnan, China - Chun-Ming Yuan; Shan-Shan Zhang; Guo-Ping Yang; Jian Chen; Yun-Fen Geng; Xiao-Shuang Li; Wen-Zhong Yang (Tropical Ecology, 2021)

Effects of simulated drought stress on carotenoid contents and expression of related genes in carrot taproots - Rong-Rong Zhang; Ya-Hui Wang; Tong Li; Guo-Fei Tan; Jian-Ping Tao; Xiao-Jun Su; Zhi-Sheng Xu; Yong-Sheng Tian; Ai-Sheng Xiong (Protoplasma, 2021)

Analysis of loess landslide mechanism and numerical simulation stabilization on the Loess Plateau in Central China - Wan-li Xie; Qianyi Guo; Jason Y. Wu; Ping Li; Hui Yang; Maosheng Zhang (Natural Hazards, 2021)
Loess landslides have complicated deformation mechanisms. Accurately describing the internal failure deformation of loess landslides and establishing a theoretical method of landslide instability evaluation for the prevention of subsequent landslides have become important topics in western development project construction in China. This paper presents a case study of the Zhonglou Mountain landslide in Shaanxi Province, China. Based on field investigation results, a two-dimensional stability analysis model was constructed using the finite element method. Taking the deformation characteristics of the landslide as the research basis, the distribution laws of the displacement, stress, and shear strain of this landslide were identified with the strength reduction finite element numerical simulation method. Additionally, the safety factor was evaluated under normal and storm conditions. The numerical simulation results show that the horizontal tensile stress of the landslide was mainly distributed in the middle and upper parts of the landslide under normal conditions, while the vertical tensile stress was distributed near the sliding surface. Under heavy rainfall, the sliding force increased, and the anti-sliding force and anti-sliding section decreased; the location of the maximum shear strain shifted down from the middle and upper parts of the landslide body to the area with a shear crack, and the plastic shear strain area expanded along nearly the entire the sliding surface, leading to the occurrence of a landslide. Thus, the use of anti-slide piles to stabilize the landslide was proposed and tested. Monitoring points were arranged along the sliding surface to evaluate the displacement, stress, and strain responses. The on-site observation results agreed with the modeling results. The use of anti-slide piles was demonstrated to be an effective stabilization method for the Zhonglou Mountain landslide.

Tyrosine kinase Fyn promotes apoptosis after intracerebral hemorrhage in rats by activating Drp1 signaling - Li Zhang; Lu Wang; Han Xiao; Hui Gan; Hui Chen; Shuyue Zheng; Dan Jian; Xuan Zhai; Ning Jiang; Zhao Jing; Ping Liang (Journal of Molecular Medicine, 2021)

The Biological Role of Optimized Recombinant Oral Long-Acting Glucagon Like Peptide-1 and Its Impact on the Expression of Genes Associated with Glucose Metabolism of Diabetes - Shan He; Jie Zhang; Tao Wang; Ping Wu; Jianyun Liu; Minggang Li; Baicheng Ma (International Journal of Peptide Research and Therapeutics, 2021)

Groundwater sources, flow patterns, and hydrochemistry of the Central Yinchuan Plain, China - Ying Li; Ping Wu; Xiao-Qin Huang; Bo Zhang; Zhao-Xiang Xu; Yang Li; Jie Li; Lu-Chen Wang; Yu-Fang Sun; Xu-Chen Meng; Cheng-Wen Wang; Zi-Zhao Cai (Hydrogeology Journal, 2021)

Exploring soil erosion trajectories and their divergent responses to driving factors: a model-based contrasting study in highly eroded mountain areas - Chong Jiang; Zhiyuan Yang; Minting Li; Jialing Dai; Xinchi Wang; Haiyan Zhang; Long Yang; Lingling Zhao; Meili Wen; Ping Zhou (Environmental Science and Pollution Research, 2021)

Preface: Selected papers from MEDGEO 2019 conference on recent progress in medical geology - Ping Li; Robert Finkelman; Chaosheng Zhang (Environmental Geochemistry and Health, 2021)

Suppression of miR-4463 promotes phenotypic switching in VSMCs treated with Ox-LDL - Xueqin Wang; Hui Li; Yuetian Zhang; Qi Liu; Xiaolei Sun; Xuemei He; Qian Yang; Ping Yuan; Xiangyu Zhou (Cell and Tissue Research, 2021)

Lentibacillus saliphilus. sp. nov., a moderately halophilic bacterium isolated from a saltern in Korea - Yun Wang; Gang-Qiang Jiang; Hong-Ping Lin; Peng Sun; Hong-Yan Zhang; Dong-Mei Lu; Li-Yun Wang; Chang-Jin Kim; Shu-Kun Tang (Archives of Microbiology, 2021)

SIMS U-Pb geochronology for the Jurassic Yanliao Biota from Bawanggou section, Qinglong (northern Hebei Province, China) - Zhiqiang Yu; Huaiyu He; Gang Li; Chenglong Deng; Haibing Wang; Xinxin Zhang; Qing Yang; Xiao-Ping Xia; Zhonghe Zhou; Rixiang Zhu (International Geology Review, 2021)

Comparison of Long-Term Outcomes of Endoscopic and Minimally Invasive Catheter Evacuation for the Treatment of Spontaneous Cerebellar Hemorrhage - Leiyang Li; Haixiao Liu; Jianing Luo; Zhijun Tan; Junmei Gao; Ping Wang; Wenting Jing; Ruixi Fan; Xiaoyang Zhang; Hao Guo; Hao Bai; Wenxing Cui; et al. (Translational Stroke Research, 2021)
Recently, minimally invasive techniques, including endoscopic evacuation and minimally invasive catheter (MIC) evacuation, have been used for the treatment of patients with spontaneous cerebellar hemorrhage (SCH). However, credible evidence is still needed to validate the effects of these techniques. To explore the long-term outcomes of both surgical techniques in the treatment of SCH. Fifty-two patients with SCH who received endoscopic evacuation or MIC evacuation were retrospectively reviewed. Six-month mortality and the modified Rankin Scale (mRS) score were the primary and secondary outcomes, respectively. A multivariate logistic regression model was used to assess the effects of the different surgical techniques on patient outcomes. In the present study, the mortality rate for the entire cohort was 34.6%. Univariate analysis showed that the surgical technique and preoperative Glasgow Coma Scale (GCS) score affected 6-month mortality. However, no variables were found to be correlated with 6-month mRS scores. Further multivariate analysis demonstrated that 6-month mortality in the endoscopic evacuation group was significantly lower than that in the MIC evacuation group (OR = 4.346, 95% CI 1.056 to 17.886). The 6-month mortality rate in the preoperative GCS 9–14 group was significantly lower than that in the GCS 3–8 group (OR = 7.328, 95% CI 1.723 to 31.170). Compared with MIC evacuation, endoscopic evacuation significantly decreased 6-month mortality in SCH patients. These preliminary results warrant further large, prospective, randomized studies.

The MYB transcription factor Baymax1 plays a critical role in rice male fertility - Xiao-Jiao Xiang; Lian-Ping Sun; Ping Yu; Zheng-Fu Yang; Pei-Pei Zhang; Ying-Xin Zhang; Wei-Xun Wu; Dai-Bo Chen; Xiao-Deng Zhan; Riaz-Muhammad Khan; Adil Abbas; Shi-Hua Cheng; et al. (Theoretical and Applied Genetics, 2021)

Small RNA Sequencing Analysis of Germinating Single-bud Seedcane Sett in Sugarcane - Kai-Chao Wu; Lin Xu; Zhi-Nian Deng; Tian Pang; Rong-Hua Zhang; Yi-Jie Li; Xiao-Yan Liu; Cheng-Feng Huang; Wen-Xian Qin; Jian-Feng Wei; Li-Ping Wei; Yang-Rui Li; et al. (Sugar Tech, 2021)

Antifungal Effects of Fusion Puroindoline B on the Surface and Intracellular Environment of Aspergillus flavus - Ping-Ping Tian; Yang-Yong Lv; Ang Lv; Wen-Jing Yuan; Shuai-Bing Zhang; Na Li; Yuan-Sen Hu (Probiotics and Antimicrobial Proteins, 2021)

The Extraction of Built-up Areas in Chinese Mainland Cities Based on the Local Optimal Threshold Method Using NPP-VIIRS Images - Chen Li; Ping Duan; Mingguo Wang; Jia Li; Birong Zhang (Journal of the Indian Society of Remote Sensing, 2021)

The role of MYB proto-oncogene like 2 in tamoxifen resistance in breast cancer - Xia Li; Xi Zhang; Cong-Cong Wu; Ping-Ping Li; Yi-Mou Fu; Li-Hua Xie; Shuang-Shuang Sun; Ying-Ying Zhou; Bao-Ling Zhu (Journal of Molecular Histology, 2021)

Mass balance reconstruction for Shiyi Glacier in the Qilian Mountains, Northeastern Tibetan Plateau, and its climatic drivers - Hui Zhang; Zhongqin Li; Ping Zhou (Climate Dynamics, 2021)

Numerical simulation of seasonal snow in Tianshan Mountains - Yan-run Ren; Yao-nan Zhang; Jian-sheng Hao; Yong-ping Shen; Guo-hui Zhao; Cong Li (Journal of Mountain Science, 2021)

Improved Oral Bioavailability and Hypolipidemic Effect of Syringic Acid via a Self-microemulsifying Drug Delivery System - Congyong Sun; Wenjing Li; Huiyun Zhang; Michael Adu-Frimpong; Ping Ma; Yuan Zhu; Wenwen Deng; Jiangnan Yu; Ximing Xu (AAPS PharmSciTech, 2021)

Early-Life Multiple Sevoflurane Exposures Alleviate Long-term Anxiety-Like Behaviors in Mice via the proBDNF/ERK Pathway - Ru-Yi Luo; Cong Luo; Feng Zhong; Wei-Yun Shen; Hui Li; Yan-Ling Zhang; Ru-Ping Dai (Molecular Neurobiology, 2021)

Improved control of Frankliniella occidentalis on greenhouse pepper through the integration of Orius sauteri and neonicotinoid insecticides - Qing-cai Lin; Hao Chen; Dirk Babendreier; Jin-ping Zhang; Feng Zhang; Xiao-yan Dai; Zuo-wen Sun; Zhao-peng Shi; Xiao-lin Dong; Guang-an Wu; Yi Yu; Li Zheng; et al. (Journal of Pest Science, 2021)

The impact of urbanization and consumption patterns on China’s black carbon emissions based on input–output analysis and structural decomposition analysis - Zhongci Deng; Ping Kang; Zhen Wang; Xiaoling Zhang; Weijie Li; Yihan Ou; Yu Lei; Ying Dang; Zhongren Deng (Environmental Science and Pollution Research, 2021)

Inversion analysis of the shear strength parameters for a high loess slope in the limit state - Xiao-yan Lin; Lin-fan Zhang; Ze Yang; Ping Li; Tong-lu Li (Journal of Mountain Science, 2021)

Complete genome analysis of a novel iflavirus from a leaf beetle, Aulacophora lewisii - Zhuang-Xin Ye; Yue-Hong Li; Jian-Ping Chen; Chuan-Xi Zhang; Jun-Min Li (Archives of Virology, 2021)

Flavonoids as key bioactive components of Oxytropis falcata bunge, a traditional anti-inflammatory and analgesic Tibetan medicine - Mei-Rong Zhang; Kan Jiang; Jun-Li Yang; Yan-Ping Shi (Natural Product Research, 2020)

Assembly of Satsuma mandarin mitochondrial genome and identification of cytoplasmic male sterility–specific ORFs in a somatic cybrid of pummelo - Shuai Zhang; Zhao-Ping Yin; Xiao-Meng Wu; Chao-Chao Li; Kai-Dong Xie; Xiu-Xin Deng; Jude W. Grosser; Wen-Wu Guo (Tree Genetics & Genomes, 2020)

Correction to: Involvement of proBDNF in Monocytes/Macrophages with Gastrointestinal Disorders in Depressive Mice - Yun-Qing Yu; Yan-Ling Zhang; Zhe Wang; Yu Liu; Hui Li; Chang-Qi Li; Xin-Fu Zhou; Zhao-Lan Hu; Ru-Ping Dai (Neurotoxicity Research, 2020)

Involvement of proBDNF in Monocytes/Macrophages with Gastrointestinal Disorders in Depressive Mice - Yun-Qing Yu; Yan-Ling Zhang; Zhe Wang; Yu Liu; Hui Li; Xin-Fu Zhou; Zhao-Lan Hu; Ru-Ping Dai (Neurotoxicity Research, 2020)

SUMOylation of Pdia3 exacerbates proinsulin misfolding and ER stress in pancreatic beta cells - Na Li; Xi Luo; Qilin Yu; Ping Yang; Zhishui Chen; Xinqiang Wang; Jipin Jiang; Jing Xu; Quan Gong; Decio L. Eizirik; Zhiguang Zhou; Jiajun Zhao; et al. (Journal of Molecular Medicine, 2020)

Culturally Tailored Intervention to Promote Mammography Screening Practice Among Chinese American Women: a Systematic Review - Xuehui Zhang; Ping Li; Pingping Guo; Jie Wang; Na Liu; Shu Yang; Lin Yu; Xiumin Zhang; Wei Zhang (Journal of Cancer Education, 2020)

Valine acts as a nutritional signal in brain to activate TORC1 and attenuate postprandial ammonia-N excretion in Chinese perch (Siniperca chuatsi) - Jie Wang; Xu-Fang Liang; Shan He; Yan-Peng Zhang; Jiao Li; Kang Huang; Lin-Jie Shi; Ping Ren (Fish Physiology and Biochemistry, 2020)

The influences of fly ash on stabilization for Cd in contaminated soils - Ping Wang; Ronghua Li; Di Guo; Zhanyu Guo; Amanullah Mahar; Juan Du; Zengqiang Zhang (Environmental Science and Pollution Research, 2020)

Prevalence and Bayesian Phylogenetics of Enteroviruses Derived From Environmental Surveillance Around Polio Vaccine Switch Period in Shandong Province, China - Chenxu Zhao; Xiaojuan Lin; Feng Ji; Ping Xiong; Yao Liu; Suting Wang; Peng Chen; Qing Xu; Li Zhang; Zexin Tao; Aiqiang Xu (Food and Environmental Virology, 2020)

Groundwater resources survey of tongchuan city using the audio magnetotelluric method - Zhi-min Xu; Jing-tian Tang; Guang Li; Hui-Cui Xin; Zhang-jian Xu; Xin-ping Tan; Jin Li (Applied Geophysics, 2020)

Spatial and Temporal Distributions of Atmospheric CO2 in East China Based on Data from Three Satellites - Bozhen Li; Gen Zhang; Lingjun Xia; Ping Kong; Mingjin Zhan; Rui Su (Advances in Atmospheric Sciences, 2020)

An A 1 -type granite that borders A 2 -type: insights from the geochemical characteristics of the Zongyang A-type granite in the Lower Yangtze River Belt, China - Xiao-Yan Jiang; Kai Wu; Jin-Cheng Luo; Li-Peng Zhang; Wei Dong Sun; Xiao-Ping Xia (International Geology Review, 2020)

MdHAL3, a 4′-phosphopantothenoylcysteine decarboxylase, is involved in the salt tolerance of autotetraploid apple - Shuang Yang; Feng Zhang; Yangshu Wang; Hao Xue; Qiu Jiang; Jiajun Shi; Hongyan Dai; Zhihong Zhang; Linguang Li; Ping He; Yuanyuan Li; Yue Ma (Plant Cell Reports, 2020)

Adult Stress Promotes Purinergic Signaling to Induce Visceral Pain in Rats with Neonatal Maternal Deprivation - Shufen Hu; Qian Sun; Wan-Jie Du; Jian Song; Xin Li; Ping-An Zhang; Ji-Tian Xu; Guang-Yin Xu (Neuroscience Bulletin, 2020)
Chronic visceral pain is one of the primary symptoms of patients with irritable bowel syndrome (IBS), which affects up to 15% of the population world-wide. The detailed mechanisms of visceral pain remain largely unclear. Our previous studies have shown that neonatal maternal deprivation (NMD) followed by adult multiple stress (AMS) advances the occurrence of visceral pain, likely due to enhanced norepinephrine (NE)-β 2 adrenergic signaling. This study was designed to explore the roles of P2X3 receptors (P2X3Rs) in the chronic visceral pain induced by combined stress. Here, we showed that P2X3Rs were co-expressed in β 2 adrenergic receptor (β 2 -AR)-positive dorsal root ganglion neurons and that NE significantly enhanced ATP-induced Ca 2+ signals. NMD and AMS not only significantly increased the protein expression of P2X3Rs, but also greatly enhanced the ATP-evoked current density, number of action potentials, and intracellular Ca 2+ concentration of colon-related DRG neurons. Intrathecal injection of the P2X3R inhibitor A317491 greatly attenuated the visceral pain and the ATP-induced Ca 2+ signals in NMD and AMS rats. Furthermore, the β 2 -AR antagonist butoxamine significantly reversed the expression of P2X3Rs, the ATP-induced current density, and the number of action potentials of DRG neurons. Overall, our data demonstrate that NMD followed by AMS leads to P2X3R activation, which is most likely mediated by upregulation of β 2 adrenergic signaling in primary sensory neurons, thus contributing to visceral hypersensitivity.

Energy conservation and carbon reduction potential for solid waste in China - Minxi Wang; Zhi Li; Lu Chen; Ping Liu; Rui Zhang; Wei Liu; Yu Ma; Yajie Wang; Xin Li (Environmental Science and Pollution Research, 2020)

What factors determine the mass elevation effect of the Tibetan Plateau? - Fang Han; Li Wan; Hong-zhi Wu; Bai-ping Zhang; Lan Gao; Ge Song (Journal of Mountain Science, 2020)