Identification and expression profiling of receptor‐interacting serine/threonine‐protein kinase 2 in Siberian sturgeon ( Acipenser baerii ) - Lu Lu; Shaotong Dai; Hao Zhu; Xin Zhang; Zhiqiong Li; Xiaoli Huang; Ping Ouyang; Yi Geng; Defang Chen (Journal of Fish Biology, 2023)
Receptor‐interacting serine/threonine‐protein kinase 2 (RIPK2) is an adaptor protein of the pattern recognition receptors NOD1 and NOD2 involved in regulating inflammatory response and resisting pathogenic microbial infection. In this study, Acipenser baerii RIPK2 ( AbRIPK2 ) was identified. The open reading frame of AbRIPK2 was 1815 bp encoding 604 amino acids. AbRIPK2 possessed the typical N‐terminal kinase domain (KD) and C‐terminal caspase recruitment domain (CARD). The phylogenetic tree analysis revealed that AbRIPK2 shared a relatively high identity with bony fish. Real‐time fluorescence quantitative PCR (qRT‐PCR) results indicated that AbRIPK2 was highly expressed in the gill, followed by muscle, liver and heart. AbRIPK2 was significantly induced in the spleen and valvular intestine after Streptococcus iniae and Aeromonas hydrophila infection. AbRIPK2 was significantly upregulated after peptidoglycan (PGN) treatment in the splenic leukocytes. This study indicated that AbRIPK2 played a potential role in resisting the pathogenic infection of Siberian sturgeon by responding to bacteria.

The roles of ETS transcription factors in liver fibrosis - Li-Ye Zhang; Yong Tan; Xiao-Jie Luo; Jiang-Feng Wu; Yi-Ran Ni (Human Cell, 2022)

Role of tailing colloid from vanadium-titanium magnetite in the adsorption and cotransport with vanadium - Yi Huang; Dan Zhou; Li Wang; Ganghui Jiao; Hang Gou; Zijing Li; Guanru Zhang (Environmental Science and Pollution Research, 2022)

Highly efficient removal of hexavalent chromium by magnetic Fe–C composite from reed straw and electric furnace dust waste - Fu-Ping Wang; Ya-Nan Zeng; Yi-Tong Wang; Jun-Guo Li; Xi Zhang; Ai-Min Ji; Le-Le Kang; Rui Ji; Qing Yu; Di Gao; Xiao-Man Wang; Zhen Fang (Environmental Science and Pollution Research, 2022)

Mitochondrial DNA mutation affects the pluripotency of embryonic stem cells with metabolism modulation - Juntao Qi; Qi Long; Yang Yuan; Yanshuang Zhou; Jian Zhang; Zifeng Ruan; Liang Yang; Yi Wu; Ge Xiang; Wei Li; Hao Wu; Shiwei Du; et al. (Genome Instability & Disease, 2022)

High Throughput Sequencing Reveals Distinct Bacterial Communities and Functional Diversity in Two Typical Coastal Bays - Liao Ouyang; Xianglan Chen; Wenxuan Zhang; Shuangfei Li; Qiang Huang; Yi Zhang; Chengwei Yan; Shaofeng Li (Journal of Marine Science and Engineering, 2022)
The marine waters in semi-enclosed bays are highly dynamic and strongly influenced by different levels of anthropogenic activity. This study explored the bacterial community composition and diversity in two typical urbanized coastal bay areas (Shenzhen Bay (S) and Dapeng Bay (D)) in Shenzhen, China, based on Illumina NovaSeq sequencing. Seawater analysis showed that coastal area S experienced a higher level of pollution, with higher nutrient concentrations observed. Alpha diversity analysis showed a higher bacterial diversity and richness in coastal area S than D. Taxonomic analysis revealed that the phylum Proteobacteria showed the highest abundance in all samples. Other dominant phyla were Firmicutes, Cyanobacteria, Tenericutes, and Actinobacteria. The bacterial community compositions were significantly different between the two coastal areas. A significant community difference was also found between the sampling sites of coastal area S. However, the difference between sampling sites in coastal area D was not significant. Physicochemical factors showed a more significant effect on bacterial community composition than nutrients. Pearson correlation tests and Network analysis further confirmed that salinity/conductivity, pH, and nitrate were the key factors driving the community difference. PICRUSt analysis revealed a higher degree of functional pathways in coastal area S relating to carbohydrate metabolism, membrane transport, and xenobiotics biodegradation. Our results provide in-depth insights into the bacterial community compositions in typical polluted coastal bays. They may provide information on underlying factors of the assembly process in microbial communities in the coastal zone.

Efficacy and Safety of Recombinant Human Prourokinase in Acute Ischemic Stroke: A Phase IIa Randomized Clinical Trial - Haiqing Song; Yuan Wang; Qingfeng Ma; Huisheng Chen; Bo Liu; Yi Yang; Jianguo Zhu; Shigang Zhao; Xiaoping Jin; Yongqiu Li; Yanyong Wang; Runxiu Zhu; et al. (Translational Stroke Research, 2022)

Identification of PP2C Genes in Tibetan Hulless Barley (Hordeum vulgare var. nudum) Under Dehydration Stress and Initiatory Expression and Functional Analysis of HvPP2C59 - Junjun Liang; Ling Yi; Lilan Li; Haili Zhang; Yunshu Zhang; Guangbing Deng; Hai Long; Maoqun Yu (Plant Molecular Biology Reporter, 2022)

Increasing soil heterogeneity strengthens the inhibition of a native woody plant by an invasive congener - Yi Hu; Zhen-Wei Xu; Ming-Yan Li; Jordan R. Croy; Zhong-Yi Zhang; Hai-Mei Li; Wei-Hua Guo; Xiao-Lei Jiang; Hui-Cui Lu; Xiao Guo (Plant and Soil, 2022)

Causal Association of Cardiac Function by Magnetic Resonance Imaging with Frailty Index: A Mendelian Randomization Study - Hui Zhang; Meng Hao; Zixin Hu; Yi Li; Xiaoxi Hu; Xiaoyan Jiang; Zuyun Liu; Xuehui Sun; Xiaofeng Wang (Phenomics, 2022)

Marine CSEM 3D modeling with a downhole dipole source for natural gas hydrate production monitoring - Ying Liu; Tao He; Yuan Li; Yi Zhang (Marine Geophysical Research, 2022)

Building Instance Change Detection from High Spatial Resolution Remote Sensing Images Using Improved Instance Segmentation Architecture - Li Yan; Jianbing Yang; Yi Zhang (Journal of the Indian Society of Remote Sensing, 2022)

Preliminary Study of the Anther-Specific Gene ZmMYB150 in Maize - Zhuofan Zhao; Yujing Yue; Peng Zhang; Xiaowei Liu; Tian Yang; Yongming Liu; Yu Zheng; Chuan Li; Hongyang Yi; Tao Yu; Moju Cao (Journal of Plant Growth Regulation, 2022)

Genome-Wide Identification Reveals the Potential Functions of the bZIP Gene Family in Common Bean (Phaseolus vulgaris) in Response to Salt Stress During the Sprouting Stage - Qi Zhang; Wen-jing Zhang; Zhen-gong Yin; Wei-jia Li; Chun-Yang Xia; Hao-Yue Sun; Yi-Ming Yang; Hong-Bin Wu; Shuo Zhang; Hao-hao Zhao; Wen-Hui Zhang; Yong-xia Guo; et al. (Journal of Plant Growth Regulation, 2022)

Inhibition of Microglial NLRP3 with MCC950 Attenuates Microglial Morphology and NLRP3/Caspase-1/IL-1β Signaling In Stress-induced Mice - Qing Liu; Man-Man Zhang; Min-Xia Guo; Qiu-Ping Zhang; Na-Zhi Li; Jie Cheng; Shi-Le Wang; Guang-Hui Xu; Cheng-Fu Li; Ji-Xiao Zhu; Li-Tao Yi (Journal of Neuroimmune Pharmacology, 2022)

STING/NF-κB/IL-6-Mediated Inflammation in Microglia Contributes to Spared Nerve Injury (SNI)-Induced Pain Initiation - Jia Sun; Ya-qun Zhou; Bing-yang Xu; Jia-yan Li; Long-qing Zhang; Dan-yang Li; Shuang Zhang; Jia-yi Wu; Shao-jie Gao; Da-wei Ye; Wei Mei (Journal of Neuroimmune Pharmacology, 2022)

Association between gestational arsenic exposure and intrauterine growth restriction: the role of folate content - Fei-Xiang Xu; Xu Chen; Heng Zhang; Yi-Jun Fan; Ya-Ping Song; Jin-Wei Lv; Ya-Li Xie; Yichao Huang; Dao-Zhen Chen; Hua Wang; De-Xiang Xu (Environmental Science and Pollution Research, 2022)

An hourly shallow landslide warning model developed by combining automatic landslide spatial susceptibility and temporal rainfall threshold predictions - Yi-ming Cao; Wei Guo; Yu-ming Wu; Lang-ping Li; Yi-xing Zhang; Heng-xing Lan (Journal of Mountain Science, 2022)

Comprehensive evaluation of hydrological drought characteristics and their relationship to meteorological droughts in the upper Tarim River Basin, central Asia - Yanyun Xiang; Yi Wang; Yaning Chen; Qifei Zhang; Hongwei Li (Frontiers of Earth Science, 2022)

The response of soil organic carbon to climate and soil texture in China - Yi Zhang; Peng Li; Xiaojun Liu; Lie Xiao; Tanbao Li; Dejun Wang (Frontiers of Earth Science, 2022)

Integration of transcriptomics and metabolomics reveals pathways involved in MDSC supernatant attenuation of TGF-β1-induced myofibroblastic differentiation of mesenchymal stem cells - Yin Celeste Cheuk; Xinhao Niu; Yongxin Mao; Jiawei Li; Jiyan Wang; Shihao Xu; Yongsheng Luo; Weixi Wang; Xuanchuan Wang; Yi Zhang; Ruiming Rong (Cell and Tissue Research, 2022)

Long-term dietary restriction ameliorates ageing-related renal fibrosis in male mice by normalizing mitochondrial functions and autophagy - Chun-Hsien Chiang; Sin-Jin Li; Ting-Rui Zhang; Ching-Yi Chen (Biogerontology, 2022)

2022 taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Sergey V. Alkhovsky; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Martina Bandte; Martin Beer; Nicolas Bejerman; Éric Bergeron; et al. (Archives of Virology, 2022)

Immunogenicity and protective efficacy of a DNA vaccine inducing optimal expression of the SARS-CoV-2 S gene in hACE2 mice - Zhuo-xin Li; Sheng Feng; He Zhang; Xin-yu Zhuang; Chao Shang; Shi-yu Sun; Ji-cheng Han; Yu-biao Xie; Jin-yong Zhang; Wei Wang; Cheng-hui Li; Guan-yu Zhao; et al. (Archives of Virology, 2022)

High outcrossing rates in a self‐compatible and highly aggregated host‐generalist mistletoe - Manru Li; Yi Sui; Xuanni Wang; Zhanxia Ma; Yahuang Luo; Sasith Tharanga Aluthwattha; Doyle McKey; Benoit Pujol; Jin Chen; Ling Zhang (Molecular Ecology, 2022)
Plants have evolved various strategies to avoid inbreeding, but the mass flowering displayed by many plants predisposes them to within‐plant pollen movements and self‐pollination. Mistletoes often aggregate at multiple spatial scales. Their bird pollinators often visit several flowers of the same individual and of others on the same host tree. We hypothesized that hermaphroditic mistletoes have self‐incompatibility mechanisms that reduce or prevent selfing. Whether their spatial distribution, affected by host specificity, host distribution, and the behaviour of seed dispersers, influences their mating system and population genetic structure remains unclear. We studied how mating system and spatial distribution affect genetic structure in four populations of the host‐generalist mistletoe Dendrophthoe pentandra in southwestern China using microsatellite markers and progeny arrays. We also characterized the fine‐scale spatial genetic structure among 166 mistletoes from four host trees in one population. Prevalence and intensity of infection both appeared to vary among host species, strongly affecting the degree of aggregation. Host tree size had a strong effect on infection intensity. Surprisingly, manual pollination experiments indicated that D. pentandra is self‐compatible, but genetic analyses revealed that outcrossing rates were higher than expected in all four populations (MLTR t m 0.83–1.20, Bayesian t m 0.772–0.952). Spatial genetic structure was associated with distance between host trees but not at shorter scales (within hosts). Our results demonstrate that the combination of bird pollination, bird‐mediated seed dispersal, and post‐dispersal processes result in outcrossing and maintain relatively high diversity in the presence of biparental inbreeding, despite very high local densities and possible self‐compatibility.

Determining a reasonable distance of collecting irrigation data for real‐time management of furrow irrigation - Wei‐Bo Nie; Zheng‐Jiang Feng; Yi‐Bo Li; Fan Zhang; Xiao‐Yi Ma (Irrigation and Drainage, 2022)
One basis for the real‐time management of furrow irrigation is to estimate the infiltration parameters and Manning roughness, which can represent the furrow condition as early as possible. Closed‐end furrow irrigation experiments were conducted on 45 fields on the Guanzhong Plain in Shaanxi province, China. The infiltration parameters of the Kostiakov equation and Manning roughness were estimated according to multipoint advance trajectory and upstream end water depth at four advance distances (50%, 60%, 70%, and 100% of furrow length; i.e., 0.5 L, 0.6 L, 0.7 L, and 1.0 L, respectively). The estimated infiltration parameter and Manning roughness were then input into WinSRFR to evaluate their effects on furrow irrigation and determine a reasonable distance for collecting multipoint advance trajectory and upstream end water depth. The results indicated that the estimated infiltration parameters and Manning roughness by multipoint advance trajectory and upstream end water depth at 0.6 L or later were highly consistent with the measured values. Except for the upstream end water depth, the mean absolute percentage errors between the simulated advance trajectory, irrigation performance, and applied water volume with measured values were lower than 10% for all furrow irrigation experiments. Therefore, the reasonable distance for collecting irrigation data should not be less than 0.6 L.

The cAMP‐PKA signalling pathway regulates hyphal growth, conidiation, trap morphogenesis, stress tolerance, and autophagy in Arthrobotrys oligospora - Mei‐Chen Zhu; Na Zhao; Yan‐Kun Liu; Xue‐Mei Li; Zheng‐Yi Zhen; Ya‐Qing Zheng; Ke‐Qin Zhang; Jin‐Kui Yang (Environmental Microbiology, 2022)
The cyclic adenosine monophosphate‐protein kinase A (cAMP‐PKA) signalling pathway is evolutionarily conserved in eukaryotes and plays a crucial role in defending against external environmental challenges, which can modulate the cellular response to external stimuli. Arthrobotrys oligospora is a typical nematode‐trapping fungus that specializes in adhesive networks to kill nematodes. To elucidate the biological roles of the cAMP‐PKA signalling pathway, we characterized the orthologous adenylate cyclase AoAcy, a regulatory subunit (AoPkaR), and two catalytic subunits (AoPkaC1 and AoPkaC2) of PKA in A. oligospora by gene disruption, transcriptome, and metabolome analyses. Deletion of Aoacy significantly reduced the levels of cAMP and arthrobotrisins. Results revealed that Aoacy , AopkaR , and AopkaC1 were involved in hyphal growth, trap morphogenesis, sporulation, stress resistance, and autophagy. In addition, Aoacy and AopkaC1 were involved in the regulation of mitochondrial morphology, thereby affecting energy metabolism, whereas AopkaC2 affected sporulation, nuclei, and autophagy. Multi‐omics results showed that the cAMP‐PKA signalling pathway regulated multiple metabolic and cellular processes. Collectively, these data highlight the indispensable role of cAMP‐PKA signalling pathway in the growth, development, and pathogenicity of A. oligospora, and provide insights into the regulatory mechanisms of signalling pathways in sporulation, trap formation, and lifestyle transition.

Derivation of new resistance principle on flow-induced morphological response of flexible vegetation - Feng-Cong Jia; Wei-Jie Wang; Ling-Hua Liu; Jin-Jin Li; Ai-Ping Huang; Jing Zhang; Yi-Cheng Fu; Yang Yu (Environmental Science and Pollution Research, 2022)

Correction to: Increased Soluble Epoxide Hydrolase Activity Positively Correlates with Mortality in Heart Failure Patients with Preserved Ejection Fraction: Evidence from Metabolomics - Liyuan Peng; Ziping Song; Chengcheng Zhao; Kudusi Abuduwufuer; Yanwen Wang; Zheng Wen; Li Ni; Chenze Li; Ying Yu; Yi Zhu; Hualiang Jiang; Jinshan Shen; et al. (Phenomics, 2022)

Immunotherapies for the Effective Treatment of Primary Autoimmune Cerebellar Ataxia: a Case Series - Jiao Li; Bo Deng; Wenli Song; Keru Li; Jingwen Ai; Xiaoni Liu; Haocheng Zhang; Yi Zhang; Ke Lin; Guofu Shao; Chunfeng Liu; Wenhong Zhang; et al. (The Cerebellum, 2022)

Novel hydrophilic straw biochar for the adsorption of neonicotinoids: kinetics, thermodynamics, influencing factors, and reuse performance - Shangzhen Li; Zhihong Zhang; Chao Zhang; Yutian He; Xiaohui Yi; Zhenguo Chen; Mohamed A. Hassaan; Ahmed El Nemr; Mingzhi Huang (Environmental Science and Pollution Research, 2022)

Bioremediation of petroleum hydrocarbon contaminated soil by microorganisms immobilized on sludge modified by non-ionic surfactant - Junlong Yu; Ruyue Li; Xiuxia Zhang; Yi Du; Ruojun Ma; Xiaodong Zhao; Shuai Zuo; Kangning Dong; Ruirui Wang; Yupeng Zhang; Yingying Gu; Juan Sun (Environmental Science and Pollution Research, 2022)

High levels of serum IL-10 indicate disease progression, extramedullary involvement, and poor prognosis in multiple myeloma - Xiaoyan Yue; Linlin Huang; Yang Yang; Yi Zhao; Donghua He; Xiaoyan Han; Gaofeng Zheng; Yi Li; Enfan Zhang; Zhen Cai; Xin Huang; Jingsong He (Journal of Zhejiang University-SCIENCE B, 2022)

MicroRNA-34b-5p binds enhancer of zeste 2 to inhibit milk fat globule-EGF factor 8 expression, affecting liver fibrosis - Jing Ma; Qiyao Liu; Mengxuan Chen; Bo He; Yi Li; Min Zhang; Yongfang Jiang (Journal of Physiology and Biochemistry, 2022)

Proteomic analysis and identification reveal the anti-inflammatory mechanism of clofazimine on lipopolysaccharide-induced acute lung injury in mice - Bo Yang; Zhan Gao; Qi-Shuang Li; Xiang-Ye Zhang; Lan Song; Yi-Ni Wang; Xin-Yue Wang; Lin-Lin Ji; Hong-Liang Xu; Hui Xie; Fu-Kai Feng; Xiao-Ping Li; et al. (Inflammation Research, 2022)

How geographic diversification affects corporate social responsibility? The moderating effects of ownership and environmental regulation - Yi Zhang; Xinyuan Peng; Yuqi Li; Shuke Fu (Environmental Science and Pollution Research, 2022)

Temporal-spatial variation, source forensics of PAHs and their derivatives in sediment from Songhua River, Northeastern China - Rashid Mohammed; Zi-Feng Zhang; Ying-Hua Hu; Chao Jiang; Zhi-Qiang He; Wen-Juan Wang; Yi-Fan Li (Environmental Geochemistry and Health, 2022)

Correction to: Source apportionment and health risk assessment of air pollution particles in eastern district of Chengdu - Yi Huang; Li Wang; Shipeng Zhang; Meng Zhang; Jinjin Wang; Xin Cheng; Ting Li; Min He; Shijun Ni (Environmental Geochemistry and Health, 2022)

Salinimicrobium sediminilitoris sp. nov., Isolated from a Tidal Flat - Cheng-Qiang Xia; Hui-Jing Niu; Kai-Shi Dong; Li Guan; Li-Ping Sun; Qin Wang; Yan-Jiao Zhang; Yi Li; Cai-Xia Pei (Current Microbiology, 2022)

Exploring the Oxidative Stress Regulation of Mice with Hyperglycemia by Lactiplantibacillus plantarum SCS4 - Xiao Meng; Xin-Zhi Chen; Jia-Yi Sun; Ying Zhang; Li-Shi Jiang; Juan Wang (Current Microbiology, 2022)

Surfactin isoforms isolated from a mushroom derived Bacillus halotolerans DMG-7-2 - Guo-Feng Zhou; Lin Yang; Shu-Hua Zhang; Yi Wang; Yu Yang; Rui Xu; Xue Zhao; Dan Nie; Junjie Shan; Cheng-Bin Cui; Chang-Wei Li (Natural Product Research, 2022)

Construction of PDIsa/BiOBr type-I scheme heterojunction for efficient ciprofloxacin photocatalytic degradation - Jinhui Huang; Hanbo Yu; Xingzhong Yuan; Xue Li; Longbo Jiang; Kaixin Yi; Chenyu Zhang (Environmental Science and Pollution Research, 2022)

Numerical and Experimental Research on Rectification Measures for a Contraction Diversion Pier in a Pumping Station - Wentao Xu; Li Cheng; Kailian Du; Lei Yu; Yi Ge; Jiali Zhang (Journal of Marine Science and Engineering, 2022)
In order to improve the flow state of a forebay, a contraction diversion pier is discovered, the geometric parameters of which affect the improvement of the flow state. In this paper, the standard k-ε model in the computational fluid dynamics (CFD) numerical simulation method is used to research the flow state improvement of the forebay with a contraction diversion pier. In our research, the single factor method is used to analyze the influence of different geometric parameters. Then, the optimal geometric parameters of the contraction diversion pier are given. Results show that the contraction diversion pier can be used to concentrate the water flow. In the area where reflux is formed, the contraction diversion guides water flow along the diversion pier wall. In particular, when the retractable diversion pier is located in the middle of a reflux zone, the water backflow is effectively reduced, the flow state is improved, and the inlet condition of the pump is optimized. By comparing the cross-sectional streamlines, the velocity contour, the normal velocity uniformity of the longitudinal section, and the normal weighted mean angle, the optimal geometric parameters of the contraction diversion pier are obtained as follows: the distance from the contraction pier to the inlet sump is 0.1 L, the contraction angle is 20°, and the length of pier is 0.3 L.

Wavefield-reconstructed least-squares reverse time migration with dynamic constraint factor - Yi Ding; Zhenchun Li; Kai Zhang; Yuzhao Lin (Acta Geophysica, 2022)

Isolation and Analysis of Reverse Transcriptase of Ty1-copia-Like Retrotransposons in Sugarcane - Jun-Xian Liu; Jing Liu; Tai-Yi Yang; Li-Min Liu; Li-Hang Qiu; Yi-Jing Gao; Wei-Xing Duan; Jing-Chao Lei; Hong-Jian Liu; Rong-Hua Zhang; Wei-Zhong He; Song Li; et al. (Sugar Tech, 2022)

Identification of serum metabolites enhancing inflammatory responses in COVID-19 - Chen-Song Zhang; Bingchang Zhang; Mengqi Li; Xiaoyan Wei; Kai Gong; Zhiyong Li; Xiangyang Yao; Jianfeng Wu; Cixiong Zhang; Mingxia Zhu; Lei Zhang; Xiufeng Sun; et al. (Science China Life Sciences, 2022)

Phylogenetic relationships and migration patterns of the Fargesia spathacea complex inferred from genomic data - Wan-Wan Li; Yun Zhou; Lei Huang; Yu‐Qu Zhang; Yi Ren; Jia-Ning Yu (Plant Systematics and Evolution, 2022)

Rootstock rescues watermelon from Fusarium wilt disease by shaping protective root-associated microbiomes and metabolites in continuous cropping soils - An-Hui Ge; Zhi-Huai Liang; Li-Li Han; Ji-Ling Xiao; Yi Zhang; Qing Zeng; Ji-Fang Xiang; Chao Xiong; Li-Mei Zhang (Plant and Soil, 2022)

cPKCγ Deficiency Exacerbates Autophagy Impairment and Hyperphosphorylated Tau Buildup through the AMPK/mTOR Pathway in Mice with Type 1 Diabetes Mellitus - Jiayin Zheng; Yue Wang; Yue Liu; Song Han; Ying Zhang; Yanlin Luo; Yi Yan; Junfa Li; Li Zhao (Neuroscience Bulletin, 2022)

Role of Sp1 in atherosclerosis - Jie-Feng Jiang; Zheng-Yang Zhou; Yi-Zhang Liu; Li Wu; Bin-Bin Nie; Liang Huang; Chi Zhang (Molecular Biology Reports, 2022)

Notch1 down-regulation in lineage-restricted niches is involved in the development of mouse eccrine sweat glands - Yuzhen Wang; Bin Yao; Xianlan Duan; Jianjun Li; Wei Song; Enhejirigala; Zhao Li; Xingyu Yuan; Yi Kong; Yijie Zhang; Xiaobing Fu; Sha Huang (Journal of Molecular Histology, 2022)

Identification of a 5-gene-risk score model for predicting luminal A-invasive lobular breast cancer survival - Yi-Huan Chen; Tao-Feng Zhang; Yi-Yuan Liu; Jie-Hua Zheng; Wei-Xun Lin; Yao-Kun Chen; Jie-Hui Cai; Juan Zou; Zhi-Yang Li (Genetica, 2022)

Mycotoxin surveillance on wheats in Shandong province, China, reveals non-negligible probabilistic health risk of chronic gastrointestinal diseases posed by deoxynivalenol - Fenghua Li; Xinglan Duan; Liwen Zhang; Dafeng Jiang; Xianqi Zhao; En Meng; Ran Yi; Chang Liu; Yirui Li; Jia-Sheng Wang; Xiulan Zhao; Wei Li; et al. (Environmental Science and Pollution Research, 2022)

Dynamic networks of P300-related process - Qin Tao; Lin Jiang; Fali Li; Yuan Qiu; Chanlin Yi; Yajing Si; Cunbo Li; Tao Zhang; Dezhong Yao; Peng Xu (Cognitive Neurodynamics, 2022)

Degradation characteristics of crude oil by a consortium of bacteria in the existence of chlorophenol - Jing Li; Qiyou Liu; Shuo Sun; Xiuxia Zhang; Xiuying Zhao; Junlong Yu; Wu Cui; Yi Du (Biodegradation, 2022)

Complete genome analysis of a novel iflavirus from the spotted lanternfly Lycorma delicatula - Yi-Zhe Wang; Zhuang-Xin Ye; Jian‑Ping Chen; Chuan‑Xi Zhang; Jun‑Min Li; Hai-Jian Huang (Archives of Virology, 2022)

Physical model test of the influence of the spillway geometry on the scouring and breaching process of landslide-dammed lakes - Yi-feng Huang; Xiang-miao Zhou; Jia-wen Zhou; Xing-guo Yang; Jie-yuan Zhang; Hai-bo Li (Arabian Journal of Geosciences, 2022)

Effects of ecological restoration on soil biogenic elements and their ecological stoichiometry in the Yellow River Delta, China - Dongxue Li; Yi’na Li; Yiliang Xie; Baoshan Cui; Zhonghua Ning; Shuyan Zhang; Zhenggang Bi; Shouqiang Fu; Chunguang Che (Frontiers in Marine Science, 2022)
Coastal wetlands serve as sources and sinks of carbon, nitrogen, phosphorus, and sulfur, and their ecological stoichiometry intuitively indicates the biogeochemical cycle process of the region. This study investigated the changing trend of the contents of soil organic carbon (i.e., SOC), total nitrogen (i.e., TN), total phosphorus (i.e., TP), and total sulfur (i.e., TS) and their ecological stoichiometric ratios in 2019-2021 in the Yellow River Delta (including north and south banks) under the Internationally Important Wetland Biodiversity Conservation Project by conducting field surveys and experiments. The results showed that SOC, TN, and TP showed the highest content in the North Unrestoration, while the TS content appeared highest in the North Restoration. In addition, ecological restoration improved the biogenic element stability in both banks and improved the stability of ecological stoichiometry on the north bank while decreasing the ecological stoichiometry stability on the south bank. Notably, the changing trend of soil C/S in the North Unrestoration exhibited a considerably different profile similarity from the North Restoration, which indicates that the ecological restoration changed the wetland ecosystem from the perspective of soil C/S. Furthermore, the high content of soil biogenic elements SOC and high ratio of soil ecological stoichiometry C/N and C/S in the Yellow River Delta induce that they are more sensitive to environmental change. Over the three years, the contributions of soil moisture content, soil salinity, and pH to soil biogenic element contents and their stoichiometric ratios were 32.20%, 49.30%, and 18.50% on the north bank, respectively, and 85.70%, 8.50%, and 5.80% on the south bank, respectively. This study implies that ecological restoration generally has a positive effect on the soil biogenic element contents and their ecological stoichiometry in the Yellow River Delta and provides a reference for delta restoration.

Bioconversion of food waste to crayfish feed using solid-state fermentation with yeast - Qinping Li; Puhong Yi; Jianze Zhang; Yudong Shan; Yongfeng Lin; Ming Wu; Kun Wang; Guangming Tian; Ji Li; Tingheng Zhu (Environmental Science and Pollution Research, 2022)

Histone methyltransferase GLP epigenetically activates GPCPD1 to sustain cancer cell metastasis and invasion - He Wen; Minghui Shu; Jia-Yi Chen; Xiaofan Li; Qian Zhu; Jun Zhang; Yuan Tian; Xiaopeng Lu; Wei-Guo Zhu (Genome Instability & Disease, 2022)
Disordered choline metabolism is associated with tumor progression. Glycerophosphocholine phosphodiesterase 1 (GPCPD1) is critical for cleaving glycerophosphocholine (GPC) to produce choline. However, whether and how GPCPD1 is epigenetically regulated remains largely unknown. In the current study, we report that histone H3 lysine 9 (H3K9) methyltransferase GLP (G9a-like Protein) is essential for transcriptional activation of GPCPD1 through H3K9me1 to promote tumor cell migration and invasion. Knocking down GLP or inhibiting its methyltransferase activity impaired GPCPD1 expression and decreased the choline levels. Importantly, we confirmed that both GPCPD1 and choline levels are positively correlated with cancer cell migration. The reduced migration and invasion of GPCPD1-knockdown cells were rescued by choline treatment. Interestingly, GPCPD1 gene expression was found regulated by transcription factor Krüppel-like Factor 5 (KLF5). KLF5 recruitment was GLP-dependent and was indispensable for GPC-induced GPCPD1 expression. These data suggest that GLP promotes tumor cell migration and invasion by transcriptionally activating GPCPD1 . GLP and KLF5 are potential therapeutic targets in future cancer treatment.

Investigation on the influence of the Bohai Sea Geological Environment on the submarine stratum stability based on data mining: an intelligent prediction model - Xin Li; Chao Jia; Hualin Zhao; Yongbo Teng; Yi Zhang; Pengpeng Zhang (Environmental Science and Pollution Research, 2022)

Permian-Triassic magmatic and thermal events in the Dunhuang orogenic belt: implications for subduction records of the Paleo-Asian Ocean - Qian W.L. Zhang; Yi-Chao Chen; Meng-Yan Shi; Zhen M.G. Li; Jia-Hui Liu; Chun-Ming Wu (International Geology Review, 2022)

Abrupt fluctuations in North Pacific Intermediate Water modulated changes in deglacial atmospheric CO2 - Yanguang Liu; Yue Qiu; Dongling Li; Antonina V. Artemova; Yuying Zhang; Aleksandr A. Bosin; Sergey A. Gorbarenko; Qingsong Liu; Debo Zhao; Longbin Sha; Yi Zhong (Frontiers in Marine Science, 2022)
As a major reservoir of heat and CO 2 , the Pacific Ocean is an important component of the global climate system, but the nature of its circulation under different climatic conditions remains poorly understood. We present sedimentary records of surface water hydrography and nutrient dynamics from the subarctic Pacific Ocean, with the aim of investigating changes in sea-ice coverage, biological productivity, and sea surface temperature in the subarctic Northwest Pacific since 32 kyr. Our records indicate an enhanced North Pacific surface water stratification from the last glacial to Heinrich Stadial 1, which generally limited the siliceous productivity supply to the surface water. A productivity peak during the Bølling/Allerød warm interval was associated with an increase in the atmospheric p CO 2 , and it was driven by the increased supply of nutrient- and CO 2 -rich waters. This process can be attributed to the collapse of the North Pacific Intermediate Water formation at the onset of the Bølling/Allerød interstadial. Moreover, a northward shift of the westerly winds and the gyre boundary could have modulated the expansion of the subpolar gyre, driving changes in poleward heat transport, biogeochemistry, and the hydroclimate of the North Pacific. Our results are consistent with modern evidence for a northward shift of the westerlies in response to global warming, which will likely result in CO 2 outgassing from the subarctic Pacific Ocean in the future.

Mitochondria-targeted cyclometalated iridium (III) complex for H2S-responsive intracellular redox regulation as potent photo-oxidation anticancer agent - Ben Liu; Xu Huang; Meng Hu; Zhiyin Chen; Wei Zhang; Yi Li (JBIC Journal of Biological Inorganic Chemistry, 2022)

Effect modification by aging on the associations of nicotine exposure with cognitive impairment among Chinese elderly - Jian Hou; Chao Huang; Bo Zhu; Wei Liu; Qing-qing Zhu; Lu Wang; Tian Li; Chun-jie Yuan; Shao-yang Lai; De-sheng Wu; Fei-qi Zhu; Jia-fei Zhang; et al. (Environmental Science and Pollution Research, 2022)

JSH-Net: joint semantic segmentation and height estimation using deep convolutional networks from single high-resolution remote sensing imagery - Bin Zhang; Yi Wan; Yongjun Zhang; Yansheng Li (International Journal of Remote Sensing, 2022)

Exploring the R-ISS stage-specific regular networks in the progression of multiple myeloma at single-cell resolution - Ling Zhong; Xiao Yang; Yu Zhou; Jialing Xiao; Huan Li; Jiang Tao; Qian Xi; Chen Chu; Chenglong Li; Xi Yang; Chen Yang; Yi Zhang; et al. (Science China Life Sciences, 2022)

A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic options - Yuntao Liu; Lan Song; Nairen Zheng; Jinwen Shi; Hongxing Wu; Xing Yang; Nianci Xue; Xing Chen; Yimin Li; Changqing Sun; Cha Chen; Lijuan Tang; et al. (Science China Life Sciences, 2022)

Establishment and application of a human osteosarcoma U-2OS cell line that can stably express Cas9 protein - Yonghua Zhou; Yingjie Li; Yu Zhang; Zilin Yi; Minggui Jiang (Molecular and Cellular Biochemistry, 2022)

Two new clerodane diterpenoids and a new pyran-2-one derivative with anti-neuroinflammatory activities from Croton crassifolius - Zhi-Peng Ling; Qing Tang; Can-Jie Li; Jin-Lin Tan; Hai-Yue Zhao; Yi-Kun Hao; Zhao-Chun Zhan; Zhong-Nan Wu; Yu-Bo Zhang; Qing Zheng; Guo-Cai Wang (Journal of Natural Medicines, 2022)

Validity Analysis of the Morphological Identification of Three Highly Morphologically Similar Species Belonging to the Genus Niviventer (Rodentia: Muridae) - Yao-Yao Li; Hao-Tian Li; Jia-Wei Hao; Chen-Yi Zhang; Guan-Ze Liu; Xing-Han Lin; Xiao-Qing Sun; Guo-Chen Zang; Yu-Chun Li (Journal of Mammalian Evolution, 2022)

Ethnicity evaluation of ferric pyrophosphate citrate among Asian and Non-Asian populations: a population pharmacokinetics analysis - Lingxiao Zhang; Liangying Gan; Kexin Li; Panpan Xie; Yan Tan; Gang Wei; Xiaojuan Yuan; Raymond Pratt; Yongchun Zhou; Ai-Min Hui; Yi Fang; Li Zuo; et al. (European Journal of Clinical Pharmacology, 2022)
Purpose To evaluate the potential ethnic differences of ferric pyrophosphate citrate (FPC, Triferic) in healthy subjects and patients with hemodialysis-dependent stage 5 chronic kidney disease (CKD-5HD) and identify covariates that may influence pharmacokinetics (PK) of FPC. Methods Data were collected from 2 Asian and 4 non-Asian clinical studies involving healthy subjects and CKD-5HD patients. Three population PK models were developed: M1 for intravenous (IV) administration of FPC in healthy subjects; M2 for dialysate administration of FPC in CKD-5HD patients; M3 for pre-dialyzer administration of FPC in CKD-5HD patients. All the models were fitted to concentration versus time data of FPC using the nonlinear mixed effect approach with the NONMEM ® program. All statistical analyses were performed using SAS version 9.4. Results In total, 26 Asians and 65 non-Asians were included in the final model analysis database. Forty healthy subjects were administered FPC via intravenous (IV) route and 51 patients with CKD-5HD via dialysate ( N = 50) and pre-dialyzer blood circuit administration ( N = 51). The PK parameters of FPC IV were similar. The population PK model showed good parameter precision and reliability as shown by model evaluation, and no relevant influence of ethnicity on PK parameters was observed. In healthy subjects, the maximum observed plasma concentration (C max ) and area under the plasma concentration–time curve (AUC) decreased with increase in lean body mass (LBM) and the average serum total iron at 6 h before the baseline period (Fe av ), whereas, in both patient populations, C max and AUC decreased with increase in LBM and decrease in Fe baseline . Other factors such as gender, age, Fe av , and ethnicity had no influence on PK exposures in patients. The influence of LBM on PK exposures in patients was smaller than that in healthy subjects (ratio of AUC 0-24 for the 5th [68 kg] and 95th [45 kg] patient’s LBM was almost 1). The influence of Fe av and LBM on PK exposures was < 50%. Conclusion The population pharmacokinetics model successfully described the PK parameters of FPC in healthy subjects and CKD-5HD patients and were comparable between Asian and non-Asian populations.

Relationship between exposure to cadmium, lead, and mercury and the occurrence of urinary incontinence in women - Jinliang Ni; Ziye Li; Yi Lu; Houliang Zhang; Guangchun Wang; Jinbo Xie; Jun Xie; Yidi Wang; Yifan Zhang; Keyi Wang; Weipu Mao; Bo Peng (Environmental Science and Pollution Research, 2022)

Higher levels of nonylphenol were found in human urine and drinking water from rural areas as compared to metropolitan regions of Wuhan, China - Chunyan Xu; Haibo Ling; Chuangang Fan; Luojing Xiang; Shu Zhang; Weiwei Li; Chuan Yi (Environmental Science and Pollution Research, 2022)
The suspected endocrine disruptor nonylphenol (NP) is closely associated with anthropogenic activities; therefore, studies on this compound have been clustered in urban areas. This study investigated the NP concentrations in drinking water sources ( n = 8), terminal tap water ( n = 36), and human urine samples ( n = 127) collected from urban and rural areas in Wuhan, China. The mean concentrations of NP measured in drinking water sources in urban and rural areas were 92.3 ± 7.5 and 11.0 ± 0.8 ng/L (mean ± SD), respectively, whereas the mean levels in urban and rural tap waters were 5.0 ± 0.7 and 44.2 ± 2.6 ng/L (mean ± SD), respectively. Nevertheless, NP was detected in 74.1% and 75.4% of the human urine samples from urban and rural participants, with geometric mean concentrations of 0.19 ng/mL (0.26 µg/g creat) and 0.27 ng/mL (0.46 µg/g creat), respectively. Although the NP concentrations measured in the drinking water sources of urban areas were significantly higher than those in rural areas ( P < 0.05), the tap water and urine NP concentrations measured in urban areas were unexpectedly lower than those of rural areas ( P < 0.05). Additionally, this investigation showed that the materials comprising household water supply pipelines and drinking water treatment processes in the two areas were also different. Our results indicated that the levels of exposure to NP in drinking water and human urine in rural areas were not necessarily lower than those in urban areas. Thus, particular attention should be paid to rural areas in future studies of NP.

Phthalate exposure enhances incidence of urinary incontinence: US NHANES, 2003–2004 and 2005–2006 - Xianyanling Yi; Kun Jin; Shi Qiu; Xingyu Xiong; Tianyi Zhang; Ge Peng; Dazhou Liao; Xiaonan Zheng; Hang Xu; Hong Li; Lu Yang; Qiang Wei; et al. (Environmental Science and Pollution Research, 2022)

A frequency ratio–based sampling strategy for landslide susceptibility assessment - Lei-Lei Liu; Yi-Li Zhang; Ting Xiao; Can Yang (Bulletin of Engineering Geology and the Environment, 2022)

Novel SNPs in the 3′UTR Region of GHRb Gene Associated with Growth Traits in Striped Catfish (Pangasianodon hypophthalmus), a Valuable Aquaculture Species - Liang-Sen Jiang; Zhuo-Hao Ruan; Zhi-Qiang Lu; Yi-Fu Li; Yuan-Yuan Luo; Xi-Quan Zhang; Wen-Sheng Liu (Fishes, 2022)
The striped catfish, Pangasianodon hypophthalmus is an important freshwater aquaculture species in Southeast Asian countries due to its rapid growth. The growth hormone receptor (GHR) is a significant regulatory factor for the growth axis and has great potential applications in animal genetic breeding. This study aims to characterize the GHRb cDNA of the striped catfish and analyze the distribution of its mRNA. Screening of single nucleotide polymorphisms’ (SNPs) loci and diplotypes was performed to provide basic information for the assisted selection of molecular markers in genetic breeding. The results showed that the GHRb cDNA of striped catfish had 2791 bp, which encoded for 569 amino acids. In a phylogenyic study, the ghrb of the striped catfish was clustered with those of other catfish and they were highly homologous. Quantitative real-time PCR (qRT-PCR) experiments showed that GHRb mRNA was expressed in ten different organs of the striped catfish, with the highest expression level in the liver. Five SNP and a haplotype block were identified in the 3′UTR of the GHRb gene using the direct sequencing of 307 individuals. Three haplotypes were found and four diplotypes were constructed. The association analysis revealed that these polymorphisms were significantly associated with growth traits in the striped catfish (p

Potential millennial‐scale avian declines by humans in southern China - Feng Dong; Qiang Zhang; Yi‐Lin Chen; Fu‐Min Lei; Shou‐Hsien Li; Fei Wu; Xiao‐Jun Yang (Global Change Biology, 2022)
Mounting observational records demonstrate human‐caused faunal decline in recent decades, while accumulating archaeological evidence suggests an early biodiversity impact of human activities during the Holocene. A fundamental question arises concerning whether modern wildlife population declines began during early human disturbance. Here, we performed a population genomic analysis of six common forest birds in East Asia to address this question. For five of them, demographic history inference based on 25–33 genomes of each species revealed dramatic population declines by 4‐ to 48‐fold over millennia (e.g. 2000–5000 thousand years ago). Nevertheless, summary statistics detected nonsignificant correlations between these population size trajectories and Holocene temperature variations, and ecological niche models explicitly predicted extensive range persistence during the Holocene, implying limited demographic consequence of Holocene climate change. Further analyses suggest high negative correlations between the reconstructed population declines and human disturbance intensities and indicate a potential driver of human activities. These findings provide a deep‐time and large‐scale insight into the recently recognized avifaunal decline and support an early origin hypothesis of human effects on biodiversity. Overall, our study sheds light on the current biodiversity crisis in the context of long‐term human–environment interactions and offers a multi‐evidential framework for quantitatively assessing the ecological consequences of human disturbance.

VGLUT3 neurons in median raphe control the efficacy of spatial memory retrieval via ETV4 regulation of VGLUT3 transcription - Aodi He; Chen Zhang; Xiao Ke; Yao Yi; Quntao Yu; Tongmei Zhang; Hongyan Yu; Huiyun Du; Hao Li; Qing Tian; Ling-Qiang Zhu; Youming Lu (Science China Life Sciences, 2022)

Canagliflozin mitigates ferroptosis and ameliorates heart failure in rats with preserved ejection fraction - Sai Ma; Li-Li He; Guo-Rui Zhang; Qing-Juan Zuo; Zhong-Li Wang; Jian-Long Zhai; Ting-Ting Zhang; Yan Wang; Hui-Juan Ma; Yi-Fang Guo (Naunyn-Schmiedeberg's Archives of Pharmacology, 2022)
Recently, hypoglycemic drugs belonging to sodium-glucose cotransporter 2 inhibitors (SGLT2i) have generated significant interest due to their clear cardiovascular benefits for heart failure with preserved ejection fraction (HFpEF) since there are no effective drugs that may improve clinical outcomes for these patients over a prolonged period. But, the underlying mechanisms remain unclear, particularly its effects on ferroptosis, a newly defined mechanism of iron-dependent non-apoptotic cell death during heart failure (HF). Here, with proteomics, we demonstrated that ferroptosis might be a key mechanism in a rat model of high-salt diet-induced HFpEF, characterized by iron overloading and lipid peroxidation, which was blocked following treatment with canagliflozin. Data are available via ProteomeXchange with identifier PXD029031. The ferroptosis was evaluated with the levels of acyl-CoA synthetase long-chain family member 4, glutathione peroxidase 4, ferritin heavy chain 1, transferrin receptor, Ferroportin 1, iron, glutathione, malondialdehyde, and 4-hydroxy-trans-2-nonenal. These findings highlight the fact that targeting ferroptosis may serve as a cardioprotective strategy for HFpEF prevention and suggest that canagliflozin may exert its cardiovascular benefits partly via its mitigation of ferroptosis.

miR-517b-3p promotes the progression of portal vein tumor thrombus via activating Wnt/β-catenin signaling pathway in hepatocellular carcinoma - Rui-Sheng Ke; Kun-Zhai Huang; De-sheng Bao; Jing-Rui Yang; Hua-xiang Wang; Li-Zhi Lv; Yi Jiang; Zhao-Hui Liu; Fu-Xing Zhang (Molecular Biology Reports, 2022)

The contribution of nirK gene-containing thaumarchaea to denitrification and N2O production across coastal sediment and terrestrial ecosystems - Bing Han; Si-Yi Liu; Li-Li Han; Xiao-Tong Song; Liu-Ying Mo; Li-Mei Zhang (Journal of Soils and Sediments, 2022)

Nucleotide polymorphisms of the maize ZmCWINV3 gene and their association with ear-related traits - Minyan Zhu; Yue Lu; Rujia Chen; Tianyun Tao; Zihui Zhang; Yu Zhao; Zhihao Zuo; Yi Ji; Enying Zhang; Derong Hao; Pengcheng Li; Yang Xu; et al. (Genetic Resources and Crop Evolution, 2022)

A review of spatiotemporal patterns of neonicotinoid insecticides in water, sediment, and soil across China - Zhikun Liu; Leiming Zhang; Zulin Zhang; Lihui An; Rupert Hough; Peng Hu; Yi-Fan Li; Fuxiang Zhang; Shuang Wang; Yunqing Zhao; Yuxin Ke; Song Cui (Environmental Science and Pollution Research, 2022)

DSCAM-AS1 promotes cervical carcinoma cell proliferation and invasion via sponging miR-338-3p - Chunmei Li; Xiaoqiong Li; Yi Zhang; Liangzhi Wu; Jingjun He; Nan Jiang; Hui Zhao; Wenwen Liu (Environmental Science and Pollution Research, 2022)

Mental health conditions and academic burnout among medical and non-medical undergraduates during the mitigation of COVID-19 pandemic in China - Qian Yang; Yueheng Liu; Winson Fuzun Yang; Pu Peng; Shubao Chen; Yunfei Wang; Xin Wang; Manyun Li; Yingying Wang; Yuzhu Hao; Li He; Qianjin Wang; et al. (Environmental Science and Pollution Research, 2022)
The outbreak of the novel coronavirus disease 2019 (COVID-19) has posed a great impact on people’s mental health, especially for undergraduate students. This study aimed to compare the mental health conditions and academic burnout between medical and non-medical undergraduates in China when the COVID-19 pandemic is mitigating. A cross-sectional online survey was conducted among 4,972 undergraduates between October 2020 and April 2021, when the pandemic was basically under control. The survey included basic demographics information and standardized scales to evaluate depression, anxiety, perceived stress, daytime sleepiness, alcohol abuse/dependence, quality of life, fatigue, and academic burnout. Compared with medical undergraduates, non-medical undergraduates had higher rates of moderate to severe depression symptoms (29.1% vs. 17.9%, P < 0.001), moderate to severe anxiety symptoms (19.7% vs. 8.9%, P < 0.001), alcohol abuse/dependence (16.3% vs.10.3%, P < 0.001), excessive daytime sleepiness (47.4% vs. 43.4%, P = 0.018), high perceived stress (34.7% vs. 22.2%, P < 0.001), high level of fatigue (51.8% vs. 42.2%, P < 0.001), low QOL (35.8% vs. 21.4%, P < 0.001), and higher academic burnout score (59.4 vs. 57.5, P < 0.001). Being non-medical undergraduates, depression, alcohol abuse/dependence, excessive daytime sleepiness, and high perceived stress were positively associated with academic burnout, while high QOL was negatively associated with the burnout (all P < 0.001). Excessive daytime sleepiness was the strongest predictor for academic burnout.

Brain structural changes in regions within the salience network in patients with functional constipation - Zhenzhen Jia; Guanya Li; Yang Hu; Hao Li; Wenchao Zhang; Jia Wang; Lei Zhang; Zongxin Tan; Shuai Lv; Karen M. von Deneen; Shijun Duan; Guangbin Cui; et al. (Brain Imaging and Behavior, 2022)

Influence of nitrogen wet deposition on nitrogen output in a typical watershed in the Three Gorges Reservoir Area - Chen-dong Lu; Liu-yi Zhang; Kun Yan; Yu-kuan Wang; Shan-gao Xiong; Chen-tao Huang; Ting-zhen Li; Mao-fei Ni (Journal of Mountain Science, 2022)

Circular RNA circPBX3 promotes cisplatin resistance of ovarian cancer cells via interacting with IGF2BP2 to stabilize ATP7A mRNA expression - Lihua Fu; Dan Zhang; Nuo Yi; Yanjun Cao; Yaxian Wei; Wenjing Wang; Li Li (Human Cell, 2022)

Polystyrene microplastics alter bioaccumulation, and physiological and histopathological toxicities of cadmium in the polychaete Perinereis aibuhitensis - Yi Cong; Yadi Lou; Huan Zhao; Zhaochuan Li; Mingxing Zhang; Fei Jin; Ying Wang; Juying Wang (Frontiers in Marine Science, 2022)
Heavy metal (HM) pollution in the marine environment has been of concern for decades. The potential impact of HMs carried by emerging marine pollutants such as microplastics (MPs) has attracted attention only in recent years. In this study, we investigated the single and combined chronic toxic effects (growth, burrowing behavior, and histopathology) of cadmium (Cd, three concentrations of low, medium, and high) and polystyrene (PS) microspheres (1 μm, 10 μg/L) on the coastal polychaete Perinereis aibuhitensis . Cd bioaccumulation under two exposure scenarios was also explored. Our results showed that Cd and PS did not affect worm growth for single or combined exposure, while 13.08 μg/L of Cd (Cd L ) alone significantly decreased the burrowing time of P. aibuhitensis in sediment. The presence of PS mitigated the hormetic effect of Cd on worm burrowing behavior, and this influence was Cd concentration-related. Cd body burdens in worms exposed to the medium and high Cd concentrations (Cd M and Cd H ) were significantly greater than those of control worms with or without the presence of PS. In addition, Cd bioaccumulation was significantly higher with the coexistence of PS than those of Cd alone at the Cd L and Cd M groups. Histopathological analyses demonstrated a trend of epidermal and intestinal damages for single Cd/PS and their combined groups, and the contribution of PS-MPs should not be ignored. Our results indicate that the toxic effects and bioaccumulation pattern of Cd could be altered with the presence of PS-MPs for P. aibuhitensis , especially at environmentally relevant concentrations.

Functional Characterization of the Monogalactosyldiacylglycerol Synthase Gene ptMGD2 in the Diatom Phaeodactylum tricornutum - Shuo Shang; Ruyi Liu; Ling Luo; Xitong Li; Shengqiang Zhang; Yi Zhang; Peng Zheng; Zhuo Chen; Baoshan Wang (Frontiers in Marine Science, 2022)
Monogalactosyldiacylglycerol (MGDG) is the most abundant polar lipid in thylakoid membrane, wherein it plays critical roles related to thylakoid membrane assembly and function in diatoms. However, diatom MGDG biosynthesis has not been fully characterized. In this study, we investigated the role of a novel MGDG synthase (ptMGD2), which is one of the key enzymes for MGDG biosynthesis, in the model diatom Phaeodactylum tricornutum . An analysis of subcellular localization demonstrated that the ptMGD2 is mainly localized in plastids. Gene disruption by gene editing of ptMGD2 resulted in delayed growth, decrease in oxygen evolution rate, reduced MGDG and digalactosyldiacylglycerol (using MGDG as the substrate) content as well as lipid remodeling. Considered together, these observations provide novel insights into the importance of ptMGD2 for regulating MGDG biosynthesis and its potential roles in biotechnical application of Phaeodactylum .

Species and Functional Dynamics of the Demersal Fish Community and Responses to Disturbances in the Pearl River Estuary - Zeyu Zeng; William W. L. Cheung; Han Lai; Huadong Yi; Sheng Bi; Haiyang Li; Xiaoli Chen; Yuqin Su; Xuange Liu; Qiuxian Chen; Zhilun Zhang; Xuchong Wei; et al. (Frontiers in Marine Science, 2022)
Fishery resources are threatened by environmental changes and anthropogenic pressures, particularly in coastal ecosystems. It is crucial to understand the changes of fish communities and their responses to environmental changes and human disturbances to formulate rational fisheries and ecosystem-based management. The Pearl River Estuary (PRE) is a typical sub-tropic coastal ecosystem located in the center of the Guangdong-Hong Kong-Macao Greater Bay Area in the northern South China Sea. The demersal fish in the PRE is traditionally targeted as commercial fishing and severely impacted by overexploitation and hypoxia in the last few decades. In this study, we analyze the fish survey data during the period of 2020~2021 using multivariate statistics to investigate the impacts of human disturbances on the species and functional dynamics of the demersal fish community in the PRE. The results reveal that dissolved oxygen and temperature have significant correlations with the functional traits of the demersal fish community. The impacts of hypoxia on the demersal fish vary with species and locations. We found that the mean functional redundancy of the demersal fish community in the PRE was high across three surveys, but the functional diversity was low in this region. The abundance and richness of the demersal fish community increased during the summer fishing moratorium in the South China Sea in 2021, but the functional diversity did not increase significantly. We conclude that the high functional redundancy in the PRE might not be sufficient to buffer against environmental disturbances because of its low functional diversity. Our study highlights the complicated interactions between the demersal fish community and disturbances in the PRE. Understanding the traits structure and functional diversity of the fish community can help elucidate the factors determining the dynamic responses of the fish community to disturbances.

Metatranscriptomic analysis of host response and vaginal microbiome of patients with severe COVID-19 - Meng Xiao; Bo Lu; Rui Ding; Xia Liu; Xian Wu; Yaqian Li; Xudong Liu; Lin Qiu; Zhibo Zhang; Jing Xie; Yu Chen; Dong Zhang; et al. (Science China Life Sciences, 2022)

Belowground processes and sustainability in agroecosystems with intercropping - Rui-Peng Yu; Hao Yang; Yi Xing; Wei-Ping Zhang; Hans Lambers; Long Li (Plant and Soil, 2022)

Multiple Mild Stimulations Reduce Membrane Distribution of CX3CR1 Promoted by Annexin a1 in Microglia to Attenuate Excessive Dendritic Spine Pruning and Cognitive Deficits Caused by a Transient Ischemic Attack in Mice - Lu Zheng; Yi Wang; Bin Shao; Huijuan Zhou; Xing Li; Cai Zhang; Ning Sun; Jing Shi (Neuroscience Bulletin, 2022)

Beta-Boswellic Acid Protects Against Cerebral Ischemia/Reperfusion Injury via the Protein Kinase C Epsilon/Nuclear Factor Erythroid 2-like 2/Heme Oxygenase-1 Pathway - Mingming Wang; Jiaoyan Yu; Qi Yang; Chao Guo; Wei Zhang; Weiwei Li; Yan Weng; Yi Ding; Jingwen Wang (Molecular Neurobiology, 2022)

PPARγ Dysfunction in the Medial Prefrontal Cortex Mediates High-Fat Diet-Induced Depression - Cong-Cong Fu; Xin-Yi Zhang; Liu Xu; Hui-Xian Huang; Shuang Xu; Qiao-Qi Wu; Zhen Wang; Xi Gu; Li-Fang Lin; Song Lin; Ying-Ying Fang; Xiong Cao; et al. (Molecular Neurobiology, 2022)

Protective effect of nicorandil against myocardial ischemia/reperfusion injury mediated via IL33/ST2 signaling pathway - Yi Zheng; Xueyin Li; Fan Zhang; Bo Zhao; Wanting Du; Da Sun; Guangping Li (Molecular and Cellular Biochemistry, 2022)

Bioactive constituents of animal-derived traditional Chinese medicinal materials for breast cancer: opportunities and challenges - Chaochao Yu; Yi Li; Guopeng Chen; Chaoyan Wu; Xiuping Wang; Yingwen Zhang (Journal of Zhejiang University-SCIENCE B, 2022)

From “blood transfusion” to “hematopoiesis”: watershed eco-compensation in China - Xiuhong Li; Yizhuo Wang; Rongjin Yang; Le Zhang; Yi Zhang; Qiang Liu; Zhenwei Song (Environmental Science and Pollution Research, 2022)

Spatiotemporal variation and driving forces of NDVI from 1982 to 2015 in the Qinba Mountains, China - Yaru Zhang; Yi He; Yanlin Li; Liping Jia (Environmental Science and Pollution Research, 2022)

Short-term effect of sulfur dioxide (SO2) change on the risk of tuberculosis outpatient visits in 16 cities of Anhui Province, China: the first multi-city study to explore differences in occupational patients - Xin-Qiang Wang; Jia-Wen Zhao; Kang-Di Zhang; Wen-Jie Yu; Jie Wang; Ying-Qing Li; Xin Cheng; Zhen-Hua Li; Yi-Cheng Mao; Cheng-Yang Hu; Kai Huang; Kun Ding; et al. (Environmental Science and Pollution Research, 2022)

Effect of maternal thallium exposure in early pregnancy on the risk of preterm birth - Xi Chen; Li Huang; Qian Li; Xu Zhang; Xiaoyi Wang; Guoqiang Sun; Nianhua Yi; Guoping Xiong; Xuefeng Yang; Liping Hao; Hongying Yang; Nianhong Yang (Environmental Science and Pollution Research, 2022)

Thermal equation of state of Cr-pyrope: implications for entrapment pressure of Cr-pyrope inclusion in diamond - Jingui Xu; Dawei Fan; Bo Li; Sergey N. Tkachev; Dongzhou Zhang; Guangzhong Yang; Yi Zhou; Jiamei Song; Wenge Zhou (Contributions to Mineralogy and Petrology, 2022)

Alterations in Functional and Structural Connectivity of Basal Ganglia Network in Patients with Obesity - Zongxin Tan; Yang Hu; Gang Ji; Guanya Li; Yueyan Ding; Wenchao Zhang; Jia Wang; Zhenzhen Jia; Lei Zhang; Hao Li; Karen M. von Deneen; Yu Han; et al. (Brain Topography, 2022)

Use of the MaxEnt model to predict changes in sloth bear (Melursus ursinus) habitats in the Gandaki River Basin, Nepal - Raju Rai; Yi-li Zhang; Zhao-feng Wang; Basanta Paudel; Lin-shan Liu; Mohan Kumar Rai; Narendra Raj Khanal (Journal of Mountain Science, 2022)

Testing the transfer functions for the Geonor T-200B and Chinese standard precipitation gauge in the central Qinghai—Tibet Plateau - Le-le Zhang; Li-ming Gao; Ji Chen; Lin Zhao; Ke-long Chen; Jing-yi Zhao; Guo-jun Liu; Ting-xi Song; Yan-kun Li (Journal of Mountain Science, 2022)

A TMT-based shotgun proteomics uncovers overexpression of thrombospondin 1 as a contributor in pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome - Weiqian Wang; Yan Chen; Yue Yin; Xunjiang Wang; Xuanling Ye; Kaiyuan Jiang; Yi Zhang; Jiwei Zhang; Wei Zhang; Yuzheng Zhuge; Li Chen; Chao Peng; et al. (Archives of Toxicology, 2022)
Hepatic sinusoidal obstruction disease (HSOS) is a rare but life-threatening vascular liver disease. However, its underlying mechanism and molecular changes in HSOS are largely unknown, thus greatly hindering the development of its effective treatment. Hepatic sinusoidal endothelial cells (HSECs) are the primary and essential target for HSOS. A tandem mass tag-based shotgun proteomics study was performed using primary cultured HSECs from mice with HSOS induced by senecionine, a representative toxic pyrrolizidine alkaloid (PA). Dynamic changes in proteome were found at the initial period of damage and the essential role of thrombospondin 1 (TSP1) was highlighted in PA-induced HSOS. TSP1 over-expression was further confirmed in human HSECs and liver samples from patients with PA-induced HSOS. LSKL peptide, a known TSP1 inhibitor, protected mice from senecionine-induced HSOS. In addition, TSP1 was found to be covalently modified by dehydropyrrolizidine alkaloids in human HSECs and mouse livers upon senecionine treatment, thus to form the pyrrole-protein adduct. These findings provide useful information on early changes in HSECs upon PA treatment and uncover TSP1 overexpression as a contributor in PA-induced HSOS. Graphical abstract

Microbiota profiling on itchy scalp with undetermined origin - Xuejing Li; Fang Yang; Haosong Yan; Yi Shi; Xiaowei Chang; Mengmeng Zhang; Yan Zhang; Menghui Zhang (Archives of Microbiology, 2022)

Cytotoxic tigliane diterpenoids from Euphorbia neorubella - Shuangcheng Chen; Nga Yi Tsang; Haowen Jiang; Hongjie Zhang; Xiang Ge; Yanni Wu; Yu Shen; Wenxia Xie; Jinlong Li (Natural Product Research, 2022)

Novel orthodiphenyl five-member N-heteroaromatic compounds as potent anticancer cell agents - Shijia Hu; Yunqi Li; Weiqiong Kan; Tingting Ding; Haijun Gu; Ting Zhang; Zhengfang Yi; Yihua Chen (Medicinal Chemistry Research, 2022)

Ligustilide ameliorates cognitive impairment via AMPK/SIRT1 pathway in vascular dementia rat - Dong Peng; Han-Zi Qiao; Hong-Yu Tan; Yi-Xue Wang; Dan Luo; Li-Jun Qiao; Ye-Feng Cai; Shi-Jie Zhang; Qi Wang; Li Guan (Metabolic Brain Disease, 2022)

Enhancing the stability of a global model by using an adaptively implicit vertical moist transport scheme - Jianghao Li; Yi Zhang (Meteorology and Atmospheric Physics, 2022)

De Novo SMARCC2 Variant in a Chinese Woman with Coffin-Siris Syndrome 8: a Case Report with Mild Intellectual Disability and Endocrinopathy - Sheng Yi; Mengting Li; Qi Yang; Zailong Qin; Shang Yi; Juanjuan Xu; Junjie Chen; Hao Wei; Yaoyao Jiang; Rongmin Wei; Qinle Zhang; Chengyun Yang; et al. (Journal of Molecular Neuroscience, 2022)

Application of galactinol to tomato enhances tolerance to cold and heat stresses - Yudong Liu; Li Zhang; Jian Ma; Sida Meng; Chunpeng Pang; Xiaomeng Zhao; Huidong Zhang; Shou Wang; Tao Xu; Yi He; Yufeng Liu; Mingfang Qi (Horticulture, Environment, and Biotechnology, 2022)

C2CD4A/B variants in the predisposition of lung cancer in the Chinese Han population - Feifei Han; Lu Qian; Yi Zhang; Ping Liu; Rui Li; Mingwei Chen (Functional & Integrative Genomics, 2022)

Research on fish identification in tropical waters under unconstrained environment based on transfer learning - Shan Zhang; Weifang Liu; Yupeng Zhu; Wei Han; Yi Huang; Jianqiang Li (Earth Science Informatics, 2022)
Seafloor unconstrained environment video is shot in uncontrolled open sea area. There are multiple backgrounds, complex illumination and weather changes, and rapid growth of algae and attached lenses, which affect the stability of video shooting quality, resulting in difficulty in image recognition. At present, there is still no algorithm that is superior to other methods generally, and it is necessary to build a model combined with specific scenes and applications. In this paper, a fish identification method in tropical waters based on transfer learning under unconstrained environment is proposed. Firstly, the image is pre-processed by affine transformation to realize data enhancement. Furthermore, RestNet50 deep convolutional neural network is constructed based on transfer learning to compare the effect of fish recognition before and after transfer learning. The results show that, the accuracy and loss indicators are better than those of non-transfer learning when the trained model of imagenet is introduced as the initial weight of the network. When the model is trained to 150 epochs, the indicators begin to converge, which can better complete the fish identification task in tropical waters under unconstrained environment.

Numerical Simulation of Inrush Water Spreading Through a Mine: A Case Study of the Beixinyao Mine, Shanxi Province, China - Qiang Wu; Xiaoyan Zhang; Yingwang Zhao; Peitao Li; Yi Yao; Zhili Du; Hua Xu; Xiao Wang (Mine Water and the Environment, 2022)

Parallel Extraction of Marine Targets Applying OIDA Architecture - Lin Liu; Wanwu Li; Jixian Zhang; Yi Sun; Yumeng Cui (Journal of Ocean University of China, 2022)

Genomic analysis of a recombinant coxsackievirus A19 identified in Xinxiang, China, in 2019 - Liang Yi; Li Zhang; Linlin Feng; Xubo Luan; Qian Zhao; Pengwei Xu; Yinbiao Wang; Ling Tao; Weidong Wu (Archives of Virology, 2022)

Effects of dietary protein concentration on growth and anti-oxidant capacity of coho salmon Oncorhynchus kisutch (Walbaum, 1792) alevins - Cong-mei Xu; Hai-rui Yu; Qin Zhang; Ling-yao Li; Jing-jing Fan; Meng-jie Guo; Fang-hui Li; Xiang-yi Qiu; Ling-ling Shan (Aquaculture International, 2022)

Environmental effects of mariculture in China: An overall study of nitrogen and phosphorus loads - Jihong Zhang; Wenguang Wu; Yuchen Li; Yi Liu; Xinmeng Wang (Acta Oceanologica Sinica, 2022)

Community Competition Is the Microorganism Feedback to Sedimentary Carbon Degradation Process in Aquaculture Tidal Flats - Min Zhou; Fu-Tao Fang; Cong Zeng; Li-Hong Zhang; Cheng-Xu Zhou; Zhuo-Yi Zhu (Frontiers in Marine Science, 2022)
How the microbial community response to carbon degradation is unclear, while it plays an essential role in predicting microbial community shift and determining carbon cycling. Surface sediments in two contrasting aquacultural tidal flat sites in Fujian Province, China, were collected in October, 2020. In addition to 16s rRNA gene high-throughput sequencing for determining bacteria and archaea biodiversity, an amino acids-based molecular degradation index DI was used to quantify the carbon degradation status. The results revealed that the microorganism response to DI at the family level was community competition. Specifically, the winning microbes that grew under carbon degradation (i.e., operational taxa unit numbers negatively related with the degradation index) accounted for only 18% of the total family number, but accounted for 54% of the total operational taxa unit numbers. Network analysis confirmed the oppressive relation between winners and the rest (losers + centrists), and further suggested the losers survival strategy as uniting the centrists. These findings shed new light on microorganism feedback to carbon degradation, and provide a scientific basis for the explanation of microbial community shift under progressive carbon degradation.

Tea Polyphenols Improve Down-Regulation of Mitochondrial Functional Gene Expression Induced by Bisphenol A in Zebrafish Ovaries - Xiaoxin Dai; Lijun Qiu; Han Zhang; Chunying Xu; Bo Zhao; Yang Gao; Haidong Li; Yi Mu; Zhangjie Chu (Frontiers in Marine Science, 2022)
The plasticizer bisphenol A, a typical endocrine disrupting chemical, is widely present in the environment. Previous studies demonstrated that exposure to bisphenol A can cause reproductive toxicity, abnormal fertilization, and infertility. However, the mechanisms of low-concentration bisphenol A on the reproductive system and treatment measures have not been fully determined. In this study, we explored the transcriptomic profiles of female zebrafish ovaries. The transcriptomic data revealed that mitochondrial NADH dehydrogenase (mt-Nd) genes were significantly decreased in the bisphenol A-exposed group, while the co-administration of tea polyphenols remarkably elevated the expression of mt-Nd genes. To further explore the expression pattern of the mt-Nd, we analyzed the expression of six mt-Nd genes on different days by qRT-PCR in control, bisphenol A-exposed, and bisphenol A-tea polyphenols ovaries. Here, we found that 0.1 mg/L bisphenol A exposure adversely affects the mitochondrial respiratory chain in ovaries and may lead to reproductive disorders. Finally, our study demonstrated that tea polyphenols play a protective role in ovarian mitochondrial dysfunction in low-concentration bisphenol A-exposed female zebrafish.

Numerical analysis on rock blasting damage in Xiluodu underground powerhouse using an improved constitutive model - JunHong Huang; Yi Luo; Guang Zhang; BoWen Zheng; XinPing Li; MingNan Xu; PengCheng Xu (European Journal of Environmental and Civil Engineering, 2022)

A new highly oxygenated germacranolide from Carpesium nepalense var. lanatum (C.B.Clarke) Kitam - Yi-Fan Yu; Yue-Qian Li; Ru-Yue Wang; Xu Liu; Wen-Bo Cui; Xiao-Han Chen; Cheng-Mu Zhao; Feng-Ming Qi; Zhan-Xin Zhang; Dong-Qing Fei (Natural Product Research, 2022)

ClZISO mutation leads to photosensitive flesh in watermelon - Jie Zhang; Honghe Sun; Shaogui Guo; Yi Ren; Maoying Li; Jinfang Wang; Yongtao Yu; Haiying Zhang; Guoyi Gong; Hongju He; Chao Zhang; Yong Xu (Theoretical and Applied Genetics, 2022)

Surrogate production of genome-edited sperm from a different subfamily by spermatogonial stem cell transplantation - Fenghua Zhang; Yongkang Hao; Xianmei Li; Yi Li; Ding Ye; Ru Zhang; Xiaosi Wang; Mudan He; Houpeng Wang; Zuoyan Zhu; Yonghua Sun (Science China Life Sciences, 2022)

Development and structure of four different stamens in Clematis macropetala (Ranunculaceae): particular emphasis on staminodes and staminal nectary - Wen-juan Li; Zi-xuan Huang; Meng Han; Yi Ren; Xiao-hui Zhang (Protoplasma, 2022)

Identification and characterization of stress responsive homeodomain leucine zipper transcription factors in Medicago truncatula - Xiao Li; Yiyao Hou; Fan Zhang; Mingna Li; Fengyan Yi; Junmei Kang; Qingchuan Yang; Ruicai Long (Molecular Biology Reports, 2022)

Kai-Xin-San Inhibits Tau Pathology and Neuronal Apoptosis in Aged SAMP8 Mice - Ya-Nan Jiao; Jing-Sheng Zhang; Wen-Jun Qiao; Shu-Yu Tian; Yi-Bin Wang; Chun-Yan Wang; Yan-Hui Zhang; Qi Zhang; Wen Li; Dong-Yu Min; Zhan-You Wang (Molecular Neurobiology, 2022)
Alzheimer’s disease (AD) is an age-related neurological disorder. Currently, there is no effective cure for AD due to its complexity in pathogenesis. In light of the complex pathogenesis of AD, the traditional Chinese medicine (TCM) formula Kai-Xin-San (KXS), which was used for amnesia treatment, has been proved to improve cognitive function in AD animal models. However, the active ingredients and the mechanism of KXS have not yet been clearly elucidated. In this study, network pharmacology analysis predicts that KXS yields 168 candidate compounds acting on 863 potential targets, 30 of which are associated with AD. Enrichment analysis revealed that the therapeutic mechanisms of KXS for AD are associated with the inhibition of Tau protein hyperphosphorylation, inflammation, and apoptosis. Therefore, we chose 7-month-old senescence-accelerated mouse prone 8 (SAMP8) mice as AD mouse model, which harbors the behavioral and pathological hallmarks of AD. Subsequently, the potential underlying action mechanisms of KXS on AD predicted by the network pharmacology analyses were experimentally validated in SAMP8 mice after intragastric administration of KXS for 3 months. We observed that KXS upregulated AKT phosphorylation, suppressed GSK3β and CDK5 activation, and inhibited the TLR4/MyD88/NF-κB signaling pathway to attenuate Tau hyperphosphorylation and neuroinflammation, thus suppressing neuronal apoptosis and improving the cognitive impairment of aged SAMP8 mice. Taken together, our findings reveal a multi-component and multi-target therapeutic mechanism of KXS for attenuating the progression of AD, contributing to the future development of TCM modernization, including KXS, and broader clinical application. Graphical abstract

The Effects of Ground and Treadmill Running on Energy Metabolism and Muscle Contractile Properties: A Randomized Cross-Over Study - Yuan Zhou; Jian-gang Chen; Xiao-long Li; Xin-liang Pan; Yi-zheng Zhou; Zheng-ao Li; Zhi-cheng Liang; Jia-min Long; Ming-ze Qin; Jing Zhang; Bing Shi; Bing-jun Wan; et al. (Journal of Science in Sport and Exercise, 2022)
Purpose This study aimed to compare the effects of ground and treadmill running on energy metabolism and muscle contractile properties, providing a basis for the general public to choose running venues. Methods Ten male college students (age, 20.10 ± 1.53 years; height, 176.20 ± 5.49 cm; weight, 72.14 ± 8.25 kg; body fat percent, 12.41% ± 4.65%) were recruited in this study. Energy expenditure (EE) was measured using the accelerometer (GT9X) combined with specific estimation equations. Average heart rate (HR) was measured using a heart rate band (Polar). Muscle contractile properties were assessed by measuring muscle displacement (Dm) and contraction velocity (Vc) using tensiomyography (TMG-S1). Blood glucose (Glu) and lactate (Lac) were measured by portable devices (eB-G and Lactate Scout). The running speed was 9 km/h and the duration was 25 min. Two-way ANOVA (protocol × time) was used to analyze the effect of running protocols on energy metabolism and muscle contractile properties. Results EE of treadmill running was significantly higher than EE of ground running (protocol main effect, P < 0.001), and HR of treadmill running was significantly higher than that of ground running in the first testing time (protocol simple effect, P = 0.026; protocol × time interaction P = 0.043). The decrease in Dm of the rectus femoris after treadmill running was significantly higher than that of ground running (protocol main effect, P = 0.009). The interaction of different running protocols and testing times on Lac was significant ( P = 0.025), but all results of the simple effects analysis were not statistically significant ( P > 0.05). Conclusion Our study found a difference in energy expenditure between treadmill and ground running at 9 km/h with duration of 25 min. In addition, treadmills are more likely to cause a decrease in muscle displacement distance of the rectus femoris measured after exercise than ground running. Future studies are needed to further investigate whether the differences are induced by internal metabolism or the environmental conditions of running.

Identification of PDXDC1 as a novel pleiotropic susceptibility locus shared between lumbar spine bone mineral density and birth weight - Yu-Qian Song; Shi-Di Hu; Xu Lin; Xiang-He Meng; Xiao Wang; Yin-Hua Zhang; Cheng Peng; Rui Gong; Tao Xu; Tong Zhang; Chen-Zhong Li; Dao-Yan Pan; et al. (Journal of Molecular Medicine, 2022)
An increasing number of epidemiological studies have suggested that birth weight (BW) may be a determinant of bone health later in life, although the underlying genetic mechanism remains unclear. Here, we applied a pleiotropic conditional false discovery rate (cFDR) approach to the genome-wide association study (GWAS) summary statistics for lumbar spine bone mineral density (LS BMD) and BW, aiming to identify novel susceptibility variants shared between these two traits. We detected 5 novel potential pleiotropic loci which are located at or near 7 different genes ( NTAN1 , PDXDC1 , CACNA1G , JAG1 , FAT1P1 , CCDC170 , ESR1 ), among which PDXDC1 and FAT1P1 have not previously been linked to these phenotypes. To partially validate the findings, we demonstrated that the expression of PDXDC1 was dramatically reduced in ovariectomized (OVX) mice in comparison with sham-operated (SHAM) mice in both the growth plate and trabecula bone. Furthermore, immunohistochemistry assay with serial sections showed that both osteoclasts and osteoblasts express PDXDC1 , supporting its potential role in bone metabolism. In conclusion, our study provides insights into some shared genetic mechanisms for BMD and BW as well as a novel potential therapeutic target for the prevention of OP in the early stages of the disease development. Key messages We investigated pleiotropy-informed enrichment between LS BMD and BW. We identified genetic variants related to both LS BMD and BW by utilizing a cFDR approach. PDXDC1 is a novel pleiotropic gene which may be related to both LS BMD and BW. Elevated expression of PDXDC1 is related to higher BMD and lower ratio n-6/n-3 PUFA indicating a bone protective effect of PDXDC1.

Dexmedetomidine post-conditioning alleviates myocardial ischemia–reperfusion injury in rats by ferroptosis inhibition via SLC7A11/GPX4 axis activation - Peng Yu; Jing Zhang; Yi Ding; Dandan Chen; Haijian Sun; Fenglai Yuan; Siyuan Li; Xiaozhong Li; Pingping Yang; Linghua Fu; Shuchun Yu; Jiru Zhang (Human Cell, 2022)

RhoGDI2 induced malignant phenotypes of pancreatic cancer cells via regulating Snail expression - Bin Yi; You Hu; Dongming Zhu; Jun Yao; Jian Zhou; Yi Zhang; Zhilong He; Lifeng Zhang; Zixiang Zhang; Jian Yang; Yuchen Tang; Yujie Huang; et al. (Genes & Genomics, 2022)

Correction to: Arthrobacter wenxiniae sp. nov., a novel plant growth-promoting rhizobacteria species harbouring a carotenoids biosynthetic gene cluster - Yu-chen Sun; Pengbo Sun; Jing Xue; Yunpeng Du; Hui Yan; Li-wei Wang; Xin-xin Yi; Jian-guang Sun; Xiuhai Zhang; Jun-lian Gao (Antonie van Leeuwenhoek, 2022)

Effects of Shellfish and Macro-Algae IMTA in North China on the Environment, Inorganic Carbon System, Organic Carbon System, and Sea–Air CO2 Fluxes - Yi Liu; Jihong Zhang; Wenguang Wu; Yi Zhong; Hongmei Li; Xinmeng Wang; Jun Yang; Yongyu Zhang (Frontiers in Marine Science, 2022)
Shellfish and macro-algae integrated multi-trophic aquaculture (IMTA) contribute greatly to the sustainability of aquaculture. However, the effects of large-scale shellfish and macro-algae aquaculture on the functions of the ocean carbon sink are not clear. To clarify these effects, we studied the spatial and temporal changes of inorganic and organic carbon systems in seawater under different aquaculture modes (monoculture or polyculture of shellfish and macro-algae) in Sanggou Bay, together with the variation of other environmental factors. The results show that the summertime dissolved oxygen (DO) concentration in the shellfish culture zone was significantly lower than other zones ( p < 0.05), with a minimum value of 7.07 ± 0.25 mg/L. The variation of pH and total alkalinity (TA) were large across different culture modes, and the seawater in the shellfish culture zone had the lowest pH and TA than the other zones. Seasonal environment and aquaculture modes significantly affected the variation of dissolved inorganic carbon (DIC), CO 2 partial pressure ( p CO 2 ), dissolved organic carbon (DOC), and particulate organic carbon (POC) concentrations. The highest values of DIC, p CO 2 , and POC appeared in summer, and the lowest appeared in winter. For DOC concentration, the lowest value appeared in autumn. Spatially, DIC and p CO 2 were highest in the shellfish culture zone and lowest in the macro-algae culture zone, DOC was highest in the macro-algae culture zone and lowest in the shellfish culture zone, and POC was lower in the shellfish culture zone and macro-algae culture zone and higher in the remaining zones. The results of sea–air CO 2 fluxes showed that except for the shellfish culture zone during summertime, which released CO 2 to the atmosphere, all culture zones were the sinks of atmospheric CO 2 during the culture period, with the whole bay being a strong CO 2 sink during autumn and winter. In summary, large-scale shellfish–macro-algae IMTA plays an important role in the local carbon cycle and contributes to mitigating ocean acidification and hypoxia.

Chrysomutanin and related meroterpenoids from a DES mutant of the marine-derived fungus Penicillium chrysogenum S-3-25 - Hua Qiao; Shu-Hua Zhang; Yuan Dong; Yu Yang; Rui Xu; Bo Chen; Yi Wang; Tian-Jiao Zhu; Cheng-Bin Cui; Guo-Gang Zhang; Chang-Wei Li (Natural Product Research, 2022)

A Novel Mutation in COL4A1 Gene in a Chinese Family with Pontine Autosomal Dominant Microangiopathy and Leukoencephalopathy - Qing Li; Chengfeng Wang; Wei Li; Zaiqiang Zhang; Shanshan Wang; Autongsha Wupuer; Xiao Hu; Kalibinuer Wumaier; Yi Zhu; Hongyan Li; Wengui Yu (Translational Stroke Research, 2022)
Pontine autosomal dominant microangiopathy and leukoencephalopathy (PADMAL) is a rare hereditary cerebral small vessel disease. We report a novel collagen type IV alpha 1 ( COL4A1 ) gene mutation in a Chinese family with PADMAL. The index case was followed up for 6 years. Neuroimaging, whole-exome sequencing, skin biopsy, and pedigree analysis were performed. She initially presented with minor head injury at age 38. MRI brain showed chronic lacunar infarcts in the pons, left thalamus, and right centrum semiovale. Extensive workup was unremarkable except for a patent foramen ovale (PFO). Despite anticoagulation, PFO closure, and antiplatelet therapy, the patient had recurrent lacunar infarcts in the pons and deep white matter, as well as subcortical microhemorrhages. Whole-exome sequencing demonstrated a novel c.*34G > T mutation in the 3′ untranslated region of COL4A1 gene. Skin biopsy subsequently demonstrated thickening of vascular basement membrane, proliferation of endothelial cells, and stenosis of vascular lumen. Three additional family members had gene testing and 2 of them were found to have the same heterozygous mutation. Of the 18 individuals in the pedigree of 3 generations, 12 had clinical and MRI evidence of PADMAL. The mechanisms of both ischemic and hemorrhagic stroke are likely the overexpression of COLT4A1 in the basement membrane and frugality of the vessel walls. Our findings suggest that the novel c.*34G > T mutation appears to have the same functional consequences as the previously reported COL4A1 gene mutations in patients with PADMAL and multi-infarct dementia of Swedish type.

Overexpression of a novel gene Aokap2 affects the growth and kojic acid production in Aspergillus oryzae - Yuzhen Li; Huanxin Zhang; Ziming Chen; Junxia Fan; Tianming Chen; Yi Xiao; Junyin Jie; Bin Zeng; Zhe Zhang (Molecular Biology Reports, 2022)

New ursolic acid derivatives bearing 1,2,3-triazole moieties: design, synthesis and anti-inflammatory activity in vitro and in vivo - Tian-Yi Zhang; Chun-Shi Li; Li-Ting Cao; Xue-Qian Bai; Dong-Hai Zhao; Si-Mei Sun (Molecular Diversity, 2022)

Correction to: Construction of nitrogen vacant g-C3N4 nanosheet supported Ag3PO4 nanoparticle Z-scheme photocatalyst for improved visible-light photocatalytic activity - Xiuxiu Zhang; Guiyun Yi; Peng Li; Xiaomeng Zheng; Xuhang Shen; Kunlei Ning; Lunjian Chen; Chuanxiang Zhang; Yulong Zhang; Qi Sun (Environmental Science and Pollution Research, 2022)

Arsenic in soils contaminated by arsenic-containing chemical weapons in a site of Jilin, China: fraction and bioaccessibility - Yan Zhang; Yongbing Zhu; Sanping Zhao; Daxue Li; Hailing Xi; Yi Wang (Environmental Science and Pollution Research, 2022)

Construction of nitrogen vacant g-C3N4 nanosheet supported Ag3PO4 nanoparticle Z-scheme photocatalyst for improved visible-light photocatalytic activity - Xiuxiu Zhang; Guiyun Yi; Peng Li; Xiaomeng Zheng; Xuhang Shen; Kunlei Ning; Lunjian Chen; Chuanxiang Zhang; Yulong Zhang; Qi Sun (Environmental Science and Pollution Research, 2022)

A study of health management of LWD tool based on data-driven and model-driven - Hui Li; Zi-Hua He; Yu-ting Zhang; Jin Feng; Zun-Yi Jian; Yi-Bo Jiang (Acta Geophysica, 2022)

Temperature-Induced Environmental Chain Reaction in Marine Sedimentation and Its Impact on Manila Clam Ruditapes philippinarum - Yi Liu; Jihong Zhang; Xinmeng Wang; Wenguang Wu; Qinzi Kang; Chaolun Li (Frontiers in Marine Science, 2022)
Marine Heatwaves (MHWs) events have been increasing, causing severe impacts on marine ecosystems and aquaculture. In this study, the effects of temperature on changes in sediment dissolved oxygen (DO) and hydrogen sulfide (H 2 S) concentrations and their effects on the behavioral and physiological responses of a bivalve were investigated by simulating different sudden summer temperature change conditions. The results showed that temperature was an important factor affecting DO consumption and H 2 S release in sediments, and sediment type also played a key role. At higher temperatures, DO was consumed more rapidly and H 2 S release increased in sediments, and the DO was consumed and H 2 S released in sandy sediments was less than in silty sand sediments. The response of Manila clam’s exercise behavior under environmental pressure was also rapid. The excavation index of the Manila clam decreased with the DO consumption, indicating that the Manila clam could alter its burial depth and move toward the sediment-water interface when stressed. Compared with phenol oxidases (PO) activity being activated under experimental conditions, succinate concentrations only increased slightly at 32°C, and did not surpass the threshold indicative of anaerobic metabolism. However, when toxic substances such as H 2 S start to accumulate, they may damage the immune system and tissues of the Manila clam, thereby affecting its future survival. Therefore, when temperatures are high for long periods in summer, it is necessary to take timely action to prevent and guard against harm caused by DO and H 2 S to aquaculture organisms.

How habitat heterogeneity shapes bacterial and protistan communities in temperate coastal areas near estuaries - Zelong Zhao; Hongjun Li; Yi Sun; Kuishuang Shao; Xiaocheng Wang; Xindong Ma; Anyi Hu; Haikun Zhang; Jinfeng Fan (Environmental Microbiology, 2022)
Summary In this study, we investigated microbial communities (bacteria and protist) in two coastal areas near the estuaries of the Liaohe (LH) River and Yalujiang (YLJ) River in the Northwestern Pacific Ocean. Due to the existence of Liaodong Peninsula and different levels of urbanization, geographical segregation and significant environmental heterogeneity were observed between these two areas. There were significantly different regional species pools and biogeographic patterns for both bacterial and protistan communities between LH and YLJ coastal areas. Species turnover was the main mechanism driving β‐diversity patterns of both bacterial and protistan communities in each area. In addition, the contributed ratio of nestedness to the β‐diversity patterns was significantly higher for protists compared to bacteria. Variation in regional species pools was found to be the dominant driver of differences of bacterial and protistan communities between the LH and YLJ coastal areas. For a single‐studied area, local community assembly mechanisms, including heterogeneous selection and dispersal limitation, were found to shape the bacterial and protistan communities through calculation of the β‐deviation index. Among them, the relative importance of heterogeneous selection and dispersal limitation on the community assembly varied according to microorganism type and habitat.

Decadal shift of the influence of Arctic Oscillation on dust weather frequency in spring over the Middle East during 1974–2019 - Yijie Sun; Rui Mao; Dao‐Yi Gong; Ying Li; Seong‐Joong Kim; Xiao‐Xiao Zhang; Xuezhen Zhang; Mehdi Hamidi (International Journal of Climatology, 2022)
Dust weather has an impact on human health and climate change in the Middle East. In this study, we examined the influence of the Arctic Oscillation (AO) on spring dust weather frequency over the Middle East at an interannual timescale during 1974–2019. The results show that there was an interdecadal shift of the influence of AO on dust weather frequency in the Middle East, with a correlation coefficient between the AO index and dust weather frequency changing from −0.52 during 1974–1994 period (P1) to 0.49 during 1995–2013 period (P2). During P1, negative correlations between AO index and dust weather frequency were found over the northern Arabian Peninsula, and during P2, positive ones were mostly over the central and southwestern Arabian Peninsula. In the lower and middle troposphere, negative geopotential height anomalies are associated with the negative phase of the AO over South Europe during P1, whereas negative geopotential height anomalies are associated with the positive phase of the AO over Northeast Africa during P2. The negative height anomalies resulted in the occurrence of more low‐pressure systems and, thus, dust weather in the Middle East. It is found that the interdecadal shift of the influence of the AO on dust weather was related to an AO‐related northward displacement of wave train propagation during P2. Specifically, during P1 period, the northern branch of AO‐related wave train dominated over the middle latitudes of the North Atlantic across South Europe to the Arabian Peninsula, which resulted in the negative height anomaly over South Europe in the lower and middle troposphere. However, during P2 period, the AO‐related wave train propagation moved northward, and then, the southern branch of the AO‐related wave train dominated over the low latitudes of the North Atlantic across northern Africa to the Arabian Peninsula, which played an important role in the formation of the negative height anomalies over Northeast Africa.

Microplastic Contamination on the Beaches of South China - Bingwen Chai; Yanping Li; Li Wang; Xiao-Tan Zhang; Yi-Ping Wan; Fengyuan Chen; Jie Ma; Wenlu Lan; Ke Pan (Frontiers in Marine Science, 2022)
Microplastics (MPs) have emerged as a pollutant of significant global concern. The sandy beach is a fragile environment that deserves our special attention with regard to MP contamination, as this area is a hotspot that accumulates large quantities of plastic waste. Notably, our current understanding of the MP distribution on beaches and the scale of contamination is far from sufficient. Hence, this study investigated the occurrence and characteristics of MPs on 14 beaches along the coast of South China. The MPs were ubiquitously distributed in the sand, most were small, less than 1 mm. A total of 18 types of polymers were identified in the sand, suggesting that diverse types of MPs are present on the beaches. Polyethylene, polypropylene, and polystyrene were the dominant types of MPs in most of our sampling sites. The MP abundance was higher in the upper layers (0–20 cm) of the beach than in the deeper layers (20–40 cm) of the sampling site when characterized by depth (Yangjiang beach). Our study demonstrates the extent and severity of MP pollution on the beaches of South China and provides implications for future remediation measures. More effort is needed to clarify the vertical distribution of MPs on beaches, especially for those MPs less than 1 μm.

Sterols and triterpenoids from Ganoderma lucidum and their reversal activities of tumor multidrug resistance - Min Wu; Cui-e Shen; Qiao-fa Lin; Jin-yi Zhong; Yan-fei Zhou; Ben-chen Liu; Jian-hua Xu; Zhi-qiang Zhang; Peng Li (Natural Product Research, 2022)

Two new sesquiterpenes from the rhizomes of Atractylodes macrocephala and their biological activities - Yi-Nan Zhao; Gai Gao; Jin-Lian Ma; Rui-Zhu Xu; Tao Guo; Li-Min Wu; Xin-Guang Liu; Zhi-Shen Xie; Jiang-Yan Xu; Zhen-Qiang Zhang; Pan Wang (Natural Product Research, 2022)

New sesquiterpeniod esters form Blumea balsamifera (L.) DC. and their anti-influenza virus activity - Yan Xiong; Ping Yi; Yuhuan Li; Rongmei Gao; Junlei Chen; Zhanxing Hu; Huayong Lou; Caixia Du; Jiayu Zhang; Yu Zhang; Chunmao Yuan; Liejun Huang; et al. (Natural Product Research, 2022)

Comparison of the Variability of Small Extracellular Vesicles Derived from Human Liver Cancer Tissues and Cultured from the Tissue Explants Based on a Simple Enrichment Method - Jie Chen; Zhigang Jiao; Jianwen Mo; Defa Huang; Zhengzhe Li; Wenjuan Zhang; Tong Yang; Minghong Zhao; Fangfang Xie; Die Hu; Xiaoxing Wang; Xiaomei Yi; et al. (Stem Cell Reviews and Reports, 2022)
A potential use of small extracellular vesicles (sEVs) for diagnostic and therapeutic purposes has recently generated a great interest. sEVs, when purified directly from various tissues with proper procedures, can reflect the physiological and pathological state of the organism. However, the quality of sEV is affected by many factors during isolation, including separation of sEV from cell and tissues debris, the use of enzymes for tissue digestion, and the storage state of tissues. In the present study, we established an assay for the isolation and purification of liver cancer tissues-derived sEVs (tdsEVs) and cultured explants-derived sEVs (cedsEVs) by comparing the quality of sEVs derived from different concentration of digestion enzyme and incubation time. The nano-flow cytometry (NanoFCM) showed that the isolated tdsEVs by our method are purer than those obtained from differential ultracentrifugation. Our study thus establishes a simple and effective approach for isolation of high-quality sEVs that can be used for analysis of their constituents. Graphical abstract

Functional characterization of tyrosine decarboxylase genes that contribute to acteoside biosynthesis in Rehmannia glutinosa - Yan Hui Yang; Mu Rong Yang; Jian Yu Zhu; Ke Wei Dong; Yan Jie Yi; Rui Fang Li; Lei Zeng; Chang Fu Zhang (Planta, 2022)

Transcriptomic analyses reveal the effect of nitric oxide on the lateral root development and growth of mangrove plant Kandelia obovata - Ming-Yue Wei; Huan Li; You-Hui Zhong; Zhi-Jun Shen; Dong-Na Ma; Chang-Hao Gao; Yi-Ling Liu; Wen-Hua Wang; Jing-Ya Zhang; Yan-Ping You; Hai-Lei Zheng (Plant and Soil, 2022)

Associations of CXCL12 polymorphisms with clinicopathological features in breast cancer: a case-control study - Shuai Lin; Yi Zheng; Meng Wang; Linghui Zhou; Yuyao Zhu; Yujiao Deng; Ying Wu; Dai Zhang; Na Li; Huafeng Kang; Zhijun Dai (Molecular Biology Reports, 2022)
Background Previous studies suggested that CXCL12 was involved in the development, metastasis, and invasion of breast cancer, and genetic variants were associated with the diagnosis and prognosis of patients with breast cancer. The present study was aimed to assess the relationships between CXCL12 polymorphisms (rs1801157, rs2297630, and rs2839693) and susceptibility and clinicopathological features of breast cancer. Methods A case-control study was conducted in 434 breast cancer patients and 450 health controls. Student t -test and chi-square test were used to analyze the differences of age distribution and genotype frequencies between the two groups. Correlations between polymorphisms and clinical parameters were also assessed by chi-square test. The potential effects of the three polymorphisms on CXCL12 were investigated by the public database. Results A statistical association was found between CXCL12 rs1801157 polymorphism and breast cancer risk, possibility of metastasis, and estrogen receptor status. Patients with rs2839693 C/T or C/T-T/T genotypes were more likely to be progesterone receptor-negative. However, no associations of rs2297630 polymorphism with breast cancer risk or any clinicopathological characteristics were observed. In addition, rs2297630 affected the splicing quantitative trait loci of CXCL12 in the subcutaneous fat, rs2839693 polymorphism affected the splicing quantitative trait loci of CXCL12 in the human breast mammary tissues. Conclusions Those results indicated that CXCL12 polymorphisms might be potential diagnostic indicators, and more investigation is needed in the future.

Simulation of potential suitable distribution of original species of Fritillariae Cirrhosae Bulbus in China under climate change scenarios - Lei Liu; Yuanyuan Zhang; Yi Huang; Jindong Zhang; Qiuyu Mou; Jianyue Qiu; Rulin Wang; Yujie Li; Dequan Zhang (Environmental Science and Pollution Research, 2022)

Identification of epigenetic modifications mediating the antagonistic effect of selenium against cadmium-induced breast carcinogenesis - Zhuo-Zhi Liang; Yi-Xin Zhang; Rui-Mei Zhu; Yue-Lin Li; Hong-Mei Jiang; Ruo-Bi Li; Qian-Xin Chen; Qing Wang; Lu-Ying Tang; Ze-Fang Ren (Environmental Science and Pollution Research, 2022)

Corrigendum: Pigmentibacter ruber gen. nov., sp. nov., a novel bacterium of the family Silvanigrellaceae isolated from human blood - Na Peng; Wen Xu; Hai-Min Luo; Peng-Wen Ouyang; Bin Jiang; Zhi-Hua Zhang; You-De Cao; Li-Ming Tan; Ping-Hua Qu; Liang-Yi Xie (Antonie van Leeuwenhoek, 2022)

Arthrobacter wenxiniae sp. nov., a novel plant growth-promoting rhizobacteria species harbouring a carotenoids biosynthetic gene cluster - Yu-chen Sun; Pengbo Sun; Jing Xue; Yunpeng Du; Hui Yan; Li-wei Wang; Xin-xin Yi; Jian-guang Sun; Xiuhai Zhang; Jun-lian Gao (Antonie van Leeuwenhoek, 2022)

A novel inverse transformation algorithm for pushbroom TDI CCD imaging - Yonghua Jiang; Guo Zhang; Litao Li; Ziqiang Tan; Zhongxing Tang; Yi Xu (International Journal of Remote Sensing, 2022)

The Relationship of Morphological-Hemodynamic Characteristics, Inflammation, and Remodeling of Aneurysm Wall in Unruptured Intracranial Aneurysms - Qingyuan Liu; Yisen Zhang; Junhua Yang; Yi Yang; Maogui Li; Shanwen Chen; Pengjun Jiang; Nuochuan Wang; Yanan Zhang; Jia Liu; Jun Wu; Shuo Wang (Translational Stroke Research, 2022)

Plant-derived lignans as potential antiviral agents: a systematic review - Xin-Ya Xu; Dong-Ying Wang; Yi-Ping Li; Stephen T. Deyrup; Hong-Jie Zhang (Phytochemistry Reviews, 2022)

Litter nitrogen concentration changes mediate effects of drought and plant species richness on litter decomposition - Jiang Wang; Yuan Ge; Johannes H. C. Cornelissen; Xiao-Yan Wang; Song Gao; Yi Bai; Tong Chen; Zhong-Wang Jing; Chong-Bang Zhang; Wen-Li Liu; Jun-Min Li; Fei-Hai Yu (Oecologia, 2022)

Synthesis and evaluation of ursolic acid-based 1,2,4-triazolo[1,5-a]pyrimidines derivatives as anti-inflammatory agents - Tian-Yi Zhang; Chun-Shi Li; Ping Li; Xue-Qian Bai; Shu-Ying Guo; Ying Jin; Sheng-Jun Piao (Molecular Diversity, 2022)

Chemerin promotes proliferation and migration of ovarian cancer cells by upregulating expression of PD-L1 - Chenxi Gao; Jinming Shi; Jingxin Zhang; Yin Li; Yi Zhang (Journal of Zhejiang University-SCIENCE B, 2022)

Transgelin-2 interacts with CD44 to regulate Notch1 signaling pathway and participates in colorectal cancer proliferation and migration - Rong Ding; Guoyu Li; Yueyi Yao; Lijuan Zhang; Xuan Zhang; Jiayi Li; Tao Shen; Yi Gao; Tao Wu; Shuzhen Kong; Ming Huang; Yunfeng Li (Journal of Physiology and Biochemistry, 2022)

Oxidative degradation/mineralization of dimethyl phthalate (DMP) from plastic industrial wastewater using ferrate(VI)/TiO2 under ultraviolet irradiation - Ping Wang; Yi Ding; Liting Zhu; Yunhao Zhang; Sijie Zhou; Linbei Xie; Ao Li (Environmental Science and Pollution Research, 2022)

Effects of exposure to fine particulate matter on the decline of lung function in rural areas in northwestern China - Di Tian; Xiyuan Chen; Pengyi Hou; Yi Zhao; Yu Zhao; Yajuan Zhang; Jiangping Li; Yuhong Zhang; Faxuan Wang (Environmental Science and Pollution Research, 2022)

The association between short-term ambient air pollution and acne vulgaris outpatient visits: a hospital-based time-series analysis in Xi’an - Xiang Li; Yi Cao; Shu-Jie An; Ying Xiang; He-Xiang Huang; Bin Xu; Yao Zhang; Ya-Fei Li; Yuan-Gang Lu; Tong-Jian Cai (Environmental Science and Pollution Research, 2022)

A survey of brain network analysis by electroencephalographic signals - Cuihua Luo; Fali Li; Peiyang Li; Chanlin Yi; Chunbo Li; Qin Tao; Xiabing Zhang; Yajing Si; Dezhong Yao; Gang Yin; Pengyun Song; Huazhang Wang; et al. (Cognitive Neurodynamics, 2022)

A Hydroponic Study on Effect of Zinc Against Mercury Uptake by Triticale: Kinetic Process and Accumulation - Ting Liu; Yi Man; Ping Li; Hua Zhang; Huangxin Cheng (Bulletin of Environmental Contamination and Toxicology, 2022)

Electroacupuncture enhances resting-state functional connectivity between dorsal caudate and precuneus and decreases associated leptin levels in overweight/obese subjects - Yang He; Karen M. von Deneen; Guanya Li; Borong Jing; Yanyan Zhou; Kaiya Zhang; Yi Zhang; Yuanyuan Ren (Brain Imaging and Behavior, 2022)

Characterization and Expression Analyses of Callose Synthase Enzyme (Cals) Family Genes in Maize (Zea mays L.) - Qunkai Niu; Peng Zhang; Shuai Su; Bin Jiang; Xiaowei Liu; Chuan Li; Tao Yu; Hongyang Yi; Jin Tang; Moju Cao (Biochemical Genetics, 2022)

miR-181b-5p Promotes the Progression of Cholangiocarcinoma by Targeting PARK2 via PTEN/PI3K/AKT Signaling Pathway - Zhe-Long Jiang; Fu-Xing Zhang; Hong-Liang Zhan; He-Jun Yang; Si-Yu Zhang; Zhao-Hui Liu; Yi Jiang; Li-Zhi Lv; Rui-Sheng Ke (Biochemical Genetics, 2022)

Geographic latitude and human height - Statistical analysis and case studies from China - Guoguang Lu; Yi Hu; Zhihui Yang; Yan Zhang; Shengxu Lu; Siyuan Gong; Tingting Li; Yijie Shen; Sihan Zhang; Hanya Zhuang (Arabian Journal of Geosciences, 2022)
Based on Chinese General Social Survey(CGSS) data, this paper selects ten variables, including height, gender, household registration, and age. Through the statistical analysis of 57,574 survey samples, this study finds that the average height of China’s population has increased by more than 10 cm in the past 100 years. Among the findings, the data indicate the average height of men born after the 1990s is 11 cm taller than that of men born after the 1920s, which has now reached 173 cm, and that the height of women is 10.93 cm taller, averaging 163 cm. The average height of the Chinese population reflects significant differences in gender, region or province, urbanity and rurality, and nationality, among other variables. The average height of men and women gradually increases with the increase of geographical latitude. Some economically developed southern provinces approach the average height of the North. This paper predicts that the average height of the newborn population will continue to have inertial growth in the next 20 years, and the newborn male population will reach the World Health Organization’s ideal height standard of 176.5 cm by 2030. The analysis suggests that geographic latitude and heredity are the determinants of body development. Geographical latitude difference is a super-variable for human mitochondria to regulate the proportion of heat outflow and ATP transformation. Historically, the population living in high-latitude areas of China migrates to economically developed low-latitude provinces such as Shanghai, Jiangsu, Zhejiang, and Guangdong, which is the main reason why the per capita height in these areas is significantly taller than that in other southern provinces.

A new nudging scheme for the current operational climate prediction system of the National Marine Environmental Forecasting Center of China - Xunshu Song; Xiaojing Li; Shouwen Zhang; Yi Li; Xinrong Chen; Youmin Tang; Dake Chen (Acta Oceanologica Sinica, 2022)

Oxidation of organoarsenicals and antimonite by a novel flavin monooxygenase widely present in soil bacteria - Jun Zhang; Jian Chen; Yi‐Fei Wu; Zi‐Ping Wang; Ji‐Guo Qiu; Xiao‐Long Li; Feng Cai; Ke‐Qing Xiao; Xiao‐Xu Sun; Barry P. Rosen; Fang‐Jie Zhao (Environmental Microbiology, 2022)
Summary Arsenic can be biomethylated to form a variety of organic arsenicals differing in toxicity and environmental mobility. Trivalent methylarsenite (MAs(III)) produced in the methylation process is more toxic than inorganic arsenite (As(III)). MAs(III) also serves as a primitive antibiotic and, consequently, some environmental microorganisms have evolved mechanisms to detoxify MAs(III). However, the mechanisms of MAs(III) detoxification are not well understood. In this study, we identified an arsenic resistance ( ars ) operon consisting of three genes, arsRVK , that contribute to MAs(III) resistance in Ensifer adhaerens ST2. ArsV is annotated as an NADPH‐dependent flavin monooxygenase with unknown function. Expression of arsV in the arsenic hypersensitive Escherichia coli strain AW3110 Δars conferred resistance to MAs(III) and the ability to oxidize MAs(III) to MAs(V). In the presence of NADPH and either FAD or FMN, purified ArsV protein was able to oxidize both MAs(III) to MAs(V) and Sb(III) to Sb(V). Genes with arsV ‐like sequences are widely present in soils and environmental bacteria. Metagenomic analysis of five paddy soils showed the abundance of arsV ‐like sequences of 0.12–0.25 ppm. These results demonstrate that ArsV is a novel enzyme for the detoxification of MAs(III) and Sb(III) and the genes encoding ArsV are widely present in soil bacteria.

MF-Dfnet: a deep learning method for pixel-wise classification of very high-resolution remote sensing images - Shichao Zhang; Changying Wang; Jinhua Li; Yi Sui (International Journal of Remote Sensing, 2022)

Cloning and functional analysis of soluble acid invertase 2 gene (SbSAI-2) in sorghum - Wuyuntanmanda; Fen-Xia Han; Bao-Qing Dun; Ji Zhang; Zhi Wang; Yi Sui; Li Zhu; Gui-Ying Li (Planta, 2022)

Sugar transporter VST1 knockout reduced aphid damage in watermelon - Maoying Li; Shaogui Guo; Jie Zhang; Honghe Sun; Shouwei Tian; Jinfang Wang; Yi Zuo; Yongtao Yu; Guoyi Gong; Haiying Zhang; Yi Ren; Yong Xu (Plant Cell Reports, 2022)

β-Catenin Deletion in Regional Neural Progenitors Leads to Congenital Hydrocephalus in Mice - Lin Ma; Yanhua Du; Xiangjie Xu; Hexi Feng; Yi Hui; Nan Li; Guanyu Jiang; Xiaoqing Zhang; Xiaocui Li; Ling Liu (Neuroscience Bulletin, 2022)

A community effort to assess and improve computerized interpretation of 12-lead resting electrocardiogram - Zijian Ding; Guijin Wang; Huazhong Yang; Ping Zhang; Dapeng Fu; Zhen Yang; Xinkang Wang; Xia Wang; Zhourui Xia; Chiming Zhang; Wenjie Cai; Binhang Yuan; et al. (Medical & Biological Engineering & Computing, 2022)
Computerized interpretation of electrocardiogram plays an important role in daily cardiovascular healthcare. However, inaccurate interpretations lead to misdiagnoses and delay proper treatments. In this work, we built a high-quality Chinese 12-lead resting electrocardiogram dataset with 15,357 records, and called for a community effort to improve the performances of CIE through the China ECG AI Contest 2019. This dataset covers most types of ECG interpretations, including the normal type, 8 common abnormal types, and the other type which includes both uncommon abnormal and noise signals. Based on the Contest, we systematically assessed and analyzed a set of top-performing methods, most of which are deep neural networks, with both their commonalities and characteristics. This study establishes the benchmarks for computerized interpretation of 12-lead resting electrocardiogram and provides insights for the development of new methods.

Characterization of pre-failure deformation and evolution of a large earthflow using InSAR monitoring and optical image interpretation - Zhang Yi; Meng Xingmin; Novellino Allesandro; Dijkstra Tom; Chen Guan; Jordan Colm; Li Yuanxi; Su Xiaojun (Landslides, 2022)

LED Light Quality Affect Growth, Alkaloids Contents, and Expressions of Amaryllidaceae Alkaloids Biosynthetic Pathway Genes in Lycoris longituba - Qingzhu Li; Junxu Xu; Liuyan Yang; Yi Sun; Xiaohui Zhou; Yuhong Zheng; Yongchun Zhang; Youming Cai (Journal of Plant Growth Regulation, 2022)

A Novel De Novo TUBB3 Variant Causing Developmental Delay, Epilepsy and Mild Ophthalmological Symptoms in a Chinese Child - Jiao Xue; Zhenfeng Song; Shuyin Ma; Zhi Yi; Chengqing Yang; Fei Li; Kaixuan Liu; Ying Zhang (Journal of Molecular Neuroscience, 2022)

HMGB1-RAGE Pathway Contributes to the Abnormal Migration of Endogenous Subventricular Zone Neural Progenitors in an Experimental Model of Focal Microgyria - Yi-Wen Mei; Tian-Lan Huang; Xin Chen; Si-Xun Yu; Jie Li; Zhi Zhang; Yang He; Da-qing Guo; Hai-Feng Shu (Journal of Molecular Neuroscience, 2022)

Retraction Note to: Revisiting the male genetic landscape of China: a multi-center study of almost 38,000 Y-STR haplotypes - Michael Nothnagel; Guangyao Fan; Fei Guo; Yongfeng He; Yiping Hou; Shengping Hu; Jiang Huang; Xianhua Jiang; Wook Kim; Kicheol Kim; Chengtao Li; Hui Li; et al. (Human Genetics, 2022)

Research on the Surrounding Rock Control Technology of Gob-Side Entry with a Narrow Coal Pillar Reserved in a Fully Mechanized Caving Face with Large Mining Height - Yi Wang; Yingming Li; Zhonglin Yu; Hao Zhang; Dan Ding (Geotechnical and Geological Engineering, 2022)

Spatiotemporal evolutionary analysis of rainfall erosivity during 1901–2017 in Beijing, China - Yanlin Li; Yi He; Yaru Zhang; Liping Jia (Environmental Science and Pollution Research, 2022)

Effect of high temperature on pore characteristics, yield stress, and deformation property of sandstone - Weiqiang Zhang; Zuoquan Wang; Yi Du; Shaoteng Zhang; Zhoujian Shi; Fanjia Li (Bulletin of Engineering Geology and the Environment, 2022)

Correction to: Multilineage differentiation of muscle-derived stem cells from GFP transgenic mice - Chuan Ye; Jiangwei Li; Zixu He; Xu Nin; Yi Zhang; Xianwen Shang; Riguang Liu; Yiqiang Duan (Biotechnology Letters, 2022)

Assessment of landslide susceptibility using DBSCAN-AHD and LD-EV methods - Yi-min Mao; Deborah S. Mwakapesa; Yi-can Li; Kai-bin Xu; Yaser A. Nanehkaran; Mao-sheng Zhang (Journal of Mountain Science, 2022)

Human bocavirus 2 detected in Rattus norvegicus feces in China - Fang-Fei You; Min-Yi Zhang; Fei Wu; Qiu-Shuang Li; Qing Chen (Archives of Virology, 2022)

Alteribacter salitolerans sp. nov., isolated from a saline-alkaline soil - Shuang Wang; Lei Sun; Manik Prabhu Narsing Rao; Guo-Hong Liu; Pin-Jiao Jin; Zhou-Yan Dong; Zheng-Han Lian; Xiao-Yu Hao; Ming-Yi Zhang; Wen-Jun Li (Archives of Microbiology, 2022)

Transcriptome analysis of potential flocculation-related genes in Streptomyces sp. hsn06 with flocculation activity on Chlorella vulgaris biomass - Yi Li; Muyuan Ma; Ruxian Jing; Zhiyu Zhang; Xiaobing Jiang; Hailei Wang (Archives of Microbiology, 2022)

Study on nanopore structure of soil and quantitative characterization based on mercury intrusion, liquid nitrogen adsorption, CO2 adsorption, and SEM - Xiangchun Li; Mengya Wang; Shuang Zhang; Wenyu Yan; Dengyu Xu; Yi Li; Yukun Fu; Chunli Yang; Lei Xie; Weidong Lu (Arabian Journal of Geosciences, 2022)

Biogeography of culturable marine bacteria from both poles reveals that ‘everything is not everywhere’ at the genomic level - Qi‐Long Qin; Zhi‐Bin Wang; Qian‐Qian Cha; Sha‐Sha Liu; Xue‐Bing Ren; Hui‐Hui Fu; Mei‐Ling Sun; Dian‐Li Zhao; Andrew McMinn; Yin Chen; Xiu‐Lan Chen; Yu‐Zhong Zhang; et al. (Environmental Microbiology, 2022)
Summary Based on 16S rRNA gene analyses, the same bacterial operational taxonomic units (OTUs) are common to both the Arctic and Antarctic oceans, supporting the concept ‘everything is everywhere’. However, whether the same OTUs from both poles have identical genomes, i.e. whether ‘everything is still everywhere’ at the genomic level has not yet been examined systematically. Here, we isolated, sequenced and compared the genomes of 45 culturable marine bacteria belonging to three genera of Salinibacterium , Psychrobacter and Pseudoalteromonas from both polar oceans. The bacterial strains with identical 16S rRNA genes were common to both poles in every genus, and four identical genomes were detected in the genus Salinibacterium from the Arctic region. However, no identical genomes were observed from opposite poles in this study. Our data, therefore, suggest that ‘everything is not everywhere’ at the genomic level. The divergence time between bacteria is hypothesized to exert a strong impact on the bacterial biogeography at the genomic level. The geographical isolation between poles was observed for recently diverged, highly similar genomes, but not for moderately similar genomes. This study thus improves our understanding of the factors affecting the genomic‐level biogeography of marine microorganisms isolated from distant locations.

Angiogenic effects of low molecular weight organic acids present in fulvic acids of different sources - Zhi Wang; Huifen Zhang; Yi Qin; Weifeng Dai; Baocai Li; Mi Zhang (Natural Product Research, 2021)

The in vitro and in vivo anti-inflammatory activities of triterpene saponins from Clematis florida - Na-Na Yang; Yi-Fan Zhang; Hai-Tao Zhang; Xin-Hua Ma; Jin-Huang Shen; Peng Li; Tian-Hua Zhong; Yong-Hong Zhang (Natural Product Research, 2021)