Review of the regional nomenclature and tectonic setting for mesozoic gold deposits in the Malanyu Anticline area of Eastern Hebei Province, North China - Leon Bagas; Frank Bierlein; Si-Hong Jiang; Yi-Fei Liu; Li-Li Zhang (International Geology Review, 2021)

Hyperprzeone A, a new benzophenone with cytotoxicity from Hypericum przewalskii Maxim - Yi Zhang; Yue Yang; Qian Chen; Ning Li (Natural Product Research, 2021)

The Key Regulator of Necroptosis, RIP1 Kinase, Contributes to the Formation of Astrogliosis and Glial Scar in Ischemic Stroke - Yong-Ming Zhu; Liang Lin; Chao Wei; Yi Guo; Yuan Qin; Zhong-Sheng Li; Thomas A. Kent; Claire E. McCoy; Zhan-Xiang Wang; Yong Ni; Xian-Yong Zhou; Hui-Ling Zhang (Translational Stroke Research, 2021)
Necroptosis initiation relies on the receptor-interacting protein 1 kinase (RIP1K). We recently reported that genetic and pharmacological inhibition of RIP1K produces protection against ischemic stroke-induced astrocytic injury. However, the role of RIP1K in ischemic stroke-induced formation of astrogliosis and glial scar remains unknown. Here, in a transient middle cerebral artery occlusion (tMCAO) rat model and an oxygen and glucose deprivation and reoxygenation (OGD/Re)-induced astrocytic injury model, we show that RIP1K was significantly elevated in the reactive astrocytes. Knockdown of RIP1K or delayed administration of RIP1K inhibitor Nec-1 down-regulated the glial scar markers, improved ischemic stroke-induced necrotic morphology and neurologic deficits, and reduced the volume of brain atrophy. Moreover, knockdown of RIP1K attenuated astrocytic cell death and proliferation and promoted neuronal axonal generation in a neuron and astrocyte co-culture system. Both vascular endothelial growth factor D (VEGF-D) and its receptor VEGFR-3 were elevated in the reactive astrocytes; simultaneously, VEGF-D was increased in the medium of astrocytes exposed to OGD/Re. Knockdown of RIP1K down-regulated VEGF-D gene and protein levels in the reactive astrocytes. Treatment with 400 ng/ml recombinant VEGF-D induced the formation of glial scar; conversely, the inhibitor of VEGFR-3 suppressed OGD/Re-induced glial scar formation. RIP3K and MLKL may be involved in glial scar formation. Taken together, these results suggest that RIP1K participates in the formation of astrogliosis and glial scar via impairment of normal astrocyte responses and enhancing the astrocytic VEGF-D/VEGFR-3 signaling pathways. Inhibition of RIP1K promotes the brain functional recovery partially via suppressing the formation of astrogliosis and glial scar. Graphical Abstract

Variability of extreme precipitation and rainfall erosivity and their attenuated effects on sediment delivery from 1957 to 2018 on the Chinese Loess Plateau - Xiaoming Xu; Du Lyu; Xiangjie Lei; Tao Huang; Yali Li; Haijie Yi; Jinwei Guo; Liang He; Jie He; Xihua Yang; Mancai Guo; Baoyuan Liu; et al. (Journal of Soils and Sediments, 2021)

Overexpression of the PLK4 Gene as a Novel Strategy for the Treatment of Autosomal Recessive Microcephaly by Improving Centrosomal Dysfunction - Ya-Song Xu; Zhi-Ying Su; Li Sun; Xiao-Mei Yang; Shi-Yu Sun; Xiao-Fei Ji; Yi-Zhen Ji; Su-Qing Zhang; Jie Tian; Qi-Chang Wu (Journal of Molecular Neuroscience, 2021)

Correction to: Synthesis and evaluation of iridium(III) complexes on antineoplastic activity against human gastric carcinoma SGC‑7901 cells - Li Tian; Yuanyuan Zhang; Huiwen Zhang; Yi Zhou; Wenlong Li; Yuhan Yuan; Jing Hao; Linlin Yang; Yunjun Liu (JBIC Journal of Biological Inorganic Chemistry, 2021)

Expression and Characterization of a Potent Long-Acting GLP-1 Receptor Like Agonist, Exendin-4-Fc - Wen Zhang; Ming Li; Yanlu Zan; Yi Bai (International Journal of Peptide Research and Therapeutics, 2021)
Human GLP-1 (glucagon-like peptide-1) can produce a remarkable improvement in glycemic control in patients with type 2 diabetes. However, its clinical benefits are limited by its short half-life, which is less than 2 min because of its small size and rapid enzymatic inactivation by dipeptidyl peptidase IV. We engineered Exendin-4-Fc, a 66-kDa fusion protein by linking an IgG2 Fc to Exendin-4. A stably transfected Chinese hamster ovary cell line was obtained using electroporation. Exendin-4-Fc stimulated insulin secretion in INS-1 cells in a dose- and glucose-dependent manner and increased insulin mRNA expression. The plasma half-life of Exendin-4-Fc in cynomolgus monkeys was approximately 133.92 ± 25.1 h. In the KKAy mouse model of diabetes, one intraperitoneal injection of Exendin-4-Fc (1 mg/kg) reduced blood glucose levels for 5 days. A 4-week repeat-administration study identified sustained effects on blood glucose levels. Oral glucose tolerance tests conducted at the beginning and end of this 4-week period showed that Exendin-4-Fc produced a stable glucose lowering effect. In addition, KKAy mice treated with Exendin-4-Fc showed statistically significant weight loss from day 23. In conclusion, these properties of Exendin-4-Fc demonstrated that it could be a potential long-acting GLP-1 receptor agonist for the treatment of type 2 diabetes.

Forest Fragmentation Slows the Decomposition of Coarse Woody Debris in a Subtropical Forest - Chunsheng Wu; Chunjie Shu; Zhijian Zhang; Yanyan Li; Yi Zhang; Yuanqiu Liu (Forest Science, 2021)
Forest fragmentation is increasing rapidly around the world, and edge effects caused by fragmented forests can influence ecosystem functions and ecological processes, including coarse woody debris (CWD) decomposition. Understanding the influencing mechanisms of edge effect on CWD decomposition is needed to assess the effects of forest fragmentation on carbon cycling and storage. We measured rates of mass loss of CWD of Cinnamomum camphora (L.) Presl. and Pinus taiwanensis Hayata over two years at two distances (0−5 m versus 60 m) from a forest edge at two altitudes (215 and 1,400 m a.s.l.), in a subtropical forest. In addition, we determined the microbial community of each CWD segment and the soil beneath via phospholipid fatty acids (PLFAs). Mass loss of CWD 60 m from the forest edge was 15% greater than that at the edge (0–5 m). Mass loss was positively correlated with the abundance of microbial and fauna community and moisture content of the decaying CWD. Distance from edge explained 17.4% of the total variation of the microbial abundance in CWD. The results indicate that the reduced abundance of microbial and fauna communities and moisture content at forest edges influenced rates of decomposition of CWD. Long-term experiments with more tree species and more forest types are needed to better assess edge effects generally.

Correction to: Enhanced adsorption of phosphorus in soil by lanthanum-modified biochar: improving phosphorus retention and storage capacity - Di Zhao; Yuan Luo; Yi-yang Feng; Qiu-ping He; Li-sheng Zhang; Ke-qiang Zhang; Feng Wang (Environmental Science and Pollution Research, 2021)

Treatment of the actual landfill leachate in different constructed wetlands through intermittent and varied aeration mode - Yi Wang; Wen-Huai Wang; Heng Zhang; Fei-Long Yan; Jia-Jun Li (Environmental Science and Pollution Research, 2021)

Enhanced adsorption of phosphorus in soil by lanthanum-modified biochar: improving phosphorus retention and storage capacity - Di Zhao; Yuan Luo; Yi-yang Feng; Qiu-ping He; Li-sheng Zhang; Ke-qiang Zhang; Feng Wang (Environmental Science and Pollution Research, 2021)

Emission Reduction Efficiency Analysis Based on Characteristics of Vehicle Emissions - Yi Xu; Yujiao Hao; Tongqing Zhang; Wei Yan; Yuqiong Wang; Dong Guo; Xiaochuan Tan; Xingbang Gao; Jiaojiao Li (Emission Control Science and Technology, 2021)

Astaxanthin Ameliorates Blood Pressure in Salt-Induced Prehypertensive Rats Through ROS/MAPK/NF-κB Pathways in the Hypothalamic Paraventricular Nucleus - Hong-Li Gao; Xiao-Jing Yu; Yan Zhang; Chen-Long Wang; Yi-Ming Lei; Jia-Yue Yu; Dong-Miao Zong; Kai-Li Liu; Dong-Dong Zhang; Ying Li; Hua Tian; Nian-Ping Zhang; et al. (Cardiovascular Toxicology, 2021)

Genetic Diversity and Population Structure of Gynaephora qinghaiensis in Yushu Prefecture, Qinghai Province Based on the Mitochondrial COI Gene - Haizhen Wang; Xin Zhong; Huafeng Lin; Shaosong Li; Jiequn Yi; Guren Zhang; Xin Liu; Li Gu (Biochemical Genetics, 2021)

Correction to: 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Bernard R. Agwanda; Rim Al Kubrusli; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Christopher F. Basler; et al. (Archives of Virology, 2021)

2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Bernard R. Agwanda; Rim Al Kubrusli; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Christopher F. Basler; et al. (Archives of Virology, 2021)

Optimization method of first-arrival waveform inversion based on the L-BFGS algorithm - Zhang Kai; Xu Xin; Liu Hong-Xing; Xu Yi-Peng; Li Zhen-Chun; Jiang Ping (Applied Geophysics, 2021)

Fitting of magnetic measurements of Swarm satellites based on 3D surface spline model - Liu Shuang; Feng Yan; Jiang Yi; Li Yi-Jun; Zhang Jin-Yuan (Applied Geophysics, 2021)

Culture Enrichment Combined With Long-Read Sequencing Facilitates Genomic Understanding of Hadal Sediment Microbes - Huan Wang; Meng Wang; Shen Fan; Jie Lu; Yi Lan; Menggong Li; Jiangyan Li; Rulong Liu; Jin Sun; Jiasong Fang; Pei-Yuan Qian; Yu-Zhong Zhang; et al. (Frontiers in Marine Science, 2021)
Culture enrichment was developed to discover the uncharted microbial species in the environmental microbiota. Yet this strategy has not been widely used to study microbes of deep-sea environments. Here, we report the cultivation and metagenomic analysis of oceanic sediment microbiota collected from 6,477 m deep in the Mariana Trench. The sediment samples were cultured anaerobically in the laboratory for 4 months, before being subjected to full-length 16S rRNA gene sequencing using the PacBio technique and metagenome sequencing using both the Illumina and Oxford Nanopore techniques. The 16S rRNA gene analyses revealed 437 operational taxonomic units specific to the cultured microbes, despite the lower diversity of the cultured microbiota in comparison with the original. Metagenome analyses revealed the prevalence of functions related to respiration, energy production, and stress response in the cultured microbes, suggesting these functions may contribute to microbial proliferation under laboratory conditions. Binning of the assembled metagenome contigs of the cultured microbiota generated four nearly complete genomes affiliated to yet unclassified species under the genera Alcanivorax , Idiomarina , Sulfitobacter , and Erythrobacter . Excepting Alcanivorax , the other three genera were almost undetectable in the original samples and largely enriched in the cultured samples. The four genomes possessed a variety of genes for carbohydrate utilization and nitrite reduction, pointing to an ability to respire diverse carbon sources using nitrite as the final electron acceptor. Taken together, the findings suggest that a combination of culture enrichment and long-read sequencing is an ideal way to mine novel microbial species in the hadal environment, particularly species that are rare in their native environmental niches, and thus expand our understanding of the hadal microbial diversity and function.

Linkage and association mapping and Kompetitive allele-specific PCR marker development for improving grain protein content in wheat - Peng Jiang; Peng Zhang; Lei Wu; Yi He; Chang Li; Hongxiang Ma; Xu Zhang (Theoretical and Applied Genetics, 2021)

Abnormal meiosis in fertile and sterile triploid cyprinid fish - Chun Zhang; Qi Li; La Zhu; Wangchao He; Conghui Yang; Hui Zhang; Yu Sun; Luojing Zhou; Yuandong Sun; Shurun Zhu; Chang Wu; Min Tao; et al. (Science China Life Sciences, 2021)

Cenozoic ultrahigh-temperature metamorphism in pelitic granulites from the Mogok metamorphic belt, Myanmar - Si Chen; Yi Chen; Yibing Li; Bin Su; Qinghua Zhang; Me Me Aung; Kyaing Sein (Science China Earth Sciences, 2021)

Correction to: Inhibitory effects of aloperine on voltage-gated Na+ channels in rat ventricular myocytes - Meng-ting Li; Ya-ya Du; Fei Zhong; Jie-ru Wang; You-wei Gu; Yue Zhang; Xuan-tong Huang; Yi-zhou Deng; Zheng-xin Xu (Naunyn-Schmiedeberg's Archives of Pharmacology, 2021)

First report of Colletotrichum aeschynomenes causing leaf anthracnose on Ixora coccinea in China - Min Li; Shaogang Zhang; Zhaoyin Gao; Yi Wang; Wu Zhang; Deqiang Gong; Chao Zhao; Meijiao Hu (Journal of Plant Pathology, 2021)

Elevational distribution and occurrence of arbuscular mycorrhizal fungi in non-host Carex capillacea - Yi Yang; Haibo Zhang; Yabo Chai; Hanjie Xie; Nana Mi; Xiaolin Li; Zhibo Jin; Jingping Gai (Mycorrhiza, 2021)

Mutations in the regulatory regions result in increased streptomycin resistance and keratinase synthesis in Bacillus thuringiensis - Lei Nie; Ruijiao Zhang; Linfang Zhang; Mengyuan Ma; Congcong Li; Yi Zhang; Yafei An; Hongju Xu; Sa Xiao; Tianwen Wang (Archives of Microbiology, 2021)

Divergence in the Aquilegia ecalcarata complex is correlated with geography and climate oscillations: Evidence from plastid genome data - Cheng Xue; Fang‐Dong Geng; Jiao‐Jie Li; Dan‐Qing Zhang; Fei Gao; Lei Huang; Xiao‐Hui Zhang; Ju‐Qing Kang; Jian‐Qiang Zhang; Yi Ren (Molecular Ecology, 2021)
Quaternary climate oscillations and geographical heterogeneity play important roles in determining species and genetic diversity distribution patterns, but how these factors affect the migration and differentiation of East Asian plants species at the population level remains poorly understood. The Aquilegia ecalcarata complex, a group that originated in the Late Tertiary and is widely distributed throughout East Asia, displays high genetic variation that is suitable for studying elaborate phylogeographic patterns and demographic history related to the impact of Quaternary climate and geography. We used plastid genome data from 322 individuals in 60 populations of the A . ecalcarata complex to thoroughly explore the impact of Quaternary climate oscillations and geography on the phylogeographic patterns and demographic history of the A . ecalcarata complex through a series of phylogenetic, divergence time estimation, and demographic history analyses. The dry, cold climate and frequent climate oscillations that occurred during the early Pleistocene and the Mid‐Pleistocene transition led to the differentiation of the A . ecalcarata complex, which was isolated in various areas. Geographically, the A . ecalcarata complex can be divided into Eastern and Western Clades and five subclades, which conform to the divergence of the East Asian flora. Our results clearly show the impact of Quaternary climate and geography on evolutionary history at the population level. These findings promote the understanding of the relationship between plant genetic differentiation and climate and geographical factors of East Asia at the population level.

Induced production of a new polyketide in Penicillium sp. HS-11 by chemical epigenetic manipulation - You-Min Ying; Ling Li; Hang-Fei Yu; Yi-Lian Xu; Lu Huang; Wei Mao; Cui-Ping Tong; Zhi-Dong Zhang; Zha-Jun Zhan; Yun Zhang (Natural Product Research, 2021)

AFAP1-AS1: a rising star among oncogenic long non-coding RNAs - Fang Xiong; Kunjie Zhu; Su Deng; Hongbin Huang; Liting Yang; Zhaojian Gong; Lei Shi; Yi He; Yanyan Tang; Qianjin Liao; Jianjun Yu; Xiaoling Li; et al. (Science China Life Sciences, 2021)

The characterization and candidate gene isolation for a novel male-sterile mutant ms40 in maize - Xiaowei Liu; Yujing Yue; Zicheng Gu; Qiang Huang; Zijin Pan; Zhuofan Zhao; Mingmin Zheng; Zhiming Zhang; Chuan Li; Hongyang Yi; Tao Yu; Moju Cao (Plant Cell Reports, 2021)

The Decision Strategies of Adolescents with Different Emotional Stabilities in Unfair Situations - Yajing Si; Lin Jiang; Chanlin Yi; Qi Zhang; Cunbo Li; Jing Yu; Peiyang Li; Qiang Liu; Feng Wan; Fali Li; Dezhong Yao; Peng Xu (Neuroscience Bulletin, 2021)

Mechanism of cobalt migration in lake sediments during algae blooms - Yazhou Tang; Shiming Ding; Yuexia Wu; Musong Chen; Cai Li; Qitao Yi; Xin Ma; Min Zhang (Journal of Soils and Sediments, 2021)

γ-Aminobutyric Acid Participates in the Adult-Phase Adventitious Rooting Recalcitrance - Xu Li; Xiaozhao Xu; Fei Shen; Wei Li; Changpeng Qiu; Ting Wu; Yi Wang; Xuefeng Xu; Zhenhai Han; Xinzhong Zhang (Journal of Plant Growth Regulation, 2021)
In many tree species especially the rooting-recalcitrant woody perennials, the adventitious root (AR) in the juvenile phase can be easily induced by exogenous auxin, but AR formation becomes recalcitrant in the adult phase. Also, it is reported that the γ-aminobutyric acid (GABA) inhibits primary root growth in Arabidopsis and the AR formation in poplar ( Populus ssp). So far, how GABA affects or is affected by the ontogenetic phase or auxin remains unclear. Here, we used an apple rootstock, Malus xiaojinensis, and tobacco ( Nicotiana benthamiana ) to investigate this question. We first analyzed the content of GABA, the activity of GABA synthetic enzyme GAD, and the expression of the coding gene MxGADs, respectively, in leafy cuttings of juvenile and adult phase. Next, the effect of exogenous GABA on AR formation was examined in in vitro shoots of M. xiaojinensis and tobacco. Interestingly, significant and consistent increases in GABA concentration, GAD activity, and expression of MxGAD genes in response to exogenous indole butyric acid (IBA) were detected in adult-phase cuttings, but not in juvenile-phase cuttings. Exogenous GABA application inhibited the AR formation by delaying rooting time and reducing root number and the total root length in in vitro shoots of both M. xiaojinensis and tobacco. The expression of MxPIN members increased in response to IBA application, but these changes were restrained by the addition of GABA. These results indicate that both the loss of juvenility and IBA are required to trigger GABA accumulation. GABA may affect the AR formation as a co-actor by inhibiting polar auxin transport. Together, these findings facilitate the understanding of the regulatory network among GABA, juvenility, and auxin signaling on the AR formation.

Comparison on characterization and antioxidant activity of exopolysaccharides from two Porphyridium strains - Wei-Nan Wang; Yi Li; Ying Zhang; Wen-Zhou Xiang; Ai-Fen Li; Tao Li (Journal of Applied Phycology, 2021)

Retraction Note: EDAR, LYPLAL1, PRDM16, PAX3, DKK1, TNFSF12, CACNA2D3, and SUPT3H gene variants influence facial morphology in a Eurasian population - Yi Li; Wenting Zhao; Dan Li; Xianming Tao; Ziyi Xiong; Jing Liu; Wei Zhang; Anquan Ji; Kun Tang; Fan Liu; Caixia Li (Human Genetics, 2021)

CCN1 gene polymorphisms associated with congenital heart disease susceptibility in Northwest Chinese population from different high-altitude areas - Wenke Yang; Jun Bai; Xinyu Song; Shasha Zhang; Nana Chen; Tao You; Kang Yi; Zhenglin Li; Dingxiong Xie; Xiaodong Xie (Environmental Science and Pollution Research, 2021)

Cloning and functional characterization of two GsSnRK1 gene promoters from wild soybean - Jun Chen; Qiang Li; Pengmin Zhang; Haoran Lu; Ya Bian; Yi Jian; Yizhu Wang; Xiaodong Ding; Jialei Xiao (Plant Biotechnology Reports, 2021)

Apportioning above- and below-ground effects of moss biocrusts on soil detachment by overland flow in a subtropical climate - Guan-hua Zhang; Liang Yi; Wen-feng Ding; Xu Lei; Yi-ran Wang; Bao-yang Sun; Jian-ming Li (Journal of Mountain Science, 2021)

Atmospheric-Boundary-Layer-Height Variation over Mountainous and Urban Sites in Beijing as Derived from Radar Wind-Profiler Measurements - Raman Solanki; Jianping Guo; Jian Li; Narendra Singh; Xiaoran Guo; Yi Han; Yanmin Lv; Jian Zhang; Boming Liu (Boundary-Layer Meteorology, 2021)

A new indole alkaloid with HUVEC proliferation activities from Nauclea officinalis - Shi-Ying Mai; Yong-Hui Li; Xu-Guang Zhang; Yi-Ran Wang; Jun-Qing Zhang; An Jia (Natural Product Research, 2021)

Analysis of aerosol optical and microphysical characteristics over Yinchuan (China) in 2019 - Lina Xue; Jiandong Mao; Juan Li; Qiang Wang; Yi Zhang (International Journal of Remote Sensing, 2021)

Experimental study on integrated and autonomous conductivity-temperature-depth (CTD) sensor applied for underwater glider - Bin Lv; Hai-lin Liu; Yi-fan Hu; Cheng-xuan Wu; Jie Liu; Hai-jing He; Jie Chen; Jian Yuan; Zhao-wen Zhang; Lin Cao; Hui Li (Marine Georesources & Geotechnology, 2021)

Genome-wide Identification, Classification, Evolutionary Expansion and Expression of Rboh Family Genes in Pepper (Capsicum annuum L.) - Jianwei Zhang; Yongdong Xie; Barkat Ali; Waleed Ahmed; Yi Tang; Huanxiu Li (Tropical Plant Biology, 2021)

Plant multiscale networks: charting plant connectivity by multi-level analysis and imaging techniques - Xi Zhang; Yi Man; Xiaohong Zhuang; Jinbo Shen; Yi Zhang; Yaning Cui; Meng Yu; Jingjing Xing; Guangchao Wang; Na Lian; Zijian Hu; Lingyu Ma; et al. (Science China Life Sciences, 2021)

Association between large artery stenosis, cerebral small vessel disease and risk of ischemic stroke - Fei Han; Ding-Ding Zhang; Fei-Fei Zhai; Jun Xue; Jiang-Tao Zhang; Shuang Yan; Li-Xin Zhou; Jun Ni; Ming Yao; Meng Yang; Ming-Li Li; Zheng-Yu Jin; et al. (Science China Life Sciences, 2021)

Genome-wide identification of ABA receptor PYL/RCAR gene family and their response to cold stress in Medicago sativa L - Lili Nian; Xiaoning Zhang; Xianfeng Yi; Xuelu Liu; Noor ul Ain; Yingbo Yang; Xiaodan Li; Fasih Ullah Haider; Xiaolin Zhu (Physiology and Molecular Biology of Plants, 2021)

Research progress on the impact of flood discharge atomization on the ecological environment - Li Lin; Yi Li; Wei Zhang; Zhuo Huang; Duan Chen; Min Liu; John Crittenden (Natural Hazards, 2021)

BDNF Participates in Chronic Constriction Injury-Induced Neuropathic Pain via Transcriptionally Activating P2X7 in Primary Sensory Neurons - Yi Wu; Zhiwen Shen; Hui Xu; Kun Zhang; Mingyan Guo; Fei Wang; Junhua Li (Molecular Neurobiology, 2021)

Planktonic ciliate trait structure variation over Yap, Mariana, and Caroline seamounts in the tropical western Pacific Ocean - Chaofeng Wang; Haibo Li; Yi Dong; Li Zhao; Gérald Gregori; Yuan Zhao; Wuchang Zhang; Tian Xiao (Journal of Oceanology and Limnology, 2021)

Synthesis and evaluation of iridium(III) complexes on antineoplastic activity against human gastric carcinoma SGC-7901 cells - Li Tian; Yuanyuan Zhang; Huiwen Zhang; Yi Zhou; Wenlong Li; Yuhan Yuan; Jing Hao; Linlin Yang; Yunjun Liu (JBIC Journal of Biological Inorganic Chemistry, 2021)

Randomized, placebo-controlled trial of orally administered vitamin K1 for warfarin-associated coagulopathy in Chinese patients with mechanical heart valves - Heng Zhang; Mei Li; Xue-lian Ao; Yi-jun Dong; Li Dong (European Journal of Clinical Pharmacology, 2021)

Migration and transformation of heavy metals in hyperaccumulators during the thermal treatment: a review - Wei Su; Xinyan Li; Hongshuo Zhang; Yi Xing; Ping Liu; Changqing Cai (Environmental Science and Pollution Research, 2021)

Fate processes of Parabens, Triclocarban and Triclosan during wastewater treatment: assessment via field measurements and model simulations - Zi-Feng Zhang; Lu Wang; Xianming Zhang; Xue Zhang; Yi-Fan Li; Anatoly Nikolaev; Wen-Long Li (Environmental Science and Pollution Research, 2021)

Adsorption of U(VI) from aqueous solution by using KMnO4-modified hazelnut shell activated carbon: characterisation and artificial neural network modelling - Mijia Zhu; Fanxiu Li; Wu Chen; Xianqing Yin; Zhengji Yi; Shuyong Zhang (Environmental Science and Pollution Research, 2021)

Long-term PM2.5 exposure and survival among cardiovascular disease patients in Beijing, China - Dandan Xu; Yi Zhang; Qinghua Sun; Xiaofeng Wang; Tiantian Li (Environmental Science and Pollution Research, 2021)

High-throughput sequencing clarifies the spatial structures of microbial communities in cadmium-polluted rice soils - Li Song; Zhenzhi Pan; Yi Dai; Lin Chen; Li Zhang; Qilin Liao; Xiezhi Yu; Hongyan Guo; Guisheng Zhou (Environmental Science and Pollution Research, 2021)

An experimental study on cutting tool hardness optimization for shield TBMs during dense fine silty sand ground tunneling - Xiao-Ping Zhang; Shao-Hui Tang; Quan-Sheng Liu; Xin-Bin Tu; Peng Chen; Fang-Yi Li (Bulletin of Engineering Geology and the Environment, 2021)

Design of overburden thickness for underground arsenals based on numerical simulation of underground explosion caves - Xingui Zhang; Jiaxiong Zhu; Li’e Yan; Yi Zeng; Qingsheng Chen; Mangyuan Li (Arabian Journal of Geosciences, 2021)

Rock physics inversion based on an optimized MCMC method - Jia-Jia Zhang; Hong-Bing Li; Guang-Zhi Zhang; Yi-Peng Gu; Zhuo-Fan Liu (Applied Geophysics, 2021)

Taxonomic description of Pseudomonas rhizovicinus sp. nov., isolated from the rhizosphere of a desert shrub Haloxylon ammodendron - Ao-Lei He; Hui-Ru Li; Hui-Ping Li; Jing-Yi Gou; Jia Chen; Qi Zhao; Jin-Lin Zhang (Antonie van Leeuwenhoek, 2021)

The Significant Role of Radiosonde-measured Cloud-base Height in the Estimation of Cloud Radiative Forcing - Hui Xu; Jianping Guo; Jian Li; Lin Liu; Tianmeng Chen; Xiaoran Guo; Yanmin Lyu; Ding Wang; Yi Han; Qi Chen; Yong Zhang (Advances in Atmospheric Sciences, 2021)

Tracing Nutrients and Organic Matter Changes in Eutrophic Wenchang (China) and Oligotrophic Krka (Croatia) Estuaries: A Comparative Study - You-You Hao; Zhuo-Yi Zhu; Fu-Tao Fang; Tihana Novak; Milan Čanković; Enis Hrustić; Zrinka Ljubešić; Ming Li; Jin-Zhou Du; Rui-Feng Zhang; Blaženka Gašparović (Frontiers in Marine Science, 2021)
Estuaries modify the concentration and composition of riverine nutrients and organic matter (OM), which eventually determine the riverine flux effect to coasts. Nutrients, organic carbon (OC), pigments, and amino acids (AAs) from the samples collected in the eutrophic Wenchang River Estuary (WRE) in China and the oligotrophic Krka River Estuary (KRE) in Croatia were analyzed in order to have a better understanding of how estuaries regulate terrestrial materials. We found a clear increase of dissolved inorganic nitrogen (DIN) concentration and its subsequent decrease due to the removal of DIN (over 100 μM) in the WRE, whereas DIN showed minor variation lengthwise in the KRE, i.e., with the salinity changes, ranging between 1.0 and 5.8 μM. The elevated algae-derived OC, dissolved organic nitrogen, and particulate AAs nitrogen suggest that the OM assimilation may explain approximately one-third of the DIN removal in the WRE, whereas in the oligotrophic KRE, such inorganic to organic transformation is not likely to be significant. Due to the prominent estuarine nitrogen removal/assimilation process, DIN/dissolved inorganic phosphorus (DIP) ratio was as high as 425 in the upper WRE under strong riverine influence, but it declined to as low as 5.4 at the mouth of WRE, that is even lower than DIN/DIP ratio at the mouth of oligotrophic KRE (12). When compared with other rivers worldwide, the Wenchang River showed high nutrients and organic carbon yields. Given the contrasting estuarine process (e.g., DIN removal) between the KRE and the WRE, apparent high nutrient yield from eutrophic rivers should be viewed with caution in ocean studies as the final impact to coastal zone could be similar to the oligotrophic rivers like the KRE.

Elevated pCO2 Impedes Succession of Phytoplankton Community From Diatoms to Dinoflagellates Along With Increased Abundance of Viruses and Bacteria - Ruiping Huang; Jiazhen Sun; Yunlan Yang; Xiaowen Jiang; Zhen Wang; Xue Song; Tifeng Wang; Di Zhang; He Li; Xiangqi Yi; Shouchang Chen; Nanou Bao; et al. (Frontiers in Marine Science, 2021)
Eutrophic coastal regions are highly productive and greatly influenced by human activities. Primary production supporting the coastal ecosystems is supposed to be affected by progressive ocean acidification driven by increasing CO 2 emissions. In order to investigate the effects of high p CO 2 (HC) on eutrophic plankton community structure and ecological functions, we employed 9 mesocosms and carried out an experiment under ambient (∼410 ppmv) and future high (1000 ppmv) atmospheric p CO 2 conditions, using in situ plankton community in Wuyuan Bay, East China Sea. Our results showed that HC along with natural seawater temperature rise significantly boosted biomass of diatoms with decreased abundance of dinoflagellates in the late stage of the experiment, demonstrating that HC repressed the succession from diatoms to dinoflagellates, a phenomenon observed during algal blooms in the East China Sea. HC did not significantly influence the primary production or biogenic silica contents of the phytoplankton assemblages. However, the HC treatments increased the abundance of viruses and heterotrophic bacteria, reflecting a refueling of nutrients for phytoplankton growth from virus-mediated cell lysis and bacterial degradation of organic matters. Conclusively, our results suggest that increasing CO 2 concentrations can modulate plankton structure including the succession of phytoplankton community and the abundance of viruses and bacteria in eutrophic coastal waters, which may lead to altered biogeochemical cycles of carbon and nutrients.

Comparison of different atmospheric phase screen correction models in ground-based radar interferometry for landslide and open-pit mine monitoring - Bingquan Li; Wenliang Jiang; Yongsheng Li; Yi Luo; Qisong Jiao; Xin Wang; Jingfa Zhang (International Journal of Remote Sensing, 2021)

Iodinated Contrast Agents Reduce the Efficacy of Intravenous Recombinant Tissue-Type Plasminogen Activator in Acute Ischemic Stroke Patients: a Multicenter Cohort Study - Zhicai Chen; Chao Xu; Wansi Zhong; Xiaoxian Gong; Haitao Hu; Xuting Zhang; Yi Chen; Qingqing Li; Zhongyu Luo; Zhuojian Chen; Min Lou (Translational Stroke Research, 2021)

TREM-1 Exacerbates Neuroinflammatory Injury via NLRP3 Inflammasome-Mediated Pyroptosis in Experimental Subarachnoid Hemorrhage - Pengfei Xu; Ye Hong; Yi Xie; Kang Yuan; Juanji Li; Rui Sun; Xiaohao Zhang; Xiaolei Shi; Rongrong Li; Jiaonan Wu; Xinfeng Liu; Wei Hu; et al. (Translational Stroke Research, 2021)

Proteomics provides individualized options of precision medicine for patients with gastric cancer - Wenwen Huang; Dongdong Zhan; Yazhuo Li; Nairen Zheng; Xin Wei; Bin Bai; Kecheng Zhang; Mingwei Liu; Xuefei Zhao; Xiaotian Ni; Xia Xia; Jinwen Shi; et al. (Science China Life Sciences, 2021)

Targeted sequencing and integrative analysis to prioritize candidate genes in neurodevelopmental disorders - Yi Zhang; Tao Wang; Yan Wang; Kun Xia; Jinchen Li; Zhongsheng Sun (Molecular Neurobiology, 2021)
Neurodevelopmental disorders (NDDs) are a group of diseases characterized by high heterogeneity and frequently co-occurring symptoms. The mutational spectrum in patients with NDDs is largely incomplete. Here, we sequenced 547 genes from 1102 patients with NDDs and validated 1271 potential functional variants, including 108 de novo variants (DNVs) in 78 autosomal genes and seven inherited hemizygous variants in six X chromosomal genes. Notably, 36 of these 78 genes are the first to be reported in Chinese patients with NDDs. By integrating our genetic data with public data, we prioritized 212 NDD candidate genes with FDR < 0.1, including 17 novel genes. The novel candidate genes interacted or were co-expressed with known candidate genes, forming a functional network involved in known pathways. We highlighted MSL2 , which carried two de novo protein-truncating variants (p.L192Vfs*3 and p.S486Ifs*11) and was frequently connected with known candidate genes. This study provides the mutational spectrum of NDDs in China and prioritizes 212 NDD candidate genes for further functional validation and genetic counseling.

Effects of Mn2+ on neutral lipid content, C4 pathway, and related gene expression in Phaeodactylum tricornutum - Rong-Shi Chen; Li Zhang; Feng-Juan Wei; Lan-Ying Yuan; Pu Zhao; He-Yu Wang; Yi-Fu Gong (Journal of Applied Phycology, 2021)

Genomic selection to introgress exotic maize germplasm into elite maize in China to improve kernel dehydration rate - Hongjun Yong; Nan Wang; Xiaojun Yang; Fengyi Zhang; Juan Tang; Zhiyuan Yang; Xinzhe Zhao; Yi Li; Mingshun Li; Degui Zhang; Zhuanfang Hao; Jianfeng Weng; et al. (Euphytica, 2021)

The preliminary evaluation of differential characteristics and factor evaluation of the microbial structure of rural household toilet excrement in China - Yi Gao; Houyu Li; Bo Yang; Xiaocheng Wei; Chunxue Zhang; Yan Xu; Xiangqun Zheng (Environmental Science and Pollution Research, 2021)

Genetic changes and evolutionary analysis of canine circovirus - Lin Wang; Yifan li; Zhiyuan Guo; Ying Yi; Han Zhang; Haikun Shangguan; Chengshi Huang; Junwei Ge (Archives of Virology, 2021)

A study on the characteristics of seismic wave propagation in fractured marlstone reservoirs based on mechanical principles - Min Zhang; Zhenchun Li; Qiang Liu; Jidong Yi; Kexin Li (Arabian Journal of Geosciences, 2021)

Neuroprotective triterpene saponins from the leaves of Panax notoginseng - Ji-Wu Huang; Yi-Qian Du; Chuang-Jun Li; Jing-Zhi Yang; Jie Ma; Ying-Da Zang; Nai-Hong Chen; Dong-Ming Zhang (Natural Product Research, 2021)

Quantifying nitrate pollution sources of the drinking water source area using a Bayesian isotope mixing model in the northeastern suburbs of Beijing, China - Liangsuo Ren; Lirong Cheng; Shurong Zhang; Aizhong Ding; Yi Zhu; Chunlei Lu; Yu Li; Qing Yang; Jie Li (Isotopes in Environmental and Health Studies, 2021)

Comparative analysis of sRNAs, degradome and transcriptomics in sweet sorghum reveals the regulatory roles of miRNAs in Cd accumulation and tolerance - Weitao Jia; Kangqi Lin; Tengxue Lou; Juanjuan Feng; Sulian Lv; Ping Jiang; Ze Yi; Xuan Zhang; Duoliya Wang; Zijing Guo; Yetao Tang; Rongliang Qiu; et al. (Planta, 2021)

Inhibitory effects of aloperine on voltage-gated Na+ channels in rat ventricular myocytes - Meng-ting Li; Ya-ya Du; Fei Zhong; Jie-ru Wang; You-wei Gu; Yue Zhang; Xuan-tong Huang; Yi-zhou Deng; Zheng-xin Xu (Naunyn-Schmiedeberg's Archives of Pharmacology, 2021)

Genetic Analysis of ZNF Protein Family Members for Early-Onset Parkinson’s Disease in Chinese Population - Chun Yu Li; Ru Wei Ou; Yong Ping Chen; Xiao Jing Gu; Qian Qian Wei; Bei Cao; Ling Yu Zhang; Yan Bing Hou; Kun Cheng Liu; Xue Ping Chen; Wei Song; Bi Zhao; et al. (Molecular Neurobiology, 2021)

Characteristics of RNA alternative splicing and its potential roles in ginsenoside biosynthesis in a single plant of ginseng, Panax ginseng C.A. Meyer - Yilai Han; Lei Zhu; Li Li; Yanfang Wang; Mingzhu Zhao; Kangyu Wang; Chunyu Sun; Jing Chen; Lingyu Liu; Ping Chen; Jun Lei; Yi Wang; et al. (Molecular Genetics and Genomics, 2021)

Curcumin suppresses oxidative stress via regulation of ROS/NF-κB signaling pathway to protect retinal vascular endothelial cell in diabetic retinopathy - Jiang Huang; Quanyong Yi; Yuhong You; Yao Chen; Tongtong Niu; Yi Li; Ji Zhang; Xiaoyan Ji; Guoxu Xu; Weijie Zou; Fangfang Ji; Weifeng Luo (Molecular & Cellular Toxicology, 2021)

Fusarium solani G6, a novel vitexin-producing endophytic fungus: characterization, yield improvement and osteoblastic proliferation activity - Pei-jia Tang; Zhi-hui Zhang; Li-li Niu; Cheng-bo Gu; Wen-yi Zheng; Hai-chao Cui; Xiao-han Yuan (Biotechnology Letters, 2021)

Mapping fetal brain development based on automated segmentation and 4D brain atlasing - Haotian Li; Guohui Yan; Wanrong Luo; Tingting Liu; Yan Wang; Ruibin Liu; Weihao Zheng; Yi Zhang; Kui Li; Li Zhao; Catherine Limperopoulos; Yu Zou; et al. (Brain Structure and Function, 2021)

Establishment of an indirect ELISA-based method involving the use of a multiepitope recombinant S protein to detect antibodies against canine coronavirus - Yun-Feng Hao; Shao-Han Li; Guang-Zhi Zhang; Yi Xu; Guang-zong Long; Xiao-xiong Lu; Shang-Jin Cui; Tong Qin (Archives of Virology, 2021)

Transforming growth factor β as a possible independent factor in chronic hepatitis B - Ming-hui Li; Yao Lu; Fang-fang Sun; Qi-qi Chen; Lu Zhang; Hui-hui Lu; Zhan Zeng; Wei Yi; Yao Xie (Archives of Virology, 2021)

Glaciibacter flavus sp. nov., isolated from a lichen sample - De-Feng An; Long-Qian Jiang; Kun Zhang; Gui-Ding Li; Xin-Yu Wang; Ming-Guo Jiang; Lei Lang; Li-Song Wang; Johannes F. Imhoff; Cheng-Lin Jiang; Yi Jiang (Archives of Microbiology, 2021)

The effect of consecutive ambient air pollution on the hospital admission from chronic obstructive pulmonary disease in the Chengdu region, China - Yi Zhang; Ziyue Wang; Yu Cao; Lifu Zhang; Guan Wang; Fangjie Dong; Ren Deng; Baogen Guo; Li Zeng; Peng Wang; Ruimei Dai; Yu Ran; et al. (Air Quality, Atmosphere & Health, 2021)

Transcutaneous Auricular Vagus Nerve Stimulation: From Concept to Application - Yu Wang; Shao-Yuan Li; Dan Wang; Mo-Zheng Wu; Jia-Kai He; Jin-Ling Zhang; Bin Zhao; Li-Wei Hou; Jun-Ying Wang; Lei Wang; Yi-Fei Wang; Yue Zhang; et al. (Neuroscience Bulletin, 2021)

Syntheses and anticancer activities of novel glucosylated (−)-epigallocatechin-3-gallate derivatives linked via triazole rings - Bo-Ya Shi; Ze-Hao Wang; Ning Zhang; Yin-Rong Xie; Xiu-Li Sun; Hao-Nan Yang; Yi-Long Wu; Cheng-Ting Zi; Xuan-Jun Wang; Jun Sheng (Medicinal Chemistry Research, 2021)

Biochar Alters Inorganic Phosphorus Fractions in Tobacco-growing Soil - Wenli Zhang; Caibin Li; Guitong Li; Qimei Lin; Xiaorong Zhao; Yi He; Yanxiang Liu; Zhenbao Luo (Journal of Soil Science and Plant Nutrition, 2021)

Identification and genetic analysis of two maize CMS-T mutants obtained from out-space-flighted seeds - Hongyang Yi; Caibo Zhang; Chuan Li; Jing Wang; Tao Yu; Yongming Liu; Moju Cao (Genetic Resources and Crop Evolution, 2021)

Analysis of variation patterns in rice milled quality in the offspring of indica–japonica hybridization - Ting Mao; Zhan Zhang; Shan-Jun Ni; Yi-Zhou Zhao; Xin Li; Li-Li Zhang; Yan Liu; Xu Li (Genetic Resources and Crop Evolution, 2021)

Response of water quality to land use in hydrologic response unit and riparian buffer along the Dan River, China - Xiaojun Liu; Yi Zhang; Zhanbin Li; Peng Li; Guoce Xu; Yuting Cheng; Tiegang Zhang (Environmental Science and Pollution Research, 2021)

Projected changes in the characteristics of the East Asian summer monsoonal front and their impacts on the regional precipitation - Yana Li; Ngar-Cheung Lau; Chi-Yung Tam; Ho-Nam Cheung; Yi Deng; Henian Zhang (Climate Dynamics, 2021)

First record of the Middle Darriwilian δ13C excursion (MDICE) in southern Xizang (Tibet), China, and its implications - Shenyang Yu; Xiang Fang; Yuandong Zhang; Yong Yi Zhen; Wenjie Li; Yue Li; Axel Munnecke (Carbonates and Evaporites, 2021)

Differences in topological properties of functional brain networks between menstrually-related and non-menstrual migraine without aura - Yutong Zhang; Tao Xu; Ziwen Wang; Dehua Li; Jiarong Du; Yi Wen; Yu Zhao; Huaqiang Liao; Fanrong Liang; Ling Zhao (Brain Imaging and Behavior, 2021)
Menstrually-related migraine without aura refers to a specific type of migraine that is associated with the female ovarian cycle. Compared with non-menstrual migraine without aura, in menstrually-related migraine without aura, there are additional attacks of migraine outside of the menstrual period. Menstrually-related migraine without aura tends to be less responsive to acute treatment and more prone to relapse than non-menstrual migraine without aura. Currently menstrually-related migraine without aura is treated no differently from any other migraine but, the differences in the central mechanisms underlying menstrually-related migraine without aura and non-menstrual migraine without aura remain poorly understood. Here, using resting-state functional magnetic resonance imaging and graph theory approaches, we aimed to explore the differences in topological properties of functional networks in 51 menstrually-related migraine without aura patients and 47 non-menstrual migraine without aura patients. The major finding of our study was that significant differences in topological properties between the two groups were mainly evident in the nodal centrality of the inferior frontal gyrus and the thalamus. Nodal centrality in inferior frontal gyrus was negatively correlated with Headache Impact Test questionnaire scores in the menstrually-related migraine without aura patients. Partial least squares correlation analysis revealed enhanced correlations of inferior frontal gyrus to pain-related behavior in the non-menstrual migraine without aura group, while within the menstrually-related migraine without aura group these effects were non-significant. These results indicate that the regulatory mechanisms in the central nervous system may differ between the two subtypes of migraine. The results provide novel insights into the pathophysiology of different subtypes of migraine, and could help us to enhance their clinical diagnosis and treatment.

Erratum to: Spatio-temporal variation of Fraction of Photosynthetically Active Radiation absorbed by vegetation in the Hengduan Mountains, China - Zheng-lan Yang; Ting-bin Zhang; Gui-hua Yi; Jing-ji Li; Yan-bin Qin; Yang Chen (Journal of Mountain Science, 2021)

First Records of Late Triassic Conodont Fauna and δ13Ccarb from the Dengdengqiao Section, Dangchang County, Gansu Province, Northwestern China - Hanxiao Li; Miaoyan Wang; Muhui Zhang; Paul B. Wignall; Manuel Rigo; Yanlong Chen; Xianlang Wu; Zhumin Ouyang; Baojin Wu; Zhaoyang Yi; Zaitian Zhang; Xulong Lai (Journal of Earth Science, 2021)

Pigmentibacter ruber gen. nov., sp. nov., a novel bacterium of the family Silvanigrellaceae isolated from human blood - Na Peng; Wen Xu; Hai-Min Luo; Peng-Wen Ouyang; Bin Jiang; Zhi-Hua Zhang; You-De Cao; Li-Ming Tan; Ping-Hua Qu; Liang-Yi Xie (Antonie van Leeuwenhoek, 2021)

Physiological determinants of biogeography: The importance of metabolic depression to heat tolerance - Ming‐ling Liao; Gao‐yang Li; Jie Wang; David J. Marshall; Tin Yan Hui; Shu‐yang Ma; Yi‐min Zhang; Brian Helmuth; Yun‐wei Dong (Global Change Biology, 2021)
A quantitative understanding of physiological thermal responses is vital for forecasting species distributional shifts in response to climate change. Many studies have focused on metabolic rate as a global metric for analyzing the sublethal effects of changing environments on physiology. Thermal performance curves (TPCs) have been suggested as a viable analytical framework, but standard TPCs may not fully capture physiological responses, due in part to failure to consider the process of metabolic depression. We derived a model based on the nonlinear regression of biological temperature‐dependent rate processes and built a heart rate data set for 26 species of intertidal molluscs distributed from 33°S to ~40°N. We then calculated physiological thermal performance limits with continuous heating using , the temperature at which heart rate is decreased to 50% of the maximal rate, as a more realistic measure of upper thermal limits. Results indicate that heat‐induced metabolic depression of cardiac performance is a common adaptive response that allows tolerance of harsh environments. Furthermore, our model accounted for the high inter‐individual variability in the shape of cardiac TPCs. We then used these TPCs to calculate physiological thermal safety margins (pTSM), the difference between the maximal operative temperature (95th percentile of field temperatures) and of each individual. Using pTSMs, we developed a physiological species distribution model (pSDM) to forecast future geographic distributions. pSDM results indicate that climate‐induced species range shifts are potentially less severe than predicted by a simple correlative SDM. Species with metabolic depression below the optimum temperature will be more thermal resistant at their warm trailing edges. High intraspecific variability further suggests that models based on species‐level vulnerability to environmental change may be problematic. This multi‐scale, mechanistic understanding that incorporates metabolic depression and inter‐individual variability in thermal response enables better predictions about the relationship between thermal stress and species distributions.

KCNQ Channels in the Mesolimbic Reward Circuit Regulate Nociception in Chronic Pain in Mice - Hao-Ran Wang; Su-Wan Hu; Song Zhang; Yu Song; Xiao-Yi Wang; Lei Wang; Yang-Yang Li; Yu-Mei Yu; He Liu; Di Liu; Hai-Lei Ding; Jun-Li Cao (Neuroscience Bulletin, 2021)
Mesocorticolimbic dopaminergic (DA) neurons have been implicated in regulating nociception in chronic pain, yet the mechanisms are barely understood. Here, we found that chronic constructive injury (CCI) in mice increased the firing activity and decreased the KCNQ channel-mediated M-currents in ventral tegmental area (VTA) DA neurons projecting to the nucleus accumbens (NAc). Chemogenetic inhibition of the VTA-to-NAc DA neurons alleviated CCI-induced thermal nociception. Opposite changes in the firing activity and M-currents were recorded in VTA DA neurons projecting to the medial prefrontal cortex (mPFC) but did not affect nociception. In addition, intra-VTA injection of retigabine, a KCNQ opener, while reversing the changes of the VTA-to-NAc DA neurons, alleviated CCI-induced nociception, and this was abolished by injecting exogenous BDNF into the NAc. Taken together, these findings highlight a vital role of KCNQ channel-mediated modulation of mesolimbic DA activity in regulating thermal nociception in the chronic pain state.

Neuromodulation-Based Stem Cell Therapy in Brain Repair: Recent Advances and Future Perspectives - Ti-Fei Yuan; Yi Dong; Li Zhang; Jieyu Qi; Chun Yao; Yongjun Wang; Renjie Chai; Yan Liu; Kwok-Fai So (Neuroscience Bulletin, 2021)

A Role for Transmembrane Protein 16C/Slack Impairment in Excitatory Nociceptive Synaptic Plasticity in the Pathogenesis of Remifentanil-induced Hyperalgesia in Rats - Yize Li; Linlin Zhang; Jing Li; Chunyan Wang; Yi Chen; Yuan Yuan; Keliang Xie; Guolin Wang; Yonghao Yu (Neuroscience Bulletin, 2021)

Design, synthesis and evaluation of dihydrotriazine derivatives-bearing 5-aryloxypyrazole moieties as antibacterial agents - Tian-Yi Zhang; Chun-Shi Li; Ming-Yue Cui; Xue-Qian Bai; Jiang-Hui Chen; Ze-Wen Song; Bo Feng; Xue-Kun Liu (Molecular Diversity, 2021)

Diversity, metabolism and cultivation of archaea in mangrove ecosystems - Cui-Jing Zhang; Yu-Lian Chen; Yi-Hua Sun; Jie Pan; Ming-Wei Cai; Meng Li (Marine Life Science & Technology, 2021)

Bjerkandera adusta M1 inhibits the growth of Fusarium oxysporum f. sp. conglutinans and fusarium wilt incidence in Brassica napus L. - Xiao Feng; Su-Ping Li; Yi-Fan Lu; Jing-Jie Zhang; Yun-Yun Zhu; Yong Li; Hong-Jun Yang; Xin-Hua He (Journal of Plant Pathology, 2021)

Establishment and characterization of 38 novel patient-derived primary cancer cell lines using multi-region sampling revealing intra-tumor heterogeneity of gallbladder carcinoma - Feiling Feng; Qingbao Cheng; Bin Li; Chen Liu; Huizhen Wang; Bin Li; Xiaoya Xu; Yong Yu; Zishuo Chen; Xiaobing Wu; Hua Dong; Kaijian Chu; et al. (Human Cell, 2021)
Gallbladder carcinoma (GBC) is a lethal biliary tract malignant neoplasm. Patient-derived primary cancer cell lines (PDPCs) are appropriate models to explore biological characteristics and potential therapeutics; however, there is a lack of PDPCs in GBC. In this study, we aimed to establish and characterize the GBC PDPCs, and further investigated the intra-tumor heterogeneity (ITH). Multi-region sampling (3–9 regions) of the operable tumor tissue samples was used to establish PDPCs. Short tandem repeat genotyping for cell authentication and karyotyping was performed, followed by whole-exome sequencing and RNA sequencing to assess the ITH at the genetic and transcriptional levels, respectively. Thirty-eight PDPCs were successfully established from seven GBC patients and characterized. ITH was observed with a median of 38.3% mutations being heterogeneous (range, 26.6–59.4%) across all patients. Similar with other tumor types, TP53 mutations were always truncal. In addition, there were three genes, KMT2C , CDKN2A , and ARID1A , with truncal mutations in at least two patients. A median of 370 differentially expressed genes (DEGs) was identified per patient. Distinct expression patterns were observed between major histocompatibility complex (MHC) class I and II genes. We found the expression of MHC class II genes in the PDPC samples was closely regulated by CIITA , while that of MHC class I genes were not correlated with CIITA expression. The PDPCs established from GBC patients can serve as novel in vitro models to identify the ITH, which may pave a crucial molecular foundation for enhanced understanding of tumorigenesis and progression.

Different physiological responses of C3 and C4 plants to nanomaterials - Tonghao Bai; Peng Zhang; Zhiling Guo; Andrew J. Chetwynd; Mei Zhang; Muhammad Adeel; Mingshu Li; Kerui Guo; Ruize Gao; Jianwei Li; Yi Hao; Yukui Rui (Environmental Science and Pollution Research, 2021)

Efficient electrokinetic remediation of heavy metals from MSWI fly ash using approaching anode integrated with permeable reactive barrier - Huilin Li; Yi Zheng; Lin Yu; Huirong Lin; Manli Zhang; Binquan Jiao; YanChyuan Shiau; Dongwei Li (Environmental Science and Pollution Research, 2021)

Experimental and simulation investigations of cyclic water injection in low-permeability reservoir - Xuangang Meng; Qiukai Zhang; Xiaoxu Dai; Saihong Xue; Xiaowei Feng; Yi Zhang; Bin Tu; Xiangfang Li (Arabian Journal of Geosciences, 2021)

Effects of Co-Applications of Biochar and Solid Digestate on Enzyme Activities and Heavy Metals Bioavailability in Cd-Polluted Greenhouse Soil - Shuaixing Xue; Fengfen Chen; Yuying Wang; Zhijiang Shao; Congguang Zhang; Ling Qiu; Yi Ran; Li He (Water, Air, & Soil Pollution, 2021)

Orbital-scale Asian summer monsoon variations: Paradox and exploration - Hai Cheng; Haiwei Zhang; Yanjun Cai; Zhengguo Shi; Liang Yi; Chenglong Deng; Qingzhen Hao; Youbing Peng; Ashish Sinha; Hanying Li; Jingyao Zhao; Ye Tian; et al. (Science China Earth Sciences, 2021)

The circular RNA circSlc7a11 promotes bone cancer pain pathogenesis in rats by modulating LLC-WRC 256 cell proliferation and apoptosis - Han-Wen Chen; Xiao-Xia Zhang; Zhu-Ding Peng; Zu-Min Xing; Yi-Wen Zhang; Ya-Lan Li (Molecular and Cellular Biochemistry, 2021)
Treatment of bone cancer pain (BCP) caused by bone metastasis in advanced cancers remains a challenge in clinical oncology, and the underlying mechanisms of BCP are poorly understood. This study aimed to investigate the pathogenic roles of circular RNAs (circRNAs) in regulating cancer cell proliferation and BCP development. Eight differentially expressed circRNAs in the rat spinal cord were validated by agarose gel electrophoresis and Sanger sequencing. Expression of circRNAs and mRNAs was detected by quantitative RT-PCR. MTS assay and flow cytometry were performed to analyze cell proliferation and apoptosis, respectively. Differentially expressed mRNA profiles were characterized by deep RNA sequencing, hierarchical clustering, and functional categorization. The interactions among circRNAs, microRNAs (miRNAs), and mRNAs were predicted using TargetScan. Additionally, western blot was performed to determine the protein levels of Pax8, Isg15, and Cxcl10. Multiple circRNAs were differentially expressed in the spinal cords of BCP model rats; of these, circSlc7a11 showed the greatest increase in expression. The overexpression of circSlc7a11 significantly promoted cell proliferation and repressed apoptosis of LLC-WRC 256 and UMR-106 cells, whereas circSlc7a11 silencing produced the opposite effects. Altered expression of circSlc7a11 also induced substantial changes in the mRNA expression profiles of LLC-WRC 256 cells; these changes were linked to multiple apoptotic processes and signaling pathways, such as the chemokine signaling pathway, and formed a complex circRNA/miRNA/mRNA network. Additionally, Pax8, Isg15, and Cxc110 protein level in LLC-WRC 256 cells was consistent with the mRNA results. The circRNA circSlc7a11 regulates rat BCP development by modulating LLC-WRC 256 cell proliferation and apoptosis through multiple-signaling mechanisms.

A novel homozygous nonsense mutation in the CA2 gene (c.368G>A, p.W123X) linked to carbonic anhydrase II deficiency syndrome in a Chinese family - Yan Yang; Nie Tang; Ying Zhu; Lei Zhang; Xu Cao; Limei Liu; Wei Xia; Pengqiu Li; Yi Yang (Metabolic Brain Disease, 2021)

Experimental validation of a new semi-empirical impact force model of the dry granular flow impact against a rigid barrier - Yuan-Jun Jiang; Xiao-Yi Fan; Li-Jun Su; Si-you Xiao; Jing Sui; Rui-Xiao Zhang; Yue Song; Zhi-Wen Shen (Landslides, 2021)

The prevalence and risks of major comorbidities among inpatients with pulmonary tuberculosis in China from a gender and age perspective: a large-scale multicenter observational study - Wanli Kang; Jian Du; Song Yang; Jiajia Yu; Hongyan Chen; Jianxiong Liu; Jinshan Ma; Mingwu Li; Jingmin Qin; Wei Shu; Peilan Zong; Yi Zhang; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

The Fe3O4-modified biochar reduces arsenic availability in soil and arsenic accumulation in indica rice (Oryza sativa L.) - Yao Yao; Hang Zhou; Xiu-Lan Yan; Xiao Yang; Kang-Wen Huang; Juan Liu; Li-Juan Li; Jing-Yi Zhang; Jiao-Feng Gu; Yaoyu Zhou; Bo-Han Liao (Environmental Science and Pollution Research, 2021)

Nitrogen Enrichment Reduces Nitrogen and Phosphorus Resorption Through Changes to Species Resorption and Plant Community Composition - Xiao-Tao Lü; Shuang-Li Hou; Sasha Reed; Jiang-Xia Yin; Yan-Yu Hu; Hai-Wei Wei; Zhi-Wei Zhang; Guo-Jiao Yang; Zhuo-Yi Liu; Xing-Guo Han (Ecosystems, 2021)

Spatio-temporal variation of Fraction of Photosynthetically Active Radiation absorbed by vegetation in the Hengduan Mountains, China - Zheng-Ian Yang; Ting-bin Zhang; Gui-hua Yi; Jing-ji Li; Yan-bin Qin; Yang Chen (Journal of Mountain Science, 2021)

Integrated Exploration Model for Concealed Ore Deposit: A Case Study from Shuitou Fluorite Deposit, Inner Mongolia, North China - Liang Wang; Shouting Zhang; Yi Fang; Li Tang (Journal of Earth Science, 2021)

Effect of Hydrological Connectivity on Soil Carbon Storage in the Yellow River Delta Wetlands of China - Jiuge Feng; Jinfeng Liang; Qianwei Li; Xiaoya Zhang; Yi Yue; Junqin Gao (Chinese Geographical Science, 2021)

Effects of poor plumage conditions on egg production, antioxidant status and gene expression in laying hens - Junying Li; Chengjie Zhang; Ruiyu Ma; Renrong Qi; Yi Wan; Wei Liu; Tao Zhao; Yan Li; Kai Zhan (Tropical Animal Health and Production, 2021)

Cold-induced Yes-associated-protein expression through miR-429 mediates the browning of white adipose tissue - Chenji Ye; Jinjie Duan; Xuejiao Zhang; Liu Yao; Yayue Song; Guangyan Wang; Qi Li; Biqing Wang; Ding Ai; Chunjiong Wang; Yi Zhu (Science China Life Sciences, 2021)

A highly selective and sensitive upconversion nanoprobe for monitoring hydroxyl radicals in living cells and the liver - Guangshun Yu; Na Feng; Dan Zhao; Hao Wang; Yi Jin; Dandan Liu; Zhenhua Li; Xinjian Yang; Kun Ge; Jinchao Zhang (Science China Life Sciences, 2021)

Correction to: P2Y12 receptor upregulation in satellite glial cells is involved in neuropathic pain induced by HIV glycoprotein 120 and 2',3'-dideoxycytidine - Zhihua Yi; Lihui Xie; Congfa Zhou; Huilong Yuan; Shuai Ouyang; Zhi Fang; Shanhong Zhao; Tianyu Jia; Lifang Zou; Shouyu Wang; Yun Xue; Bing Wu; et al. (Purinergic Signalling, 2021)

NGF-Induced Nav1.7 Upregulation Contributes to Chronic Post-surgical Pain by Activating SGK1-Dependent Nedd4-2 Phosphorylation - Bao-Wen Liu; Jin Zhang; Yi-Shun Hong; Ning-Bo Li; Yi Liu; Mi Zhang; Wen-Yao Wu; Hua Zheng; Angelika Lampert; Xian-Wei Zhang (Molecular Neurobiology, 2021)

Stoichiometric analysis of an arable crop–soil–microbe system after repeated fertilizer and compost application for 10 years - Yi Yang; Rongbo Ji; Hongyan Zhang; Peter Christie; Gu Feng; Xiaolin Li; Jingping Gai (Journal of Soils and Sediments, 2021)

Single or combined effects of dietary arabinoxylan-oligosaccharide and inulin on growth performance, gut microbiota, and immune response in Pacific white shrimp Litopenaeus vannamei - Yun Li; Wei Yuan; Yi Zhang; Hong Liu; Xilin Dai (Journal of Oceanology and Limnology, 2021)

MutagenPred-GCNNs: A Graph Convolutional Neural Network-Based Classification Model for Mutagenicity Prediction with Data-Driven Molecular Fingerprints - Shimeng Li; Li Zhang; Huawei Feng; Jinhui Meng; Di Xie; Liwei Yi; Isaiah T. Arkin; Hongsheng Liu (Interdisciplinary Sciences: Computational Life Sciences, 2021)

RING-finger protein 5 promotes hepatocellular carcinoma progression and predicts poor prognosis - Yi Zhang; Jie Li; Huayang Chen; Changmao Zhang; Song You; Yue Zhao; Xiaoning Lin; Yaqi Yu; Fei Fang; Ting Fang; Xiaomin Wang (Human Cell, 2021)

Gene expression pattern of trophoblast-specific transcription factors in trophectoderm by analysis of single-cell RNA-seq data of human blastocyst - Yajun Liu; Yi Zhang; Shiwen Li; Jinquan Cui (Functional & Integrative Genomics, 2021)

Air pollution and hospital outpatient visits for conjunctivitis: a time-series analysis in Tai’an, China - Renchao Chen; Jun Yang; Di Chen; Wen-jing Liu; Chunlin Zhang; Hao Wang; Bixia Li; Peng Xiong; Boguang Wang; Yi Wang; Shanshan Li; Yuming Guo (Environmental Science and Pollution Research, 2021)

Enhanced nitrous oxide emissions caused by atmospheric nitrogen deposition in agroecosystems over China - Yuyu Yang; Lei Liu; Feng Zhang; Xiuying Zhang; Wen Xu; Xuejun Liu; Yi Li; Zhen Wang; Yaowen Xie (Environmental Science and Pollution Research, 2021)

Magnetic graphene-based nanocomposites as highly efficient absorbents for Cr(VI) removal from wastewater - Xiuxiu Zhang; Guiyun Yi; Zhengting Zhang; Jia Yu; Haiyang Fan; Peng Li; Huihui Zeng; Baolin Xing; Lunjian Chen; Chuanxiang Zhang (Environmental Science and Pollution Research, 2021)

Effects of degradation succession of alpine wetland on soil organic carbon and total nitrogen in the Yellow River source zone, west China - Chun-ying Lin; Xi-lai Li; Jing Zhang; Hua-fang Sun; Juan Zhang; Hui-bang Han; Qi-hua Wang; Cheng-biao Ma; Cheng-yi Li; Yu-xing Zhang; Xue-qian Ma (Journal of Mountain Science, 2021)

Dedifferentiation of human epidermal melanocytes in vitro by long-term trypsinization - Ren-He Chen; Li Xiao; Ru-Zhi Zhang; Sheng-Yi Wang; Yue Li (Cell and Tissue Banking, 2021)

Whole-cell bioreporters for evaluating petroleum hydrocarbon contamination - Bo Jiang; Yizhi Song; Zengjun Liu; Wei E. Huang; Guanghe Li; Songqiang Deng; Yi Xing; Dayi Zhang (Critical Reviews in Environmental Science and Technology, 2021)

Small RNA Sequencing Analysis of Germinating Single-bud Seedcane Sett in Sugarcane - Kai-Chao Wu; Lin Xu; Zhi-Nian Deng; Tian Pang; Rong-Hua Zhang; Yi-Jie Li; Xiao-Yan Liu; Cheng-Feng Huang; Wen-Xian Qin; Jian-Feng Wei; Li-Ping Wei; Yang-Rui Li; et al. (Sugar Tech, 2021)

Cardiac Na+-Ca2+ exchanger 1 (ncx1h) is critical for the ventricular cardiomyocyte formation via regulating the expression levels of gata4 and hand2 in zebrafish - Liming Chu; Huimin Yin; Lei Gao; Li Gao; Yu Xia; Chiyuan Zhang; Yi Chen; Tingxi Liu; Jijun Huang; Kenneth R. Boheler; Yong Zhou; Huang-Tian Yang (Science China Life Sciences, 2021)

Using Composite Phenotypes to Reveal Hidden Physiological Heterogeneity in High-Altitude Acclimatization in a Chinese Han Longitudinal Cohort - Yi Li; Yanyun Ma; Kun Wang; Menghan Zhang; Yi Wang; Xiaoyu Liu; Meng Hao; Xianhong Yin; Meng Liang; Hui Zhang; Xiaofeng Wang; Xingdong Chen; et al. (Phenomics, 2021)
Altitude acclimatization is a human physiological process of adjusting to the decreased oxygen availability. Since several physiological processes are involved and their correlations are complicated, the analyses of single traits are insufficient in revealing the complex mechanism of high-altitude acclimatization. In this study, we examined these physiological responses as the composite phenotypes that are represented by a linear combination of physiological traits. We developed a strategy that combines both spectral clustering and partial least squares path modeling (PLSPM) to define composite phenotypes based on a cohort study of 883 Chinese Han males. In addition, we captured 14 composite phenotypes from 28 physiological traits of high-altitude acclimatization. Using these composite phenotypes, we applied k-means clustering to reveal hidden population physiological heterogeneity in high-altitude acclimatization. Furthermore, we employed multivariate linear regression to systematically model (Models 1 and 2) oxygen saturation (SpO 2 ) changes in high-altitude acclimatization and evaluated model fitness performance. Composite phenotypes based on Model 2 fit better than single trait-based Model 1 in all measurement indices. This new strategy of using composite phenotypes may be potentially employed as a general strategy for complex traits research such as genetic loci discovery and analyses of phenomics.

Loss of Dec1 prevents autophagy in inflamed periodontal ligament fibroblast - Shunichi Oka; Xiaoyan Li; Fengzhu Zhang; Nitesh Tewari; Il-Shin Kim; Chongchong Chen; Liangjun Zhong; Nobushiro Hamada; Yoshiyuki Oi; Makoto Makishima; Yi Liu; Ujjal K. Bhawal (Molecular Biology Reports, 2021)

First report of Scaevola taccada leaf spot caused by Lasiodiplodia hormozganensis in China - Shaogang Zhang; Meijiao Hu; Chao Zhao; Yi Wang; Min Li; Zhaoyin Gao; Chunxia Li; Jing Yu (Journal of Plant Pathology, 2021)

Gastrin-17 induces gastric cancer cell epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway - YaJie Li; Yan Zhao; Yi Li; XiaoYi Zhang; Chao Li; NiYa Long; XueShu Chen; LiYa Bao; JianJiang Zhou; Yuan Xie (Journal of Physiology and Biochemistry, 2021)

miR-708 and miR-335-3p Inhibit the Apoptosis of Retinal Ganglion Cells Through Suppressing Autophagy - Qiuli Zhang; Chang He; Ruizhuang Li; Yi Ke; Kaidi Sun; Jiaqi Wang (Journal of Molecular Neuroscience, 2021)

The role of MYB proto-oncogene like 2 in tamoxifen resistance in breast cancer - Xia Li; Xi Zhang; Cong-Cong Wu; Ping-Ping Li; Yi-Mou Fu; Li-Hua Xie; Shuang-Shuang Sun; Ying-Ying Zhou; Bao-Ling Zhu (Journal of Molecular Histology, 2021)

Studies of anticancer activity in vivo and in vitro behaviors of liposomes encapsulated iridium(III) complex - Yiying Gu; Haoyu Wen; Yuanyuan Zhang; Lan Bai; Yi Zhou; Huiwen Zhang; Li Tian; Jing Hao; Yunjun Liu (JBIC Journal of Biological Inorganic Chemistry, 2021)

Assisted selection of eating quality progeny of indica (O. sativa L. ssp. indica) and japonica (O. sativa L. ssp. japonica) hybrids using rice starch properties - Ting Mao; Zhan Zhang; Shan Jun Ni; Yi Zhou Zhao; Xin Li; Li Li Zhang; Yan Liu; Cheng Shun Zhong; He Huang; Shao Lin Wang; Xu Li (Genetic Resources and Crop Evolution, 2021)

Patterns of tree species richness in Southwest China - Shuangfei Lu; Siyi Zhou; Xiaojie Yin; Chao Zhang; Rongliang Li; Jiahui Chen; Dongxu Ma; Yi Wang; Zhexiu Yu; Yuheng Chen (Environmental Monitoring and Assessment, 2021)

Selenium Plays an Anti-Inflammatory Role by Regulation NLRP3 Inflammasome in Staphylococcus aureus-Infected Mouse Mammary Gland - Chong-Liang Bi; Shu-Jiu Zhang; Yi-Zhao Shen; Mirielle Pauline; Hui Li; He Tang (Biological Trace Element Research, 2021)

Genomic Organization and Transcriptional Regulation of Two Homologous Fucolectin Genes AjFTL-1 and AjFTL-2 in Apostichopus japonicus - Yina Shao; Jiahao Wang; Yi Zhang; Chenghua Li (Journal of Ocean University of China, 2021)

Geochronological Framework of Paleoproterozoic Intrusive Rocks and Its Constraints on Tectonic Evolution of the Liao-Ji Belt, Sino-Korean Craton - Jingsheng Chen; Zhongzhu Yang; Dexin Tian; Dehe Xing; Lidong Zhang; Fan Yang; Bin Li; Miao Liu; Yi Shi; Chao Zhang (Journal of Earth Science, 2021)

Inversion of IP-Affected TEM Responses and Its Application in High Polarization Area - Qingquan Zhi; Xiaohong Deng; Junjie Wu; Xiu Li; Xingchun Wang; Yi Yang; Jie Zhang (Journal of Earth Science, 2021)

Community structure of bacterioplankton and its relationship with environmental factors in the upper reaches of the Heihe River in Qinghai Plateau - Zhang Qian‐Qian; Jian Sheng‐Long; Li Ke‐Mao; Wu Zhen‐Bing; Guan Hong‐Tao; Hao Jin‐Wen; Wang Shu‐Yi; Lin Yao‐Yao; Wang Guo‐Jie; Li Ai‐Hua (Environmental Microbiology, 2021)
Summary Planktonic microorganisms play a key role in the biogeochemical processes of the aquatic system, and they may be affected by many factors. High‐throughput sequencing technology was used in this study to investigate and study the bacterioplankton community of water bodies in the upper reaches of the Heihe River Basin in Qinghai Plateau. Results showed that Proteobacteria, Firmicutes, Bacteroidetes and Actinobacteria are the predominant phyla in this river section, while the main genera are Thiomonas , Acidibacillus , Acidocella , Rhodanobacter , Acidithiobacter and Gallionella , which are autochthonous in the acid‐mine drainage. Additionally, total nitrogen, total phosphorus, permanganate index and pH are significantly correlated with the bacterioplankton abundance and are the main limiting factors for the spatial distribution of the bacterioplankton. PICRUSt inferred that the mainstream microbial assemblages had a higher abundance of KOs belong to metabolism of terpenoids and polyketides, while the tributary had higher abundance of KOs belong to the immune system. The relationship between bacterioplankton community composition and environmental factors in the Heihe River basin was discussed for the first time in this study, which provides a theoretical basis for the healthy, orderly development of the water environment in the Heihe River Basin.

Experimental evidence for long‐term coexistence of copiotrophic and oligotrophic bacteria in pelagic surface seawater - Yi Li; Zhi‐Bin Wang; Xi‐Ying Zhang; Yan‐Ru Dang; Lin‐Lin Sun; Wei‐Peng Zhang; Hui‐Hui Fu; Gui‐Peng Yang; Min Wang; Andrew McMinn; Xiu‐Lan Chen; Yin Chen; et al. (Environmental Microbiology, 2021)
Summary Most marine copiotrophic bacteria can produce extracellular enzymes to degrade biopolymers into bio‐available smaller solutes, while oligotrophic bacteria usually cannot. Bacterial extracellular enzymes and enzymatic products can be a common resource that could be utilized by both copiotrophs and oligotrophs; when present, oligotrophs may outcompete the enzyme‐producing copiotrophs. However, copiotrophs and oligotrophs consistently coexist in the ocean. How they maintain coexistence has still not been experimentally studied. In this study, the interaction and coexistence of a copiotroph and an oligotroph, isolated from the same surface seawater sample and utilizing the same proteinaceous substrate, were experimentally investigated. The copiotroph could secrete extracellular proteases to degrade and then utilize the proteinaceous substrate. The oligotroph was unable to utilize the proteinaceous substrate by itself, but could grow by using the hydrolysate amino acids. The copiotroph outcompeted the oligotroph by adsorbing the amino acids quickly and having a higher growth rate in the rich medium. The oligotroph survived by adapting to low concentration of nutrients. The copiotroph and oligotroph were able to maintain long‐term (up to 142 days) coexistence in the laboratory. This study indicates that differences in the utilization of different concentrations of nutrients can drive the coexistence of marine copiotrophs and oligotrophs.

Preparation, Characterization, and In Vitro Pharmacodynamics and Pharmacokinetics Evaluation of PEGylated Urolithin A Liposomes - Shengfu Yi; Cong Zhang; Junjie Hu; Yan Meng; Liang Chen; Huifan Yu; Shan Li; Guihong Wang; Guohua Zheng; Zhenpeng Qiu (AAPS PharmSciTech, 2021)

Three new steroidal saponins from the roots and rhizomes of Rohdea chinensis (Baker) N.Tanaka (synonym Tupistra chinensis Baker) - Bei Song; Wenli Huang; Yuze Li; Yangyang Zhang; Huawei Zhang; Yi Jiang; Chong Deng; Xiaomei Song; Jianli Liu (Natural Product Research, 2021)

Further data on the levels of emerging Fusarium mycotoxins in cereals collected from Tianjin, China - Xiaohui Lin; Qian Zhang; Yi Zhang; Jianping Li; Mingyue Zhang; Xiao Hu; Fengqin Li (Food Additives & Contaminants Part B-Surveillance, 2021)

Effects of Different Component Contents of Colistin Methanesulfonate on the Pharmacokinetics of Prodrug and Formed Colistin in Human - Ya-Xin Fan; Yuan-Cheng Chen; Yi Li; Ji-Cheng Yu; Xing-Chen Bian; Xin Li; Wan-Zhen Li; Bei-Ning Guo; Hai-Lan Wu; Xiao-Fen Liu; Yu Wang; Xiao-Yong Xu; et al. (Pharmaceutical Research, 2021)

Early-Life Multiple Sevoflurane Exposures Alleviate Long-term Anxiety-Like Behaviors in Mice via the proBDNF/ERK Pathway - Ru-Yi Luo; Cong Luo; Feng Zhong; Wei-Yun Shen; Hui Li; Yan-Ling Zhang; Ru-Ping Dai (Molecular Neurobiology, 2021)

Effects of different long-term cropping systems on phoD-harboring bacterial community in red soils - Xiaomei Gou; Yan Cai; Changquan Wang; Bing Li; Ruiping Zhang; Yi Zhang; Xiaoyan Tang; Qiang Chen; Jie Shen; Jianrui Deng; Xueyu Zhou (Journal of Soils and Sediments, 2021)

Improved control of Frankliniella occidentalis on greenhouse pepper through the integration of Orius sauteri and neonicotinoid insecticides - Qing-cai Lin; Hao Chen; Dirk Babendreier; Jin-ping Zhang; Feng Zhang; Xiao-yan Dai; Zuo-wen Sun; Zhao-peng Shi; Xiao-lin Dong; Guang-an Wu; Yi Yu; Li Zheng; et al. (Journal of Pest Science, 2021)

Identification of SHANK2 Pathogenic Variants in a Chinese Uygur Population with Schizophrenia - Han Zhang; Dong Wang; Jianhua Chen; Xiuli Li; Qizhong Yi; Yongyong Shi (Journal of Molecular Neuroscience, 2021)

Predicting water quality during urbanization based on a causality-based input variable selection method modified back-propagation neural network - Xinzi Wang; Kejia Wang; Jiamu Ding; Xinqi Chen; Yi Li; Wenlong Zhang (Environmental Science and Pollution Research, 2021)

Land use and land cover change within the Koshi River Basin of the central Himalayas since 1990 - Fang-di Xie; Xue Wu; Lin-shan Liu; Yi-li Zhang; Basanta Paudel (Journal of Mountain Science, 2021)

A real-time inertial-aided cycle slip detection method based on ARIMA-GARCH model for inaccurate lever arm conditions - Qingsong Li; Yi Dong; Dingjie Wang; Liang Zhang; Jie Wu (GPS Solutions, 2021)

Improving the observation and prediction capabilities for Arctic marine environment: from the perspective of Arctic Shipping - Hui Wang; Qizhen Sun; Lin Zhang; Xi Liang; Qinghua Yang; Na Liu; Chunhua Li; Qingsheng Liu; Bingrui Li; Qian Feng; Xiao Cheng; Yi Yu (Acta Oceanologica Sinica, 2021)

Tuberculosis relapse is more common than reinfection in Beijing, China - Yi Liu; Xu Xia Zhang; Jia Jia Yu; Chen Liang; Qing Xing; Cong Yao; Chuan You Li (Infectious Diseases, 2020)

No Fertile Island Effects or Salt Island Effects of Tamarix chinensis on Understory Herbaceous Communities Were Found in the Coastal Area of Laizhou Bay, China - Dayou Zhou; Weihua Guo; Mingyan Li; Franziska Eller; Cheyu Zhang; Pan Wu; Shijie Yi; Shuren Yang; Ning Du; Xiaona Yu; Xiao Guo (Wetlands, 2020)

Correction to: Long noncoding NONRATT021972 siRNA normalized abnormal sympathetic activity mediated by the upregulation of P2X7 receptor in superior cervical ganglia after myocardial ischemia - Guihua Tu; Lifang Zou; Shuangmei Liu; Bing Wu; Qiulan Lv; Shouyu Wang; Yun Xue; Chunping Zhang; Zhihua Yi; Xi Zhang; Guilin Li; Shangdong Liang (Purinergic Signalling, 2020)

Silencing of DsbA-L gene impairs the PPARγ agonist function of improving insulin resistance in a high-glucose cell model - Xuan Zhou; Jia-qi Li; Li-jie Wei; Meng-zhou He; Jing Jia; Jing-yi Zhang; Shao-shuai Wang; Ling Feng (Journal of Zhejiang University-SCIENCE B, 2020)

SUMOylation of Pdia3 exacerbates proinsulin misfolding and ER stress in pancreatic beta cells - Na Li; Xi Luo; Qilin Yu; Ping Yang; Zhishui Chen; Xinqiang Wang; Jipin Jiang; Jing Xu; Quan Gong; Decio L. Eizirik; Zhiguang Zhou; Jiajun Zhao; et al. (Journal of Molecular Medicine, 2020)

De novo mutation of cancer-related genes associates with particular neurodevelopmental disorders - Bin Li; Kuokuo Li; Di Tian; Qiao Zhou; Yali Xie; Zhenghuan Fang; Xiaomeng Wang; Tengfei Luo; Zheng Wang; Yi Zhang; Yijing Wang; Qian Chen; et al. (Journal of Molecular Medicine, 2020)

Effect on intestinal microbiota, bioaccumulation, and oxidative stress of Carassius auratus gibelio under waterborne cadmium exposure - Nan Wang; Zhengyao Guo; Yilin Zhang; Peijun Zhang; Jia Liu; Yi Cheng; Lei Zhang; Yuehong Li (Fish Physiology and Biochemistry, 2020)

Joint probability-based classifier based on vine copula method for land use classification of multispectral remote sensing data - Yunlong Zhang; Xuan Wang; Dan Liu; Chunhui Li; Qiang Liu; Yanpeng Cai; Yujun Yi; Zhifeng Yang (Earth Science Informatics, 2020)

Microbiota Analysis of Eggshells in Different Areas and During Different Storage Time by Non-cultural Methods - Yi Shi; Songwen Wu; Wenjuan Li; Dongli Liu; Guozhu Ma; Zheng Zhang; Lu Yuan; Huan Li; Siruo Zhang; Nosheen Mushtaq; Jiru Xu (Current Microbiology, 2020)

Topological changes in white matter connectivity network in patients with Parkinson’s disease and depression - Xiao Hu; Long Qian; Yaoyu Zhang; Yuanyuan Xu; Li Zheng; Yijun Liu; Xiangrong Zhang; Yi Zhang; Weiguo Liu (Brain Imaging and Behavior, 2020)

Aberration of Serum and Tissue N-Glycans in Mouse β1,4-GalT1 Y286L Mutant Variants - Ran Cao; Tian-Chan Zhang; Ya-Ran Chen; Cui Cao; Huan Chen; Yi-Fan Huang; Morihisa Fujita; Li Liu; Josef Voglmeir (Glycoconjugate Journal, 2020)

LncRNA A2M-AS1 lessens the injury of cardiomyocytes caused by hypoxia and reoxygenation via regulating IL1R2 - Xue-Lian Song; Fei-Fei Zhang; Wen-Jing Wang; Xin-Ning Li; Yi Dang; Ying-Xiao Li; Qian Yang; Mei-Jing Shi; Xiao-Yong Qi (Genes & Genomics, 2020)

2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Daniela Alioto; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Simon J. Anthony; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Tomáš Bartonička; et al. (Archives of Virology, 2020)

Falsigemmobacter faecalis gen. nov. sp. nov., isolated from faeces of Rhinopithecus roxellanae, and reclassification of Gemmobacter intermedius as Falsigemmobacter intermedius comb. nov - Guiding Li; Yi Jiang; Qinyuan Li; Xiu Chen; Longqian Jiang; Kun Zhang; Defeng An; Lei Lang; Li Han; Xueshi Huang; Chenglin Jiang (Archives of Microbiology, 2020)

Sulfide ore prospecting in carbon-containing stratum using comprehensive time-domain induced polarization and controlled-source audio-frequency magnetotellurics - Ren-Bin Sun; Li-Xia Chu; Gui-Bin Zhang; Qiu-Ming Cheng; Yun-Chuan Xiang; Bin Hu; Chang-Rong Zhang; Jian-Fu Li; Yi-Jun Zhao (Applied Geophysics, 2020)

Chemical composition, antimicrobial activity and antioxidant activity of Litsea cubeba essential oils in different months - Qi-Hui She; Wen-Shuang Li; Yuan-Yuan Jiang; Yi-Chao Wu; Yong-Hong Zhou; Li Zhang (Natural Product Research, 2020)

Could urinary ACE2 protein level help identify individuals susceptible to SARS-CoV-2 infection and complication? - Xiaotian Ni; Changqing Sun; Yaping Tian; Yanjie Huang; Tongqing Gong; Lan Song; Xing Yang; Kai Li; Nairen Zheng; Jianping Wang; Hongxing Wu; Ruoxian Zhang; et al. (Science China Life Sciences, 2020)

An Experimental and Analytical Research on the Evolution of Mining Cracks in Deep Floor Rock Mass - Juntao Chen; Jinhai Zhao; Shichuan Zhang; Yi Zhang; Fan Yang; Ming Li (Pure and Applied Geophysics, 2020)

Synthesis and molecular docking studies of novel pyrimidine derivatives as potential antibacterial agents - Xue-Qian Bai; Chun-Shi Li; Ming-Yue Cui; Ze-Wen Song; Xing-Yu Zhou; Chao Zhang; Yang Zhao; Tian-Yi Zhang; Tie-Yan Jiang (Molecular Diversity, 2020)

Grazing by microzooplankton and copepods on the microbial food web in spring in the southern Yellow Sea, China - Yuan Zhao; Yi Dong; Haibo Li; Shiquan Lin; Lingfeng Huang; Tian Xiao; Gerald Gregori; Li Zhao; Wuchang Zhang (Marine Life Science & Technology, 2020)
Assessment of microzooplankton and copepods grazing pressure on picoplankton is a key requirement for resolving the microbial food web efficiency. Although microzooplankton grazing on picoplankton has been extensively studied, the impact of microzooplankton on different groups of picoplankton, i.e., heterotrophic bacteria, Synechococcus and picoeukaryotes have rarely been compared. Furthermore, in the very few existing studies there is no consistent evidence of an enhancing or restraining effect of copepods on picoplankton. More studies are needed to improve our understanding of the influence of microzooplankton and copepod on picoplankton. Dilution incubations and copepod addition incubations were performed during a cruise to the southern Yellow Sea on May 16–29, 2007. The bulk grazing of microzooplankton and the calanoid copepod Calanus sinicus on phytoplankton, flagellates and picoplankton was estimated. Stations were divided into either eutrophic or oligotrophic according to the nutrient and biological parameters. Picoplankton comprised a large part of the diet of microzooplankton in the central oligotrophic area, while phytoplankton was the main food of microzooplankton in the coastal eutrophic area. In the central oligotrophic area, microzooplankton preferred grazing on Synechococcus . After copepod addition, ciliate abundance decreased while Synechococcus abundance increased (382%, 64% and 64% at three experimental stations, respectively), indicating strong grazing pressure of microzooplankton on Synechococcus . Our results suggest that Synechococcus might be an essential carbon source the planktonic food web in the oligotrophic waters of southern Yellow Sea.

Sleep deprivation aggravated lipopolysaccharide/d-galactosamine-induced acute liver injury by suppressing melatonin production - Lu Liu; Li Zhang; Longjiang Li; Mengting Chen; Zhe Wang; Yi Shen; Jiayi Huang; Ling Tang (Inflammation Research, 2020)

Antibacterial effect of Blumea balsamifera DC. essential oil against Haemophilus parasuis - Changliang He; Peiyi Yang; Lu Wang; Xiaolin Jiang; Wei Zhang; Xiaoxia Liang; Lizi Yin; Zhongqiong Yin; Yi Geng; Zhijun Zhong; Xu Song; Yuanfeng Zou; et al. (Archives of Microbiology, 2020)

Deinococcus detaillensis sp. nov., isolated from humus soil in Antarctica - Kun Zhang; Jing Zhu; Shuai Li; Manik Prabhu Narsing Rao; Ning-Mei Li; Ang-Yang Guo; Zhao Jiang; Qi-Yong Tang; Yi Wan; Zhi-Dong Zhang; Wen-Jun Li (Archives of Microbiology, 2020)

Sedimentary evidence and luminescence and ESR dating of Early Pleistocene high lake levels of Megalake Tengger, northwestern China - Fan Yuxin; Li Zhenjun; Yang Guangliang; Yi Shuangwen; Zhang Qingsong; Liu Wenhao; Mou Xuesong (Journal of Quaternary Science, 2020)
The timing of high lake‐level stands during the Late Pleistocene in western China remains controversial. Here we report new results from Megalake Tengger based on a study of palaeo‐shorelines and a drill core from Baijian Lake in the northwestern Tengger Desert. Multiple dating methods, based on luminescence signals (quartz optically stimulated luminescence, K‐feldspar post infrared‐infrared stimulated luminescence) and electron spin resonance signals of quartz, were used to date beach sands from palaeo‐shoreline profiles at altitudes of ~1310 m (+20 m above lake level), ~1320 m (+30 m) and ~1350 m (+60 m), and from the top 20 m of sandy sediments from the drill core obtained from the modern beach of Baijian Lake. The dating results show that high lake‐level stands associated with the previously reported Megalake Tengger (~1310–1320 m) occurred during the late Early to Middle Pleistocene, which is much earlier than previously reported. In addition, no geomorphological evidence of shorelines and sedimentary evidence from the drill core profile were found to support the previously reported Late Pleistocene lake levels. Our results indicate that the exact age of the previously reported ‘high lake level event’ in a large part of northwestern China during the Late Pleistocene needs to be re‐evaluated.

Latitudinal differences in early growth of largehead hairtail ( Trichiurus japonicus ) in relation to environmental variables - Peng Sun; Qi Chen; Caihong Fu; Yi Xu; Runlong Sun; Jianchao Li; Haiqing Yu; Chi Zhang; Yang Liu; Zhenjiang Ye; Yongjun Tian; Mikko Heino (Fisheries Oceanography, 2020)
Largehead hairtail ( Trichiurus japonicus ) in the China Seas shows an increasing catch trend, despite continued overexploitation, which could be attributed to improved recruitment as a result of strengthened early growth. To understand the early growth variability of largehead hairtail, we examined the linkages between early growth, as revealed by otolith microstructure, and the associated environmental variables over both spatial and temporal scales. Young‐of‐the‐Year largehead hairtail were collected from three regions in the Bohai, Yellow and East China Seas between 29° and 39° N. Daily increment widths of sagittal otoliths were measured and used as a proxy for somatic growth. We found two spawning cohorts, Spring‐ and Summer‐spawned cohorts, that showed latitudinal differences in both mean growth and growth pattern. The transition time from larval to juvenile stage was identified at around 40 days. Daily increment widths of two cohorts showed similar growth pattern in the first 40 days, while location had a marked effect on daily growth over 41–110 days. This suggests physiologically constrained growth pattern in larval stage, but more plastic growth subject to habitat‐specific influences in juvenile stage. The gradient forest analysis identified sea bottom temperature, vertical temperature gradient, and sea surface salinity, as the most important variables in determining early growth. Latitudinal differences in early growth pattern and their response to environmental variables suggest adaptive plasticity of early growth, which has notable implication for the management and sustainable utilization of this important but heavily exploited resource in the China Seas.

Clostridium butyricum : a promising probiotic confers positive health benefits in aquatic animals - Ngoc Tuan Tran; Zhongzhen Li; Hongyu Ma; Yueling Zhang; Huaiping Zheng; Yi Gong; Shengkang Li (Reviews in Aquaculture, 2020)
Clostridium butyricum is a bacterium of rod shape, strictly anaerobic, Gram‐positive and form spores. Short‐chain fatty acids, biofuel compounds and precursors of biomaterials (H 2 , butanol and 1,3‐propanediol) are produced by C. butyricum during the fermentation of carbohydrates and sugars. In humans and animals, although C. butyricum has been found to be associated with botulism in infant and necrotising enterocolitis in preterm neonates, some strains have been demonstrated to be beneficial as probiotics. In aquatic animals, the application of C. butyricum as a probiotic has been commonly considered. In this review, we described and documented what we knew about the isolation, identification, phenotypic and biochemical characteristics, safety, pathogenicity and the mechanisms of action of C. butyricum in the gastrointestinal tract of aquatic animals. The evidence on the roles that C. butyricum plays in improving growth performance, digestibility, survival rate, immune response, disease resistance and the structure of intestinal tract, as well as the modulation of gut commensal microbiota and metabolic disorders in aquatic animals, is summarised. Albeit the probiotic C. butyricum has been applied in aquaculture, and further research, such as the inter‐relationships between the probiotic and the immune system of the host and the possible application of C. butyricum as an alternative to antibiotic substitution for the prevention and treatment of diseases, is required for future detailed studies.

Two new compounds, Talaromycin A and B, isolated from an endophytic fungus, Talaromyces aurantiacus - Yi-Fei Zhang; Zhong-Duo Yang; Xing Yang; Li-Jun Yang; Xiao-Jun Yao; Zong-Mei Shu (Natural Product Research, 2020)

An Improved Model for Investigating Dual Effects of Vegetation Density Variations and Groundwater Level Fluctuations on Water Transport and Dissipation in Raised Field Wetlands - Yunlong Zhang; Xuan Wang; Dan Liu; Yujun Yi; Chunhui Li; Qiang Liu; Yanpeng Cai (Wetlands, 2020)

Liquiritin inhibits proliferation and induces apoptosis in HepG2 hepatocellular carcinoma cells via the ROS-mediated MAPK/AKT/NF-κB signaling pathway - Jia-Ru Wang; Tian-Zhu Li; Cheng Wang; Shu-Mei Li; Ying-Hua Luo; Xian-Ji Piao; Yu-Chao Feng; Yi Zhang; Wan-Ting Xu; Yu Zhang; Tong Zhang; Shi-Nong Wang; et al. (Naunyn-Schmiedeberg's Archives of Pharmacology, 2020)

Highly sensitive serological approaches for Pepino mosaic virus detection - Wan-qin He; Jia-yu Wu; Yi-yi Ren; Xue-ping Zhou; Song-bai Zhang; Ya-juan Qian; Fang-fang Li; Jian-xiang Wu (Journal of Zhejiang University-SCIENCE B, 2020)

Pretreatment with interleukin 35-engineered mesenchymal stem cells protected against lipopolysaccharide-induced acute lung injury via pulmonary inflammation suppression - Xiaoning Zhang; Zhiqiang Zhang; Mingyan Ju; Jiaci Li; Yaqing Jing; Yuxia Zhao; Chao Gu; Ming Dong; Guang Li; Yi Liu (Inflammopharmacology, 2020)

Occurrence and partitioning of brominated flame retardants (BFRs) in indoor air and dust: a 15-month case study in a test home - Jia-Qi Guo; Yong-feng Li; Li-Yan Liu; Chun-Yan Huo; Yu Sun; Wan-li Ma; Zi-feng Zhang; Yi-Fan Li (Environmental Science and Pollution Research, 2020)

Pre-symptomatic local brain activity and functional connectivity alterations in nasopharyngeal carcinoma patients who developed radiation encephalopathy following radiotherapy - You-ming Zhang; Jian-ming Gao; Hong Zhou; Li Li; Li-zhi Liu; Zai-de Han; Xiao-ping Yi; Wei-hua Liao (Brain Imaging and Behavior, 2020)

Cortical morphometry alterations in brain regions involved in emotional, motor-control and self-referential processing in patients with functional constipation - Chunxin Hu; Li Liu; Lei Liu; Junwang Zhang; Yang Hu; Wenchao Zhang; Yueyan Ding; Yuanyuan Wang; Zhida Zhang; Karen M. von Deneen; Long Qian; Huaning Wang; et al. (Brain Imaging and Behavior, 2020)

Adaptation and molecular evidence for convergence in decapod crustaceans from deep‐sea hydrothermal vent environments - Jianbo Yuan; Xiaojun Zhang; Yi Gao; Xiaoxi Zhang; Chengzhang Liu; Jianhai Xiang; Fuhua Li (Molecular Ecology, 2020)
Hydrothermal vents are unique deep‐sea environments exhibiting extreme temperature gradients and toxic concentrations of H 2 S that limit the growth of biological communities. Notably, some decapod crustaceans are the dominant organisms inhabiting these environments, and share similar phenotypic and physiological traits, such as white body coloration and chemosynthetic capacity. However, a lack of genomic information has precluded an understanding of these convergent phenotypes. Here, comparative transcriptomic analyses were performed in 14 decapod species, including four deep‐sea hydrothermal vent species and 10 shallow‐water relatives. Phylogenetic analysis suggested that the four deep‐sea species stemmed from different ancestors despite being geographically close, and therefore their similar traits were probably the product of convergent evolution rather than lineal inheritance. A total of 391 positively selected genes, 109 parallel substituted genes and 33 significantly expanded gene families were identified in the deep‐sea decapods. Among these, only the SNARE interactions in vesicular transport pathway was significantly enriched, with both positively selected genes and parallel substituted genes, suggesting that specific macromolecule transport might be a strong convergent evolution trait in deep‐sea decapods. Furthermore, many genes involved in protein synthesis, processing and energy metabolism were detected under convergent evolution, suggesting a role for adaptive evolution in association with a specific metabolic pathway in response to chemosynthetic nutrition patterns. Moreover, our study suggests that convergently evolved white body colour might have resulted from the contraction of the crustacyanin gene family and the low content of astaxanthin in the body of deep‐sea decapods. Therefore, this study provides valuable genetic evidence for convergent evolution in deep‐sea decapods.