Genome and transcriptome of Chinese medaka (Oryzias sinensis) and its uses as a model fish for evaluating estrogenicity of surface water - Yue Wang; Jilong Guo; Xiaojing Jia; Xiaozhe Luo; Ying Zhou; Xingtai Mao; Xiaolin Fan; Hongxia Hu; Hua Zhu; Chengxia Jia; Xuan Guo; Lan Cheng; et al. (Environmental Pollution, 2023)

Maximum displacement prediction of composite floor system under falling impact - Jing-Zhou Zhang; Guo-Qiang Li; Ying-Zhi Sun; Jing Sun; Zhi-Wei Yu; Ran Feng (Engineering Structures, 2023)

The preparation of higher performance solid form of DATNBI based on rapid in-situ solvate-mediated phase transition mechanism - Ying Wang; Dandan Han; Xiaoqing Zhou; Zhenqi Zhang; Junbo Gong; Hongzhen Li; Qi Zhang (Chemical Engineering Journal, 2023)

Core-shell catalysts for the elimination of organic contaminants in aqueous solution: A review - Yuerong Zhou; Yunhe Li; Yilong Hou; Ce Wang; Ying Yang; Jiangwei Shang; Xiuwen Cheng (Chemical Engineering Journal, 2023)

Synergic remediation of polycyclic aromatic hydrocarbon-contaminated soil by a combined system of persulfate oxidation activated by biochar and phytoremediation with basil: A compatible, robust, and sustainable approach - Xiaoying Li; Qiren Tan; Ying Zhou; Qincheng Chen; Peng Sun; Guoqing Shen; Li Ma (Chemical Engineering Journal, 2023)

Confining CoTe2-ZnTe heterostructures on petal-like nitrogen-doped carbon for fast and robust sodium storage - Ying Jiang; Feng Wu; Zhengqing Ye; Yaozong Zhou; Yan Chen; Yixin Zhang; Zekai lv; Li Li; Man Xie; Renjie Chen (Chemical Engineering Journal, 2023)

Investigation on the effectiveness of ventilation dilution on mitigating COVID-19 patients’ secondary airway damage due to exposure to disinfectants - Yifan Li; Yiran Lu; Ying Wang; Li Liu; Hao Zhou; Borong Lin; Zhiyong Peng; Yufeng Yuan (Building and Environment, 2023)

Outer membrane protein of OmpF contributes to swimming motility, biofilm formation, osmotic response as well as the transcription of maltose metabolic genes in Citrobacter werkmanii - Gang Zhou; Ying-Si Wang; Hong Peng; Hui-Zhong Liu; Jin Feng; Su-Juan Li; Ting-Li Sun; Cai-Ling Li; Qing-Shan Shi; Xiao-bao Xie (World Journal of Microbiology and Biotechnology, 2023)

IL-18BP Alleviates Anxiety-Like Behavior Induced by Traumatic Stress via Inhibition of the IL-18R-NLRP3 Signaling Pathway in a Mouse Model of Hemorrhagic Shock and Resuscitation - Li-Min Zhang; Dong-Xue Zhang; Rong-Xin Song; Jin-Meng Lv; Lu-Ying Wang; Zhi-You Wu; Hui-Tao Miao; Yan-Bo Zhou; Wei Zhang; Yue Xin; Yan Li (Molecular Neurobiology, 2023)

Sub-Cellular Distribution of Zinc in Different Vegetative Organs and Their Contribution to Grains Zinc Accumulation in Rice Under Different Nitrogen and Zinc Supply - Zunxin Wang; Xianyu Wang; Siqin Liu; Ying Yang; Yang Li; Siyuan Chen; Guangpeng Wang; Xincheng Zhang; Yuxiu Ye; Laibao Hu; Qing Zhou; Feibing Wang; et al. (Journal of Plant Growth Regulation, 2023)

Earthquake-induced impulsive release of water in the fractured aquifer system: Insights from the long-term hydrochemical monitoring of hot springs in the Southeast Tibetan Plateau - Jiao Tian; Xiaocheng Zhou; Yucong Yan; Miao He; Jingchao Li; Jinyuan Dong; Fengli Liu; Shupei Ouyang; Ying Li; Lei Tian; Yingchun Wang; Tianming Huang; et al. (Applied Geochemistry, 2023)

Dual-response and lysosome-targeted fluorescent probe for viscosity and sulfur dioxide derivatives - Feng Li; Bang-Zhao Zhou; Wen Yao; Shou-Kang Sun; Jun-Ying Miao; Bao-Xiang Zhao; Zhao-Min Lin (Analytica Chimica Acta, 2023)

Lipopolysaccharide induces inflammatory microglial activation through CD147-mediated matrix metalloproteinase expression - Chunyan Yao; Xiaoling Liu; Yan Tang; Chunmei Wang; Chenggang Duan; Xiaoyan Liu; Mingliang Chen; Yumeng Zhou; Enjie Tang; Ying Xiang; Yafei Li; Ailing Ji; et al. (Environmental Science and Pollution Research, 2022)

Purification and properties of a novel trypsin inhibitor from ginkgo fruits and its antiproliferative effect in triple-negative breast cancer cells - Xiaohui Zhao; Dayu Zhou; Shiliang Ma; Kexin Zheng; Ying Li; Bo Huang (Natural Product Research, 2022)

Golden 2-like transcription factor contributes to the major QTL against rice black-streaked dwarf virus disease - Xuejuan Li; Feng Lin; Chenyang Li; Linlin Du; Zhiyang Liu; Wenjuan Shi; Jianying Lv; Xiaoyan Cao; Ying Lan; Yongjian Fan; Yijun Zhou; Tong Zhou (Theoretical and Applied Genetics, 2022)

Correction to: COX-2/PGE2 Pathway Inhibits the Ferroptosis Induced by Cerebral Ischemia Reperfusion - Yunfei Xu; Ying Liu; Kexin Li; Dun Yuan; Shun Yang; Lin Zhou; Yao Zhao; Shuying Miao; Caihong Lv; Jie Zhao (Molecular Neurobiology, 2022)

Immunosenescence of T cells: a key player in rheumatoid arthritis - Yi Gao; Weiwei Cai; Ying Zhou; Yuhui Li; Jingwen Cheng; Fang Wei (Inflammation Research, 2022)

Wide distribution of the sad gene cluster for sub‐terminal oxidation in alkane utilizers - Chao‐Fan Yin; Ying Xu; Tao Li; Ning‐Yi Zhou (Environmental Microbiology, 2022)
Alkane constitutes major fractions of crude oils, and its microbial aerobic degradation dominantly follows the terminal oxidation and the sub‐terminal pathways. However, the latter one received much less attention, especially since the related genes were yet to be fully defined. Here, we isolated a bacterium designated Acinetobacter sp. strain NyZ410, capable of growing on alkanes with a range of chain lengths and derived sub‐terminal oxidation products. From its genome, a s econdary a lcohol d egradation gene cluster ( sad ) was identified to be likely involved in converting the aliphatic secondary alcohols (the sub‐terminal oxidation products of alkanes) to the corresponding primary alcohols by removing two‐carbon unit. On this cluster, sadC encoded an alcohol dehydrogenase converting the aliphatic secondary alcohols to the corresponding ketones; sadD encoded a Baeyer–Villiger monooxygenase catalysing the conversion of the aliphatic ketones to the corresponding esters; SadA and SadB are two esterases hydrolyzing aliphatic esters to the primary alcohols and acetic acids. Bioinformatics analyses indicated that the sad cluster was widely distributed in the genomes of probable alkane degraders, apparently coexisting (64%) with the signature enzymes AlkM and AlmA for alkane terminal oxidation in 350 bacterial genomes. It suggests that the alkane sub‐terminal oxidation may be more ubiquitous than previously thought.

Development of a pressure-retaining separation and transfer system for sediment and overlying seawater - Jin Guo; Qixiao Zhou; Yongqiang Ge; Haonan Li; Qiaoling Gao; Ying Wang; Yuan Lin; Jiawang Chen (Frontiers in Marine Science, 2022)
Methane leakage at the interface between sediment and overlying seawater is an important basis for gas hydrate exploration. Therefore, a transfer device with working pressure of 30MPa and corresponding scheme are proposed to separate and transfer the sediment and overlying water inside the sampler under the condition of pressure-retaining. Based on the pressure relief valve with adjustable threshold pressure, the device transfers the overlying water by compressing the internal volume and transfers the sediment by secondary sampling. The performance of transfer device is studied by simulation and experiment. Based on the coupled Eulerian-Lagrangian approach in the Abaqus, the secondary sampling was investigated, and the penetration resistance and coring rate of the secondary sampling tube are 141N and 86.2%, respectively. By using the hydraulic simulation software AMESim, the pressure fluctuation caused by the movement of the mechanism during the transfer process was studied, and the pressure fluctuation amplitude is within 0.89 MPa. Furthermore, the laboratory transfer tests were carried out under high pressure conditions, and meantime, the simulation results are verified. Under the working condition of 30MPa, the device can maintain a pressure loss of no more than 8.0% (2.4MPa) within two hours, maintain pressure fluctuations during the transfer process within 4.8% (1.44MPa), and ensure that the pressure in the culture kettle decreases by 4.7% relative to the pressure in the sampler after the transfer, which shows the feasibility of the device application.

Isobaric sampling apparatus and key techniques for deep sea macro-organisms: A brief review - Hao Wang; Jiawang Chen; Qixiao Zhou; Xiaohui Hu; Qiaoling Gao; Jin Guo; Ying Wang; Haonan Li (Frontiers in Marine Science, 2022)
The study of deep-sea fauna is one of the essential themes of marine scientific research. For all that, the biology of deep animals remains largely unknown, such as their behaviors, metabolic characteristics, and mechanisms of adaptation to the deep-sea environment. Obtaining samples in good condition is an essential prerequisite for these investigations. The isobaric samplers were created to keep the organisms as much as possible in the in-situ environment during recovery. This report reviews the history and the application of isobaric samplers for deep-sea animals established by researchers worldwide over the past hundred years. Also, the crucial technologies of isobaric samplers are analyzed and summarized, including pressure compensation, insulation, sealing, etc. Finally, prospects for the future development of isobaric sampling technologies from the aspects of high fidelity, function integration, and real-time communication and integration operation. This review can provide a reference for future design and optimization of fidelity samplers for deep-sea animals.

The first genome sequence of Phomopsis vexans: a fungal pathogen causing Phomopsis blight in eggplant - Zhou Heng; Qian You; Zhiliang Li; Baojuan Sun; Xiaowan Xu; Ying Li; Zhenxing Li; Hengming Wang; Chao Gong; Xiaomei Xu; Tao Li (Biologia, 2022)

Enhancing extracellular electron transfer through selective enrichment of Geobacter with Fe@CN-modified carbon-based anode in microbial fuel cells - Xiao-Long Cheng; Qiang Xu; Qian-Wen Yang; Rui-Rui Tian; Biao Li; Su Yan; Xue-Ying Zhang; Jun Zhou; Xiao-Yu Yong (Environmental Science and Pollution Research, 2022)

Investigation on the pollution release characteristics of subgrade base materials prepared by oil-based cutting thermal desorption residues - Xingchun Li; Ying Zhou; Hui Li; Feng Zhan; Yucheng Liu; Ziming Wang; Wenwen Tu (Environmental Science and Pollution Research, 2022)

The structures and applications of microbial chondroitin AC lyase - Xiao-Man Fan; Li-Jian Zhou; Jia-Ying Huang; Ye-Wang Zhang (World Journal of Microbiology and Biotechnology, 2022)

Release of Endogenous Brain-derived Neurotrophic Factor into the Lateral Entorhinal Cortex from the Paraventricular Thalamus Ameliorates Social Memory Deficits in a Mouse Model of Alzheimer’s Disease - Yun-Long Xu; Lin Zhu; Zi-Jun Chen; Xiao-Fei Deng; Pei-Dong Liu; Shan Li; Bing-Chun Lin; Chuan-Zhong Yang; Wei Xu; Kui-Kui Zhou; Ying-Jie Zhu (Neuroscience Bulletin, 2022)

Underlying mechanisms of epithelial splicing regulatory proteins in cancer progression - Ying Liu; Yiwen Li; Chengcheng Du; Shouxiang Kuang; Xuehao Zhou; Jinyu Zhang; Xiang Ao (Journal of Molecular Medicine, 2022)

Genetic variations in the bitter taste receptor gene TAS2R38 are related to cigarette smoking behavior in Han Chinese smokers - Fei-Yan Qi; Zhou-Hai Zhu; Meng Li; Ying Guan; Qi-Yuan Peng; She-Ming Lu; Zhi-Hua Liu; Ming-Feng Wang; Ming-Ming Miao; Zhang-Yu Chen; Xue-Mei Li; Jie Bai; et al. (Genes & Genomics, 2022)

HDAC5 inactivates CYR61-regulated CD31/mTOR axis to prevent the occurrence of preeclampsia - Peiyue Jiang; Xia Ying; Zhi Li; Ruoan Jiang; Jinling Zhou; Mengmeng Zhang; Xiaofu Yang; Xiaojun Zhu (Cell and Tissue Research, 2022)

Identification of thioredoxin genes and analysis of their expression under abiotic stresses in Medicago truncatula - Liugen Xu; Yong Zhou; Jie Cheng; Liqing Kang; Yuqi Qiang; Xuemei Yan; Yuhua Yan; Ying Tang; Yihua Wang; Hua Li; Jianbo Song (Acta Physiologiae Plantarum, 2022)

U-net Models Based on Computed Tomography Perfusion Predict Tissue Outcome in Patients with Different Reperfusion Patterns - Yaode He; Zhongyu Luo; Ying Zhou; Rui Xue; Jiaping Li; Haitao Hu; Shenqiang Yan; Zhicai Chen; Jianan Wang; Min Lou (Translational Stroke Research, 2022)

Immune responses to Vibrio vulnificus formalin‐killed vaccine and ghost vaccine in Scophthalmus maximus - Shun Zhou; Ying Li; Jingyuan Yi; Xujia Zheng; Qing Huang; Lin Su; Baoshan Guo; Zongrui Yang; Yunji Xiu (Journal of Fish Diseases, 2022)
In this research, Vibrio vulnificus formalin‐killed (FKCs) vaccine and ghost (VVGs) vaccine were successfully developed, and shown to prevent vibriosis of Scophthalmus maximus resulting from V. vulnificus. The antibody titre of FKCs and VVGs vaccine was 1: 2 8 and 1: 2 11 . The RPS of FKCs and VVGs vaccine was 60% and 80%. In order to improve the understanding of vaccine protection mechanism, transcriptome data was used to analyse the immune response of S. maximus infected with V. vulnificus after vaccination with FKCs and VVGs vaccine. In the SmCon and SmIV groups, a series of innate immune‐related genes were upregulated (such as, TLR5, Tp12, AP‐1 and IL‐1β) or downregulated (such as, CASP6 and CASP8), which suggested that the immune protection mechanism induced by inactivated vaccine was similar to that of autoimmune response. In the SmIV and SmGho group, a number of innate and adaptive immune‐related genes (such as, STAT1, IFN‐γ and MHC Ia) were activated, in which the expression of these genes was higher in SmGho, and VVGs vaccine induced stronger innate and acquired immune responses. In conclusion, the results lay a foundation for further study on the molecular mechanisms of immune protection induced by VVGs vaccine and FKCs vaccine.

Lasiodiplodia theobromae protein LtScp1 contributes to fungal virulence and protects fungal mycelia against hydrolysis by grapevine chitinase - Junbo Peng; Xinghong Li; Yonghua Li; Wei Zhang; Ying Zhou; Jiye Yan (Environmental Microbiology, 2022)
The LysM proteins have been reported to be important for the virulence and host immunity suppression in herbaceous plant pathogens, whereas far less information is documented in the woody plant pathogen Lasiodiplodia theobromae . To investigate the functional mechanism of LysM protein in L. theobromae , one gene LtScp1 was cloned and characterized detailedly in the current study. Transcription profiling revealed that LtScp1 was highly expressed at the infectious stages. Compared to wild type, overexpression and silencing of LtScp1 in L. theobromae led to significantly increased and decreased lesion areas, respectively. Moreover, LtScp1 was determined to be a secreted protein via a yeast signal peptide trapping system. Interestingly, LtScp1 was confirmed to be modified by the N ‐glycosylation, which is necessary for the homodimerization of LtScp1 molecules. Furthermore, it was found that LtScp1 interacted with the grapevine chitinase VvChi4 and interfered the ability of VvChi4 to bind chitin. Collectively, these results suggest that LtScp1 functions as a virulence factor to protect the fungus from degradation during the infection.

Complete mitochondrial genomes of Thyreophagus entomophagus and Acarus siro (Sarcoptiformes: Astigmatina) provide insight into mitogenome features, evolution, and phylogeny among Acaroidea mites - Yu Fang; Mingzhong Sun; Ying Fang; Zetao Zuo; Luyao Liu; Lingmiao Chu; Lan Ding; Caixiao Hu; Feiyan Li; Renrui Han; Xingquan Xia; Shulin Zhou; et al. (Experimental and Applied Acarology, 2022)

Elder people can be more susceptible to the association between short-term ambient air pollution and sleep disorder outpatient visits: a time-series study - Yu-Meng Zhou; Shu-Jie An; Yi Cao; Chen Xu; Xiao-Ling Liu; Chun-Yan Yao; Xiang Li; Na Wu; Cheng-Ying Li; Long Wu; Ya-Fei Li; Ai-Ling Ji; et al. (Environmental Science and Pollution Research, 2022)

Negative air ion exposure ameliorates depression-like behaviors induced by chronic mild stress in mice - Yun-Qing Hu; Ting-Ting Niu; Jian-ming Xu; Li Peng; Qing-Hua Sun; Ying Huang; Ji Zhou; Yu-Qiang Ding (Environmental Science and Pollution Research, 2022)
The presence of negative air ions (NAI) is suggested to be a beneficial factor in improving psychological status and used in treating depression as an alternative approach. However, more biological evidence from animal models is needed to ensure the effects of NAI on the mood regulation, through which can facilitate identification of possible underlying mechanisms. In this study, the chronic mild stress (CMS) protocol was used to induce depressive-like behaviors in mice, and the effects of NAI exposure on CMS-induced depression-like behaviors were examined. Thirty-day NAI exposure prevented the CMS-induced depression-like behaviors as shown by the restoration of sucrose preference and reduced immobility time in the tail suspension test. In addition, the elevation of serous corticosterone was present in CMS-treated mice but not existed in those with the NAI exposure. Furthermore, we observed altered ratios of some cytokines secreted by type 1 T helper (Th1) cells and Th2 cells in CMS-treated mice, but it could be restored after NAI exposure. In conclusion, NAI intervention is able to ameliorate CMS-induced depression-like behaviors in mice, and this effect is associated with the alteration of corticosterone and functional rebalance between Th1 and Th2 cells.

Dyadobacter diqingensis sp. nov., isolated from Baima snow mountain of Diqing Tibetan Autonomous Prefecture in Yunnan province, south-west China - Lei Ran; Man Peng; Wei-Qun Wang; Yu-Zhou Feng; Juan Wang; Yu Wang; Cui-Ying Li; Xin-Xing Liu; Wei-Xun Chunyu; Shu-Kun Tang (Archives of Microbiology, 2022)

A lens-shaped, cold-core anticyclonic surface eddy in the northern South China Sea - Yongfeng Qi; Huabin Mao; Yan Du; Xianpeng Li; Zhou Yang; Ke Xu; Ying Yang; Wanxuan Zhong; Fuchang Zhong; Linghui Yu; Huanlin Xing (Frontiers in Marine Science, 2022)
Typically, compared with the normal ocean, an anticyclonic eddy has higher sea surface temperature (SST), greater surface mixed-layer depth (MLD), and a bowl-shaped structure under the action of geostrophy. This study is the first to report an abnormal anticyclonic eddy characterized by a lens-shaped structure, cold core, and shallower MLD, which were observed in situ in the northern South China Sea (SCS) in September 2021. The SST at core of the anticyclonic eddy was 0.4°C lower than that in its peripheral region. The MLD at the center of the eddy was about half of that outside the eddy. Below the surface mixed layer, a lens-shaped structure containing relatively well-mixed water was observed between the two high-gradient layers. Within this lens-shaped structure, the isothermal layers were stretched, but accompanied by water mixing that was about one third of that at the upper and lower bounds of the structure. This eddy originated from a Kuroshio Current intrusion in late October 2020 and died in November 2021, such that its lifespan exceeded 1 year. The shedding of the Kuroshio Loop into the SCS under strong air–sea interactions under continuous sea surface cooling in winter was considered a key mechanism for the generation of the cold core of the eddy. The lens-shaped structure formed below the surface mixed layer and was maintained through geostrophic balance by the subsurface maximum speeds of the Kuroshio Current intrusion (50–100 m), thereby forming a shallower MLD in the eddy center. The subsurface speed maximum within the eddy was also observed by a shipborne acoustic Doppler current profiler at 10 months after its formation, confirming the hypothesized mechanism. This type of abnormal anticyclonic may be a common phenomenon in the northern SCS and has potential implications for the local biogeochemistry, local heat budget, and regional oceanic models.

Reduced Hypoxia Tolerance and Altered Gill Morphology at Elevated Temperatures May Limit the Survival of Tilapia (GIFT, Oreochromis niloticus) under Global Warming - Yan Zhou; Yanjie Zhang; Shang Wei; Wei Li; Wenhao Li; Zhichao Wu; Shouwen Jiang; Ying Lu; Qianghua Xu; Liangbiao Chen (Fishes, 2022)
Nile tilapia (Oreochromis niloticus) is one of the most important food fishes in global aquaculture. The optimal rearing temperature for Nile tilapia is 27–30 °C; however, in some Asian breeding areas, such as south China, water temperatures in summer frequently exceed 35 °C for several days. Potential effects of long-term exposure to high temperatures on the survival and metabolism of tilapia are unclear. In this study, genetically improved farmed tilapia, age six weeks, were exposed to water temperatures of 28, 32, and 36 °C for 15 weeks. Mean survival rates and tolerance to hypoxia were significantly reduced, and respiratory rates were increased in fish reared at 36 °C, compared to the 28 and 32 °C treatments (p

Neuroprotection of Oral Edaravone on Middle Cerebral Artery Occlusion in Rats - Li-Qin Zhao; Ankit Parikh; Yun-Xia Xiong; Qing-Yan Ye; Ying-Guo; Xin-Fu Zhou; Hai-Yun Luo (Neurotoxicity Research, 2022)

P2X7/P2X4 Receptors Mediate Proliferation and Migration of Retinal Microglia in Experimental Glaucoma in Mice - Meng-Xi Xu; Guo-Li Zhao; Xin Hu; Han Zhou; Shu-Ying Li; Fang Li; Yanying Miao; Bo Lei; Zhongfeng Wang (Neuroscience Bulletin, 2022)

Evaluating the corresponding relationship between the characteristics of resource utilization and the level of urbanization: a case study in Chengdu-Chongqing Economic Circle, China - Ying Zhou; Zhuolu Li; Yuan Chen; Wei Wei (Environmental Science and Pollution Research, 2022)

Halomonas faecis sp. nov., a halophilic bacterium isolated from human faeces - Zhu-Xiang Liu; Jin-Hua Chen; Ling-Ling Yang; Yu-Zhou Feng; Li-Ying Deng; Jian-Wu He; Shu-Kun Tang; Yi-Guang Chen (Extremophiles, 2022)

Two new bioactive secondary metabolites from the endophytic fungus Talaromyces assiutensis JTY2 - Ying-Li Li; Ji-Ling Yi; Jin Cai; Xue-Ming Zhou; Li Chen; Xin Zhuo; Xin-Yi Lai (Natural Product Research, 2022)

Soil Se Characteristics and the Possible Influencing Factors in Lanshan District of Linyi, Shandong, China - Ziyuan Hu; Fuquan Li; Yongshuai Zhang; Liangyu Zhou; Lei Guo; Youchun Duan; Qinghai Deng; Xuewenyu Wang; Ying Zhao; Qiao Chen (Water, Air, & Soil Pollution, 2022)

Three-Dimensional DC Anisotropic Resistivity Modeling Using a Method in the Mixed Space–Wavenumber Domain - Jiaxuan Ling; Shikun Dai; Yinming Zhou; Qingrui Chen; Ying Zhang; Kun Li (Pure and Applied Geophysics, 2022)

Study on Preparation and Properties of Red Mud Magnesium Oxysulfate Cement Foamed Concrete - Wei-Ying Li; Jun-Bo Zhou; Zhi-Yuan Zhang; Xin-Xiong Zhu (Bulletin of Environmental Contamination and Toxicology, 2022)

Nile tilapia TRIM39 recruits I3K413 and I3KL45 as adaptors and is involved in the NF‐κB pathway - Feng‐ying Gao; Xin Zhou; Mai‐xin Lu; Miao Wang; Zhi‐gang Liu; Jiang‐meng Cao; Xiao‐li Ke; Meng‐meng Yi (Journal of Fish Biology, 2022)
Tripartite motif (TRIM) proteins play a regulatory function in cancer, cell apoptosis and innate immunity. To understand the role of TRIM39 in Nile tilapia ( Oreochromis niloticus ), TRIM39 cDNA was isolated. The total length of TRIM39 cDNA was 5025 bp. The deduced OnTRIM39 protein contains 549 amino acids and has conserved domains of the TRIM family, which are the RING, B‐box, coiled‐coil and PRY‐SPRY domains. OnTRIM39 mRNA was widely expressed in various tissues. After challenge with Streptococcus agalactiae and stimulation with polyinosinic polycytidylic acid [poly (I:C)] and lipopolysaccharides (LPS), the amount of OnTRIM39 transcript was changed in various tested tissues. OnTRIM39 overexpression increased NF‐κB activity. OnTRIM39 was present in the cytoplasm. Mass spectrometry of proteins pulled down with recombinant OnTRIM39 showed that 250 proteins potentially interact with OnTRIM39. The authors selected I3K4I3 from the 250 candidate proteins to verify its interaction with TRIM39. They also selected I3KL45, a member of the same 14‐3‐3 protein family, to verify its interaction with TRIM39. The results of pull‐down assays showed that OnTRIM39 interacted with both I3K413 and I3KL45. These results contribute to further study of the innate immune mechanism of tilapia.

LncRNA TARID induces cell proliferation through cell cycle pathway associated with coronary artery disease - Zheng Cheng; Yonghong Zhang; Yang Zhuo; Jie Fan; Ying Xu; Mengmeng Li; Hao Chen; Li Zhou (Molecular Biology Reports, 2022)

Exploring the cause of the dual allosteric targeted inhibition attaching to allosteric sites enhancing SHP2 inhibition - Ma Yangchun; Yang WenYu; Zhou Liang; Li LiPeng; Wu JingWei; Li WeiYa; Du Shan; Ma Ying; Wang RunLing (Molecular Diversity, 2022)

An Energy-Rich Phosphate Compound Enhances the Growth of Lettuce Through the Activation of Photosynthesis, Growth, and Induced Systemic Resistance–Related Processes - Chaowei Zhou; Shanshan Li; Yilin Zheng; Peng Lei; Yong Chen; Hanjie Ying; Nan Gao (Journal of Soil Science and Plant Nutrition, 2022)

Hexavalent Chromium Causes Apoptosis and Autophagy by Inducing Mitochondrial Dysfunction and Oxidative Stress in Broiler Cardiomyocytes - Hao Li; Jingjing Shi; Haihang Gao; Xiaoqi Yang; Yang Fu; Yuxuan Peng; Ying Xia; Donghai Zhou (Biological Trace Element Research, 2022)

Comparison of different inversion methods of D-T2 two-dimensional nuclear magnetic resonance logging and applicability analysis - Cheng-Lin Li; Mao-Jin Tan; Ke-Wen Wang; Feng Zhou; Ying-Ming Liu; Hai-Tao Zhang; Li-Zhi Xiao (Applied Geophysics, 2022)

New oxindole alkaloids with selective osteoclast inhibitory activity from Gelsemium elegans - Xin Wei; Xiao-Teng Huang; Li-Yan Zhang; Xin-Yue Hu; Wei Zhang; Yong-Qiang Zhou; Hao-Fei Yu; Cai-Feng Ding; Lan-Chun Zhang; Xia Liu; Ying Zhou (Natural Product Research, 2022)

Exogenous artificial DNA forms chromatin structure with active transcription in yeast - Jianting Zhou; Chao Zhang; Ran Wei; Mingzhe Han; Songduo Wang; Kaiguang Yang; Lihua Zhang; Weigang Chen; Mingzhang Wen; Cheng Li; Wei Tao; Ying-Jin Yuan (Science China Life Sciences, 2022)
Yeast artificial chromosomes (YACs) are important tools for sequencing, gene cloning, and transferring large quantities of genetic information. However, the structure and activity of YAC chromatin, as well as the unintended impacts of introducing foreign DNA sequences on DNA-associated biochemical events, have not been widely explored. Here, we showed that abundant genetic elements like TATA box and transcription factor-binding motifs occurred unintentionally in a previously reported data-carrying chromosome (dChr). In addition, we used state-of-the-art sequencing technologies to comprehensively profile the genetic, epigenetic, transcriptional, and proteomic characteristics of the exogenous dChr. We found that the data-carrying DNA formed active chromatin with high chromatin accessibility and H3K4 tri-methylation levels. The dChr also displayed highly pervasive transcriptional ability and transcribed hundreds of noncoding RNAs. The results demonstrated that exogenous artificial chromosomes formed chromatin structures and did not remain as naked or loose plasmids. A better understanding of the YAC chromatin nature will improve our ability to design better data-storage chromosomes.

A large-scale obliquely inclined bedding rockslide triggered by heavy rainstorm on the 8th of July 2020 in Shiban Village, Guizhou, China - Haibing Yu; Changdong Li; Jia-Qing Zhou; Xiaoping Gu; Ying Duan; Liufeng Liao; Wenqiang Chen; Yinbin Zhu; Jingjing Long (Landslides, 2022)

Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry - Shiyou Zhu; Ying Liu; Zhuo Zhou; Zhiying Zhang; Xia Xiao; Zhiheng Liu; Ang Chen; Xiaojing Dong; Feng Tian; Shihua Chen; Yiyuan Xu; Chunhui Wang; et al. (Science China Life Sciences, 2022)

Altered Connectedness of the Brain Chronnectome During the Progression to Alzheimer’s Disease - Maryam Ghanbari; Zhen Zhou; Li-Ming Hsu; Ying Han; Yu Sun; Pew-Thian Yap; Han Zhang; Dinggang Shen (Neuroinformatics, 2022)

A Study of Uniaxial Acoustic Emission Creep of Salt Rock Based on Improved Fractional-Order Derivative - Fei Wu; Xuhui Zhou; Peng Ying; Cunbao Li; Zheming Zhu; Jie Chen (Rock Mechanics and Rock Engineering, 2022)

Associations of CXCL12 polymorphisms with clinicopathological features in breast cancer: a case-control study - Shuai Lin; Yi Zheng; Meng Wang; Linghui Zhou; Yuyao Zhu; Yujiao Deng; Ying Wu; Dai Zhang; Na Li; Huafeng Kang; Zhijun Dai (Molecular Biology Reports, 2022)
Background Previous studies suggested that CXCL12 was involved in the development, metastasis, and invasion of breast cancer, and genetic variants were associated with the diagnosis and prognosis of patients with breast cancer. The present study was aimed to assess the relationships between CXCL12 polymorphisms (rs1801157, rs2297630, and rs2839693) and susceptibility and clinicopathological features of breast cancer. Methods A case-control study was conducted in 434 breast cancer patients and 450 health controls. Student t -test and chi-square test were used to analyze the differences of age distribution and genotype frequencies between the two groups. Correlations between polymorphisms and clinical parameters were also assessed by chi-square test. The potential effects of the three polymorphisms on CXCL12 were investigated by the public database. Results A statistical association was found between CXCL12 rs1801157 polymorphism and breast cancer risk, possibility of metastasis, and estrogen receptor status. Patients with rs2839693 C/T or C/T-T/T genotypes were more likely to be progesterone receptor-negative. However, no associations of rs2297630 polymorphism with breast cancer risk or any clinicopathological characteristics were observed. In addition, rs2297630 affected the splicing quantitative trait loci of CXCL12 in the subcutaneous fat, rs2839693 polymorphism affected the splicing quantitative trait loci of CXCL12 in the human breast mammary tissues. Conclusions Those results indicated that CXCL12 polymorphisms might be potential diagnostic indicators, and more investigation is needed in the future.

COX-2/PGE2 Pathway Inhibits the Ferroptosis Induced by Cerebral Ischemia Reperfusion - Yunfei Xu; Ying Liu; Kexin Li; Dun Yuan; Shun Yang; Lin Zhou; Yao Zhao; Shuying Miao; Caihong Lv; Jie Zhao (Molecular Neurobiology, 2022)

Optimizing nitrogen fertilizer application under reduced irrigation strategies for winter wheat of the north China plain - Ying Liu; Meikun Han; Xiaonan Zhou; Wei Li; Chenghang Du; Yitao Zhang; Yinghua Zhang; Zhencai Sun; Zhimin Wang (Irrigation Science, 2022)

Circular RNA circ_0008934 promotes hepatocellular carcinoma growth and metastasis through modulating miR-1305/TMTC3 axis - Jia-Xi Li; Jin-Jiang Wang; Zhou-Feng Deng; Hao Zheng; Chun-Mei Yang; Ying Yuan; Cheng Yang; Fang-Fang Gu; Wei-Qi Wu; Guang-Lei Qiao; Li-Jun Ma (Human Cell, 2022)

Evaluation of EpCAM-specific exosomal lncRNAs as potential diagnostic biomarkers for lung cancer using droplet digital PCR - Xintong Shen; Yifeng Yang; Yinfeng Chen; Chengwei Zhou; Xiaodong Zhao; Nan Li; Chengtao Lou; Ying Huang; Dongmei Tian; Yan Shen; Xiaodan Meng (Journal of Molecular Medicine, 2022)

Enhanced photosynthetic nitrogen use efficiency and increased nitrogen allocation to photosynthetic machinery under cotton domestication - Zhang-Ying Lei; Heng Wang; Ian J. Wright; Xin-Guang Zhu; Ülo Niinemets; Zi-Liang Li; Dong-Sheng Sun; Ning Dong; Wang-Feng Zhang; Zhong-Li Zhou; Fang Liu; Ya-Li Zhang (Photosynthesis Research, 2021)

Antimicrobial Natural Products Produced by Soil-Derived Fungus Penicillium cremeogriseum W1-1 - Xu-Yan Sang; Zhao-Jie Wang; Ya-Bin Yang; Yong-Liang Wang; Mei-Ling Xiang; Dou-Ying Zhu; Ying Zhou; Xiao-Dong Luo; Li-Xing Zhao (Indian Journal of Microbiology, 2021)

Effects of food quantity on aggression and monoamine levels of juvenile pufferfish (Takifugu rubripes) - Yu Hu; Ying Liu; Cheng Zhou; Haixia Li; Jize Fan; Zhen Ma (Fish Physiology and Biochemistry, 2021)

Occurrence, source apportionment, and carcinogenic risk assessment of polycyclic aromatic hydrocarbons in urban road dusts in Shanghai - Xue-Tong Wang; Rui Fu; Ying Zhou; Cheng-Lin Wang; Guo-Fa Ren; Xiao-Li Wang; Hui Li (Environmental Science and Pollution Research, 2021)

Mineralogical characteristics and sedimentary envrionment significance of water-insoluble minerals in potash deposits of Vientiane Basin of Laos - Tang Qi-liang; Zhang Xi-ying; Miao Wei-liang; Ma Hai-zhou; Li Yong-shou; Li Wen-xia; Yuan Xiao-long (Carbonates and Evaporites, 2021)

Long-term changes of water acidity in an intact forested watershed in south China - Xiao-dong Liu; Ying-jie Feng; Qi-feng Mo; Guo-wei Chu; Yue-lin Li; Qian-mei Zhang; Wei-qiang Zhang; Xian-hua Gan; Qing Zhou (Journal of Mountain Science, 2021)

Evaluation of four artificial diets on demography parameters of Neoseiulus barkeri - Ya-Ying Li; Jin-Ge Yuan; Ming-Xiu Liu; Zi-Hui Zhang; Hai-Wei Zhou; Huai Liu (BioControl, 2021)

Rapid visual detection of Aeromonas salmonicida by loop‐mediated isothermal amplification with hydroxynaphthol blue dye - Shun Zhou; Qing Huang; Mingming Yu; Ying Li; Xujia Zheng; Yunji Xiu (Journal of Fish Diseases, 2021)
To make crucial prevention, reduce fish losses and minimize the economic damage of diseases on the fish farm owners, a rapid detection of fish pathogens is mandatory. In this study, a loop‐mediated isothermal amplification assay combined with hydroxynaphthol blue dye (LAMP‐HNB) was developed and used for the rapid detection of Aeromonas salmonicida that caused significant economic losses in fish farming. Firstly, a pair of outer and inner primers specific for conserved fragment of vapA gene in A. salmonicida were designed and synthesized. Secondly, by optimizing the reaction conditions including reaction temperature, time, Mg 2+ concentration, dNTP concentration and primer ratio, a LAMP‐HNB assay was successfully established for the detection of A. salmoncida . Thirdly, the assay showed good specificity with no false‐positive and false‐negative results, and good sensitivity with the detection limit of 3.077 × 10 –6 ng/μl, which was 10 2 times more sensitive than the conventional PCR. Finally, the LAMP‐HNB assay was validated by the fish samples inoculated with different concentrations of A. salmoncida . This is the first development of rapid visual detection of A. salmonicida based on LAMP‐HNB assay, which has great application prospect and market for diagnostic testing, health certification and active surveillance programmers.

Two new phenolic glycosides with anti-complementary activity from the roots of Sanguisorba officinalis L - Rongshen Wang; Jinfeng Sun; Mei Jin; Chao Ye; Jiaming Wang; Long Jin; Ying Jie Ma; Wei Zhou; Gao Li (Natural Product Research, 2021)

Terpenoid indole alkaloid biosynthesis in Catharanthus roseus: effects and prospects of environmental factors in metabolic engineering - Yongliang Liu; Barunava Patra; Sanjay Kumar Singh; Priyanka Paul; Yan Zhou; Yongqing Li; Ying Wang; Sitakanta Pattanaik; Ling Yuan (Biotechnology Letters, 2021)
Plants synthesize a vast array of specialized metabolites that primarily contribute to their defense and survival under adverse conditions. Many of the specialized metabolites have therapeutic values as drugs. Biosynthesis of specialized metabolites is affected by environmental factors including light, temperature, drought, salinity, and nutrients, as well as pathogens and insects. These environmental factors trigger a myriad of changes in gene expression at the transcriptional and posttranscriptional levels. The dynamic changes in gene expression are mediated by several regulatory proteins that perceive and transduce the signals, leading to up- or down-regulation of the metabolic pathways. Exploring the environmental effects and related signal cascades is a strategy in metabolic engineering to produce valuable specialized metabolites. However, mechanistic studies on environmental factors affecting specialized metabolism are limited. The medicinal plant Catharanthus roseus (Madagascar periwinkle) is an important source of bioactive terpenoid indole alkaloids (TIAs), including the anticancer therapeutics vinblastine and vincristine. The emerging picture shows that various environmental factors significantly alter TIA accumulation by affecting the expression of regulatory and enzyme-encoding genes in the pathway. Compared to our understanding of the TIA pathway in response to the phytohormone jasmonate, the impacts of environmental factors on TIA biosynthesis are insufficiently studied and discussed. This review thus focuses on these aspects and discusses possible strategies for metabolic engineering of TIA biosynthesis. Purpose of work Catharanthus roseus is a rich source of bioactive terpenoid indole alkaloids (TIAs). The objective of this work is to present a comprehensive account of the influence of various biotic and abiotic factors on TIA biosynthesis and to discuss possible strategies to enhance TIA production through metabolic engineering.

Spatiotemporal change of vegetation coverage recovery and its driving factors in the Wenchuan earthquake-hit areas - Xiao-fei Sun; Lin-guo Yuan; Ying-zhi Zhou; Huai-yong Shao; Xian-feng Li; Ping Zhong (Journal of Mountain Science, 2021)

Echinicola salinicaeni sp. nov., a novel bacterium isolated from saltern mud - Han Zhao; Chun-Yi Song; Rui Yin; Yan-Jun Yi; Shuai-Ting Yun; Ying-Xiu Li; Yan-Xia Zhou (Antonie van Leeuwenhoek, 2021)

Microbial ecology of sulfur cycling near the sulfate–methane transition of deep‐sea cold seep sediments - Wen‐Li Li; Xiyang Dong; Rui Lu; Ying‐Li Zhou; Peng‐Fei Zheng; Dong Feng; Yong Wang (Environmental Microbiology, 2021)
Summary Microbial sulfate reduction is largely associated with anaerobic methane oxidation and alkane degradation in sulfate–methane transition zone (SMTZ) of deep‐sea cold seeps. How the sulfur cycling is mediated by microbes near SMTZ has not been fully understood. In this study, we detected a shallow SMTZ in three of eight sediment cores sampled from two cold seep areas in the South China Sea. One hundred ten genomes representing sulfur‐oxidizing bacteria (SOB) and sulfur‐reducing bacteria (SRB) strains were identified from three SMTZ‐bearing cores. In the layers above SMTZ, SOB were mostly constituted by Campylobacterota, Gammaproteobacteria and Alphaproteobacteria that probably depended on nitrogen oxides and/or oxygen for oxidation of sulfide and thiosulfate in near‐surface sediment layers. In the layers below the SMTZ, the deltaproteobacterial SRB genomes and metatranscriptomes revealed CO 2 fixation by Wood–Ljungdahl pathway, sulfate reduction and nitrogen fixation for syntrophic or fermentative lifestyle. A total of 68% of the metagenome assembled genomes were not adjacent to known species in a phylogenomic tree, indicating a high diversity of bacteria involved in sulfur cycling. With the large number of genomes for SOB and SRB, our study uncovers the microbial populations that potentially mediate sulfur metabolism and associated carbon and nitrogen cycles, which sheds light on complex biogeochemical processes in deep‐sea environments.

Comparison on characterization and antioxidant activity of exopolysaccharides from two Porphyridium strains - Wei-Nan Wang; Yi Li; Ying Zhang; Wen-Zhou Xiang; Ai-Fen Li; Tao Li (Journal of Applied Phycology, 2021)

A cross-sectional study of chemotherapy-related AKI - Xin Kang; Xizi Zheng; Damin Xu; Tao Su; Ying Zhou; Jing Ji; Qi Yu; Yimin Cui; Li Yang (European Journal of Clinical Pharmacology, 2021)

Microplastics (MPs) Act as Sources and Vector of Pollutants‐Impact Hazards and Preventive Measures - Yingfei Sheng; Xueying Ye; Ying Zhou; Ruojia Li (Bulletin of Environmental Contamination and Toxicology, 2021)

Imaging and clinical features of cervical artery web: report of 41 cases and literature review - Minghui Wang; Ruizhi Zhou; Han Zhao; Lei Niu; Song Liu; Ying Li; Xuejun Liu (Acta Neurologica Belgica, 2021)

Association between large artery stenosis, cerebral small vessel disease and risk of ischemic stroke - Fei Han; Ding-Ding Zhang; Fei-Fei Zhai; Jun Xue; Jiang-Tao Zhang; Shuang Yan; Li-Xin Zhou; Jun Ni; Ming Yao; Meng Yang; Ming-Li Li; Zheng-Yu Jin; et al. (Science China Life Sciences, 2021)

Reduced Firing of Nucleus Accumbens Parvalbumin Interneurons Impairs Risk Avoidance in DISC1 Transgenic Mice - Xinyi Zhou; Bifeng Wu; Wenhao Liu; Qian Xiao; Wei He; Ying Zhou; Pengfei Wei; Xu Zhang; Yue Liu; Jie Wang; Jufang He; Zhigang Zhang; et al. (Neuroscience Bulletin, 2021)
A strong animal survival instinct is to approach objects and situations that are of benefit and to avoid risk. In humans, a large proportion of mental disorders are accompanied by impairments in risk avoidance. One of the most important genes involved in mental disorders is disrupted-in-schizophrenia-1 ( DISC1 ), and animal models in which this gene has some level of dysfunction show emotion-related impairments. However, it is not known whether DISC1 mouse models have an impairment in avoiding potential risks. In the present study, we used DISC1-N terminal truncation ( DISC1-N TM ) mice to investigate risk avoidance and found that these mice were impaired in risk avoidance on the elevated plus maze (EPM) and showed reduced social preference in a three-chamber social interaction test. Following EPM tests, c-Fos expression levels indicated that the nucleus accumbens (NAc) was associated with risk-avoidance behavior in DISC1-N TM mice. In addition, in vivo electrophysiological recordings following tamoxifen administration showed that the firing rates of fast-spiking neurons (FS) in the NAc were significantly lower in DISC1-N TM mice than in wild-type (WT) mice. In addition, in vitro patch clamp recording revealed that the frequency of action potentials stimulated by current injection was lower in parvalbumin (PV) neurons in the NAc of DISC1-N TM mice than in WT controls. The impairment of risk avoidance in DISC1-N TM mice was rescued using optogenetic tools that activated NAc PV neurons. Finally, inhibition of the activity of NAc PV neurons in PV-Cre mice mimicked the risk-avoidance impairment found in DISC1-N TM mice during tests on the elevated zero maze. Taken together, our findings confirm an impairment in risk avoidance in DISC1-N TM mice and suggest that reduced excitability of NAc PV neurons is responsible.

Protective Effects of Pidotimod Against Salmonella Infections - Yuanhao Zhou; Xiaolin Ye; Baikui Wang; Jiafu Ying; Zihan Zeng; Li Tang; Qi Wang; Peng Zou; Xiaoli Zhan; Luoqin Fu (International Journal of Peptide Research and Therapeutics, 2021)

Identification and colonization dynamics of an antagonistic endophytic bacterium 262XY2′ against Pseudomonas syringae causing tomato leaf spot disease - Chengde Yang; Zhonghong Feng; Ying Wang; Mengjun Jin; Tonghua Li; JingJiang Zhou (European Journal of Plant Pathology, 2021)

Exploring the dynamic mechanism of allosteric drug SHP099 inhibiting SHP2E69K - Shan Du; Xin-hua Lu; Wei-Ya Li; Li-Peng Li; Yang-Chun Ma; Liang Zhou; Jing-Wei Wu; Ying Ma; Run-Ling Wang (Molecular Diversity, 2021)

Diversity and function of rhizosphere microorganisms between wild and cultivated medicinal plant Glycyrrhiza uralensis Fisch under different soil conditions - Zhou-Yan Dong; Manik Prabhu Narsing Rao; Tian-Jiang Liao; Li Li; Yong-Hong Liu; Min Xiao; Osama Abdalla Abdelshafy Mohamad; Yue-Ying Tian; Wen-Jun Li (Archives of Microbiology, 2021)

Soil lead distribution characteristics and source identification in Hanyuan, upstream of Yangtze River, China - Xiaowen Liu; Dan Zhou; Xue Tang; Ying Li; Ying Yang; Yi Huang (Arabian Journal of Geosciences, 2021)

Biological characteristics and salt-tolerant plant growth-promoting effects of an ACC deaminase-producing Burkholderia pyrrocinia strain isolated from the tea rhizosphere - Lizhen Han; Hong Zhang; Yu Xu; Ying Li; Jing Zhou (Archives of Microbiology, 2021)

Genetic Architecture of Childhood Kidney and Urological Diseases in China - Ye Fang; Hua Shi; Tianchao Xiang; Jiaojiao Liu; Jialu Liu; Xiaoshan Tang; Xiaoyan Fang; Jing Chen; Yihui Zhai; Qian Shen; Guomin Li; Li Sun; et al. (Phenomics, 2021)
Kidney disease is manifested in a wide variety of phenotypes, many of which have an important hereditary component. To delineate the genotypic and phenotypic spectrum of pediatric nephropathy, a multicenter registration system is being implemented based on the Chinese Children Genetic Kidney Disease Database (CCGKDD). In this study, all the patients with kidney and urological diseases were recruited from 2014 to 2020. Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features. The genetic diagnosis was confirmed in 883 of 2256 (39.1%) patients from 23 provinces in China. Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome (SRNS, 23.5%), glomerulonephritis (GN, 32.2%), congenital anomalies of the kidney and urinary tract (CAKUT, 21.2%), cystic renal disease (3.9%), renal calcinosis/stone (3.6%), tubulopathy (9.7%), and chronic kidney disease of unknown etiology (CKDu, 5.8%). The pathogenic variants of 105 monogenetic disorders were identified. Ten distinct genomic disorders were identified as pathogenic copy number variants (CNVs) in 11 patients. The diagnostic yield differed by subgroups, and was highest in those with cystic renal disease (66.3%), followed by tubulopathy (58.4%), GN (57.7%), CKDu (43.5%), SRNS (29.2%), renal calcinosis /stone (29.3%) and CAKUT (8.6%). Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions. We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed. Our data demonstrate the utility of family-based exome sequencing, and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease.

N6-methyladenine DNA Demethylase ALKBH1 Regulates Mammalian Axon Regeneration - Qiao Li; Cheng Qian; Harry Feng; Tyger Lin; Qingsan Zhu; Ying Huang; Feng-Quan Zhou (Neuroscience Bulletin, 2021)

Endocrine Dysfunction Following Stroke - Fei Wang; Ming-ying Luo; Lei Zhou; Li Yang; Giuseppe Lanzino; Heng-Jui Chang; George C Wellman (Journal of Neuroimmune Pharmacology, 2021)

Embodied carbon emissions of aluminum-containing commodities in international trade: China’s perspective - Qiangfeng Li; Huabo Duan; Tianjiao Li; Yanjing Zhou; Ying Chen; Ruoyu Zhong (Climatic Change, 2021)

Altered structural and functional connectivity in CSF1R-related leukoencephalopathy - Fei-Xia Zhan; Ze-Yu Zhu; Qing Liu; Hai-Yan Zhou; Xing-Hua Luan; Xiao-Jun Huang; Xiao-Li Liu; Wo-Tu Tian; Shi-Ge Wang; Xiao-Xuan Song; Guang Chen; Ming-Liang Zhao; et al. (Brain Imaging and Behavior, 2021)

Design of supercontinuum laser hyperspectral light detection and ranging (LiDAR) (SCLaHS LiDAR) - Guoqing Zhou; Xiang Zhou; Youjian Song; Donghui Xie; Long Wang; Guangjian Yan; Minglie Hu; Bowen Liu; Weidong Shang; Chenghu Gong; Cheng Wang; Huaguo Huang; et al. (International Journal of Remote Sensing, 2021)

Sesquiterpenoids from Pilea cavaleriei - Yong Zhou; Ling-Yu Li; Xu Yin; Qing-Ying Zhang; Hong Liang; Peng-Fei Tu (Natural Product Research, 2021)

Mechanical Properties and Permeability Evolution of Red Sandstone Subjected to Hydro-mechanical Coupling: Experiment and Discrete Element Modelling - Qiang Wang; Xinli Hu; Wenbo Zheng; Lanxing Li; Chang Zhou; Chunye Ying; Chu Xu (Rock Mechanics and Rock Engineering, 2021)

A Xanthene Dye‐based Sensor for Viscosity and Cell Imaging - Bo Yu; Ying Zhou; Lihua Dou; Yunyun Li; Zhengwen Huang (Journal of Fluorescence, 2021)

Two novel flavonoids from the leaves of Rhododendron dauricum L. with their inhibition of TNF-α production in LPS-induced RAW 264.7 cells - Chao Ye; Mei Jin; Chunshi Jin; Rongshen Wang; Jiaming Wang; Ying Zhang; Sainan Li; Jinfeng Sun; Wei Zhou; Gao Li (Natural Product Research, 2021)

Associations between SNP83 of phosphodiesterase 4D gene and carotid atherosclerosis in a southern Chinese Han population: a case–control study - Liu-yu Liu; Dong-can Mo; Jian-li Li; Yi-ying Jiang; Guo-qiu Zhou; Dong-dong Jiang; Li-jie Chen; Xiao-ju Wu; Jiao-xing Li; Man Luo (Mammalian Genome, 2021)

Impact of solar ultraviolet radiation on daily outpatient visits of atopic dermatitis in Shanghai, China - Hui-jing Gu; Li Peng; Wen-cai Jiang; Yi-mei Tan; Guo-jiang Zhou; Hai-dong Kan; Ren-jie Chen; Ying Zou (Environmental Science and Pollution Research, 2021)

Clostridium butyricum Supernatant Regulates the Expression of RORγt in HCT-116 Cells by Inhibiting the TLR2/MyD88/NF-κB Signaling Pathway - Ying Xie; Linyan Zhou; Hui Li; Yan Li (Current Microbiology, 2021)

Mechanism of colluvial landslide induction by rainfall and slope construction: A case study - Zhou Zhou; Jun-hui Shen; Ying Li; Wei-feng Duan; Ri-chang Yang; Jun-cheng Shu; He-wei Li; Sheng-yu Tao; Sheng-zhe Zheng (Journal of Mountain Science, 2021)

Moderate oxidative stress promotes epithelial–mesenchymal transition in the lens epithelial cells via the TGF-β/Smad and Wnt/β-catenin pathways - Xi Chen; Hong Yan; Ying Chen; Guo Li; Yue Bin; Xiyuan Zhou (Molecular and Cellular Biochemistry, 2021)

Host genetics and gut microbiota cooperatively contribute to azoxymethane-induced acute toxicity in Collaborative Cross mice - Chenhan Zhong; Li He; Sun-Young Lee; Hang Chang; Yuqing Zhang; David W. Threadgill; Ying Yuan; Fuling Zhou; Susan E. Celniker; Yankai Xia; Antoine M. Snijders; Jian-Hua Mao (Archives of Toxicology, 2021)

Carnosic acid alleviates depression-like behaviors on chronic mild stressed mice via PPAR-γ-dependent regulation of ADPN/FGF9 pathway - Xiao-qing Wang; Ya-hui Tang; Gui-rong Zeng; Li-feng Wu; Ying-jun Zhou; Ze-neng Cheng; De-Jian Jiang (Psychopharmacology, 2021)

Transcriptome Analysis Identifies SenZfp536, a Sense LncRNA that Suppresses Self-renewal of Cortical Neural Progenitors - Kuan Tian; Andi Wang; Junbao Wang; Wei Li; Wenchen Shen; Yamu Li; Zhiyuan Luo; Ying Liu; Yan Zhou (Neuroscience Bulletin, 2021)

The role of MYB proto-oncogene like 2 in tamoxifen resistance in breast cancer - Xia Li; Xi Zhang; Cong-Cong Wu; Ping-Ping Li; Yi-Mou Fu; Li-Hua Xie; Shuang-Shuang Sun; Ying-Ying Zhou; Bao-Ling Zhu (Journal of Molecular Histology, 2021)

PapA , a peptidoglycan‐associated protein, interacts with OmpC and maintains cell envelope integrity - Yun‐Hao Wang; Hong‐He Chen; Zhou Huang; Xiao‐Jing Li; Nan Zhou; Chang Liu; Cheng‐Ying Jiang; De‐Feng Li; Shuang‐Jiang Liu (Environmental Microbiology, 2021)
Summary The bacterial cell envelope is critical to support and maintain cellular life. In Gram‐negative bacterial cells, the outer membrane and the peptidoglycan layer are two important parts of the cell envelope and they harbour abundant proteins. Here, we report the identification and characterization of a previously unknown p eptidoglycan‐ a ssociated p rotein, PapA, from the Gram‐negative Comamonas testosteroni . PapA bound peptidoglycan with its C‐terminal domain and interacted with the outer‐membrane porin OmpC. The PapA‐OmpC complex riveted the outer membrane and the peptidoglycan layer, and played a role in maintaining cell envelope integrity. When papA was disrupted, the mutant CNB‐1Δ papA apparently had an outer membrane partly separated from the peptidoglycan layer. Phenotypically, the mutant CNB‐1Δ papA lost chemotactic responses and had longer lag‐phase of growth, less flagellation and higher sensitivity to harsh environments. Totally, 1093 functionally unknown PapA homologues were identified from the public NR protein database and they were mainly distributed in Burkholderiales of Betaproteobacteria. Our finding provides a clue that the PapA homologous proteins might function as a rivet to maintain cell envelope integrity in those Gram‐negative bacteria.

Development and application of a comparative risk assessment method for ranking chemical hazards in food - Ying Li; Guoxin Liang; Lei Zhang; Zhaoping Liu; Dajin Yang; Jianwen Li; Guiju Sun; Pingping Zhou (Food Additives & Contaminants: Part A, 2021)

AMPK Ameliorates Tau Acetylation and Memory Impairment Through Sirt1 - Lin Wang; Fang-Xiao Shi; Na Li; Yun Cao; Ying Lei; Jian-Zhi Wang; Qing Tian; Xin-Wen Zhou (Molecular Neurobiology, 2020)

Transcriptome-wide identification and profiling of miRNAs in a stress-tolerant conifer Sabina chinensis - Xian-Ge Hu; Shan-Shan Zhou; Ying Yang; Hui Liu; Shrestha Anil; Qing Wang; Wei Zhao; Qiong Gao; Yousry A El-Kassaby; Tongli Wang; Yue Li; Jian-Feng Mao (Journal of Biosciences, 2020)

Effects of MC-LR on histological structure and cell apoptosis in the kidney of grass carp (Ctenopharyngodon idella) - Li He; Lin Liu; Changgao Lin; Jiming Ruan; Ximei Liang; Ying Zhou; Lili Wei (Fish Physiology and Biochemistry, 2020)

RamA, a transcriptional regulator conferring florfenicol resistance in Leclercia adecarboxylata R25 - Cong Cheng; Yuanyuan Ying; Danying Zhou; Licheng Zhu; Junwan Lu; Aifang Li; Qiyu Bao; Mei Zhu (Folia Microbiologica, 2020)
Due to the inappropriate use of florfenicol in agricultural practice, florfenicol resistance has become increasingly serious. In this work, we studied the novel florfenicol resistance mechanism of an animal-derived Leclercia adecarboxylata strain R25 with high-level florfenicol resistance. A random genomic DNA library was constructed to screen the novel florfenicol resistance gene. Gene cloning, gene knockout, and complementation combined with the minimum inhibitory concentration (MIC) detection were conducted to determine the function of the resistance-related gene. Sequencing and bioinformatics methods were applied to analyze the structure of the resistance gene-related sequences. Finally, we obtained a regulatory gene of an RND (resistance-nodulation-cell division) system, ramA , that confers resistance to florfenicol and other antibiotics. The ramA -deleted variant (LA-R25Δ ramA ) decreased the level of resistance against florfenicol and several other antibiotics, while a ramA -complemented strain (pUCP24-prom- ramA/ LA-R25Δ ramA ) restored the drug resistance. The whole-genome sequencing revealed that there were five RND efflux pump genes ( mdtABC , acrAB , acrD , acrEF , and acrAB -like) encoded over the chromosome, and ramA located upstream of the acrAB -like genes. The results of this work suggest that ramA confers resistance to florfenicol and other structurally unrelated antibiotics, presumably by regulating the RND efflux pump genes in L. adecarboxylata R25.

Prediction and Identification of Epitopes in the Emy162 Antigen of Echinococcus multilocularis - Ming-Quan Pang; Feng Tang; Hai-Jiu Wang; Ying Zhou; Li Ren; Run-Le Li; Hu Zhou; Chen-Fei Wan; Chuan-Chuan Liu; Cai-Rang Yangdan; Hai-Ning Fan (Acta Parasitologica, 2020)

Prevalence of Cryptosporidium Infection in the Global Population: A Systematic Review and Meta-analysis - Shurong Dong; Ya Yang; Yingjian Wang; Dongjian Yang; Yu Yang; Ying Shi; Chunlin Li; Linhan Li; Yue Chen; Qingwu Jiang; Yibiao Zhou (Acta Parasitologica, 2020)

Interleukin-1β in hypothalamic paraventricular nucleus mediates excitatory renal reflex - Fen Zheng; Chao Ye; Guo-Wei Wan; Bing Zhou; Ying Tong; Jian-Zhen Lei; Qi Chen; Yue-Hua Li; Yu-Ming Kang; Guo-Qing Zhu (Pflügers Archiv - European Journal of Physiology, 2020)

Bacillus tepidiphilus sp. nov., isolated from tepid spring - Manik Prabhu Narsing Rao; Zhou-Yan Dong; Yu Kan; Min Xiao; Ying Qian Kang; Wen-Jun Li (Archives of Microbiology, 2020)

Serological characteristics of COVID-19 patients - Mi Zhou; Jing Zhong; Lei Bi; Pengcheng Shang; Yan Xing; Bo Wang; Jianlan He; Ying Xu; Tao Luo; Maohua Ma; Qingfeng Li (Infectious Diseases, 2020)

Low Serum Uric Acid Levels Promote Hypertensive Intracerebral Hemorrhage by Disrupting the Smooth Muscle Cell-Elastin Contractile Unit and Upregulating the Erk1/2-MMP Axis - Ning Xiao; Tian-long Liu; Hao Li; Hao-chen Xu; Jing Ge; Hong-yan Wen; Cong-xia Bai; Li Song; Ying-ying Sun; Yin-hui Zhang; Ru-tai Hui; Wei-hua Song; et al. (Translational Stroke Research, 2020)

Serum LUCAT1 implicates the pathogenesis of muscle-invasive bladder cancer via targeting miR-199a-5p and miR-199b-5p - Yong Zhou; Xuejing Song; Xiameng Li; Huimin Li; Ying Peng (Journal of Molecular Histology, 2020)

Integrated biomarker parameters response to the toxic effects of high stocking density, CuSO4, and trichlorfon on fish and protective role mediated by Angelica sinensis extract - HuaTao Li; YuTing Ma; Ying Liu; Min Wu; Jiao Long; XiaoQin Jing; SiShun Zhou; Ping Yuan; Jun Jiang (Fish Physiology and Biochemistry, 2020)

Comparison of Four Amendments for Arsenic and Cadmium Combined Contaminated Soil - Ying Li; Jiaqi Wen; Pengfei Shen; Yu Zhou; Jianxiang Shen; Jinlin Jiang; Xiangji Kong; Xueyuan Gu (Bulletin of Environmental Contamination and Toxicology, 2020)

Spatiotemporal Characteristics of Rural Labor Migration in China: Evidence from the Migration Stability under New-type Urbanization - Wei Deng; Shaoyao Zhang; Peng Zhou; Li Peng; Ying Liu; Jiangjun Wan (Chinese Geographical Science, 2020)

Responses of Yield Fluctuation of Winter Oilseed Rape to Climate Anomalies in South China at Provincial Scale - Jin Huang; Limin Zhou; Fangmin Zhang; Ying Li (International Journal of Plant Production, 2020)

First case of Shewanella indica isolated from a Bryde’s whale (Balaenoptera edeni) stranded in the northern Beibu Gulf, China - Jia Li; Richard W. McLaughlin; Mo Chen; Ying Li Liu; Hia Xia Xie; Xiao Ling Wan; Jun Ying Zhou; Jin Song Zheng (Antonie van Leeuwenhoek, 2020)

A fundamental theorem for eco-environmental surface modelling and its applications - Tianxiang Yue; Na Zhao; Yu Liu; Yifu Wang; Bin Zhang; Zhengping Du; Zemeng Fan; Wenjiao Shi; Chuanfa Chen; Mingwei Zhao; Dunjiang Song; Shihai Wang; et al. (Science China Earth Sciences, 2020)

Impaired Parahippocampal Gyrus–Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer Disease - Lin Zhu; Zan Wang; Zhanhong Du; Xinyang Qi; Hao Shu; Duan Liu; Fan Su; Qing Ye; Xuemei Liu; Zheng Zhou; Yongqiang Tang; Ru Song; et al. (Neuroscience Bulletin, 2020)

Upregulation of AMPK Ameliorates Alzheimer’s Disease-Like Tau Pathology and Memory Impairment - Lin Wang; Na Li; Fang-Xiao Shi; Wei-Qi Xu; Yun Cao; Ying Lei; Jian-Zhi Wang; Qing Tian; Xin-Wen Zhou (Molecular Neurobiology, 2020)

Isolation of a Male-Specific Molecular Marker and Development of a Genetic Sex Identification Technique in Spotted Knifejaw (Oplegnathus punctatus) - Ming Li; Hao Xu; Wenteng Xu; Qian Zhou; Xiwen Xu; Ying Zhu; Weiwei Zheng; Wensheng Li; Zunfang Pang; Songlin Chen (Marine Biotechnology, 2020)

Occurrence and molecular characterization of apple scar skin viroid in Malus pumila ‘Saiwaihong’ (small apple tree) from North China - Shuai Li; Guang Xu Li; Ying Wei Khoo; Hua Yang; Guang Ren Zhang; Qi Dong Dai; Chang Yong Zhou; Shi Fang Li (Journal of Plant Pathology, 2020)

New insights into the resistance of four citrus genotypes to Xanthomonas citri subsp. citri - Peng Ying Mei; Yan Zhou; Zhong An Li; Chang Yong Zhou (Journal of Plant Pathology, 2020)

Pseudomonas Saliphila sp. nov., a Bacterium Isolated from Oil-Well Production Water in Qinghai Oilfield of China - Xiao-Juan Zhang; Hong-Can Liu; Yu-Guang Zhou; Xiao-Lei Wu; Yong Nie; Qi-Rui Li; Mei-Zhu Wang; Liang Zhao; Man Cai; Ying-Qian Kang (Current Microbiology, 2020)

Naphthalene exerts non-target effects on the abundance of active fungi by stimulating basidiomycete abundance - Li-ying Lan; Li Zhang; Ya Shen; Jian Zhang; Wan-qin Yang; Zhen-feng Xu; Yang Liu; Shu-qin He; Wei Zhou; Han Li; Li-xia Wang; Si-ning Liu; et al. (Journal of Mountain Science, 2020)

Lysinibacillus cavernae sp. nov., isolated from cave soil - Yu Kan; Xue-Ke Niu; Manik Prabhu Narsing Rao; Zhou-Yan Dong; Yuan-Guo Xie; Ying-Qian Kang; Wen-Jun Li (Archives of Microbiology, 2020)

Design and synthesis of novel 7-[( N -substituted-thioureidopiperazinyl)-methyl]-camptothecin derivatives as potential cytotoxic agents - Zi-Long Song; Guan-Zhou Yang; Jun-Cai Li; Ying-Qian Liu; Chen-Jie Yang; Masuo Goto; Zhi-Jun Zhang; Susan L. Morris-Natschke; Hua Liu; Kuo-Hsiung Lee (Natural Product Research, 2020)

A novel cross-sensor calibration method to generate a consistent night-time lights time series dataset - Ying Tu; Hanlin Zhou; Wei Lang; Tingting Chen; Xun Li; Bing Xu (International Journal of Remote Sensing, 2020)

A new triterpenoid glucoside from Leucas zeylanica - Guang-Ying Chen; Bin Zhang; Ting Zhao; Najat Nidhal; Wang Jia-Li; Xue-Ming Zhou; Dai Chun-Yan (Natural Product Research, 2020)

Correction to: EPAC Negatively Regulates Myelination via Controlling Proliferation of Oligodendrocyte Precursor Cells - Zheng-Zheng Gao; Ying-Cong Li; Chong-Yu Shao; Jian Xiao; Ying Shen; Liang Zhou (Neuroscience Bulletin, 2020)

EPAC Negatively Regulates Myelination via Controlling Proliferation of Oligodendrocyte Precursor Cells - Zhen-Zhen Gao; Ying-Cong Li; Chong-Yu Shao; Jian Xiao; Ying Shen; Liang Zhou (Neuroscience Bulletin, 2020)

Inhibition of glycolysis ameliorate arthritis in adjuvant arthritis rats by inhibiting synoviocyte activation through AMPK/NF-кB pathway - Ying Wang; Hao Xian; Jiajia Qi; Fang Wei; Xiu Cheng; Sha Li; Qing Wang; Zhaoyang Liu; Yun Yu; Jing Zhou; Xiaojin Sun; Hao Liu; et al. (Inflammation Research, 2020)

Science and Prediction of Heavy Rainfall over China: Research Progress since the Reform and Opening-Up of New China - Yali Luo; Jisong Sun; Ying Li; Rudi Xia; Yu Du; Shuai Yang; Yuanchun Zhang; Jing Chen; Kan Dai; Xueshun Shen; Haoming Chen; Feifan Zhou; et al. (Journal of Meteorological Research, 2020)

Rock burst risk assessment in deep-buried underground caverns: a novel analysis method - Zhiqiang Li; Yiguo Xue; Shucai Li; Daohong Qiu; Lewen Zhang; Ying Zhao; Binghua Zhou (Arabian Journal of Geosciences, 2020)

Elastic reverse-time migration in irregular tunnel environment based on polar coordinates - Ying-Ming Qu; Chang Zhou; Qurmet Worral; Zhen-Chun Li; Chang-Bo Wang; Jun-Zhi Sun (Applied Geophysics, 2020)

Traits mediate drought effects on wood carbon fluxes - Zhenhong Hu; Han Y. H. Chen; Chao Yue; Xiao Ying Gong; Junjiong Shao; Guiyao Zhou; Jiawei Wang; Minhuang Wang; Jianyang Xia; Yongtao Li; Xuhui Zhou; Sean T. Michaletz (Global Change Biology, 2020)
CO 2 fluxes from wood decomposition represent an important source of carbon from forest ecosystems to the atmosphere, which are determined by both wood traits and climate influencing the metabolic rates of decomposers. Previous studies have quantified the effects of moisture and temperature on wood decomposition, but these effects were not separated from the potential influence of wood traits. Indeed, it is not well understood how traits and climate interact to influence wood CO 2 fluxes. Here, we examined the responses of CO 2 fluxes from dead wood with different traits (angiosperm and gymnosperm) to 0%, 35%, and 70% rainfall reduction across seasonal temperature gradients. Our results showed that drought significantly decreased wood CO 2 fluxes, but its effects varied with both taxonomical group and drought intensity. Drought‐induced reduction in wood CO 2 fluxes was larger in angiosperms than gymnosperms for the 35% rainfall reduction treatment, but there was no significant difference between these groups for the 70% reduction treatment. This is because wood nitrogen density and carbon quality were significantly higher in angiosperms than gymnosperms, yielding a higher moisture sensitivity of wood decomposition. These findings were demonstrated by a significant positive interaction effect between wood nitrogen and moisture on CO 2 fluxes in a structural equation model. Additionally, we ascertained that a constant temperature sensitivity of CO 2 fluxes was independent of wood traits and consistent with previous estimates for extracellular enzyme kinetics. Our results highlight the key role of wood traits in regulating drought responses of wood carbon fluxes. Given that both climate and forest management might extensively modify taxonomic compositions in the future, it is critical for carbon cycle models to account for such interactions between wood traits and climate in driving dynamics of wood decomposition.

Colletotrichum fructicola STE50 is required for vegetative growth, asexual reproduction, appressorium formation, pathogenicity and the response to external stress - Yan-ying Chen; Jun-ang Liu; Shi-qiang Jiang; He Li; Guo-ying Zhou (Journal of Plant Pathology, 2020)

Integrated fate assessment of aromatic amines in aerobic sewage treatment plants - Lin Jun Zhou; Zhi Yi Rong; Wen Gu; De Ling Fan; Ji Ning Liu; Li Li Shi; Yan Hua Xu; Zhi Ying Liu (Environmental Monitoring and Assessment, 2020)
The fate and exposure of chemicals in sewage treatment plants (STPs) are major considerations in risk assessment and environmental regulation. The biodegradability and removal of seven aromatic amines were systematically evaluated using a three-tiered integrated method: a standard ready biodegradability test, an aerobic sewage treatment simulation method, and model prediction. In tier 1, the seven aromatic amines were not readily biodegraded after 28 days. In adapted aerobic active sludge, 4-isopropyl aniline, 2,4-diaminotoluene, and 4-nitroaniline among them exhibited the degradation half-life time less than 20 h, the other four aromatic amines exhibited persistent with degradation half-life of > 60 h. In tier 2 of the aerobic sewage treatment simulation testing, 2,4-diaminotoluene, 4-nitroaniline, and 4-isopropylaniline demonstrated moderately to high overall removal. Hydraulic retention time (HRT) affects the removal with the optimum HRT was determined to be 12 h to 24. 2,6-Dimethyl aniline, 2-chloro-4-nitroaniline, 2,6-diethylaniline, and 3,4-dichloroaniline were not removed during the test, indicting these four aromatic amines will enter surface water and hence pose a potential risk to aquatic ecology. Considering the lack of an STP model in China for regulation purposes, in tier 3, we developed a Chinese STP (aerobic) (abbreviated as C-STP(O)) model that reflects a universal scenario for China to predict the fate. The predicted degradation, volatilization, and absorption showed a close relationship to the physicochemical properties of the chemicals, and had same tendency with tier 2 simulation test. The prediction showed that biodegradation rather than absorption or volatilization was the main removal process of aromatic amines in aerobic STP. With the combination of modified kinetics test with C-STP (O) model, the chemical fate can be more accurately predicted than using only the readily biodegradation result.

Phylogenetic patterns of shrub communities along the longitudinal and latitudinal gradients on the northeastern Qinghai–Tibetan Plateau - Yuan-ming Xiao; Lu-cun Yang; Xiu-qing Nie; Chang-bin Li; Feng Xiong; Guo-ying Zhou (Journal of Mountain Science, 2020)

Perfusion Changes of Unexplained Early Neurological Deterioration After Reperfusion Therapy - Jingjing Fu; Ying Zhou; Qingqing Li; Genlong Zhong; Sheng Zhang; Ruiting Zhang; Chang Liu; Minming Zhang; Min Lou (Translational Stroke Research, 2020)

The protective effects of Mogroside V and its metabolite 11-oxo-mogrol of intestinal microbiota against MK801-induced neuronal damages - Peijun Ju; Wenhua Ding; Jianhua Chen; Ying Cheng; Beibei Yang; Lanting Huang; Qiong Zhou; Cuizhen Zhu; Xiaobo Li; Mengyue Wang; Jinghong Chen (Psychopharmacology, 2020)

Optimization of the protoplast transient expression system for gene functional studies in strawberry (Fragaria vesca) - Yi-Jie Gou; Yu-Lian Li; Pin-Pin Bi; Dan-Juan Wang; Yang-Yang Ma; Yang Hu; Hou-Cheng Zhou; Ying-Qiang Wen; Jia-Yue Feng (Plant Cell, Tissue and Organ Culture (PCTOC), 2020)

The acute effects of ultraviolet radiation exposure on solar dermatitis in Shanghai, China - Guojiang Zhou; Li Peng; Wei Gao; Ying Zou; Yimei Tan; Yangfeng Ding; Shanqun Li; Hong Sun; Renjie Chen (International Journal of Biometeorology, 2020)

Polymorphisms in arsenic (+ 3 oxidation state) methyltransferase (AS3MT) predict the occurrence of hyperleukocytosis and arsenic metabolism in APL patients treated with As2O3 - Wen-Sheng Liu; Xin-Yu Wang; Jing Lu; Ying-Mei Zhang; Xiang-Mei Ye; Jin-Mei Li; Qi-Lei Zhao; Zhi-Qiang Wu; Jin Zhou; Xin Hai (Archives of Toxicology, 2020)

GPR based RTM imaging technology for estimating rhizome diameters and application in the western China mining area - Fan Cui; Shuai Li; Jiong-Xuan Yuan; Jie-Bin Bai; Yu-Xuan Zhao; Ying-Ging Zhou (Applied Geophysics, 2020)

Isolation of a new natural kingiside aglucone derivative and other anti-inflammatory constituents from Syringa reticulata - Chunshi Jin; Mei Jin; Ren Li; Shengbao Diao; Jinfeng Sun; Ying Jie Ma; Wei Zhou; Gao Li (Natural Product Research, 2020)

Detection of Small Ship Objects Using Anchor Boxes Cluster and Feature Pyramid Network Model for SAR Imagery - Peng Chen; Ying Li; Hui Zhou; Bingxin Liu; Peng Liu (Journal of Marine Science and Engineering, 2020)
The synthetic aperture radar (SAR) has a special ability to detect objects in any climate and weather conditions. Consequently, SAR images are widely used in maritime transportation safety and fishery law enforcement for maritime object detection. Currently, deep-learning models are being extensively used for the detection of objects from images. Among them, the feature pyramid network (FPN) uses pyramids for representing semantic information regardless of the scale and has an improved accuracy of object detection. It is also suitable for the detection of multiple small ship objects in SAR images. This study aims to resolve the problems associated with small-object and multi-object ship detection in complex scenarios e.g., when a ship nears the port, by proposing a detection method based on an optimized FPN model. The feature pyramid model is first embedded in a traditional region proposal network (RPN) and mapped into a new feature space for object identification. Subsequently, the k-means clustering algorithm based on the shape similar distance (SSD) measure is used to optimize the FPN. Initial anchor boxes and tests are created using the SAR ship dataset. Experimental results show that the proposed algorithm for object detection shows an accuracy of 98.62%. Compared with Yolo, the RPN based on VGG/ResNet, FPN based on VGG/ResNet, and other models in complex scenarios, the proposed model shows a higher accuracy rate and better overall performance.

Enhanced stability of a rumen-derived xylanase using SpyTag/SpyCatcher cyclization - Ye-Bo Zhou; Jia-Wen Cao; Xiao-Bao Sun; Huan Wang; De-Ying Gao; Yang-Nan Li; Kai-Yue Wu; Jia-Kun Wang; Guo-Ying Qian; Qian Wang (World Journal of Microbiology and Biotechnology, 2020)

Betulinic acid attenuates lipopolysaccharide-induced vascular hyporeactivity in the rat aorta by modulating Nrf2 antioxidative function - Yao-Yao Bai; Dong Yan; Hui-Ying Zhou; Wei-Xin Li; Yang-Yun Lou; Xin-Ru Zhou; Ling-Bo Qian; Chi Xiao (Inflammopharmacology, 2020)

Development of Climate and Earth System Models in China: Past Achievements and New CMIP6 Results - Tianjun Zhou; Ziming Chen; Liwei Zou; Xiaolong Chen; Yongqiang Yu; Bin Wang; Qing Bao; Ying Bao; Jian Cao; Bian He; Shuai Hu; Lijuan Li; et al. (Journal of Meteorological Research, 2020)

Controlled Release of Spirotetramat Using Starch–Chitosan–Alginate-Encapsulation - Yan-Li Xie; Wayne Jiang; Fen Li; Yu Zhang; Xiao-Yu Liang; Meng Wang; Xueqing Zhou; Shao-Ying Wu; Cheng-Hui Zhang (Bulletin of Environmental Contamination and Toxicology, 2020)

Water and heat availability are drivers of the aboveground plant carbon accumulation rate in alpine grasslands on the Tibetan Plateau - Jian Sun; Tian‐Cai Zhou; Miao Liu; You‐Chao Chen; Guo‐Hua Liu; Ming Xu; Pei‐Li Shi; Fei Peng; Atsushi Tsunekawa; Yu Liu; Xiao‐Dan Wang; Shi‐Kui Dong; et al. (Global Ecology and Biogeography, 2020)
Aim Climate change is expected to have important effects on plant phenology and carbon storage, with further shifts predicted in the future. Therefore, we proposed the community carbon accumulation rate (CAR) from the start of the growing season (SOS) to the peak of the growing season (POS) to fill the gap that the dynamic interactions between plant phenology and plant carbon research. Location Tibetan Plateau. Major taxa Alpine grassland plants. Time period 2015. Methods We conducted a transect survey across grasslands to measure community aboveground net primary production and carbon concentration. Additionally, phenology indicator data (SOS and POS) were extracted from the Global Inventory Modeling and Mapping Studies (GIMMS) normalized difference vegetation index version 3 database. Next, we used ‘ changepoint ’ analysis to detect the patterns of CARs, and performed linear regression and one‐way ANOVA to explore the variability of CARs in response to the environmental factors. Ultimately, the total effects of environmental factors on CARs were illustrated by a structural equation model. Results Our results indicated that three CAR patterns were detected, which are low‐CAR (0.15 g/m 2 /day), medium‐CAR (0.31 g/m 2 /day) and high‐CAR (0.84 g/m 2 /day) patterns. We found that the availabilities of water and heat mediated CARs by regulating soil nutrition variability, and that drought climate and insufficient soil resources co‐constrained the community CAR at long time‐scales. In contrast, high CAR could be explained by more water and heat availability via either direct or indirect effects on soil moisture and soil nutrients. Main conclusions Our findings highlight that water and heat availability are critical driving factors in ecological carbon accumulation processes undergoing climate change. Meanwhile, the vegetative phenology also has important effect on carbon accumulation. Consequently, we propose incorporating the dynamic interactions between plant phenology and plant carbon into the ecological carbon cycle model to improve our understanding of resource utilization and survival strategies of plants under environmental change.

Evidences of aromatic degradation dominantly via the phenylacetic acid pathway in marine benthic Thermoprofundales - Wei‐Wei Liu; Jie Pan; Xiaoyuan Feng; Meng Li; Ying Xu; Fengping Wang; Ning‐Yi Zhou (Environmental Microbiology, 2020)
Summary Thermoprofundales (Marine Benthic Group D archaea, MBG‐D) is a newly proposed archaeal order and widely distributed in global marine sediment, and the members in the order may play a vital role in carbon cycling. However, the lack of pure cultures of these oeganisms has hampered the recognition of their catabolic roles. Here, by constructing high‐quality metagenome‐assembled genomes (MAGs) of two new subgroups of Thermoprofundales from hydrothermal sediment and predicting their catabolic pathways, we here provide genomic evidences that Thermoprofundales are capable of degrading aromatics via the phenylacetic acid (PAA) pathway. Then, the gene sequences of phenylacetyl‐CoA ligase (PCL), a key enzyme for the PAA pathway, were searched in reference genomes. The widespread distribution of PCL genes among 14.9% of archaea and 75.9% of Thermoprofundales further supports the importance of the PAA pathway in archaea, particularly in Thermoprofundales where no ring‐cleavage dioxygenases were found. Two PCLs from Thermoprofundales MAGs, PCL M8‐3 and PCL M10‐15 , were able to convert PAA to phenylacetyl‐CoA (PA‐CoA) in vitro , demonstrating the involvement of Thermoprofundales in aromatics degradation through PAA via CoA activation. Their acid tolerance (pH 5–7), high‐optimum temperatures (60°C and 80°C), thermostability (stable at 60°C and 50°C for 48 h) and broad substrate spectra imply that Thermoprofundales are capable of transforming aromatics under extreme conditions. Together with the evidence of in situ transcriptional activities for most genes related to the aromatics pathway in Thermoprofundales, these genomic, and biochemical evidences highlight the essential role of this ubiquitous and abundant archaeal order in the carbon cycle of marine sediments.

All-trans-retinoic acid generation is an antidotal clearance pathway for all-trans-retinal in the retina - Qing-qing Xia; Ling-min Zhang; Ying-ying Zhou; Ya-lin Wu; Jie Li (Journal of Zhejiang University-SCIENCE B, 2019)

Spatial–Spectral Jointed Stacked Auto-Encoder-Based Deep Learning for Oil Slick Extraction from Hyperspectral Images - Bingxin Liu; Qiang Zhang; Ying LI; Wen Chang; Manrui Zhou (Journal of the Indian Society of Remote Sensing, 2019)

Multi‐model analysis of climate impacts on plant photosynthesis in China during 2000–2015 - Hao Yan; Shao‐Qiang Wang; Jun‐Bang Wang; Yun Cao; Ling‐Ling Xu; Men‐Xin Wu; Lu Cheng; Liu‐Xi Mao; Feng‐Hua Zhao; Xian‐Zhou Zhang; Yun‐Fen Liu; Yan‐Fen Wang; et al. (International Journal of Climatology, 2019)
Differences, arising from differences in gross primary production (GPP) model structures and driving forces, have fuelled arguments concerning interannual changes of GPP in China since 2000. To better investigate the interannual variability of GPP and its covariance with climate factors in China, this study adopted a multi‐model analysis based on three GPP models (i.e., Terrestrial Ecosystem Carbon flux model [TEC], Breathing Earth System Simulator model [BESS], and MOD17 GPP model). The results show that annual GPP in China increased by 0.021–0.057 Pg C year −1 from 2000 to 2015 attributable to atmospheric‐CO 2 fertilization effects and favourable climate change, that is, increasing precipitation ( P r ) and temperature ( T a ). However, northern China and southern China had a large difference in the amplitude of these GPP changes; annual GPP increased by 0.017–0.039 Pg C year −1 in northern China but only 0.001–0.018 Pg C year −1 in southern China. Northern China and southern China occupy contrasting climate zones and this contrast produced different interannual variability of GPP through different mechanisms. Northern China has a dry climate with GPP changes sensitive to P r . As a result, more P r along with higher T a in northern China produced the strong uptrend of GPP from 2000 to 2015. In contrast, southern China has a wet climate with its GPP sensitive to solar radiation and T a . For the interval of 2000–2015, decreasing radiation plus drought exerted a negative influence on GPP in southern China. This study highlights the diverse mechanisms in which climate change affects GPP in dry and wet climate zones. A robust multi‐model analysis is preferred to reduce uncertainties arising from a single GPP model and its driving data.

Asymmetric responses of plant community structure and composition to precipitation variabilities in a semi-arid steppe - Mingxing Zhong; Jian Song; Zhenxing Zhou; Jingyi Ru; Mengmei Zheng; Ying Li; Dafeng Hui; Shiqiang Wan (Oecologia, 2019)

Comparative genomic analysis of subspecies of Pantoea stewartii reveals distinct variations - Peng Li; Ying Zhang; Yuqingqing Sun; Xingxing Wu; Zhiyuan Wang; Jianuan Zhou; Xiaofan Zhou (Journal of Plant Pathology, 2019)

Functional characterization of three MATE genes in relation to aluminum-induced citrate efflux from soybean root - Ying Zhou; Zhengbiao Wang; Li Gong; Anle Chen; Ning Liu; Sha Li; Haoran Sun; Zhenming Yang; Jiangfeng You (Plant and Soil, 2019)

Association of the Polygenic Risk Score with the Incidence Risk of Parkinson’s Disease and Cerebrospinal Fluid α-Synuclein in a Chinese Cohort - Wei-Wei Li; Dong-Yu Fan; Ying-Ying Shen; Fa-Ying Zhou; Yang Chen; Ye-Ran Wang; Heng Yang; Jing Mei; Ling Li; Zhi-Qiang Xu; Yan-Jiang Wang (Neurotoxicity Research, 2019)

Genetic Association Between NGFR, ADAM17 Gene Polymorphism, and Parkinson’s Disease in the Chinese Han Population - Wei-Wei Li; Ying-Ying Shen; Dong-Wan Chen; Hui-Yun Li; Qian-Qian Shi; Jing Mei; Heng Yang; Fa-Ying Zhou; An-Yu Shi; Tao Zhang; Xiu-Qing Yao; Zhi-Qiang Xu; et al. (Neurotoxicity Research, 2019)

Open shear fractures at depth in anticlines: insights from the Kuqa foreland thrust belt, Tarim Basin - Zhao Wang; Xiuxiang Lv; Ying Li; Wenwen Qian; Shanshan Hu; Xiaoxiao Zhou; Han Quan (International Journal of Earth Sciences, 2019)

Genome-wide association analysis of salt tolerance QTLs with SNP markers in maize (Zea mays L.) - Yonghong Xie; Yan Feng; Qi Chen; Feike Zhao; Shuijuan Zhou; Ying Ding; Xianliang Song; Ping Li; Baohua Wang (Genes & Genomics, 2019)

LlDREB1G, a novel DREB subfamily gene from Lilium longiflorum, can enhance transgenic Arabidopsis tolerance to multiple abiotic stresses - Baojun Liu; Ying Zhou; Wu Lan; Qin Zhou; Fei Li; Feng Chen; Manzhu Bao; Guofeng Liu (Plant Cell, Tissue and Organ Culture (PCTOC), 2019)

Monitoring the regional deformation of loess landslides on the Heifangtai terrace using the Sentinel-1 time series interferometry technique - Qingkai Meng; Qiang Xu; Baocun Wang; Weile Li; Ying Peng; Dalei Peng; Xing Qi; Dongdong Zhou (Natural Hazards, 2019)

A reverse-transcription loop-mediated isothermal amplification (RT-LAMP) assay for detecting the pathogen of maize rough dwarf disease in China - Linlin Du; Wenjuan Shi; Xuejuan Li; Ying Lan; Feng Sun; Yongjian Fan; Tong Zhou; Yijun Zhou (Australasian Plant Pathology, 2019)

Multiparameter least-squares reverse time migration for acoustic—elastic coupling media based on ocean bottom cable data - Ying-Ming Qu; Chong-Peng Huang; Chang Liu; Chang Zhou; Zhen-Chun Li; Qurmet Worral (Applied Geophysics, 2019)

Neurotrophin Receptor p75 mRNA Level in Peripheral Blood Cells of Patients with Alzheimer’s Disease - Yali Xu; Wei-Wei Li; Jun Wang; Chi Zhu; Ying-Ying Shen; An-Yu Shi; Gui-Hua Zeng; Zhi-Qiang Xu; Xin-Fu Zhou; Yan-Jiang Wang (Neurotoxicity Research, 2019)

Classification model for surrounding rock based on the PCA-ideal point method: an engineering application - Yiguo Xue; Zhiqiang Li; Daohong Qiu; Lewen Zhang; Ying Zhao; Xueliang Zhang; Binghua Zhou (Bulletin of Engineering Geology and the Environment, 2019)

The role of MAPK signaling pathway in formation of EMT in oral squamous carcinoma cells induced by TNF-α - Xiao-Wei Zhao; Jing-Ping Zhou; Yu-Lan Bi; Jia-Ying Wang; Rui Yu; Chao Deng; Wei-Kang Wang; Xian-Zhen Li; Rui Huang; Jili Zhang; De-Tao Tao (Molecular Biology Reports, 2019)

PM2.5 affects establishment of immune tolerance in newborn mice by reducing PD-L1 expression - Li Yan; Caihui Gong; Linyan Ying; Wenlong Fu; Sha Liu; Jihong Dai; Zhou Fu (Journal of Biosciences, 2019)

An Outbreak of Gastroenteritis Associated with GII.17 Norovirus-Contaminated Secondary Water Supply System in Wuhan, China, 2017 - Xuan Zhou; De-Guang Kong; Jing Li; Bei-Bei Pang; Ying Zhao; Jun-Bo Zhou; Ting Zhang; Jun-Qiang Xu; Nobumichi Kobayashi; Yuan-Hong Wang (Food and Environmental Virology, 2019)

Dimethylaminomicheliolide ameliorates peritoneal fibrosis through the activation of autophagy - Shuting Li; Fenfen Peng; Wangqiu Gong; Jiayu Wu; Yuxian Wang; Zhaozhong Xu; Wenting Liu; Hongyu Li; Bohui Yin; Ying Zhang; Sijia Chen; Congwei Luo; et al. (Journal of Molecular Medicine, 2019)

Effect of iron plaque and selenium on mercury uptake and translocation in rice seedlings grown in solution culture - Xin Bin Zhou; Ying Ying Li (Environmental Science and Pollution Research, 2019)

Effects of phosphorus on absorption and transport of selenium in rice seedlings - Ying Ying Li; Shu Hui Yu; Xin Bin Zhou (Environmental Science and Pollution Research, 2019)

Serum and Seminal Plasma Element Concentrations in Relation to Semen Quality in Duroc Boars - Ying-hui Wu; Wen Lai; Zi-hui Liu; Hong-kui Wei; Yuan-fei Zhou; Jia-jian Tan; Hai-qing Sun; Sheng-qing Li; Jian Peng (Biological Trace Element Research, 2019)

Intrathecal Injection of Allogenic Bone Marrow-Derived Mesenchymal Stromal Cells in Treatment of Patients with Severe Ischemic Stroke: Study Protocol for a Randomized Controlled Observer-Blinded Trial - Lingna Deng; Qingxia Peng; Hongxuan Wang; Jingrui Pan; Ying Zhou; Kuang Pan; Jinteng Li; Yanfeng Wu; Yidong Wang (Translational Stroke Research, 2019)

Field-aged biochar reduces the greenhouse gas balance in a degraded vegetable field treated by reductive soil disinfestation - Bo Li; Jun Zhou; Ying Lu; Zhengqin Xiong (Environmental Science and Pollution Research, 2019)

Enhanced water solubility, antioxidant activity, and oral absorption of hesperetin by D-α-tocopheryl polyethylene glycol 1000 succinate and phosphatidylcholine - Su-Fang Gu; Li-Ying Wang; Ying-Jie Tian; Zhu-Xian Zhou; Jian-Bin Tang; Xiang-Rui Liu; Hai-Ping Jiang; You-Qing Shen (Journal of Zhejiang University-SCIENCE B, 2019)

Simultaneous quantitative analysis of 11 flavonoid derivatives with a single marker in persimmon leaf extraction and evaluation of their myocardium protection activity - Zhi Zhou; Nan Li; Hai-Feng Zhang; Qing-Qing Wang; Qing Yu; Fang Wang; Ying-Hui Dai; Dong Wang; Dong-Chun Liu (Journal of Natural Medicines, 2019)

Impaired Hypothalamic Regulation of Sympathetic Outflow in Primary Hypertension - Jing-Jing Zhou; Hui-Jie Ma; Jian-Ying Shao; Hui-Lin Pan; De-Pei Li (Neuroscience Bulletin, 2019)

Synthesis and biological evaluation of novel SIPI-7623 derivatives as farnesoid X receptor (FXR) antagonists - Si-Yun Nian; Guo-Ping Wang; Zheng-Li Jiang; Ying Xiao; Mo-Han Huang; Yi-Huan Zhou; Xiang-Duan Tan (Molecular Diversity, 2019)

Mesenchymal stem cells attenuate sepsis-induced liver injury via inhibiting M1 polarization of Kupffer cells - Xujing Liang; Taoyuan Li; Qiuchan Zhou; Sainan Pi; Yadan Li; Xiaojia Chen; Zeping Weng; Hongmei Li; Ying Zhao; Huadong Wang; Youpeng Chen (Molecular and Cellular Biochemistry, 2019)

Hepatoprotective effect of gastrodin against alcohol-induced liver injury in mice - Xin-Xin Li; Zhi-Hui Jiang; Bo Zhou; Chen Chen; Xiao-Ying Zhang (Journal of Physiology and Biochemistry, 2019)

Prediction of cadmium concentration in brown rice before harvest by hyperspectral remote sensing - Weihong Zhou; Jingjing Zhang; Mengmeng Zou; Xiaoqing Liu; Xiaolong Du; Qian Wang; Yangyang Liu; Ying Liu; Jianlong Li (Environmental Science and Pollution Research, 2019)

The Influence of Cellulosic Polymer’s Variables on Dissolution/Solubility of Amorphous Felodipine and Crystallization Inhibition from a Supersaturated State - Nian-Qiu Shi; Ying Jin; Yong Zhang; Xiao-Xia Che; Xiao Xiao; Gui-Hua Cui; Yu-Zhou Chen; Bo Feng; Zheng-Qiang Li; Xian-Rong Qi (AAPS PharmSciTech, 2019)

Effects of topographic factors and aboveground vegetation carbon stocks on soil organic carbon in Moso bamboo forests - Huiyun Fang; Biyong Ji; Xu Deng; Jiayang Ying; Guomo Zhou; Yongjun Shi; Lin Xu; Jixing Tao; Yufeng Zhou; Chong Li; Hao Zheng (Plant and Soil, 2018)

Aquimarina sediminis sp. nov., isolated from coastal sediment - Nan-Nan Wang; Liu-Yan Zhou; Ying-Xiu Li; Zong-Jun Du (Antonie van Leeuwenhoek, 2018)

Dendrocoumarin: a new benzocoumarin derivative from the stem of Dendrobium nobile - Xue-Ming Zhou; Bin Zhang; Guang-Ying Chen; Chang-Ri Han; Kun-Chi Jiang; Ming-Yue Luo; Bo-Zheng Meng; Wen-Xin Li; Shi-Dai Lin (Natural Product Research, 2018)

Dual-functionality of RASSF1A overexpression in A375 cells is mediated by activation of IL-6/STAT3 regulatory loop - Mei Yi; Wei Wang; Shengnan Chen; Ya Peng; Junjun Li; Jing Cai; Ying Zhou; Qian Peng; Yuanyuan Ban; Zhaoyang Zeng; Xiaoling Li; Wei Xiong; et al. (Molecular Biology Reports, 2018)

p38 Inhibitor Protects Mitochondrial Dysfunction by Induction of DJ-1 Mitochondrial Translocation After Subarachnoid Hemorrhage - Liyong Huang; Yaqing Hou; Lei Wang; Xiahui Xu; Qingkai Guan; Xiangsheng Li; Ying Chen; Wenke Zhou (Journal of Molecular Neuroscience, 2018)

Expression of ASIC3 in the Trigeminal Nucleus Caudalis Plays a Role in a Rat Model of Recurrent Migraine - Sha Wang; Bai-Xue Wu; Chao-Yang Liu; Guang-Cheng Qin; Wen-Hui Yan; Ji-Ying Zhou; Li-Xue Chen (Journal of Molecular Neuroscience, 2018)