Using short-interval landslide inventories to build short-term and overall spatial prediction models for earthquake-triggered landslides based on machine learning for the 2018 Lombok earthquake sequence - Changhu Xue; Kejie Chen; Hui Tang; Chaoqi Lin; Wenfeng Cui (Natural Hazards, 2022)

Transcranial Direct-Current Stimulation Regulates MCT1-PPA-PTEN-LONP1 Signaling to Confer Neuroprotection After Rat Cerebral Ischemia–Reperfusion Injury - Xiangyi Kong; Wenjie Hu; Yu Cui; Jingchen Gao; Xujin Yao; Jinyang Ren; Tao Lin; Jiangdong Sun; Yunyi Gao; Xiaohua Li; Hui Wang; Huanting Li; et al. (Molecular Neurobiology, 2022)
Propionic acid (PPA) is a critical metabolite involved in microbial fermentation, which functions to reduce fat production, inhibit inflammation, and reduce serum cholesterol levels. The role of PPA in the context of cerebral ischemia–reperfusion (I/R) injury has yet to be clarified. Increasing evidence indicate that transcranial direct-current stimulation (tDCS) is a safe approach that confers neuroprotection in cerebral ischemia injury. Here, we show that the levels of PPA were reduced in the ischemic brain following a rat cerebral I/R injury and in the cultured rat cortical neurons after oxygen–glucose deprivation (OGD), an in vitro model of ischemic injury. We found that the decreased levels of transporter protein monocarboxylate transporter-1 (MCT1) were responsible for the OGD-induced reduction of PPA. Supplementing PPA reduced ischemia-induced neuronal death after I/R. Moreover, our results revealed that the neuroprotective effect of PPA is mediated through downregulation of phosphatase PTEN and subsequent upregulation of Lon protease 1 (LONP1). We demonstrated that direct-current stimulation (DCS) increased MCT1 expression and PPA level in OGD-insulted neurons, while tDCS decreased the brain infarct volume in the MCAO rats via increasing the levels of MCT1 expression and PPA. This study supports a potential application of tDCS in ischemic stroke.

Transplantation of Nasal Olfactory Mucosa Mesenchymal Stem Cells Benefits Alzheimer’s Disease - Chun-Gu Hong; Meng-Lu Chen; Ran Duan; Xin Wang; Zhi-Lin Pang; Li-Te Ge; Ming Lu; Hui Xie; Zheng-Zhao Liu (Molecular Neurobiology, 2022)

Uncovering expression and functional analysis of newly discovered high-affinity K+ transporter family members from sugarcane - Hai-bin Luo; Cheng-mei Huang; Yuan-wen Wei; Hui-ming Zhu; Hui-qing Cao; Sheng-li Jiang; Zhi-nian Deng; Kai-chao Wu; Lin Xu (Journal of Plant Biochemistry and Biotechnology, 2022)

Breast cancer incidence in a national cohort of female workers exposed to special health hazards in Taiwan: a retrospective case-cohort study of ~ 300,000 occupational records spanning 20 years - Yun-Shiuan Chuang; Chun-Ying Lee; Pei-Chen Lin; Chih-Hong Pan; Hui-Min Hsieh; Chia-Fang Wu; Ming-Tsang Wu (International Archives of Occupational and Environmental Health, 2022)

An association study on the risk, glucocorticoids effectiveness, and prognosis of systemic lupus erythematosus: insight from mitochondrial DNA copy number - Zhen Li; Qi-Qun Zong; Chun-Xia Zhai; Guang-Hui Yu; Wan-Qin Hu; Yu-Hua Wang; Lin-Lin Wang; Zi-Ye Yan; Ting-Yu Zhang; Ying Teng; Shuang Liu; Jing Cai; et al. (Immunologic Research, 2022)

Biophysical controls on spatial and summer/winter distributions of total and chromophoric dissolved organic matter in the Taiwan Strait - Jia-Jang Hung; Wan-Tzu Lu; Hsin-Mei Yang; Yen-Hui Lin; Laodong Guo (Frontiers in Marine Science, 2022)
This study examined the physical and biogeochemical processes that determine the spatial and summer/winter distributions of dissolved organic matter (DOM) and chromophoric dissolved organic matter (CDOM) in the Taiwan Strait (TS). The hydrological conditions in the TS varied between early summer and winter because of differences in terrestrial input as well as input from the poleward South China Sea Water (SCSW) during the warm summer and the strong, nutrient-rich, equatorward China Coastal Water (CCW) in winter. Concentrations of dissolved organic carbon (DOC) ranged from 60 to 100 μM-C in early summer and from 70 to 144 μM-C in winter. The average stoichiometric ratio of DOC : DON:DOP was high (353:49:1) in the land-source impacted zones and low (168:21:1) in the SCSW-laden areas, both of which are higher than the Redfield ratio. The concentrations of DOC and nutrients were higher in the western TS (on the coast of China) than in the eastern TS (on the coast of Taiwan), and the highest concentrations were mostly found in the Minjiang River plume, reflecting the profound effects of freshwater input in early summer and CCW inflow in winter. The absorption and emission characteristics of the CDOM varied to a large extent with locations because of the mixing of the shelf water with different source waters. Although the absorption coefficient (a CDOM (325)) and fluorescence intensity of the terrestrial humic-like CDOM (Ft: Ex/Em= 260/400-460) were both strongly inversely correlated with salinity, as an optical tracer, Ft may be more effective than a CDOM (325) in examining the mixing among source waters, given that a CDOM (325) may be subject to various photobleaching effects in the TS. Ft was also significantly correlated with the concentrations of terrestrially derived nitrate and nitrite (N+N) and silicate. The results of factor analysis elucidated the complexity of the hydrological and biological processes that affect the distributions of DOM and CDOM in the TS.

Regulation of enzymatic and non-enzymatic antioxidants in rice seedlings against chromium stress through sodium hydrosulfide and sodium nitroprusside - Yu-Juan Lin; Xing-Hui Feng; Yu-Xi Feng (Environmental Science and Pollution Research, 2022)

Protective effect of ginsenoside Rd on military aviation noise-induced cochlear hair cell damage in guinea pigs - Xue-min Chen; Yu-hui Liu; Shuai-fei Ji; Xin-miao Xue; Lin-lin Wang; Min Zhang; Yao-ming Chang; Xiao-cheng Wang (Environmental Science and Pollution Research, 2022)

Ginsenoside Rb1 inhibits oxidative stress-induced ovarian granulosa cell injury through Akt-FoxO1 interaction - Ping Zhou; Feng Deng; Zi Yang; Canhui Cao; Hongcui Zhao; Fenting Liu; Ke Zhong; Lin Fu; Tianliu Peng; Di Sun; Hui Liu; Rong Li; et al. (Science China Life Sciences, 2022)

Microfossil evidence of rice cultivation on the Southeast China Coast 7500 years ago - Xinxin Zuo; Jinqi Dai; Wei Wu; Jianhui Jin; Wei Ge; Yinping Wang; Lin Ren; Yingjun Lin; Yaoyao Pei; Hui Xie (Science China Earth Sciences, 2022)

Proteomic analysis and identification reveal the anti-inflammatory mechanism of clofazimine on lipopolysaccharide-induced acute lung injury in mice - Bo Yang; Zhan Gao; Qi-Shuang Li; Xiang-Ye Zhang; Lan Song; Yi-Ni Wang; Xin-Yue Wang; Lin-Lin Ji; Hong-Liang Xu; Hui Xie; Fu-Kai Feng; Xiao-Ping Li; et al. (Inflammation Research, 2022)

A histological study of vascular wall resident stem cells in venous malformations - Hou-Fu Xia; Wen-Qiang Lai; Gao-Hong Chen; Ye Li; Qi-Hui Xie; Yu-Lin Jia; Gang Chen; Yi-Fang Zhao (Cell and Tissue Research, 2022)

Complete genome sequence of Aconitum amalgavirus 1, a distinct member of the genus Amalgavirus - Jie Yang; Ping-Xiu Lan; Jin-Ming Li; Xiao-Jiao Chen; Guan-Lin Tan; Tai-Yun Wei; Ru-Hui Li; Fan Li (Archives of Virology, 2022)

Sphingomicrobium nitratireducens sp. nov., isolated from a tidal flat in Guangxi - Hao You; Lin Xu; Yan-Hui Kong; Cong Sun; Peng Zhou; Xue-Wei Xu (Archives of Microbiology, 2022)

The particle fluxes in sediment traps from Niulang Guyot area in the Northwest Pacific Ocean - Xiuwu Sun; Jinmin Chen; Baohong Chen; Cai Lin; Yang Liu; Jiang Huang; Zhong Pan; Kaiwen Zhou; Qing He; Fangfang Kuang; Hui Lin (Acta Oceanologica Sinica, 2022)

Nutrient distributions and nitrogen-anomaly (N*) in the tropical North Pacific Ocean - Aiqin Han; Yu Wang; Yunlong Huo; Cai Lin; Kaiwen Zhou; Fangfang Kuang; Hui Lin (Acta Oceanologica Sinica, 2022)

Baseline establishment for metals in the western Clarion-Clipperton Zone - Cai Lin; Yang Liu; Ronggen Jiang; Jinmin Chen; Baohong Chen; Weili Wang; Kaiwen Zhou; Hui Lin (Acta Oceanologica Sinica, 2022)

Experimental and theoretical analysis for the shear capacity of the square rebar reinforced concrete beams during the period of the Republic of China (1912–1949) - Chengwen Zhang; Qing Chun; Yijie Lin; Hui Jin; Yaohua Wang (European Journal of Environmental and Civil Engineering, 2022)

Two new physalins from Physalis alkekengi L. var. franchetii (Mast.) Makino - Jia-Min Sun; Ji-Xiang He; Min Huang; Hui-Xin Hu; Lin-Tao Xu; Kai-Li Fang; Xiao-Ning Wang; Tao Shen (Natural Product Research, 2022)

Xenoestrogen Status of Wuling Farm to Surrounding Water Bodies: An Application of Biochemical Parameters Using Onychostoma barbatulum - Lin-Yan Liao; Hui-Ling Cheng; Shu-Yin Wang; Shih-Hsiung Liang; Da-Ji Huang (Journal of Marine Science and Engineering, 2022)
The aim of this study was to apply biochemical parameters to Onychostoma barbatulum to understand whether Wuling Farm activities have caused organic pollution from xenoestrogens to flow into surrounding streams and thereby affected area aquatic ecosystems. Individuals of the Taiwan shovel-jaw carp (O. barbatulum) were collected by fyke netting in the Cijiawan, Kaoshan, and Yusheng Rivers in the protected area of Shei-Pa National Park and in the Ikawan River outside the protected areas from 4–5 June 2015 to 20–21 September 2015. The collected male individuals of O. barbatulum were divided into two groups. In the first group monooxygenase (Mon) activity, glutathione S-transferase (GST) activity, and vitellogenin (VTG) concentration in the liver were measured right after they were captured. Those in the second group were acclimated for 14 days and then exposed to 0 (control) or 10 ng/L 17β-estradiol for 10 days and then measured for changes in Mon, GST, and VTG in their livers. The value of VTG concentrations in O. barbatulum individuals collected from the Ikawan River was 2.12 ± 1.62 μg PO42+/g protein, which was the highest among all samples, followed by those collected from the Yusheng River (0.78 ± 1.00 μg PO42+/g protein). Individuals collected from the Yusheng River had the highest liver Mon activity (4.16 ± 1.08△A650/30 min/g protein) and the highest GST activity (1.58 ± 1.13 △A340/20 min/g protein), followed by those from the Ikawan River (Mon: 3.63 ± 1.13 △A650/30 min/g protein; GST: 1.24 ± 0.73 △A340/20 min/g protein). Comprehensive analyses showed that Mon and GST activities and VTG concentrations in livers measured right after being collected were lower than individuals exposed to 10 ng 17β-estradiol/L in the laboratory. Induced VTG concentrations were 9.87 ± 0.89 μg PO42+/g protein, Mon activity 8.02 ± 1.74 △A650/30 min/g protein, and GST activity 3.24 ± 0.62 △A340/20 min/g protein, indicating that farming activities have not significantly affected these aquatic organisms. However, pollution sources are still releasing pollutants containing xenoestrogens into the Yusheng River and Ikawan River. The impact of xenoestrogens is worthy of continuous long-term follow-up monitoring.

Depletion of serum-derived exosomes aggravates heat stress-induced damage of bovine mammary epithelial cells - Yue Wang; Hui-Li Wang; Zhi-Ping Lin; Ji-Feng Zhong; Kun-Lin Chen; Xing Duan (Molecular Biology Reports, 2022)

Temperature has a strong impact on the abundance and community structure of comammox Nitrospira in an Ultisol - Mengmeng Feng; Zi-Yang He; Jianbo Fan; An-Hui Ge; Shengsheng Jin; Yongxin Lin; Ji-Zheng He (Journal of Soils and Sediments, 2022)

Theranostic Radiolabeled Nanomaterials for Molecular Imaging and potential Immunomodulation Effects - Chao-Cheng Chen; Yang-Hsiang Chan; Syue-Liang Lin; Huihua Kenny Chiang; Yi-Jang Lee; Hui-Yen Chuang (Journal of Medical and Biological Engineering, 2022)

Identification of a 5-gene-risk score model for predicting luminal A-invasive lobular breast cancer survival - Yi-Huan Chen; Tao-Feng Zhang; Yi-Yuan Liu; Jie-Hua Zheng; Wei-Xun Lin; Yao-Kun Chen; Jie-Hui Cai; Juan Zou; Zhi-Yang Li (Genetica, 2022)

Dynamic response and failure evolution of low-angled interbedding soft and hard stratum rock slope under earthquake - Jun Feng; Yingbin Zhang; Jianxian He; Hui Zhu; Lin Huang; Wentao Mao; Haiying Fu; Dejian Li (Bulletin of Engineering Geology and the Environment, 2022)

Functional characterization of two homologs of yeast acetyl-coenzyme A synthetase in the entomopathogenic fungus Beauveria bassiana - Jia-Hui Lei; Hai-Yan Lin; Jin-Li Ding; Ming-Guang Feng; Sheng-Hua Ying (Archives of Microbiology, 2022)

Microbial transformation of distinct exogenous substrates into analogous composition of recalcitrant dissolved organic matter - Jie Lian; Xiaoxuan Zheng; Xiaocun Zhuo; Yi‐Lung Chen; Chen He; Qiang Zheng; Ta‐Hui Lin; Jia Sun; Weidong Guo; Quan Shi; Nianzhi Jiao; Ruanhong Cai (Environmental Microbiology, 2022)

Gregarious larval settlement mediates the responses of new recruits of the reef coral Acropora austera to ocean warming and acidification - Lei Jiang; Yu-Yang Zhang; Cheng-Yue Liu; Lin-Tao Huang; Hao-Ya Tong; Guo-Wei Zhou; Ming-Lan Guo; Tao Yuan; Hui Huang (Frontiers in Marine Science, 2022)
Gregarious larval settlement represents an important window for chimera formation in reef corals, yet it remains largely unknown how aggregated settlement and early chimerism could modify the performance and responses of coral recruits under elevated temperature and p CO 2 . In this study, single and aggregated recruits of the broadcast spawning coral Acropora austera were exposed to contrasts of two temperatures (28 versus 30.5°C) and p CO 2 levels (~500 versus 1000 μatm) for two weeks, and algal symbiont infection success, survivorship and growth were assessed. Results showed that symbiont infection success was mainly affected by temperature and recruit type, with reduced symbiont infection at increased temperature and consistently higher infection success in chimeric recruits compared to single recruits. Furthermore, although chimeric recruits with larger areal size had significantly higher survivorship in all treatments, the polyp-specific growth rates were considerably lower in chimeric entities than individual recruits. More importantly, the recruit type significantly influenced the responses of recruit polyp-specific growth rates to elevated temperature, with chimeras exhibiting lowered skeletal lateral growth under elevated temperature. These results demonstrate the benefits and costs associated with gregarious larval settlement for juvenile corals under ocean warming and acidification, and highlight the ecological role of larval settlement behavior in mediating the responses of coral recruits to climate change stressors.

An automatic method to generate voxel-based absorbed doses from radioactivity distributions for nuclear medicine using generative adversarial networks: a feasibility study - Hui Lin; Xin Guo; Jia Jing; Xiaoli Mao; Yuanjun Yang; Min Hu (Physical and Engineering Sciences in Medicine, 2022)

ZAKβ Alleviates Oxidized Low-density Lipoprotein (ox-LDL)-Induced Apoptosis and B-type Natriuretic Peptide (BNP) Upregulation in Cardiomyoblast - Yueh-Min Lin; Jiro Hasegawa Situmorang; Jia-Zun Guan; Dennis Jine-Yuan Hsieh; Jaw-Ji Yang; Michael Yu-Chih Chen; Ching-Hui Loh; Chia-Hua Kuo; Shang-Yeh Lu; Ying-Ming Liou; Chih-Yang Huang (Cell Biochemistry and Biophysics, 2022)

Paleo-karst zone and its control on reservoirs in the fourth member of the Sinian Dengying formation in the Moxi area, central Sichuan Basin - Qinyu Xia; Haijun Yan; Wei Xu; Lin Zhang; Qian Li; Wenjun Luo; Hui Deng; Xun Zhu; Xinyu Li; Jichen Yu (Carbonates and Evaporites, 2022)

Insulin growth factor-1 enhances proliferation and inhibits apoptosis of neural progenitor cells by phosphorylation of Akt/mTOR/p70S6K molecules and triggering intrinsic apoptosis signaling pathway - Bo Zhang; Lingyun Hu; Jianying Zhang; Hui Wu; Wei Li; Lin Gou; Hao Liu (Cell and Tissue Banking, 2022)

Ancylostoma ceylanicum Infection in a Miniature Schnauzer Dog Breed - Xu-Hui Lin; Hai-Ming Cai; Zhuan-Qiang Yan; Shen-Quan Liao; Min-Na Lv; Cai-Yan Wu; Juan Li; Jun-Jing Hu; Wen-Wan Xiao; Jian-Fei Zhang; Nan-Shan Qi; Ming-Fei Sun (Acta Parasitologica, 2022)

Coastal aquaculture farms for the sea cucumber Apostichopus japonicus provide spawning and first-year nursery grounds for wild black rockfish, Sebastes schlegelii: A case study from the Luanhe River estuary, Bohai bay, the Bohai Sea, China - Min Xu; Zun-li Qi; Zun-lei Liu; Wei-min Quan; Qi Zhao; Yun-ling Zhang; Hui Liu; Lin-lin Yang (Frontiers in Marine Science, 2022)
Aquaculture farms are known to attract wild organisms from nearby areas. Sea cucumber Apostichopus japonicus aquaculture farms in Bohai Bay, the Bohai Sea, China, might provide spawning and nursery grounds for wild black rockfish Sebastes schlegelii populations. To identify the above, we studied the variation in the numbers of S. schlegelii larvae (and length-categories as a percentage of the natural population) via ichthyoplankton surveys by months from January to October 2020, and assessed the food web structure and energy flow distribution of the farm and trophic links of S. schlegelii natural stock by using Ecopath modeling in July 2016 to August 2017. Larvae with a length between 3.90-5.80 mm were observed in the farm in May 2020, the juveniles with an estimated trophic level of 4.31. Juveniles used the farms as first-year nursery ground, and then they swam into deeper waters in August of the following year. MTI analysis showed increasing biomass of S. schlegelii might result in a decrease in the biomass of crustacea, and had positive and negative impacts on mollusk and Hexagrammos otakii biomass. We argued that aquacultural infrastructures constructed by artificial reefs could be used as a fisheries management tool to enhance S. schlegelii stocks and that monitoring of other marine organisms, such as oysters, Rapana venosa , Charybdis japonica , and Asterias spp. etc., was necessary to maintain sustainable exploitations of aquacultural farm ecosystems. A paucity of knowledge surrounding the interactions between aquaculture farms and wild organisms needs furthermore researches.

Lignans and phenylpropanoids from the roots of Ficus hirta and their cytotoxic activities - Xian-Sheng Ye; Wen-Jing Tian; Xiang-Zhong Liu; Mi Zhou; De-Quan Zeng; Ting Lin; Guang-Hui Wang; Xin-Sheng Yao; Hai-Feng Chen (Natural Product Research, 2022)

CREB1 contributes colorectal cancer cell plasticity by regulating lncRNA CCAT1 and NF-κB pathways - Bin Li; Lisi Zheng; Jiayi Ye; Chenmin Zhang; Jie Zhou; Qiaojuan Huang; Yanhua Guo; Luqin Wang; Peng Yu; Shurong Liu; Qiao Lin; Yuxia Luo; et al. (Science China Life Sciences, 2022)

Understorey light environment impacts on seedling establishment and growth in a typhoon-disturbed tropical forest - Kuo-Jung Chao; Yung-Chiau Lin; Guo-Zhang Michael Song; Chien-Hui Liao; Yau-Lun Kuo; Chang-Fu Hsieh; Eugene W. Schupp (Plant Ecology, 2022)

Ginsenoside Rb3 attenuates skin flap ischemia-reperfusion damage by inhibiting STING-IRF3 signaling - Yuanbin Li; Haifen Liu; Zhaohui Zeng; Hui Lin; Xin Chen; Xianglian Yuan; Jizhe Qiu; Fengchun Fu; Zhuang Chen; Jianjun Kuang (Journal of Molecular Histology, 2022)

Biomechanical Effects of Bone Atrophy, Implant Design, and Vertical or Tilted of Posterior Implant on All-on-Four Concept Implantation: Finite Element Analysis - Heng-Li Huang; Ting-Wei Lin; Hui-Ling Tsai; Yu-Ling Wu; Aaron Yu-Jen Wu (Journal of Medical and Biological Engineering, 2022)

Effectiveness of allyl isothiocyanate microencapsulated in polyethylene as a repellent against Solenopsis invicta (Hymenoptera: Formicidae) infestation of corrugated cardboard boxes in field experiment - Yoshiaki Hashimoto; Hironori Sakamoto; Hiromi Asai; Masamitsu Yasoshima; Hui-Min Lin; Koichi Goka (Applied Entomology and Zoology, 2022)
Solenopsis invicta Buren (Hymenoptera: Formicidae; red imported fire ant) is an invasive species in several parts of the world. A major contributor to the spread of S. invicta is infested shipping containers. The vapor of allyl isothiocyanate (AITC), a naturally occurring organosulfur compound, is highly toxic to S. invicta ; however, AITC is highly volatile. Microencapsulation of AITC in polyethylene (PE) resin slows the release of AITC, making it a potentially useful material for preventing S. invicta infestations. Here, we examined the efficacy of AITC microencapsulated in PE (mAITC) as a repellent against S. invicta infestation of cardboard boxes, a common containerized cargo. Using baited cardboard boxes, we found that the number of S. invicta individuals entering boxes containing an mAITC sheet was significantly less than that entering boxes without an mAITC sheet. When a PE cover, which is often used to protect carboard boxes during shipping, was used, vapor concentrations of AITC inside the boxes were increased and the number of S. invicta individuals entering the boxes was reduced almost to zero. These findings indicate that mAITC sheeting, especially in combination with a PE cover, is a promising material for the protection of containerized cardboard-box cargo against S. invicta infestation.

Plant secondary metabolite and temperature determine the prevalence of Arsenophonus endosymbionts in aphid populations - Chun‐Yan Chang; Xiao‐Wan Sun; Pan‐Pan Tian; Ning‐Hui Miao; Yu‐Lin Zhang; Xiang‐Dong Liu (Environmental Microbiology, 2022)
Summary Transmission rate and role in hosts contribute to the prevalence of an endosymbiont. However, factors affecting transmission and role of facultative endosymbionts are still not well understood. Here, we illustrated that host plants and environmental temperatures affected the transmission, relative abundance and role of Arsenophonus in the cotton aphid Aphis gossypii . The transmission rate of this endosymbiont from mother aphids to offspring was relatively lower. High temperatures impeded the transmission, and infection rates declined as aphids were exposed to 30°C. Contents of amino acids and secondary metabolites were remarkably different among host plants. Aphids feeding on zucchini leaves containing a higher titre of amino acids and lower secondary metabolites harboured a relatively lower abundance of Arsenophonus . Concentrations of an amino acid and a plant secondary metabolite, cucurbitacin B, in aphid diet were not associated with Arsenophonus abundance. However, gossypol, another plant secondary metabolite, was strongly related with the abundance. Arsenophonus imparted a fitness benefit to aphids, and the benefit was dependent on host plants and gossypol concentration. In sum, plant secondary metabolite and environmental temperature affect transmission, relative abundance and role of Arsenophonus , which determine the endosymbiont prevalence in aphid populations.

Systematic contributions of CFEM domain‐containing proteins to iron acquisition are essential for interspecies interaction of the filamentous pathogenic fungus Beauveria bassiana - Yue‐Jin Peng; Jia Hou; Hao Zhang; Jia‐Hui Lei; Hai‐Yan Lin; Jin‐Li Ding; Ming‐Guang Feng; Sheng‐Hua Ying (Environmental Microbiology, 2022)
Summary Common in fungal extracellular membrane (CFEM) domain is unique in fungal proteins and some of which contribute to iron acquisition in yeast. However, their roles in iron acquisition remain largely unknown in filamentous fungi. In this study, 12 CFEM‐containing proteins were bioinformatically identified in the filamentous entomopathogenic fungus Beauveria bassiana , and the roles of 11 genes were genetically characterized. Transmembrane helices were critical for their association with intracellular membranes, and their number varied among proteins. Eleven CFEM genes significantly contribute to vegetative growth under iron starvation and virulence. Notably, the virulence of most disruptants could be significantly weakened by a decrease in iron availability, in which the virulence of Δ Bbcfem7 and 8 strains was partially recovered by exogenous hemin. Δ Bbcfem7 and 8 mutants displayed defective competitiveness against the sister entomopathogenic fungus Beauveria brongniartii . All 11 disruptants displayed impaired growth in the antagonistic assay with the saprotrophic fungus Aspergillus niger , which could be repressed by exogenous ferric ions. These findings not only reveal the systematic contributions of CFEM proteins to acquire two forms of iron (i.e. heme and ferric ion) in the entire lifecycle of entomopathogenic fungi but also help to better understand the mechanisms of fungus–host and inter–fungus interactions.

Research on an Extensible Monitoring System of a Seafloor Observatory Network in Laizhou Bay - Jie Chen; Hailin Liu; Bin Lv; Chao Liu; Xiaonan Zhang; Hui Li; Lin Cao; Junhe Wan (Journal of Marine Science and Engineering, 2022)
An extensible remote monitoring system for a seafloor observatory network in Laizhou Bay was established to realize long-term, continuous and on-line monitoring for a marine ranching environment. This paper deals with data communication, device management and data quality control. A control model is introduced that is structured into four layers, enabling bidirectional information flow. Based on the control model, the standardized communication protocol and device object model-oriented dynamic management method are designed as plug-and-play, for data processing and control of a large number of devices. An improved data quality control method is proposed to reduce the data error rate. The monitoring system was developed based on socket network programming, MySQL database technologies and modular ideas. The seafloor observatory network was successfully deployed in Laizhou Bay marine ranching. The experimental results demonstrate that the monitoring system obtains better performance. The proposed algorithms can also be used in many other similar systems with adaptive requirements.

Correction to: Matrine Treatment Blocks NogoA-Induced Neural Inhibitory Signaling Pathway in Ongoing Experimental Autoimmune Encephalomyelitis - Quan-Cheng Kan; Hui-Jun Zhang; Yuan Zhang; Xing Li; Yu-Ming Xu; Rodolfo Thome; Ming-Liang Zhang; Nan Liu; Yao-Juan Chu; Guang-Xian Zhang; Lin Zhu (Molecular Neurobiology, 2022)

Context-dependent effects of inflammation on retina regeneration - Cuiping Zhou; Xiaoli Zhang; Yuxi Chen; Zihao Lin; Shuqiang Zhang; Zhiqiang Zhang; Lining Cao; Huaijin Guan; Jianfeng Lu; Hui Xu (Molecular Neurobiology, 2022)

PPARγ Dysfunction in the Medial Prefrontal Cortex Mediates High-Fat Diet-Induced Depression - Cong-Cong Fu; Xin-Yi Zhang; Liu Xu; Hui-Xian Huang; Shuang Xu; Qiao-Qi Wu; Zhen Wang; Xi Gu; Li-Fang Lin; Song Lin; Ying-Ying Fang; Xiong Cao; et al. (Molecular Neurobiology, 2022)

Transformation of HBCDs by Rhodococcus sp. stu-38 - Fei Yu; Wenqi Luo; Yuyang Li; Shanshan Meng; Xianbin Lin; Lele Li; Xueying Ye; Hui Wang; Tao Peng; Tongwang Huang; Zhong Hu (Current Microbiology, 2022)

High Levels of 25-OH-Vitamin D and Copper in Pregnant Women with Abnormal Glucose Challenge Test - Chien-Hua Chiang; Wan-Ju Kung; Chien-Hung Lee; Yeong-Hwa Zen; Cheng-Fa Lee; Hui-Ru Yang; Ching-Chiang Lin; Yeou-Lih Huang (Biological Trace Element Research, 2022)

Streptococcus vulneris sp. nov., isolated from wound of patient with diabetic foot ulcer (DFU) - Jen-hao Chung; Li-Ting Wang; Yi-Sheng Chen; Yun-Shien Lee; Shih-Ting Lin; Yu-Chung Chang; Hui-Chung Wu; Yu-Jie Dai; Wei-Qi Liao; Fan-Ching Kao; Jui-hsiang Li (Archives of Microbiology, 2022)

Hasubanan alkaloids with anti-inflammatory activity from Stephania longa - Hui Liu; Wan-Qin Liao; Rong-Xiao Lin; Lixia Fan; Jinyan Sun; Hong-Yuan Chen; Fang Liu; An-Ping Yang (Natural Product Research, 2022)

Identification of the Largest SCA36 Pedigree in Asia: with Multimodel Neuroimaging Evaluation for the First Time - Yue Xie; Zhao Chen; Zhe Long; Rui-Ting Chen; Yi-Zheng Jiang; Ming-Jie Liu; Lin-Liu Peng; Hui-Rong Peng; Na Wan; Guangdong Zou; Chun-Rong Wang; Yu-Ting Shi; et al. (The Cerebellum, 2022)

Activation of Neuropeptide Y2 Receptor Can Inhibit Global Cerebral Ischemia-Induced Brain Injury - Reggie Hui-Chao Lee; Celeste Yin-Chieh Wu; Cristiane T. Citadin; Alexandre Couto e Silva; Harlee E. Possoit; Garrett A. Clemons; Christina H. Acosta; Victoria A. de la Llama; Jake T. Neumann; Hung Wen Lin (NeuroMolecular Medicine, 2022)

Bedside Diagnosis for Disseminated Deep Dermatophytosis: a Case Series Study - Xiu-Jiao Xia; Hong Shen; Hui-Lin Zhi; Yan Zhong; Bo Sang; Wen-Wen Lv; Qiu-Ping Li; Ze-Hu Liu (Mycopathologia, 2022)

Association between MAP3K4 gene polymorphisms and the risk of schizophrenia susceptibility in a Northeast Chinese Han population - Yang Sun; Ye Lv; Hui-Wen Ren; Guan-Yu Wang; Li-Na Xuan; Yi-Yang Luo; Zhi-Lin Luan (Metabolic Brain Disease, 2022)

TREM-2 mediates dendritic cell–induced NO to suppress Th17 activation and ameliorate chronic kidney diseases - Ching-Cheng Lin; Ti-Yung Chang; Yong-Chen Lu; Yun-Syuan Wu; Wei Huang; Wei-Chi Lo; Guan-Fu Liu; Wei-Chan Hsu; Pamela S. Ohashi; Tak W. Mak; Jong-Ling Fuh; Hui-Chen Chen; et al. (Journal of Molecular Medicine, 2022)

Use of piggyBac Transposon System Constructed Murine Breast Cancer Model for Reporter Gene Imaging and Characterization of Metastatic Tumor Cells - Ying-Ling Chen; Yung-Cheng Wang; Kuei-Yuan Hou; Min-Ying Lin; Yu-Chuan Lin; Hui-Yen Chuang; Yi-Jang Lee (Journal of Medical and Biological Engineering, 2022)

Long-term exercise pre-training attenuates Alzheimer’s disease–related pathology in a transgenic rat model of Alzheimer’s disease - Luodan Yang; Chongyun Wu; Yong Li; Yan Dong; Celeste Yin-Chieh Wu; Reggie Hui-Chao Lee; Darrell W. Brann; Hung Wen Lin; Quanguang Zhang (GeroScience, 2022)

A dose- and time-dependent effect of oxythiamine on cell growth inhibition in non-small cell lung cancer - Lin Bai; Hui-li Zhu (Cognitive Neurodynamics, 2022)
The high mortality rate of non-small-cell lung cancer (NSCLC) is mostly due to the high risk of recurrence. A comprehensive understanding of proliferation mechanisms of NSCLC would remarkably contribute to blocking up the invasion and metastasis of tumor cells. In our previous study, the remarkable decreased activity of Thiamine-dependent enzymes (TDEs), involving in intermediary metabolism responsible for energy production of tumor, was found under conditions of thiamine deficiency in vivo. To explore the effect of Oxythiamine (OT), a TDEs antimetabolite, on cell growth, we co-cultured A549 cells with OT in vitro at various doses (0.1, 1, 10 and 100 μM) and time periods (6, 12, 24 and 48 h) and subsequent cell proliferation and apoptosis assays were performed respectively. Our findings demonstrated that A549 cells proliferation was significantly downregulated by OT treatment in a progressively dose as well as time dependent manner. Inhibition of TDEs resulted in antagonism of lung cancer growth by inducing cells to cease the cycle as well as apoptotic cell death. We concluded a critical role of OT, a TDEs antagonistic compound, indicating the potential target of its practical use.

Flow-slide characteristics and failure mechanism of shallow landslides in granite residual soil under heavy rainfall - Hui-lin Bai; Wen-kai Feng; Shuang-quan Li; Long-zhen Ye; Zhong-teng Wu; Rui Hu; Hong-chuan Dai; Yun-peng Hu; Xiao-yu Yi; Peng-cheng Deng (Journal of Mountain Science, 2022)

The optimal combination of Nile red identification, colony polymerase chain reaction, and gas chromatography detection methods in screening for polyhydroxyalkanoicate-producing bacteria - Hung-Che Chou; Chia-Hsin Chen; Hsiao-Kai Chu; Chun-Mei Huang; Hui-Jun Wang; Wei-Lin Tu; Gia-Luen Guo (Archives of Microbiology, 2022)

Intelligent identification method and application of seismic faults based on a balanced classification network - Jing Yang; Ren-Wei Ding; Hui-Yong Wang; Nian-Tian Lin; Li-Hong Zhao; Shuo Zhao; Yu-Jie Zhang (Applied Geophysics, 2022)

Exploiting Sentinel-1 data and machine learning–based random forest for collectively mapping rice fields in Taiwan - Nguyen-Thanh Son; Chi-Farn Chen; Cheng-Ru Chen; Youg-Sin Cheng; Piero Toscano; Chein-Hui Syu; Horng-Yuh Guo; Shu-Ling Chen; Tsang-Sen Liu; Yi-Ting Zhang; Huan-Sheng Lin; Shih-Hsiang Chen; et al. (Applied Geomatics, 2022)

Natural component plumbagin as a potential antibacterial agent against Streptococcus agalactiae infection - Ai‐Guo Huang; Lin‐Jun Su; Wei‐Hao He; Fa‐Li Zhang; Chao‐Shuai Wei; Ying‐Hui Wang (Journal of Fish Diseases, 2022)
Streptococcus agalactiae , also known as Group B Streptococcus (GBS), can infect humans, terrestrial animals and fish. The emergence of bacterial resistance of S. agalactiae to antibiotics leads to an urgent need of exploration of new antimicrobial agents. In the study, the antibacterial activity of natural component plumbagin (PLB) against S. agalactiae was investigated in vitro and in vivo. The results showed that the minimal inhibitory concentration (MIC) of PLB against S. agalactiae was 8 mg/L. The growth curve assay revealed that PLB could inhibit the growth of S. agalactiae . In addition, the time‐killing curve showed that S. agalactiae was killed almost completely by 2‐fold MIC of PLB within 12 h. Transmission electron microscopy results showed obvious severe morphological destruction and abnormal cells of S. agalactiae after treated with PLB. The pathogenicity of S. agalactiae to zebrafish was significantly decreased after preincubation with PLB for 2 h in vitro, further indicating the bactericidal activity of PLB. Interestingly, PLB could kill S. agalactiae without inducing resistance development. Furthermore, pretreatment and post‐treatment assays suggested that PLB also exhibited the antibacterial activity against S. agalactiae infection in vivo by effectively reducing the bacterial load and improving the survival rate of S. agalactiae ‐infected zebrafish. In summary, PLB had potent antibacterial activity against S. agalactiae in vitro and in vivo, and it could be an excellent antimicrobial candidate to prevent and control S. agalactiae infection.

Geochemistry and geochronology of early Palaeozoic seamount in Western Kunlun orogenic belt and the tectonic implications - Chen Yang; Yunpeng Dong; Hui Wang; Zhongyue Lin; Youyun Liao; Shangpeng Zhang; Huan Liu (International Geology Review, 2022)

Complete genome sequence of a novel chlorobenzene degrader, Burkholderia stabilis TF-2 - Xiao-Ping Zhang; Yan-Hui Gao; Zhi-Lin Xing; Yong-Qiong Wang; Tian-Tao Zhao (Biologia, 2022)

Development of novel polymorphic microsatellite markers for Picea brachytyla - Shuai-Peng Si; Chun-Jing Wang; Ji-Zhong Wan; Yu-Lin Qian; Chun-Hui Zhang (Molecular Biology Reports, 2022)

Metabolic properties, gene functions, and biosafety analysis reveal the action of three rhizospheric plant growth-promoting bacteria of Jujuncao (Pennisetum giganteum) - Richard Yankey; Ibrahim N. A. Omoor; Joseph K. Karanja; Lifang Wang; Regassa Terefe Urga; Chew Hui Fang; Lin Dongmei; Hui Lin; Jacob Eyalira Okal; Ibrahim Lawandi Datti; Aimable Nsanzinshuti; Christopher Rensing; et al. (Environmental Science and Pollution Research, 2022)

Spatial–temporal patterns of summer urban islands and their economic implications in Beijing - Lu Lin; Lina Meng; Yingdan Mei; Wenting Zhang; Hui Liu; Weiling Xiang (Environmental Science and Pollution Research, 2022)

The roles of leaf area index and albedo in vegetation induced temperature changes across China using modelling and observations - Na Dong; Ming Luo; Zhen Liu; Junying Sun; Kailu Wu; Hui Lin (Climate Dynamics, 2022)

Two new 7,20-epoxy- ent -kaurane diterpenoids from the aerial parts of Isodon serra - Juan-Juan Hu; Bai-Lin Li; Jin-Dan Xie; Hui-Jun Liang; Qian-Ran Li; Jie Yuan; Jie-Wei Wu (Natural Product Research, 2022)

Seasonal Distributions of Methane in a Populous Urban Coastal Sea Area - Hsiao-Chun Tseng; Chia-Chia Lin; Hui-Juan Pan; Yokie Tai Yuh Han; Gwo-Ching Gong (Frontiers in Marine Science, 2022)
Methane (CH 4 ) is an important greenhouse gas, and its concentrations in aquatic areas are heavily influenced by anthropogenic activities, especially human-induced eutrophication, polluted river discharge and wastewater treatment plant (WWTP) effluents. Although coastal areas and estuaries contribute large amounts of global oceanic CH 4 emissions, the relative contributions of different sources have not been well determined. The Tamsui River located in northern Taiwan is an urban river flowing through populated cities and thus likely carries large amounts of contaminants, such as nutrients and organic matter to the estuary. In this study, we characterized the spatial distribution and seasonal variations in CH 4 in the Tamsui River estuary adjacent marine areas. The sea-to-air CH 4 fluxes were also estimated to quantify the strength of the study area as an atmospheric CH 4 source. Our results showed that CH 4 concentrations in coastal sea areas were influenced by WWTP effluents, sediment and freshwater inputs. Thus, river discharge and nutrient levels as well as strong vertical mixing and disturbances might increase CH 4 concentrations and emissions. The seasonal surface CH 4 concentrations and sea-to-air CH 4 fluxes were 13.7 ± 18.7 nM and 41.7 ± 68.0 μmol m -2 d -1 in autumn; 29.3 ± 19.8 nM and 61.3 ± 44.6 μmol m -2 d -1 in spring; 21.8 ± 13.9 nM and 37.0 ± 26.2 μmol m -2 d -1 in summer; and 27.0 ± 21.4 nM and 85.9 ± 75.4 μmol m -2 d -1 in winter.

Reproductive strategies of Xanthium italicum differ from those of native Xanthium sibiricum, and they are key to its invasiveness - Meng Jiang; Miao Ma; Hui Lin; Xia Ma (Plant Ecology, 2022)

Dissecting the Neural Circuitry for Pain Modulation and Chronic Pain: Insights from Optogenetics - Fang Guo; Yu Du; Feng-Hui Qu; Shi-Da Lin; Zhong Chen; Shi-Hong Zhang (Neuroscience Bulletin, 2022)
Pain is an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage. The processing of pain involves complicated modulation at the levels of the periphery, spinal cord, and brain. The pathogenesis of chronic pain is still not fully understood, which makes the clinical treatment challenging. Optogenetics, which combines optical and genetic technologies, can precisely intervene in the activity of specific groups of neurons and elements of the related circuits. Taking advantage of optogenetics, researchers have achieved a body of new findings that shed light on the cellular and circuit mechanisms of pain transmission, pain modulation, and chronic pain both in the periphery and the central nervous system. In this review, we summarize recent findings in pain research using optogenetic approaches and discuss their significance in understanding the pathogenesis of chronic pain.

Genetic diversity and population structure of Curcuma alismatifolia Gagnep. accessions revealed by SSR markers - Hui-Wen Yu; Ling-Jun Ke; Yi-Lan Xiao; Si-Jia Chen; Yuan-Yuan Li; Qi-Lin Tian; Yun-He Li; Jin-Shui Lin; Luan-Mei Lu (Genetic Resources and Crop Evolution, 2022)

Correction to: Coupling coordination analysis of China’s provincial water‑energy‑food nexus - Yingying Qi; Arash Farnoosh; Lu Lin; Hui Liu (Environmental Science and Pollution Research, 2022)

Coupling coordination analysis of China’s provincial water-energy-food nexus - Yingying Qi; Arash Farnoosh; Lu Lin; Hui Liu (Environmental Science and Pollution Research, 2022)

Investigation on grouting diffusion in inclined fracture with flowing water conditions - Jia-fan Zhang; Xun-xun Chen; Yang Liu; Hui-mei Zhang; Chun-lin Wang; Gang Fang (Arabian Journal of Geosciences, 2022)

Anti-inflammatory constituents from Phyllostachys makinoi Hayata - Chia-Ching Liaw; Yu-Chi Lin; Shao-Yu Wu; Jenny Chun-Ling Kuo; Zhi-Hu Lin; Kai-Wei Lin; Huang Hui-Chi; Li-Ming Yang Kuo; Yao-Haur Kuo (Natural Product Research, 2022)

Structural and Functional Improvements of Coastal Ecosystem Based on Artificial Oyster Reef Construction in the Bohai Sea, China - Xu Wang; Jie Feng; Chenggang Lin; Hui Liu; Muyan Chen; Yunling Zhang (Frontiers in Marine Science, 2022)
Oyster reefs are gaining more and more attention in marine ranching and coastal ecosystem restoration, but tremendous knowledge gaps still exist. In this study, we developed trophic models for the established artificial oyster reef (EAOR), newly deployed artificial oyster reef (NAOR), and non-reef bare substratum (NBS) ecosystems located in the Bay of Xiangyun, Bohai Sea, China, to assess the benefits of artificial oyster reef construction and to characterize the unique role of these reefs in coastal management. The analysis showed that the EAOR and NAOR ecosystems were similar to each other, but both were greatly different than the NBS ecosystem. Reefs showed greater “ecological size” and stronger top-down effects compared to the bare area. The ecosystems were not yet mature, but the EAOR and NAOR ecosystems had more complicated trophic relationships, greater potential to withstand perturbations, and higher biological carrying capacities of commercial organisms compared to the NBS ecosystem. These results demonstrated that artificial oyster reef construction resulted in great advantages to the ecosystem. For example, oysters became the structuring functional group and played a critical role in the trophic structure of the reef areas. The phytoplankton/detritus-oysters-carnivorous macrobenthos pathway developed and became dominant in these areas, thereby contributing to highly efficient secondary production. The ratios of total primary production/total respiration were < 1, indicating that the reef ecosystems responded effectively to nutrient inputs from adjacent ecosystems. We speculate that water exchange might be a critical factor influencing the maintenance of the system. Long-term monitoring of the EAOR and NAOR should be implemented for oyster protection and to assess the need to manipulate carnivorous macrobenthos to keep the systems in balance. Results of this study could benefit the restoration, exploitation, and management of oyster reefs. Further studies should take the adjacent ecosystems and anthropogenic activities into account.

The management of bone defect using long non-coding RNA as a potential biomarker for regulating the osteogenic differentiation process - Jia-lin Liu; Yan-shi Liu; Mei-jie Zheng; Hui-yu He (Molecular Biology Reports, 2022)
Tissue engineered bone brings hope to the treatment of bone defects, and the osteogenic differentiation of stem cells is the key link. Inducing osteogenic differentiation of stem cells may be a potential approach to promote bone regeneration. In recent years, lncRNA has been studied in the field increasingly, which is believed can regulate cell cycle, proliferation, metastasis, differentiation and immunity, participating in a variety of physiology and pathology processes. At present, it has been confirmed that certain lncRNAs regulate the osteogenesis of stem cells and take part in mediating signaling pathways including Wnt/β-catenin, MAPK, TGF-β/BMP, and Notch pathways. Here, we provided an overview of lncRNA, reviewed its researches in the osteogenic differentiation of stem cells, emphasized the importance of lncRNA in bone regeneration, and focused on the roles of lncRNA in signaling pathways, in order to make adequate preparations for applying lncRNA to bone tissue Engineering, letting it regulate the osteogenic differentiation of stem cells for bone regeneration.

Hippocampal SIRT1-Mediated Synaptic Plasticity and Glutamatergic Neuronal Excitability Are Involved in Prolonged Cognitive Dysfunction of Neonatal Rats Exposed to Propofol - Lin-Hui Ma; Jie Wan; Jing Yan; Ning Wang; Yan-Ping Liu; Hai-Bi Wang; Cheng-Hua Zhou; Yu-Qing Wu (Molecular Neurobiology, 2022)

Eichleriella aculeobasidiata sp. nov. (Auriculariales, Basidiomycota) evidenced by morphological characters and phylogenetic analyses in China - Hui Wang; Dong-Qiong Wang; Chang-Lin Zhao (Kew Bulletin, 2022)

Fate of heavy metals and bacterial community composition following biogas slurry application in a single rice cropping system - Qiang Wang; Zhaoming Chen; Jun Zhao; Junwei Ma; Qiaogang Yu; Ping Zou; Hui Lin; Jinchuan Ma (Journal of Soils and Sediments, 2022)

Decreased glomalin-related soil protein with nitrogen deposition in a 3-year-old Cunninghamia lanceolata plantation - Shuxian Jia; Xiaofei Liu; Weisheng Lin; Yong Zheng; Jianwei Li; Dafeng Hui; Jianfen Guo (Journal of Soils and Sediments, 2022)

The Emerging Biotherapeutic Agent: Akkermansia - Vipin Chandra Kalia; Chunjie Gong; Ramasamy Shanmugam; Hui Lin; Liaoyuan Zhang; Jung-Kul Lee (Indian Journal of Microbiology, 2022)

Unloading Response Characteristics of Cross Fault Caverns: Effect of Fault Angles - Yong-Hui Shang; Lin-Rong Xu; Yong-Wei Li (Geotechnical and Geological Engineering, 2022)

The effect of preoperative statin treatment on acute kidney injury in elderly patients undergoing valve replacement surgery - Bing-qi Fu; Xue-biao Wei; Zedazhong Su; Ying-wen Lin; Zu-hui Ke; Tong Tan; Ji-yan Chen; Shou-hong Wang; Dan-qing Yu (European Journal of Clinical Pharmacology, 2022)

Selenium Deficiency Leads to Changes in Renal Fibrosis Marker Proteins and Wnt/β-Catenin Signaling Pathway Components - Tingting Lin; Jiaqi Tao; Ying Chen; Yitong Zhang; Fenglan Li; Yutong Zhang; Xueqing Han; Zihui Zhao; Guiyan Liu; Hui Li (Biological Trace Element Research, 2022)

Endosomal sorting complexes required for transport‐0 ( ESCRT ‐0) are essential for fungal development, pathogenicity, autophagy and ER ‐phagy in Magnaporthe oryzae - Li‐Xiao Sun; Hui Qian; Meng‐Yu Liu; Ming‐Hua Wu; Yun‐Yun Wei; Xue‐Ming Zhu; Jian‐Ping Lu; Fu‐Cheng Lin; Xiao‐Hong Liu (Environmental Microbiology, 2022)
Summary Magnaporthe oryzae is an important plant pathogen that causes rice blast. Hse1 and Vps27 are components of ESCRT‐0 involved in the multivesicular body (MVB) sorting pathway and biogenesis. To date, the biological functions of ESCRT‐0 in M. oryzae have not been determined. In this study, we identified and characterized Hse1 and Vps27 in M. oryzae . Disruption of MoHse1 and MoVps27 caused pleiotropic defects in growth, conidiation, sexual development and pathogenicity, thereby resulting in loss of virulence in rice and barley leaves. Disruption of MoHse1 and MoVps27 triggered increased lipidation of MoAtg8 and degradation of GFP‐MoAtg8, indicating that ESCRT‐0 is involved in the regulation of autophagy. ESCRT‐0 was determined to interact with coat protein complex II (COPII), a regulator functioning in homeostasis of the endoplasmic reticulum (ER homeostasis), and disruption of MoHse1 and MoVps27 also blocked activation of the unfolded protein response (UPR) and autophagy of the endoplasmic reticulum (ER‐phagy). Overall, our results indicate that ESCRT‐0 plays critical roles in regulating fungal development, virulence, autophagy and ER‐phagy in M. oryzae .

Prevalence, complete genome, and metabolic potentials of a phylogenetically novel cyanobacterial symbiont in the coral‐killing sponge, Terpios hoshinota - Yu‐Hsiang Chen; Hsing‐Ju Chen; Cheng‐Yu Yang; Jia‐Ho Shiu; Daphne Z. Hoh; Pei‐Wen Chiang; Wenhua Savanna Chow; Chaolun Allen Chen; Tin‐Han Shih; Szu‐Hsien Lin; Chi‐Ming Yang; James Davis Reimer; et al. (Environmental Microbiology, 2022)
Summary Terpios hoshinota is an aggressive, space‐competing sponge that kills various stony corals. Outbreaks of this species have led to intense damage to coral reefs in many locations. Here, the first large‐scale 16S rRNA gene survey across three oceans revealed that bacteria related to the taxa Prochloron , Endozoicomonas , SAR116, Ruegeria , and unclassified Proteobacteria were prevalent in T . hoshinota . A Prochloron ‐related bacterium was the most dominant and prevalent cyanobacterium in T . hoshinota . The complete genome of this uncultivated cyanobacterium and pigment analysis demonstrated that it has phycobiliproteins and lacks chlorophyll b , which is inconsistent with the definition of Prochloron . Furthermore, the cyanobacterium was phylogenetically distinct from Prochloron , strongly suggesting that it should be a sister taxon to Prochloron . Therefore, we proposed this symbiotic cyanobacterium as a novel species under the new genus Candidatus Paraprochloron terpiosi. Comparative genomic analyses revealed that ‘Paraprochloron’ and Prochloron exhibit distinct genomic features and DNA replication machinery. We also characterized the metabolic potentials of ‘Paraprochloron terpiosi’ in carbon and nitrogen cycling and propose a model for interactions between it and T. hoshinota . This study builds a foundation for the study of the T . hoshinota microbiome and paves the way for better understanding of ecosystems involving this coral‐killing sponge.

Effects of Suspended Particles on Exopolysaccharide Secretion of Two Microalgae in Jinjiang Estuary (Fujian, China) - Jie Liu; Xiaoyu Han; Hui Xing; Yiting Nan; Jiahui Lin; Junming He; Sijia Chen; Yanfang Wei; Peiyong Guo (Journal of Marine Science and Engineering, 2022)
The effects of suspended particles (SP) of different concentrations and sizes on the secretion of exopolysaccharide (EPS) by Chlorella pyrenoidosa (C. pyrenoidosa) and Microcystis flos-aquae (M. flos-aquae) in Jinjiang Estuary, Fujian Province, China were studied in co-cultures of microalgae and SP. The results show that the SP concentration has an “inhibit–promote–inhibit” effect on the secretion of EPS by C. pyrenoidosa, whereby there is an optimal concentration of SP corresponding to the largest amount of EPS secreted by C. pyrenoidosa. Low concentrations had no significant effect on the secretion of EPS from M. flos-aquae (p > 0.05), whereas higher concentrations had an inhibitory effect. The C. pyrenoidosa EPS content was found to be significantly decreased in response to SP of small particle sizes (0–75 and 75–120 μm) and significantly increased for SP of large particle sizes (120–150 and 150–500 μm). Small particle sizes (0–75 and 75–120 μm) were found to be beneficial to the secretion of EPS from M. flos-aquae, and the promotion of EPS secretion gradually decreased with the increase in SP particle size. However, when the particle size was too large (120–150 and 150–500 μm), SP had no significant effect on EPS secretion. This study is helpful for understanding the microalgae EPS secretion response to SP and provides a scientific basis for studying the mechanism of EPS secretion by algae and the effect of SP on eutrophication of the estuary.

Characteristics of typical air pollutants in a valley-basin city in South China - Chu Wu; Jibing Li; Xiaoping Lin; Yangzhi Mo; Hui Zhang; Zhihui Liao; Yu Wang; Duohong Chen (Meteorology and Atmospheric Physics, 2022)

Identification and bioinformatics analysis of differentially expressed milk exosomal microRNAs in milk exosomes of heat-stressed Holstein cows - Yue Wang; Jian Fang; Han-Fang Zeng; Ji-Feng Zhong; Hui-Xia Li; Kun-Lin Chen (Functional & Integrative Genomics, 2022)

Functional characterization of melanocortin-3 receptor in rainbow trout (Oncorhynchus mykiss) - Hui-Xia Yu; Yang Li; Wei-Jia Song; Hui Wang; Hao-Lin Mo; Qiao Liu; Xin-Miao Zhang; Ze-Bin Jiang; Li-Xin Wang (Fish Physiology and Biochemistry, 2022)

Changes in the growth performance, antioxidant enzymes and stress resistance caused by dietary administration of synbiotic (fructooligosaccharide and probiotics) in juvenile Chinese Mitten Crab, Eriocheir sinensis - Jin-Juan Wan; Jian-lin Pan; Mei-Fang Shen; Hui Xue; Meng-lin Sun; Mei-Qin Zhang; Xi-He Zhu; Xing-kong Ma (Aquaculture International, 2022)

Climate warming promotes deterministic assembly of arbuscular mycorrhizal fungal communities - Xinyu Xu; Yunpeng Qiu; Kangcheng Zhang; Fei Yang; Mengfei Chen; Xi Luo; Xuebin Yan; Peng Wang; Yi Zhang; Huaihai Chen; Hui Guo; Lin Jiang; et al. (Global Change Biology, 2022)
Arbuscular mycorrhizal fungi (AMF) significantly contribute to plant resource acquisition and play important roles in mediating plant interactions and soil carbon (C) dynamics. However, it remains unclear how AMF communities respond to climate change. We assessed impacts of warming and precipitation alterations (30% increase or decrease) on soil AMF communities, and examined major ecological processes shaping the AMF community assemblage in a Tibetan alpine meadow. Our results showed that warming significantly increased root biomass, and available nitrogen (N) and phosphorus (P) in soil. While precipitation alterations increased AMF abundances, they did not significantly affect the composition or diversity of AMF communities. In contrast, warming altered the composition of AMF communities and reduced their Shannon–Wiener index and Pielou's evenness. In particular, warming shifted the AMF community composition in favor of Diversisporaceae over Glomeraceae, likely through its impact on soil N and P availability. In addition, AMF communities were phylogenetically random in the unwarmed control but clustered in warming plots, implying more deterministic community assembly under climate warming. Warming enhancement of root growth, N and P availability likely reduced plant C‐allocation to AMF, imposing stronger environmental filtering on AMF communities. We further proposed a conceptual framework that integrates biological and geochemical processes into a mechanistic understanding of warming and precipitation changes’ effects on AMF. Taken together, these results suggest that soil AMF communities may be more sensitive to warming than expected, highlighting the need to monitor their community structure and associated functional consequences on plant communities and soil C dynamics under the future warmer climate.

Molecular Identification of Species Diversity Using Pelagic Fish Eggs in Spring and Late Autumn-Winter in the Eastern Beibu Gulf, China - Gang Hou; Yanying Chen; Jinrun Wang; Chuanhao Pan; Jianbin Lin; Bo Feng; Hui Zhang (Frontiers in Marine Science, 2022)
The Beibu Gulf is considered as one of China’s four major fishing grounds, although the substantial overexploitation of fisheries has led to the collapse of many fish stocks, and to changes to spawning grounds in recent decades. Classifying fish eggs is an important way to monitor the recruitment process and identify the spawning sites of fish. However, the lack of a basis for morphological identification and difficulties in correctly identifying fish eggs based on morphological characteristics has limited scientific studies. In the present study, we identified fish eggs using molecular detection of cytochrome c oxidase subunit I and cytochrome b fragments. Ichthyoplankton surveys were conducted in the spring and late autumn–winter of 2020 in the eastern Beibu Gulf. Among the DNA extracted from the 873 chosen fish eggs, we successfully obtained 541 high-quality cytochrome c oxidase subunit I sequences and 41 high-quality cytochrome b sequences. We successfully identified 212 fish eggs (36.4%) from 32 species; 291 eggs (50.0%) showed ambiguous species delimitation, and 79 eggs (13.6%) could not be identified. Among the identified species, we found 25 species in spring and 25 species in late autumn–winter, out of which 18 species occurred in both seasons. We also obtained high resolution photographs of fish eggs at the species level for further morphological analysis and identification. The present study confirms the efficacy of using molecular methods to identify fish species from eggs and provides valuable information for protecting the spawning ground of economically valuable fish and for managing fishery resources.

Characterization of alkaloids in radix Sophora tonkinensis by UPLC-Q-TOF-MS/MS and its application in the comparison of two different habitats - Xing-Xing Zong; Yu Wang; Jia-Liang Xiong; Yu-Hui Ping; Qiong-Lin Liang (Natural Product Research, 2022)

Distinct durability of IgM/IgG antibody responses in COVID-19 patients with differing severity - Junyan Han; Ning Zhang; Danying Chen; Yuhuan Gong; Guoli Li; Yaxian Kong; Lin Pu; Chen Chen; Jingyuan Liu; Qi Wang; Ju Zhang; Xuesen Zhao; et al. (Science China Life Sciences, 2022)

Phylogeographic pattern of a cryptoviviparous mangrove, Aegiceras corniculatum, in the Indo-West Pacific, provides insights for conservation actions - Achyut Kumar Banerjee; Hui Feng; Yuting Lin; Zhuangwei Hou; Weixi Li; Huiyu Shao; Zida Luo; Wuxia Guo; Yelin Huang (Planta, 2022)

β-Catenin Deletion in Regional Neural Progenitors Leads to Congenital Hydrocephalus in Mice - Lin Ma; Yanhua Du; Xiangjie Xu; Hexi Feng; Yi Hui; Nan Li; Guanyu Jiang; Xiaoqing Zhang; Xiaocui Li; Ling Liu (Neuroscience Bulletin, 2022)

Identification of Novel Nonapeptides from Sipunculus nudus L. and Comparing Its ACEI Activities Mechanism by Molecular Docking - Yi Qi; Xiaoning Tang; Huan Liu; Qianxing Lin; Yingnian Lu; Hui Luo (International Journal of Peptide Research and Therapeutics, 2022)

The difference in the intracellular Arg/Lys-rich and EHLVY motifs contributes to distinct subcellular distribution of HAI-1 versus HAI-2 - Nanxi Huang; Robert B. Barndt; Dajun D. Lu; Qiaochu Wang; Shih-Ming Huang; Jehng-Kang Wang; Ping-Ying Chang; Chao-Yang Chen; Je-Ming Hu; Hui-Chen Su; Michael D. Johnson; Chen-Yong Lin (Human Cell, 2022)

Regulatory role of miR-129 and miR-384-5p on apoptosis induced by oxygen and glucose deprivation in PC12 cell - Hui-Lin Guan; Yue Guan; Wen-Yuan Li; Jia-Wei Liu; Yu-Jia Zheng; Yan-Zhong Guan; Hong-Feng Liu; Li-Xin Guan; Feng-Guo Zhai (Experimental Brain Research, 2022)

N-acetylcysteine alleviates pulmonary inflammatory response during benzo[a]pyrene-evoked acute lung injury - Hui Zhao; Lin Fu; Hui-Xian Xiang; Ying Xiang; Meng-Die Li; Bian-Bian Lv; Zhu-Xia Tan; Lan Gao; Cheng Zhang; De-Xiang Xu (Environmental Science and Pollution Research, 2022)

Sabulicella rubraurantiaca gen. nov., sp. nov., a new member of the family Acetobacteraceae, isolated from desert soil - Zhi-Liang Lin; Shuai Li; Qi-Chuang Wei; Wen-Hui Lian; Chun-Yan Lu; Lu Xu; Li-Nan Huang; Lei Dong; Wen-Jun Li (Archives of Microbiology, 2022)

Temporal and spatial distribution characteristics of nutrients in Clarion-Clipperton Fracture Zone in the Pacific in 2017 - Baohong Chen; Kaiwen Zhou; Kang Wang; Jigang Wang; Sumin Wang; Xiuwu Sun; Jinmin Chen; Cai Lin; Hui Lin (Acta Oceanologica Sinica, 2022)

Mycorrhizal associations of tree species influence soil nitrogen dynamics via effects on soil acid–base chemistry - Guigang Lin; Matthew E. Craig; Insu Jo; Xugao Wang; De‐Hui Zeng; Richard P. Phillips (Global Ecology and Biogeography, 2022)
Aim Plants and their associated microbes influence nutrient cycling in terrestrial ecosystems, yet we have a limited understanding of how soil acidity mediates the process. Here, we investigate whether reported differences in nitrogen (N) cycling between forests dominated by arbuscular mycorrhizal (AM) trees and ectomycorrhizal (ECM) trees are related to changes in soil acid–base chemistry induced by mycorrhizal associations. Location Global. Time period 1969–2018. Major taxa studied Trees. Methods We measured and synthesized variables of leaf litter quality, soil acid–base chemistry and N cycling from: (1) a landscape‐scale study of 230 subplots varying widely in AM tree dominance in a 25 ha forest plot; (2) a regional‐scale study of 40 AM‐ and 56 ECM‐dominated plots in 10 temperate forests across the eastern USA; (3) a continental‐scale study of > 3,000 forest plots from 10 ecoregions across the contiguous USA; and (4) a global meta‐analysis of 105 study sites with co‐occurring AM and ECM forest stands. Results Across all spatial scales, ECM‐dominated forests were associated with greater soil acidity. In particular, ECM‐dominated soils exhibited lower soil pH and base cations, although the magnitude of mycorrhizal‐associated differences in soil acid–base chemistry depended on the biomes, with differences being more pronounced in temperate than in sub/tropical forests. Higher lignin and lower base cations in ECM tree leaf litter were related to greater soil acidity in ECM‐dominated forests. Moreover, the lower inorganic N concentrations and slower N transformation rates in ECM‐dominated forests were associated with their greater soil acidity. Main conclusions Our results indicate that the scale‐invariant feedbacks between plant nutrient‐use strategies and soil properties have the potential to impact forest community assembly and ecosystem processes, particularly in the context of global change.

210Pb-Derived Bioturbation Rates in Sediments Around Seamounts in the Tropical Northwest Pacific - Feng Lin; Cai Lin; Hui Lin; Xiuwu Sun; Li Lin (Frontiers in Marine Science, 2021)
To evaluate bioturbation coefficients (D B ) and mixing depths (L), 210 Pb and 226 Ra activity was measured in two sediments cores (from water depths of 5,398 m and 4,428 m), which were collected from seamount areas in the Northwest Pacific. Using a steady-state diffusion mode, we estimated D B values of 16.8 and 24.1 cm 2 /a, higher than those in abyssal sediments and those predicted by traditional empirical equations. Corresponding L values varied between 19.3 and 23.1 cm. These high values indicate that seamounts are the area of active bioturbation. A one-dimensional model for the transport of total organic carbon (TOC) from the surface layer of sediments to the deep layer was developed using the distribution pattern of the specific activity of excess 210 Pb ( 210 Pb ex ) and its relationship with TOC. The model showed that the TOC flux transmitted downward by bioturbation was 0.09 mmol/(cm 2 ⋅a) and 0.12 mmol/(cm 2 ⋅a).

Observations of Suspended Particulate Matter Concentrations and Particle Size Distributions within a Macrotidal Estuary (Port Curtis Estuary, Australia) - Ryan J. K. Dunn; Jordan Glen; Hsin-Hui Lin; Sasha Zigic (Journal of Marine Science and Engineering, 2021)
An understanding of suspended particulate matter (SPM) dynamics is of great importance to design awareness and management strategies of estuaries. Using a Laser In Situ Scattering and Transmissiometry (LISST) instrument, variations in suspended particle size volumetric concentrations (VC) and particle size distributions (PSD) were measured at six sites within Port Curtis estuary (Australia). The port is a macrotidal estuary with significant economic and environmental importance. Observed VC and SPM sizes demonstrated spatial and temporal trends strongly controlled by the variable energy conditions operating on the neap and spring cycle timescale, with a clear trend towards increasing concentrations and decreasing SPM sizes with increasing tidal ranges. Mid-estuary sites were characterized by the greatest depth-averaged VC under transitional and spring conditions. Estuary-wide mean spring tide total water profile concentrations revealed a near 300% increase in comparison to neap tide condition concentrations. In the upper-estuary sites the mean contribution of the combined 2.5–35 µm size classes to the total profile PSDs was greatest during all tidal conditions, whilst within the lower-estuary site the combined 35–130 µm size classes were greatest. Mean contributions of the largest size class (300–500 µm) dominated surface-waters throughout the estuary during the neap tide period, which when compared with the transitional and spring tide conditions, demonstrated changes of −82% to −48% and −82% to −40%, respectively. Overall, the results from this case study provides further evidence of the important influence of neap and spring tidal regimes on SPM dynamics within estuarine settings and the need to observe parameter dynamics on such timescales.

Immuno-modulatory effects of macluraxanthone on macrophage phenotype and function - Ida May Jen Ng; Siau Hui Mah; Caroline Lin Lin Chua (Natural Product Research, 2021)

210Po-210Pb Disequilibrium in the Western North Pacific Ocean: Particle Cycling and POC Export - Qiangqiang Zhong; Tao Yu; Hui Lin; Jing Lin; Jianda Ji; Jialin Ni; Jinzhou Du; Dekun Huang (Frontiers in Marine Science, 2021)
Estimating the particulate organic carbon (POC) export flux from the upper ocean is fundamental for understanding the efficiency of the biological carbon pump driven by sinking particles in the oceans. The downward POC flux from the surface ocean based on 210 Po- 210 Pb disequilibria in seawater samples from the western North Pacific Ocean (w-NPO) was measured in the early summer (May-June) of 2018. All the profiles showed a large 210 Po deficiency relative to 210 Pb in the euphotic zone (0–150 m), while this 210 Po deficiency vanished below ∼500 m (with 210 Po/ 210 Pb ∼1 or > 1). A one-dimensional steady-state irreversible scavenging model was used to quantify the scavenging and removal fluxes of 210 Po and 210 Pb in the euphotic zone of the w-NPO. In the upper ocean (0–150 m), dissolved 210 Po (D-Po) was scavenged into particles with a residence time of 0.6–5.5 year, and the 210 Po export flux out of the euphotic zone was estimated as (0.33–3.49) × 10 4 dpm/m 2 /year, resulting in a wide range of particulate 210 Po (P-Po) residence times (83–921 days). However, in the deep ocean (150–1,000 m), 210 Po was transferred from the particulate phase to the dissolved phase. Using an integrated POC inventory and the P-Po residence times (Eppley model) in the w-NPO euphotic zone, the POC export fluxes (mmol C/m 2 /d) varied from 0.6 ± 0.2 to 8.8 ± 0.4. In comparison, applying the POC/ 210 Po ratio of all (>0.45 μm) particles to 210 Po export flux (Buesseler model), the obtained POC export fluxes (mmol C/m 2 /d) ranged from 0.7 ± 0.1 to 8.6 ± 0.8. Both Buesseler and Eppley methods showed enhanced POC export fluxes at stations near the continental shelf (i.e., Luzon Strait and the Oyashio-Kuroshio mixing region). The Eppley model-based 210 Po-derived POC fluxes agreed well with the Buesseler model-based fluxes, indicating that both models are suitable for assessing POC fluxes in the w-NPO. The POC export efficiency was < 15%, suggesting a moderate biological carbon pump efficiency in the w-NPO. These low export efficiencies may be associated with the dominance of smaller particles and the processes of degradation and subsequent remineralization of these small particles in the euphotic zone of oligotrophic regions in the w-NPO.

The Key Regulator of Necroptosis, RIP1 Kinase, Contributes to the Formation of Astrogliosis and Glial Scar in Ischemic Stroke - Yong-Ming Zhu; Liang Lin; Chao Wei; Yi Guo; Yuan Qin; Zhong-Sheng Li; Thomas A. Kent; Claire E. McCoy; Zhan-Xiang Wang; Yong Ni; Xian-Yong Zhou; Hui-Ling Zhang (Translational Stroke Research, 2021)
Necroptosis initiation relies on the receptor-interacting protein 1 kinase (RIP1K). We recently reported that genetic and pharmacological inhibition of RIP1K produces protection against ischemic stroke-induced astrocytic injury. However, the role of RIP1K in ischemic stroke-induced formation of astrogliosis and glial scar remains unknown. Here, in a transient middle cerebral artery occlusion (tMCAO) rat model and an oxygen and glucose deprivation and reoxygenation (OGD/Re)-induced astrocytic injury model, we show that RIP1K was significantly elevated in the reactive astrocytes. Knockdown of RIP1K or delayed administration of RIP1K inhibitor Nec-1 down-regulated the glial scar markers, improved ischemic stroke-induced necrotic morphology and neurologic deficits, and reduced the volume of brain atrophy. Moreover, knockdown of RIP1K attenuated astrocytic cell death and proliferation and promoted neuronal axonal generation in a neuron and astrocyte co-culture system. Both vascular endothelial growth factor D (VEGF-D) and its receptor VEGFR-3 were elevated in the reactive astrocytes; simultaneously, VEGF-D was increased in the medium of astrocytes exposed to OGD/Re. Knockdown of RIP1K down-regulated VEGF-D gene and protein levels in the reactive astrocytes. Treatment with 400 ng/ml recombinant VEGF-D induced the formation of glial scar; conversely, the inhibitor of VEGFR-3 suppressed OGD/Re-induced glial scar formation. RIP3K and MLKL may be involved in glial scar formation. Taken together, these results suggest that RIP1K participates in the formation of astrogliosis and glial scar via impairment of normal astrocyte responses and enhancing the astrocytic VEGF-D/VEGFR-3 signaling pathways. Inhibition of RIP1K promotes the brain functional recovery partially via suppressing the formation of astrogliosis and glial scar. Graphical Abstract

Molecular characterization and gene expression analysis of tomato WOX transcription factor family under abiotic stress and phytohormone treatment - Hui Li; Xiaohong Li; Meihua Sun; Shuisen Chen; Hui Ma; Jingwei Lin; Yibo Sun; Ming Zhong (Journal of Plant Biochemistry and Biotechnology, 2021)

Efficacy and safety between early use and late use of celecoxib in hip osteoarthritis patients who receive total hip arthroplasty: a randomized, controlled study - Chunxue Pu; Xue Jiang; Yuanxin Sun; Hui Lin; Shaochen Li (Inflammopharmacology, 2021)

Predicting circRNA-Disease Associations Based on Deep Matrix Factorization with Multi-source Fusion - Guobo Xie; Hui Chen; Yuping Sun; Guosheng Gu; Zhiyi Lin; Weiming Wang; Jianming Li (Interdisciplinary Sciences: Computational Life Sciences, 2021)

Feasibility and utility of facemask sampling in the detection of SARS-CoV-2 during an ongoing pandemic - Dorothy Hui Lin Ng; Mei Yi Sim; Hong Hong Huang; Jean Xiang Ying Sim; Jenny Guek Hong Low; Jay Kheng Sit Lim (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Occurrence, source apportionment, and carcinogenic risk assessment of polycyclic aromatic hydrocarbons in urban road dusts in Shanghai - Xue-Tong Wang; Rui Fu; Ying Zhou; Cheng-Lin Wang; Guo-Fa Ren; Xiao-Li Wang; Hui Li (Environmental Science and Pollution Research, 2021)

Driving forces for recovery of forest vegetation after harvesting a subalpine oak forest in eastern Tibetan Plateau - Qinli Xiong; Lingjuan Li; Xiaojin Luo; Xingjin He; Lin Zhang; Kaiwen Pan; Chenggang Liu; Hui Sun (Environmental Science and Pollution Research, 2021)

Dinoflagellate-targeted PCR reveals highly abundant and diverse communities of parasitic dinoflagellates in and near Zhubi Reef, South China Sea - Dajun Qiu; Liangmin Huang; Yunyun Zhuang; Yu Zhong; Yuehui Tan; Xiubao Li; Sheng Liu; Hui Huang; Senjie Lin (Coral Reefs, 2021)

Generation and characterization of a Myh6-driven Cre knockin mouse line - Xinyan Huang; Lei Yan; Shan Kou; Jufeng Meng; Zhengkai Lu; Chao-Po Lin; Chen Liu; Hui Zhang (Transgenic Research, 2021)
Gene deletion by the Cre-Loxp system has facilitated functional studies of many critical genes in mice, offering important insights and allowing deeper understanding on the mechanisms underlying organ development and diseases, such as heart development and diseases. In this study, we generated a Myh6-Cre knockin mouse model by inserting the IRES-Cre-wpre-polyA cassette between the translational stop codon and the 3′ untranslated region of the endogenous Myh6 gene. By crossing knockin mice with the Rosa26 reporter lines, we found that Myh6-Cre targeted cardiomyocytes at the embryonic and postnatal stages. In addition, we were able to inactivate the desmosome gene Desmoplakin (Dsp) by breeding Myh6-Cre mice with a conditional Dsp flox knockout mouse line, which resulted in embryonic lethality during the mid-term pregnancy. These results suggest that the new Myh6-Cre mouse line can serve as a robust tool to dissect the distinct roles of genes involved in heart development and function.

Microplastics in Mollusks: Research Progress, Current Contamination Status, Analysis Approaches, and Future Perspectives - Ruixuan Wang; Hongli Mou; Xiaozhi Lin; Hui Zhu; Bing Li; Jiangyong Wang; Muhammad Junaid; Jun Wang (Frontiers in Marine Science, 2021)
Plastic fragments < 5 mm, known as microplastics (MPs), are ubiquitously present in the marine environment. Research on MPs pollution has gradually shifted from field investigations to laboratory studies. With the rapid growth of plastic consumption and the prevalence of aquaculture products, studies on marine MPs have focused on key marine species, such as mollusks. This review summarizes the recent knowledge including 77 important relevant literatures (from 2010 to 2021) on MPs contamination in mollusks with the objectives of (1) elucidating the current status of MPs pollution levels in mollusks, (2) highlighting the main methods and techniques for separation, extraction, and identification of MPs in soft tissues of bivalves and (3) presenting the current research progress and future directions. The review visually presents some of the important results in graphic form, which shows that the most common polymer plastics in bivalves are polypropylene, polystyrene, and polyethylene, and the shapes were mainly fiber and threadiness, mollusks are more likely to feed smaller MPs, most of the MPs in bivalves are less than 500 μm, and the abundance of MPs in seawater and the abundance of MPs in mollusks have a positive relationship, etc. This review will provide a comprehensive reference for studies of microplastics in marine organisms and the ecological pollution, and also has scientific guiding significance in the research method.

Phenolic glycosides and flavonoids with antioxidant and anticancer activities from Desmodium caudatum - Qian-Nan Xu; Dan Zhu; Guang-Hui Wang; Ting Lin; Cui-Ling Sun; Rong Ding; Wen-Jing Tian; Hai-Feng Chen (Natural Product Research, 2021)

Effect of heat stress on oxidative damage and antioxidant defense system in white clover (Trifolium repens L.) - Hsiang-Lin Liu; Zhu-Xuan Lee; Tzu-Wei Chuang; Hui-Chen Wu (Planta, 2021)

Does regional planning policy of Yangtze River Delta improve green technology innovation? Evidence from a quasi-natural experiment in China - Hong Xu; Lei Qiu; Baozhen Liu; Bei Liu; Hui Wang; Weifen Lin (Environmental Science and Pollution Research, 2021)

Streptococcus vaginalis sp. nov., a novel bacterial species isolated from vaginal swabs of a pregnant woman with diabetes - An-Shine Chao; Chiao-Yun Lin; Angel Chao; Yun-Shien Lee; Yu-Chung Chang; Hui-Chung Wu; Yu-Jie Dai; Wei-Qi Liao; Fan-Ching Kao; Yi-Sheng Chen (Archives of Microbiology, 2021)

A new abietane diterpene and anti-complementary constituents from Juniperus tibetica - Dong-Lin Zeng; Chang-Yue Wang; Hui-Qin Gao; Dao-Feng Chen; Yan Lu (Natural Product Research, 2021)

Two new cephalochromin derivative from the Alternaria sp. ZG22 - Xin-Ming Song; Xue-Ming Zhou; Ya-Ling Li; Li-Bing Huang; Cai-Cui Chen; Yan Gao; Lin He; Xiao-qun Mao; Bing Chen; Jing-Wen Liu; Hui-Jie Liu; Xiao-Ping Song; et al. (Natural Product Research, 2021)

Functional analysis of indole 3-hexanoic acid as a novel auxin from Arabidopsis thaliana - Ping Song; Hui Xu; Jixiu Zhang; Huatao Chen; Li Li; Yana Qu; Feng Lin; Qun Zhang (Planta, 2021)

How do different nitrogen application levels and irrigation practices impact biological nitrogen fixation and its distribution in paddy system? - Yanhui Zhang; Tianlong Hu; Hui Wang; Haiyang Jin; Qi Liu; Zhibin Lin; Benjuan Liu; Hongtao Liu; Zhe Chen; Xinwu Lin; Xiaojie Wang; Jing Ma; et al. (Plant and Soil, 2021)

Comparing the clinical outcomes across different sodium/glucose cotransporter 2 (SGLT2) inhibitors in heart failure patients: a systematic review and network meta-analysis of randomized controlled trials - Yao Hao Teo; Celine Shuen Yin Yoong; Nicholas L. Syn; Yao Neng Teo; Jia Yang Alex Cheong; Yoke-Ching Lim; Chi-Hang Lee; Tiong-Cheng Yeo; Ping Chai; Raymond C. C. Wong; Weiqin Lin; Ching-Hui Sia (European Journal of Clinical Pharmacology, 2021)

Exercise renovates H2S and Nrf2-related antioxidant pathways to suppress apoptosis in the natural ageing process of male rat cortex - Jing-Ying Lin; Tsung-Jung Ho; Bruce Chi-Kang Tsai; Chien-Yi Chiang; Hui-Chuan Kao; Wei-Wen Kuo; Ray-Jade Chen; Vijaya Padma Viswanadha; Chi-Wen Huang; Chih-Yang Huang (Biogerontology, 2021)

Sandaracinobacteroides hominis gen. nov., sp. nov., isolated from human skin - Ping-Hua Qu; Hai-Min Luo; Jun-Hui Feng; Song Li; Cha Chen; Lei Dong; Yu-Zhen Ming; Wen-Jun Li; Ying Lin (Archives of Microbiology, 2021)

Assemblage Structure of the Ichthyoplankton and Its Relationship With Environmental Factors in Spring and Autumn off the Pearl River Estuary - Gang Hou; Jinrun Wang; Limei Liu; Yanying Chen; Chuanhao Pan; Jianbin Lin; Hui Zhang (Frontiers in Marine Science, 2021)
Ichthyoplankton assemblages and their relationship with environmental variables are investigated in waters off the Pearl River Estuary in spring and autumn of 2019. Of 80 ichthyoplankton taxa identified using DNA barcode and morphological methods, 61 are identified to species. The most abundance families (Carangidae, Trichiuridae, Mullidae, and Scombridae) account for 61.34% of the horizontal total catch in spring, while Menidae and Carangidae are the most abundant families identified in autumn, accounting for 89.72% of the horizontal total catch. Cluster analysis identifies three species assemblages in spring, and four in autumn based on horizontal trawls. Relationships between assemblage structure and environmental variables ( in situ and remote sensed) are determined by canonical correspondence analysis. Ichthyoplankton assemblage structure appears to be strongly influenced by sea level anomalies, salinity, water depth, temperature at 10 m depth, and distance from shore. We demonstrate the efficacy of using DNA barcode to identify ichthyoplankton, and suggest how these data can be used to protect fish spawning grounds in waters off the Pearl River Estuary.

Experimental study on integrated and autonomous conductivity-temperature-depth (CTD) sensor applied for underwater glider - Bin Lv; Hai-lin Liu; Yi-fan Hu; Cheng-xuan Wu; Jie Liu; Hai-jing He; Jie Chen; Jian Yuan; Zhao-wen Zhang; Lin Cao; Hui Li (Marine Georesources & Geotechnology, 2021)

Human Amniotic Epithelial Cells Alleviate a Mouse Model of Parkinson’s Disease Mainly by Neuroprotective, Anti-Oxidative and Anti-Inflammatory Factors - Jiaofei Zhang; Hui Li; Hao Yang; Jianhua Lin; You Wang; Qianjun Zhang; Wei-Qiang Gao; Huiming Xu (Journal of Neuroimmune Pharmacology, 2021)

Identification of a major QTL related to resistance to soybean mosaic virus in diverse soybean genetic populations - Jiahao Chu; Wenlong Li; Dongri Piao; Feng Lin; Xiaobo Huo; Hua Zhang; Hui Du; Youbin Kong; Yuan Jin; Xihuan Li; Caiying Zhang (Euphytica, 2021)

Protective effect of Bombyx mori gloverin on intestinal epithelial cells exposure to enterotoxigenic E. coli - Qian Lin; Qingqing Fu; Guoqi Su; Daiwen Chen; Bing Yu; Yuheng Luo; Ping Zheng; Xiangbing Mao; Zhiqing Huang; Jie Yu; Junqiu Luo; Hui Yan; et al. (Brazilian Journal of Microbiology, 2021)

Application of the modified cytosine base-editing in the cultured cells of bama minipig - Jia-sheng Pan; Zi-sheng Lin; Jian-cong Wen; Jian-feng Guo; Xia-hui Wu; Ying-ying Liu; Wen-jun Lai; Qi-ying Liang; Yong-shi Xie; Yi-rou Chen; Yi-hong Chen; Ai-fen Yan; et al. (Biotechnology Letters, 2021)

3D Step-by-step inversion strategy for audio magnetotellurics data based on unstructured mesh - San Cheng; Zhi-Yong Zhang; Feng Zhou; Man Li; Hui Chen; Fu-Sheng Shi; Lin-Pin Huang; Yong Li (Applied Geophysics, 2021)

Taxonomic description of Pseudomonas rhizovicinus sp. nov., isolated from the rhizosphere of a desert shrub Haloxylon ammodendron - Ao-Lei He; Hui-Ru Li; Hui-Ping Li; Jing-Yi Gou; Jia Chen; Qi Zhao; Jin-Lin Zhang (Antonie van Leeuwenhoek, 2021)

The Significant Role of Radiosonde-measured Cloud-base Height in the Estimation of Cloud Radiative Forcing - Hui Xu; Jianping Guo; Jian Li; Lin Liu; Tianmeng Chen; Xiaoran Guo; Yanmin Lyu; Ding Wang; Yi Han; Qi Chen; Yong Zhang (Advances in Atmospheric Sciences, 2021)

Stock Assessment of 19 Perciformes in the Beibu Gulf, China, Using a Length-Based Bayesian Biomass Method - Gang Hou; Hui Zhang; Jinrun Wang; Yanying Chen; Jianbin Lin (Frontiers in Marine Science, 2021)
The Beibu Gulf in China is rich in fish resources. However, only a small number of commercially developed fish stocks have been specifically assessed owing to limited data and expertise. In this study, 19 perciform fish populations in the Beibu Gulf were assessed using a length-based Bayesian biomass (LBB) estimator method, which is a new approach to evaluate a fishery’s status using length frequency (LF) data. The results showed that only 21% of the evaluated stocks were healthy and 79% were overfished. In particular, 26 and 21% of the assessed species had collapsed and were grossly overfished, respectively. Only 11 and 21% of the assessed species were slightly overfished and overfished, respectively. The ratios between the mean and optimum length ( L mean /L opt ) and between the mean length at first capture and the mean length, which maximizes catch and biomass ( L c /L c_opt ), were below one in 14 out of the 19 stocks, suggesting a truncated length structure and fishing of undersized individuals. The ratio of the 95th percentile length to asymptotic length L 95th /L inf was close to one (>0.9) in 10 of 19 stocks, suggesting that at least some large fish were still present. Our research confirmed that the fishery resources in the Beibu Gulf were seriously overfished and provided evidence that LBB was an efficient method to evaluate the fishery resources. Fishery managers need to take specific measures to restore fishery resources.

Optimization of ultrasound and microwave-assisted extraction of sweet cherry tree branches and chemical component analysis by UPLC–MS/MS - Huimin Zhang; Hongguang Yan; Cuixiang Lu; Hui Lin; Quan Li (Trees, 2021)

Geographic modeling and simulation systems for geographic research in the new era: Some thoughts on their development and construction - Min Chen; Guonian Lv; Chenghu Zhou; Hui Lin; Zaiyang Ma; Songshan Yue; Yongning Wen; Fengyuan Zhang; Jin Wang; Zhiyi Zhu; Kai Xu; Yuanqing He (Science China Earth Sciences, 2021)
Regionality, comprehensiveness, and complexity are regarded as the basic characteristics of geography. The exploration of their core connotations is an essential way to achieve breakthroughs in geography in the new era. This paper focuses on the important method in geographic research: Geographic modeling and simulation. First, we clarify the research requirements of the said three characteristics of geography and its potential to address geo-problems in the new era. Then, the supporting capabilities of the existing geographic modeling and simulation systems for geographic research are summarized from three perspectives: Model resources, modeling processes, and operational architecture. Finally, we discern avenues for future research of geographic modeling and simulation systems for the study of regional, comprehensive and complex characteristics of geography. Based on these analyses, we propose implementation architecture of geographic modeling and simulation systems and discuss the module composition and functional realization, which could provide theoretical and technical support for geographic modeling and simulation systems to better serve the development of geography in the new era.

Possible pharmaceutical applications can be developed from naturally occurring phenanthroindolizidine and phenanthroquinolizidine alkaloids - Xian-hui Jia; Huan-xin Zhao; Cheng-lin Du; Wen-zhao Tang; Xiao-jing Wang (Phytochemistry Reviews, 2021)

Prediction of Metabolic Disorders Using NMR-Based Metabolomics: The Shanghai Changfeng Study - Qi Wu; Qing-xia Huang; Hai-luan Zeng; Shuai Ma; Huan-dong Lin; Ming-feng Xia; Hui-ru Tang; Xin Gao (Phenomics, 2021)

Associations of Sleep Characteristics with Cerebrospinal Fluid sTREM2 in Cognitively Normal Older Adults: the CABLE Study - He-Ying Hu; Ling-Zhi Ma; Hao Hu; Yan-Lin Bi; Ya-Hui Ma; Xue-Ning Shen; Ya-Nan Ou; Qiang Dong; Lan Tan; Jin-Tai Yu (Neurotoxicity Research, 2021)

Genipin Attenuates Tau Phosphorylation and Aβ Levels in Cellular Models of Alzheimer’s Disease - Meiting Li; Nan Cai; Liang Gu; Lijun Yao; Decheng Bi; Weishan Fang; Zhijian Lin; Yan Wu; Hong Xu; Hui Li; Zhangli Hu; Xu Xu (Molecular Neurobiology, 2021)

Upregulated SOCC and IP3R calcium channels and subsequent elevated cytoplasmic calcium signaling promote nonalcoholic fatty liver disease by inhibiting autophagy - Lin Zhang; Yifan Zhang; Yuanqing Jiang; Xiaobing Dou; Songtao Li; Hui Chai; Qianyu Qian; Miaojuan Wang (Molecular and Cellular Biochemistry, 2021)

Abnormal brain activity patterns during spatial working memory task in patients with end-stage renal disease on maintenance hemodialysis: a fMRI study - Jinzhuang Huang; Lei Xie; Ruiwei Guo; Jinhong Wang; Jinquan Lin; Zongbo Sun; Shouxing Duan; Zhirong Lin; Hui Li; Shuhua Ma (Brain Imaging and Behavior, 2021)
Hemodialysis (HD) is associated with cognitive impairment in patients with end-stage renal disease (ESRD). However, the neural mechanism of spatial working memory (SWM) impairment in HD-ESRD patients remains unclear. We investigated the abnormal alterations in SWM-associated brain activity patterns in HD-ESRD patients using blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI) technique during n-back tasks. Twenty-two HD-ESRD patients and 22 well-matched controls underwent an fMRI scan while undergoing a three-load n-back tasks with different difficulty levels. Cognitive and mental states were assessed using a battery of neuropsychologic tests. The HD-ESRD patients exhibited worse memory abilities than controls. Compared with the control group, the HD-ESRD patient group showed lower accuracy and longer response time under the n-back tasks, especially in the 2-back task. The patterns of brain activation changed under different working memory loads in the HD-ESRD patients, showing decreased activity in the right medial frontal gyrus and inferior frontal gyrus under 0-back and 1-back task, while more decreased activation in the bilateral frontal cortex, parietal lobule, anterior/posterior cingulate cortex and insula cortex under 2-back task. With the increase of task difficulty, the activation degree of the frontal and parietal cortex decreased. More importantly, we found that lower activation in frontal cortex and parietal lobule was associated with worse cognitive function in the HD-ESRD patients. These results demonstrate that the abnormal brain activity patterns of frontal cortex and parietal lobule may reflect the neural mediation of SWM impairment.

Porcine circovirus type 2 (PCV2) infection in Hebei Province from 2016 to 2019: a retrospective study - Lei Han; Guang-fu Yuan; Shao-jie Chen; Fei Dai; Lin-shan Hou; Jing-hui Fan; Yu-zhu Zuo (Archives of Virology, 2021)

Dynamic changes in size‐fractionated dissolved organic matter composition in a seasonally ice‐covered Arctic River - Hui Lin; Huacheng Xu; Yihua Cai; Claude Belzile; Robie W. Macdonald; Laodong Guo (Limnology and Oceanography, 2021)
Arctic rivers are sensitive to climate and environmental change, but the biogeochemical response remains poorly understood. Monthly size‐fractionated dissolved organic matter (DOM) samples from the lower Yukon River were characterized using UV–visible, fluorescence, and Fourier transform‐infrared (FT‐IR) spectroscopy techniques. The EEM‐PARAFAC analysis revealed three major fluorescent DOM components, including two humic‐like components (C 480 and C 400 ) and one protein‐like component (C 310 ), with their relative importance following the order of C 480 ≥ C 400 > C 310 in the high‐molecular‐weight DOM (1 kDa–0.4 μ m) and C 400 > C 480 > C 310 in the low‐molecular‐weight DOM pool ( S 275–295 ) and specific UV absorbance at 254 nm (SUVA 254 ). These changes occurred within different DOM size‐fractions and among ice‐covered, spring freshet, and open seasons. Joint analysis of EEM and FT‐IR spectra using a data fusion technique showed that humic‐like DOM is mostly associated with C─H, C═C, and C─O bonds, while protein‐like DOM is correlated more with C─N and N─H related structures. DOM aromaticity and the ratios of HIX to BIX and protein‐like to humic‐like components may be used as a compelling proxy to measure change in source waters and to infer permafrost dynamics. Our results provide insight into the seasonal variation in DOM composition for different size‐fractions in the lower Yukon River, and a baseline dataset against which future changes can be understood in the context of arctic basin biogeochemical cycling.

Disturbance-Mediated Changes in Coral Reef Habitat Provoke a Positive Feeding Response in a Major Coral Reef Detritivore, Ctenochaetus striatus - Xianzhi Lin; Simin Hu; Yong Liu; Li Zhang; Hui Huang; Sheng Liu (Frontiers in Marine Science, 2021)
Coral reefs are undergoing global phase shifts from coral-dominated to algae-dominated stages. The negative effects of this substratum shift on the diversity and abundance of fish have been well documented, but the influence on fish feeding is less studied, which may limit a deeper understanding of trophic pathways in such a disturbed system. In this study, we investigated the feeding response of a numerically dominant fish species Ctenochaetus striatus to different substrate types, including hard coral, short algal turfs (SATs, <5 mm), and long algal turfs (LATs, >5 mm), on reefs in the South China Sea. The biomass of C. striatus showed an inverted U-shaped relationship with coral coverage and a significant positive correlation with SAT coverage ( p < 0.05), indicating that rising SAT coverage associated with moderate coral loss provoked a feeding response in C. striatus . Stomach contents of C. striatus , analyzed using high-throughput sequencing (HTS), were dominated by algal sequences (relative read abundance, RRA > 80.0%), including macroalgae, filamentous algae, and microalgae (e.g., Symbiodinium and Prorocentrum ). The sequence number and diversity of microalgae (mainly dinoflagellates) tended to be abundant (RRA 13.5–36.5%) with increased SAT cover, but brown algae sequences (RRA 17.2–57.8%) or green algae sequences (RRA > 50.7% except one site) dominated the stomach content DNA in reefs with high coral cover and high LAT or macroalgal cover, respectively. Considering the limited ability of C. striatus to remove mature algae, macroalgal DNA might be from algal debris. Our results indicate that C. striatus populations respond positively to conditions of moderate coral loss through increases in body condition identified as increased biomass. These responses are correlated to the expansion of SAT’s as coral cover declined, however, this relationship reverses if coral loss is high due to the succession of LAT’s over SAT’s and a corresponding decrease in the quality of food available. Our use of HTS has nevertheless identified the importance of detritivory in the flow of energy through reefs in the Anthropocene which are increasingly becoming depauperate in hard coral.

Identification of a delayed leaf greening gene from a mutation of pummelo - Hui-Wen Yu; Zhi-Hao Lu; Xia Wang; Dan Liu; Jia-Xian He; Xiao-Lin Jiang; Ling-Jun Ke; Wen-Wu Guo; Xiu-Xin Deng; Qiang Xu (Science China Life Sciences, 2021)

Identification and phylogenetic analysis of five Crataegus species (Rosaceae) based on complete chloroplast genomes - Liwei Wu; Yingxian Cui; Qing Wang; Zhichao Xu; Yu Wang; Yulin Lin; Jingyuan Song; Hui Yao (Planta, 2021)

Empathy-based tolerance towards poor norm violators in third-party punishment - Hui Ouyang; Jingqian Yu; Jipeng Duan; Li Zheng; Lin Li; Xiuyan Guo (Experimental Brain Research, 2021)

Cysteiniphilum marinum sp. nov., isolated from coastal seawater - Hai-Min Luo; Jun-Hui Feng; Liang-Hui Li; Meng-Meng Li; Ru-Qin Liu; Fu Chen; Ying Lin; Wen-Jun Li; Ping-Hua Qu; Min Xiao (Antonie van Leeuwenhoek, 2021)

A Review on the Emerging Asian Aquaculture Fish, the Malaysian Mahseer (Tor tambroides): Current Status and the Way Forward - Melinda Mei Lin Lau; Leonard Whye Kit Lim; Sairatul Dahlianis Ishak; Ambok Bolong Abol-Munafi; Hung Hui Chung (Proceedings of the Zoological Society, 2021)

Sleep Characteristics and Cerebrospinal Fluid Progranulin in Older Adults: The CABLE Study - Meng Wang; Fu-Rong Sun; Yan-Lin Bi; Ya-Hui Ma; Jian-Jun Yin; Xue-Ning Shen; Xiao-Tong Wang; Lan Tan; Jin-Tai Yu (Neurotoxicity Research, 2021)

Identification of Regeneration and Hub Genes and Pathways at Different Time Points after Spinal Cord Injury - Sheng Fang; Lin Zhong; An-quan Wang; Hui Zhang; Zong-Sheng Yin (Molecular Neurobiology, 2021)

Roles of bulk and rhizosphere denitrifying bacteria in denitrification from paddy soils under straw return condition - Ning Wang; Ya-Hui Zhao; Jian-Guang Yu; Li-Hong Xue; Hong-Bo Li; Lin-Zhang Yang (Journal of Soils and Sediments, 2021)

Alterinioella nitratireducens gen. nov., sp. nov., Isolated from Seawater in the West Pacific Ocean - Yan-Hui Kong; Cong Sun; Li-Li Guo; Lin Xu; Yue-Hong Wu; Xue-Wei Xu (Current Microbiology, 2021)

Ghrelin Affects Gastric Cancer Progression by Activating AMPK Signaling Pathway - Xiao-Lin Hu; Yong-Jun Zhu; Chang-Hua Hu; Li You; Juan Wu; Xiao-Yan He; Wen-Jie Huang; Zong-Hui Wu (Biochemical Genetics, 2021)

Temperature sensitivity of SOM decomposition is linked with a K‐selected microbial community - Hui Li; Shan Yang; Mikhail V. Semenov; Fei Yao; Ji Ye; Rencang Bu; Ruiao Ma; Junjie Lin; Irina Kurganova; Xugao Wang; Ye Deng; Irina Kravchenko; et al. (Global Change Biology, 2021)
Temperature sensitivity (Q 10 ) of soil organic matter (SOM) decomposition is a crucial parameter to predict the fate of soil carbon (C) under global warming. Nonetheless, the response pattern of Q 10 to continuous warming and the underlying mechanisms are still under debate, especially considering the complex interactions between Q 10 , SOM quality, and soil microorganisms. We examined the Q 10 of SOM decomposition across a mean annual temperature (MAT) gradient from −1.9 to 5.1°C in temperate mixed forest ecosystems in parallel with SOM quality and bioavailability, microbial taxonomic composition, and functional genes responsible for organic carbon decomposition. Within this temperature gradient of 7.0°C, the Q 10 values increased with MAT, but decreased with SOM bioavailability. The Q 10 values increased with the prevalence of K‐strategy of soil microbial community, which was characterized by: (i) high ratios of oligotrophic to copiotrophic taxa, (ii) ectomycorrhizal to saprotrophic fungi, (iii) functional genes responsible for degradation of recalcitrant to that of labile C, and (iv) low average 16S rRNA operon copy number. Because the recalcitrant organic matter was mainly utilized by the K‐strategists, these findings independently support the carbon quality‐temperature theory from the perspective of microbial taxonomic composition and functions. A year‐long incubation experiment was performed to determine the response of labile and recalcitrant C pools to warming based on the two‐pool model. The decomposition of recalcitrant SOM was more sensitive to increased temperature in southern warm regions, which might attribute to the dominance of K‐selected microbial communities. It implies that climate warming would mobilize the larger recalcitrant pools in warm regions, exacerbating the positive feedback between increased MAT and CO 2 efflux. This is the first attempt to link temperature sensitivity of SOM decomposition with microbial eco‐strategies by incorporating the genetic information and disentangling the complex relationship between Q 10 and soil microorganisms.

Computed Tomography Super-Resolution Using a Generative Adversarial Network in Bronchoscopy: A Clinical Feasibility Study - Heng-sheng Chao; Tsu-Hui Shiao; Chung-Wei Chou; Fang-Chi Lin; Yu-Te Wu; Der-Ming Liou (Journal of Medical and Biological Engineering, 2021)

Identification of two UDP-glycosyltransferases involved in the main oleanane-type ginsenosides in Panax japonicus var. major - Jun-Rong Tang; Geng Chen; Ying-Chun Lu; Qing-Yan Tang; Wan-Ling Song; Yuan Lin; Ying Li; Su-Fang Peng; Sheng-Chao Yang; Guang-Hui Zhang; Bing Hao (Planta, 2021)

New insights into the fine-scale history of western–eastern admixture of the northwestern Chinese population in the Hexi Corridor via genome-wide genetic legacy - Hongbin Yao; Mengge Wang; Xing Zou; Yingxiang Li; Xiaomin Yang; Ailin Li; Hui-Yuan Yeh; Peixin Wang; Zheng Wang; Jingya Bai; Jianxin Guo; Jinwen Chen; et al. (Molecular Genetics and Genomics, 2021)

Coupling InSAR and numerical modeling for characterizing landslide movements under complex loads in urbanized hillslopes - Peifeng Ma; Yifei Cui; Weixi Wang; Hui Lin; Yuanzhi Zhang (Landslides, 2021)

Targeted deletion of HAI-1 increases prostasin proteolysis but decreases matriptase proteolysis in human keratinocytes - Dajun D. Lu; Yayun Gu; Sheng-Wen A. Li; Robert J. Barndt; Shih-Ming Huang; Jehng-Kang Wang; Hui Chen Su; Michael D. Johnson; Chen-Yong Lin (Human Cell, 2021)

Pharmaceuticals and personal care products in the seawater around a typical subtropical tourist city of China and associated ecological risk - Hongzhe Chen; Wenfeng Chen; Huige Guo; Hui Lin; Yuanbiao Zhang (Environmental Science and Pollution Research, 2021)

Cracking behaviors and strength of rock-like samples with steps of different geometries under shear stress - Hui-lin Le; Ji-hong Wei; Shao-rui Sun; Chu-chu Zhang (Journal of Mountain Science, 2021)

Genome sequencing and functional annotation of Bacillus sp. strain BS-Z15 isolated from cotton rhizosphere soil having antagonistic activity against Verticillium dahliae - Zhong-Yi Chen; Xieerwanimu Abuduaini; Nuramina Mamat; Qi-Lin Yang; Meng-Jun Wu; Xin-Rui Lin; Ru Wang; Rong-Rong Lin; Wei-Jun Zeng; Huan-Chen Ning; He-Ping Zhao; Jin-Yu Li; et al. (Archives of Microbiology, 2021)

Effects of indole acetic acid on the growth and selenium absorption characteristics of Cyphomandra betacea seedlings - Yunmin Huan; Liu Yang; Qin Liu; Lijin Lin; Ming’an Liao; Zhihui Wang; Dong Liang; Hui Xia; Yi Tang; Xiulan Lv; Jin Wang (Acta Physiologiae Plantarum, 2021)

Microbial transformation of distinct exogenous substrates into analogous composition of recalcitrant dissolved organic matter - Jie Lian; Xiaoxuan Zheng; Xiaocun Zhuo; Yi‐Lung Chen; Chen He; Qiang Zheng; Ta‐Hui Lin; Jia Sun; Weidong Guo; Quan Shi; Nianzhi Jiao; Ruanhong Cai (Environmental Microbiology, 2021)
Summary Oceanic dissolved organic matter (DOM) comprises a complex molecular mixture which is typically refractory and homogenous in the deep layers of the ocean. Though the refractory nature of deep‐sea DOM is increasingly attributed to microbial metabolism, it remains unexplored whether ubiquitous microbial metabolism of distinct carbon substrates could lead to similar molecular composition of refractory DOM. Here, we conducted microbial incubation experiments using four typically bioavailable substrates (L‐alanine, trehalose, sediment DOM extract, and diatom lysate) to investigate how exogenous substrates are transformed by a natural microbial assemblage. The results showed that although each‐substrate‐amendment induced different changes in the initial microbial assemblage and the amended substrates were almost depleted after 90 days of dark incubation, the bacterial community compositions became similar in all incubations on day 90. Correspondingly, revealed by ultra‐high resolution mass spectrometry, molecular composition of DOM in all incubations became compositionally consistent with recalcitrant DOM and similar toward that of DOM from the deep‐sea. These results indicate that while the composition of natural microbial communities can shift with substrate exposures, long‐term microbial transformation of distinct substrates can ultimately lead to a similar refractory DOM composition. These findings provide an explanation for the homogeneous and refractory features of deep‐sea DOM.

Rosanortriterpenes A–B, two new nortriterpenes from the fruits of Rosa laevigata var. leiocapus - Yu-Nong Tian; Bai-Lin Li; Juan-Juan Hu; Jin-Dan Xie; Wen-Jing Xiao; Ling-Hui Nie; Jie-Wei Wu (Natural Product Research, 2021)

Human β-Defensin 118 Attenuates Escherichia coli K88–Induced Inflammation and Intestinal Injury in Mice - Qian Lin; Qingqing Fu; Xiang Li; Yuheng Luo; Junqiu Luo; Daiwen Chen; Xiangbing Mao; Bing Yu; Ping Zheng; Zhiqing Huang; Jie Yu; Hui Yan; et al. (Probiotics and Antimicrobial Proteins, 2021)

In Memory of Leslie G. Ungerleider - Ning Liu; Hui Zhang; Xilin Zhang; Jiongjiong Yang; Xuchu Weng; Lin Chen (Neuroscience Bulletin, 2021)

GTree: an Open-source Tool for Dense Reconstruction of Brain-wide Neuronal Population - Hang Zhou; Shiwei Li; Anan Li; Qing Huang; Feng Xiong; Ning Li; Jiacheng Han; Hongtao Kang; Yijun Chen; Yun Li; Huimin Lin; Yu-Hui Zhang; et al. (Neuroinformatics, 2021)

Phylogeny and taxonomy of two new Alternaria (Ascomycota: Pleosporaceae) species in section Gypsophilae from China - Lin He; Hong Cheng; Aye Aye Htun; Hui Ge; Zhen Zhou Xia; Jian Wei Guo; Jian Xin Deng; Tao Du (Mycological Progress, 2021)

The effect of cyfluthrin on testis inhibin B in rats and the intervention of Lycium barbarum polysaccharide - Xin Guo; Yong-Xin Xie; Chen Guo; Jing-Lin Wei; Hui-Fang Yang (Molecular & Cellular Toxicology, 2021)

Exendin-4 Reversed the PC12 Cell Damage Induced by circRNA CDR1as/miR-671/GSK3β Signaling Pathway - Hui Quan; Qiudan Chen; Kesheng Wang; Qinwan Wang; Meiling Lu; Yue Zhang; Sujing Qiang; Shaobo Xue; Lin Han; Huanhuan Zhu; Qiangyuan Fan; Meiyu Bao; et al. (Journal of Molecular Neuroscience, 2021)

Glycogen synthase kinase-3β (GSK-3β) deficiency inactivates the NLRP3 inflammasome-mediated cell pyroptosis in LPS-treated periodontal ligament cells (PDLCs) - Xiaolu Zhang; Shan He; Wanyu Lu; Lijia Lin; Hui Xiao (In Vitro Cellular & Developmental Biology - Animal, 2021)

Identification and characterization of CONSTANS-like genes from Curcuma alismatifolia - Yuan-Yuan Li; Xiao-Huang Chen; Hui-Wen Yu; Qi-Lin Tian; Luan-Mei Lu (Horticulture, Environment, and Biotechnology, 2021)

Increased depression risk for elderly women with high blood levels of strontium and barium - Jia Lv; Yan-ling Li; Wen-qiang Ren; Rong Li; Jian-rong Chen; Chao Bao; Zhi-ping Du; Shun Feng; Ling Gu; Hui Gao; Kai-yong Liu; Lin-sheng Yang; et al. (Environmental Chemistry Letters, 2021)

miR-23b Attenuates LPS-Induced Inflammatory Responses in Acute Lung Injury via Inhibition of HDAC2 - Zhi-Feng Luo; Xiang-Hui Jiang; Huan Liu; Li-Yuan He; Xiong Luo; Fu-Chun Chen; Yu-Lin Tan (Biochemical Genetics, 2021)

Western North Pacific Tropical Cyclone Database Created by the China Meteorological Administration - Xiaoqin Lu; Hui Yu; Ming Ying; Bingke Zhao; Shuai Zhang; Limin Lin; Lina Bai; Rijin Wan (Advances in Atmospheric Sciences, 2021)
This paper describes the access to, and the content, characteristics, and potential applications of the tropical cyclone (TC) database that is maintained and actively developed by the China Meteorological Administration, with the aim of facilitating its use in scientific research and operational services. This database records data relating to all TCs that have passed through the western North Pacific (WNP) and South China Sea (SCS) since 1949. TC data collection has expanded over recent decades via continuous TC monitoring using remote sensing and specialized field detection techniques, allowing collation of a multi-source TC database for the WNP and SCS that covers a long period, with wide coverage and many observational elements. This database now comprises a wide variety of information related to TCs, such as historical or real-time locations (i.e., best track and landfall), intensity, dynamic and thermal structures, wind strengths, precipitation amounts, and frequency. This database will support ongoing research into the processes and patterns associated with TC climatic activity and TC forecasting.

Estimating Chinese residential populations from analysis of impervious surfaces derived from satellite images - Shan Wei; Yinyi Lin; Hongsheng Zhang; Luoma Wan; Hui Lin; Zhifeng Wu (International Journal of Remote Sensing, 2021)

Environmental Effects on the Spatiotemporal Variability of Fish Larvae in the Western Guangdong Waters, China - Yuting Feng; Lijun Yao; Hui Zhao; Jing Yu; Zhaojin Lin (Journal of Marine Science and Engineering, 2021)
Spawning grounds occupy an important position in the survival and reproduction of aquatic life, which plays an important role in the replenishment of fishery resources, especially in the China coasts where fishery resources are depleting. This study investigated environmental effects on the spatiotemporal variability of fish larvae in the western Guangdong waters (WGWs), on the basis of generalized additive models (GAMs) and center of gravity (CoG). Satellite data including sea surface salinity (SSS), sea surface temperature (SST), and in situ observations for fish larvae from April to June in 2014–2015 were used. Results showed that 40.3% of the total variation in fish larvae density was explained. SST, SSS, and depth showed positive effects in 23–24 °C and 27–30 °C, 24–32 PSU, and 0–60 m, and showed negative effects in 24–27 °C, 32–34.2 PSU, 60–80 m. Based on the stepwise GAMs, the most important factor was month, with a contribution of 10.6%, followed by longitude, offshore distance, depth, and latitude, with contributions of 7.0%, 7.0%, 6.3%, 4.2%, 3.9%, and 1.3%, respectively. Fish larvae CoG shifted northward by 0.6° N and eastwards by 0.13° E from April to June. The distribution of fish larvae in the WGWs was affected by complex submarine topography in the Qiongzhou Strait, coastal upwelling in the WGWs, and runoff from the Pearl River.

Genome-Wide Analysis of the WRKY Transcription Factor Gene Family and Their Response to Salt Stress in Rubber Tree - Hong Nan; Yang-Lei Lin; Jin Liu; Hui Huang; Wei Li; Li-zhi Gao (Tropical Plant Biology, 2021)

Interest-activity symptom severity predicts response to ketamine infusion in treatment-resistant depression - Mu-Hong Chen; Wei-Chen Lin; Hui-Ju Wu; Ya-Mei Bai; Cheng-Ta Li; Shih-Jen Tsai; Chen-Jee Hong; Pei-Chi Tu; Tung-Ping Su (Psychopharmacology, 2021)

TRIC-A regulates intracellular Ca2+ homeostasis in cardiomyocytes - Xinyu Zhou; Ang Li; Pei-hui Lin; Jingsong Zhou; Jianjie Ma (Pflügers Archiv - European Journal of Physiology, 2021)
Trimeric intracellular cation (TRIC) channels have been identified as monovalent cation channels that are located in the ER/SR membrane. Two isoforms discovered in mammals are TRIC-A (TMEM38a) and TRIC-B (TMEM38b). TRIC-B ubiquitously expresses in all tissues, and TRIC-B −/− mice is lethal at the neonatal stage. TRIC-A mainly expresses in excitable cells. TRIC-A −/− mice survive normally but show abnormal SR Ca 2+ handling in both skeletal and cardiac muscle cells. Importantly, TRIC-A mutations have been identified in human patients with stress-induced arrhythmia. In the past decade, important discoveries have been made to understand the structure and function of TRIC channels, especially its role in regulating intracellular Ca 2+ homeostasis. In this review article, we focus on the potential roles of TRIC-A in regulating cardiac function, particularly its effects on intracellular Ca 2+ signaling of cardiomyocytes and discuss the current knowledge gaps.

Shallow gas hydrates off southwest Taiwan and their mechanisms - Yin-Sheng Huang; Shu-Kun Hsu; Chih-Chieh Su; Andrew Tien-Shun Lin; Pai-Sen Yu; Nathalie Babonneau; Gueorgui Ratzov; Serge Lallemand; Pi-Chuen Huang; Shiao-Shan Lin; Jing-Yi Lin; Kuo-Yen Wei; et al. (Marine Geophysical Research, 2021)
We have collected two shallow gas hydrate samples at two sites having different geological settings off southwest Taiwan during the cruise MD214 in 2018. The first core site, MD18-3542, is on the South Yuan-An East Ridge at ~ 1200 m water deep, where a structural unconformity covered by fine-silt sediments appears at ~ 5.5 m below the seafloor. The second core site, MD18-3543, is close to the Good-Weather Ridge at ~ 1100 m water deep, where a gas-related pockmark structure and authigenic carbonates are present at shallow strata with fine-silt sediments near the seafloor. Sediment properties of core MD18-3542 are distinctively different above and below the layer corresponding to the unconformity. Both cores show obvious gaps or voids in the lower core halves. The core features could be linked to the dissociated methane upward migrating from deep strata. Core site settings with upwelling methane would favor the formation of shallow gas hydrates. At site MD18-3542, the shallow hydrate could be formed due to high concentration methane kept beneath the unconformity covered by fine-silt sediments. At site MD18-3543, the shallow hydrate could be formed due to an extremely high flux of upwelling methane trapped either beneath the authigenic carbonates or fine-silt sediments.

Syndecan-3 contributes to the regulation of the microenvironment at the node of Ranvier following end-to‑side neurorrhaphy: sodium image analysis - Chiung-Hui Liu; Yu-Chen Kuo; Che-Yu Wang; Chao-Chun Hsu; Ying-Jui Ho; Yun-Chi Chiang; Fu-Der Mai; Wei-Jhih Lin; Wen-Chieh Liao (Histochemistry and Cell Biology, 2021)

Enhanced antioxidant capacity and upregulated transporter genes contribute to the UV-B-induced increase in blinin in Conyza blinii - Junyi Zhan; Qin Yang; Zhiyi Lin; Tianrun Zheng; Maojia Wang; Wenjun Sun; Tongliang Bu; Zizhong Tang; Chenglei Li; Xueyi Han; Haixia Zhao; Qi Wu; et al. (Environmental Science and Pollution Research, 2021)

Delayed association of acute particulate matter 2.5 air pollution exposure with loss of complexity in cardiac rhythm dynamics: insight from detrended fluctuation analysis - Tsung-Ying Tsai; Li-Wei Lo; Shin-Huei Liu; Wen-Han Cheng; Yu-Hui Chou; Wei-Lun Lin; Yenn-Jiang Lin; Shih-Lin Chang; Yu-Feng Hu; Fa-Po Chung; Jo-Nan Liao; Tze-Fan Chao; et al. (Environmental Science and Pollution Research, 2021)

Effects of Grazing, Wind Erosion, and Dust Deposition on Plant Community Composition and Structure in a Temperate Steppe - Mengmei Zheng; Jian Song; Jingyi Ru; Zhenxing Zhou; Mingxing Zhong; Lin Jiang; Dafeng Hui; Shiqiang Wan (Ecosystems, 2021)

Effects of degradation succession of alpine wetland on soil organic carbon and total nitrogen in the Yellow River source zone, west China - Chun-ying Lin; Xi-lai Li; Jing Zhang; Hua-fang Sun; Juan Zhang; Hui-bang Han; Qi-hua Wang; Cheng-biao Ma; Cheng-yi Li; Yu-xing Zhang; Xue-qian Ma (Journal of Mountain Science, 2021)

Identification of Aspergillus tubingensis causing pomegranate fruit rot in China - Mei Jun Guo; Qiu Tong Wang; Yuan Hui Cheng; Cheng Lin Hou (Australasian Plant Pathology, 2021)