PLXDC2 enhances invadopodium formation to promote invasion and metastasis of gastric cancer cells via interacting with PTP1B - Bin Wu; Yan-xia Wang; Jun-jie Wang; Dong-fang Xiang; Meng-si Zhang; Ze-xuan Yan; Wen-ying Wang; Jing-ya Miao; Xi Lan; Jia-jia Liu; Zheng-yan Li; Chuan Li; et al. (Clinical & Experimental Metastasis, 2022)
Plexin-domain containing 2 (PLXDC2) has been reported as an oncoprotein in several human malignancies. However, its expression and roles in gastric cancer remain largely unclear. In this study, we found that PLXDC2 was highly expressed in gastric cancer tissues, and the expression levels were positively correlated with clinicopathological features, but negatively with the patients’ outcome. Cox regression analysis identified PLXDC2 as an independent prognostic indicator for the patients. Knockdown of PLXDC2 markedly suppressed the in vitro invasion and in vivo metastasis of gastric cancer cells, while overexpression of PLXDC2 resulted in opposite effects. Mechanistically, PLXDC2 enhanced the level of phosphorylated Cortactin (p-Cortactin) by physically interacting with protein tyrosine phosphatase 1B (PTP1B), an important dephosphorylase, to prevent its dephosphorylating of p-Cortactin, thereby promoting the formation of invadopodia. Collectively, our results indicate that PLXDC2 contributes to the invasion and metastasis of gastric cancer by inhibiting PTP1B to facilitate the invadopodium formation, and may serve as a potential prognostic biomarker and a therapeutic target for this disease.

Cyclic experiments and global buckling design of steel-angle-assembled buckling-restrained braces - Jing-Zhong Tong; En-Yuan Zhang; Yan-Lin Guo; Chao-Qun Yu (Bulletin of Earthquake Engineering, 2022)

Oral Magnesium Supplementation for the Prevention of Preeclampsia: a Meta-analysis or Randomized Controlled Trials - Jing Yuan; Ying Yu; Tongyu Zhu; Xiaohan Lin; Xincheng Jing; Juan Zhang (Biological Trace Element Research, 2022)

Lelliottia steviae sp. nov. isolated from Stevia rebaudiana Bertoni - Jing Lin; Ke Huang; Jing-Yu Huang; Yuan-Ru Xiong; Meng-Meng Wei; Na Xiao; Jia Gao; Xuan-Kai Ding; Zi-Yang Ma; Jun-Hao Sang; Ling-Xian Kong; Zhi-Yun Hong; et al. (Archives of Microbiology, 2022)

Vertical patterns of chlorophyll a in the euphotic layer are related to mesoscale eddies in the South China Sea - Mei-Lin Wu; You-Shao Wang; Yu-Tu Wang; Fu-Lin Sun; Xiaomei Li; Fang-Fang Gu; Jing-Chang Xiang (Frontiers in Marine Science, 2022)
Phytoplankton closely connects with the hydrodynamics and biogeochemical environment of the ocean. While research focusing on both the physiochemical factors and hydrodynamics regulating phytoplankton has already been conducted, the coupling mechanism between mesoscale eddies and the vertical distribution of phyto plankton in the South China Sea (SCS) is still not well understood. Here, phytoplankton was studied under one weak-cold and two warm eddies along the 18°N transect in the SCS. The results show that the vertical distribution of chlorophyll (chl- a ) presented a similar pattern at all four sampling stations. The mixed layer is less than 50 m. It is the same as the meridional salinity gradients that may be distinguished above a depth of 60 m. The subsurface chlorophyll maximum at the edge of a warm (WI) and cold eddy (CI) at E413 and E411 was shallower than that at the edge of a warm eddy (WII) at E407 and E409, indicating that temperature and salinity may be the important driving factors. On the whole, mesoscale eddies had a significant influence on the vertical pattern of chl- a in the SCS during the study period.

Isolation and identification of two new sargentodoxosides from Sargentodoxa cuneata and their agonistic effects against FXR - Wen Zhang; Cheng-Peng Sun; Yu-Lin Peng; Wen-Yu Zhao; Zheng-Yue Wang; Jing Ning; Xia Lv; Zhen-Long Yu; Shuang Zhou; Wei Peng; Bang-Jiang Fang; Xiao-Chi Ma (Natural Product Research, 2022)

Fissistiganoids A and B: two new flavonoids from the Fissistigma tungfangense - Wan-Lin Zhong; Xue-Ming Zhou; Ji-Ling Yi; Xin-Ming Song; Bin Zhang; Jing-Yu Yang; Guang-Ying Chen (Natural Product Research, 2022)

Structure elucidation of a novel cyclic tripeptide from the marine-derived fungus Aspergillus ochraceopetaliformis DSW-2 - Yanyan Liao; Xuan Hong; Jing Yang; Jiang-Jiang Qin; Beibei Zhang; Jianhui Lin; Zongze Shao; Weiyi Wang (Natural Product Research, 2022)

A Review of the Development of Key Technologies for Offshore Wind Power in China - Qixiang Fan; Xin Wang; Jing Yuan; Xin Liu; Hao Hu; Peng Lin (Journal of Marine Science and Engineering, 2022)
In recent years, Offshore Wind Power (OWP) has gained prominence in China’s national energy strategy. However, the levelized cost of electricity (LCoE) of wind power must be further reduced to match the average wholesale price. The cost-cutting and revenue-generating potential of offshore wind generation depends on technological innovation. The most recent studies and applications of offshore wind technology are thoroughly examined. (1) Techniques for site selection, such as site surveys, wind resource assessments, and environmental factors, are reviewed. (2) Three main technical components in offshore wind farms are discussed, including wind turbine, foundations, and booster stations. (3) The state-of-the-art method of the offshore wind farm’s construction and operation and maintenance (O&M) practices is discussed. In situ marine geological surveying, large-scale offshore wind turbine manufacturing, integrated structural design, floating foundation design, flexible DC transmission technology, shortage of specialized vessels and equipment for construction, intelligence of O&M, and other issues are challenging China’s OWP industry. A brief overview of China’s efforts in standardization, parity, and research and development are discussed. Recommendations for future development of the wind power industry are provided for China, which may be referable for other nations with comparable circumstances.

Metatranscriptomic analysis of host response and vaginal microbiome of patients with severe COVID-19 - Meng Xiao; Bo Lu; Rui Ding; Xia Liu; Xian Wu; Yaqian Li; Xudong Liu; Lin Qiu; Zhibo Zhang; Jing Xie; Yu Chen; Dong Zhang; et al. (Science China Life Sciences, 2022)

Trends and status in resources security, ecological stability, and sustainable development research: a systematic analysis - Xinyu Kang; Minxi Wang; Jing Lin; Xin Li (Environmental Science and Pollution Research, 2022)

Recognition of the Multi-class Schizophrenia Based on the Resting-State EEG Network Topology - Fali Li; Lin Jiang; Yuanyuan Liao; Cunbo Li; Qi Zhang; Shu Zhang; Yangsong Zhang; Li Kang; Rong Li; Dezhong Yao; Gang Yin; Peng Xu; et al. (Brain Topography, 2022)

Testing the transfer functions for the Geonor T-200B and Chinese standard precipitation gauge in the central Qinghai—Tibet Plateau - Le-le Zhang; Li-ming Gao; Ji Chen; Lin Zhao; Ke-long Chen; Jing-yi Zhao; Guo-jun Liu; Ting-xi Song; Yan-kun Li (Journal of Mountain Science, 2022)

Discovery of the non‐cosmopolitan lineages in Candidatus Thermoprofundales - Yi‐Fan Liu; Liu Yang; Zhong‐Lin Liu; Jing Chen; Bo Fang; Lei Zhou; Jin‐Feng Liu; Shi‐Zhong Yang; Ji‐Dong Gu; Bo‐Zhong Mu (Environmental Microbiology, 2022)
Summary The recently proposed order Candidatus Thermoprofundales, currently containing only one family‐level lineage Marine Benthic Group‐D (MBG‐D), is distributed in global subsurface ecosystems and ecologically important, but its diversity, evolution and metabolism remain largely unknown. Here we described two novel family‐level specialized lineages in Ca . Thermoprofundales, JdFR‐43 and HyVt, which are restricted to specific biotopes (primarily in marine hydrothermal vents and occasionally in oil reservoirs and hot springs) in contrast to the cosmopolitan lineage MBG‐D. The comparative genomics revealed that the specialized lineages have streamlined genomes, higher GC contents, enriched genes associated with nucleotide biosynthesis, ribosome biogenesis and DNA repair and additional thermostable aminopeptidases, enabling them to adapt to high‐temperature habitats such as marine hydrothermal vents, deep subsurface oil reservoirs and hot springs. On the contrary, the unique metabolic traits of the cosmopolitan MBG‐D, motility, glycolysis, butanoate metabolism, secondary metabolites production and additional genes for specific peptides and carbohydrates degradation potentially enhance its response to environmental change. Substrate preference is found for most MAGs across all lineages with the ability to utilize both polysaccharides (chitin and starch) and proteinaceous substances, whereas JdFR‐43 members from oil reservoirs can only utilize proteins. These results expand the diversity of C a . Thermoprofundales significantly and further improve our understandings of the adaptations of C a . Thermoprofundales to various environments.

Sandstorms cause shrinkage of Haloxylon ammodendron shrubs and limit their self-renewal - Sheng-bo Shi; Dang-wei Zhou; Fang-lin Wang; Rui Shi; Tao Sun; Tian-cai Li; Jia-lin Ma; Xiang Wan; Jian-ping Ma; Jing-nian Tang (Theoretical and Experimental Plant Physiology, 2022)
Haloxylon ammodendron is an excellent windproof and sand-fixing species whose shrubs are widely cultivated in arid desert areas of northwest China but are now at risk of degradation and shrinkage. Using the chlorophyll fluorescence image analysis technique, the response of photosystem II (PSII) photochemical efficiency and non-photochemical quenching capacity to sediment-carrying wind and sand-free wind (both 12 m s −1 ) lasting for 10, 20, and 40 min were studied with seedlings in a wind tunnel. The results indicated that the sand-free wind had little influence on the maximum quantum efficiency of PSII photochemistry, F v / F m , which was approximately 0.80 on average; however, the F v / F m decreased over exposure time in the sediment-carrying wind group, with values smaller than those in the wind-only group. The non-photochemical quenching was sensitive to wind erosion, and sediment-carrying wind could aggravate the reduction in non-photochemical quenching ( NPQ ). Except for the 10 min duration, the maximum quantum efficiency of PSII photochemistry after dark recovery for 15 min, F v r / F m r , was lower in seedlings exposed to sediment-carrying wind than in those in the wind-only group. Compared to wind-only, wind-blown sand led to a water imbalance and withering in seedlings, causing the concentration of photosynthetic pigments (when based on the fresh mass of green branches) to not decrease. With a longer exposure time to sediment-carrying wind, both the probability and extent of lignified spots occurring increased in green assimilative branches. Our results demonstrated that sediment-carrying wind at 12 m s −1 lasting for 20 min or more could cause irreversible damage to the photosynthetic apparatus of H. ammodendron seedlings. Therefore, frequent and strong sandstorms are the main disturbance factors leading to shrinkage of shrubs and limiting their self-renewal.

Rainfall Variability Index (RVI) analysis of dry spells in Malaysia - Yuk Feng Huang; Ali Najah Ahmed; Jing Lin Ng; Kok Weng Tan; Pavitra Kumar; Ahmed El-Shafie (Natural Hazards, 2022)

Emerging role of exosomal long non-coding RNAs in lung cancer - Lulu He; Minmin Lin; Jing Shen; Hongyan Qi (Molecular Biology Reports, 2022)

A Combined Proteomics and Metabolomics Profiling to Investigate the Genetic Heterogeneity of Autistic Children - Liming Shen; Huajie Zhang; Jing Lin; Yan Gao; Margy Chen; Naseer Ullah Khan; Xiaoxiao Tang; Qi Hong; Chengyun Feng; Yuxi Zhao; Xueshan Cao (Molecular Neurobiology, 2022)

Grazing by Tibetan Sheep Enhances Soil Bacterial and Fungal Diversity in Cold Season Pastures of Alpine Meadows on the Northern Qinghai–Tibetan Plateau - Lin Wang; Xiaojun Yu; Changlin Xu; Yuanyuan Jing; Meijuan Song (Journal of Soil Science and Plant Nutrition, 2022)

Detection of bloom-forming dinoflagellates Karenia mikimotoi and Prorocentrum donghaiense using qPCR assays - Xiao-Kun Hu; Zhuo-Ru Lin; Qing-Chun Zhang; Fan-Zhou Kong; Jing-Yi Cen; Yu-Lan Zeng; Ren-Cheng Yu (Journal of Applied Phycology, 2022)

Estrogen Deficiency Aggravates Fluoride-Induced Liver Damage and Lipid Metabolism Disorder in Rats - Ya-ming Yu; Bian-hua Zhou; Yi-lin Yang; Cheng-Xiang Guo; Jing Zhao; Hong-wei Wang (Biological Trace Element Research, 2022)

A patchy-saturated rock physics model for tight sandstone based on microscopic pore structures - Chun-Fang Wu; Jing Ba; José M. Carcione; Tobias M. Müller; Lin Zhang (Applied Geophysics, 2022)

Intelligent identification method and application of seismic faults based on a balanced classification network - Jing Yang; Ren-Wei Ding; Hui-Yong Wang; Nian-Tian Lin; Li-Hong Zhao; Shuo Zhao; Yu-Jie Zhang (Applied Geophysics, 2022)

Distinct Evolution of the SST Anomalies in the Far Eastern Pacific between the 1997/98 and 2015/16 Extreme El Niños - Shaolei Tang; Jing-Jia Luo; Lin Chen; Yongqiang Yu (Advances in Atmospheric Sciences, 2022)

Optimization of aquaculture sustainability through ecological intensification in China - Shuang‐lin Dong; Yun‐wei Dong; Ling Cao; Johan Verreth; Yngvar Olsen; Wen‐jing Liu; Qi‐zhi Fang; Yan‐gen Zhou; Li Li; Jing‐yu Li; Yong‐tong Mu; Patrick Sorgeloos (Reviews in Aquaculture, 2022)
As the world's leading producer of farmed aquatic food products, China faces great uncertainty concerning the further sustainable development of its aquaculture industry due to high and increasing pressure from environmental and resource constraints. To realize truly sustainable development, it is imperative to establish an evaluation system that integrates social, economic, environmental and resource criteria, and optimizes aquaculture systems through a holistic approach. Here, we used analytical hierarchy processes combined with expert judgment and objective data to assess the sustainability of 10 major aquaculture production systems (APSs) in China. Based on the evaluation results, we propose the ecological intensification of aquaculture systems (ELIAS), rationally integrating anthropogenic inputs with aquaculture ecosystem services, to improve the sustainability of APSs. The holistic evaluation system and ELIAS are fundamental and critical for the future development of aquaculture in China and globally.

Cover Image, Volume 14, Issue 3 - Shuang‐lin Dong; Yun‐wei Dong; Ling Cao; Johan Verreth; Yngvar Olsen; Wen‐jing Liu; Qi‐zhi Fang; Yan‐gen Zhou; Li Li; Jing‐yu Li; Yong‐tong Mu; Patrick Sorgeloos (Reviews in Aquaculture, 2022)
The cover image is based on the Review Article Optimization of aquaculture sustainability through ecological intensification in China by Shuang‐lin Dong et al., https://doi.org/10.1111/raq.12648 image

First report of chilli veinal mottle virus infecting tobacco in Guizhou, China - Yue Chen; Ting Ting Li; Jing Zhong; Li Ling Zhao; Ya Li Guo; Ye Chun Lin; Gui Gao; Yi Cao; Ming Ding (Journal of Plant Pathology, 2022)

Autoimmune Cerebellar Ataxia: Etiology and Clinical Characteristics of a Case Series from China - Mange Liu; Haitao Ren; Yicheng Zhu; Siyuan Fan; Lin Bai; Jing Wang; Liying Cui; Hongzhi Guan (The Cerebellum, 2022)

Development of novel polymorphic microsatellite markers for Picea brachytyla - Shuai-Peng Si; Chun-Jing Wang; Ji-Zhong Wan; Yu-Lin Qian; Chun-Hui Zhang (Molecular Biology Reports, 2022)

Proteomic characterization of four subtypes of M2 macrophages derived from human THP-1 cells - Pengfei Li; Chen Ma; Jing Li; Shanshan You; Liuyi Dang; Jingyu Wu; Zhifang Hao; Jun Li; Yuan Zhi; Lin Chen; Shisheng Sun (Journal of Zhejiang University-SCIENCE B, 2022)

The genes for sensory perception of sound should be considered in gene diagnosis of congenital sensorineural hearing loss and microtia - Ken Lin; Ding-Yun You; Li-Huan Zhang; Li-Juan Zhou; Jin-Yan Zu; Yang Xiao; Mei-Hua Sun; Dong-Su; Xue Cao; Tie-Song Zhang; Jing Ma (Journal of Applied Genetics, 2022)

Epidemiological characteristics of gonorrhea and its influential meteorological factors: a 14-year retrospective assessment in China - Jin Bu; Liang-Jia Zhou; Xiang Xiao; Qian Yue; Gang Hu; Pei Jiang; Jing Chen; Yu Lin (Environmental Science and Pollution Research, 2022)

Mixed effects of perfluoroalkyl and polyfluoroalkyl substances exposure on cognitive function among people over 60 years old from NHANES - Xueqiong Weng; Huanzhu Liang; Yuxuan Tan; Jingmin Chen; Qiaoyuan Fei; Shan Liu; Xinrong Guo; Lin Wen; Yingying Wu; Chunxia Jing (Environmental Science and Pollution Research, 2022)

Short-term variations and influencing factors of suspended sediment concentrations at the Heisha Beach, Guangdong, China - Jintang Ou; Haoyan Dong; Liangwen Jia; Xiangxin Luo; Zixiao He; Kanglin Chen; Jing Liu; Yitong Lin; Mingdong Yu; Mingen Liang (Acta Oceanologica Sinica, 2022)

Delayed rFGF21 Administration Improves Cerebrovascular Remodeling and White Matter Repair After Focal Stroke in Diabetic Mice - Yinghua Jiang; Jinrui Han; Yadan Li; Yinga Wu; Ning Liu; Samuel X. Shi; Li Lin; Jing Yuan; Shusheng Wang; Ming-Ming Ning; Aaron S. Dumont; Xiaoying Wang (Translational Stroke Research, 2022)

Genetic Diversity Analysis of Sugarcane (Saccharum spp. hybrids) Among High-Sucrose Clones of GT Series and Commonly Used Parents by Using Microsatellite Markers in Guangxi, China - Hai-Rong Huang; Yi-Jing Gao; Mukesh Kumar Malviya; Krishan K. Verma; Manoj Kumar Solanki; Yu-Xin Huang; Xiang Li; Yuchi Deng; Jing Yan; Shi-Yun Tang; Lun-Wang Wang; Lin Xu (Sugar Tech, 2022)

Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China - Pengfei Cui; Xianying Zeng; Xuyong Li; Yanbing Li; Jianzhong Shi; Conghui Zhao; Zhiyuan Qu; Yanwen Wang; Jing Guo; Wenli Gu; Qi Ma; Yuancheng Zhang; et al. (Science China Life Sciences, 2022)
The H5N8 avian influenza viruses have been widely circulating in wild birds and are responsible for the loss of over 33 million domestic poultry in Europe, Russia, Middle East, and Asia since January 2020. To monitor the invasion and spread of the H5N8 virus in China, we performed active surveillance by analyzing 317 wild bird samples and swab samples collected from 41,172 poultry all over the country. We isolated 22 H5N8 viruses from wild birds and 14 H5N8 viruses from waterfowls. Genetic analysis indicated that the 36 viruses formed two different genotypes: one genotype viruses were widely detected from different wild birds and domestic waterfowls; the other genotype was isolated from a whopper swan. We further revealed the origin and spatiotemporal spread of these two distinct H5N8 virus genotypes in 2020 and 2021. Animal studies indicated that the H5N8 isolates are highly pathogenic to chickens, mildly pathogenic in ducks, but have distinct pathotypes in mice. Moreover, we found that vaccinated poultry in China could be completely protected against H5N8 virus challenge. Given that the H5N8 viruses are likely to continue to spread in wild birds, vaccination of poultry is highly recommended in high-risk countries to prevent H5N8 avian influenza.

Follicular Fluid-Derived Exosomal MicroRNA-18b-5p Regulates PTEN-Mediated PI3K/Akt/mTOR Signaling Pathway to Inhibit Polycystic Ovary Syndrome Development - Zhi Zhou; Zhihua Tu; Juan Zhang; Can tan; Xiaoyong Shen; Bangbei Wan; Yejuan Li; Anguo Wang; Liqiang Zhao; Jiajia Hu; Ning Ma; Jing Zhou; et al. (Molecular Neurobiology, 2022)

HIF-1α aggravates pathologic myopia through the miR-150-5p/LAMA4/p38 MAPK signaling axis - Yalin Ren; Xiaobo Yang; Zhi Luo; Jing Wu; Haiyan Lin (Molecular and Cellular Biochemistry, 2022)

Correction: Interaction of declined handgrip strength and HIV infection on neurocognitive impairment - Shiying Yuan; Xiaoxiao Chen; Haijiang Lin; Ruizi Shi; Jing Li; Lulu Xu; Shijie Qiao; Yingying Ding; Na He (Journal of NeuroVirology, 2022)

Interaction of declined handgrip strength and HIV infection on neurocognitive impairment - Shiying Yuan; Xiaoxiao Chen; Haijiang Lin; Ruizi Shi; Jing Li; Lulu Xu; Shijie Qiao; Yingying Ding; Na He (Journal of NeuroVirology, 2022)

Haloprofundus salilacus sp. nov., Haloprofundus halobius sp. nov. and Haloprofundus salinisoli sp. nov.: three extremely halophilic archaea isolated from salt lake and saline soil - Si-Ya Li; Yu-Jie Xin; Chen-Xi Bao; Jing Hou; Heng-Lin Cui (Extremophiles, 2022)

Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated Encephalopathy by Promoting Ferroptosis Through Regulating miR-9-5p/TFRC and GOT1 Axis - Xue-biao Wei; Wen-qiang Jiang; Ju-hao Zeng; Lin-qiang Huang; Hong-guang Ding; Yuan-wen Jing; Yong-li Han; Yi-chen Li; Sheng-long Chen (Molecular Neurobiology, 2022)
Sepsis can cause sepsis-associated encephalopathy (SAE), but whether SAE was induced or exacerbated by ferroptosis remains unknown. In this study, the rat sepsis model was constructed using the cecal ligation and puncture method. The blood–brain barrier (BBB) permeability was measured by Evans blue dye (EBD) in vivo. The levels of ROS, Fe ion, MDA, GSH, and GPX4 were assessed by enzyme-linked immunosorbent assay (ELISA). The exosomes isolated from serum were cultured with bEnd.3 cells for the in vitro analysis. Moreover, bEnd.3 cells cultured with 100 μM FeCl3 (iron-rich) were to simulate ferroptosis stress. The cell viability was evaluated by Cell Counting Kit-8 (CCK-8) assay. A dual-luciferase reporter gene assay was performed to confirm the relationship between miR-9-5p with NEAT1, TFRC , and GOT1 . In vivo, it is found that BBB permeability was damaged in model rats. Level of ROS, Fe ion, and MDA was increased, and level of GSH and GPX4 was decreased, which means ferroptosis was induced by sepsis. Exosome-packaged NEAT1 in serum was significantly upregulated in model rats. In vitro, it is found that NEAT1 functions as a ceRNA for miR-9-5p to facilitate TFRC and GOT1 expression. Overexpression of NEAT1 enhanced ferroptosis stress in bEnd.3 cells. Increased miR-9-5p alleviated sepsis-induced ferroptosis by suppressing the expression of TFRC and GOT1 both in vivo and in vitro. In conclusion, these findings suggest that sepsis induced high expression of serous exosome-derived NEAT1, and it might exacerbate SAE by promoting ferroptosis through regulating miR-9-5p/ TFRC and GOT1 axis.

Hippocampal SIRT1-Mediated Synaptic Plasticity and Glutamatergic Neuronal Excitability Are Involved in Prolonged Cognitive Dysfunction of Neonatal Rats Exposed to Propofol - Lin-Hui Ma; Jie Wan; Jing Yan; Ning Wang; Yan-Ping Liu; Hai-Bi Wang; Cheng-Hua Zhou; Yu-Qing Wu (Molecular Neurobiology, 2022)

Enhancement of oral bioavailability and anti-hyperuricemic activity of aloe emodin via novel Soluplus®—glycyrrhizic acid mixed micelle system - Feng Shi; Lin Chen; Yaping Wang; Jing Liu; Michael Adu-Frimpong; Hao Ji; Elmurat Toreniyazov; Qilong Wang; Jiangnan Yu; Ximing Xu (Drug Delivery and Translational Research, 2022)

A bi-scale assessing framework for aesthetic ecosystem services of villages in a world heritage site - Yin-ping Ding; Zhi-lin Liu; Yuan-mei Jiao; Qiu-e Xu; Kan-feng Zhang; Cheng-jing Liu; Fan Chen (Journal of Mountain Science, 2022)

Consistency correction of echo intensity data for multiple radar systems and its application in quantitative estimation of typhoon precipitation - Shuai Zhang; Jing Han; Bingke Zhao; Zhigang Chu; Jie Tang; Limin Lin; Xiaoqin Lu; Jiaming Yan (Frontiers of Earth Science, 2022)

Genomic characterization of a new enamovirus infecting common bean - Ruo-bin Lu; Ping-xiu Lan; Ru-jing Kang; Guan-lin Tan; Xiao-jiao Chen; Ruhui Li; Fan Li (Archives of Virology, 2022)

Complete genome analysis of the novel Alcaligenes faecalis phage vB_AfaP_QDWS595 - Yujie Jing; Hong Lin; Houqi Ning; Jingxue Wang (Archives of Virology, 2022)

MoOpy2 is essential for fungal development, pathogenicity, and autophagy in Magnaporthe oryzae - Ying‐Ying Cai; Jing‐Yi Wang; Xi‐Yu Wu; Shuang Liang; Xue‐Ming Zhu; Lin Li; Jian‐Ping Lu; Xiao‐Hong Liu; Fu‐Cheng Lin (Environmental Microbiology, 2022)
Summary The development and pathogenicity of the fungus Magnaporthe oryzae , the causal agent of destructive rice blast disease, require it to perceive external environmental signals. Opy2, an overproduction‐induced pheromone‐resistant protein 2, is a crucial protein for sensing external signals in Saccharomyces cerevisiae . However, the biological functions of the homologue of Opy2 in M. oryzae are unclear. In this study, we identified that MoOPY2 is involved in fungal development, pathogenicity, and autophagy in M. oryzae . Deletion of MoOPY2 resulted in pleiotropic defects in hyphal growth, conidiation, germ tube extension, appressorium formation, appressorium turgor generation, and invasive growth, therefore leading to attenuated pathogenicity. Furthermore, MoOpy2 participates in the Osm1 MAPK pathway and the Mps1 MAPK pathway by interacting with the adaptor protein Mst50. The interaction sites of Mst50 and MoOpy2 colocalized with the autophagic marker protein MoAtg8 in the preautophagosomal structure sites (PAS). Notably, the Δ Moopy2 mutant caused cumulative MoAtg8 lipidation and rapid GFP‐MoAtg8 degradation in response to nitrogen starvation, showing that MoOpy2 is involved in the negative regulation of autophagy activity. Taken together, our study revealed that MoOpy2 of M. oryzae plays an essential role in the orchestration of fungal development, appressorium penetration, autophagy and pathogenesis.

Downregulated Calcium-Binding Protein S100A16 and HSP27 in Placenta-Derived Multipotent Cells Induce Functional Astrocyte Differentiation - Yu-Che Cheng; Chi-Jung Huang; Wei-Chi Ku; Shu-Lin Guo; Lu-Tai Tien; Yih-Jing Lee; Chih-Cheng Chien (Stem Cell Reviews and Reports, 2022)
Little is known about genes that induce stem cells differentiation into astrocytes. We previously described that heat shock protein 27 (HSP27) downregulation is directly related to neural differentiation under chemical induction in placenta-derived multipotent stem cells (PDMCs). Using this neural differentiation cell model, we cross-compared transcriptomic and proteomic data and selected 26 candidate genes with the same expression trends in both omics analyses. Those genes were further compared with a transcriptomic database derived from Alzheimer’s disease (AD). Eighteen out of 26 candidates showed opposite expression trends between our data and the AD database. The mRNA and protein expression levels of those candidates showed downregulation of HSP27, S100 calcium-binding protein A16 (S100A16) and two other genes in our neural differentiation cell model. Silencing these four genes with various combinations showed that co-silencing HSP27 and S100A16 has stronger effects than other combinations for astrocyte differentiation. The induced astrocyte showed typical astrocytic star-shape and developed with ramified, stringy and filamentous processes as well as differentiated endfoot structures. Also, some of them connected with each other and formed continuous network. Immunofluorescence quantification of various neural markers indicated that HSP27 and S100A16 downregulation mainly drive PDMCs differentiation into astrocytes. Immunofluorescence and confocal microscopic images showed the classical star-like shape morphology and co-expression of crucial astrocyte markers in induced astrocytes, while electrophysiology and Ca 2+ influx examination further confirmed their functional characteristics. In conclusion, co-silencing of S100A16 and HSP27 without chemical induction leads to PDMCs differentiation into functional astrocytes. Graphical abstract

Rrn3 gene knockout affects ethanol-induced locomotion in adult heterozygous zebrafish - Fei Li; Jia Lin; Tingting Li; Jing Jian; Qi Zhang; Yinglan Zhang; Xiuyun Liu; Qiang Li (Psychopharmacology, 2022)

The complete mitochondrial genome of Crassostrea hongkongensis from East China Sea indicates species’ range may extend northward - Sheng Liu; Youli Liu; Jing He; Zhihua Lin; Qinggang Xue (Molecular Biology Reports, 2022)

Comparatively analyzing the liver-specific transcriptomic profiles in Kunming mice afflicted with streptozotocin- and natural food-induced type 2 diabetes mellitus - Yanjun Wu; Xiangxing Zhu; Arome Solomon Odiba; Zisheng Lin; Jiancong Wen; Daoyuan Gong; Jing Liang; Shuguang Wu; Ganqiu Lan (Molecular Biology Reports, 2022)

Autophagy plays a double-edged sword role in liver diseases - Jing-chao Zhou; Jing-lin Wang; Hao-zhen Ren; Xiao-lei Shi (Journal of Physiology and Biochemistry, 2022)
As a highly evolutionarily conserved process, autophagy can be found in all types of eukaryotic cells. Such a constitutive process maintains cellular homeostasis in a wide variety of cell types through the encapsulation of damaged proteins or organelles into double-membrane vesicles. Autophagy not only simply eliminates materials but also serves as a dynamic recycling system that produces new building blocks and energy for cellular renovation and homeostasis. Previous studies have primarily recognized the role of autophagy in the degradation of dysfunctional proteins and unwanted organelles. However, there are findings of autophagy in physiological and pathological processes. In hepatocytes, autophagy is not only essential for homeostatic functions but also implicated in some diseases, such as viral hepatitis, alcoholic hepatitis, and hepatic failure. In the present review, we summarized the molecular mechanisms of autophagy and its role in several liver diseases and put forward several new strategies for the treatment of liver disease.

Synthesis of Silver- and Strontium-Substituted Hydroxyapatite with Combined Osteogenic and Antibacterial Activities - Yunfei Li; Wenying Wang; Jing Han; Zirui Li; Qiuxiang Wang; Xue Lin; Kun Ge; Guoqiang Zhou (Biological Trace Element Research, 2022)

The Flavor and Antioxidant Activity Change Pattern of Shrimp Head Paste During Fermentation - Jing Yu; Kuan Lu; Jinyuan Sun; Wancui Xie; Lin Song; Hongxia Che (Journal of Ocean University of China, 2022)

Unemployment rate, clean energy, and ecological footprint in OECD countries - Cheong-Fatt Ng; Kwang-Jing Yii; Lin-Sea Lau; You-How Go (Environmental Science and Pollution Research, 2022)

Larval Fish Assemblages and Distribution Patterns in the Zhongsha Atoll (Macclesfield Bank, South China Sea) - Delian Huang; Jing Chen; Lei Xu; Xuehui Wang; Jiajia Ning; Yafang Li; Lianggen Wang; Shuangshuang Liu; Zhaojin Lin; Feiyan Du (Frontiers in Marine Science, 2022)
The remote coral reef in the deep sea is one of the most important nursery grounds for many marine fishes in the South China Sea. Diversity studies on larval fishes in this area are few, and the fish information on the coral reefs ecosystem is lacking. In this study, larval fishes were sampled during the summer of 2019 from the Zhongsha Atoll in the South China Sea and identified using DNA barcodes for the first time. Ninety-five larval fish species were recognized, belonging to 37 families and 12 orders based on morphological classification and DNA barcoding identification. The larval fish collected could be assigned to three categories as reef-associated, deep-sea, and pelagic. Most of the species were small fish with low commercial value but would play an essential role in the coral reef ecosystem. Some commercial fishes, including Auxis thazard, Euthynnus affinis, Sarda orientalis, Decapterus macarellus, Lutjanus viridis , and Centropyge vrolikii , were the dominant species higher than 2% total catch. The larval fish assemblage showed distinct spatial differences responding well with the geographical conditions. The most reef-associated fish occurred inside the Atoll, and the abyssal fish presented near the edge. In addition, larval fish spread over from the southwest to northeast may reflect the oceanography effect.

Two new triterpenoid-chromone hybrids from the rhizomes of Actaea cimicifuga L. (syn. Cimicifuga foetida L.) and their cytotoxic activities - Qiang-Qiang Shi; Ya Gao; Jing Lu; Lin Zhou; Ming-Hua Qiu (Natural Product Research, 2022)

The role of social networks in relocation induced by climate-related hazards: an empirical investigation in China - Jing Tan; Kui Zhou; Li Peng; Lei Lin (Climate and Development, 2022)

Highly selective monoclonal antibody-based lateral flow immunoassay for visual and sensitive determination of conazole fungicides propiconazole in vegetables - Ze-Ke Xu; Jing-Nan Meng; Yi Lei; Xing-Xing Yang; Yi-Yong Yan; Hai-Hong Liu; Hong-Tao Lei; Ting-Cai Wang; Xing Shen; Zhen-Lin Xu (Food Additives & Contaminants: Part A, 2022)

Correction to: Pharmacological stimulation of sigma-1 receptor promotes activation of astrocyte via ERK1/2 and GSK3β signaling pathway - Yun Wang; Hua-feng Jiang; Jing Ni; Lin Guo (Naunyn-Schmiedeberg's Archives of Pharmacology, 2022)

Integrated smart robot with earthquake early warning system for automated inspection and emergency response - Tzu-Hsuan Lin; Jing-Ting Huang; Alan Putranto (Natural Hazards, 2022)

An evaluation of various data pre-processing techniques with machine learning models for water level prediction - Ervin Shan Khai Tiu; Yuk Feng Huang; Jing Lin Ng; Nouar AlDahoul; Ali Najah Ahmed; Ahmed Elshafie (Natural Hazards, 2022)

Adaptations of Plutella xylostella adult females and larvae to waxy host plants - Jing-Yun Zhu; Zhong-Wen Xiang; Shi-Ze Zhang; Lin-Nan Wu; Tong-Xian Liu (Journal of Pest Science, 2022)

Parallel Metabolomic Profiling of Cerebrospinal Fluid, Plasma, and Spinal Cord to Identify Biomarkers for Spinal Cord Injury - Hua Yang; Pengwei Zhang; Min Xie; Jianxian Luo; Jing Zhang; Guowei Zhang; Yang Wang; Hongsheng Lin; Zhisheng Ji (Journal of Molecular Neuroscience, 2022)
Loss of physical and emotional health due to spinal cord injury (SCI) has been rapidly increasing worldwide. Effective evaluation of the severity of SCI is crucial to its prognosis. Herein, we constructed rat models of SCI with four different degrees of injury (sham group, light injury group, moderate injury group, and heavy injury group), using the surgical approach. Cerebrospinal fluid (CSF), plasma, and spinal cord were sampled at the sub-acute spinal cord (72 h post-injury) from each rat. The LC–MS-based metabolic profiling of these samples was performed according to a universal metabolome standard (UMS). The results demonstrated that 130, 104, and 128 metabolites were significantly altered within the CSF, plasma, and spinal cord samples, respectively. Among them, there were four differential metabolites, including uric acid, phosphorycholine, pyridoxine, and guanidoacetic acid, which were commonly identified within the CSF, plasma, and spinal cord samples. Further pathway analysis of these differential metabolites demonstrated a disturbance in the metabolism of glyoxylate and dicarboxylate and glycine, serine, and threonine which were associated with pathophysiologic consequence of spinal cord injury. In particular, phosphorycholine, pyridoxine, and guanidoacetic acid demonstrated a relationship with SCI severity. Thus, they could be utilized as potential metabolite biomarkers for SCI severity assessment.

Characterizing the Role of Glutamine synthetase Gene on Ammonia Nitrogen Detoxification Metabolism of the Razor Clam Sinonovacula constricta - Gaigai Sun; Changsen Sun; Jing He; Hanhan Yao; Wenfang Dai; Zhihua Lin; Yinghui Dong (Frontiers in Marine Science, 2021)
Ammonia nitrogen is a common toxic substance in the aquatic system, which seriously threatens the survival and growth of clams. However, less is known about the ammonia metabolism and detoxification strategy in razor clam. In this study, the polymorphism of the Glutamine synthetase gene from Sinonovacula constricta ( Sc-GS ) was found to be related to ammonia tolerance. By comparing the coding sequence (CDS) region of Sc-GS from two geographical populations, a total of 14 and 12 single nucleotide polymorphisms (SNPs) were identified, respectively, of which 10 loci were shared between the two populations. Among them, the locus c.1133T > G exhibited an extremely significant and strong association with ammonia tolerance in both populations ( P < 0.01), and it was missense mutation, which led to the amino acid change from leucine (Leu) to arginine (Arg). Furthermore, the results about H&E staining and immunohistochemistry of Sc-GS protein in gills and hepatopancreas revealed that it was specifically localized in the lateral cilia of gill filaments and the endothelial cells of hepatocytes. After inhibiting the Sc-GS expression by RNA interference (RNAi) technology, the transcript levels of Sc-GS were extremely significantly downregulated at 24, 48, 72, and 96 h ( P < 0.01) in the hepatopancreas. Taken together, these results indicated that the Sc-GS gene may participate in ammonia metabolism. In addition, these results will help to demonstrate the role of Sc-GS in ammonia nitrogen metabolism and provide markers related to ammonia nitrogen tolerance for molecular marker-assisted selection (MAS) of the razor clam.

210Po-210Pb Disequilibrium in the Western North Pacific Ocean: Particle Cycling and POC Export - Qiangqiang Zhong; Tao Yu; Hui Lin; Jing Lin; Jianda Ji; Jialin Ni; Jinzhou Du; Dekun Huang (Frontiers in Marine Science, 2021)
Estimating the particulate organic carbon (POC) export flux from the upper ocean is fundamental for understanding the efficiency of the biological carbon pump driven by sinking particles in the oceans. The downward POC flux from the surface ocean based on 210 Po- 210 Pb disequilibria in seawater samples from the western North Pacific Ocean (w-NPO) was measured in the early summer (May-June) of 2018. All the profiles showed a large 210 Po deficiency relative to 210 Pb in the euphotic zone (0–150 m), while this 210 Po deficiency vanished below ∼500 m (with 210 Po/ 210 Pb ∼1 or > 1). A one-dimensional steady-state irreversible scavenging model was used to quantify the scavenging and removal fluxes of 210 Po and 210 Pb in the euphotic zone of the w-NPO. In the upper ocean (0–150 m), dissolved 210 Po (D-Po) was scavenged into particles with a residence time of 0.6–5.5 year, and the 210 Po export flux out of the euphotic zone was estimated as (0.33–3.49) × 10 4 dpm/m 2 /year, resulting in a wide range of particulate 210 Po (P-Po) residence times (83–921 days). However, in the deep ocean (150–1,000 m), 210 Po was transferred from the particulate phase to the dissolved phase. Using an integrated POC inventory and the P-Po residence times (Eppley model) in the w-NPO euphotic zone, the POC export fluxes (mmol C/m 2 /d) varied from 0.6 ± 0.2 to 8.8 ± 0.4. In comparison, applying the POC/ 210 Po ratio of all (>0.45 μm) particles to 210 Po export flux (Buesseler model), the obtained POC export fluxes (mmol C/m 2 /d) ranged from 0.7 ± 0.1 to 8.6 ± 0.8. Both Buesseler and Eppley methods showed enhanced POC export fluxes at stations near the continental shelf (i.e., Luzon Strait and the Oyashio-Kuroshio mixing region). The Eppley model-based 210 Po-derived POC fluxes agreed well with the Buesseler model-based fluxes, indicating that both models are suitable for assessing POC fluxes in the w-NPO. The POC export efficiency was < 15%, suggesting a moderate biological carbon pump efficiency in the w-NPO. These low export efficiencies may be associated with the dominance of smaller particles and the processes of degradation and subsequent remineralization of these small particles in the euphotic zone of oligotrophic regions in the w-NPO.

Evolutionary characteristics and phylogeny of cotton chloroplast tRNAs - Ning Wang; Wan-Lin Dong; Xiao-Jing Zhang; Tong Zhou; Xiao-Juan Huang; Bao-Guo Li; Jian-Ni Liu; Xiong-Feng Ma; Zhong-Hu Li (Planta, 2021)

LncRNA XIST knockdown alleviates LPS-induced acute lung injury by inactivation of XIST/miR-132-3p/MAPK14 pathway - Chen Li; Jian-Hua Liu; Jing Su; Wei-Jia Lin; Jian-Qing Zhao; Zhi-Hua Zhang; Qi Wu (Molecular and Cellular Biochemistry, 2021)

Measuring Heterogeneity in 18F-Fluorodeoxyglucose Positron Emission Tomography Images for Classifying Metastatic and Benign Bone Lesions in Patients with Cervical Cancer - Feng-Yuan Liu; Gigin Lin; Jing-Ren Tseng; Angel Chao; Huei-Jean Huang; Hung-Hsueh Chou; Yu-Chen Chang; Tzu-Chen Yen; Chyong-Huey Lai (Journal of Medical and Biological Engineering, 2021)
Purpose Heterogeneity assessment can be applied for medical imaging analysis. Here, we evaluated first-order and texture analysis (TA) metrics in 18 F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography (PET) imaging for classification of metastatic and benign bone lesions in patients with cervical cancer. Methods The data of 18 F-FDG PET studies performed on a specific PET/CT system from 2016 to 2018 in patients with cervical cancer were retrieved. The data of bone lesions extracted from studies over 2016–2017 and 2018 were used as training and validation datasets, respectively. Metastatic bone lesions were identified in each dataset, with an equal number of benign bone lesions selected. Cuboid volume of interest (VOI) consisting of 3 × 3 × 5 reconstructed voxels was applied for first-order metrics, and cubic VOI consisting of smaller voxels with trilinear interpolation of standardized uptake value (SUV) was adopted for TA metrics. First-order metrics included the maximum SUV (SUVmax) of lesions and the mean voxel SUV and its standard deviation (SUVsd), skewness, and kurtosis in VOI. In total, 4464 TA metrics based on 62 texture features were evaluated. Logistic regression was used for classification with area under the receiver operating characteristic curve (AUC) as the performance measure. Results From the training and validation datasets, 98 and 42 metastatic bone lesions were identified, respectively. SUVsd demonstrated higher performance than did SUVmax in both the training (AUC .798 vs .732, P = .001) and validation (AUC .786 vs .684, P < .001) datasets. Top-performing TA metrics demonstrated significantly higher performance in the training dataset, but not in the validation dataset. Conclusion A simple first-order measure of heterogeneity, SUVsd, was found to be superior to SUVmax for the classification of metastatic and benign bone lesions. Multiple hypothesis testing can result in false-positive findings in TA with multiple features and parameters; careful validation is required.

LncRNA-SNHG16 promotes proliferation and migration of acute myeloid leukemia cells via PTEN/PI3K/AKT axis through suppressing CELF2 protein - Min Shi; Ruili Yang; Jing Lin; Qi Wei; Lei Chen; Weifeng Gong; Yang Li; Xiaobo Guo (Journal of Biosciences, 2021)

External evaluation of published population pharmacokinetic models of polymyxin B - Ya-qian Li; Kai-feng Chen; Jun-jie Ding; Hong-yi Tan; Nan Yang; Ya-qi Lin; Cui-fang Wu; Yue-liang Xie; Guo-ping Yang; Jing-Jing Liu; Qi Pei (European Journal of Clinical Pharmacology, 2021)

Is food production vulnerable to environmental degradation? A global analysis - Suet-Ling Ching; Kwang-Jing Yii; Cheong-Fatt Ng; Chee-Keong Choong; Lin-Sea Lau (Environmental and Ecological Statistics, 2021)

Interception, degradation and contributions of terrestrial organic carbon obtained from lignin analysis in Wujiang River, southwest China - Xin Lin; Yujie Wang; Jinhua Zhang; Ming Yang; Xueping Chen; Fushun Wang; Jing Ma (Acta Geochimica, 2021)

Antibiotic intervention redisposes bacterial interspecific interacting dynamics in competitive environments - Jing Li; Xiaojie Chen; Jiafu Lin; Yang Yuan; Ting Huang; Lianming Du; Balakrishnan Prithiviraj; Aixue Zhang; Xinrong Wang; Yiwen Chu; Kelei Zhao (Environmental Microbiology, 2021)
Summary Interspecific interaction happens frequently among bacterial species and can promote the colonization of polymicrobial community in various environments. However, it is not clear whether the intervention of antibiotics, which is a common therapeutic method for infectious disease, will influence the interacting dynamics of different pathogenic bacteria. By using the frequently co‐isolated bacteria Pseudomonas aeruginosa and Staphylococcus aureus as models, here we identify an antibiotic‐determined mutual invasion relationship between bacterial pathogens. We show that although P . aeruginosa has a significant intrinsic competitive advantage over S . aureus by producing the quorum‐sensing (QS)‐controlled anti‐staphylococcal molecules, methicillin‐resistant S . aureus (MRSA) can inhibit neighbouring P . aeruginosa in the presence of subinhibitory aminoglycoside antibiotics (e.g. streptomycin) to P . aeruginosa . Importantly, subinhibitory streptomycin decreases the expression of QS‐regulated genes in P . aeruginosa and thus relieves the survival stress of MRSA brought by P . aeruginosa . On the other side, the iron‐uptake systems and pathogenicity of MRSA can be enhanced by the extracellular products of streptomycin‐treated P . aeruginosa . Therefore, this study provides an explanation for the substitution of dominant species and persistent coexistence of bacterial pathogens in the host with repeated antibiotic therapies and contributes to further understanding the pathogenesis of chronic polymicrobial infections.

Two new diterpenoids with their antiproliferative activities from the supercritical fluid extraction of Croton crassifolius root - Chao Liu; Rui-rui Zhang; Qing-lin Niu; Jing Zhang; Mu-xuan Wang; Na-na Meng; Qing Wang; Jin-yue Sun; Wen-liang Wang (Natural Product Research, 2021)

Phenolic glycosides and flavonoids with antioxidant and anticancer activities from Desmodium caudatum - Qian-Nan Xu; Dan Zhu; Guang-Hui Wang; Ting Lin; Cui-Ling Sun; Rong Ding; Wen-Jing Tian; Hai-Feng Chen (Natural Product Research, 2021)

Chemical constituents from the barks of Melia azedarach and their PTP1B inhibitory activity - Sheng-Nan Zhang; Lin Huang; Rui-Jing Ma; Mei-Feng Yang; Ben-Fu Wei; Hong-Zhi Song; Heng-Shan Wang; Qin-Gang Tan (Natural Product Research, 2021)

Evaluation of the antifungal activity of Lysurus mokusin extract against Pestalotiopsis neglecta and GC–MS analysis of the active components - Lian-Nan Lin; Jing Yang; Guo-Cai Zhang; Xiao-Bo Zhang; Ting-Yu Wang; De-Dong Wu (Journal of Plant Pathology, 2021)

The role of mechanical harvesting on the recession of aquatic vegetation under an extreme water level increase in a eutrophic shallow lake - Changtao Yang; Jing Nan; Jianhua Li; Yi Lin; Jie Yu; Jianbin Wu; Xiaobing Shen (Environmental Science and Pollution Research, 2021)

Paternal exposure to microcystin-LR induces fetal growth restriction partially through inhibiting cell proliferation and vascular development in placental labyrinth - Lan Gao; An-Qi Cui; Jing Wang; Jing Chen; Xiao-Yi Zhang; Zhi-Jing Lin; Yuan-Hua Chen; Cheng Zhang; Hua Wang; De-Xiang Xu (Environmental Science and Pollution Research, 2021)

Frequent central Pacific La Niña events may accelerate Arctic warming since the 1980s - Jing Li; Lin Mu; Linhao Zhong (Acta Oceanologica Sinica, 2021)

Characteristics of Ichthyoplankton Communities and Their Relationship With Environmental Factors Above the Ninety East Ridge, Eastern Indian Ocean - Liyan Zhang; Jing Zhang; Shigang Liu; Rui Wang; Jiali Xiang; Xing Miao; Ran Zhang; Puqing Song; Longshan Lin (Frontiers in Marine Science, 2021)
The Ninety East Ridge is a submarine north–south oriented volcanic ridge in the eastern Indian Ocean. Surface-layer ichthyoplankton collected in this area from September to October were identified by combined morphological and molecular (DNA barcoding) techniques, and their species composition, diversity, and abundance, and correlations with environmental variables were described. Collections comprised 109 larvae and 507 eggs, which were identified to 37 taxa in 7 orders, 20 families, and 27 genera, and were dominated by the order Perciformes and species Vinciguerria sp., Oxyporhamphus micropterus , and Decapterus macarellus . Species abundances at each station and of each species were relatively low, suggesting that this area or the time of sampling were not of major importance for fish spawning. Waters above Ninety East Ridge had lower species diversity but higher species richness than waters further offshore. A generalized additive model revealed that high abundance of ichthyoplanktonic taxa occurred in areas with low sea surface height and high sea surface salinity, temperature, and chlorophyll a concentration. Of these, sea surface height was most correlated with ichthyoplankton abundance. We provided baseline data on surface-dwelling ichthyoplankton communities in this area to aid in development of pelagic fishery resources in waters around the Ninety East Ridge.

Two new cephalochromin derivative from the Alternaria sp. ZG22 - Xin-Ming Song; Xue-Ming Zhou; Ya-Ling Li; Li-Bing Huang; Cai-Cui Chen; Yan Gao; Lin He; Xiao-qun Mao; Bing Chen; Jing-Wen Liu; Hui-Jie Liu; Xiao-Ping Song; et al. (Natural Product Research, 2021)

How do different nitrogen application levels and irrigation practices impact biological nitrogen fixation and its distribution in paddy system? - Yanhui Zhang; Tianlong Hu; Hui Wang; Haiyang Jin; Qi Liu; Zhibin Lin; Benjuan Liu; Hongtao Liu; Zhe Chen; Xinwu Lin; Xiaojie Wang; Jing Ma; et al. (Plant and Soil, 2021)

Tree growth response to soil nutrients and neighborhood crowding varies between mycorrhizal types in an old-growth temperate forest - Jing Ren; Shuai Fang; Guigang Lin; Fei Lin; Zuoqiang Yuan; Ji Ye; Xugao Wang; Zhanqing Hao; Claire Fortunel (Oecologia, 2021)

The Decision Strategies of Adolescents with Different Emotional Stabilities in Unfair Situations - Yajing Si; Lin Jiang; Chanlin Yi; Qi Zhang; Cunbo Li; Jing Yu; Peiyang Li; Qiang Liu; Feng Wan; Fali Li; Dezhong Yao; Peng Xu (Neuroscience Bulletin, 2021)

Complement C3 Aggravates Post-epileptic Neuronal Injury Via Activation of TRPV1 - Guang-Tong Jiang; Lin Shao; Shuo Kong; Meng-Liu Zeng; Jing-Jing Cheng; Tao-Xiang Chen; Song Han; Jun Yin; Wan-Hong Liu; Xiao-Hua He; Yu-Min Liu; Lanzi Gongga; et al. (Neuroscience Bulletin, 2021)

Chronic Exposure to Hypoxia Inhibits Myelinogenesis and Causes Motor Coordination Deficits in Adult Mice - Lin Chen; Shu-Yu Ren; Rui-Xue Li; Kun Liu; Jing-Fei Chen; Yu-Jian Yang; Yong-Bin Deng; Han-Zhi Wang; Lan Xiao; Feng Mei; Fei Wang (Neuroscience Bulletin, 2021)
Exposure to chronic hypoxia is considered to be a risk factor for deficits in brain function in adults, but the underlying mechanisms remain largely unknown. Since active myelinogenesis persists in the adult central nervous system, here we aimed to investigate the impact of chronic hypoxia on myelination and the related functional consequences in adult mice. Using a transgenic approach to label newly-generated myelin sheaths ( NG2-CreER TM ; Tau-mGFP ), we found that myelinogenesis was highly active in most brain regions, such as the motor cortex and corpus callosum. After exposure to hypoxia (10% oxygen) 12 h per day for 4 weeks, myelinogenesis was largely inhibited in the 4-month old brain and the mice displayed motor coordination deficits revealed by the beam-walking test. To determine the relationship between the inhibited myelination and functional impairment, we induced oligodendroglia-specific deletion of the transcription factor Olig2 by tamoxifen ( NG2-CreER TM ; Tau-mGFP; Olig2 fl/fl ) in adult mice to mimic the decreased myelinogenesis caused by hypoxia. The deletion of Olig2 inhibited myelinogenesis and consequently impaired motor coordination, suggesting that myelinogenesis is required for motor function in adult mice. To understand whether enhancing myelination could protect brain functions against hypoxia, we treated hypoxic mice with the myelination-enhancing drug-clemastine, which resulted in enhanced myelogenesis and improved motor coordination. Taken together, our data indicate that chronic hypoxia inhibits myelinogenesis and causes functional deficits in the brain and that enhancing myelinogenesis protects brain functions against hypoxia-related deficits.

Circ_0020093 ameliorates IL-1β-induced apoptosis and extracellular matrix degradation of human chondrocytes by upregulating SPRY1 via targeting miR-23b - Mingli Feng; Lin Jing; Jingbo Cheng; Shuai An; Jiang Huang; Qi Yan (Molecular and Cellular Biochemistry, 2021)
Osteoarthritis (OA) is a chronic disease characterized by articular cartilage degeneration and uncontrolled chondrocyte apoptosis. At present, accumulating evidence introduces that circular RNA (circRNA) is involved in the development of OA. The aim of our study was to explore the role and the functional mechanism of circ_0020093 in OA cell model. Human chondrocytes were treated with interleukin-1 beta (IL-1β) to construct OA model. The expression of circ_0020093, miR-23b, and Sprouty 1 (SPRY1) mRNA was measured by quantitative real-time polymerase chain reaction (qRT-PCR). Cell apoptosis was assessed by flow cytometry assay. The expression of extracellular matrix (ECM)-associated markers and SPRY1 protein level was detected by qRT-PCR and Western blot. Bioinformatics analysis-predicted relationship between miR-23b and circ_0020093 or SPRY1 was further verified by dual-luciferase reporter assay and RNA pull-down assay. In this study, we found that the expression of circ_0020093 and SPRY1 was declined, while miR-23b expression was elevated in IL-1β-treated chondrocytes. IL-1β induced chondrocyte apoptosis and ECM degradation, while these negative effects were alleviated by circ_0020093 overexpression or miR-23b inhibition. MiR-23b was a target of circ_0020093, and SPRY1 was a downstream target of miR-23b. Rescue experiments showed that miR-23b enrichment reversed the role of circ_0020093 overexpression, and SPRY1 knockdown also reversed the effects of miR-23b inhibition. Importantly, circ_0020093 positively regulated SPRY1 expression by targeting miR-23b. In conclusion, circ_0020093 ameliorates IL-1β-induced apoptosis and ECM degradation of human chondrocytes by regulating the miR-23b/SPRY1 axis.

SMRT sequencing of full-length transcriptome of birch-leaf pear (Pyrus betulifolia Bunge) under drought stress - Qingsong Yang; Jinxing Wang; Zhonghua Wang; Xiaogang Li; Jialiang Kan; Jing Lin (Journal of Genetics, 2021)

Exercise renovates H2S and Nrf2-related antioxidant pathways to suppress apoptosis in the natural ageing process of male rat cortex - Jing-Ying Lin; Tsung-Jung Ho; Bruce Chi-Kang Tsai; Chien-Yi Chiang; Hui-Chuan Kao; Wei-Wen Kuo; Ray-Jade Chen; Vijaya Padma Viswanadha; Chi-Wen Huang; Chih-Yang Huang (Biogerontology, 2021)

Experimental study on integrated and autonomous conductivity-temperature-depth (CTD) sensor applied for underwater glider - Bin Lv; Hai-lin Liu; Yi-fan Hu; Cheng-xuan Wu; Jie Liu; Hai-jing He; Jie Chen; Jian Yuan; Zhao-wen Zhang; Lin Cao; Hui Li (Marine Georesources & Geotechnology, 2021)

Plant multiscale networks: charting plant connectivity by multi-level analysis and imaging techniques - Xi Zhang; Yi Man; Xiaohong Zhuang; Jinbo Shen; Yi Zhang; Yaning Cui; Meng Yu; Jingjing Xing; Guangchao Wang; Na Lian; Zijian Hu; Lingyu Ma; et al. (Science China Life Sciences, 2021)

Descending Modulation of Spinal Itch Transmission by Primary Somatosensory Cortex - Zi-Han Wu; Han-Yu Shao; Yuan-Yuan Fu; Xiao-Bo Wu; De-Li Cao; Sheng-Xiang Yan; Wei-Lin Sha; Yong-Jing Gao; Zhi-Jun Zhang (Neuroscience Bulletin, 2021)

Comparison of pramipexole and levodopa/benserazide combination therapy versus levodopa/benserazide monotherapy in the treatment of Parkinson’s disease: a systematic review and meta-analysis - De-Qi Jiang; Qing-Min Zang; Li-Lin Jiang; Yan Wang; Ming-Xing Li; Jing-Yi Qiao (Naunyn-Schmiedeberg's Archives of Pharmacology, 2021)

Deficiency of Klc2 Induces Low-Frequency Sensorineural Hearing Loss in C57BL/6 J Mice and Human - Xiaolong Fu; Yachun An; Hongyang Wang; Peipei Li; Jing Lin; Jia Yuan; Rongyu Yue; Yecheng Jin; Jiangang Gao; Renjie Chai (Molecular Neurobiology, 2021)

Acute associations between air pollution on premature rupture of membranes in Hefei, China - Chao Zhang; Sha Li; Gan-lan Guo; Jing-wen Hao; Peng Cheng; Li-lin Xiong; Shu-ting Chen; Ji-yu Cao; Yu-wen Guo; Jia-hu Hao (Environmental Geochemistry and Health, 2021)

Taxonomic description of Pseudomonas rhizovicinus sp. nov., isolated from the rhizosphere of a desert shrub Haloxylon ammodendron - Ao-Lei He; Hui-Ru Li; Hui-Ping Li; Jing-Yi Gou; Jia Chen; Qi Zhao; Jin-Lin Zhang (Antonie van Leeuwenhoek, 2021)

Evaluation and improvement of the greenness of plasma spraying through life cycle assessment and grey relational analysis - Jing Liu; Liming Wang; Fangyi Li; Yanle Li; Xueju Ran; Lin Kong; Yan Fu (The International Journal of Life Cycle Assessment, 2021)

Possible pharmaceutical applications can be developed from naturally occurring phenanthroindolizidine and phenanthroquinolizidine alkaloids - Xian-hui Jia; Huan-xin Zhao; Cheng-lin Du; Wen-zhao Tang; Xiao-jing Wang (Phytochemistry Reviews, 2021)

Dicer Deletion in Astrocytes Inhibits Oligodendroglial Differentiation and Myelination - Kun Liu; Bin Yu; Jing-Fei Chen; Rui-Xue Li; Lin Chen; Shu-Yu Ren; Fei Wang; Feng Mei; Lan Xiao (Neuroscience Bulletin, 2021)
Increasing evidence has shown that astrocytes are implicated in regulating oligodendrocyte myelination, but the underlying mechanisms remain largely unknown. To understand whether microRNAs in astrocytes function in regulating oligodendroglial differentiation and myelination in the developing and adult CNS, we generated inducible astrocyte-specific Dicer conditional knockout mice (hGFAP-CreERT; Dicer fl/fl). By using a reporter mouse line (mT/mG), we confirmed that hGFAP-CreERT drives an efficient and astrocyte-specific recombination in the developing CNS, upon tamoxifen treatment from postnatal day 3 (P3) to P7. The Dicer deletion in astrocytes resulted in inhibited oligodendroglial differentiation and myelination in the developing CNS of Dicer cKO mice at P10 and P14, and did not alter the densities of neurons or axons, indicating that Dicer in astrocytes is required for oligodendrocyte myelination. Consequently, the Dicer deletion in astrocytes at P3 resulted in impaired spatial memory and motor coordination at the age of 9 weeks. To understand whether Dicer in astrocytes is also required for remyelination, we induced Dicer deletion in 3-month-old mice and then injected lysolecithin into the corpus callosum to induce demyelination. The Dicer deletion in astrocytes blocked remyelination in the corpus callosum 14 days after induced demyelination. Together, our results indicate that Dicer in astrocytes is required for oligodendroglia myelination in both the developing and adult CNS.

A New Approach to Model Sporadic Alzheimer’s Disease by Intracerebroventricular Streptozotocin Injection in APP/PS1 Mice - Sally Kelliny; Liying Lin; Isaac Deng; Jing Xiong; Fiona Zhou; Mohammed Al-Hawwas; Larisa Bobrovskaya; Xin-Fu Zhou (Molecular Neurobiology, 2021)

Patient Confidential Information Transmission Using the Integration of PSO-Based Biomedical Signal Steganography and Threshold-Based Compression - Shih-Ying Chen; Shan-Ju Lin; Ming-Cheng Tsai; Ming-Dar Tsai; Yih-Jing Tang; Shuo-Tsung Chen; Li-Hsiang Wang (Journal of Medical and Biological Engineering, 2021)

Conversion of rice husk into fermentable sugar and silica using acid-catalyzed ionic liquid pretreatment - YuJie Wang; Jing-yong Liu; Jian Sun; Sumarlin Shangdiar; Kassian T.T. Amesho; Yung-Chang Lin; Yen-Ping Peng; Ken-Lin Chang (Environmental Science and Pollution Research, 2021)

Interaction between β-lactam antibiotic and phosphorus-accumulating organisms - Rong Huang; Jing Lan; Chaoguo Zhan; Yanhui Ge; Lin Zhao (Environmental Science and Pollution Research, 2021)

Whole brain volume and cortical thickness abnormalities in Wilson’s disease: a clinical correlation study - Yukun Song; Lin Zou; Jing Zhao; Xiangxue Zhou; Yingqian Huang; Haishan Qiu; Haiwei Han; Zhiyun Yang; Xunhua Li; Xiaoying Tang; Jianping Chu (Brain Imaging and Behavior, 2021)

Glabridin attenuates atopic dermatitis progression through downregulating the TLR4/MyD88/NF-κB signaling pathway - Jing Chang; Lin Wang; Minna Zhang; Zengjiao Lai (Genes & Genomics, 2021)

Porcine circovirus type 2 (PCV2) infection in Hebei Province from 2016 to 2019: a retrospective study - Lei Han; Guang-fu Yuan; Shao-jie Chen; Fei Dai; Lin-shan Hou; Jing-hui Fan; Yu-zhu Zuo (Archives of Virology, 2021)

Spatiotemporal analysis of temperature data trends in Peninsular Malaysia - Hun Vui Woo; Jing Lin Ng; Yuk Feng Huang; Celine Chong; Jin Chai Lee (Arabian Journal of Geosciences, 2021)

Effects of diethyl aminoethyl hexanoate on the physiology and selenium absorption of grape seedlings - Lei Liu; Jiaxi Han; Lili Deng; Huixuan Zhou; Yuhui Bie; Qianhe Jing; Lijin Lin; Jin Wang; Ming’an Liao (Acta Physiologiae Plantarum, 2021)

Strong in vitro and in vivo cytotoxic effects of two platinum(II) complexes with cryptolepine derivatives - Li-Qin Qin; Zu-Zhuang Wei; Lin Yang; Qi-Pin Qin; Jia-Jing Zeng; Ming-Xiong Tan; Hong Liang (Medicinal Chemistry Research, 2021)

Machine learning-based thermokarst landslide susceptibility modeling across the permafrost region on the Qinghai-Tibet Plateau - Guoan Yin; Jing Luo; Fujun Niu; Zhanju Lin; Minghao Liu (Landslides, 2021)

A luminescent Zn(II)-Containing Complex: Selective Sensing of Cr(VI) Anion and Application Values on Tuberculosis Care Through Increasing the Antibacterial Response of Macrophages - Jin-Chao Mao; Jin-Jing Hong; Ming-Zheng Lin; Feng Han; Dong Li (Journal of Fluorescence, 2021)

Discovery of a naturally-occurring allele of eIF4E1.S in Nicotiana tabacum and development of a co-dominant marker - Shifeng Lin; Ralph E. Dewey; Rengang Wang; Jing Yu; Mingjin Long; Jie Zhang; Shizhou Yu; Jishun Zhang; Zili Wang; Xueliang Ren (Euphytica, 2021)

Recurrence of wintertime SST anomalies in the Bay of Bengal: characteristics and causes - Yun Qiu; Xinyu Lin; Chunsheng Jing (Climate Dynamics, 2021)

The influence of surfactant on the wettability of coal dust and dust reduction efficiency - Lin Yang; Shaocheng Ge; Zhihui Huang; Deji Jing; Xi Chen (Arabian Journal of Geosciences, 2021)

Nanoemulgel for Improved Topical Delivery of Desonide: Formulation Design and Characterization - Qiuyan Ma; Jing Zhang; Bohong Lu; Huaqing Lin; Rajib Sarkar; Tao Wu; Xuee Li (AAPS PharmSciTech, 2021)

Above‐ and belowground biodiversity jointly drive ecosystem stability in natural alpine grasslands on the Tibetan Plateau - Litong Chen; Lin Jiang; Xin Jing; Jiuluan Wang; Yu Shi; Haiyan Chu; Jin‐Sheng He (Global Ecology and Biogeography, 2021)
Aim Most existing studies that examined the biotic mechanisms of ecosystem stability have focused on aboveground biodiversity. Whether and how belowground biodiversity affects the stability of natural ecosystems is largely unknown. In the present study, we investigated the relationships between above‐ and belowground biodiversity and the temporal stability of grassland biomass production across a large gradient of soil and climatic conditions. Location Tibetan Plateau. Time period 2001–2016. Major taxa studied Alpine grass and soil bacteria, arbuscular mycorrhiza (AM) fungi and fauna. Methods We coupled a field biodiversity survey conducted in 54 alpine grassland ecosystems across the Tibetan Plateau with a satellite‐sensed proxy (enhanced vegetation index, EVI) of ecosystem productivity during 2001–2016. The temporal stability of primary productivity was calculated as the ratio of the mean annual peak EVI to the standard deviation of the annual peak EVI over this period. Plant diversity was determined using a classic vegetation survey approach, soil bacterial and AM fungal diversity were measured using a high‐throughput sequencing approach, and soil fauna was counted and identified at the order level after being extracted using a modified Berlese–Tullgren method. Results Our results demonstrated that both above‐ and belowground biodiversity were positively associated with ecosystem stability. Belowground biodiversity not only affected ecosystem stability directly, but also influenced it indirectly through plant diversity and soil fertility. Furthermore, soil pH, climate and its variability strongly influenced soil biodiversity, which in turn influenced ecosystem stability. Main conclusions Our study demonstrates the indispensable role of belowground biodiversity in regulating ecosystem stability, emphasizing the necessity of conserving this ‘hidden’ biodiversity in fragile alpine ecosystems facing ongoing environmental change.

Soil Bacterial Characteristics Under Four Habitats with Different Vegetation Communities on the Qinghai-Tibetan Plateau - Rui Wang; Miao Wang; Jing Wang; Jiahe Yao; Xinwei Li; Yinghua Lin; Fang K. Du (Wetlands, 2021)

Long non-coding RNA NEAT1 promotes lipopolysaccharide-induced injury in human tubule epithelial cells by regulating miR-93-5p/TXNIP axis - Jing Yang; Lin Wu; Shanshou Liu; Xiaomin Hu; Qianmei Wang; Liying Fang (Medical Microbiology and Immunology, 2021)

Safety and efficacy of new oral anticoagulants compared to those of warfarin in AF patients with cancer: a meta-analysis of randomized clinical trials and observational studies - Yueming Chen; Min Mao; Jing Chang; Jing Yan; Tiantian Yang; Yang Liu; Meng Luo; Yuhao Hu; Qi Yang; Lin Zhou; Kanghua Ma (European Journal of Clinical Pharmacology, 2021)

Correction to: Synthetic antimicrobial agents inhibit aflatoxin production - Jing Li; Qing-Qing Zhi; Jie Zhang; Xiao-Yu Yuan; Li-Hong Jia; Yu-Lin Wan; Qiu-Yun Liu; Jian-Rong Shi; Zhu-Mei He (Brazilian Journal of Microbiology, 2021)

Synthetic antimicrobial agents inhibit aflatoxin production - Jing Li; Qing-Qing Zhi; Jie Zhang; Xiao-Yu Yuan; Li-Hong Jia; Yu-Lin Wan; Qiu-Yun Liu; Jian-Rong Shi; Zhu-Mei He (Brazilian Journal of Microbiology, 2021)

A dye combination for the staining of pollen coat and pollen wall - Xin-Lei Jia; Jing-Shi Xue; Fang Zhang; Chi Yao; Shi-Yi Shen; Chang-Xu Sui; Yu-Jia Peng; Qin-Lin Xu; Yi-Feng Feng; Wen-Jing Hu; Ping Xu; Zhong-Nan Yang (Plant Reproduction, 2021)

An Improved DDV Algorithm for the Retrieval of Aerosol Optical Depth From NOAA/AVHRR Data - Ruibo Li; Lin Sun; Huiyong Yu; Jing Wei; Xinpeng Tian (Journal of the Indian Society of Remote Sensing, 2021)

Cryostructures and ground ice content in ice-rich permafrost area of the Qinghai-Tibet Plateau with Computed Tomography Scanning - Xing-wen Fan; Zhan-ju Lin; Ze-yong Gao; Xiang-lian Meng; Fu-jun Niu; Jing Luo; Guo-an Yin; Fu-jun Zhou; Ai-yu Lan (Journal of Mountain Science, 2021)

Defense responses of sulfur dioxygenase to sulfide stress in the razor clam Sinonovacula constricta - Caifang Chen; Yaoyao Shen; Weiliang Shen; Jing He; Zhihua Lin; Yinghui Dong (Genes & Genomics, 2021)

Prediction of oral hepatotoxic dose of natural products derived from traditional Chinese medicines based on SVM classifier and PBPK modeling - Size Li; Yiqun Yu; Xiaolan Bian; Li Yao; Min Li; Yan-Ru Lou; Jing Yuan; Hai-shu Lin; Lucy Liu; Bing Han; Xiaoqiang Xiang (Archives of Toxicology, 2021)

Rosanortriterpenes A–B, two new nortriterpenes from the fruits of Rosa laevigata var. leiocapus - Yu-Nong Tian; Bai-Lin Li; Juan-Juan Hu; Jin-Dan Xie; Wen-Jing Xiao; Ling-Hui Nie; Jie-Wei Wu (Natural Product Research, 2021)

Application of a dissolved oxygen control strategy to increase the expression of Streptococcus suis glutamate dehydrogenase in Escherichia coli - Likun Cheng; Chunguang Zhao; Xiuyan Yang; Zheng Song; Chuwen Lin; Xiubao Zhao; Jinliang Wang; Jing Wang; Lei Wang; Xiaojing Xia; Zhiqiang Shen (World Journal of Microbiology and Biotechnology, 2021)

TLR8 in the Trigeminal Ganglion Contributes to the Maintenance of Trigeminal Neuropathic Pain in Mice - Lin-Xia Zhao; Ming Jiang; Xue-Qiang Bai; De-Li Cao; Xiao-Bo Wu; Jing Zhang; Jian-Shuang Guo; Tong-Tong Chen; Juan Wang; Hao Wu; Yong-Jing Gao; Zhi-Jun Zhang (Neuroscience Bulletin, 2021)
Trigeminal neuropathic pain (TNP) is a significant health problem but the involved mechanism has not been completely elucidated. Toll-like receptors (TLRs) have recently been demonstrated to be expressed in the dorsal root ganglion and involved in chronic pain. Here, we show that TLR8 was persistently increased in the trigeminal ganglion (TG) neurons in model of TNP induced by partial infraorbital nerve ligation (pIONL). In addition, deletion or knockdown of Tlr8 in the TG attenuated pIONL-induced mechanical allodynia, reduced the activation of ERK and p38-MAPK, and decreased the expression of pro-inflammatory cytokines in the TG. Furthermore, intra-TG injection of the TLR8 agonist VTX-2337 induced pain hypersensitivity. VTX-2337 also increased the intracellular Ca 2+ concentration, induced the activation of ERK and p38, and increased the expression of pro-inflammatory cytokines in the TG. These data indicate that TLR8 contributes to the maintenance of TNP through increasing MAPK-mediated neuroinflammation. Targeting TLR8 signaling may be effective for the treatment of TNP.

The effect of cyfluthrin on testis inhibin B in rats and the intervention of Lycium barbarum polysaccharide - Xin Guo; Yong-Xin Xie; Chen Guo; Jing-Lin Wei; Hui-Fang Yang (Molecular & Cellular Toxicology, 2021)

Molecular mechanism underlying Pyropia haitanensis PhHsp22-mediated increase in the high-temperature tolerance of Chlamydomonas reinhardtii - Jing Chang; Jianzhi Shi; Jianzhang Lin; Dehua Ji; Yan Xu; Changsheng Chen; Wenlei Wang; Chaotian Xie (Journal of Applied Phycology, 2021)
Global warming is one of the key limiting factors affecting the cultivation of Pyropia haitanensis which is an economically important macroalgae species grown in southern China. However, the mechanism underlying the high-temperature tolerance of P. haitanensis remains largely unknown. In a previous study, we showed that the expression of the small heat shock protein 22 gene ( Hsp22 ) is upregulated in P. haitanensis in response to high-temperature stress, but the associated regulatory mechanism was not fully elucidated. In this study, a transgenic Chlamydomonas reinhardtii expression system was used to functionally characterize P. haitanensis Hsp22 . Our analyses indicated that the C-terminal of PhHsp22 is highly conserved and contains an A-crystal structure domain. A phylogenetic analysis revealed PhHsp22 is not closely related to small heat shock protein genes in other species. Additionally, PhHsp22 expression significantly increased at 3 and 6 h after initiating 33 °C treatment, which improved the survival rate of transgenic C. reinhardtii during the early stage of high-temperature treatment. The further transcriptome analysis revealed that PhHsp22 expression can promote pathways related to energy metabolism, metabolites metabolism, and protein homeostasis in transgenic C. reinhardtii cells exposed to high temperatures. Therefore, PhHsp22 may be crucial for the response of Pyropia species to high-temperature stress. Furthermore, this gene may be useful for breeding new high-temperature algal strains.

Microbiological profiles and antimicrobial resistance patterns of pediatric bloodstream pathogens in China, 2016–2018 - Yue Qiu; Junwen Yang; Yiping Chen; Jinhong Yang; Qingxiong Zhu; Chunhui Zhu; Shuangjie Li; Jing Liu; Chaomin Wan; Yu Zhu; Minxia Chen; Yi Xu; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Population-based meta-analysis of chloroquine: informing chloroquine pharmacokinetics in COVID-19 patients - Xueting Yao; Xiaoyu Yan; Xiaohan Wang; Ting Cai; Shun Zhang; Cheng Cui; Xiaoxu Wang; Zhe Hou; Qi Liu; Haiyan Li; Jing Lin; Zi Xiong; et al. (European Journal of Clinical Pharmacology, 2021)
Aims Chloroquine (CQ) has been repurposed to treat coronavirus disease 2019 (COVID-19). Understanding the pharmacokinetics (PK) in COVID-19 patients is essential to study its exposure–efficacy/safety relationship and provide a basis for a possible dosing regimen optimization. Subject and methods In this study, we used a population-based meta-analysis approach to develop a population PK model to characterize the CQ PK in COVID-19 patients. An open-label, single-center study (ethical review approval number: PJ-NBEY-KY-2020-063-01) was conducted to assess the safety, efficacy, and pharmacokinetics of CQ in patients with COVID-19. The sparse PK data from 50 COVID-19 patients, receiving 500 mg CQ phosphate twice daily for 7 days, were combined with additional CQ PK data from 18 publications. Results A two-compartment model with first-order oral absorption and first-order elimination and an absorption lag best described the data. Absorption rate (ka) was estimated to be 0.559 h −1 , and a lag time of absorption (ALAG) was estimated to be 0.149 h. Apparent clearance (CL/F) and apparent central volume of distribution (V2/F) was 33.3 l/h and 3630 l. Apparent distribution clearance (Q/F) and volume of distribution of peripheral compartment (Q3/F) were 58.7 l/h and 5120 l. The simulated CQ concentration under five dosing regimens of CQ phosphate were within the safety margin (400 ng/ml). Conclusion Model-based simulation using PK parameters from the COVID-19 patients shows that the concentrations under the currently recommended dosing regimen are below the safety margin for side-effects, which suggests that these dosing regimens are generally safe. The derived population PK model should allow for the assessment of pharmacokinetics–pharmacodynamics (PK-PD) relationships for CQ when given alone or in combination with other agents to treat COVID-19.

Establishment of a comprehensive analysis method for the microfaunal movement in activated sludge - Xiaobing Hu; Kun Wang; Jing Chang; Lin Zhang; Meiying Zhong; Yong Nie (Environmental Science and Pollution Research, 2021)

Comparative understanding of metal hyperaccumulation in plants: a mini-review - Jia-Shi Peng; Yu-Hao Guan; Xian-Jing Lin; Xiao-Jing Xu; Lu Xiao; Hai-Hua Wang; Shuan Meng (Environmental Geochemistry and Health, 2021)

Formation and driving factors of sulfate in PM2.5 at a high-level atmospheric SO2 city of Yangquan in China - Cheng Wang; Yulong Yan; Yueyuan Niu; Rumei Li; Yang Xu; Dongmei Hu; Jing Wu; Lin Peng (Air Quality, Atmosphere & Health, 2021)

Levels and patterns of genetic variation in Pampus minor: Assessment of a mitochondrial DNA control region sequence - Yuan Li; Liyan Zhang; Jing Zhang; Cheng Liu; Longshan Lin (Acta Oceanologica Sinica, 2021)

Correction to: Effect of Surface Property on the Release and Oral Absorption of Solid Sirolimus-Containing Self-Microemulsifying Drug Delivery System - Xueting Zhang; Zhenzhen Chen; Chun Tao; Jing Zhang; Minxin Zhang; Jialiang Zhang; Zhihong Liu; Jiao Lin; Hang Xu; Qian Zhang; Hongtao Song (AAPS PharmSciTech, 2021)

Effect of Surface Property on the Release and Oral Absorption of Solid Sirolimus-Containing Self-microemulsifying Drug Delivery System - Xueting Zhang; Zhenzhen Chen; Chun Tao; Jing Zhang; Minxin Zhang; Jialiang Zhang; Zhihong Liu; Jiao Lin; Hang Xu; Qian Zhang; Hongtao Song (AAPS PharmSciTech, 2021)

Environmental Effects on the Spatiotemporal Variability of Fish Larvae in the Western Guangdong Waters, China - Yuting Feng; Lijun Yao; Hui Zhao; Jing Yu; Zhaojin Lin (Journal of Marine Science and Engineering, 2021)
Spawning grounds occupy an important position in the survival and reproduction of aquatic life, which plays an important role in the replenishment of fishery resources, especially in the China coasts where fishery resources are depleting. This study investigated environmental effects on the spatiotemporal variability of fish larvae in the western Guangdong waters (WGWs), on the basis of generalized additive models (GAMs) and center of gravity (CoG). Satellite data including sea surface salinity (SSS), sea surface temperature (SST), and in situ observations for fish larvae from April to June in 2014–2015 were used. Results showed that 40.3% of the total variation in fish larvae density was explained. SST, SSS, and depth showed positive effects in 23–24 °C and 27–30 °C, 24–32 PSU, and 0–60 m, and showed negative effects in 24–27 °C, 32–34.2 PSU, 60–80 m. Based on the stepwise GAMs, the most important factor was month, with a contribution of 10.6%, followed by longitude, offshore distance, depth, and latitude, with contributions of 7.0%, 7.0%, 6.3%, 4.2%, 3.9%, and 1.3%, respectively. Fish larvae CoG shifted northward by 0.6° N and eastwards by 0.13° E from April to June. The distribution of fish larvae in the WGWs was affected by complex submarine topography in the Qiongzhou Strait, coastal upwelling in the WGWs, and runoff from the Pearl River.

CXCL10/CXCR3 Signaling in the DRG Exacerbates Neuropathic Pain in Mice - Yan-Fang Kong; Wei-Lin Sha; Xiao-Bo Wu; Lin-Xia Zhao; Ling-Jie Ma; Yong-Jing Gao (Neuroscience Bulletin, 2021)

Shallow gas hydrates off southwest Taiwan and their mechanisms - Yin-Sheng Huang; Shu-Kun Hsu; Chih-Chieh Su; Andrew Tien-Shun Lin; Pai-Sen Yu; Nathalie Babonneau; Gueorgui Ratzov; Serge Lallemand; Pi-Chuen Huang; Shiao-Shan Lin; Jing-Yi Lin; Kuo-Yen Wei; et al. (Marine Geophysical Research, 2021)
We have collected two shallow gas hydrate samples at two sites having different geological settings off southwest Taiwan during the cruise MD214 in 2018. The first core site, MD18-3542, is on the South Yuan-An East Ridge at ~ 1200 m water deep, where a structural unconformity covered by fine-silt sediments appears at ~ 5.5 m below the seafloor. The second core site, MD18-3543, is close to the Good-Weather Ridge at ~ 1100 m water deep, where a gas-related pockmark structure and authigenic carbonates are present at shallow strata with fine-silt sediments near the seafloor. Sediment properties of core MD18-3542 are distinctively different above and below the layer corresponding to the unconformity. Both cores show obvious gaps or voids in the lower core halves. The core features could be linked to the dissociated methane upward migrating from deep strata. Core site settings with upwelling methane would favor the formation of shallow gas hydrates. At site MD18-3542, the shallow hydrate could be formed due to high concentration methane kept beneath the unconformity covered by fine-silt sediments. At site MD18-3543, the shallow hydrate could be formed due to an extremely high flux of upwelling methane trapped either beneath the authigenic carbonates or fine-silt sediments.

Shear creep behavior of red sandstone after freeze-thaw cycles considering different temperature ranges - Dong Wang; Guoqing Chen; Dahua Jian; Jing Zhu; Zhiheng Lin (Bulletin of Engineering Geology and the Environment, 2021)

Effects of degradation succession of alpine wetland on soil organic carbon and total nitrogen in the Yellow River source zone, west China - Chun-ying Lin; Xi-lai Li; Jing Zhang; Hua-fang Sun; Juan Zhang; Hui-bang Han; Qi-hua Wang; Cheng-biao Ma; Cheng-yi Li; Yu-xing Zhang; Xue-qian Ma (Journal of Mountain Science, 2021)

First Detection and Molecular Identification of Entamoeba in Yaks from China - Mei Ren; Fan Yang; Jing-min Gou; Pin-xue Wang; Min Zou; Xiao-hong Zhong; Qing Lin (Acta Parasitologica, 2021)

Evaluation of reanalysis surface wind products with quality-assured buoy wind measurements along the north coast of the South China Sea - Jing Cha; Xinyu Lin; Xiaogang Guo; Xiaofang Wan; Dawei You (Acta Oceanologica Sinica, 2021)

Two new phthalide derivatives from the endophytic fungus Penicillium vulpinum isolated from Sophora tonkinensis - Yuyue Qin; Xiaobo Liu; Jing Lin; Jingying Huang; Xiaofei Jiang; Tuxiang Mo; Zhaolong Xu; Jun Li; Ruiyun Yang (Natural Product Research, 2021)

Influences of organic material application on the physically separated soil organic carbon and nitrogen fractions in rice fields - Qiaogang Yu; Jing Ye; Wanchun Sun; Hui Lin; Qiang Wang; Junwei Ma (Journal of Soils and Sediments, 2021)

Identification of contaminants as members of the Bacillus pumilus group and analysis of contamination sources in the cultivation of Pleurotus geesteranus mushrooms - Na Lu; Wei-Dong Yuan; You-Liang Wu; Ji-Ling Song; Lin Ma; Wei-Ke Wang; Jing Yan; Zai-Ming Chen; Qing Chen (Journal of Plant Pathology, 2021)

Macrophage ICAM-1 functions as a regulator of phagocytosis in LPS induced endotoxemia - Hanhui Zhong; Haitao Lin; Qiongni Pang; Jinling Zhuang; Xiaolei Liu; Xiaolian Li; Jinghua Liu; Jing Tang (Inflammation Research, 2021)

Suppression of HELLS by miR-451a represses mTOR pathway to hinder aggressiveness of SCLC - Jiyun Cui; Jing Wang; Yuyao Shen; Dianjie Lin (Genes & Genomics, 2021)

Seasonal analysis of artificial oyster reef ecosystems: implications for sustainable fisheries management - Min Xu; Xin yuan Yang; Xiao jing Song; Kai da Xu; Lin lin Yang (Aquaculture International, 2021)

Distinct tropical Pacific sea surface temperature anomaly regimes enhanced under recent global warming - Jing Li; Lin Mu; Linhao Zhong (International Journal of Climatology, 2021)
El Niño and Southern Oscillation (ENSO) events are usually monitored by tropical Pacific sea surface temperature anomaly (SSTA) patterns with dramatic impacts on the global climate. To explore the diversity of the tropical Pacific SSTA, a novel method combined empirical orthogonal function analysis and the K‐means clustering algorithm is carried out to classify SSTA patterns during 1950–2016. Meanwhile, the total distance variance and total silhouette value are introduced to determine an optimal number of distinguishable representative SSTA patterns. Ten SSTA patterns are obtained, which shows frequent basin‐wide warming and extreme cold ENSO events in recent decades. It may be attributed to the changes in composition of the intrinsic modes along with the background mode of slowly increasing east–west SST gradient. The comparative analysis between periods 1950–1969 and 1997–2016 suggests that the two regimes of tropical Pacific SSTA, featured as extreme warm and moderate warm/extreme cold patterns respectively, become more distinct under recent global warming.

Preliminary study on relationships among nutritional risk, serum prealbumin, and peripheral blood T cell subsets in patients with severe COVID-19 - Yanli Li; Yanbo Sun; Jing He; Peng Zhao; Pengju Luo; Jinsong Bai; Weiming Li; Shumin Li; Yueying Lin; Yunyun Cen (Infectious Diseases, 2021)

Identification and expression analysis of caffeoyl-coenzyme A O-methyltransferase family genes related to lignin biosynthesis in tea plant (Camellia sinensis) - Shi-Jia Lin; Ya-Zhuo Yang; Rui-Min Teng; Hao Liu; Hui Li; Jing Zhuang (Protoplasma, 2021)

Effects of shading on lignin biosynthesis in the leaf of tea plant (Camellia sinensis (L.) O. Kuntze) - Rui-Min Teng; Yong-Xin Wang; Hui Li; Shi-Jia Lin; Hao Liu; Jing Zhuang (Molecular Genetics and Genomics, 2021)

Co-transport of biochar colloids with organic contaminants in soil column - Rashida Hameed; Cheng Lei; Jing Fang; Daohui Lin (Environmental Science and Pollution Research, 2021)

A multi-attribute decision-making model for improving inefficient industrial parks - Sheng-Hau Lin; Danyang Wang; Xianjin Huang; Xiaofeng Zhao; Jing-Chzi Hsieh; Gwo-Hshiung Tzeng; Jia-Hsuan Li; Jia-Tsong Chen (Environment, Development and Sustainability, 2021)

Angle-Based Contact Detection in Discontinuous Deformation Analysis - Hong Zhang; Jing-wen Zhang; Wei Wu; Xi Wang; Hehua Zhu; Jeen-shang Lin; Jian-gang Chen (Rock Mechanics and Rock Engineering, 2020)

Synthesis, characteristics and medical applications of plant nanomaterials - Lidong Du; Ruoyu Zhang; Hanchao Yang; Shaojian Tang; Zhaohua Hou; Jinjin Jing; Bingjie Lin; Shujie Zhang; Zhong Lu; Peng Xue (Planta, 2020)

Effects of Single-Dose and Long-Term Ketamine Administration on Tau Phosphorylation–Related Enzymes GSK-3β, CDK5, PP2A, and PP2B in the Mouse Hippocampus - Yanning Li; Gehua Wen; Runtao Ding; Xinghua Ren; Chenchen Jing; Lin Liu; Jun Yao; Guohua Zhang; Yan Lu; Baoman Li; Xu Wu (Journal of Molecular Neuroscience, 2020)

Management of Gout-associated MSU crystals-induced NLRP3 inflammasome activation by procyanidin B2: targeting IL-1β and Cathepsin B in macrophages - Chun-Ying Qiao; Ying Li; Yue Shang; Min Jiang; Jian Liu; Zi-Ying Zhan; Huan Ye; Yong-Ce Lin; Jing-Ya Jiao; Rong-Hui Sun; Zhi-Hong Zhang; Mei-Hua Piao; et al. (Inflammopharmacology, 2020)

Melatonin ameliorates spatial memory and motor deficits via preserving the integrity of cortical and hippocampal dendritic spine morphology in mice with neurotrauma - Xiao-Jing Lin; Ruoxu Liu; Chenyi Li; Xueqing Yi; Bo Fu; M. J. Walker; Xiao-Ming Xu; Gang Sun; Cheng-Hsien Lin (Inflammopharmacology, 2020)

Epidemiological analysis of Group A Streptococcus infections in a hospital in Beijing, China - Hongxin Li; Lin Zhou; Yong Zhao; Lijuan Ma; Jing Xu; Yan Liu; Qin Qin; Jin Hu; Xiaoyan Liu (European Journal of Clinical Microbiology & Infectious Diseases, 2020)

Seasonal succession of phytoplankton in two temperate artificial lakes with different water sources - Jing Wei; Min Wang; Chongtai Chen; Haiming Wu; Li Lin; Ming Li (Environmental Science and Pollution Research, 2020)

The extract of aquatic macrophyte Carex cinerascens induced colony formation in bloom-forming cyanobacterium Microcystis aeruginosa - Lin Li; Xiao-ling Jing; Ling Wang; Zhi-gao Zeng; Wen-hong Chen; Jia-hao Zhai; Si-qin Qi (Environmental Science and Pollution Research, 2020)

Comparative performance assessment of landslide susceptibility models with presence-only, presence-absence, and pseudo-absence data - Dong-mei Zhao; Yuan-mei Jiao; Jin-liang Wang; Yin-ping Ding; Zhi-lin Liu; Cheng-jing Liu; Ying-mei Qiu; Juan Zhang; Qiu-e Xu; Chang-run Wu (Journal of Mountain Science, 2020)

Feeding Habits of Bigeye Tuna (Thunnus obesus) in the Western Indian Ocean Reveal a Size-Related Shift in Its Fine-Scale Piscivorous Diet - Chien-Hsiang Lin; Jing-Siang Lin; Kuo-Shu Chen; Meng-Hsien Chen; Chiee-Young Chen; Chih-Wei Chang (Frontiers in Marine Science, 2020)

Divergence in flowering time is a major component contributing to reproductive isolation between two wild rice species (Oryza rufipogon and O. nivara) - Xun Xu; Qing-Lin Meng; Mu-Fan Geng; Ning-Ning Ren; Lian Zhou; Yu-Su Du; Zhe Cai; Mei-Xia Wang; Xin Wang; Xiu-Hua Wang; Jing-Dan Han; Shuai Jiang; et al. (Science China Life Sciences, 2020)

Os4BGlu14, a monolignol β-Glucosidase, negatively affects seed longevity by influencing primary metabolism in rice - Rui-Juan Ren; Pei Wang; Li-Na Wang; Jing-Ping Su; Lin-Jing Sun; Yue Sun; De-Fu Chen; Xi-Wen Chen (Plant Molecular Biology, 2020)

Small grain and semi-dwarf 3, a WRKY transcription factor, negatively regulates plant height and grain size by stabilizing SLR1 expression in rice - Jie Lan; Qibing Lin; Chunlei Zhou; Yakun Ren; Xi Liu; Rong Miao; Ruonan Jing; Changling Mou; Thanhliem Nguyen; Xingjie Zhu; Qian Wang; Xin Zhang; et al. (Plant Molecular Biology, 2020)

Mechanism of contractile dysfunction induced by serotonin in coronary artery in spontaneously hypertensive rats - Hao Wang; Xiao-Yan Gao; Fang Rao; Hui Yang; Zhao-Yu Wang; Lin Liu; Su-Juan Kuang; Qi Wu; Chun-Yu Deng; Jing-Song Xu (Naunyn-Schmiedeberg's Archives of Pharmacology, 2020)

Two new species of Hortiboletus (Boletaceae, Boletales) from China - Hui-Jing Xie; Wen-Fei Lin; Shuai Jiang; Rou Xue; Lu-Ling Wu; Yu-Zhuo Zhang; Zhi-Qun Liang; Nian-Kai Zeng; Ming-Sheng Su (Mycological Progress, 2020)

MicroRNA-761 modulates foam cell formation and inflammation through autophagy in the progression of atherosclerosis - Chao Wang; Wei Yang; Xiaofei Liang; Wei Song; Jing Lin; Yan Sun; Xiuru Guan (Molecular and Cellular Biochemistry, 2020)

Diagnostic value of optic disc retinal nerve fiber layer thickness for diabetic peripheral neuropathy - Xiao-hong Wu; Jing-wen Fang; Yin-qiong Huang; Xue-feng Bai; Yong Zhuang; Xiao-yu Chen; Xia-hong Lin (Journal of Zhejiang University-SCIENCE B, 2020)

Complete mitochondrial genome of the freshwater fish Acrossocheilus longipinnis (Teleostei: Cyprinidae): genome characterization and phylogenetic analysis - Xiao-Jing Hou; Hung-Du Lin; Wen-Qiao Tang; Dong Liu; Chiao-Chuan Han; Jin-Quan Yang (Biologia, 2020)

New sorbicillinoid derivatives with GLP-1R and eEF2K affinities from a sponge-derived fungus Penicillium chrysogenum 581F1 - Min-Jia Cao; Tao Zhu; Jing-Tang Liu; Liang Ouyang; Fan Yang; Hou-Wen Lin (Natural Product Research, 2020)

Impact of prophylactic/preemptive donor lymphocyte infusion and intensified conditioning for relapsed/refractory leukemia: a real-world study - Yu Wang; Qi-Fa Liu; De-Pei Wu; Jing-Bo Wang; Xi Zhang; Heng-Xiang Wang; Feng Gao; Shun-Qing Wang; Zi-Min Sun; Jian Ouyang; Kai-Lin Xu; Su-Jun Gao; et al. (Science China Life Sciences, 2020)

Verticillin A inhibits colon cancer cell migration and invasion by targeting c-Met - Qian-qian Liu; Xue-li Zeng; Yue-lin Guan; Jing-xin Lu; Kai Tu; Fei-yan Liu (Journal of Zhejiang University-SCIENCE B, 2020)

MicroRNA-107 Ameliorates Damage in a Cell Model of Alzheimer’s Disease by Mediating the FGF7/FGFR2/PI3K/Akt Pathway - Wei Chen; Lin Wu; Yueqiang Hu; Lingfei Jiang; Ni Liang; Jing Chen; Hongling Qin; Nong Tang (Journal of Molecular Neuroscience, 2020)

COMT-Val158Met polymorphism modulates antipsychotic effects on auditory verbal hallucinations and temporal lobe gray matter volumes in healthy individuals—symptom relief accompanied by worrisome volume reductions - Chuanjun Zhuo; Langlang Cheng; Gongying Li; Yong Xu; Rixing Jing; Shen Li; Li Zhang; Xiaodong Lin; Chunhua Zhou (Brain Imaging and Behavior, 2020)
Investigation of auditory verbal hallucinations (AVHs) in schizophrenics is complicated by psychiatric symptoms. Investigating healthy individuals with AVHs (H-AVHs) can obviate such confounding factors. The objective of this study was to explore the effects of antipsychotic treatment on AVHs and gray matter volumes (GMVs) in H-AVH subjects and whether such are effects are influenced by COMT - Val158Met genotype. Magnetic resonance imaging (MRI) and genotyping studies were completed for 42 H-AVH subjects and 42 well-matched healthy controls (HCs). COMT-Met/Met homozygotes (158th codon) were identified as COMT-Met genotype; COMT-Met/Val heterozygotes and COMT-Val/Val homozygotes were identified as COMT-Val genotype. Data were compared across groups (H-AVH vs. HC, and between genotypes) with two-sample t-tests. The H-AVH COMT-Met group showed a stronger response to antipsychotic treatment than the H-AVH COMT-Val group ( p < 0.001). Both H-AVH genotype groups exhibited temporal lobe GMV reductions after treatment, and relative to their respective genotype-matched HC groups. Antipsychotic treatment effects in H-AVH subjects were influenced by COMT-Val158Met genotype and associated with widespread GMV reductions. These findings provide clues for further exploration of treatment targets for AVHs. Treatment associated GMV reductions, however, raise concerns about use of antipsychotics in H-AVH subjects.

Analysis of HBsAg mutations in the 25 years after the implementation of the hepatitis B vaccination plan in China - Huiming Ye; Jing Teng; Zhiyuan Lin; Ye Wang; Xiaochun Fu (Virus Genes, 2020)

Nutrient factor-dependent performance of bacterial quorum sensing system during population evolution - Kelei Zhao; Jing Li; Yang Yuan; Jiafu Lin; Xinrong Wang; Yidong Guo; Yiwen Chu (Archives of Microbiology, 2020)

Macrophage–NLRP3 Inflammasome Activation Exacerbates Cardiac Dysfunction after Ischemic Stroke in a Mouse Model of Diabetes - Hong-Bin Lin; Guan-Shan Wei; Feng-Xian Li; Wen-Jing Guo; Pu Hong; Ya-Qian Weng; Qian-Qian Zhang; Shi-Yuan Xu; Wen-Bin Liang; Zhi-Jian You; Hong-Fei Zhang (Neuroscience Bulletin, 2020)

Tyrosine Hydroxylase Gene Polymorphisms Contribute to Opioid Dependence and Addiction by Affecting Promoter Region Function - Jun-lin Liu; Shao-qing Li; Feng Zhu; Yu-xiang Zhang; Ya-nan Wu; Jing-si Yang; Bao Zhang; Chun-xia Yan (NeuroMolecular Medicine, 2020)

Impacts of injection temperature on the CO2 injection capacity in the different sloping formations - Jing Jing; Wei Zhou; Yanlin Yang; Lin Zuo; Zhonghua Tang (Environmental Science and Pollution Research, 2020)

Environmental Influence on the Spatiotemporal Variability of Spawning Grounds in the Western Guangdong Waters, South China Sea - Yao Lu; Jing Yu; Zhaojin Lin; Pimao Chen (Journal of Marine Science and Engineering, 2020)
Spawning grounds occupy an important position in the supplementary population of fishery resources, especially in Western Guangdong waters (WGWs) in the northern South China Sea (SCS), where fishery resources are being depleted. This study investigated the environmental effects on the spatiotemporal variability of spawning grounds in WGWs, on the basis of generalized additive models (GAMs) and central spawning-ground gravity (CoSGG) by using satellite and in situ observations. Results showed that 57.2% of the total variation in fish-egg density in WGWs was explained. On the basis of stepwise GAMs, the most important factor was sea surface salinity (SSS), with a contribution of 32.1%, followed by sea surface temperature (SST), water depth, month, and chlorophyll a concentration (Chl-a), with contributions of 10.7%, 8.8%, 2.6%, and 2.6%, respectively. Offshore distance had slight influence on the model, explaining approximately 0.4% of the variation in fish-egg density. In summary, fish eggs in WGWs were mainly distributed in the area with SSS of 32.0–34.0 Practical Salinity Unit (PSU), SST of 24–27 °C, and depth of 0–18 m. CoSGG shifted eastwards by 0.38° N and northwards by 0.26° E from April to June. The distribution of spawning grounds in the WGW was affected by the Western Guangdong coastal current (WGCC), cyclonic circulation, the SCS warm current (SCSWC), and changes in the habitat environment (such as SST). Fish in WGWs tend to spawn in areas with a high seabed slope and steep terrain (near the Qiongzhou Strait).

Initial chest CT findings in COVID-19: correlation with clinical features - Zhu-jing Shen; Nan Lu; Lu-lu Gao; Jian Lv; Hua-fu Luo; Ji-feng Jiang; Chao Xu; Shi-ya Li; Ju-jiang Mao; Kai Li; Xiao-pei Xu; Bin Lin (Journal of Zhejiang University-SCIENCE B, 2020)

Enhancement of the activity of Cu/TiO2 catalyst by Eu modification for selective catalytic reduction of NOx with NH3 - Yuan-zhen Liu; Qi-yan Xu; Rui-tang Guo; Chao-peng Duan; Gui-lin Wu; Yu-fang Miao; Jing-wen Gu (Environmental Science and Pollution Research, 2020)

Spatial Pattern of Female Non-agricultural Employment and Its Driving Forces in Guangdong Province, China: A Perspective of Individual and Family-level - Zhanhui Fu; Lin Mei; Yanjun Liu; Junfeng Tian; Rumin Zheng; Jing Tian (Chinese Geographical Science, 2020)

High-level soluble expression of human Cu,Zn superoxide dismutase with high activity in Escherichia coli - Jin-Ling Yang; Xing-Lun Li; Feng-Lin Jiang; Ting Gong; Jing-Jing Chen; Tian-Jiao Chen; Ping Zhu (World Journal of Microbiology and Biotechnology, 2020)

Selenium accumulation characteristics of Cyphomandra betacea (Solanum betaceum) seedlings - Linjin Lin; Jing Sun; Tonghao Cui; Xiong Zhou; Ming’an Liao; Yunmin Huan; Liu Yang; Caifang Wu; Xianmin Xia; Yuxi Wang; Zhiyu Li; Jinpeng Zhu; et al. (Physiology and Molecular Biology of Plants, 2020)

Role of adjuvant (chemo)radiotherapy for resected extrahepatic cholangiocarcinoma: a meta-analysis - Xin-qi Shi; Jing-yu Zhang; Hua Tian; Ling-na Tang; Ai-lin Li (Journal of Zhejiang University-SCIENCE B, 2020)

Association of KRAS mutation with tumor deposit status and overall survival of colorectal cancer - Meifang Zhang; Wenwei Hu; Kun Hu; Yong Lin; Zhaohui Feng; Jing-Ping Yun; Nan Gao; Lanjing Zhang (Cancer Causes & Control, 2020)

Enhanced Antitumor Efficacy of Curcumin-Loaded PLGA Nanoparticles Coated with Unique Fungal Hydrophobin - Lu Sun; Hui Xu; Jing-hua Xu; Shao-ning Wang; Jun-wei Wang; Hong-feng Zhang; Wei-ru Jia; Lin-sen Li (AAPS PharmSciTech, 2020)