Associations of exposure to lead and cadmium with risk of all-cause and cardiovascular disease mortality among patients with type 2 diabetes - Kai Zhu; Yuge Zhang; Qi Lu; Tingting Geng; Rui Li; Zhenzhen Wan; Xuena Zhang; Yujie Liu; Lin Li; Zixin Qiu; Meian He; Liegang Liu; et al. (Environmental Science and Pollution Research, 2022)

Enhanced soil respiration, vegetation and monsoon precipitation at Lantian, East Asia during Pliocene warmth - Kexin Wang; Huayu Lu; Carmala N. Garzione; Lin Zhao; Chenghong Liang; Shuyue Li; Daniel O. Breecker; Fang Lei; Hongyan Zhang (Climate Dynamics, 2022)

Complete genome sequence of iris potyvirus B infecting Lilium lancifolium in China - Qi Lin; Dankan Yan; Mengying Hua; Yueyan Yin; Hongying Zheng; Jianping Chen; Fei Yan; Jiejun Peng; Qiongji He; Yuwen Lu (Archives of Virology, 2022)

PDGFD switches on stem cell endothelial commitment - Weisi Lu; Peipei Xu; Boxiong Deng; Jianing Zhang; Ying Zhan; Xianchai Lin; Xiangzhong Xu; Zhaoxia Xia; Xiaoxi Yang; Xiaoling Zeng; Lijuan Huang; Bingbing Xie; et al. (Angiogenesis, 2022)
The critical factors regulating stem cell endothelial commitment and renewal remain not well understood. Here, using loss- and gain-of-function assays together with bioinformatic analysis and multiple model systems, we show that PDGFD is an essential factor that switches on endothelial commitment of embryonic stem cells (ESCs). PDGFD genetic deletion or knockdown inhibits ESC differentiation into EC lineage and increases ESC self-renewal, and PDGFD overexpression activates ESC differentiation towards ECs. RNA sequencing reveals a critical requirement of PDGFD for the expression of vascular-differentiation related genes in ESCs. Importantly, PDGFD genetic deletion or knockdown increases ESC self-renewal and decreases blood vessel densities in both embryonic and neonatal mice and in teratomas. Mechanistically, we reveal that PDGFD fulfills this function via the MAPK/ERK pathway. Our findings provide new insight of PDGFD as a novel regulator of ESC fate determination, and suggest therapeutic implications of modulating PDGFD activity in stem cell therapy.

Long‐term drought aggravates instability of alpine grassland productivity to extreme climatic event - Yun L. He; Jin S. Wang; Da S. Tian; Quan Quan; Lin Jiang; Fang F. Ma; Lu Yang; Fang Y. Zhang; Qing P. Zhou; Shu L. Niu (Ecology, 2022)
The frequency and severity of extreme weather events are increasing and expected to increase more in the future, together with global change. However, how extreme events and global change factors interactively influence community structures and ecosystem processes is largely unknown. Here, we investigated the responses of the temporal stability and resilience of aboveground net primary productivity (ANPP) of an alpine meadow to an extreme flooding event under different treatments of experimental drought and clipping. We found that ecosystems that were exposed to drought treatments for 3 years significantly decreased the temporal stability of community productivity but increased resilience to flooding, whereas their resistance to or recovery from flooding did not change. Neither clipping nor its interaction with drought altered the responses of these community stability metrics to flooding. Drought treatments significantly decreased plant species richness and asynchrony and dominant species stability, leading to a decrease in temporal stability and an increase in resilience in response to the extreme flooding event. The study also revealed that the change in species asynchrony was the dominant impact pathway determining the responses of resilience and temporal stability to flooding. Our results highlight that alpine grassland that experiences a multiyear drought may aggravate the instability of community productivity to extreme climatic events by reducing species asynchrony.

Research on the Enhancement of the Separation Efficiency for Discrete Phases Based on Mini Hydrocyclone - Lin Liu; Lixin Zhao; Yahong Wang; Shuang Zhang; Minhang Song; Xueqiang Huang; Zhongrun Lu (Journal of Marine Science and Engineering, 2022)
The economic and efficient treatment of mixed media in offshore produced fluids is of great significance to oilfield production. Due to the small space and limited load-bearing capacity of offshore platforms, some mature multiphase media separation processes in onshore oilfields are difficult to apply. Therefore, high-efficiency processing methods with small-occupied space are required. Mini hydrocyclones (MHCs) are a potential separation method due to their simple structure, small footprint, and high separation efficiency (especially for fine particles or droplets). However, for discrete phases with different densities and sizes, the enhancement rule of the separation efficiency of MHCs is not yet clear. In this paper, numerical simulation methods were used to study the separation performance of hydrocyclones with different main diameters (including conventional hydrocyclones (CHCs) and MHCs) for discrete phases with different densities and particle sizes. Results show that MHC has the optimal enhancement range for oil–water separation when oil-droplet sizes are 60–300 μm, while the optimal enhancement range for silica particle and water separation is 10–40 μm. For other droplet/particle size ranges, the efficiency enhancement effect of MHC is not obvious compared to conventional hydrocyclones. By calculating the radial force of particles in MHC and CHC, the reasons for the enhanced efficiency of MHC are theoretically analyzed. The pressure drop of MHC is higher than CHC under the same feed velocity, which can be improved by connecting CHC with MHC. Additionally, the fluid velocity test experiments based on particle image velocimetry (PIV) were carried out to verify the accuracy of the numerical simulations. This study clarified the scope of application of MHCs to different discrete phase types, in order to provide a basis for the precise application of MHCs.

Land Subsidence Evolution and Simulation in the Western Coastal Area of Bohai Bay, China - Can Lu; Lin Zhu; Xiaojuan Li; Huili Gong; Dong Du; Haigang Wang; Pietro Teatini (Journal of Marine Science and Engineering, 2022)
Groundwater overexploitation and loading of buildings have been the main factors triggering land subsidence along the west coast of Bohai Bay, China, since the 2000s. Uneven subsidence has been causing damage to buildings and civil facilities, loss of elevation, increasing the risk of flood and seawater intrusion, and threatening the safety of people’s lives and property. This paper analyzed the spatial and temporal features of land subsidence along the coastal area from 2003 to 2010 and from 2015 to 2020, respectively. The relations between the initiating factors and land subsidence were explored. Then, the simulation model of land subsidence was constructed through a deep learning method. During the process, multiple data were collected, including land satellite (Landsat), environmental satellite advanced synthetic aperture radar (ENVISAT ASAR) and Sentinel-1 images, leveling data, lithological data, and groundwater level data. The area occupied by buildings and vertical displacement were extracted by using supervised classification, small baseline subset (SBAS), and persistent scatterer interferometry (PSI) technologies. The gated recurrent unit (GRU) neural network was adopted to simulate the evolution of land subsidence. Results showed that the maximum annual vertical displacement rate decreased from −94 mm/yr during 2003–2010 to −87 mm/yr during 2015–2020. The correlation efficiency between the groundwater level of the third confined aquifer group and land subsidence was larger than the area occupied by buildings and the compressible layer thickness with subsidence. The constructed GRU neural network model can simulate subsidence from September 2019 to December 2019, with the overall RMSE and MAE being 3.16 mm and 2.19 mm, respectively. This work can facilitate an understanding of the evolution and prevention of land subsidence along the west coast of Bohai Bay, which will provide information for policy decisions and flood-fighting plans of the worldwide coastal cities.

Diversity and distribution of Perkinsus spp. along the coast of China: Implications for widespread transmission of Perkinsus spp. in mollusks - Lingtong Ye; Lin Wu; Jie Lu; Tuo Yao; Jiangyong Wang; Shaokun Shi; Gang Yu; Wang Zhao (Frontiers in Marine Science, 2022)
Perkinsus species, which are parasitic pathogens of mollusks, have been transmitted and dispersed to various molluscan species along the coastal waters of many countries. However, few studies have addressed the diversity and distribution of Perkinsus spp. along the coast of China. Here we used conventional PCR amplification and sequencing techniques, combined with a qPCR assay as a confirmatory test, to evaluate the prevalence of Perkinsus species in molluscan species among different sea regions of China. Three Perkinsus species —P. olseni , P. beihaiensis , and P. chesapeaki— were detected, with P. chesapeaki reported for the first time along the Chinese coast. Seven of eight molluscan species carried Perkinsus species, including Crassostrea gigas , C. hongkongensis , Sinonovacula constricta , Ruditapes philippinarum , Scapharca subcrenata , Meretrix lyrate , and Haliotis diversicolor . Perkinsus olseni was prominent in the Yellow and Bohai Sea and East China Sea, while P. beihaiensis was prominent in the South China Sea. Most of the molluscan species carried Perkinsus spp. with the medium or low levels of PCR-prevalence (<30%). The three Perkinsus species possess high levels of internal transcriber spacer haplotypes, some of which are shared among many countries. The much higher PCR-prevalence of Perkinsus spp. in the clam Ruditapes philippinarum and the oyster Crassostrea hongkongensis suggests that Perkinsus species may be transmitted and dispersed to other mollusks through the transportation of Perkinsus -carried R. philippinarum and C. hongkongensis . Perkinsus carrying tended to be generally linked with a broader geographic range, lower prevalence, more diversified molluscan hosts, and more diversified Perkinsus haplotypes.

Ballast Water Dynamic Allocation Optimization for Revolving Floating Cranes Based on a Hybrid Algorithm of Fuzzy-Particle Swarm Optimization with Domain Knowledge - Qiao Liu; Zhenxing Lu; Zhijie Liu; Peng Lin; Xiaobang Wang (Journal of Marine Science and Engineering, 2022)
Ballast systems and ballast water dynamic allocation between ballast tanks are very important for ensuring the offshore operation efficiency and safety of the revolving floating crane (RFC). Its modeling and solving have multiple difficulties such as modeling complexity, solving complexity and engineering practicability. Early studies showed that domain knowledge is of great significance for the optimization of the design quality and innovation of such complex engineering issues. By analyzing the coupled operation process characteristics among the floating crane, ship hull and ballast system, a ballast water allocation optimization model based on dynamic programming strategy is established. The domain knowledge of ship ballasting is extracted, and a domain knowledge base of expert experience rules for the ballast water allocation is established. A Fuzzy-Particle Swarm Optimization (FPSO) algorithm is given to obtain the optimal allocation scheme, which uses fuzzy logic inference to process domain knowledge and improve the solving quality. Three different cases are given to illustrate the validity of the proposed model and algorithm by comparing it with other algorithms. The analysis results show that the established optimization method can effectively improve the operation efficiency and reduce the calculation time and the number of ballast tanks involved in allocation, which makes the optimal scheme more suitable for engineering applications.

Seismic Shot Gather Denoising by Using a Supervised-Deep-Learning Method with Weak Dependence on Real Noise Data: A Solution to the Lack of Real Noise Data - Xintong Dong; Jun Lin; Shaoping Lu; Xingguo Huang; Hongzhou Wang; Yue Li (Surveys in Geophysics, 2022)

The Key Role of Magnetic Resonance Imaging in the Detection of Neurodegenerative Diseases-Associated Biomarkers: A Review - Ke-Ru Li; An-Guo Wu; Yong Tang; Xiao-Peng He; Chong-Lin Yu; Jian-Ming Wu; Guang-Qiang Hu; Lu Yu (Molecular Neurobiology, 2022)

Fracture Mechanical Properties of Three—Dimensional Irregular Sandstone Particles Based on Digital-Image - Kai-wen Shi; Yu-jun Zuo; Wen-ji-bin Sun; Hao Liu; Jian-yun Lin; Tao-tao Li; Bin Chen; Lu-lin Zheng (Geotechnical and Geological Engineering, 2022)

How Frequently Will the Persistent Heavy Rainfall over the Middle and Lower Yangtze River Basin in Summer 2020 Happen under Global Warming? - Zi-An Ge; Lin Chen; Tim Li; Lu Wang (Advances in Atmospheric Sciences, 2022)

Editorial: Carbon storage by marine microorganisms for carbon neutrality - Zhili He; Lu Lin; Xin Wang; Wei Qin; Chuanlun Zhang (Frontiers in Marine Science, 2022)

Effect modification by aging on the associations of nicotine exposure with cognitive impairment among Chinese elderly - Jian Hou; Chao Huang; Bo Zhu; Wei Liu; Qing-qing Zhu; Lu Wang; Tian Li; Chun-jie Yuan; Shao-yang Lai; De-sheng Wu; Fei-qi Zhu; Jia-fei Zhang; et al. (Environmental Science and Pollution Research, 2022)

Wheat genomic study for genetic improvement of traits in China - Jun Xiao; Bao Liu; Yingyin Yao; Zifeng Guo; Haiyan Jia; Lingrang Kong; Aimin Zhang; Wujun Ma; Zhongfu Ni; Shengbao Xu; Fei Lu; Yuannian Jiao; et al. (Science China Life Sciences, 2022)

Studying bona fide SARS-CoV-2 biology in a BSL-2 biosafety environment using a split-virus-genome system - Yingxin Ma; Guobin Mao; Weishan Yang; Guoqiang Wu; Guoqiang Li; Xiaoying Li; Xin Lin; Junnan Lu; Shijun Zhao; Wei Zhao; Junbiao Dai; Xian-En Zhang (Science China Life Sciences, 2022)

Novel Self-Assembled Micelles With Increased Tumor Penetration and Anti-Tumor Efficiency Against Breast Cancer - Yani Yang; Yuezhu Zhao; Jie Liu; Chen Ge; Weiwei Zhang; Yue Zhang; Junji Wang; Guohao Sun; Xiujun Lin; Xiaohong Lu; Xiang Tang; Jun He; et al. (Pharmaceutical Research, 2022)

Interdecadal change in the influence of El Niño in the developing stage on the central China summer precipitation - Lin Chen; Gen Li; Shang-Min Long; Chujie Gao; Zhiyuan Zhang; Bo Lu (Climate Dynamics, 2022)

ZAKβ Alleviates Oxidized Low-density Lipoprotein (ox-LDL)-Induced Apoptosis and B-type Natriuretic Peptide (BNP) Upregulation in Cardiomyoblast - Yueh-Min Lin; Jiro Hasegawa Situmorang; Jia-Zun Guan; Dennis Jine-Yuan Hsieh; Jaw-Ji Yang; Michael Yu-Chih Chen; Ching-Hui Loh; Chia-Hua Kuo; Shang-Yeh Lu; Ying-Ming Liou; Chih-Yang Huang (Cell Biochemistry and Biophysics, 2022)

Characteristics and geochemical implications of light hydrocarbons from ultra-deep Ordovician oils in the North Shuntuoguole area, Tarim Basin - Li Dong; Anlai Ma; Huixi Lin; Lu Yun; Weilong Peng; Xiuxiang Zhu (Frontiers of Earth Science, 2022)

Climatology of aerosol types and their vertical distribution over East Asia based on CALIPSO lidar measurements - Lu Gui; Minghui Tao; Yi Wang; Lunche Wang; Liangfu Chen; Changqing Lin; Jinhua Tao; Jun Wang; Chao Yu (International Journal of Climatology, 2022)
Aerosol vertical distribution generally determines their health impacts and climate effects. By using long‐term (2007–2019) CALIPSO lidar measurements, we present a large‐scale insight into the climatology of aerosol types and their vertical structure over East Asia. Despite the low sampling frequency, comparison with MODIS aerosol optical depth (AOD) shows that the integrated CAIPSO vertical extinction can reasonably reproduce spatial patterns of the aerosol loading. With the unique advantage of active detection, CALIPSO reveals an obvious enhancement of the night‐time AOD due to worse diffusion conditions. Moreover, long‐range transport of different aerosols including dust, polluted dust, and smoke has substantial contribution to the aerosol loading over East Asia. Pure dust particles are mainly concentrated over the deserts with notable dust transport belts (dust AOD > 0.2 at 532 nm) along downwind regions during winter and spring. By contrast, polluted dust is prevalent over the downstream eastern China with much higher AODs throughout the year. In particular, AOD of polluted dust (~0.5) is higher in winter rather than in spring, which is consistent with their seasonal occurrences. Smoke aerosols usually appear in the night‐time over southern China. The top heights of aerosols are around 4–6 km, with dust and smoke having higher extinction at upstream regions. The climatology of these aerosol types and vertical distribution can provide a significant constraint for associated studies of air quality and climate effects.

Age, Growth and Population Structure Analyses of the Purpleback Flying Squid Sthenoteuthis oualaniensis in the Northwest Indian Ocean by Beak Microstructure - Hua-Jie Lu; Yu-Zhe Ou; Jing-Ru He; Mao-Lin Zhao; Zi-Yue Chen; Xin-Jun Chen (Journal of Marine Science and Engineering, 2022)
To explore the feasibility of using beak microstructure information to estimate the age of Sthenoteuthis oualaniensis, the microstructures of the upper beaks of individual squid were applied in this work to analyze the ages and growth patterns of squid caught from February–May 2019 and from October–December 2020 in the northwest Indian Ocean. The results indicated that the squid samples in the two years were no older than 9 months, and the samples in 2019 were autumn population and 2020 were spring population. The linear growth model of the autumn population (2019) was the best model for describing the relationship between age and ML, while the power model of the spring population (2020) was the best for describing the relationship between age and ML. The maximum instantaneous growth rate (IGR) and absolute daily growth rate (AGR) values of the spring population were 0.24%/d and 1.09 mm/d, respectively, occurring in squid between 200 and 220 days of age. The maximum IGR and AGR values of the autumn population were 0.69%/d and 1.73 mm/d, respectively, occurring in squid between 200 and 240 days of age. The period from 141–260 days (5–8 months) was considered to correspond to the subadult stage in the whole life history of S. oualaniensis in the Northwest Indian Ocean. The beak microstructure information can be effectively applied to estimate the age of S. oualaniensis individuals.

Chromosomal mapping of a locus associated with adult-stage resistance to powdery mildew from Agropyron cristatum chromosome 6PL in wheat - Yida Lin; Shenghui Zhou; Xuezhong Liang; Baojin Guo; Bing Han; Haiming Han; Jingpeng Zhang; Yuqing Lu; Zhi Zhang; Xinming Yang; Xiuquan Li; Weihua Liu; et al. (Theoretical and Applied Genetics, 2022)

Estimating litchi flower number using a multicolumn convolutional neural network based on a density map - Jiaquan Lin; Jun Li; Zhou Yang; Huazhong Lu; Yunhe Ding; Huajun Cui (Precision Agriculture, 2022)

Activation of the TREK-1 Potassium Channel Improved Cognitive Deficits in a Mouse Model of Alzheimer’s Disease by Modulating Glutamate Metabolism - Fang Li; Shu-ning Zhou; Xin Zeng; Zhen Li; Rui Yang; Xue-xi Wang; Bin Meng; Wei-lin Pei; Li Lu (Molecular Neurobiology, 2022)

IL-38, a potential therapeutic agent for lupus, inhibits lupus progression - Wang-Dong Xu; Lin-Chong Su; Lu Fu; You-Yu Lan; Xiao-Yan Liu; Qi Huang; Qian Wu; Jie Zhou; An-Fang Huang (Inflammation Research, 2022)

The efficacy and safety of TNF inhibitor (golimumab) as salvage treatment in patients with refractory noninfectious uveitis - Yi Jin; Shanshan Lu; You Lin; Xiaoyue Mou (Inflammopharmacology, 2022)

The characteristics of alkaline phosphatase activity and phoD gene community in heavy-metal contaminated soil remediated by biochar and compost - Haiwei Lu; Chong Xu; Jiachao Zhang; Chunyan Du; Genyi Wu; Lin Luo (Bulletin of Environmental Contamination and Toxicology, 2022)

Sex differences in microstructural alterations in the corpus callosum tracts in drug-naïve children with ADHD - Qingxia Lin; Xuan Bu; Hong Chen; Yan Liang; Weiqian Wang; Yanhong Yi; Haixi Lin; Lu Lu; Yingxue Gao; Andan Qian; Shuangli Chen; Meihao Wang; et al. (Brain Imaging and Behavior, 2022)

Assessing the effect of probiotics on tilapia lake virus‐infected tilapia: Transmission and immune response - Ying‐Fei Yang; Jidapa Yamkasem; Win Surachetpong; Yi‐Jun Lin; Shu‐Han You; Tien‐Hsuan Lu; Chi‐Yun Chen; Wei‐Min Wang; Chung‐Min Liao (Journal of Fish Diseases, 2022)
Probiotics have been used to alleviate disease transmission in aquaculture. However, there are limited studies on probiotic use in modulating tilapia lake virus (TiLV). We assessed commercially available probiotic supplements used in TiLV‐infected tilapia and performed mortality and cohabitation assays. We developed a mechanistic approach to predict dose–response interactions of probiotic effects on mortality and immune gene response. We used a susceptible–infected–mortality disease model to assess key epidemiological parameters such as transmission rate and basic reproduction number ( R 0 ) based on our viral load dynamic data. We found that the most marked benefits of probiotics are significantly associated with immune system enhancements (~30%) and reductions in disease transmission (~80%) and R 0 (~70%) in tilapia populations, resulting in a higher tolerance of farming densities (~400 fold) in aquaculture. These findings provide early insights as to how probiotic use‐related factors may influence TiLV transmission and the immune responses in TiLV‐infected tilapia. Our study facilitates understanding the mode of action of probiotics in disease containment and predicting better probiotic dosages in diet and supplements to achieve the optimal culturing conditions. Overall, our analysis assures that further study of rationally designed and targeted probiotics, or mechanistic modelling is warranted on the basis of promising early data of this approach.

Metatranscriptomic analysis of host response and vaginal microbiome of patients with severe COVID-19 - Meng Xiao; Bo Lu; Rui Ding; Xia Liu; Xian Wu; Yaqian Li; Xudong Liu; Lin Qiu; Zhibo Zhang; Jing Xie; Yu Chen; Dong Zhang; et al. (Science China Life Sciences, 2022)

Context-dependent effects of inflammation on retina regeneration - Cuiping Zhou; Xiaoli Zhang; Yuxi Chen; Zihao Lin; Shuqiang Zhang; Zhiqiang Zhang; Lining Cao; Huaijin Guan; Jianfeng Lu; Hui Xu (Molecular Neurobiology, 2022)

ZNF750 facilitates carcinogenesis via promoting the expression of long non-coding RNA CYTOR and influences pharmacotherapy response in colon adenocarcinoma - Lu Xia; Hexin Lin; Yanming Zhou; Jiabian Lian (Journal of Zhejiang University-SCIENCE B, 2022)

New insight into the co-adsorption of oxytetracycline and Pb(II) using magnetic metal–organic frameworks composites in aqueous environment: co-adsorption mechanisms and application potentials - Meng-lu Wang; Zhe Zhao; Shumin Lin; Ming Su; Bolong Liang; Shu-xuan Liang (Environmental Science and Pollution Research, 2022)

Associations Between Plasma Metals and Cognitive Function in People Aged 60 and Above - Junling Zhang; Qiumei Liu; Min Xu; Jiansheng Cai; Yanfei Wei; Yinxia Lin; Xiaoting Mo; Shenxiang Huang; Shuzhen Liu; Chunbao Mo; Tingyu Mai; Dechan Tan; et al. (Biological Trace Element Research, 2022)

Low-carbon stabilization/solidification of municipal solid waste incineration fly ash - Chen Sun; Lei Wang; Xiaoqing Lin; Shengyong Lu; Qunxing Huang; Jianhua Yan (Waste Disposal & Sustainable Energy, 2022)

Characterization of Water Transport in Porous Building Materials Based on an Analytical Spontaneous Imbibition Model - Ming-Liang Qu; Sheng-Yue Lu; Qingyang Lin; Sajjad Foroughi; Zi-Tao Yu; Martin J. Blunt (Transport in Porous Media, 2022)

Phosphorus fertilization affects soybean rhizosphere phosphorus dynamics and the bacterial community in karst soils - Jihui Tian; Xing Lu; Qianqian Chen; Xizhi Kuang; Cuiyue Liang; Lansheng Deng; Dongjiao Lin; Kunzheng Cai; Jiang Tian (Plant and Soil, 2022)

Chaperone-mediated Autophagy Regulates Cell Growth by Targeting SMAD3 in Glioma - Hanqun Liu; Yuxuan Yong; Xingjian Li; Panghai Ye; Kai Tao; Guoyou Peng; Mingshu Mo; Wenyuan Guo; Xiang Chen; Yangfu Luo; Yuwan Lin; Jiewen Qiu; et al. (Neuroscience Bulletin, 2022)

Chromosome-level Genome Assembly of Acanthopagrus latus Provides Insights into Salinity Stress Adaptation of Sparidae - Jianguo Lu; Dong Gao; Ying Sims; Wenyu Fang; Joanna Collins; James Torrance; Genmei Lin; Jingui Xie; Jian Liu; Kerstin Howe (Marine Biotechnology, 2022)

TREM-2 mediates dendritic cell–induced NO to suppress Th17 activation and ameliorate chronic kidney diseases - Ching-Cheng Lin; Ti-Yung Chang; Yong-Chen Lu; Yun-Syuan Wu; Wei Huang; Wei-Chi Lo; Guan-Fu Liu; Wei-Chan Hsu; Pamela S. Ohashi; Tak W. Mak; Jong-Ling Fuh; Hui-Chen Chen; et al. (Journal of Molecular Medicine, 2022)

Combined System of Organic Substrate and Straw-Degrading Microbial Agents Improved Soil Organic Matter Levels and Microbial Abundance in a Rice–Wheat Rotation - Shi-Li Song; Xue Luo; Hao Wu; Xiao-Lin Lu; Fang-Ji Xu; Zhen-Hua Zhang; Yong-Xiang Guan; Chuan-Chao Dai (Current Microbiology, 2022)

Logging evaluation of shale oil “sweet spot” in Da’anzhai member, Longgang area, Sichuan Basin - Zonghui Lin; Jungang Lu; Rui Zhang; Shaoming Zhang; Longxiang Tang; Zhanghao Liu; Yaoting Li (Arabian Journal of Geosciences, 2022)

Microcosmic Characteristics of Hydrate Formation and Decomposition in the Different Particle Size Sediments Captured by Cryo-SEM - Jingsheng Lu; Decai Lin; Dongliang Li; Deqing Liang; Long Wen; Siting Wu; Yiqun Zhang; Yong He; Lingli Shi; Youming Xiong (Journal of Marine Science and Engineering, 2022)
Sand production and sand control studies in non-diagenetic reservoirs are the weak point in the conventional petroleum industry. However, natural gas hydrate (NGH) mainly exists in non-diagenetic strata, and sand production occurs during exploitation, which restricts the safe and sustainable production of NGH. To study the microcosmic characteristics of sand production, the hydrate decomposition behaviours in the sediments were captured by the Cryo-SEM method. The micromorphology of different particle sizes of sand samples containing NGH (the sand median diameter d50 is 150, 87, 55, 38, 24, and 13 µm) and the microcosmic processes of NGH decomposition were observed. Then, the microcosmic characteristics of sand production, during the decomposition process, were analysed. (1) The gas hydrate decomposition increases pore space and reduces reservoir strength; the expansion action of the decomposition of water and gas, the softening action of the decomposition of water, and the compression action by overlying stress (crustal stress) promoted sand production, deformation, and subsidence of the NGH reservoirs in the mining process. (2) The decomposition of NGH has a more significant impact on sediments with smaller particle sizes. (3) The particle size of NGH may be larger than the particle size of the mud in the reservoirs, and acting as “gravel” plays a particular role in sand control. Therefore, the particle size of NGH cannot be ignored in the design of sand control. (4) It has been revealed, and verified, that sputtering (splashing) is a unique process of sand production caused by NGH decomposition. In other words, the rapid expansion of the volume of the decomposed gas and water from NGH leads to the eruption and sputtering of hydrate particles, providing the driving force for sand migration, which is a different process of sand production than in conventional oil and gas.

Comparative Transcriptomics of Gonads Reveals the Molecular Mechanisms Underlying Gonadal Development in Giant Freshwater Prawns (Macrobrachium rosenbergii) - Guang Yang; Zhendong Qin; Zhijie Lu; Rishen Liang; Lijuan Zhao; Gan Pan; Li Lin; Kai Zhang (Journal of Marine Science and Engineering, 2022)
The giant freshwater prawn, Macrobrachium rosenbergii, is a prawn that has economic significance throughout the world. It exhibits sex-related growth dimorphism, whereby the males grow significantly more rapidly than the females. Therefore, a study on the molecular regulatory mechanism, which underlies the sexual differentiation of M. rosenbergii, is of both scientific and commercial importance. However, a scarcity of genomic and transcriptomic resources severely limits our knowledge of the sexual differentiation mechanisms in M. rosenbergii. Here, transcriptome sequencing of several gonadic samples of males and females in M. rosenbergii was performed to investigate the molecular basis underlying gonadal development. Our results showed that 2149 unigenes presented as differentially expressed genes (DEGs) in the ovaries of females compared to the testes of males, which contained 484 down-regulated and 1665 up-regulated genes. Enrichment analysis of DEGs revealed many of these genes to be related to sexual differentiation and gonadal development. From our transcriptome analyses, and as confirmed by quantitative real-time PCR, male-related genes (Mrr, MRPINK, IR, IAGBP, TESK1, and dsx) in the testes were significantly up-regulated, and female-related genes (ERR, Sxl3, cyclinB, Dmrt99B, PPP2A, and ADCY9) in the ovaries were also significantly up-regulated. This indicates the potential role these genes play in the gonadal development of M. rosenbergii. Furthermore, multiple signal transduction pathways relating to gonadal maturation and spermatogenesis, including MAPK, were identified herein. Our data also supports previous ideas that IAG and IAGBP-IR signaling schemes could help in the regulation of testis’ development in M. rosenbergii and the ERR gene could regulate ovarian development by affecting the expression of cyclinB, PPP2A, and ADCY9. The data from this study provides incredibly usefully genomic resources for future research on the sexual differentiation and practical aquaculture of M. rosenbergii.

Editorial: Omics and Fish Nutrition - Kang-le Lu; Samad Rahimnejad; Song-lin Li (Frontiers in Marine Science, 2022)

Dominant Fungal Epiphytes Promote Growth of the Invasive Plant Ipomoea cairica Through Hormone Interactions - Hua Xu; Ping Chang; Shaoshan Li; Jianguo Lu; Xuejun Lin; Can Xie (Journal of Plant Growth Regulation, 2022)

Bioeconomic evaluation of Eleutheronema tetradactylum farming: a case study in Taiwan - Cheng-Ting Huang; Farok Afero; Fang-Yu Lu; Bo-Ying Chen; Po-Lin Huang; Hsun-Yu Lan; Yen-Lung Hou (Fisheries Science, 2022)

An implementation framework of blockchain-based hazardous waste transfer management system - Guanghan Song; Yujie Lu; Haibo Feng; Han Lin; Yang Zheng (Environmental Science and Pollution Research, 2022)

Spatial–temporal patterns of summer urban islands and their economic implications in Beijing - Lu Lin; Lina Meng; Yingdan Mei; Wenting Zhang; Hui Liu; Weiling Xiang (Environmental Science and Pollution Research, 2022)

Responses of nitrous oxide fluxes to autumn freeze–thaw cycles in permafrost peatlands of the Da Xing’an Mountains, Northeast China - Liquan Song; Shuying Zang; Lin Lin; Boquan Lu; Chaofeng Sun; Yaqing Jiao; Hanxi Wang (Environmental Science and Pollution Research, 2022)

Diffeomorphic registration for retinotopic maps of multiple visual regions - Yanshuai Tu; Xin Li; Zhong-Lin Lu; Yalin Wang (Brain Structure and Function, 2022)

Deformation characteristics and thresholds of the Tanjiawan landslide in the Three Gorges Reservoir Area, China - Fu-ling Zhang; Mao-lin Deng; Qing-lin Yi; Shu-qiang Lu; Wei-jun Zheng; Hai-feng Huang; Xing Zhu (Journal of Mountain Science, 2022)

Shinella oryzae sp. nov., a novel zearalenone-resistant bacterium isolated from rice paddy soil - Ruyu Gao; Juan Zheng; Wei Lu; Xiubin Ke; Ming Chen; Min Lin; Wei Zhang; Zhengfu Zhou (Antonie van Leeuwenhoek, 2022)

Soil phosphorus drives plant trait variations in a mature subtropical forest - Erqian Cui; Ruiling Lu; Xiaoni Xu; Huanfa Sun; Yang Qiao; Jiaye Ping; Shuying Qiu; Yihua Lin; Jiehuan Bao; Yutong Yong; Zemei Zheng; Enrong Yan; et al. (Global Change Biology, 2022)
Earth system models are implementing soil phosphorus dynamic and plant functional traits to predict functional changes in global forests. However, the linkage between soil phosphorus and plant traits lacks empirical evidence, especially in mature forests. Here, we examined the soil phosphorus constraint on plant functional traits in a mature subtropical forest based on observations of 9943 individuals from 90 species in a 5‐ha forest dynamic plot and 405 individuals from 15 species in an adjacent 10‐year nutrient‐addition experiment. We first confirmed a pervasive phosphorus limitation on subtropical tree growth based on leaf N:P ratios. Then, we found that soil phosphorus dominated multidimensional trait variations in the 5‐ha forest dynamic plot. Soil phosphorus content explained 44% and 53% of the variance in the traits defining the main functional space across species and communities, respectively. Lastly, we found much stronger phosphorus effects on most plant functional traits than nitrogen at both species and community levels in the 10‐year nutrient‐addition experiment. This study provides evidence for the consistent pattern of soil phosphorus constraint on plant trait variations between the species and community levels in a mature evergreen broadleaf forest in the East Asian monsoon region. These findings shed light on the predominant role of soil phosphorus on plant functional trait variations in mature subtropical forests, providing new insights for models to incorporate soil phosphorus constraint in predicting future vegetation dynamics.

Hypothermal Effects on Energy Supply for Ionocytes in Gills of Freshwater- and Seawater-Acclimated Milkfish, Chanos chanos - Chia-Hao Chang; Chia-Jui Liu; Wei-Jie Lu; Li-Yang Wu; Kuang-Jie Lai; Yu-Ting Lin; Tsung-Han Lee (Frontiers in Marine Science, 2022)
The milkfish, Chanos chanos , is an important aquaculture species that can be cultured in freshwater (FW) and seawater (SW) ponds because of its high euryhalinity. In winter, cold snap leading to high mortality of this tropical species is a critical issue for the aquaculture industry in Taiwan. Under hypothermal stress, however, changes in energy supply for osmoregulation of this euryhaline species is intriguing. In this study, we used an antibody against glycogen phosphorylase (GP) to identify glycogen-rich (GR) cells distributed adjacent to the mitochondria-rich (MR) ionocytes in milkfish gills. Glucose transporter 1 (GLUT1), which plays a major role in energy supply, was also identified and localized in GR cells. Moreover, the expression of indicators of aerobic metabolism and energy production, citrate synthase (CS) and cytochrome c oxidase (COX), were analyzed in gills of FW- and SW-acclimated milkfish to reveal different strategies of energy utilization under hypothermal stress. When exposed to a low-temperature environment, SW individuals used branchial glycogen and lactate to match the energy demands of aerobic metabolism in ionocytes, and elevated aerobic capacity to support and maintain normal functions in gills. However, branchial glycogen mainly localized in the GR cells of FW milkfish was not utilized under hypothermal stress. Meanwhile, a similar level of branchial COX activity and COXIV protein abundance at low temperatures between FW and SW milkfish indicated similar energy requirements in gills. This suggested that another source, but not branchial glycogen, maintained the energy demand in FW milkfish. The present study illustrated differential energy supply strategies in gills between SW- and FW-acclimated milkfish for osmoregulation under low temperatures.

First report of tobacco vein banding mosaic virus and chilli veinal mottle virus infecting Solanum muricatum in China - Ning Jiang; Xiao-tong Gai; Zhong-long Lin; Can-hua Lu; Jun-hong Ma; Zhen-yuan Xia (Journal of Plant Pathology, 2022)

Ocean Currents May Influence the Endolithic Bacterial Composition in Coral Skeletons - Po-Yu Liu; Sung-Yin Yang; Chih-Ying Lu; Naohisa Wada; Stéphane De Palmas; Shu-Shuo Yeh; Hideyuki Yamashiro; Sen-Lin Tang; Shan-Hua Yang (Frontiers in Marine Science, 2022)
Coral endolithic microbes can be an important nutrients support for hosts while under stresses. Previous studies have found that the endolithic microbial composition of a single coral species can be biogeographical diverse. However, the potential environmental factors, such as salinity, temperature, pH, and nutrient, that might influence the composition of the endolithic microbes remain unclear. In this study, we used both amplicon sequence variants (ASV) and a kmer-based taxonomic unit (KTU) to characterize the endolithic bacterial constitution of Isopora spp. located in the western Pacific Ocean—where it is subjected to the Kuroshio Current (in Okinawa, Japan and Green Island, Taiwan)—and the South China Sea (Dongsha Atoll). The endolithic bacterial community compositions showed a significant geographical difference, and we suggest that the ocean current and primary productivity are the most essential environmental factors influencing the bacterial communities in the skeleton of Isopora spp. In addition, our results showed that, technically, compared to ASV, bacterial composition based on KTU avoids extreme data, making it a suitable tool for explaining the associations between microbes and environmental factors.

Follicular Fluid-Derived Exosomal MicroRNA-18b-5p Regulates PTEN-Mediated PI3K/Akt/mTOR Signaling Pathway to Inhibit Polycystic Ovary Syndrome Development - Zhi Zhou; Zhihua Tu; Juan Zhang; Can tan; Xiaoyong Shen; Bangbei Wan; Yejuan Li; Anguo Wang; Liqiang Zhao; Jiajia Hu; Ning Ma; Jing Zhou; et al. (Molecular Neurobiology, 2022)

The RNA-binding protein SND1 promotes the degradation of GPX4 by destabilizing the HSPA5 mRNA and suppressing HSPA5 expression, promoting ferroptosis in osteoarthritis chondrocytes - Min Lv; Yuanzhen Cai; Weikun Hou; Kan Peng; Ke Xu; Chao Lu; Wenxing Yu; Weisong Zhang; Lin Liu (Inflammation Research, 2022)

Lipoxin A4 regulates M1/M2 macrophage polarization via FPR2–IRF pathway - Jixiang Yuan; Feihong Lin; Lichen Chen; Weikang Chen; Xiaodong Pan; Yongheng Bai; Yong Cai; Hong Lu (Inflammopharmacology, 2022)

Genetic diversity and population structure of Curcuma alismatifolia Gagnep. accessions revealed by SSR markers - Hui-Wen Yu; Ling-Jun Ke; Yi-Lan Xiao; Si-Jia Chen; Yuan-Yuan Li; Qi-Lin Tian; Yun-He Li; Jin-Shui Lin; Luan-Mei Lu (Genetic Resources and Crop Evolution, 2022)

Correction to: Can “new infrastructure” reverse the “growth with pollution” profit growth pattern? An empirical analysis based on listed companies in China - Lu Qiao; Lin Li; Junjun Fei (Environmental Science and Pollution Research, 2022)

Can “new infrastructure” reverse the “growth with pollution” profit growth pattern? An empirical analysis based on listed companies in China - Lu Qiao; Lin Li; Junjun Fei (Environmental Science and Pollution Research, 2022)

Correction to: Coupling coordination analysis of China’s provincial water‑energy‑food nexus - Yingying Qi; Arash Farnoosh; Lu Lin; Hui Liu (Environmental Science and Pollution Research, 2022)

Coupling coordination analysis of China’s provincial water-energy-food nexus - Yingying Qi; Arash Farnoosh; Lu Lin; Hui Liu (Environmental Science and Pollution Research, 2022)

Autophagy of hepatic stellate cell induced by Clonorchis sinensis - Bao Zheng; Zhiyan Gao; Liumei Liang; Yunyu Lu; Yongting Kong; Wanting Chen; Keying Lin; Wanqi Chen; Jingying Mai; Yanwen Li; Changling Ma (Molecular Biology Reports, 2022)

Identification of epigenetic modifications mediating the antagonistic effect of selenium against cadmium-induced breast carcinogenesis - Zhuo-Zhi Liang; Yi-Xin Zhang; Rui-Mei Zhu; Yue-Lin Li; Hong-Mei Jiang; Ruo-Bi Li; Qian-Xin Chen; Qing Wang; Lu-Ying Tang; Ze-Fang Ren (Environmental Science and Pollution Research, 2022)

Sphingobacterium bovistauri sp. nov., Isolated from the Faeces of Bos Taurus - Qiong Wang; Zhi-Qin Fang; Chen-Lu Zhang; Jian-Qiang Shen; Jian-Dong Lai; Xiu-Lin Han; Tao Lu (Current Microbiology, 2022)

Consistency correction of echo intensity data for multiple radar systems and its application in quantitative estimation of typhoon precipitation - Shuai Zhang; Jing Han; Bingke Zhao; Zhigang Chu; Jie Tang; Limin Lin; Xiaoqin Lu; Jiaming Yan (Frontiers of Earth Science, 2022)

Genomic characterization of a new enamovirus infecting common bean - Ruo-bin Lu; Ping-xiu Lan; Ru-jing Kang; Guan-lin Tan; Xiao-jiao Chen; Ruhui Li; Fan Li (Archives of Virology, 2022)

Experimental study on drill bit torque influenced by artificial specimen mechanical properties and drilling parameters - Changzheng Lu; Wei Yang; Baiquan Lin (Arabian Journal of Geosciences, 2022)

Warming effects on grassland productivity depend on plant diversity - Junjiong Shao; Xuhui Zhou; Kees Jan van Groenigen; Guiyao Zhou; Huimin Zhou; Lingyan Zhou; Meng Lu; Jianyang Xia; Lin Jiang; Bruce A. Hungate; Yiqi Luo; Fangliang He; et al. (Global Ecology and Biogeography, 2022)
Aim Climate warming and biodiversity loss both alter plant productivity, yet we lack an understanding of how biodiversity regulates the responses of ecosystems to warming. In this study, we examine how plant diversity regulates the responses of grassland productivity to experimental warming using meta‐analytic techniques. Location Global. Major taxa studied Grassland ecosystems. Methods Our meta‐analysis is based on warming responses of 40 different plant communities obtained from 20 independent studies on grasslands across five continents. Results Our results show that plant diversity and its responses to warming were the most important factors regulating the warming effects on plant productivity, among all the factors considered (plant diversity, climate and experimental settings). Specifically, warming increased plant productivity when plant diversity (indicated by effective number of species) in grasslands was lower than 10, whereas warming decreased plant productivity when plant diversity was greater than 10. Moreover, the structural equation modelling showed that the magnitude of warming enhanced plant productivity by increasing the performance of dominant plant species in grasslands of diversity lower than 10. The negative effects of warming on productivity in grasslands with plant diversity greater than 10 were partly explained by diversity‐induced decline in plant dominance. Main conclusions Our findings suggest that the positive or negative effect of warming on grassland productivity depends on how biodiverse a grassland is. This may mainly be due to differences in how warming may affect plant dominance and subsequent shifts in interspecific interactions in grasslands of different plant diversity levels.

MoOpy2 is essential for fungal development, pathogenicity, and autophagy in Magnaporthe oryzae - Ying‐Ying Cai; Jing‐Yi Wang; Xi‐Yu Wu; Shuang Liang; Xue‐Ming Zhu; Lin Li; Jian‐Ping Lu; Xiao‐Hong Liu; Fu‐Cheng Lin (Environmental Microbiology, 2022)
Summary The development and pathogenicity of the fungus Magnaporthe oryzae , the causal agent of destructive rice blast disease, require it to perceive external environmental signals. Opy2, an overproduction‐induced pheromone‐resistant protein 2, is a crucial protein for sensing external signals in Saccharomyces cerevisiae . However, the biological functions of the homologue of Opy2 in M. oryzae are unclear. In this study, we identified that MoOPY2 is involved in fungal development, pathogenicity, and autophagy in M. oryzae . Deletion of MoOPY2 resulted in pleiotropic defects in hyphal growth, conidiation, germ tube extension, appressorium formation, appressorium turgor generation, and invasive growth, therefore leading to attenuated pathogenicity. Furthermore, MoOpy2 participates in the Osm1 MAPK pathway and the Mps1 MAPK pathway by interacting with the adaptor protein Mst50. The interaction sites of Mst50 and MoOpy2 colocalized with the autophagic marker protein MoAtg8 in the preautophagosomal structure sites (PAS). Notably, the Δ Moopy2 mutant caused cumulative MoAtg8 lipidation and rapid GFP‐MoAtg8 degradation in response to nitrogen starvation, showing that MoOpy2 is involved in the negative regulation of autophagy activity. Taken together, our study revealed that MoOpy2 of M. oryzae plays an essential role in the orchestration of fungal development, appressorium penetration, autophagy and pathogenesis.

Endosomal sorting complexes required for transport‐0 ( ESCRT ‐0) are essential for fungal development, pathogenicity, autophagy and ER ‐phagy in Magnaporthe oryzae - Li‐Xiao Sun; Hui Qian; Meng‐Yu Liu; Ming‐Hua Wu; Yun‐Yun Wei; Xue‐Ming Zhu; Jian‐Ping Lu; Fu‐Cheng Lin; Xiao‐Hong Liu (Environmental Microbiology, 2022)
Summary Magnaporthe oryzae is an important plant pathogen that causes rice blast. Hse1 and Vps27 are components of ESCRT‐0 involved in the multivesicular body (MVB) sorting pathway and biogenesis. To date, the biological functions of ESCRT‐0 in M. oryzae have not been determined. In this study, we identified and characterized Hse1 and Vps27 in M. oryzae . Disruption of MoHse1 and MoVps27 caused pleiotropic defects in growth, conidiation, sexual development and pathogenicity, thereby resulting in loss of virulence in rice and barley leaves. Disruption of MoHse1 and MoVps27 triggered increased lipidation of MoAtg8 and degradation of GFP‐MoAtg8, indicating that ESCRT‐0 is involved in the regulation of autophagy. ESCRT‐0 was determined to interact with coat protein complex II (COPII), a regulator functioning in homeostasis of the endoplasmic reticulum (ER homeostasis), and disruption of MoHse1 and MoVps27 also blocked activation of the unfolded protein response (UPR) and autophagy of the endoplasmic reticulum (ER‐phagy). Overall, our results indicate that ESCRT‐0 plays critical roles in regulating fungal development, virulence, autophagy and ER‐phagy in M. oryzae .

Anti-proliferative cassane-type diterpenoids from the seeds of Caesalpinia minax - Yunshao Xu; Wei Shi; Lu Feng; Jun Cao; Zheling Feng; Qingwen Zhang; Jinjian Lu; Yang Ye; Ligen Lin (Natural Product Research, 2022)

A First Insight Into the Heat-Induced Changes in Proteomic Profiles of the Coral Symbiotic Bacterium Endozoicomonas montiporae - Ya-Fan Chan; Chia-Yu Chen; Chih-Ying Lu; Yung-Chi Tu; Kshitij Tandon; Shinya Shikina; Sen-Lin Tang (Frontiers in Marine Science, 2022)
Endozoicomonas , a core bacterial group in corals, may also be a coral symbiont. Endozoicomonas communities often decrease rapidly in corals under heat stress. However, how the bacteria respond to changes in temperature and coral host during heat stress is unknown. Here, we employed the cultivable, dominant species E. montiporae as a working organism to explore how Endozoicomonas responds to heat stress. We designed two experiments to clarify the extent to which E. montiporae is influenced by temperature and coral host. We detected differentially expressed protein (DEP) profiles in this bacterium at 31 and 33°C compared to 25°C by tandem mass tags-based quantitative proteome analysis. Fifty DEPs, including many heat shock proteins, were detected when the temperature changed. The expression of antioxidant defense proteins and key pyruvate synthase proteins decreased, suggesting that E. montiporae were in a physiology of stress at 33°C. Furthermore, some proteins were differentially expressed because of the heat-stress-treated coral lysate specifically, suggesting that not only heat but also heat-induced host factors can affect the protein expression of the bacterium. This study provides an in-depth analysis of how the molecular mechanisms of Endozoicomonas are affected by heat stress and coral host.

Fishery Dynamics, Status, and Rebuilding Based on Catch-Only Data in Coastal Waters of China - Linlong Wang; Li Lin; Yang Liu; Lu Zhai; Shen Ye (Frontiers in Marine Science, 2022)
China has become the largest contributor to marine fisheries in the world with its fishing fleets explosively increasing their fishing effort and resulting catch, but its fishery composition and sustainability have deteriorated. Limited information on fishery exploitation status encumbers effective resource management. In this study, a data-poor Monte Carlo method, the Catch-Maximum Sustainable Yield (CMSY) method, was used to estimate the historical exploited dynamics and current stock status of ten Chinese economic marine fish stocks, including Trichiurus lepturus , Larimichthys crocea , Larimichthys polyactis , Thamnaconus modestus , Scomberomorus niphonius , Ilisha elongate , Decapterus maruadsi , Scomber japonicus , Engraulis japonicus , and Clupea pallasii , which accounted for about 50% of total fish catches in the coastal waters of China and covered five functional groups (i.e., large, medium benthopelagic, large, medium, and small pelagic). Species L. crocea and L. polyactis had been subjected to overfishing since the 1950s. The others showed a decreasing trend in biomass along with the explosively increasing fishing efforts since the 1990s. Benthopelagic fish experienced overfishing pressure about a decade earlier than pelagic species. All the fish stocks investigated in this study were depleted (current biomass lower than the biomass capable of producing maximum sustainable yields, i.e., B < B msy ) in 2019, and most species were still facing high-fishing pressure (current fishing mortality higher than the mortality capable of producing maximum sustainable yields, i.e., F > F msy ). Also, a Schaefer model was used to assess stocks rebuilding status until 2030 under four exploitation scenarios, i.e., fishing mortality equals 0.5, 0.6, 0.8, or 0.95 times F msy . Most species stocks will likely recover to the B msy , which indicates that reduction of fishing pressure is probably the most effective way for fishery recovery.

Downregulated Calcium-Binding Protein S100A16 and HSP27 in Placenta-Derived Multipotent Cells Induce Functional Astrocyte Differentiation - Yu-Che Cheng; Chi-Jung Huang; Wei-Chi Ku; Shu-Lin Guo; Lu-Tai Tien; Yih-Jing Lee; Chih-Cheng Chien (Stem Cell Reviews and Reports, 2022)
Little is known about genes that induce stem cells differentiation into astrocytes. We previously described that heat shock protein 27 (HSP27) downregulation is directly related to neural differentiation under chemical induction in placenta-derived multipotent stem cells (PDMCs). Using this neural differentiation cell model, we cross-compared transcriptomic and proteomic data and selected 26 candidate genes with the same expression trends in both omics analyses. Those genes were further compared with a transcriptomic database derived from Alzheimer’s disease (AD). Eighteen out of 26 candidates showed opposite expression trends between our data and the AD database. The mRNA and protein expression levels of those candidates showed downregulation of HSP27, S100 calcium-binding protein A16 (S100A16) and two other genes in our neural differentiation cell model. Silencing these four genes with various combinations showed that co-silencing HSP27 and S100A16 has stronger effects than other combinations for astrocyte differentiation. The induced astrocyte showed typical astrocytic star-shape and developed with ramified, stringy and filamentous processes as well as differentiated endfoot structures. Also, some of them connected with each other and formed continuous network. Immunofluorescence quantification of various neural markers indicated that HSP27 and S100A16 downregulation mainly drive PDMCs differentiation into astrocytes. Immunofluorescence and confocal microscopic images showed the classical star-like shape morphology and co-expression of crucial astrocyte markers in induced astrocytes, while electrophysiology and Ca 2+ influx examination further confirmed their functional characteristics. In conclusion, co-silencing of S100A16 and HSP27 without chemical induction leads to PDMCs differentiation into functional astrocytes. Graphical abstract

Genome-wide analysis of BURP genes and identification of a BURP-V gene RcBURP4 in Rosa chinensis - Lufeng Fu; Zhujun Zhang; Hai Wang; Xiaojuan Zhao; Lin Su; Lifang Geng; Yizeng Lu; Boqiang Tong; Qinghua Liu; Xinqiang Jiang (Plant Cell Reports, 2022)

CRISPR-Cas9-Mediated Gene Therapy in Neurological Disorders - Lihong Guan; Yawei Han; Ciqing Yang; Suxiang Lu; Jiang Du; Han Li; Juntang Lin (Molecular Neurobiology, 2022)

Video target detection of East Asian migratory locust based on the MOG2-YOLOv4 network - Zhao Bai; Zhan Tang; Lei Diao; Shuhan Lu; Xuchao Guo; Han Zhou; Chengqi Liu; Lin li (International Journal of Tropical Insect Science, 2022)

ARRDC3 polymorphisms may affect the risk of glioma in Chinese Han - Nan Li; Hangyu Shi; Pengfei Hou; Lu Gao; Yongqiang Shi; Weiyang Mi; Gang Zhang; Ning Wang; Wei Dai; Lin Wei; Tianbo Jin; Yongzhi Shi; et al. (Functional & Integrative Genomics, 2022)

A bibliometric review of peripartum cardiomyopathy compared to other cardiomyopathies using artificial intelligence and machine learning - M. Grosser; H. Lin; M. Wu; Y. Zhang; S. Tipper; D. Venter; J. Lu; C. G. dos Remedios (Biophysical Reviews, 2022)

The Flavor and Antioxidant Activity Change Pattern of Shrimp Head Paste During Fermentation - Jing Yu; Kuan Lu; Jinyuan Sun; Wancui Xie; Lin Song; Hongxia Che (Journal of Ocean University of China, 2022)

Identification and Expression Analysis of miR160 and Their Target Genes in Cucumber - Yaoyao Li; Weirong Luo; Yongdong Sun; Huaicheng Chang; Kai Ma; Zhenxiang Zhao; Lin Lu (Biochemical Genetics, 2022)

Advenella mandrilli sp. nov., a bacterium isolated from the faeces of Mandrillus sphinx - Qiong Wang; Xiu-Lin Han; Zhi-Qin Fang; Chen-Lu Zhang; Chun Li; Tao Lu (Antonie van Leeuwenhoek, 2022)

Dietary nutrients shape gut microbes and intestinal mucosa via epigenetic modifications - Jianmin Wu; Ying Zhao; Xian Wang; Lingchang Kong; Lee J. Johnston; Lin Lu; Xi Ma (Critical Reviews in Food Science and Nutrition, 2022)

Water Temperature at Different Depths Affects the Distribution of Neon Flying Squid (Ommastrephes bartramii) in the Northwest Pacific Ocean - Jintao Wang; Yiqi Cheng; Huajie Lu; Xinjun Chen; Lei Lin; Junbo Zhang (Frontiers in Marine Science, 2022)
Ommastrephes bartramii can vertically swim during its life, and previous studies have suggested the need to account for preferred habitat distribution influenced by water temperatures at different depths. To explore the impacts of deep-water temperature on O. bartramii spatial distribution, we constructed generalized additive models (GAMs) based on the Chinese squid-jigging fishery data and the Argo deep water temperature data during 2005–2018 in the Northwest Pacific Ocean to analyze the relationships between the local abundance of O. bartramii and deep-water temperatures. The results showed that the variables including surface water temperature ( T 0 ), water temperature at 30- and 100-m depths ( T 30 and T 100 ), and water differences between T 0 and T 30 ( D 0–30 ) significantly affected the spatial distribution of O. bartramii . The suitable ranges of each variable are different, > 15.5°C for T 0 , 11–18°C for T 30 , < 6°C for T 100 , and 4–4.5°C for D 0–30 . The areas occupied by the suitable T 30 seemed to reflect the outline of fishing ground, whereas the areas with suitable T 100 were to indicate the high density of O. bartramii . The predicted suitable habitat area and high-density area for O. bartramii are also regulated by El Niño–Southern Oscillation (ENSO) events. We demonstrated how the estimates of O. bartramii spatial distribution would vary influenced by deep-water temperatures in the Northwest Pacific Ocean. This information may help develop an appropriate method for investigating the effects of deep-water temperature on species with vertical migration.

Isolation and structural elucidation of a low-molecular-weight polysaccharide from the roots of Panax ginseng C. A. Meyer - Bin Zhao; Xin-Ying Wang; Wen Luo; Yue Lin; Chong-Ning Lv; Jin-Cai Lu (Natural Product Research, 2022)

Two new triterpenoid-chromone hybrids from the rhizomes of Actaea cimicifuga L. (syn. Cimicifuga foetida L.) and their cytotoxic activities - Qiang-Qiang Shi; Ya Gao; Jing Lu; Lin Zhou; Ming-Hua Qiu (Natural Product Research, 2022)

New paraconic acids from the endophytic fungus Xylariaceae sp. J4 - Chao Yuan; Xue-Chun Shu; Lin Fan; Ying-Bo Zhang; Ling-Liang Guan; Fu-Lai Yu; Xiao-Lu Chen; Gang Li (Natural Product Research, 2022)

BMAL1 induces colorectal cancer metastasis by stimulating exosome secretion - Pengjuan Dong; Yaping Wang; Yutong Liu; Chunting Zhu; Jiaxin Lin; Ruizhe Qian; Luchun Hua; Chao Lu (Molecular Biology Reports, 2022)

Identification of Novel Nonapeptides from Sipunculus nudus L. and Comparing Its ACEI Activities Mechanism by Molecular Docking - Yi Qi; Xiaoning Tang; Huan Liu; Qianxing Lin; Yingnian Lu; Hui Luo (International Journal of Peptide Research and Therapeutics, 2022)

PHD2 attenuates high-glucose-induced blood retinal barrier breakdown in human retinal microvascular endothelial cells by regulating the Hif-1α/VEGF pathway - Jia Li; Xi Lu; Liqing Wei; Dan Ye; Jianqiang Lin; Xiaoyu Tang; Kaixuan Cui; Shanshan Yu; Yue Xu; Xiaoling Liang (Inflammation Research, 2022)

The difference in the intracellular Arg/Lys-rich and EHLVY motifs contributes to distinct subcellular distribution of HAI-1 versus HAI-2 - Nanxi Huang; Robert B. Barndt; Dajun D. Lu; Qiaochu Wang; Shih-Ming Huang; Jehng-Kang Wang; Ping-Ying Chang; Chao-Yang Chen; Je-Ming Hu; Hui-Chen Su; Michael D. Johnson; Chen-Yong Lin (Human Cell, 2022)

Overexpression of long noncoding RNA MCM3AP-AS1 promotes osteogenic differentiation of dental pulp stem cells via miR-143-3p/IGFBP5 axis - Changwei Yang; Xuehong Xu; Pingting Lin; Bizhu Luo; Shufang Luo; Honglan Huang; Jianyu Zhu; Meie Huang; Shuhai Peng; Qianju Wu; Lu Yin (Human Cell, 2022)

Evolutionary game analysis of coal enterprise resource integration under government regulation - Ziyuan Sun; Wei Wang; Weixing Zhu; Lin Ma; Yuting Dong; Jiangwei Lu (Environmental Science and Pollution Research, 2022)

Adenine base-editing-mediated exon skipping induces gene knockout in cultured pig cells - Xiang-xing Zhu; Jia-sheng Pan; Tao Lin; Ye-cheng Yang; Qiu-yan Huang; Shuai-peng Yang; Zi-xiao Qu; Zi-sheng Lin; Jian-cong Wen; Ai-fen Yan; Juan Feng; Lian Liu; et al. (Biotechnology Letters, 2022)

A novel alphahypovirus that infects the fungal plant pathogen Sclerotinia sclerotiorum - Weibo Liang; Zhongbo Lu; Jie Duan; Daohong Jiang; Jiatao Xie; Jiasen Cheng; Yanping Fu; Tao Chen; Bo Li; Xiao Yu; Weidong Chen; Yang Lin (Archives of Virology, 2022)

Sabulicella rubraurantiaca gen. nov., sp. nov., a new member of the family Acetobacteraceae, isolated from desert soil - Zhi-Liang Lin; Shuai Li; Qi-Chuang Wei; Wen-Hui Lian; Chun-Yan Lu; Lu Xu; Li-Nan Huang; Lei Dong; Wen-Jun Li (Archives of Microbiology, 2022)

FY-3E: The First Operational Meteorological Satellite Mission in an Early Morning Orbit - Peng Zhang; Xiuqing Hu; Qifeng Lu; Aijun Zhu; Manyun Lin; Ling Sun; Lin Chen; Na Xu (Advances in Atmospheric Sciences, 2022)

Kinetics and Size Effects on Adsorption of Cu(II), Cr(III), and Pb(II) Onto Polyethylene, Polypropylene, and Polyethylene Terephthalate Microplastic Particles - Xiaoxin Han; Shiyu Wang; Xue Yu; Rolf D. Vogt; Jianfeng Feng; Lifang Zhai; Weiqi Ma; Lin Zhu; Xueqiang Lu (Frontiers in Marine Science, 2021)
Due to its small size, large specific surface area and hydrophobicity, microplastics, and the adsorbed contaminants may together cause potential negative effects on ecosystems and human beings. In this study, kinetics and size effects on adsorption of Cu(II), Cr(III), and Pb(II) onto PE, PP and PET microplastic particles were explored. Results indicated that the PE and PET microplastics have the higher adsorption capacity for Cu(II), Cr(III), and Pb(II) than that for PP microplastic. The adsorption capacity was affected by microplastic types and metal species. Among the three metals, Pb(II) had the largest adsorption amount on microplastic particles, especially on PET particles. Moreover, the adsorption capacities of microplastics increase with the decrease of particle size. The metal adsorption capacity of <0.9 mm microplastics is greater than that of 0.9–2 mm and 2–5 mm microplastics. The size effect on metal adsorption was largest for PE microplastic. More attention should be paid in case of the coexistence of heavy metals and tiny PE and PET microplastics in the environment.

Environmental consequences of an ultra-low emission retrofit in coal-fired power plants from a life cycle perspective - Jun Dong; Yuanjun Tang; Aizhong Ruan; Jie Chen; Xiaoqing Lin; Shengyong Lu; Xiang Gao (Waste Disposal & Sustainable Energy, 2021)

Genetic dissection of a pericentromeric region of barley chromosome 6H associated with Fusarium head blight resistance, grain protein content and agronomic traits - Yadong Huang; Lu Yin; Ahmad H. Sallam; Shane Heinen; Lin Li; Karen Beaubien; Ruth Dill-Macky; Yanhong Dong; Brian J. Steffenson; Kevin P. Smith; Gary J. Muehlbauer (Theoretical and Applied Genetics, 2021)

Analysis of the thaumatin-like genes of Rosa chinensis and functional analysis of the role of RcTLP6 in salt stress tolerance - Lin Su; Xiaojuan Zhao; Lifang Geng; Lufeng Fu; Yizeng Lu; Qinghua Liu; Xinqiang Jiang (Planta, 2021)

A comparison of atmospheric geochemistry through lichens from volcanic and non-volcanic areas, north Taiwan - Le-Qi Lin; Hsueh-Yu Lu; Ju-Lien Pi; Tai-Sheng Liou; Wen-Fu Chen; Pei-Shan Hsieh (Journal of Earth System Science, 2021)

Hypoosmotic stress induced functional alternations of intestinal barrier integrity, inflammatory reactions, and neurotransmission along gut-brain axis in the yellowfin seabream (Acanthopagrus latus) - Genmei Lin; Shizhu Li; Junrou Huang; Dong Gao; Jianguo Lu (Fish Physiology and Biochemistry, 2021)

Continental-scale spatial distribution, sources, and health risks of heavy metals in seafood: challenge for the water-food-energy nexus sustainability in coastal regions? - Jian Lu; Yichen Lin; Jun Wu; Cui Zhang (Environmental Science and Pollution Research, 2021)

Experimental study on the discharge characteristics of viscous debris flow with grid-type dam - Jinfeng Liu; Dong Yuan; Ming Lu; Yong You; Guangze Zhang; Tao Feng; Dong Wang; Zhiheng Lin (Environmental Fluid Mechanics, 2021)

Releasing Characteristics and Biological Toxicity of the Heavy Metals from Waste of Mercury-Thalliummine in Southwest Guizhou of China - Jichang Wen; Yonggui Wu; Qian Lu; Xinlong Li; Lin Yang; Zhibin Duan (Bulletin of Environmental Contamination and Toxicology, 2021)

Generation and characterization of a Myh6-driven Cre knockin mouse line - Xinyan Huang; Lei Yan; Shan Kou; Jufeng Meng; Zhengkai Lu; Chao-Po Lin; Chen Liu; Hui Zhang (Transgenic Research, 2021)
Gene deletion by the Cre-Loxp system has facilitated functional studies of many critical genes in mice, offering important insights and allowing deeper understanding on the mechanisms underlying organ development and diseases, such as heart development and diseases. In this study, we generated a Myh6-Cre knockin mouse model by inserting the IRES-Cre-wpre-polyA cassette between the translational stop codon and the 3′ untranslated region of the endogenous Myh6 gene. By crossing knockin mice with the Rosa26 reporter lines, we found that Myh6-Cre targeted cardiomyocytes at the embryonic and postnatal stages. In addition, we were able to inactivate the desmosome gene Desmoplakin (Dsp) by breeding Myh6-Cre mice with a conditional Dsp flox knockout mouse line, which resulted in embryonic lethality during the mid-term pregnancy. These results suggest that the new Myh6-Cre mouse line can serve as a robust tool to dissect the distinct roles of genes involved in heart development and function.

Bioinformatics-based study to identify immune infiltration and inflammatory-related hub genes as biomarkers for the treatment of rheumatoid arthritis - Sheng Fang; Xin Xu; Lin Zhong; An-quan Wang; Wei-lu Gao; Ming Lu; Zong-Sheng Yin (Immunogenetics, 2021)

Complete genome sequence of a putative novel ilarvirus isolated from Eleocharis dulcis - Lanqing Lv; Xinyang Wu; Jiajia Weng; Yuchao Lai; Kelei Han; Yuwen Lu; Jiejun Peng; Lin Lin; Shaofei Rao; Guanwei Wu; Jianping Chen; Hongying Zheng; et al. (Archives of Virology, 2021)

Characterization and identification of SFDC ‐1, a novel AmpC ‐type β‐lactamase in Serratia fonticola - Xu Dong; Peiyao Zhang; Kexin Zhou; Jialei Liang; Qiaoling Li; Xueya Zhang; Danying Zhou; Wei Lu; Zhewei Sun; Hongmao Liu; Junwan Lu; Xi Lin; et al. (Environmental Microbiology, 2021)
Summary The clinical and environmental infections caused by AmpC β‐lactamases have been increasingly reported recently. In this study, we characterize the novel chromosome‐encoded AmpC β‐lactamase SFDC‐1 identified in Serratia fonticola strain R28, which was isolated from a rabbit raised on a farm in southern China. SFDC‐1 shared the highest amino acid identity of 79.6% with the functionally characterized AmpC β‐lactamase gene bla YRC‐1 , although it had highly homologous functionally uncharacterized relatives in the same species from different sources, including some of the clinical significance. The cloned bla SFDC‐1 exhibited resistance to a broad spectrum of β‐lactam antibiotics, including most cephalosporins with the highest resistance to ampicillin, cefazolin and ceftazidime, with increased MIC levels ≥128‐fold compared with the control strains. The purified SFDC‐1 showed catalytic activities against β‐lactams with the highest catalytic activity to cefazolin. The genetic context of bla SFDC‐1 and its relatives was conserved in the chromosome, and no mobile genetic elements were found surrounding them.

Conservation planning on China's borders with Myanmar, Laos, and Vietnam - Lin Wang; Bin Yang; Yang Bai; Xiaoqiang Lu; Richard T. Corlett; Yunhong Tan; Xiao‐Yong Chen; Jianguo Zhu; Yan Liu; Rui‐Chang Quan (Conservation Biology, 2021)
Transboundary conservation is playing an increasingly important role in maintaining ecosystem integrity and halting biodiversity loss caused by anthropogenic activities. However, lack of information on species distributions in transboundary regions and understanding of the threats in these areas impairs conservation. We developed a spatial conservation plan for the transboundary areas between Yunnan province, southwestern China, and neighboring Myanmar, Laos, and Vietnam in the Indo‐Burma biodiversity hotspot. To identify priority areas for conservation and restoration, we determined species distribution patterns and recent land‐use changes and examined the spatiotemporal dynamics of the connected natural forest, which supports most species. We assessed connectivity with equivalent connected area (ECA), which is the amount of reachable habitat for a species. An ECA incorporates the presence of habitat in a patch and the amount of habitat in other patches within dispersal distance. We analyzed 197,845 locality records from specimen collections and monographs for 21,004 plant and vertebrate species. The region of Yunnan immediately adjacent to the international borders had the highest species richness, with 61% of recorded species and 56% of threatened vertebrates, which suggests high conservation value. Satellite imagery showed the area of natural forest in the border zone declined by 5.2% (13,255 km 2 ) from 1995 to 2018 and monoculture plantations increased 92.4%, shrubland 10.1%, and other cropland 6.2%. The resulting decline in connected natural forest reduced the amount of habitat, especially for forest specialists with limited dispersal abilities. The most severe decline in connectivity was along the Sino‐Vietnamese border. Many priority areas straddle international boundaries, indicating demand and potential for establishing transboundary protected areas. Our results illustrate the importance of bi‐ and multilateral cooperation to protect biodiversity in this region and provide guidance for future conservation planning and practice.

Mackerel (Scomber australasicus) Reproduction in Northeastern Taiwan - Sunarti Sinaga; Hsueh-Jung Lu; Jia-Rong Lin (Journal of Marine Science and Engineering, 2021)
Blue mackerel (Scomber australasicus) is a crucial target species for coastal fisheries in Taiwan, and additionally it has maintained its status as the highest-produced species. The timely measurement of spawning status is crucial for determining the correct management strategy for this species. The objective of this study was to determine size at maturity, fecundity, batch fecundity, and spawning frequency on the basis of samples collected from Nan-Fang-Ao fishing port in Yilan, during the spawning season from 2017 to 2019. Histological sections indicated that the blue mackerel were multiple spawners; a higher percentage of female fish spawned at the peak of the gonadosomatic index. The 50% sizes at maturity were 32.02, 32.13, and 29.64 cm. Mean total fecundity (batch fecundity) was 165 (103), 229 (96), and 210 (68) oocytes per ovary-free weight (g) for 2017, 2018, and 2019, respectively; fecundity was determined through observation of postovulatory follicles (POFs). The spawning frequencies (spawning fraction) in 2017, 2018, and 2019 were 3–10 days (0.13), 4–14 days (0.08), and 4–12 days (0.09), respectively. The spawning frequencies determined through the three estimated methods, namely the sums of (a) hydrated and Day 0 POFs; (b) Day 1+ POFs, and (c) all data combined, were 1 spawning event per 8, 10, and 9 days, respectively. The reproduction of the blue mackerel was greater in 2017 than it was in 2018 or 2019, as indicated by the higher batch fecundity and shorter spawning seasons. Environmental factors should also be considered as a major factor influencing successful reproduction and spawning season

Surface Chlorophyll-A Fronts in the Yellow and Bohai Seas Based on Satellite Data - Lu Xia; Hao Liu; Lei Lin; Yueqi Wang (Journal of Marine Science and Engineering, 2021)
Chlorophyll fronts are important to monitor and map the oceanic front, especially in the season when sea surface temperature (SST) fronts weaken. In this study, surface chlorophyll-a (chl-a) fronts in the Yellow and Bohai seas were characterized for the first time using satellite data. Five distinct chl-a fronts (i.e., the Bohai Strait, Shandong Peninsula, Jiangsu, Liaodong Peninsula, and Korean Peninsula fronts) were observed in summer along the 40 m isobaths and faded in other seasons. Notably, these fronts coincided with SST fronts. Strong chl-a fronts emerged during summer due to chl-a blooms in eutrophic coastal waters paired with surface chl-a fading in strongly stratified offshore waters and coastal physical fronts. Although SST fronts were strong during winter, light limitation and strong vertical mixing in offshore waters led to low chl-a in both coastal and offshore waters, suppressing chl-a front formation. Both chl-a and SST fronts coincided with steep seabed slopes (slope ratio > 1), suggesting that seabed slope may be an indicator of oceanic front location.

Experimental and Numerical Investigations of Reinforced Soil Wall Subjected to Impact Loading - Liang Lu; Haoxin Lin; Zongjian Wang; Liang Xiao; Shuwen Ma; Katsuhiko Arai (Rock Mechanics and Rock Engineering, 2021)

Dopaminergic Projection from Ventral Tegmental Area to Substantia Nigra Pars Reticulata Mediates Chronic Social Defeat Stress–Induced Hypolocomotion - Feng He; Pei Zhang; Qian Zhang; Guangjian Qi; Hongwei Cai; Tongxia Li; Ming Li; Jiazhen Lu; Jiaen Lin; Jie Ming; Bo Tian (Molecular Neurobiology, 2021)

First report of black leaf mold by Cladosporium tenuissimum on Paulownia fortunei - Liu Yuelian; Zhong Feiteng; Lu Shili; Chen Jie; Lin Pinling; Lin Xiao; Jiang Hongbin; Zhang Xuhong (Journal of Plant Pathology, 2021)

Evaluating the energy, health efficiency, and productivity in OECD - Ching-Cheng Lu; Yung-ho Chiu; Chih-Yu Yang; Tai-Yu Lin (Environmental Geochemistry and Health, 2021)

Pseudomonas nanhaiensis sp. nov., a lipase-producing bacterium isolated from deep-sea sediment of the South China Sea - Yu Pang; Yage Zhang; Mengru Chen; Wei Lu; Ming Chen; Yongliang Yan; Min Lin; Wei Zhang; Zhengfu Zhou (Antonie van Leeuwenhoek, 2021)

The Regulatory Relationships Between the Gonad-Inhibiting Hormone and Insulin-Like Androgenic Gland Hormone-Binding Protein Genes in the Eyestalk-Androgenic Gland-Testis Axis of Macrobrachium rosenbergii - Meizhen Tang; Zhijie Lu; Sarath V Babu; Guang Yang; Yanan Li; Zizheng Xu; Gan Pan; Zhendong Qin; Li Lin (Frontiers in Marine Science, 2021)
Gonad-inhibiting hormone (GIH) belongs to a family of neuropeptides that are released from the eyestalks of male crustaceans and plays key roles in gonadal maturity, reproduction, and molting. However, the detailed mechanisms underlying the effects of GIH on sexual regulation have yet to be elucidated. In the present study, we aimed to demonstrate how GIH mediate the activity of the androgenic gland (AG) to affect sexual regulation. To do this, we cloned and characterized a GIH sequence from Macrobrachium rosenbergii ( Mr GIH). The open reading frame (ORF) of Mr GIH was 360 bp and codes for a polypeptide of 119 amino acids and a putative protein of 13.56 KDa. Tissue analysis showed that Mr GIH is widely expressed in a range of tissues but particularly, the eyestalk, intestine, and nerve cord. Following the ds RNA silencing of Mr GIH for 24 h, the expression levels of Mr GIH were down-regulated in both the eyestalk and AG when compared with the negative control, but significantly increased the expression of Macrobrachium rosenbergii insulin-like androgenic gland hormone-binding protein ( Mr IAGBP) in AG, thus suggesting that Mr GIH is an inhibitory factor for Mr IAGBP. In addition, we found that eyestalk removal on certain days led to increased expression levels of Mr IAGBP expression. The expression levels of Mr IAGBP peaked at 2 d in the AG after unilateral and bilateral eyestalk ablation, exhibiting a 7.27- and 6.03-fold increase, respectively. Afterward, the expression of GIH protein levels were down-regulated and IAGBP protein levels were up-regulated after GIH silencing using immunohistochemistry method, combined with the increase of IAGBP protein levels after eyestalk ablation, confirming that Mr GIH is an inhibitory factor that can moderately regulate AG development and IAGBP expression. Collectively, our findings enriched the mechanisms that control the sexual regulation pathway of male M. rosenbergii , and provided significant information for further explorations of the mechanism underlying sex regulation in other decapod crustaceans.

A new abietane diterpene and anti-complementary constituents from Juniperus tibetica - Dong-Lin Zeng; Chang-Yue Wang; Hui-Qin Gao; Dao-Feng Chen; Yan Lu (Natural Product Research, 2021)

Anti-miR33 therapy improved hepatopancreatic lipid and immune metabolism disorders in grass carp, Ctenopharyngodon idella - Rong-Hua Lu; Meng-Jun Lin; Feng Yang; Shen-zong Jia; Yu-Ru Zhang; Chao-Bin Qin; Xiao-Lin Meng; Guo-Xing Nie (Fish Physiology and Biochemistry, 2021)

Investigation and disinfection of bacteria and fungi in sports fitness center - Nonglak Boonrattanakij; Sirikorn Yomchinda; Fang-Jia Lin; Luzvisminda M. Bellotindos; Ming-Chun Lu (Environmental Science and Pollution Research, 2021)

Comparison of the elimination effectiveness of tetracycline and AmpC β-lactamase resistance genes in a municipal wastewater treatment plant using four parallel processes - Xiaojun Lin; Jingjing Ruan; Lu Huang; Jianbin Zhao; Yanbin Xu (Ecotoxicology, 2021)

An efficient genetic manipulation protocol for dark septate endophyte Falciphora oryzae - Zhen-Zhu Su; Meng-Di Dai; Jia-Nan Zhu; Yu-Lan Zeng; Xuan-Jun Lu; Xiao-Hong Liu; Fu-Cheng Lin (Biotechnology Letters, 2021)

Shared and specific patterns of structural and functional thalamo-frontal disturbances in manic and euthymic pediatric bipolar disorder - Yi-Bing Guo; Wei-Jia Gao; Zhi-Liang Long; Wei-Fang Cao; Dong Cui; Yong-Xin Guo; Qing Jiao; Jian-Feng Qiu; Lin-Yan Su; Guang-Ming Lu (Brain Imaging and Behavior, 2021)
Bipolar disorder (BD) is clinically defined by alternating depressive and manic episodes with a separated period of euthymia. Thalamo-frontal loop plays vital role in psychotic symptoms, altered motor control and executive difficulties in BD. It remains unclear that structural and functional alterations of thalamo-frontal loop among the different mood states in BD, especially in pediatric BD(PBD). Twenty manic PBD (mPBD), 20 euthymic PBD (ePBD) and 19 healthy controls (HCs) were included in the study. By analyzing the T1 images and fMRI signals, thalamus volume and frontal grey matter cortical thickness were tested, and functional connectivity (FC) between bilateral thalamus and frontal cortex was calculated. Relationship between clinical indices and thalamo-frontal FC was also evaluated in mPBD and ePBD adolescents. Compared to HCs, the cortical thickness of left middle frontal gyrus (MFG), bilateral superior frontal gyrus (SFG) was significantly decreased in both mPBD and ePBD patients, and volume of left thalamus and cortical thickness of right MFG significantly decreased in mPBD patients. Compared to that of the HCs and ePBD subjects, thalamo-frontal hyperconnectivity with MFG was found in mPBD, and compared with that of HCs, thalamo-frontal hypoconnectivity with precentral gyrus/SFG was found in ePBD. In ePBD patients, episode times positively correlated with FC values between thalamus and precentral gyrus. The findings of the present study demonstrate detailed knowledge regarding shared and specific structural and functional disruption in thalamo-frontal loop in mPBD and ePBD subjects. Thalamo-frontal abnormalities reported in adult BD subjects were also observed in adolescent BD patients, and thalamo-frontal dysfunction may be a crucial treatment target in BD.

Ambient climate determines the directional trend of community stability under warming and grazing - Peipei Liu; Wangwang Lv; Jianping Sun; Caiyun Luo; Zhenhua Zhang; Xiaoxue Zhu; Xingwu Lin; Jichuang Duan; Guangping Xu; Xiaofeng Chang; Yigang Hu; Qiaoyan Lin; et al. (Global Change Biology, 2021)
Changes in ecological processes over time in ambient treatments are often larger than the responses to manipulative treatments in climate change experiments. However, the impacts of human‐driven environmental changes on the stability of natural grasslands have been typically assessed by comparing differences between manipulative plots and reference plots. Little is known about whether or how ambient climate regulates the effects of manipulative treatments and their underlying mechanisms. We collected two datasets, one a 36‐year long‐term observational dataset from 1983 to 2018, and the other a 10‐year manipulative asymmetric warming and grazing experiment using infrared heaters with moderate grazing from 2006 to 2015 in an alpine meadow on the Tibetan Plateau. The 36‐year observational dataset shows that there was a nonlinear response of community stability to ambient temperature with a positive relationship between them due to an increase in ambient temperature in the first 25 years and then a decrease in ambient temperature thereafter. Warming and grazing decreased community stability with experiment duration through an increase in legume cover and a decrease in species asynchrony, which was due to the decreasing background temperature through time during the 10‐year experiment period. Moreover, the temperature sensitivity of community stability was higher under the ambient treatment than under the manipulative treatments. Therefore, our results suggested that ambient climate may control the directional trend of community stability while manipulative treatments may determine the temperature sensitivity of the response of community stability to climate relative to the ambient treatment. Our study emphasizes the importance of the context dependency of the response of community stability to human‐driven environmental changes.

The mechanism and application of bidirectional extracellular electron transport in the field of energy and environment - Qingqing Xie; Yue Lu; Lin Tang; Guangming Zeng; Zhaohui Yang; Changzheng Fan; Jingjing Wang; Siavash Atashgahi (Critical Reviews in Environmental Science and Technology, 2021)

MS1 is essential for male fertility by regulating the microsporocyte cell plate expansion in soybean - Xiaolong Fang; Xiaoyuan Sun; Xiangdong Yang; Qing Li; Chunjing Lin; Jie Xu; Wenjun Gong; Yifan Wang; Lu Liu; Limei Zhao; Baohui Liu; Jun Qin; et al. (Science China Life Sciences, 2021)

Efficiently immobilizing uranium (VI) by oxidized carbon foam - Hongliang Bao; Chunyu Xie; Ling Han; Zenghui Yue; Yuan Qian; Linjuan Zhang; Zi-Jian Li; Huangjie Lu; Jian Lin; Jian-Qiang Wang (Environmental Science and Pollution Research, 2021)

Application of the modified cytosine base-editing in the cultured cells of bama minipig - Jia-sheng Pan; Zi-sheng Lin; Jian-cong Wen; Jian-feng Guo; Xia-hui Wu; Ying-ying Liu; Wen-jun Lai; Qi-ying Liang; Yong-shi Xie; Yi-rou Chen; Yi-hong Chen; Ai-fen Yan; et al. (Biotechnology Letters, 2021)

Sodium P-aminosalicylic Acid Inhibits Manganese-Induced Neuroinflammation in BV2 Microglial Cells via NLRP3-CASP1 Inflammasome Pathway - Yuanyuan Fang; Dongjie Peng; Yuan Liang; Lili Lu; Junyan Li; Lin Zhao; Shiyan Ou; Shaojun Li; Michael Aschner; Yueming Jiang (Biological Trace Element Research, 2021)

Sphingobacterium rhinopitheci sp. Nov., isolated from the faeces of Rhinopithecus bieti in China - Xiu-Lin Han; Qiong Wang; Chen-Lu Zhang; Zhi-Qin Fang; Jian-Qiang Shen; Song Huang; Tao Lu (Archives of Microbiology, 2021)

Jatrophacine, a 4,5- seco -rhamnofolane diterpenoid with potent anti-inflammatory activity from Jatropha curcas - Yang Hu; Huimin Zhao; Aiping Yang; Qi Lv; Ning Ding; Tu-Lin Lu; Lihong Hu; Xiachang Wang (Natural Product Research, 2021)

Optimization of ultrasound and microwave-assisted extraction of sweet cherry tree branches and chemical component analysis by UPLC–MS/MS - Huimin Zhang; Hongguang Yan; Cuixiang Lu; Hui Lin; Quan Li (Trees, 2021)

Detection of Key Brown Rust Resistance Gene, Bru1, in 200 Sugarcane (Saccharum L.) Ancestral Species and Landraces Using a Four-Primer Molecular Marker - Xujuan Li; Chaohua Xu; Jun Mao; Hongbo Liu; Chunjia Li; Xinlong Liu; Xiuqin Lin; Chunyan Kong; Xin Lu (Sugar Tech, 2021)

Proteomics provides individualized options of precision medicine for patients with gastric cancer - Wenwen Huang; Dongdong Zhan; Yazhuo Li; Nairen Zheng; Xin Wei; Bin Bai; Kecheng Zhang; Mingwei Liu; Xuefei Zhao; Xiaotian Ni; Xia Xia; Jinwen Shi; et al. (Science China Life Sciences, 2021)

Role of the microRNA-29 family in myocardial fibrosis - Changyan Li; Nan Wang; Peng Rao; Limeiting Wang; Di Lu; Lin Sun (Journal of Physiology and Biochemistry, 2021)

Game strategies in government-led eco-compensation in the Xin’an River Basin from the perspective of the politics of scale - Yisheng Ren; Lin Lu; Hu Yu; Daocai Zhu (Journal of Geographical Sciences, 2021)

Porosity Prediction from Well Logs Using Back Propagation Neural Network Optimized by Genetic Algorithm in One Heterogeneous Oil Reservoirs of Ordos Basin, China - Lin Chen; Weibing Lin; Ping Chen; Shu Jiang; Lu Liu; Haiyan Hu (Journal of Earth Science, 2021)

Evaluation of the RNA extraction methods in different Ginkgo biloba L. tissues - Xiao-lin Zhang; Xiao-li Huang; Jia Li; Mei Mei; Wan-qi Zeng; Xiu-jun Lu (Biologia, 2021)

Geographic and subsequent biotic isolations led to a diversity anomaly of section Heterotropa (genus Asarum : Aristolochiaceae) in insular versus continental regions of the Sino‐Japanese Floristic Region - Daiki Takahashi; Shota Sakaguchi; Yu Feng; Yuji Isagi; Ying‐Xiong Qiu; Pan Li; Rui‐Sen Lu; Chang‐Tse Lu; Shih‐Wen Chung; Yang‐Shan Lin; Yun‐Chao Chen; Atsushi J. Nagano; et al. (Journal of Biogeography, 2021)
Aim The Sino‐Japanese Floristic Region has extremely high species diversity with respect to temperate plants; however, the reasons for this diversity are poorly understood because most studies have only considered geographic isolation caused by climatic oscillations. In some plant groups, high floral trait diversity and uneven species diversity between insular systems and the continental area suggest other factors may have important roles too. The primary purpose of this study is to reveal how abiotic and biotic factors have shaped the species diversity anomaly of Heterotropa between the insular systems and the continental area. Location The Sino‐Japanese Floristic Region. Taxon Section Heterotropa (genus Asarum ; Aristolochiaceae). Methods Using ddRAD‐seq and chloroplast genome data, we built a time‐calibrated phylogenetic tree including 79 species. We estimated the patterns of floral traits (flowering time and floral size) evolution using macroevolutionary modelling, and tested the correlation of speciation rate with the trait evolution rates. Finally, we estimated the isolation factors of all taxa pairs and sister‐taxa pairs based on distribution range and floral traits. Results Phylogenetic analysis indicated that Heterotropa was diverged into two clades (continental clade and insular clade) in the Miocene, and the major subclades corresponded to geographic entities. Most rate shifts accelerating floral trait's evolution occurred during the Pleistocene period. Evolution rate of floral traits showed positive correlation with the speciation rate. Large proportion of taxa in the insular clade are distributed allopatrically. Several sister pairs showed floral trait divergence with geographic overlap. Main Conclusions The diversification of Heterotropa appears to have been triggered by geographic and climatic events, and subsequent repeated floral trait evolution with and without geographic isolation. Furthermore, the high species diversity in the insular systems would have been formed by the repeated range fragmentations and contractions. Our study demonstrates the importance of multidimensional studies to understand the diversification process of temperate plants in the Sino‐Japanese Floristic Region.

Long‐term nitrogen input alters plant and soil bacterial, but not fungal beta diversity in a semiarid grassland - Weixing Liu; Lingli Liu; Xian Yang; Meifeng Deng; Zhou Wang; Pandeng Wang; Sen Yang; Ping Li; Ziyang Peng; Lu Yang; Lin Jiang (Global Change Biology, 2021)
Anthropogenic nitrogen (N) input is known to alter plant and microbial α‐diversity, but how N enrichment influences β‐diversity of plant and microbial communities remains poorly understood. Using a long‐term multilevel N addition experiment in a temperate steppe, we show that plant, soil bacterial and fungal communities exhibited different responses in their β‐diversity to N input. Plant β‐diversity decreased linearly as N addition increased, as a result of increased directional environmental filtering, where soil environmental properties largely explained variation in plant β‐diversity. Soil bacterial β‐diversity first increased then decreased with increasing N input, which was best explained by corresponding changes in soil environmental heterogeneity. Soil fungal β‐diversity, however, remained largely unchanged across the N gradient, with plant β‐diversity, soil environmental properties, and heterogeneity together explaining an insignificant fraction of variation in fungal β‐diversity, reflecting the importance of stochastic community assembly. Our study demonstrates the divergent effect of N enrichment on the assembly of plant, soil bacterial and fungal communities, emphasizing the need to examine closely associated fundamental components (i.e., plants and microorganisms) of ecosystems to gain a more complete understanding of ecological consequences of anthropogenic N enrichment.

Natural constituents from food sources as therapeutic agents for obesity and metabolic diseases targeting adipose tissue inflammation - Dan Li; Tian Zhang; Jinjian Lu; Cheng Peng; Ligen Lin (Critical Reviews in Food Science and Nutrition, 2021)

Plant-derived antioxidants incorporated into active packaging intended for vegetables and fatty animal products: a review - Yan Zhang; Baoying Wang; Fangfang Lu; Lin Wang; Yanhong Ding; Xinya Kang (Food Additives & Contaminants: Part A, 2021)

Quantification of SARS-CoV-2 antigen levels in the blood of patients with COVID-19 - Bin Su; Jiming Yin; Xingguang Lin; Tiantian Zhang; Xiao Yao; Ying Xu; Yao Lu; Wenzhi Wang; Kun Liu; Jie Zhang; Liangzhi Xie; Ronghua Jin; et al. (Science China Life Sciences, 2021)

Identification of a delayed leaf greening gene from a mutation of pummelo - Hui-Wen Yu; Zhi-Hao Lu; Xia Wang; Dan Liu; Jia-Xian He; Xiao-Lin Jiang; Ling-Jun Ke; Wen-Wu Guo; Xiu-Xin Deng; Qiang Xu (Science China Life Sciences, 2021)

Quantitative Fluorescence Resonance Energy Transfer Analysis on the Direct Interaction of Activation-2b with Histone H3/Switch-3B Protein in Arabidopsis Mesophyll Protoplasts - Lu Gao; Fangrui Lin; Danlu Han; Jieming Jiang; Chengwei Yang; Zhengfei Zhuang; Tongsheng Chen (Journal of Fluorescence, 2021)

Evaluation of the differences between biofilm and planktonic Brucella abortus via metabolomics and proteomics - Taishan Tang; Ye Xu; Jianfeng Wang; Xiao Tan; Xiaona Zhao; Ping Zhou; Fande Kong; Changqing Zhu; Chengping Lu; Huixing Lin (Functional & Integrative Genomics, 2021)

Phytoavailability, translocation and soil thresholds derivation of cadmium for food safety through soil-wheat (Triticum aestivum L.) system - Min Lu; Xuerui Cao; Qiang Lin; Bilal Hussain; Ying Feng; Zhenli He; Kyong Ju Kang; Xiaoe Yang (Environmental Science and Pollution Research, 2021)

Anti-Inflammatory Effects of an Extract from Pseudomonas aeruginosa and Its Purified Product 1-Hydroxyphenazine on RAW264.7 Cells - Jun Xiao; Aye Aye Thwe; Tingting Liu; Dafei Gong; Wanhua Lin; Changhua Shang; ZuJun Lu (Current Microbiology, 2021)

Activation of Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) with Lidocaine Provokes Pyroptosis of Glioblastoma Cells - B. Zhou; Y. Lin; S. Chen; J. Cai; Z. Luo; S. Yu; J. Lu (Bulletin of Experimental Biology and Medicine, 2021)

Nanoemulgel for Improved Topical Delivery of Desonide: Formulation Design and Characterization - Qiuyan Ma; Jing Zhang; Bohong Lu; Huaqing Lin; Rajib Sarkar; Tao Wu; Xuee Li (AAPS PharmSciTech, 2021)

Detection of Vestibular Schwannoma on Triple-parametric Magnetic Resonance Images Using Convolutional Neural Networks - Tzu-Hsuan Huang; Wei-Kai Lee; Chih-Chun Wu; Cheng-Chia Lee; Chia-Feng Lu; Huai-Che Yang; Chun-Yi Lin; Wen-Yuh Chung; Po-Shan Wang; Yen-Ling Chen; Hsiu-Mei Wu; Wan-You Guo; et al. (Journal of Medical and Biological Engineering, 2021)
Purpose The first step in typical treatment of vestibular schwannoma (VS) is to localize the tumor region, which is time-consuming and subjective because it relies on repeatedly reviewing different parametric magnetic resonance (MR) images. A reliable, automatic VS detection method can streamline the process. Methods A convolutional neural network architecture, namely YOLO-v2 with a residual network as a backbone, was used to detect VS tumors from MR images. To heighten performance, T1-weighted–contrast-enhanced, T2-weighted, and T1-weighted images were combined into triple-channel images for feature learning. The triple-channel images were cropped into three sizes to serve as input images of YOLO-v2. The VS detection effectiveness levels were evaluated for two backbone residual networks that downsampled the inputs by 16 and 32. Results The results demonstrated the VS detection capability of YOLO-v2 with a residual network as a backbone model. The average precision was 0.7953 for a model with 416 × 416-pixel input images and 16 instances of downsampling, when both the thresholds of confidence score and intersection-over-union were set to 0.5. In addition, under an appropriate threshold of confidence score, a high average precision, namely 0.8171, was attained by using a model with 448 × 448-pixel input images and 16 instances of downsampling. Conclusion We demonstrated successful VS tumor detection by using a YOLO-v2 with a residual network as a backbone model on resized triple-parametric MR images. The results indicated the influence of image size, downsampling strategy, and confidence score threshold on VS tumor detection.

p -Terphenyls and actinomycins from a Streptomyces sp. associated with the larva of mud dauber wasp - Dan-Dan Lu; Jin-Wei Ren; Qian-Qian Du; Ya-Jie Song; Shi-Qi Lin; Xia Li; Er-Wei Li; Wei-Dong Xie (Natural Product Research, 2021)

A survey of chloramphenicol residues in aquatic products of Shenzhen, South China - Lan Luo; Shaoyou Lu; Chengpeng Huang; Fu Wang; Yan Ren; He Cao; Qihui Lin; Zhiqiang Tan; Xiaodong Wen (Food Additives & Contaminants: Part A, 2021)

Different posterior hippocampus and default mode network modulation in young APOE ε4 carriers: a functional connectome-informed phenotype longitudinal study - Li Juan Zheng; Li Lin; U. Joseph Schoepf; Akos Varga-Szemes; Rock H. Savage; Han Zhang; Yun Fei Wang; Xin Yuan Zhang; Song Luo; Ya Liu; Gui Fen Yang; Guang Ming Lu; et al. (Molecular Neurobiology, 2021)

Blocking the JAK2/STAT3 and ERK pathways suppresses the proliferation of gastrointestinal cancers by inducing apoptosis - Xi Wang; Chunyan Dai; Yifei Yin; Lin Wu; Weiyang Jin; Yufei Fu; Zhe Chen; Ke Hao; Bin Lu (Journal of Zhejiang University-SCIENCE B, 2021)

Effects of multi-phase inoculation on the fungal community related with the improvement of medicinal herbal residues composting - Xiao-Lin Lu; Hao Wu; Shi-Li Song; Hong-Yan Bai; Meng-Jun Tang; Fang-Ji Xu; Yan Ma; Chuan-Chao Dai; Yong Jia (Environmental Science and Pollution Research, 2021)

BRCA1: a key player at multiple stages of homologous recombination in DNA double-strand break repair - Yidan Liu; Lin-Yu Lu (Genome Instability & Disease, 2021)

Ring distribution patterns—diversification or speciation? Comparative phylogeography of two small mammals in the mountains surrounding the Sichuan Basin - Yanqun Wang; Anderson Feijó; Jilong Cheng; Lin Xia; Zhixin Wen; Deyan Ge; Jian Sun; Liang Lu; Song Li; Qisen Yang (Molecular Ecology, 2021)
Studying the genetic differentiation in a unique geographical area contributes to understanding the process of speciation. Here, we explore the spatial genetic structure and underlying formation mechanism of two congeneric small mammal species ( Apodemus draco and A. chevrieri ), which are mainly distributed in the mountains surrounding the lowland Sichuan Basin, southwest China. We applied a set of comparative phylogeographical analyses to determine their genetic diversification patterns, combining mitochondrial ( Cytb and COI ) and nuclear (microsatellite loci) markers, with dense sampling throughout the range (411 A . draco from 21 sites and 191 A . chevrieri from 22 sites). Moreover, we performed three complementary statistical methods to investigate the correlation between genotype and geographical and environmental components, and predicted the potential suitable distributional range under the present and historical climate conditions. Our results suggest that both species have experienced allopatric differentiation and admixture in historical periods, resulting in a ring‐shape diversification, under the barrier effect of the Sichuan Basin. We infer that the tectonic events of the Qinghai–Tibetan Plateau and climatic oscillations during the Quaternary played an important role on the genetic divergence of the two species by providing environmental heterogeneity and geographical variation. Our study reveals a case of two sympatric small mammals following a ring‐shaped diversification pattern and provides insight into the process of differentiation.

PtP38 May Increase the Immune Ability of Portunus trituberculatus Stimulated by LPS Imitating a Gram-Negative Bacterial Infection - Cheng-Peng Lu; Chao-Guang Wei; Jun-Quan Zhu; Dao-Jun Tang; Chun-Lin Wang; Cong-Cong Hou (Frontiers in Marine Science, 2021)
The P38 mitogen-activated protein kinase (MAPK) signal transduction pathway is widespread in organisms and plays important roles in immune activities. The infection mechanism of environmental gram-negative bacteria on crustaceans is an important scientific problem. In this study, the cDNA full-length sequence of Portunus trituberculatus P38 (PtP38) was cloned and its structure was analyzed by bioinformatics methods. To study the function of the PtP38 gene after a Gram-negative bacterial infection, we injected P. trituberculatus with LPS to activate the immune response instead of directly infecting with Gram-negative bacteria. With LPS stimulation, the expression of the PtP38 gene in different tissues increased significantly. At the same time, the expression of immune-related genes (ALF and crustin) in the hepatopancreas, activities of antioxidant enzymes [superoxide dismutase (SOD), catalase (CAT), and inducible nitric oxide synthase (iNOS) enzymes], and expression of apoptosis-related genes (caspase2 and caspase3) were increased significantly. To further conform the function of PtP38 in the immune response, we injected P. trituberculatus with P38 inhibitor and subsequently injected with LPS. The results showed that the expression of immune-related genes was inhibited, the activity of antioxidant enzymes was decreased, and the expression of apoptosis-related genes were inhibited. Thus, we speculated that PtP38 may increase the immune ability by improving the expression of antimicrobial peptides, increasing the activity of oxidative stress-related enzymes, and promoting cell apoptosis in infected P. trituberculatus . This study also laid the foundation for further study of the P38 MAPK signaling pathway and immune mechanism of P. trituberculatus .

Study on Microwave Heating Order and Electromagnetic Characteristics of Copper and Gold Ores - Feng Lin; Xia-Ting Feng; Gao-Ming Lu; Xiang-Xin Su; Shi-Ping Li; Jiu-yu Zhang (Rock Mechanics and Rock Engineering, 2021)

Identification of two UDP-glycosyltransferases involved in the main oleanane-type ginsenosides in Panax japonicus var. major - Jun-Rong Tang; Geng Chen; Ying-Chun Lu; Qing-Yan Tang; Wan-Ling Song; Yuan Lin; Ying Li; Su-Fang Peng; Sheng-Chao Yang; Guang-Hui Zhang; Bing Hao (Planta, 2021)

Targeted deletion of HAI-1 increases prostasin proteolysis but decreases matriptase proteolysis in human keratinocytes - Dajun D. Lu; Yayun Gu; Sheng-Wen A. Li; Robert J. Barndt; Shih-Ming Huang; Jehng-Kang Wang; Hui Chen Su; Michael D. Johnson; Chen-Yong Lin (Human Cell, 2021)

Impact factors of the accumulation, migration and spread of antibiotic resistance in the environment - Zibo Lin; Tao Yuan; Lai Zhou; Sen Cheng; Xu Qu; Ping Lu; Qiyan Feng (Environmental Geochemistry and Health, 2021)

Construction of an infectious full-length cDNA clone of potato aucuba mosaic virus - Buyang Chen; Qi Lin; Yueyan Yin; Liangliang Jiang; Fang Wang; Shuzhen Hu; Xinyang Wu; Fei Xu; Jiejun Peng; Hongying Zheng; Chengqi Yan; Xiaohan Mo; et al. (Archives of Virology, 2021)

Effects of Climate Change in Marine Ecosystems Based on the Spatiotemporal Age Structure of Top Predators: A Case Study of Bigeye Tuna in the Pacific Ocean - Kuo-Wei Lan; Yan-Lun Wu; Lu-Chi Chen; Muhamad Naimullah; Tzu-Hsiang Lin (Frontiers in Marine Science, 2021)
How top predators behave and are distributed depend on the conditions in their marine ecosystem through bottom−up forcing; this is because where and when these predators can feed and spawn are limited and change often. This study investigated how the catch rates of immature and mature cohorts of bigeye tuna (BET) varied across space and time; this was achieved by analyzing data on the Taiwanese longline fishery in the western and central Pacific Ocean (WCPO). We also conducted a case study on the time series patterns of BET cohorts to explore the processes that underlie the bottom-up control of the pelagic ecosystem that are influenced by decadal climate events. Wavelet analysis results revealed crucial synchronous shifts in the connection between the pelagic ecosystems at low trophic levels in relation to the immature BET cohort. Many variables exhibited decreasing trends after 2004–2005, and we followed the Pacific Decadal Oscillation (PDO) as a bottom-up control regulator. The results indicated that low recruitment into the mature cohort occurs 3 years after a decrease in the immature cohort’s food stocks, as indicated by a 3-year lag in our results. This finding demonstrated that, by exploring the connection between low-trophic-level species and top predators at various life stages, we can better understand how climate change affects the distribution and abundance of predator fish.

Selective Ferroptosis Inhibitor Liproxstatin-1 Attenuates Neurological Deficits and Neuroinflammation After Subarachnoid Hemorrhage - Yang Cao; Yin Li; Chao He; Feng Yan; Jian-Ru Li; Hang-Zhe Xu; Jian-Feng Zhuang; Hang Zhou; Yu-Cong Peng; Xiong-Jie Fu; Xiao-Yang Lu; Yuan Yao; et al. (Neuroscience Bulletin, 2021)

Exendin-4 Reversed the PC12 Cell Damage Induced by circRNA CDR1as/miR-671/GSK3β Signaling Pathway - Hui Quan; Qiudan Chen; Kesheng Wang; Qinwan Wang; Meiling Lu; Yue Zhang; Sujing Qiang; Shaobo Xue; Lin Han; Huanhuan Zhu; Qiangyuan Fan; Meiyu Bao; et al. (Journal of Molecular Neuroscience, 2021)

EEG-Based Anxious States Classification Using Affective BCI-Based Closed Neurofeedback System - Chao Chen; Xuecong Yu; Abdelkader Nasreddine Belkacem; Lin Lu; Penghai Li; Zufeng Zhang; Xiaotian Wang; Wenjun Tan; Qiang Gao; Duk Shin; Changming Wang; Sha Sha; et al. (Journal of Medical and Biological Engineering, 2021)

Glycogen synthase kinase-3β (GSK-3β) deficiency inactivates the NLRP3 inflammasome-mediated cell pyroptosis in LPS-treated periodontal ligament cells (PDLCs) - Xiaolu Zhang; Shan He; Wanyu Lu; Lijia Lin; Hui Xiao (In Vitro Cellular & Developmental Biology - Animal, 2021)

Identification and characterization of CONSTANS-like genes from Curcuma alismatifolia - Yuan-Yuan Li; Xiao-Huang Chen; Hui-Wen Yu; Qi-Lin Tian; Luan-Mei Lu (Horticulture, Environment, and Biotechnology, 2021)

Chinese construction industry energy efficiency analysis with undesirable carbon emissions and construction waste outputs - Xuedong Liang; Shifeng Lin; Xueyao Bi; Enfan Lu; Zhi Li (Environmental Science and Pollution Research, 2021)

Comparative understanding of metal hyperaccumulation in plants: a mini-review - Jia-Shi Peng; Yu-Hao Guan; Xian-Jing Lin; Xiao-Jing Xu; Lu Xiao; Hai-Hua Wang; Shuan Meng (Environmental Geochemistry and Health, 2021)

Catalyst-free visible-light induced synthesis of nitrogen- and oxygen-containing heterocycles from 1,3-diketones - Lu Chen; Zhenyuan lin; Xuefang Zhang; Leshi Tan; Min Zhang; Yibiao Li (Environmental Chemistry Letters, 2021)

The molecular mechanism of a novel derivative of BTO-956 induced apoptosis in human myelomonocytic lymphoma cells - Yu-Lin Li; De-Jun Zhou; Zheng-Guo Cui; Lu Sun; Qian-Wen Feng; Shahbaz Ahmad Zakki; Yusuke Hiraku; Cheng-Ai Wu; Hidekuni Inadera (Apoptosis, 2021)

Western North Pacific Tropical Cyclone Database Created by the China Meteorological Administration - Xiaoqin Lu; Hui Yu; Ming Ying; Bingke Zhao; Shuai Zhang; Limin Lin; Lina Bai; Rijin Wan (Advances in Atmospheric Sciences, 2021)
This paper describes the access to, and the content, characteristics, and potential applications of the tropical cyclone (TC) database that is maintained and actively developed by the China Meteorological Administration, with the aim of facilitating its use in scientific research and operational services. This database records data relating to all TCs that have passed through the western North Pacific (WNP) and South China Sea (SCS) since 1949. TC data collection has expanded over recent decades via continuous TC monitoring using remote sensing and specialized field detection techniques, allowing collation of a multi-source TC database for the WNP and SCS that covers a long period, with wide coverage and many observational elements. This database now comprises a wide variety of information related to TCs, such as historical or real-time locations (i.e., best track and landfall), intensity, dynamic and thermal structures, wind strengths, precipitation amounts, and frequency. This database will support ongoing research into the processes and patterns associated with TC climatic activity and TC forecasting.

Preparation of High-Drug-Loaded Clarithromycin Gastric-Floating Sustained-Release Tablets Using 3D Printing - Peihong Chen; Haosen Luo; Siyu Huang; Jinling Liu; Minmei Lin; Fan Yang; Junfeng Ban; Zeju Huang; Zhufen Lu; Qingchun Xie; YanZhong Chen (AAPS PharmSciTech, 2021)

New secondary metabolite with cytotoxicity from spawning soft coral Asterospicularia laurae in Taiwan - Jui-Hsin Su; Chih-I Liu; Mei-Chin Lu; Chi-I Chang; Min-Ying Hsieh; Yu-Chi Lin; Chang-Feng Dai; Ya-Han Zhang; Zheng-Yu Lin; Yun-Sheng Lin (Natural Product Research, 2021)

Applications of Nanoparticle-Antibody Conjugates in Immunoassays and Tumor Imaging - Xinhao Lin; André O’Reilly Beringhs; Xiuling Lu (The AAPS Journal, 2021)
Modern diagnostic technologies rely on both in vitro and in vivo modalities to provide a complete understanding of the clinical state of a patient. Nanoparticle-antibody conjugates have emerged as promising systems to confer increased sensitivity and accuracy for in vitro diagnostics (e.g., immunoassays). Meanwhile, in vivo applications have benefited from the targeting ability of nanoparticle-antibody conjugates, as well as payload flexibility and tailored biodistribution. This review provides an encompassing overview of nanoparticle-antibody conjugates, from chemistry to applications in medical immunoassays and tumor imaging, highlighting the underlying principles and unique features of relevant preclinical applications employing commonly used imaging modalities (e.g., optical/photoacoustics, positron-emission tomography, magnetic resonance imaging, X-ray computed tomography).

Megafaunal Community Structure From the Abyssal to Hadal Zone in the Yap Trench - Dongsheng Zhang; Yadong Zhou; Jichao Yang; Thomas Linley; Ruiyan Zhang; Bo Lu; Peng Xu; Chengcheng Shen; Shiquan Lin; Yueyun Wang; Dong Sun; Xiaogu Wang; et al. (Frontiers in Marine Science, 2021)
Hadal trenches remain one of the unexplored ocean ecosystems due to the challenges of sampling at great depths. It is still unclear how a faunal community changes from the abyssal to the hadal zone, and which environmental variables are the key impacting factors. In this study, nine dives of the Human Occupied Vehicle (HOV) “ JIAOLONG ” were conducted from abyssal to hadal depths (4,435–6,796 m) in the Yap Trench on the southeastern boundary of the Philippine Sea Plate in the western Pacific, divided into 48,200 m video transects, to describe the megafaunal communities and reveal their relationship with environmental factors. A total of 1,171 megafauna organisms was recorded, 80 morphospecies (msps) from 8 phyla were identified based on the video data, most of which were reported for the first time in the Yap Trench. Arthropoda was the most abundant phylum and Echinodermata was the most diverse phylum of the megafaunal community. The faunal abundance increased with depth, whereas the Shannon diversity index decreased with depth. Cluster analysis suggested seven assemblages, with five abyssal groups, one mixed group, and one hadal dominant group. Although megafaunal communities changed gradually from abyssal zone to hadal zone, both PERMANOVA and PERMDISP analyses revealed that the communities are significantly different between abyssal zone and hadal zone, indicating 6,000 m as the boundary between the two depth zones. Depth, substrate, slope, and latitude were identified as four important environmental factors with significant influence on megafaunal community structure. This study proposed a transition pattern from the abyssal to hadal zone in the Yap Trench, highlighted the importance of habitat heterogeneity in structuring megafaunal community in a hadal trench.

Surrogate-Based Stochastic Multiobjective Optimization for Coastal Aquifer Management under Parameter Uncertainty - Zheng Han; Wenxi Lu; Yue Fan; Jianan Xu; Jin Lin (Water Resources Management, 2021)

Analytical Stress Solutions for a Deep Buried Circular Tunnel Under an Unsteady Temperature Field - Qian-xiang Cheng; Ai-zhong Lu; Chong-lin Yin (Rock Mechanics and Rock Engineering, 2021)

At3g53630 encodes a GUN1-interacting protein under norflurazon treatment - Xing-Qi Huang; Lin-Juan Wang; Meng-Juan Kong; Na Huang; Xin-Ya Liu; Han-Yu Liang; Jia-Xin Zhang; Shan Lu (Protoplasma, 2021)

PCA-RF model for Dendrolimus punctatus Walker damage detection - Zhanghua Xu; Wenchun Shi; Lu Lin; Xuying Huang; Yue Wang; Jian Liu; Kunyong Yu (Natural Hazards, 2021)

The response to flooding of two overwintering rice stem borers likely accounts for their changing impacts - Guang-Hua Luo; Zhi-Xin Luo; Zhi-Ling Zhang; Yang Sun; Ming-Hong Lu; Zhao-Lin Shu; Zi-Hua Tian; Ary A. Hoffmann; Ji-Chao Fang (Journal of Pest Science, 2021)

Sexual communication in diurnal moths: behaviors and mechanisms - Lian Chen; Xiao-Yun Wang; Wen Lu; Xia-Lin Zheng (International Journal of Tropical Insect Science, 2021)

MiR-501-3p promotes osteosarcoma cell proliferation, migration and invasion by targeting BCL7A - Jinliang Dai; Lin Lu; Lixin Kang; Jian Zhang (Human Cell, 2021)

Remediation of contaminated soil and groundwater using chemical reduction and solidification/stabilization method: a case study - Shi-Feng Lu; Yu-Lin Wu; Zhan Chen; Tao Li; Chao Shen; Lin-Kang Xuan; Ling Xu (Environmental Science and Pollution Research, 2021)

Prediction models of pulp components based on the quality indices in bleaching process - Zhichao Ma; Shaoxu Chen; Yongjun Yin; Xiaodan Lu; Yanying Zhou; Tingting Lin (Environment, Development and Sustainability, 2021)

Description of the reservoir along strike-slip fault zones in China T-Sh oilfield, Tarim Basin - Rui Zhao; Shang Deng; Lu Yun; Huixi Lin; Teng Zhao; Chen Yu; Qiangfu Kong; Qiang Wang; Huili Li (Carbonates and Evaporites, 2021)

Complete genome sequence of a novel foveavirus isolated from Allium sativum L. in China - Qi Luo; Shuzhen Hu; Qi Lin; Fei Xu; Jiejun Peng; Hongying Zheng; Guanwei Wu; Shaofei Rao; Jianping Chen; Yuwen Lu; Fengling Guo; Fei Yan (Archives of Virology, 2021)

Lentibacillus saliphilus. sp. nov., a moderately halophilic bacterium isolated from a saltern in Korea - Yun Wang; Gang-Qiang Jiang; Hong-Ping Lin; Peng Sun; Hong-Yan Zhang; Dong-Mei Lu; Li-Yun Wang; Chang-Jin Kim; Shu-Kun Tang (Archives of Microbiology, 2021)

Disinfection efficiency of hospital infectious disease wards with chlorine dioxide and hypochlorous acid - Ming-Chun Lu; Po-Lin Chen; Da-Ji Huang; Chih-Kuo Liang; Ching-Shan Hsu; Wei-Ting Liu (Aerobiologia, 2021)