Ergosterol peroxide: an effect-directed detecting method from Anoectochilus elwesii and evaluation of anticancer activity - Yanduan Lin; Bingqin Wen; Ziwei Zhang; Jinyan Cai (Natural Product Research, 2022)

Recent developments in vibrational spectral analyses for dynamically assessing and monitoring food dehydration processes - Yuqiao Ren; Xiaohui Lin; Tong Lei; Da-Wen Sun (Critical Reviews in Food Science and Nutrition, 2022)

Vegetation dynamics and their response to Holocene climate change derived from multi-proxy records from Wangdongyang peat bog in southeast China - Lin Zhao; Chunmei Ma; Zhenming Wen; Wei Ye; Guangchun Shang; Lingyu Tang (Vegetation History and Archaeobotany, 2022)

Transcriptome Changes Induced by Botrytis cinerea Stress and Weighted Gene Co-expression Network Analysis (WGCNA) in Actinidia chinensis - Zhe-Xin Li; Wen-Lin Zhang; Deng-Wei Jue; Xia Liu; Yu-Song Jiang; Jian-Min Tang (Plant Molecular Biology Reporter, 2022)

Activation of Neuropeptide Y2 Receptor Can Inhibit Global Cerebral Ischemia-Induced Brain Injury - Reggie Hui-Chao Lee; Celeste Yin-Chieh Wu; Cristiane T. Citadin; Alexandre Couto e Silva; Harlee E. Possoit; Garrett A. Clemons; Christina H. Acosta; Victoria A. de la Llama; Jake T. Neumann; Hung Wen Lin (NeuroMolecular Medicine, 2022)

Bedside Diagnosis for Disseminated Deep Dermatophytosis: a Case Series Study - Xiu-Jiao Xia; Hong Shen; Hui-Lin Zhi; Yan Zhong; Bo Sang; Wen-Wen Lv; Qiu-Ping Li; Ze-Hu Liu (Mycopathologia, 2022)

Association between MAP3K4 gene polymorphisms and the risk of schizophrenia susceptibility in a Northeast Chinese Han population - Yang Sun; Ye Lv; Hui-Wen Ren; Guan-Yu Wang; Li-Na Xuan; Yi-Yang Luo; Zhi-Lin Luan (Metabolic Brain Disease, 2022)

Comprehensive Transcriptome Analysis of Gonadal and Somatic Tissues for Identification of Sex-Related Genes in the Largemouth Bass Micropterus salmoides - Wen-Zhi Guan; Kai Jiang; Xing-Lin Lai; Yao-Ting Dong; Gao-Feng Qiu (Marine Biotechnology, 2022)

Should Plate-Bone Gap be Preserved in Far-Cortical Locking Technique? A Biomechanical Study - Shun-Ping Wang; Yang-Chen Chou; Cheng-En Hsu; Chi-Wen Chou; Chao-Ping Chen; Kun-Jhih Lin; Fuu-Cheng Jiang; Wen-Chuan Chen; Chen-Chiang Lin (Journal of Medical and Biological Engineering, 2022)

Elevated α-synuclein and NfL levels in tear fluids and decreased retinal microvascular densities in patients with Parkinson’s disease - Chao-Wen Lin; Tzu-Ting Lai; Szu-Ju Chen; Chin-Hsien Lin (GeroScience, 2022)

Long-term exercise pre-training attenuates Alzheimer’s disease–related pathology in a transgenic rat model of Alzheimer’s disease - Luodan Yang; Chongyun Wu; Yong Li; Yan Dong; Celeste Yin-Chieh Wu; Reggie Hui-Chao Lee; Darrell W. Brann; Hung Wen Lin; Quanguang Zhang (GeroScience, 2022)

Bisphosphonate of Zoledronate Has Antiapoptotic Effect on Hypoxia/Reoxygenation Injury in Human Embryonic Stem Cell-Derived Cardiomyocytes Through Trk Signaling Pathway - Hua Wang; Wen-Shu Zhao; Lin Xu (Cell Biochemistry and Biophysics, 2022)

The behavior of REEs indicates the dolomite petrogenesis and a unique dolomitization model of the Middle Permian Qixia formation in Northwest Sichuan Basin, China - Shengyang Xie; Xingzhi Wang; Bo Li; Long Wen; Liang Xu; Yao Du; Lin Xie; Yong Li; Yaping Wang; Yawen Li (Carbonates and Evaporites, 2022)

Investigation on long-term progressive deformation of engineering slope based on comprehensive monitoring - Shi-shu Zhang; Song-feng Guo; Sheng-wen Qi; Feng-jiao Tang; Jin-shan Hu; Xiao-ping Zhao; Cong-yan Ran; Xin Wang; Yu Zou; Xiao-lin Huang; Bo-wen Zheng; Ning Liang (Journal of Mountain Science, 2022)

Flow-slide characteristics and failure mechanism of shallow landslides in granite residual soil under heavy rainfall - Hui-lin Bai; Wen-kai Feng; Shuang-quan Li; Long-zhen Ye; Zhong-teng Wu; Rui Hu; Hong-chuan Dai; Yun-peng Hu; Xiao-yu Yi; Peng-cheng Deng (Journal of Mountain Science, 2022)

Comparison of different inversion methods of D-T2 two-dimensional nuclear magnetic resonance logging and applicability analysis - Cheng-Lin Li; Mao-Jin Tan; Ke-Wen Wang; Feng Zhou; Ying-Ming Liu; Hai-Tao Zhang; Li-Zhi Xiao (Applied Geophysics, 2022)

Microcosmic Characteristics of Hydrate Formation and Decomposition in the Different Particle Size Sediments Captured by Cryo-SEM - Jingsheng Lu; Decai Lin; Dongliang Li; Deqing Liang; Long Wen; Siting Wu; Yiqun Zhang; Yong He; Lingli Shi; Youming Xiong (Journal of Marine Science and Engineering, 2022)
Sand production and sand control studies in non-diagenetic reservoirs are the weak point in the conventional petroleum industry. However, natural gas hydrate (NGH) mainly exists in non-diagenetic strata, and sand production occurs during exploitation, which restricts the safe and sustainable production of NGH. To study the microcosmic characteristics of sand production, the hydrate decomposition behaviours in the sediments were captured by the Cryo-SEM method. The micromorphology of different particle sizes of sand samples containing NGH (the sand median diameter d50 is 150, 87, 55, 38, 24, and 13 µm) and the microcosmic processes of NGH decomposition were observed. Then, the microcosmic characteristics of sand production, during the decomposition process, were analysed. (1) The gas hydrate decomposition increases pore space and reduces reservoir strength; the expansion action of the decomposition of water and gas, the softening action of the decomposition of water, and the compression action by overlying stress (crustal stress) promoted sand production, deformation, and subsidence of the NGH reservoirs in the mining process. (2) The decomposition of NGH has a more significant impact on sediments with smaller particle sizes. (3) The particle size of NGH may be larger than the particle size of the mud in the reservoirs, and acting as “gravel” plays a particular role in sand control. Therefore, the particle size of NGH cannot be ignored in the design of sand control. (4) It has been revealed, and verified, that sputtering (splashing) is a unique process of sand production caused by NGH decomposition. In other words, the rapid expansion of the volume of the decomposed gas and water from NGH leads to the eruption and sputtering of hydrate particles, providing the driving force for sand migration, which is a different process of sand production than in conventional oil and gas.

Optimization of aquaculture sustainability through ecological intensification in China - Shuang‐lin Dong; Yun‐wei Dong; Ling Cao; Johan Verreth; Yngvar Olsen; Wen‐jing Liu; Qi‐zhi Fang; Yan‐gen Zhou; Li Li; Jing‐yu Li; Yong‐tong Mu; Patrick Sorgeloos (Reviews in Aquaculture, 2022)
As the world's leading producer of farmed aquatic food products, China faces great uncertainty concerning the further sustainable development of its aquaculture industry due to high and increasing pressure from environmental and resource constraints. To realize truly sustainable development, it is imperative to establish an evaluation system that integrates social, economic, environmental and resource criteria, and optimizes aquaculture systems through a holistic approach. Here, we used analytical hierarchy processes combined with expert judgment and objective data to assess the sustainability of 10 major aquaculture production systems (APSs) in China. Based on the evaluation results, we propose the ecological intensification of aquaculture systems (ELIAS), rationally integrating anthropogenic inputs with aquaculture ecosystem services, to improve the sustainability of APSs. The holistic evaluation system and ELIAS are fundamental and critical for the future development of aquaculture in China and globally.

Cover Image, Volume 14, Issue 3 - Shuang‐lin Dong; Yun‐wei Dong; Ling Cao; Johan Verreth; Yngvar Olsen; Wen‐jing Liu; Qi‐zhi Fang; Yan‐gen Zhou; Li Li; Jing‐yu Li; Yong‐tong Mu; Patrick Sorgeloos (Reviews in Aquaculture, 2022)
The cover image is based on the Review Article Optimization of aquaculture sustainability through ecological intensification in China by Shuang‐lin Dong et al., https://doi.org/10.1111/raq.12648 image

Risk Assessment of Navigation Safety for Ferries - Wen-Kai K. Hsu; Jun-Wen Chen; Nguyen Tan Huynh; Yan-You Lin (Journal of Marine Science and Engineering, 2022)
This study aims to discuss a risk assessment of navigation safety for ferries. In this research, the risk factors (RFs) for the navigation safety of ferries are first investigated from relevant literature and ferry operational features. A fuzzy AHP (Analytic Hierarchical Process) approach is then proposed to weight those RFs, after which a continuous risk-matrix model is then developed to determine the RFs’ risk levels. Finally, to validate the practical application of the proposed model, ferries traveling across the Taiwan Strait were empirically investigated. The results may provide practical information for ferry operators to improve their safety performances. Further, the proposed risk assessment approach may provide references for related research in the safety management of short-distance passenger ships.

The Fishery Value Chain Analysis in Taiwan - Tsung-Yu Yang; Hsing-Chun Lin; Wen-Hong Liu (Fishes, 2022)
Although the GDP of the fishery sector accounts for less than 0.3% of Taiwan’s GDP, there are many secondary and tertiary industries related to fisheries that add great value to the country’s economy. Therefore, when analyzing and calculating the output value and value added of the fishery sector, the relevance of these upstream and downstream industries should be considered jointly, and the value chain of the fishery industry should be studied and analyzed in order to truly present the value added created by fishery. This study aims to do this by first analyzing not only the primary fishery industry, but the value chain of the fishery industry at different stages such as fishery production, marine fishing, aquaculture, fishery processing, retail and services, and supportive systems. Then the value added of the whole fishery value chain to Taiwan’s GDP is estimated by using the Leontief input–output model, from the perspective of industry linkages and covering the period from 2011 to 2018. The empirical results suggest that the value added created by fishery and related industries accounted for 2.96% of the GDP in 2011, which rose to 3.11% in 2014, fell to 2.87% in 2015, rose to 2.93% in 2017, and fell to 2.84% in 2018. From 2011 to 2018, the amount of value added created by fisheries and related industries rose from NT$ 422.8 billion to NT$ 520.9 billion. The primary fishery sector has the largest contribution, followed by the fishery input sector, and transportation and sale service sector, and the fishery product processing sector has the lowest contribution rate. The empirical results provide important implications and references to the policy makers.

Effects of Involuntary and Voluntary Exercise in Combination with Acousto-Optic Stimulation on Adult Neurogenesis in an Alzheimer's Mouse Model - Wan-yi Li; Jun-yan Gao; Su-Yang Lin; Shao-tao Pan; Biao Xiao; Yu-tao Ma; Kai Xie; Wei Shen; Zhi-tao Liu; Guang-yu Li; Jie-jie Guo; Qin-wen Wang; et al. (Molecular Neurobiology, 2022)

Exercise Rehabilitation and/or Astragaloside Attenuate Amyloid-beta Pathology by Reversing BDNF/TrkB Signaling Deficits and Mitochondrial Dysfunction - Yu-Lin Wang; Chung-Ching Chio; Shu-Chun Kuo; Chao-Hung Yeh; Jui-Ti Ma; Wen-Pin Liu; Mao-Tsun Lin; Kao-Chang Lin; Ching-Ping Chang (Molecular Neurobiology, 2022)

Identification of PDXDC1 as a novel pleiotropic susceptibility locus shared between lumbar spine bone mineral density and birth weight - Yu-Qian Song; Shi-Di Hu; Xu Lin; Xiang-He Meng; Xiao Wang; Yin-Hua Zhang; Cheng Peng; Rui Gong; Tao Xu; Tong Zhang; Chen-Zhong Li; Dao-Yan Pan; et al. (Journal of Molecular Medicine, 2022)
An increasing number of epidemiological studies have suggested that birth weight (BW) may be a determinant of bone health later in life, although the underlying genetic mechanism remains unclear. Here, we applied a pleiotropic conditional false discovery rate (cFDR) approach to the genome-wide association study (GWAS) summary statistics for lumbar spine bone mineral density (LS BMD) and BW, aiming to identify novel susceptibility variants shared between these two traits. We detected 5 novel potential pleiotropic loci which are located at or near 7 different genes ( NTAN1 , PDXDC1 , CACNA1G , JAG1 , FAT1P1 , CCDC170 , ESR1 ), among which PDXDC1 and FAT1P1 have not previously been linked to these phenotypes. To partially validate the findings, we demonstrated that the expression of PDXDC1 was dramatically reduced in ovariectomized (OVX) mice in comparison with sham-operated (SHAM) mice in both the growth plate and trabecula bone. Furthermore, immunohistochemistry assay with serial sections showed that both osteoclasts and osteoblasts express PDXDC1 , supporting its potential role in bone metabolism. In conclusion, our study provides insights into some shared genetic mechanisms for BMD and BW as well as a novel potential therapeutic target for the prevention of OP in the early stages of the disease development. Key messages We investigated pleiotropy-informed enrichment between LS BMD and BW. We identified genetic variants related to both LS BMD and BW by utilizing a cFDR approach. PDXDC1 is a novel pleiotropic gene which may be related to both LS BMD and BW. Elevated expression of PDXDC1 is related to higher BMD and lower ratio n-6/n-3 PUFA indicating a bone protective effect of PDXDC1.

Mixed effects of perfluoroalkyl and polyfluoroalkyl substances exposure on cognitive function among people over 60 years old from NHANES - Xueqiong Weng; Huanzhu Liang; Yuxuan Tan; Jingmin Chen; Qiaoyuan Fei; Shan Liu; Xinrong Guo; Lin Wen; Yingying Wu; Chunxia Jing (Environmental Science and Pollution Research, 2022)

Study on water resources carrying capacity in Zhuanglang River Basin - Wen Xu; Chang Zhou; Bingrui Liu; Dongxue Wang; Xingzhu Zhao; Xiaojing Yang; Xiaotao Zhu; Zimu Lin (Environmental Monitoring and Assessment, 2022)
With the rapid development of China’s social economy, the phenomenon of unbalanced regional economic development is increasingly obvious. The shortage of water resources in northwest China is an important constraint to local development. The study on the water resources carrying capacity of the Zhuanglang River Basin plays an important role in the development of local economy; thus, we evaluate the water resources situation of Zhuanglang River Basin by using hydrology-related calculation method, combining with field investigation, visiting relevant departments, and referring to relevant data. Meanwhile, the water resources carrying capacity of 3 counties and 12 townships in the Zhuanglang River Basin in the current year are studied and analyzed based on methods such as fuzzy comprehensive evaluation model and quantitative calculation. Results indicate that the carrying capacity of water resources in Zhuanglang river basin can mostly meet the needs of township, but it is necessary to further optimize the water resources carrying capacity of the Zhuanglang River Basin from the four systems of water resources, society, economy, and ecology in the future. Besides, the results of quantitative calculation show that the maximum economic scale that water resources can withstand in most areas of the Zhuanglang River Basin is the overall well-off level, that is, the per capita domestic water is 80L/(d· person), and the per capita GDP is 10000 yuan/person. But there is still a certain gap to achieve the level, when the people are well-off in an all-round way, the two indexes are correspondently raised to 120L/(d· person), and the per capita GDP is 30,000 yuan/person.

Probabilistic stability analysis of embankment slopes considering the spatial variability of soil properties and seismic randomness - Wen-gang Zhang; Jia-hao Wu; Xin Gu; Liang Han; Lin Wang (Journal of Mountain Science, 2022)

TRIP13 knockdown inhibits the proliferation, migration, invasion, and promotes apoptosis by suppressing PI3K/AKT signaling pathway in U2OS cells - De-Chen Yu; Xiang-Yi Chen; Hai-Yu Zhou; De-Quan Yu; Xiao-Lei Yu; Yi-Cun Hu; Rui-Hao Zhang; Xiao-Bo Zhang; Kun Zhang; Mao-Qiang Lin; Xi-Dan Gao; Tao-Wen Guo (Molecular Biology Reports, 2022)

Heat Shock Procedure Affects Cell Division-Associated Genes in Gynogenetic Manipulation - Fan Yu; Jian-Lin Li; Wen-Rong Feng; Yong-Kai Tang; Sheng-Yan Su; Pao Xu; Huan Zhong (Marine Biotechnology, 2022)

Biomechanical superiority of locking plate designed with cluster of head screws compared to conventional buttress plate for fixation of posteromedial tibial plateau fractures: A computational assessment - Kai-Cheng Lin; Yih-Wen Tarng; Kun-Jhih Lin; Hung-Wen Wei (Journal of Medical and Biological Engineering, 2022)

Genetic diversity and population structure of Curcuma alismatifolia Gagnep. accessions revealed by SSR markers - Hui-Wen Yu; Ling-Jun Ke; Yi-Lan Xiao; Si-Jia Chen; Yuan-Yuan Li; Qi-Lin Tian; Yun-He Li; Jin-Shui Lin; Luan-Mei Lu (Genetic Resources and Crop Evolution, 2022)

Probiotics and their Metabolites Reduce Oxidative Stress in Middle-Aged Mice - Wen-Yang Lin; Jia-Hung Lin; Yi-Wei Kuo; Pei-Fang Rose Chiang; Hsieh-Hsun Ho (Current Microbiology, 2022)
Aging is an irreversible physiological degradation of living organisms. Accumulated oxidative stress and dysbiosis accelerate aging. Probiotics such as Lactobacillus and Bifidobacterium and their fermented metabolites (postbiotics) have been discovered to exhibit antioxidative activities that regulate oxidative stress and protect cells from oxidative damage. We screened selected Lactobacillus and Bifidobacterium strains and their postbiotics for potential antioxidative activity by using DPPH (2,2-Diphenyl-1-picrylhydrazyl) assay. Strains with their metabolites were selected for mixed formula in experiments involving aging mice. The aged groups presented higher oxidative stress in the brain, liver, heart, and kidney than did young mice. However, treatment with probiotic strains and their postbiotics elevated antioxidative levels, especially in the high-dose probiotics plus postbiotics group. Next-generation sequencing data revealed positive microbiota alterations of Lactobacillus and Bifidobacterium and Akkermansia in the gut. Lactobacillus johnsonii and Akkermansia muciniphila exhibited effective enlargement of relative abundance. Besides, high-dose probiotics and high-dose probiotics plus postbiotics showed significant elevation in serum SCFAs, especially in butyrate. In conclusion, the formula containing Bifidobacterium animalis subsp. infantis BLI-02, Bifidobacterium breve Bv889, Bifidobacterium bifidum VDD088, B. animalis subsp. lactis CP-9, and Lactobacillus plantarum PL-02 and their metabolites may benefit aged people’s health.

Investigating microscale structural characteristics and resultant macroscale mechanical properties of loess exposed to alkaline and saline environments - Lin Wang; Wen-Chieh Cheng; Zhong-Fei Xue (Bulletin of Engineering Geology and the Environment, 2022)

Functional traits explain the consistent resistance of biodiversity to plant invasion under nitrogen enrichment - Shao‐peng Li; Pu Jia; Shu‐ya Fan; Yingtong Wu; Xiang Liu; Yani Meng; Yue Li; Wen‐sheng Shu; Jin‐tian Li; Lin Jiang (Ecology Letters, 2022)
Elton's biotic resistance hypothesis, which posits that diverse communities should be more resistant to biological invasions, has received considerable experimental support. However, it remains unclear whether such a negative diversity–invasibility relationship would persist under anthropogenic environmental change. By using the common ragweed ( Ambrosia artemisiifolia ) as a model invader, our 4‐year grassland experiment demonstrated consistently negative relationships between resident species diversity and community invasibility, irrespective of nitrogen addition, a result further supported by a meta‐analysis. Importantly, our experiment showed that plant diversity consistently resisted invasion simultaneously through increased resident biomass, increased trait dissimilarity among residents, and increased community‐weighted means of resource‐conservative traits that strongly resist invasion, pointing to the importance of both trait complementarity and sampling effects for invasion resistance even under resource enrichment. Our study provides unique evidence that considering species’ functional traits can help further our understanding of biotic resistance to biological invasions in a changing environment.

Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated Encephalopathy by Promoting Ferroptosis Through Regulating miR-9-5p/TFRC and GOT1 Axis - Xue-biao Wei; Wen-qiang Jiang; Ju-hao Zeng; Lin-qiang Huang; Hong-guang Ding; Yuan-wen Jing; Yong-li Han; Yi-chen Li; Sheng-long Chen (Molecular Neurobiology, 2022)
Sepsis can cause sepsis-associated encephalopathy (SAE), but whether SAE was induced or exacerbated by ferroptosis remains unknown. In this study, the rat sepsis model was constructed using the cecal ligation and puncture method. The blood–brain barrier (BBB) permeability was measured by Evans blue dye (EBD) in vivo. The levels of ROS, Fe ion, MDA, GSH, and GPX4 were assessed by enzyme-linked immunosorbent assay (ELISA). The exosomes isolated from serum were cultured with bEnd.3 cells for the in vitro analysis. Moreover, bEnd.3 cells cultured with 100 μM FeCl3 (iron-rich) were to simulate ferroptosis stress. The cell viability was evaluated by Cell Counting Kit-8 (CCK-8) assay. A dual-luciferase reporter gene assay was performed to confirm the relationship between miR-9-5p with NEAT1, TFRC , and GOT1 . In vivo, it is found that BBB permeability was damaged in model rats. Level of ROS, Fe ion, and MDA was increased, and level of GSH and GPX4 was decreased, which means ferroptosis was induced by sepsis. Exosome-packaged NEAT1 in serum was significantly upregulated in model rats. In vitro, it is found that NEAT1 functions as a ceRNA for miR-9-5p to facilitate TFRC and GOT1 expression. Overexpression of NEAT1 enhanced ferroptosis stress in bEnd.3 cells. Increased miR-9-5p alleviated sepsis-induced ferroptosis by suppressing the expression of TFRC and GOT1 both in vivo and in vitro. In conclusion, these findings suggest that sepsis induced high expression of serous exosome-derived NEAT1, and it might exacerbate SAE by promoting ferroptosis through regulating miR-9-5p/ TFRC and GOT1 axis.

Towards a rapid assessment of highway slope disasters by using multidisciplinary techniques - Meng-Chia Weng; Cheng-Han Lin; Wen-Jie Shiu; Wei-An Chao; Chia-Chi Chiu; Ching-Fang Lee; Wei-Kai Huang; Che-Ming Yang (Landslides, 2022)
Mega-earthquakes and extreme climate events accompanied by intrinsic fragile geology lead to numerous landslides along mountain highways in Taiwan, causing enormous life and economic losses. In this study, a system for rapid slope disaster information integration and assessment is proposed with the aim of providing information on landslide occurrence, failure mechanisms, and subsequent landslide-affected areas to the highway authority rapidly. The functionality of the proposed system is deployed into three units: (1) geohazard rapid report (GeoPORT I), (2) multidisciplinary geological survey report (GeoPORT II), and (3) site-specific landslide simulation report (GeoPORT III). After landslide occurrence, the seismology-based monitoring network rapidly provides the initial slope disaster information, including preliminary location, event magnitude, earthquake activity, and source dynamics, within an hour. Within 3 days of the landslide, a multidisciplinary geological survey is conducted to collect high-precision topographical, geological, and remote-sensing data to determine the possible failure mechanism. After integrating the aforementioned information, a full-scale three-dimensional landslide simulation based on the discrete element method is performed within 10 days to reveal the failure process and to identify the areas potentially affected by subsequent disasters through scenario modeling. Overall, the proposed system can promptly provide comprehensive and objective information to relevant authorities after the event occurrence for hazard assessment. The proposed system was validated using a landslide event in the Central Cross-Island Highway of Taiwan.

Nitrogen Fertilization and Precipitation Affected Wheat Nitrogen Use Efficiency and Yield in the Semiarid Region of the Loess Plateau in China - Jie Ren; Aixia Ren; Wen Lin; Hafeez Noor; Shahbaz Khan; Shifeng Dong; Min Sun; Zhiqiang Gao (Journal of Soil Science and Plant Nutrition, 2022)

The effect of preoperative statin treatment on acute kidney injury in elderly patients undergoing valve replacement surgery - Bing-qi Fu; Xue-biao Wei; Zedazhong Su; Ying-wen Lin; Zu-hui Ke; Tong Tan; Ji-yan Chen; Shou-hong Wang; Dan-qing Yu (European Journal of Clinical Pharmacology, 2022)

The associations of urinary DEHP metabolite levels, serum thyroid hormones, and thyroid-related genes among the adolescent students from China: a cross-sectional study - Yaming Zhao; Xinyue Song; Shuang Ding; Wen Qi; Yuezhu Zhang; Qi Xu; Tianyang Zhao; Xueting Zhang; Xu Li; Fuju Wu; Lin Ye (Environmental Science and Pollution Research, 2022)

Evaluating coupled hydromechanical behavior of anisotropic rock mass using DEM - Wen-Jie Shiu; Meng-Chia Weng; Chia-Chi Chiu; Po-Lin Wu (Bulletin of Engineering Geology and the Environment, 2022)

The Weakening Relationship between ENSO and the South China Sea Summer Monsoon Onset in Recent Decades - Peng Hu; Wen Chen; Shangfeng Chen; Lin Wang; Yuyun Liu (Advances in Atmospheric Sciences, 2022)

Morphological and Molecular Characterization of Paragonimus skrjabini Complex from Yunnan, China: A Brief Report - Qiu-Hong Shu; Shu-De Li; Ming Tian; Yong Meng; Shu-Mei-Qi He; Min Zhu; Miao-Miao Wang; Wen-Lin Wang (Acta Parasitologica, 2022)
Purpose To perform environmental sampling and molecular identification of Paragonimus in endemic regions, which may help in minimizing transmission among humans. Methods Mountain crabs from the genus Potamiscus were collected and the encysted metacercariae were extracted and subjected to morphological identification, followed by animal inoculation in Sprague–Dawley (SD) rats. After 112 days of infection, animals were killed and adult worms were extracted from lungs and muscles. The morphology of adult worms was characterized by microscopy and molecular identification was done by polymerase chain reaction, followed by sequencing of cox1 and ITS2 genes. Phylogenetic analysis was done by maximum parsimony method. Results A total of 447 crabs were captured from the streams of Tongchang Town, Jinping County, Yunnan Province, China. The infection rate was found to be 41% (186 out of 447 crabs). The metacercariae of Paragonimus skrjabini was identified by the characteristics round or spherical encysted form measuring 410 to 460 × 400 to 460 µm. After animal infection in SD rats, adults were presumptively confirmed to be P. skrjabini , which was also confirmed by gene amplification and sequence analysis of cox1 and ITS2 regions. Paragonimus skrjabini clustered with previously reported P. skrjabini from Yunnan and Vietnam. The confidence values of their branches were > 95%. Phylogenetic analysis of the ITS2 region revealed two distinct clusters with distinct geographical grouping. Phylogenetic analysis with the combined data sets reiterated the geographical grouping with P. skrjabini from Yunnan clustering with strains from Vietnam. Conclusion Metacercariae of P. skrjabini was discovered in freshwater crabs in Yunnan province, China, and the strains were phylogenetically related to P. skrjabini from Vietnam.

Prevalence, complete genome, and metabolic potentials of a phylogenetically novel cyanobacterial symbiont in the coral‐killing sponge, Terpios hoshinota - Yu‐Hsiang Chen; Hsing‐Ju Chen; Cheng‐Yu Yang; Jia‐Ho Shiu; Daphne Z. Hoh; Pei‐Wen Chiang; Wenhua Savanna Chow; Chaolun Allen Chen; Tin‐Han Shih; Szu‐Hsien Lin; Chi‐Ming Yang; James Davis Reimer; et al. (Environmental Microbiology, 2022)
Summary Terpios hoshinota is an aggressive, space‐competing sponge that kills various stony corals. Outbreaks of this species have led to intense damage to coral reefs in many locations. Here, the first large‐scale 16S rRNA gene survey across three oceans revealed that bacteria related to the taxa Prochloron , Endozoicomonas , SAR116, Ruegeria , and unclassified Proteobacteria were prevalent in T . hoshinota . A Prochloron ‐related bacterium was the most dominant and prevalent cyanobacterium in T . hoshinota . The complete genome of this uncultivated cyanobacterium and pigment analysis demonstrated that it has phycobiliproteins and lacks chlorophyll b , which is inconsistent with the definition of Prochloron . Furthermore, the cyanobacterium was phylogenetically distinct from Prochloron , strongly suggesting that it should be a sister taxon to Prochloron . Therefore, we proposed this symbiotic cyanobacterium as a novel species under the new genus Candidatus Paraprochloron terpiosi. Comparative genomic analyses revealed that ‘Paraprochloron’ and Prochloron exhibit distinct genomic features and DNA replication machinery. We also characterized the metabolic potentials of ‘Paraprochloron terpiosi’ in carbon and nitrogen cycling and propose a model for interactions between it and T. hoshinota . This study builds a foundation for the study of the T . hoshinota microbiome and paves the way for better understanding of ecosystems involving this coral‐killing sponge.

A super PPR cluster for restoring fertility revealed by genetic mapping, homocap-seq and de novo assembly in cotton - Bin Gao; Gaofeng Ren; Tianwang Wen; Haiping Li; Xianlong Zhang; Zhongxu Lin (Theoretical and Applied Genetics, 2022)

L-Theanine Ameliorated Rotenone-Induced Parkinsonism-like Symptoms in Rats - Cheng-Neng Chen; Mao-Hsien Wang; Hung-Sheng Soung; Shu-Mei Chen; Chih-Hsiang Fang; Yi-Wen Lin; Hsiang-Chien Tseng (Neurotoxicity Research, 2022)

Interferon-induced transmembrane protein 2 promotes epithelial-mesenchymal transition by activating transforming growth factor-β1/small mother against decapentaplegic 2 signaling in gastric cancer - Yonggang Liu; Minyu Zhou; Jianhua Wu; Zhaowei Wen; Yisheng Fang; Li Lin; Meihua Luo; Li Sun; Wangjun Liao (Molecular Biology Reports, 2022)

Comparatively analyzing the liver-specific transcriptomic profiles in Kunming mice afflicted with streptozotocin- and natural food-induced type 2 diabetes mellitus - Yanjun Wu; Xiangxing Zhu; Arome Solomon Odiba; Zisheng Lin; Jiancong Wen; Daoyuan Gong; Jing Liang; Shuguang Wu; Ganqiu Lan (Molecular Biology Reports, 2022)

Synthesis, antifungal activity and 3D-QSAR study of novel acyl thiourea compounds containing gem-dimethylcyclopropane ring - Mei Huang; Min Huang; Xiu Wang; Wen-Gui Duan; Gui-Shan Lin; Fu-Hou Lei (Molecular Diversity, 2022)

Structure related α-glucosidase inhibitory activity and molecular docking analyses of phenolic compounds from Paeonia suffruticosa - Po-Chun Chen; Bongani Sicelo Dlamini; Chiy-Rong Chen; Yueh-Hsiung Kuo; Wen-Ling Shih; Yun-Sheng Lin; Chien-Hsing Lee; Chi-I Chang (Medicinal Chemistry Research, 2022)

Phactr1 negatively regulates bone mass by inhibiting osteogenesis and promoting adipogenesis of BMSCs via RhoA/ROCK2 - Wei Lin; Zhipeng Chen; Xiaoyi Mo; Shengli Zhao; Zhenxing Wen; Wing Hoi Cheung; Dan Fu; Bailing Chen (Journal of Molecular Histology, 2022)

Common Subtype of Small Renal Mass MR Imaging Characterisation: A Medical Center Experience in Taiwan - Ming-Cheng Liu; Yi-Jui Liu; Yen-Ting Lin; Siu-Wan Hung; Jyh-Wen Chai; Si-Wa Chan; Kun-Yuan Chiu; Ya-Ling Tsou (Journal of Medical and Biological Engineering, 2022)
Purpose Many studies have shown that multiparametric magnetic resonance imaging (MRI) may be helpful for differentiating malignant renal cell carcinomas (RCCs) from benign lesions. However, the key imaging characteristics that differ between malignant and benign tumors still require further discussion. Methods We analyzed 60 adult patients diagnosed with 72 small renal masses (SRMs) who received preoperative MRI from 2014 to 2019 at a hospital in Taiwan. The MRI features included conventional MRI parameters, diffusion-weighted imaging (DWI) data, and dynamic contrast-enhanced (DCE) patterns, which were documented and compared among the four common subtypes: clear cell RCC (ccRCC), papillary RCC (pRCC), angiomyolipoma (AML) and other types of RCC. The apparent diffusion coefficient (ADC) values of high- and low-grade RCCs were also analyzed. Results The results show that ccRCC had higher T2-weighted signal intensity than the other three subgroups, a higher arterial wash-in index (AWI) and ADC value than AML and pRCC, and manifested a plateau ( n = 9, 25%) or washout (n = 27, 75%) enhancement pattern. AMLs exhibited more intravoxel fat than the other three subtype groups, and half of the AMLs (6 in 12) contained bulk fat. pRCC demonstrated a more progressive (n = 3, 60%) enhancement pattern than the other three subgroups. The ADC value of high-grade RCCs was significantly lower than that of low-grade RCCs. Conclusion These findings may indicate that multiparametric MRI is useful in differentiating among four common pathological types of SRMs, and the ADC value may be helpful in evaluating the histological grade of malignancy.

Feasibility and usability of a mobile health tool on anticoagulation management for patients with atrial fibrillation: a pilot study - Chi Zhang; Mang-Mang Pan; Na Wang; Wei-Wei Wang; Zheng Li; Zhi-Chun Gu; Hou-Wen Lin (European Journal of Clinical Pharmacology, 2022)

Study of the operative conditions and the optimum amount of municipal incinerator bottom ash for the obtainment of ceramic floor tiles - Deng-Fong Lin; Kuo-Liang Lin; Show-Ing Shieh; Chia-Wen Chen (Environmental Science and Pollution Research, 2022)

Higher sequestration of wheat versus maize crop carbon in soils under rotations - Zheng-Rong Kan; Shou-Wei Han; Wen-Xuan Liu; Xin Zhao; Rattan Lal; Hai-Lin Zhang (Environmental Chemistry Letters, 2022)

Effects of cryopreservation on the ultrastructure of coral larvae - Luca Cirino; Sujune Tsai; Li-Hsueh Wang; Wen-Chung Hsieh; Cheng-Liang Huang; Zhi-Hong Wen; Chiahsin Lin (Coral Reefs, 2022)

Evaluation of suitable qRT-PCR normalization genes for various citrus rootstocks - Wen He; Rui Xie; Huan Li; Yan Wang; Qing Chen; Yuanxiu Lin; Yunting Zhang; Ya Luo; Yong Zhang; Haoru Tang; Xiaorong Wang (Plant Biotechnology Reports, 2022)

The responses of detoxification enzyme and gene expression in western flower thrips, Frankliniella occidentalis, to new challenging hosts - Wen-Bo Yue; Jun-Rui Zhi; Li Liu; Xiao-Lin Hou; Mao Ye (Arthropod-Plant Interactions, 2022)

Large‐scale circulation features responsible for different types of extreme high temperatures with extreme coverage over South China - Wenting Lin; Ruidan Chen; Zhiping Wen; Wei Chen (International Journal of Climatology, 2022)
This study classifies the summer extreme high temperatures (EHT) over South China into Day‐EHT, Night‐EHT and Mixed‐EHT (corresponding to EHT with extreme coverage only in daytime, only at night and both in daytime and at night) and compares their associated circulation patterns. All types of EHT are associated with the intensification and expansion of western Pacific subtropical high (WPSH). Concurrently, anomalous subsidence occurs over South China, which reduces the cloud cover and favours daytime warming. However, different types of EHT feature different circulation configurations. Day‐EHT are influenced by the northwestward‐extending WPSH and tropical cyclones, manifesting an abnormal anticyclonic‐cyclonic pair. Anomalous northeasterly winds dominate over South China, which cause lower humidity and faster heat dissipation and thus the EHT disappear at night. Night‐EHT are related to the westward‐extending WPSH and intensified East Asian westerly trough, presenting a subtropical anticyclonic anomaly and a mid‐latitude cyclonic anomaly. Anomalous southwesterly and northerly flows meet around South China, favouring more water vapour convergence in situ. The above‐normal humidity results in smaller amplitude of cloud cover reduction and weaker daytime warming compared to Day‐EHT, but favours heat maintenance and Night‐EHT. Moreover, the mid‐high‐latitude wave train preceding Day‐EHT (Night‐EHT) lies more northward (southward) with the upstream high‐pressure anomaly occurring around the Ural Mountains (Caspian Sea). Mixed‐EHT combine the anomalies for Day‐EHT and Night‐EHT and weak humidity anomaly occurs over South China, thus the daytime EHT could persist until night albeit cools down slightly. These distinguished features indicate that different types of EHT should be considered separately for better forecast and projection of EHT.

Future projections of precipitation, surface temperatures and drought events over the monsoon transitional zone in China from bias‐corrected CMIP6 models - Jinling Piao; Wen Chen; Lin Wang; Shangfeng Chen (International Journal of Climatology, 2022)
Bias‐corrected monthly precipitation and surface temperature datasets are constructed for the monsoon transitional zone (MTZ) in China during 1965–2100 based on 21 coupled climate models from phase 6 of the Coupled Model Intercomparison Project (CMIP6) using the equi‐ratio and equidistant cumulative distribution function quantile‐based mapping methods (equi‐ratio cumulative distribution function [ERCDF] and equidistant cumulative distribution function [EDCDF]), respectively. The efficiencies of the two methods are verified via cross‐validation by the jack‐knife method, and the biases are remarkably reduced compared to those of the raw model outputs. Then, the bias‐corrected model outputs are applied to future projections of precipitation, surface temperatures and drought events under the medium (SSP2‐4.5) and high (SSP5‐8.5) shared socioeconomic pathway scenarios. The obtained results present pronounced increases in both the projected annual mean precipitation and temperature fields for the model ensemble mean. In accompany, the MTZ is predicted to become drier in the three future periods; this result was attributed to the dramatic increases in semiarid events and to the decreases in humid events. The drought tension showed more rapid development under SSP585 than under the other scenario, with comparable occurrence frequencies of relatively wet and dry events in the long‐term period, posing a serious threat to regional sustainable development.

Mechanisms of soil organic carbon stability and its response to no‐till: A global synthesis and perspective - Zheng‐Rong Kan; Wen‐Xuan Liu; Wen‐Sheng Liu; Rattan Lal; Yash Pal Dang; Xin Zhao; Hai‐Lin Zhang (Global Change Biology, 2022)
Mechanisms of soil organic carbon (SOC) stabilization have been widely studied due to their relevance in the global carbon cycle. No‐till (NT) has been frequently adopted to sequester SOC; however, limited information is available regarding whether sequestered SOC will be stabilized for long term. Thus, we reviewed the mechanisms affecting SOC stability in NT systems, including the priming effects (PE), molecular structure of SOC, aggregate protection, association with soil minerals, microbial properties, and environmental effects. Although a more steady‐state molecular structure of SOC is observed in NT compared with conventional tillage (CT), SOC stability may depend more on physical and chemical protection. On average, NT improves macro‐aggregation by 32.7%, and lowers SOC mineralization in macro‐aggregates compared with CT. Chemical protection is also important due to the direct adsorption of organic molecules and the enhancement of aggregation by soil minerals. Higher microbial activity in NT could also produce binding agents to promote aggregation and the formation of metal‐oxidant organic complexes. Thus, microbial residues could be stabilized in soils over the long term through their attachment to mineral surfaces and entrapment of aggregates under NT. On average, NT reduces SOC mineralization by 18.8% and PE intensities after fresh carbon inputs by 21.0% compared with CT ( p Q 10 ) is observed in NT due to greater Q 10 in macro‐aggregates, an increase of soil moisture regime in NT could potentially constrain the improvement of Q 10 . This review improves process‐based understanding of the physical and chemical mechanism of protection that can act, independently or interactively, to enhance SOC preservation. It is concluded that SOC sequestered in NT systems is likely to be stabilized over the long term.

Isolation and structural elucidation of a low-molecular-weight polysaccharide from the roots of Panax ginseng C. A. Meyer - Bin Zhao; Xin-Ying Wang; Wen Luo; Yue Lin; Chong-Ning Lv; Jin-Cai Lu (Natural Product Research, 2022)

Effect of Sodium Salicylate on Calcium Currents and Exocytosis in Cochlear Inner Hair Cells: Implications for Tinnitus Generation - Ting Fan; Meng-Ya Xiang; Ruo-Qiao Zhou; Wen Li; Li-Qin Wang; Peng-Fei Guan; Geng-Lin Li; Yun-Feng Wang; Jian Li (Neuroscience Bulletin, 2022)

Adaptations of Plutella xylostella adult females and larvae to waxy host plants - Jing-Yun Zhu; Zhong-Wen Xiang; Shi-Ze Zhang; Lin-Nan Wu; Tong-Xian Liu (Journal of Pest Science, 2022)

Celastrol attenuates chronic constrictive injury-induced neuropathic pain and inhibits the TLR4/NF-κB signaling pathway in the spinal cord - Gui-juan Jin; Xuehuizi Peng; Zhi-Guo Chen; Yu-lin Wang; Wen-jun Liao (Journal of Natural Medicines, 2022)

Regulatory role of miR-129 and miR-384-5p on apoptosis induced by oxygen and glucose deprivation in PC12 cell - Hui-Lin Guan; Yue Guan; Wen-Yuan Li; Jia-Wei Liu; Yu-Jia Zheng; Yan-Zhong Guan; Hong-Feng Liu; Li-Xin Guan; Feng-Guo Zhai (Experimental Brain Research, 2022)

Di(2-ethylhexyl) phthalate (DEHP) and thyroid: biological mechanisms of interference and possible clinical implications - Xueting Zhang; Wen Qi; Qi Xu; Xu Li; Liting Zhou; Lin Ye (Environmental Science and Pollution Research, 2022)

Adenine base-editing-mediated exon skipping induces gene knockout in cultured pig cells - Xiang-xing Zhu; Jia-sheng Pan; Tao Lin; Ye-cheng Yang; Qiu-yan Huang; Shuai-peng Yang; Zi-xiao Qu; Zi-sheng Lin; Jian-cong Wen; Ai-fen Yan; Juan Feng; Lian Liu; et al. (Biotechnology Letters, 2022)

Sabulicella rubraurantiaca gen. nov., sp. nov., a new member of the family Acetobacteraceae, isolated from desert soil - Zhi-Liang Lin; Shuai Li; Qi-Chuang Wei; Wen-Hui Lian; Chun-Yan Lu; Lu Xu; Li-Nan Huang; Lei Dong; Wen-Jun Li (Archives of Microbiology, 2022)

Mitogenomes provide new insights into the evolutionary history of Prodiamesinae (Diptera: Chironomidae) - Xiao‐Long Lin; Yan‐Min Zhao; Li‐Ping Yan; Wen‐Bin Liu; Wen‐Jun Bu; Xin‐Hua Wang; Chen‐Guang Zheng (Zoologica Scripta, 2022)
Evolutionary analysis of Prodiamesinae has long been impeded by lack of information, and its phylogenetic relationship with Orthocladiinae remains questionable. Here, ten complete mitochondrial genomes (mitogenomes) of Orthocladiinae sensu lato were newly sequenced, including three Prodiamesinae species and seven Orthocladiinae species. Coupled with published mitogenomes, a total of 12 mitogenomes of Orthocladiinae sensu lato were selected for a comparative mitogenomic analysis and phylogenetic reconstruction. Mitogenomes of Orthocladiinae sensu lato are conserved in structure, and all genes arrange the same gene order as the ancestral insect mitogenome. Nucleotide composition is highly biased, and the control region displayed the highest A + T content. All protein‐coding genes are under purifying selection, and the ATP8 evolves at the fastest rate. In addition, the mitogenomes of Orthocladiinae sensu lato are highly conserved, and they are practically useful for phylogenetic inference, suggesting a re‐classification of Orthocladiinae by sinking Prodiamesinae as a subgroup of Orthocladiinae.

Responses of soil pH to no‐till and the factors affecting it: A global meta‐analysis - Xin Zhao; Cong He; Wen‐Sheng Liu; Wen‐Xuan Liu; Qiu‐Yue Liu; Wei Bai; Li‐Jun Li; Rattan Lal; Hai‐Lin Zhang (Global Change Biology, 2022)
No‐till (NT) is a sustainable option because of its benefits in controlling erosion, saving labor, and mitigating climate change. However, a comprehensive assessment of soil pH response to NT is still lacking. Thus, a global meta‐analysis was conducted to determine the effects of NT on soil pH and to identify the influential factors and possible consequences based on the analysis of 114 publications. When comparing tillage practices, the results indicated an overall significant decrease by 1.33 ± 0.28% in soil pH under NT than that under conventional tillage ( p −1 (−1.83%), or crop residue retention (−1.52%). Changes in organic matter decomposition under undisturbed soil and with crop residue retention might lead to a higher concentration of H + and lower of basic cations (i.e., calcium, magnesium, and potassium), which decrease the soil pH, and consequently, impact nutrient dynamics (i.e., soil phosphorus) in the surface layer under NT. Furthermore, soil acidification may be aggravated by NT within site‐specific conditions and improper fertilizer and crop residue management and consequently leading to adverse effects on soil nutrient availability. Thus, there is a need to identify strategies to ameliorate soil acidification under NT to minimize the adverse consequences.

Investigating the Transcriptomic and Expression Presence-Absence Variation Exist in Japanese Eel (Anguilla japonica), a Primitive Teleost - Yung-Sen Huang; Chung-Yen Lin; Wen-Chih Cheng (Marine Biotechnology, 2021)

Intramyocardial injection of human adipose-derived stem cells ameliorates cognitive deficit by regulating oxidative stress–mediated hippocampal damage after myocardial infarction - Tsung-Ming LEE; Cheng-Che LEE; Horng-Jyh HARN; Tzyy-Wen Chiou; Ming-Hsi CHUANG; Chun-Hung CHEN; Chi-Hsuan CHUANG; Po-Cheng LIN; Shinn-Zong LIN (Journal of Molecular Medicine, 2021)
Cognitive impairment is a serious side effect of post-myocardial infarction (MI) course. We have recently demonstrated that human adipose-derived stem cells (hADSCs) ameliorated myocardial injury after MI by attenuating reactive oxygen species (ROS) levels. Here, we studied whether the beneficial effects of intramyocardial hADSC transplantation can extend to the brain and how they may attenuate cognitive dysfunction via modulating ROS after MI. After coronary ligation, male Wistar rats were randomized via an intramyocardial route to receive either vehicle, hADSC transplantation (1 × 10 6 cells), or the combination of hADSCs and 3-Morpholinosydnonimine (SIN-1, a peroxynitrite donor). Whether hADSCs migrated into the hippocampus was assessed by using human-specific primers in qPCR reactions. Passive avoidance test was used to assess cognitive performance. Postinfarction was associated with increased oxidative stress in the myocardium, circulation, and hippocampus. This was coupled with decreased numbers of dendritic spines as well as a significant downregulation of synaptic plasticity consisting of synaptophysin and PSD95. Step-through latency during passive avoidance test was impaired in vehicle-treated rats after MI. Intramyocardial hADSC injection exerted therapeutic benefits in improving cardiac function and cognitive impairment. None of hADSCs was detected in rat’s hippocampus at the 3rd day after intramyocardial injection. The beneficial effects of hADSCs on MI-induced histological and cognitive changes were abolished after adding SIN-1. MI-induced ROS attacked the hippocampus to induce neurodegeneration, resulting in cognitive deficit. The remotely intramyocardial administration of hADSCs has the capacity of improved synaptic neuroplasticity in the hippocampus mediated by ROS, not the cell engraftment, after MI. Key messages Human adipose-derived stem cells (hADSCs) ameliorated injury after myocardial infarction by attenuating reactive oxygen species (ROS) levels. Intramyocardial administration of hADSCs remotely exerted therapeutic benefits in improving cognitive impairment after myocardial infarction. The improved synaptic neuroplasticity in the hippocampus was mediated by hADSC-inhibiting ROS, not by the stem cell engraftment.

Electrical Impedance Tomography Analysis Between Two Similar Respiratory System Compliance During Decremetal PEEP Titration in ARDS Patients - Po-Lan Su; Wei-Chieh Lin; Yen-Fen Ko; Kuo-Sung Cheng; Chang-Wen Chen (Journal of Medical and Biological Engineering, 2021)
Purpose The positive end-expiratory pressure (PEEP) level with best respiratory system compliance (Crs) is frequently used for PEEP selection in acute respiratory distress syndrome (ARDS) patients. On occasion, two similar best Crs (where the difference between the Crs of two PEEP levels is < 1 ml/cm H 2 O) may be identified during decremental PEEP titration. Selecting PEEP under such conditions is challenging. The aim of this study was to provide supplementary rationale for PEEP selection by assessing the global and regional ventilation distributions between two PEEP levels in this situation. Methods Eight ARDS cases with similar best Crs at two different PEEP levels were analyzed using examination-specific electrical impedance tomography (EIT) measures and airway stress index (SIaw). Five Crs were measured at PEEP values of 25 cm H 2 O (PEEP 25 ), 20 cm H 2 O (PEEP 20 ), 15 cm H 2 O (PEEP H ), 11 cm H 2 O (PEEP I ), and 7 cm H 2 O (PEEP L ). The higher PEEP value of the two PEEPs with similar best Crs was designated as PEEP upper , while the lower designated as PEEP lower . Results PEEP H and PEEP I shared the best Crs in two cases, while similar Crs was found at PEEP I and PEEP L in the remaining six cases. SIaw was higher with PEEP upper as compared to PEEP lower (1.06 ± 0.10 versus 0.99 ± 0.09, p = 0.05). Proportion of lung hyperdistension was significantly higher with PEEP upper than PEEP lower (7.0 ± 5.1% versus 0.3 ± 0.5%, p = 0.0002). In contrast, proportion of recruitable lung collapse was higher with PEEP lower than PEEP upper (18.6 ± 4.4% versus 5.9 ± 3.7%, p < 0.0001). Cyclic alveolar collapse and reopening during tidal breathing was higher at PEEP lower than PEEP upper (34.4 ± 19.3% versus 16.0 ± 9.1%, p = 0.046). The intratidal gas distribution (ITV) index was also significantly higher at PEEP lower than PEEP upper (2.6 ± 1.3 versus 1.8 ± 0.7, p = 0.042). Conclusions PEEP upper is a rational selection in ARDS cases with two similar best Crs. EIT provides additional information for the selection of PEEP in such circumstances.

A comparison of atmospheric geochemistry through lichens from volcanic and non-volcanic areas, north Taiwan - Le-Qi Lin; Hsueh-Yu Lu; Ju-Lien Pi; Tai-Sheng Liou; Wen-Fu Chen; Pei-Shan Hsieh (Journal of Earth System Science, 2021)

Genome-wide identification and expression analysis of glycosyltransferase gene family 1 in Quercus robur L. - Jie Zhang; Li-Mei Lin; Wen-Wen Cheng; Xin Song; Yue-Hong Long; Zhao-Bin Xing (Journal of Applied Genetics, 2021)

Optimizing the Wheat Seeding Rate for Wide-Space Sowing to Improve Yield and Water and Nitrogen Utilization - Zhixin Wang; Shahbaz Khan; Min Sun; Aixia Ren; Wen Lin; Pengcheng Ding; Hafeez Noor; Shaobo Yu; Yu Feng; Qiang Wang; Zhiqiang Gao (International Journal of Plant Production, 2021)

Mechanisms of cardiovascular toxicity induced by PM2.5: a review - Tianyang Zhao; Wen Qi; Pan Yang; Liwei Yang; Yanbin Shi; Liting Zhou; Lin Ye (Environmental Science and Pollution Research, 2021)

Effects of biochar on the growth of Vallisneria natans in surface flow constructed wetland - Chaoqun Zheng; Xuanwen Zhang; Lin Gan; Zhaofang He; Jinling Zhu; Wen Zhang; Yan Gao; Liuyan Yang (Environmental Science and Pollution Research, 2021)

Mean states and future projections of precipitation over the monsoon transitional zone in China in CMIP5 and CMIP6 models - Jinling Piao; Wen Chen; Shangfeng Chen; Hainan Gong; Lin Wang (Climatic Change, 2021)

Releasing Characteristics and Biological Toxicity of the Heavy Metals from Waste of Mercury-Thalliummine in Southwest Guizhou of China - Jichang Wen; Yonggui Wu; Qian Lu; Xinlong Li; Lin Yang; Zhibin Duan (Bulletin of Environmental Contamination and Toxicology, 2021)

Nitrogen absorption by alpine forage species based on 15N tracer technique in a hydroponic culture - Yan-fang Liu; Wen-ying Wang; Xiao-lin Ma; Pan Liu; Hua-kun Zhou; Zhe Chen; Chong Yang; Jin-hong Guan (Journal of Mountain Science, 2021)

Evaluation of FY-3B Reprocessed OLR Data in the Asian—Australian Monsoon Region during 2011–2019: Comparison with NOAA OLR - Lin Liu; Wanchun Zhang; Wen Chen; Renguang Wu; Lin Wang (Journal of Meteorological Research, 2021)

Correction to: 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Bernard R. Agwanda; Rim Al Kubrusli; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Christopher F. Basler; et al. (Archives of Virology, 2021)

Complete genome sequence of a putative novel ilarvirus isolated from Eleocharis dulcis - Lanqing Lv; Xinyang Wu; Jiajia Weng; Yuchao Lai; Kelei Han; Yuwen Lu; Jiejun Peng; Lin Lin; Shaofei Rao; Guanwei Wu; Jianping Chen; Hongying Zheng; et al. (Archives of Virology, 2021)

2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Bernard R. Agwanda; Rim Al Kubrusli; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Christopher F. Basler; et al. (Archives of Virology, 2021)

Two new diterpenoids with their antiproliferative activities from the supercritical fluid extraction of Croton crassifolius root - Chao Liu; Rui-rui Zhang; Qing-lin Niu; Jing Zhang; Mu-xuan Wang; Na-na Meng; Qing Wang; Jin-yue Sun; Wen-liang Wang (Natural Product Research, 2021)

Phenolic glycosides and flavonoids with antioxidant and anticancer activities from Desmodium caudatum - Qian-Nan Xu; Dan Zhu; Guang-Hui Wang; Ting Lin; Cui-Ling Sun; Rong Ding; Wen-Jing Tian; Hai-Feng Chen (Natural Product Research, 2021)

Identification and antimicrobial properties of a new alkaloid produced by marine-derived Verrucosispora sp. FIM06-0036 - Ming-Hong Chen; Yun-Yang Lian; Dong-Sheng Fang; Li Chen; Jia Jia; Wen-Long Zhang; Ru Lin; Yang Xie; Hong-Kai Bi; Hong Jiang (Natural Product Research, 2021)

Geo-structures and deformation-failure characteristics of rockslide areas near the Baige landslide scar in the Jinsha River tectonic suture zone - Shi-lin Zhang; Yue-ping Yin; Xie-wen Hu; Wen-pei Wang; Zong-liang Li; Xin-ming Wu; Gang Luo; Sai-nan Zhu (Landslides, 2021)

Effects of Low‐dose Mercury Exposure in Newborns on mRNA Expression Profiles - Haohao Liu; Chanchan Zhang; Fuli Wen; Lin Feng; Huiqun Wang; Wenjuan Wang; Ping Li (Bulletin of Environmental Contamination and Toxicology, 2021)

Cultural characteristics and geospatial distribution of landscape ecology in the perspective of regional culture - Wanying Yang; Baogang Lin; Chao Wen (Arabian Journal of Geosciences, 2021)

Two new cephalochromin derivative from the Alternaria sp. ZG22 - Xin-Ming Song; Xue-Ming Zhou; Ya-Ling Li; Li-Bing Huang; Cai-Cui Chen; Yan Gao; Lin He; Xiao-qun Mao; Bing Chen; Jing-Wen Liu; Hui-Jie Liu; Xiao-Ping Song; et al. (Natural Product Research, 2021)

Complement C3 Aggravates Post-epileptic Neuronal Injury Via Activation of TRPV1 - Guang-Tong Jiang; Lin Shao; Shuo Kong; Meng-Liu Zeng; Jing-Jing Cheng; Tao-Xiang Chen; Song Han; Jun Yin; Wan-Hong Liu; Xiao-Hua He; Yu-Min Liu; Lanzi Gongga; et al. (Neuroscience Bulletin, 2021)

Investigation of biofilm formation in methicillin-resistant Staphylococcus aureus associated with bacteraemia in a tertiary hospital - Wen Kiong Niek; Cindy Shuan Ju Teh; Nuryana Idris; Kwai Lin Thong; Soo Tein Ngoi; Sasheela Sri La Sri Ponnampalavanar (Folia Microbiologica, 2021)

Revisiting a trophic overlap-based measure for species uniqueness in ecological networks - Wen-Hsien Lin; Wei-Chung Liu (Community Ecology, 2021)

Protective Effects of Sodium Para-aminosalicylic Acid on Manganese-Induced Damage in Rat Pancreas - Xiaojuan Zhu; Bingyan Xie; Dianyin Liang; Wenxia Qin; Lin Zhao; Yue Deng; Pingjing Wen; Fang Xu; Michael Aschner; Yueming Jiang; Shiyan Ou (Biological Trace Element Research, 2021)

Exercise renovates H2S and Nrf2-related antioxidant pathways to suppress apoptosis in the natural ageing process of male rat cortex - Jing-Ying Lin; Tsung-Jung Ho; Bruce Chi-Kang Tsai; Chien-Yi Chiang; Hui-Chuan Kao; Wei-Wen Kuo; Ray-Jade Chen; Vijaya Padma Viswanadha; Chi-Wen Huang; Chih-Yang Huang (Biogerontology, 2021)

Sandaracinobacteroides hominis gen. nov., sp. nov., isolated from human skin - Ping-Hua Qu; Hai-Min Luo; Jun-Hui Feng; Song Li; Cha Chen; Lei Dong; Yu-Zhen Ming; Wen-Jun Li; Ying Lin (Archives of Microbiology, 2021)

Development of light-weight hollow constructional materials through microbial-induced calcium carbonate precipitation - Huang Wei; Kejun Wen; Shihui Liu; Lin Li; Farshad Amini (Arabian Journal of Geosciences, 2021)

Experimental study on integrated and autonomous conductivity-temperature-depth (CTD) sensor applied for underwater glider - Bin Lv; Hai-lin Liu; Yi-fan Hu; Cheng-xuan Wu; Jie Liu; Hai-jing He; Jie Chen; Jian Yuan; Zhao-wen Zhang; Lin Cao; Hui Li (Marine Georesources & Geotechnology, 2021)

The ATP Level in the mPFC Mediates the Antidepressant Effect of Calorie Restriction - Qian Wang; Ying Kong; Song Lin; Ding-Yu Wu; Jian Hu; Lang Huang; Wen-Si Zang; Xiao-Wen Li; Jian-Ming Yang; Tian-Ming Gao (Neuroscience Bulletin, 2021)

Growth Differentiation Factor-15 Produces Analgesia by Inhibiting Tetrodotoxin-Resistant Nav1.8 Sodium Channel Activity in Rat Primary Sensory Neurons - Wei Lin; Wen-Wen Zhang; Ning Lyu; Hong Cao; Wen-Dong Xu; Yu-Qiu Zhang (Neuroscience Bulletin, 2021)
Growth differentiation factor 15 (GDF-15) is a member of the transforming growth factor-β superfamily. It is widely distributed in the central and peripheral nervous systems. Whether and how GDF-15 modulates nociceptive signaling remains unclear. Behaviorally, we found that peripheral GDF-15 significantly elevated nociceptive response thresholds to mechanical and thermal stimuli in naïve and arthritic rats. Electrophysiologically, we demonstrated that GDF-15 decreased the excitability of small-diameter dorsal root ganglia (DRG) neurons. Furthermore, GDF-15 concentration-dependently suppressed tetrodotoxin-resistant sodium channel Nav1.8 currents, and shifted the steady-state inactivation curves of Nav1.8 in a hyperpolarizing direction. GDF-15 also reduced window currents and slowed down the recovery rate of Nav1.8 channels, suggesting that GDF-15 accelerated inactivation and slowed recovery of the channel. Immunohistochemistry results showed that activin receptor-like kinase-2 (ALK2) was widely expressed in DRG medium- and small-diameter neurons, and some of them were Nav1.8-positive. Blockade of ALK2 prevented the GDF-15-induced inhibition of Nav1.8 currents and nociceptive behaviors. Inhibition of PKA and ERK, but not PKC, blocked the inhibitory effect of GDF-15 on Nav1.8 currents. These results suggest a functional link between GDF-15 and Nav1.8 in DRG neurons via ALK2 receptors and PKA associated with MEK/ERK, which mediate the peripheral analgesia of GDF-15.

Acute associations between air pollution on premature rupture of membranes in Hefei, China - Chao Zhang; Sha Li; Gan-lan Guo; Jing-wen Hao; Peng Cheng; Li-lin Xiong; Shu-ting Chen; Ji-yu Cao; Yu-wen Guo; Jia-hu Hao (Environmental Geochemistry and Health, 2021)

Viable and Heat-Killed Probiotic Strains Improve Oral Immunity by Elevating the IgA Concentration in the Oral Mucosa - Wen-Yang Lin; Yi-Wei Kuo; Ching-Wei Chen; Yu-Fen Huang; Chen-Hung Hsu; Jia-Hung Lin; Cheng-Ruei Liu; Jui-Fen Chen; Ko-Chiang Hsia; Hsieh-Hsun Ho (Current Microbiology, 2021)
Oral-nasal mucosal immunity plays a crucial role in protecting the body against bacterial and viral invasion. Safe probiotic products have been used to enhance human immunity and oral health. In this study, we verified the beneficial effects of mixed viable probiotic tablets, consisting of Lactobacillus salivarius subsp. salicinius AP-32, Bifidobacterium animalis subsp. lactis CP-9, and Lactobacillus paracasei ET-66, and heat-killed probiotic tablets, consisting of L. salivarius subsp. salicinius AP-32 and L. paracasei ET-66, on oral immunity among 45 healthy participants. Participants were randomly divided into viable probiotic, heat-killed probiotic, and placebo groups. The administration of treatment lasted for 4 weeks. Saliva samples were collected at Weeks 0, 2, 4, and 6, and Lactobacillus , Bifidobacterium and Streptococcus mutans populations and IgA concentration were measured. IgA concentrations, levels of TGF-beta and IL-10 in PBMCs cells were quantified by ELISA method. Results showed that salivary IgA levels were significantly increased on administration of both the viable (119.30 ± 12.63%, *** P < 0.001) and heat-killed (116.78 ± 12.28%, *** P < 0.001) probiotics for 4 weeks. Among three probiotic strains, AP-32 would effectively increase the levels of TGF-beta and IL-10 in PBMCs. The oral pathogen Streptococcus mutans was significantly reduced on viable probiotic tablet administration (49.60 ± 31.01%, *** P < 0.001). The in vitro antibacterial test confirmed that viable probiotics effectively limited the survival rate of oral pathogens. Thus, this clinical pilot study demonstrated that oral probiotic tablets both in viable form or heat-killed form could exert beneficial effects on oral immunity via IL-10, TGB-beta mediated IgA secretion. The effective dosage of viable probiotic content in the oral tablet was 10 9 CFUs/g and the heat-killed oral tablet was 1 × 10 10 cells/g.

Seasonal variation of flavonoid metabolites in leaves of Liquidambar formosana ‘Nanlinhong’ trees revealed by UPLC-ESI–MS/MS - Jiu-Xin Lai; Fu-Rong Lin; Ping Huang; Wen-Ying Guo; Lie-Bao Han; Yong-Qi Zheng (Brazilian Journal of Botany, 2021)

Application of the modified cytosine base-editing in the cultured cells of bama minipig - Jia-sheng Pan; Zi-sheng Lin; Jian-cong Wen; Jian-feng Guo; Xia-hui Wu; Ying-ying Liu; Wen-jun Lai; Qi-ying Liang; Yong-shi Xie; Yi-rou Chen; Yi-hong Chen; Ai-fen Yan; et al. (Biotechnology Letters, 2021)

Flavobacterium difficile sp. nov., isolated from a freshwater waterfall - Wen-Ming Chen; Ya-Xiu You; Chiu-Chung Young; Shih-Yao Lin; Shih-Yi Sheu (Archives of Microbiology, 2021)

The Macrobrachium rosenbergii nodavirus: a detailed review of structure, infectivity, host immunity, diagnosis and prevention - Ken Fong Chen; Wen Siang Tan; Lin Kooi Ong; Syafiq Asnawi Zainal Abidin; Iekhsan Othman; Beng Ti Tey; Ronald Fook Seng Lee (Reviews in Aquaculture, 2021)
The Macrobrachium rosenbergii nodavirus causes white tail disease, which primarily infects giant freshwater prawns, Macrobrachium rosenbergii . The infection leads to almost 100% mortality in post‐larvae, causing significant economic losses in aquaculture farms. To develop effective measures against outbreaks, a good understanding of the virus is essential. In this review, we discuss key aspects of the Macrobrachium rosenbergii nodavirus including its structure, mechanisms of transmission and infection and common strategies for detection and prevention of outbreaks. Structurally, cryogenic electron microscopy revealed that the nodavirus has a T = 3 icosahedral structure with dimeric blade‐like spikes on its surface. Homology modelling comparing wild‐type and enzymatically cleaved Macrobrachium rosenbergii nodavirus‐like particles revealed the significance of these spikes or protruding domains for binding. In vitro and in vivo studies have identified key aspects of Macrobrachium rosenbergii nodavirus infectivity, including (i) the viral binding targets such as transglutaminase and caveolin‐1, (ii) utilisation of B2‐like proteins in promoting infectivity and intracellular migration, (iii) replication mechanisms and (iv) co‐infection with the extra small virus. Though susceptible at a post‐larvae stage, adult Macrobrachium rosenbergii is immune to Macrobrachium rosenbergii nodavirus infection. During outbreaks, polymerase chain reaction and in situ hybridisation‐based detection techniques are commonly used to identify infected populations. Currently, the most useful strategies for an outbreak are physical biosecurity measures and prophylaxis such as vaccination and immunostimulants. Finally, critical gaps in research include development of immortalised shrimp cell models, elucidation of time‐resolved protein changes post‐infection and development of therapies to treat infections to mitigate economic losses during outbreaks.

Effects of ultrasound on functional properties, structure and glycation properties of proteins: a review - Derong Lin; Qiuting Zhang; Lijuan Xiao; Yichen Huang; Zhengfang Yang; Zhijun Wu; Zongcai Tu; Wen Qin; Hong Chen; Dingtao Wu; Qing Zhang; Suqing Li (Critical Reviews in Food Science and Nutrition, 2021)

Genome-wide association mapping for agronomic traits in an 8-way Upland cotton MAGIC population by SLAF-seq - Cong Huang; Chao Shen; Tianwang Wen; Bin Gao; De Zhu; Dingguo Li; Zhongxu Lin (Theoretical and Applied Genetics, 2021)

Geographic modeling and simulation systems for geographic research in the new era: Some thoughts on their development and construction - Min Chen; Guonian Lv; Chenghu Zhou; Hui Lin; Zaiyang Ma; Songshan Yue; Yongning Wen; Fengyuan Zhang; Jin Wang; Zhiyi Zhu; Kai Xu; Yuanqing He (Science China Earth Sciences, 2021)
Regionality, comprehensiveness, and complexity are regarded as the basic characteristics of geography. The exploration of their core connotations is an essential way to achieve breakthroughs in geography in the new era. This paper focuses on the important method in geographic research: Geographic modeling and simulation. First, we clarify the research requirements of the said three characteristics of geography and its potential to address geo-problems in the new era. Then, the supporting capabilities of the existing geographic modeling and simulation systems for geographic research are summarized from three perspectives: Model resources, modeling processes, and operational architecture. Finally, we discern avenues for future research of geographic modeling and simulation systems for the study of regional, comprehensive and complex characteristics of geography. Based on these analyses, we propose implementation architecture of geographic modeling and simulation systems and discuss the module composition and functional realization, which could provide theoretical and technical support for geographic modeling and simulation systems to better serve the development of geography in the new era.

Photosynthetic compensation of non-leaf organ stems of the invasive species Sphagneticola trilobata (L.) Pruski at low temperature - Min-ling Cai; Wen-qiao Ding; Jun-jie Zhai; Xiao-ting Zheng; Zheng-chao Yu; Qi-lei Zhang; Xiao-hua Lin; Wah Soon Chow; Chang-lian Peng (Photosynthesis Research, 2021)

Possible pharmaceutical applications can be developed from naturally occurring phenanthroindolizidine and phenanthroquinolizidine alkaloids - Xian-hui Jia; Huan-xin Zhao; Cheng-lin Du; Wen-zhao Tang; Xiao-jing Wang (Phytochemistry Reviews, 2021)

Transcription Factor VAX1 Regulates the Regional Specification of the Subpallium Through Repressing Gsx2 - Yan Wen; Zihao Su; Ziwu Wang; Lin Yang; Guoping Liu; Zicong Shang; Yangyang Duan; Heng Du; Zhenmeiyu Li; Yan You; Xiaosu Li; Zhengang Yang; et al. (Molecular Neurobiology, 2021)

Using stratified Bayesian model averaging in probabilistic forecasts of precipitation over the middle and lower Yangtze River region - Haixia Qi; Xiefei Zhi; Tao Peng; YongQing Bai; Chunze Lin; Wen Chen (Meteorology and Atmospheric Physics, 2021)

Overexpression of Cell-Surface Marker SLC16A1 Shortened Survival in Human High-Grade Gliomas - Hong-Han Lin; Wen-Chiuan Tsai; Chia-Kuang Tsai; Ssu-Han Chen; Li-Chun Huang; Dueng-Yuan Hueng; Kuang-Chen Hung (Journal of Molecular Neuroscience, 2021)

Advantage of Multi-Directional Stability of Spiral Clavicle Plate in Treatment of Middle One-Third Clavicle Fracture: A Finite Element Study - Dan-Kai Wu; Wen-Chuan Chen; Kun-Jhih Lin; Cheng-Lun Tsai; Kang-Ping Lin; Hung-Wen Wei (Journal of Medical and Biological Engineering, 2021)

Performance Comparison of the Deep Learning and the Human Endoscopist for Bleeding Peptic Ulcer Disease - Hsu-Heng Yen; Ping-Yu Wu; Pei-Yuan Su; Chia-Wei Yang; Yang-Yuan Chen; Mei-Fen Chen; Wen-Chen Lin; Cheng-Lun Tsai; Kang-Ping Lin (Journal of Medical and Biological Engineering, 2021)
Purpose Management of peptic ulcer bleeding is clinically challenging. Accurate characterization of the bleeding during endoscopy is key for endoscopic therapy. This study aimed to assess whether a deep learning model can aid in the classification of bleeding peptic ulcer disease. Methods Endoscopic still images of patients ( n = 1694) with peptic ulcer bleeding for the last 5 years were retrieved and reviewed. Overall, 2289 images were collected for deep learning model training, and 449 images were validated for the performance test. Two expert endoscopists classified the images into different classes based on their appearance. Four deep learning models, including Mobile Net V2, VGG16, Inception V4, and ResNet50, were proposed and pre-trained by ImageNet with the established convolutional neural network algorithm. A comparison of the endoscopists and trained deep learning model was performed to evaluate the model’s performance on a dataset of 449 testing images. Results The results first presented the performance comparisons of four deep learning models. The Mobile Net V2 presented the optimal performance of the proposal models. The Mobile Net V2 was chosen for further comparing the performance with the diagnostic results obtained by one senior and one novice endoscopists. The sensitivity and specificity were acceptable for the prediction of “normal” lesions in both 3-class and 4-class classifications. For the 3-class category, the sensitivity and specificity were 94.83% and 92.36%, respectively. For the 4-class category, the sensitivity and specificity were 95.40% and 92.70%, respectively. The interobserver agreement of the testing dataset of the model was moderate to substantial with the senior endoscopist. The accuracy of the determination of endoscopic therapy required and high-risk endoscopic therapy of the deep learning model was higher than that of the novice endoscopist. Conclusions In this study, the deep learning model performed better than inexperienced endoscopists. Further improvement of the model may aid in clinical decision-making during clinical practice, especially for trainee endoscopist.

Recycle of synthetic calcium fluoride and waste sulfuric acid to produce electronic grade hydrofluoric acid - Min-Fa Lin; Jhong-Lin Wu; Ken-Lin Chang; Wen-Jhy Lee; Chih-Ping Chang; Yung-Chang Lin; Po-Han Chen (Environmental Science and Pollution Research, 2021)

Extreme climate changes over three major river basins in China as seen in CMIP5 and CMIP6 - Xian Zhu; Shao-Yi Lee; Xiaohang Wen; Zhenming Ji; Lei Lin; Zhigang Wei; Zhiyuan Zheng; Danya Xu; Wenjie Dong (Climate Dynamics, 2021)

Influence of the QBO on tropical convection and its impact on tropical cyclone activity over the western North Pacific - Jingliang Huangfu; Yulian Tang; Tianjiao Ma; Wen Chen; Lin Wang (Climate Dynamics, 2021)

Spontaneous thought-related network connectivity predicts sertraline effect on major depressive disorder - Li-Ming Hsu; Timothy Joseph Lane; Changwei W. Wu; Chien-Yuan Lin; Chi-Bin Yeh; Hung-Wen Kao; Ching-Po Lin (Brain Imaging and Behavior, 2021)

Geographic and subsequent biotic isolations led to a diversity anomaly of section Heterotropa (genus Asarum : Aristolochiaceae) in insular versus continental regions of the Sino‐Japanese Floristic Region - Daiki Takahashi; Shota Sakaguchi; Yu Feng; Yuji Isagi; Ying‐Xiong Qiu; Pan Li; Rui‐Sen Lu; Chang‐Tse Lu; Shih‐Wen Chung; Yang‐Shan Lin; Yun‐Chao Chen; Atsushi J. Nagano; et al. (Journal of Biogeography, 2021)
Aim The Sino‐Japanese Floristic Region has extremely high species diversity with respect to temperate plants; however, the reasons for this diversity are poorly understood because most studies have only considered geographic isolation caused by climatic oscillations. In some plant groups, high floral trait diversity and uneven species diversity between insular systems and the continental area suggest other factors may have important roles too. The primary purpose of this study is to reveal how abiotic and biotic factors have shaped the species diversity anomaly of Heterotropa between the insular systems and the continental area. Location The Sino‐Japanese Floristic Region. Taxon Section Heterotropa (genus Asarum ; Aristolochiaceae). Methods Using ddRAD‐seq and chloroplast genome data, we built a time‐calibrated phylogenetic tree including 79 species. We estimated the patterns of floral traits (flowering time and floral size) evolution using macroevolutionary modelling, and tested the correlation of speciation rate with the trait evolution rates. Finally, we estimated the isolation factors of all taxa pairs and sister‐taxa pairs based on distribution range and floral traits. Results Phylogenetic analysis indicated that Heterotropa was diverged into two clades (continental clade and insular clade) in the Miocene, and the major subclades corresponded to geographic entities. Most rate shifts accelerating floral trait's evolution occurred during the Pleistocene period. Evolution rate of floral traits showed positive correlation with the speciation rate. Large proportion of taxa in the insular clade are distributed allopatrically. Several sister pairs showed floral trait divergence with geographic overlap. Main Conclusions The diversification of Heterotropa appears to have been triggered by geographic and climatic events, and subsequent repeated floral trait evolution with and without geographic isolation. Furthermore, the high species diversity in the insular systems would have been formed by the repeated range fragmentations and contractions. Our study demonstrates the importance of multidimensional studies to understand the diversification process of temperate plants in the Sino‐Japanese Floristic Region.

The developmental regulator PatD modulates assembly of the cell‐division protein FtsZ in the cyanobacterium Anabaena sp. PCC 7120 - Li Wang; Tian‐Cai Niu; Ana Valladares; Gui‐Ming Lin; Ju‐Yuan Zhang; Antonia Herrero; Wen‐Li Chen; Cheng‐Cai Zhang (Environmental Microbiology, 2021)
Summary FtsZ is a tubulin‐like GTPase that polymerizes to initiate the process of cell division in bacteria. Heterocysts are terminally differentiated cells of filamentous cyanobacteria that have lost the capacity for cell division and in which the ftsZ gene is downregulated. However, mechanisms of FtsZ regulation during heterocyst differentiation have been scarcely investigated. The patD gene is NtcA dependent and involved in the optimization of heterocyst frequency in Anabaena sp. PCC 7120. Here, we report that the inactivation of patD caused the formation of multiple FtsZ‐rings in vegetative cells, cell enlargement, and the retention of peptidoglycan synthesis activity in heterocysts, whereas its ectopic expression resulted in aberrant FtsZ polymerization and cell division. PatD interacted with FtsZ, increased FtsZ precipitation in sedimentation assays, and promoted the formation of thick straight FtsZ bundles that differ from the toroidal aggregates formed by FtsZ alone. These results suggest that in the differentiating heterocysts, PatD interferes with the assembly of FtsZ. We propose that in Anabaena FtsZ is a bifunctional protein involved in both vegetative cell division and regulation of heterocyst differentiation. In the differentiating cells PatD‐FtsZ interactions appear to set an FtsZ activity that is insufficient for cell division but optimal to foster differentiation.

Molecular mapping of quantitative disease resistance loci for soybean partial resistance to Phytophthora sansomeana - Feng Lin; Wenlong Li; Austin G. McCoy; Xuan Gao; Paul J. Collins; Na Zhang; Zixiang Wen; Sizhe Cao; Shabir H. Wani; Cuihua Gu; Martin I. Chilvers; Dechun Wang (Theoretical and Applied Genetics, 2021)

Identification of a delayed leaf greening gene from a mutation of pummelo - Hui-Wen Yu; Zhi-Hao Lu; Xia Wang; Dan Liu; Jia-Xian He; Xiao-Lin Jiang; Ling-Jun Ke; Wen-Wu Guo; Xiu-Xin Deng; Qiang Xu (Science China Life Sciences, 2021)

Design, synthesis, and antidepressant/anticonvulsant activities of 3H-benzo[f]chromen chalcone derivatives - Qiu-Wan Tan; Li-Ya He; Zhi-Wen He; Wei-Hua Liu; Shan-Shan Zhang; Lin Lin; Hong-Li Yang; Li-Ping Guan (Medicinal Chemistry Research, 2021)

Cysteiniphilum marinum sp. nov., isolated from coastal seawater - Hai-Min Luo; Jun-Hui Feng; Liang-Hui Li; Meng-Meng Li; Ru-Qin Liu; Fu Chen; Ying Lin; Wen-Jun Li; Ping-Hua Qu; Min Xiao (Antonie van Leeuwenhoek, 2021)

In-Situ Seawater Gamma Spectrometry with LaBr3 Detector at a Nuclear Power Plant Outlet - Daowei Dou; Zhi Zeng; Wen Yu; Ming Zeng; Wu Men; Feng Lin; Hao Ma; Jianping Cheng; Junli Li (Journal of Marine Science and Engineering, 2021)
In a nuclear emergency, the application of in situ spectrometers for monitoring environmental radioactivity is significantly important, as information on the type and activity of radionuclides released from the accident can be obtained quickly. However, in emergency environmental radiological monitoring, a balance between energy resolution and detecting efficiency must be considered in selecting an appropriate detector. In this study, in situ gamma spectrometry was conducted with the LaBr3 detector to determine the radioactivity of seawater at the discharging outlet of a coastal nuclear power plant in southeast China. The results show that the LaBr3 scintillator has excellent energy resolution and detection efficiency, making it a promising detector for emergency monitoring.

Detection of Vestibular Schwannoma on Triple-parametric Magnetic Resonance Images Using Convolutional Neural Networks - Tzu-Hsuan Huang; Wei-Kai Lee; Chih-Chun Wu; Cheng-Chia Lee; Chia-Feng Lu; Huai-Che Yang; Chun-Yi Lin; Wen-Yuh Chung; Po-Shan Wang; Yen-Ling Chen; Hsiu-Mei Wu; Wan-You Guo; et al. (Journal of Medical and Biological Engineering, 2021)
Purpose The first step in typical treatment of vestibular schwannoma (VS) is to localize the tumor region, which is time-consuming and subjective because it relies on repeatedly reviewing different parametric magnetic resonance (MR) images. A reliable, automatic VS detection method can streamline the process. Methods A convolutional neural network architecture, namely YOLO-v2 with a residual network as a backbone, was used to detect VS tumors from MR images. To heighten performance, T1-weighted–contrast-enhanced, T2-weighted, and T1-weighted images were combined into triple-channel images for feature learning. The triple-channel images were cropped into three sizes to serve as input images of YOLO-v2. The VS detection effectiveness levels were evaluated for two backbone residual networks that downsampled the inputs by 16 and 32. Results The results demonstrated the VS detection capability of YOLO-v2 with a residual network as a backbone model. The average precision was 0.7953 for a model with 416 × 416-pixel input images and 16 instances of downsampling, when both the thresholds of confidence score and intersection-over-union were set to 0.5. In addition, under an appropriate threshold of confidence score, a high average precision, namely 0.8171, was attained by using a model with 448 × 448-pixel input images and 16 instances of downsampling. Conclusion We demonstrated successful VS tumor detection by using a YOLO-v2 with a residual network as a backbone model on resized triple-parametric MR images. The results indicated the influence of image size, downsampling strategy, and confidence score threshold on VS tumor detection.

A survey of chloramphenicol residues in aquatic products of Shenzhen, South China - Lan Luo; Shaoyou Lu; Chengpeng Huang; Fu Wang; Yan Ren; He Cao; Qihui Lin; Zhiqiang Tan; Xiaodong Wen (Food Additives & Contaminants: Part A, 2021)

Naringin Ameliorates Haloperidol-Induced Neurotoxicity and Orofacial Dyskinesia in a Rat Model of Human Tardive Dyskinesia - Mao-Hsien Wang; Chih-Chuan Yang; Hsiang-Chien Tseng; Chih-Hsiang Fang; Yi-Wen Lin; Hung-Sheng Soung (Neurotoxicity Research, 2021)

Androgenic Sensitivities and Ovarian Gene Expression Profiles Prior to Treatment in Japanese Eel (Anguilla japonica) - Yung-Sen Huang; Wen-Chih Cheng; Chung-Yen Lin (Marine Biotechnology, 2021)

Effects of Diversified Cropping Sequences and Tillage Practices on Soil Organic Carbon, Nitrogen, and Associated Fractions in the North China Plain - Ahmad Latif Virk; Wen-Sheng Liu; Jia-Rui Niu; Cheng-Tang Xu; Qiu-Yue Liu; Zheng-Rong Kan; Xin Zhao; Hai-Lin Zhang (Journal of Soil Science and Plant Nutrition, 2021)

Five matrine-type alkaloids from Sophora tonkinensis - Qing Tang; Ding Luo; Ding-Chai Lin; Wen-Zhi Wang; Can-Jie Li; Xue-Fang Zhuo; Zhong-Nan Wu; Yu-Bo Zhang; Guo-Cai Wang; Yao-Lan Li (Journal of Natural Medicines, 2021)

Enhanced treatment of shale gas fracturing waste fluid through plant-microbial synergism - Bo Shao; Xu Tan; Ju-Long Li; Mei He; Lei Tian; Wen-Jie Chen; Yan Lin (Environmental Science and Pollution Research, 2021)

Effect of dermal phthalate levels on lung function tests in residential area near a petrochemical complex - Chih-Wen Wang; Szu-Chia Chen; Da-Wei Wu; Huang-Chi Chen; Hung-Hsun Lin; Hung Su; Jen-taie Shiea; Wen-Yi Lin; Chih-Hsing Hung; Chao-Hung Kuo (Environmental Science and Pollution Research, 2021)

Common and specific neural correlates underlying insight and ordinary problem solving - Jiabao Lin; Xue Wen; Xuan Cui; Yanhui Xiang; Jiushu Xie; Yajue Chen; Ruiwang Huang; Lei Mo (Brain Imaging and Behavior, 2021)

Brain voxel-based morphometry correlates of emotion dysregulation in attention-deficit hyperactivity disorder - Chia-Jui Tsai; Hsiang-Yuan Lin; Isaac Wen-Yih Tseng; Susan Shur-Fen Gau (Brain Imaging and Behavior, 2021)

A dye combination for the staining of pollen coat and pollen wall - Xin-Lei Jia; Jing-Shi Xue; Fang Zhang; Chi Yao; Shi-Yi Shen; Chang-Xu Sui; Yu-Jia Peng; Qin-Lin Xu; Yi-Feng Feng; Wen-Jing Hu; Ping Xu; Zhong-Nan Yang (Plant Reproduction, 2021)

Modelling plant canopy effects on water-heat exchange in the freezing-thawing processes of active layer on the Qinghai-Tibet Plateau - Lin-mao Guo; Juan Chang; Hong-liang Xu; Wen-jun Sun (Journal of Mountain Science, 2021)

Ghrelin Affects Gastric Cancer Progression by Activating AMPK Signaling Pathway - Xiao-Lin Hu; Yong-Jun Zhu; Chang-Hua Hu; Li You; Juan Wu; Xiao-Yan He; Wen-Jie Huang; Zong-Hui Wu (Biochemical Genetics, 2021)

Ring distribution patterns—diversification or speciation? Comparative phylogeography of two small mammals in the mountains surrounding the Sichuan Basin - Yanqun Wang; Anderson Feijó; Jilong Cheng; Lin Xia; Zhixin Wen; Deyan Ge; Jian Sun; Liang Lu; Song Li; Qisen Yang (Molecular Ecology, 2021)
Studying the genetic differentiation in a unique geographical area contributes to understanding the process of speciation. Here, we explore the spatial genetic structure and underlying formation mechanism of two congeneric small mammal species ( Apodemus draco and A. chevrieri ), which are mainly distributed in the mountains surrounding the lowland Sichuan Basin, southwest China. We applied a set of comparative phylogeographical analyses to determine their genetic diversification patterns, combining mitochondrial ( Cytb and COI ) and nuclear (microsatellite loci) markers, with dense sampling throughout the range (411 A . draco from 21 sites and 191 A . chevrieri from 22 sites). Moreover, we performed three complementary statistical methods to investigate the correlation between genotype and geographical and environmental components, and predicted the potential suitable distributional range under the present and historical climate conditions. Our results suggest that both species have experienced allopatric differentiation and admixture in historical periods, resulting in a ring‐shape diversification, under the barrier effect of the Sichuan Basin. We infer that the tectonic events of the Qinghai–Tibetan Plateau and climatic oscillations during the Quaternary played an important role on the genetic divergence of the two species by providing environmental heterogeneity and geographical variation. Our study reveals a case of two sympatric small mammals following a ring‐shaped diversification pattern and provides insight into the process of differentiation.

Cytotoxic p -terphenyls from the deep-sea-derived Aspergillus candidus - Yu-Kun Lin; Chun-Lan Xie; Cui-Ping Xing; Bao-Qu Wang; Xiao-Xue Tian; Jin-Mei Xia; Ling-Yun Jia; Ying-Ni Pan; Xian-Wen Yang (Natural Product Research, 2021)

Cytotoxic meroterpenoids from the marine sponge Dactylospongia elegans - Hao-Bing Yu; Zi-Fei Yin; Bin-Bin Gu; Jian-Peng Zhang; Shu-Ping Wang; Fan Yang; Hou-Wen Lin (Natural Product Research, 2021)

Effects of Sediment Characteristics on Carbon Dioxide Fluxes Based on Interacting Factors in Unvegetated Tidal Flats - Wei-Jen Lin; Ming-Chih Chiu; Chiao-Wen Lin; Hsing-Juh Lin (Frontiers in Marine Science, 2021)
The contribution of unvegetated tidal flats to global net primary production is comparable to that of some vegetated coastal habitats. However, compared to carbon flux regulating factors in vegetated habitats, those in unvegetated tidal flats are not well understood, particularly in terms of their cause-effect relationships. Maximum gross primary production (GPP m ), net primary production (NPP) and total respiration (TR) during emersion at noon when the irradiance level was at the saturation level for photosynthesis in nine unvegetated tidal flats across the Taiwan Strait in tropical and subtropical regions were determined in winter and summer from 2011 to 2016 to examine the direct and indirect relationships between sediment characteristics and carbon fluxes by using structural equation models (SEM). Most of the GPP m and NPP values were higher in winter than in summer. Conversely, the TR values were higher in summer than in winter. The NPP values at some sites shifted to negative values in summer, indicating the sites were carbon sources. The values of GPP m , TR and NPP for the tidal flats all increased significantly with increasing sediment mud content. The SEM results showed that the sediment mud content directly increased GPP m or indirectly increased GPP m via a compositional shift in benthic microalgae. The sediment mud content also directly increased TR or indirectly increased TR via increased organic matter content. The contribution of benthic microalgal and macrofaunal biomass to TR was relatively minor. This result suggests that primary production was stimulated mainly by the organic matter content rather than by increased microalgal biomass. With the integrated SEM framework, our results showed mechanistic evidence of how sediment mud content acted as a critical factor regulating carbon fluxes in unvegetated tidal flats.

QTL mapping of the genetic basis of stem diameter in soybean - Chong-Yuan Sun; Yu-Ming Yang; Lin Jia; Xiao-Qian Liu; Huan-Qing Xu; Hai-Yan Lv; Zhong-Wen Huang; Dan Zhang (Planta, 2021)

Experiments on granular flow behavior and deposit characteristics: implications for rock avalanche kinematics - Kun Li; Yu-Feng Wang; Qi-Wen Lin; Qian-Gong Cheng; Yue Wu (Landslides, 2021)

First report of cucurbit chlorotic yellows virus infecting melon, watermelon and wild melon in the Philippines - Hsin-Yi Chang; Li-Cheng Chen; Chung-Cheng Lin; Wen-Shi Tsai (Journal of Plant Pathology, 2021)

Stress-induced phosphoprotein 1 facilitates breast cancer cell progression and indicates poor prognosis for breast cancer patients - Lizhi Lin; Jialiang Wen; Bangyi Lin; Erjie Xia; Chen Zheng; Lechi Ye; Yinghao Wang; Ouchen Wang; Yizuo Chen (Human Cell, 2021)

Targeted deletion of HAI-1 increases prostasin proteolysis but decreases matriptase proteolysis in human keratinocytes - Dajun D. Lu; Yayun Gu; Sheng-Wen A. Li; Robert J. Barndt; Shih-Ming Huang; Jehng-Kang Wang; Hui Chen Su; Michael D. Johnson; Chen-Yong Lin (Human Cell, 2021)

Sandbox modelling of interactions of landslide deposits with terrace sediments aided by field observation - Wen-Chieh Cheng; Zhao Duan; Zhong-Fei Xue; Lin Wang (Bulletin of Engineering Geology and the Environment, 2021)

Cryostructures and ground ice content in ice-rich permafrost area of the Qinghai-Tibet Plateau with Computed Tomography Scanning - Xing-wen Fan; Zhan-ju Lin; Ze-yong Gao; Xiang-lian Meng; Fu-jun Niu; Jing Luo; Guo-an Yin; Fu-jun Zhou; Ai-yu Lan (Journal of Mountain Science, 2021)

The Effects of Installation on the Elastic Stiffness Coefficients of Spudcan Foundations - Wen-Long Lin; Zhen Wang; Fei Liu; Jiang-Tao Yi (Journal of Marine Science and Engineering, 2021)
Subjected to pre-load, spudcan foundations, widely utilized to support offshore jack-up rigs, may penetrate in a few diameters into soft clays before mobilizing sufficient resistance from soil. While its stress–strain behavior is known to be affected by the embedment condition and soil backflow, the small-strain calculation with wished-in-place assumption was previously adopted to analyze its elastic stiffness coefficients. This study takes advantage of a recently developed dual-stage Eulerian–Lagrangian (DSEL) technique to re-evaluate the elastic stiffness coefficients of spudcans after realistically modelling the deep, continuous spudcan penetration. A numerical parametric exercise is conducted to investigate the effects of strength non-homogeneity, embedment depths, and the spudcan’s size on the elastic stiffness. On these bases, an expression is provided such that the practicing engineers can conveniently factor the installation effects into the estimation of elastic stiffness coefficients of spudcans.

Rosanortriterpenes A–B, two new nortriterpenes from the fruits of Rosa laevigata var. leiocapus - Yu-Nong Tian; Bai-Lin Li; Juan-Juan Hu; Jin-Dan Xie; Wen-Jing Xiao; Ling-Hui Nie; Jie-Wei Wu (Natural Product Research, 2021)

Simvastatin Enhances Muscle Regeneration Through Autophagic Defect-Mediated Inflammation and mTOR Activation in G93ASOD1 Mice - Yafei Wang; Lin Bai; Shuai Li; Ya Wen; Qi Liu; Rui Li; Yaling Liu (Molecular Neurobiology, 2021)

Restraint of Bagging on Fruit Skin Coloration in on-Tree Kiwifruit (Actinidia arguta) - Yukuo Li; Xiujuan Qi; Wen Cui; Miaomiao Lin; Chengkui Qiao; Yunpeng Zhong; Jinbao Fang; Chungen Hu (Journal of Plant Growth Regulation, 2021)

Identification and characterization of CONSTANS-like genes from Curcuma alismatifolia - Yuan-Yuan Li; Xiao-Huang Chen; Hui-Wen Yu; Qi-Lin Tian; Luan-Mei Lu (Horticulture, Environment, and Biotechnology, 2021)

Molecular cloning and functional characterization of the hypoxia-inducible factor-1α in bighead carp (Aristichthys nobilis) - Yan Lin; Ling-Hong Miao; Bo Liu; Bing-Wen Xi; Liang-Kun Pan; Xian-Ping Ge (Fish Physiology and Biochemistry, 2021)

Increased depression risk for elderly women with high blood levels of strontium and barium - Jia Lv; Yan-ling Li; Wen-qiang Ren; Rong Li; Jian-rong Chen; Chao Bao; Zhi-ping Du; Shun Feng; Ling Gu; Hui Gao; Kai-yong Liu; Lin-sheng Yang; et al. (Environmental Chemistry Letters, 2021)

Experimental study on the mechanical and permeability behaviors of limestone under hydro-mechanical-coupled conditions - Zhenjie Zhang; Qiangyong Zhang; Kang Duan; MingYang Ren; Xiangjie Yin; Hanxiang Lin; Wen Xiang (Bulletin of Engineering Geology and the Environment, 2021)

Increased resting state functional irregularity of T2DM brains with high HbA1c: sign for impaired verbal memory function? - Xin Zhang; Ying Yu; Zhe-Sheng Shi; Ke Xu; Jia-Hao Feng; Ze-Yang Li; Xiang-Nan Zhang; Shu-Ning Shen; Yang Yang; Lin-Feng Yan; Jin Zhang; Qian Sun; et al. (Brain Imaging and Behavior, 2021)

Carbon isotope variations of modern soils in the eastern margin of the Tibetan Plateau and their controlling factors - Lin Qi; Yan-song Qiao; Zong-xiu Liu; Sha-sha Peng; Yu Cheng; Yan Wang; Xu-jiao Zhang; Ming-zhong Tian; Shuai-bin Yang; Wen-bin Bai (Journal of Mountain Science, 2021)

Improving long-baseline rapid GPS time transfers by a modified common-view method - Wen-Hung Tseng; Shinn-Yan Lin (GPS Solutions, 2021)

The molecular mechanism of a novel derivative of BTO-956 induced apoptosis in human myelomonocytic lymphoma cells - Yu-Lin Li; De-Jun Zhou; Zheng-Guo Cui; Lu Sun; Qian-Wen Feng; Shahbaz Ahmad Zakki; Yusuke Hiraku; Cheng-Ai Wu; Hidekuni Inadera (Apoptosis, 2021)

The Effect of Wave-Induced Current and Coastal Structure on Sediment Transport at the Zengwen River Mouth - Chun-Hung Pao; Jia-Lin Chen; Shih-Feng Su; Yu-Ching Huang; Wen-Hsin Huang; Chien-Hung Kuo (Journal of Marine Science and Engineering, 2021)
The mechanisms that control estuarine sediment transport are complicated due to the interaction between riverine flows, tidal currents, waves, and wave-driven currents. In the past decade, severe seabed erosion and shoreline retreat along the sandy coast of western Taiwan have raised concerns regarding the sustainability of coastal structures. In this study, ADCPs (Acoustic Doppler Current Profiler) and turbidity meters were deployed at the mouth of the Zengwen river to obtain the time series and the spatial distribution of flow velocities and turbidity during the base flow and flood conditions. A nearshore circulation model, SHORECIRC, has been adapted into a hybrid finite-difference/finite-volume, TVD (Total Variation Diminishing)-type scheme and coupled with the wave-spectrum model Simulating Waves Nearshore (SWAN). Conventional finite-difference schemes often produce unphysical oscillations when modeling coastal processes with abrupt bathymetric changes at river mouths. In contrast, the TVD-type finite volume scheme allows for robust treatment of discontinuities through the shock-capturing mechanism. The model reproduces water levels, waves, currents observed at the mouth of the Zengwen River reasonably well. The simulated residual sediment transport patterns demonstrate that the transport process at the river mouth is dominated by the interaction of the bathymetry and wave-induced currents when the riverine discharge was kept in reservoirs. The offshore residual transport causes erosion at the northern part of the river mouth, and the onshore residual transport causes accretion in the ebb tidal shoals around the center of the river mouth. The simulated morphological evolution displays significant changes on shallower deltas. The location with significant sea bed changes is consistent with the spot in which severe erosion occurred in recent years. Further analysis of morphological evolution is also discussed to identify the role of coastal structures, for example, the extension of the newly constructed groins near the river mouth.

Microbiome Reengineering by Heat Selection for Rapid Biodegradation of Trichloroethylene with Minimal Vinyl Chloride Formation - Ai-Lin Chan; Chien-Yun Tseng; Tzu-Wen Chen; Yi-Hsuan Lo; Shu-Chi Chang (Water, Air, & Soil Pollution, 2021)

Effect of replacing inorganic trace minerals at lower organic levels on growth performance, blood parameters, antioxidant status, immune indexes, and fecal mineral excretion in weaned piglets - Wen-Fei Zhang; Min Tian; Jun-Shuai Song; Fang Chen; Gang Lin; Shi-Hai Zhang; Wu-Tai Guan (Tropical Animal Health and Production, 2021)

Simulation of the fragmentation and propagation of jointed rock masses in rockslides: DEM modeling and physical experimental verification - Qi-wen Lin; Qian-Gong Cheng; Yu Xie; Feng-shou Zhang; Kun Li; Yu-feng Wang; Yuan-yuan Zhou (Landslides, 2021)

Sexual communication in diurnal moths: behaviors and mechanisms - Lian Chen; Xiao-Yun Wang; Wen Lu; Xia-Lin Zheng (International Journal of Tropical Insect Science, 2021)

Syndecan-3 contributes to the regulation of the microenvironment at the node of Ranvier following end-to‑side neurorrhaphy: sodium image analysis - Chiung-Hui Liu; Yu-Chen Kuo; Che-Yu Wang; Chao-Chun Hsu; Ying-Jui Ho; Yun-Chi Chiang; Fu-Der Mai; Wei-Jhih Lin; Wen-Chieh Liao (Histochemistry and Cell Biology, 2021)

Delayed association of acute particulate matter 2.5 air pollution exposure with loss of complexity in cardiac rhythm dynamics: insight from detrended fluctuation analysis - Tsung-Ying Tsai; Li-Wei Lo; Shin-Huei Liu; Wen-Han Cheng; Yu-Hui Chou; Wei-Lun Lin; Yenn-Jiang Lin; Shih-Lin Chang; Yu-Feng Hu; Fa-Po Chung; Jo-Nan Liao; Tze-Fan Chao; et al. (Environmental Science and Pollution Research, 2021)

The regional difference in engineering-control and tillage factors of Chinese Soil Loss Equation - Rui-yin Chen; Dong-chun Yan; An-bang Wen; Zhong-lin Shi; Jia-cun Chen; Yuan Liu; Tai-li Chen (Journal of Mountain Science, 2021)

Varying support for abundance‐centre and congeneric‐competition hypotheses along elevational transects of mammals - Zhixin Wen; Deyan Ge; Anderson Feijó; Yuanbao Du; Jilong Cheng; Jian Sun; Yanqun Wang; Lin Xia; Qisen Yang (Journal of Biogeography, 2021)
Aim Whether species are most abundant at their geographic range centre and increasingly rare towards range limits (the abundance‐centre hypothesis, ACH) has weak empirical support in birds along elevational gradients. This may be due to empirical limitations—most studies do not capture the multi‐faceted nature of elevational gradients or species interactions. We examine the ACH and an alternative that the abundance maximum of elevational sympatric congeners will occur at different elevations along a gradient (the congeneric‐competition hypothesis, CCH). Location Twelve elevational gradients in Central and Southwest China. Taxon Five small mammal species, including three congeneric species. Methods The ACH was tested by fitting abundance patterns to Huisman‐Olff‐Fresco (HOF) models and measuring the relative elevational distance between a species' abundance‐weighted range centre ( RC Abu ) and its elevational range centre. The CCH was tested by calculating the elevational overlap value of each congeneric pair and the relative elevational distance ( RC AbuDiff ) between the RC Abu s of congeners. Results Abundances of each species showed diverse patterns along different gradients. For all species, a unimodal symmetric pattern appeared at most once among the studied gradients and found in only four (8.7%) of the total cases. Most (90.9%) of the Apodemus congeneric pairs had a high elevational overlap (above 75%). For each of the three congeneric pairs, 40.0% to 50.0% of the cases showed RC AbuDiff values > 0.25, suggesting that the congeners’ RC Abu s were separated by at least one elevational climate zone. Main conclusions Species' elevational abundance patterns may vary among different elevational gradients in the same geographic region. The elevational abundance patterns of five mammalian species were rarely consistent with the ACH after the spatial variability of the patterns was considered. The abundance patterns of congeneric species showed moderate support for the CCH.

Decline of Seriatopora (Scleractinia: Pocilloporidae) fecundity in Taiwan in 2018–2019 - Luca Cirino; Sujune Tsai; Fu-Wen Kuo; Zhi-Hong Wen; Pei-Jie Meng; Chiahsin Lin (Marine Biology Research, 2021)

Small RNA Sequencing Analysis of Germinating Single-bud Seedcane Sett in Sugarcane - Kai-Chao Wu; Lin Xu; Zhi-Nian Deng; Tian Pang; Rong-Hua Zhang; Yi-Jie Li; Xiao-Yan Liu; Cheng-Feng Huang; Wen-Xian Qin; Jian-Feng Wei; Li-Ping Wei; Yang-Rui Li; et al. (Sugar Tech, 2021)

The adaptability of typical precipitation ensemble prediction systems in the Huaihe River basin, China - Han Wang; Ping-an Zhong; Fei-lin Zhu; Qing-wen Lu; Yu-fei Ma; Sun-yu Xu (Stochastic Environmental Research and Risk Assessment, 2021)

Changes in arthropod community but not plant quality benefit a specialist herbivore on plants under reduced water availability - Po-An Lin; Chia-Ming Liu; Jia-Ang Ou; Cheng-Han Sun; Wen-Po Chuang; Chuan-Kai Ho; Natsuko Kinoshita; Gary W. Felton (Oecologia, 2021)

First report of natural infection of tomato by pepper mild mottle virus in China - Wen Peng Zhou; Yue Yue Li; Fan Li; Guan Lin Tan (Journal of Plant Pathology, 2021)

Reliability and Validity of a Mobile Device for Assessing Head Control Ability - Mohammad Nikkhoo; Chi-Chien Niu; Chen-Ju Fu; Meng-Ling Lu; Wen-Chien Chen; Yang-Hua Lin; Chih-Hsiu Cheng (Journal of Medical and Biological Engineering, 2021)

Direct Calculation Method for the Analysis of Non-linear Behavior of Ground-Support Interaction of a Circular Tunnel Using Convergence Confinement Approach - Yu-Lin Lee; Wen-Kuei Hsu; Chi-Min Lee; Yi-Xian Xin; Bo-Yu Zhou (Geotechnical and Geological Engineering, 2021)

Simultaneously decreased temporal variability and enhanced variability-strength coupling of emotional network connectivities are related to positive symptoms in patients with schizophrenia - Yanjia Deng; Shuguang Han; Dongliang Cheng; Hui Li; Bin Zhang; Youyong Kong; Yong Lin; Yingjia Li; Ge Wen; Kai Liu (Brain Imaging and Behavior, 2021)

Modeling motor task activation from resting-state fMRI using machine learning in individual subjects - Chen Niu; Alexander D. Cohen; Xin Wen; Ziyi Chen; Pan Lin; Xin Liu; Bjoern H. Menze; Benedikt Wiestler; Yang Wang; Ming Zhang (Brain Imaging and Behavior, 2021)

Soil anti-scourability enhanced by herbaceous species roots in a reservoir water level fluctuation zone - Wen-xiu Xu; Ling Yang; Yu-hai Bao; Jin-lin Li; Jie Wei (Journal of Mountain Science, 2021)

Dapagliflozin suppresses ER stress and protects doxorubicin-induced cardiotoxicity in breast cancer patients - Wei-Ting Chang; Yu-Wen Lin; Chung-Han Ho; Zhih-Cherng Chen; Ping-Yen Liu; Jhih-Yuan Shih (Archives of Toxicology, 2021)

Community structure of bacterioplankton and its relationship with environmental factors in the upper reaches of the Heihe River in Qinghai Plateau - Zhang Qian‐Qian; Jian Sheng‐Long; Li Ke‐Mao; Wu Zhen‐Bing; Guan Hong‐Tao; Hao Jin‐Wen; Wang Shu‐Yi; Lin Yao‐Yao; Wang Guo‐Jie; Li Ai‐Hua (Environmental Microbiology, 2021)
Summary Planktonic microorganisms play a key role in the biogeochemical processes of the aquatic system, and they may be affected by many factors. High‐throughput sequencing technology was used in this study to investigate and study the bacterioplankton community of water bodies in the upper reaches of the Heihe River Basin in Qinghai Plateau. Results showed that Proteobacteria, Firmicutes, Bacteroidetes and Actinobacteria are the predominant phyla in this river section, while the main genera are Thiomonas , Acidibacillus , Acidocella , Rhodanobacter , Acidithiobacter and Gallionella , which are autochthonous in the acid‐mine drainage. Additionally, total nitrogen, total phosphorus, permanganate index and pH are significantly correlated with the bacterioplankton abundance and are the main limiting factors for the spatial distribution of the bacterioplankton. PICRUSt inferred that the mainstream microbial assemblages had a higher abundance of KOs belong to metabolism of terpenoids and polyketides, while the tributary had higher abundance of KOs belong to the immune system. The relationship between bacterioplankton community composition and environmental factors in the Heihe River basin was discussed for the first time in this study, which provides a theoretical basis for the healthy, orderly development of the water environment in the Heihe River Basin.

Syn-2, 3-diols and anti-inflammatory indole derivatives from Streptomyces sp. CB09001 - Lin Jiang; Hong Pu; Xiangjing Qin; Jianxin Liu; Zhongqing Wen; Yimin Huang; Jingxi Xiang; Yunxi Xiang; Jianhua Ju; Yanwen Duan; Yong Huang (Natural Product Research, 2021)

Chronic Oral Administration of Magnesium-L-Threonate Prevents Oxaliplatin-Induced Memory and Emotional Deficits by Normalization of TNF-α/NF-κB Signaling in Rats - Xin Zhou; Zhuo Huang; Jun Zhang; Jia-Liang Chen; Pei-Wen Yao; Chun-Lin Mai; Jie-Zhen Mai; Hui Zhang; Xian-Guo Liu (Neuroscience Bulletin, 2021)

Astrocyte-Derived Lactate Modulates the Passive Coping Response to Behavioral Challenge in Male Mice - Ya-Nan Yin; Jian Hu; Yi-Li Wei; Ze-Lin Li; Zhou-Cai Luo; Rui-Qi Wang; Ke-Xin Yang; Shu-Ji Li; Xiao-Wen Li; Jian-Ming Yang; Tian-Ming Gao (Neuroscience Bulletin, 2021)

Three pleiotropic loci associated with bone mineral density and lean body mass - Yu-Xue Zhang; Shan-Shan Zhang; Shu Ran; Yu Liu; Hong Zhang; Xiao-Lin Yang; Rong Hai; Hui Shen; Qing Tian; Hong-Wen Deng; Lei Zhang; Yu-Fang Pei (Molecular Genetics and Genomics, 2021)

Different effects of canopy and understory nitrogen addition on soil organic carbon and its related processes in a subtropical forest - Xiaofei Lu; Wendan Ren; Enqing Hou; Songbo Tang; Lingling Zhang; Zhanfeng Liu; Yongbiao Lin; Shenglei Fu; Dazhi Wen; Yuanwen Kuang (Journal of Soils and Sediments, 2021)

Improved control of Frankliniella occidentalis on greenhouse pepper through the integration of Orius sauteri and neonicotinoid insecticides - Qing-cai Lin; Hao Chen; Dirk Babendreier; Jin-ping Zhang; Feng Zhang; Xiao-yan Dai; Zuo-wen Sun; Zhao-peng Shi; Xiao-lin Dong; Guang-an Wu; Yi Yu; Li Zheng; et al. (Journal of Pest Science, 2021)

Facile Microwave-Assisted Synthesis of Functionalized Carbon Nitride Quantum Dots as Fluorescence Probe for Fast and Highly Selective Detection of 2,4,6-Trinitrophenol - Shikong Lu; Meihua Xue; Aojia Tao; Yuhui Weng; Bixia Yao; Wen Weng; Xiuchun Lin (Journal of Fluorescence, 2021)

TDM-guided medication of polymyxin B in a patient with CRKP-induced bloodstream infection: a case report - Xuben Yu; Jingye Pan; Ziye Zhou; Xin Wen; Ying Dai; Guanyang Lin; Zheng Jiao; Chunhong Zhang (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Phase transition pathway of hydrothermal zeolite synthesis - Ting-Lin Wu; Yen-Hua Chen; Wen-Dung Hsu (Physics and Chemistry of Minerals, 2021)

Multifractal characteristics and spatial variability of soil particle-size distribution in different land use patterns in a small catchment of the Three Gorges Reservoir Region, China - Tai-li Chen; Zhong-lin Shi; An-bang Wen; Dong-chun Yan; Jin Guo; Jia-cun Chen; Yuan Liu; Rui-yin Chen (Journal of Mountain Science, 2021)

Impact of the March Arctic Oscillation on the South China Sea summer monsoon onset - Peng Hu; Wen Chen; Shangfeng Chen; Yuyun Liu; Lin Wang; Ruping Huang (International Journal of Climatology, 2021)
This study reveals that the South China Sea summer monsoon (SCSSM) onset is closely linked to the preceding March Arctic oscillation (AO), the dominant mode of atmospheric circulation over extratropical Northern Hemisphere. The physical processes for the impact of the March AO on the SCSSM onset are further examined. March AO leads to an anomalous low‐level cyclone over subtropical western North Pacific (WNP) via eddy–mean flow interaction. The southwesterly wind anomalies to the southeastern side of the anomalous cyclone weaken the climatological trade winds, which contribute to warm sea surface temperature (SST) anomalies over tropical western‐central North Pacific via reduction of surface evaporation and latent heat flux. These warm SST anomalies excite an atmospheric Rossby wave response and reinforce the anomalous cyclone over the subtropical WNP. Via the above positive atmosphere–ocean interaction, the anomalous cyclone induced by the March AO could persist through the whole spring and shift equatorward. This anomalous cyclone creates favourable environment for the SCSSM onset via weakening the WNP subtropical high and is conducive to the transition of the low‐level zonal wind. Further analysis indicates that the March AO‐SCSSM onset relationship is independent of El Niño‐Southern Oscillation (ENSO). This result suggests that, besides the dominant tropical system (i.e., ENSO), interannual variation of the SCSSM onset also has a close relation with the dominant extratropical atmospheric system (i.e., AO), which may provide additional source for the seasonal prediction of the monsoon onset.

Angle-Based Contact Detection in Discontinuous Deformation Analysis - Hong Zhang; Jing-wen Zhang; Wei Wu; Xi Wang; Hehua Zhu; Jeen-shang Lin; Jian-gang Chen (Rock Mechanics and Rock Engineering, 2020)

AMPK Ameliorates Tau Acetylation and Memory Impairment Through Sirt1 - Lin Wang; Fang-Xiao Shi; Na Li; Yun Cao; Ying Lei; Jian-Zhi Wang; Qing Tian; Xin-Wen Zhou (Molecular Neurobiology, 2020)

Initiation mechanism of the Baige landslide on the upper reaches of the Jinsha River, China - Shi-lin Zhang; Yue-ping Yin; Xie-wen Hu; Wen-pei Wang; Sai-nan Zhu; Nan Zhang; Shui-he Cao (Landslides, 2020)