ZIF-8-derived Cu, N co-doped carbon as a bifunctional cathode catalyst for enhanced performance of microbial fuel cell - Bi-Lin Lai; Hui-Xu Wei; Zi-Nuo Luo; Tong Zheng; Yi-Hui Lin; Zhao-Qing Liu; Nan Li (Science of The Total Environment, 2023)

Comparative pulmonary toxicity assessment of tungsten trioxide and tungsten trioxide hydrate nanoparticles - Hsin Her Yu; Yi-Chun Chen; Han-Pang Su; Liliang Chen; Hung-Hsiang Chen; Kun-Yi Andrew Lin; Chia-Hua Lin (Science of The Total Environment, 2023)

Improving the estimation of canopy structure using spectral invariants: Theoretical basis and validation - Yi Lin; Siyuan Liu; Lei Yan; Kai Yan; Yelu Zeng; Bin Yang (Remote Sensing of Environment, 2023)

Corrigendum to “Comparative efficacy of omega-3 polyunsaturated fatty acids on major cardiovascular events: A network meta-analysis of randomized controlled trials” [Progress in Lipid Research. 2022 Oct 28;88:101196. doi: 10.1016/j.plipres.2022.101196] - Bo Yang; Ping-Tao Tseng; Xiang Hu; Bing-Yan Zeng; Jane Pei-Chen Chang; Yang Liu; Wei-Jie Chu; Shuang-Shuang Zhang; Zhi-Liang Zhou; Chih-Sheng Chu; Cheng-Ho Chang; Yu-Kang Tu; et al. (Progress in Lipid Research, 2023)

Origin traceability of bottled mineral water imported into China using chemical and stable isotope fingerprints - Hao Wu; Haiquan Chen; Bingqing Yi; Karyne M. Rogers; Xuehai Bian; Ni Lin; Xiuwen Zhou; Baohui Jin; Zhi Yan; Haichao Zhou (Journal of Hydrology, 2023)

Efficient preparation of red mud-based geopolymer microspheres (RM@GMs) and adsorption of fluoride ions in wastewater - Min Yi; Kaituo Wang; Hongyang Wei; Deshuai Wei; Xuefei Wei; Binghu Wei; Lin Shao; Toyohisa Fujita; Xuemin Cui (Journal of Hazardous Materials, 2023)

Continuous inactivation of human adenoviruses in water by a novel g-C3N4/WO3/biochar memory photocatalyst under light-dark cycles - Chi Zhang; Wei Xiong; Yi Li; Li Lin; Xinyi Zhou; Xinyan Xiong (Journal of Hazardous Materials, 2023)

Glioma is associated with exposure to legacy and alternative per- and polyfluoroalkyl substances - Meng-Yi Xie; Xiang-Fei Sun; Chen-Chou Wu; Guang-Long Huang; Po Wang; Zhi-Ying Lin; Ya-Wei Liu; Liang-Ying Liu; Eddy Y. Zeng (Journal of Hazardous Materials, 2023)

Hydrological connectivity affects nitrogen migration and retention in the land‒river continuum - Yao Wang; Jingjie Lin; Fenfang Wang; Qing Tian; Yi Zheng; Nengwang Chen (Journal of Environmental Management, 2023)

Assessment of algae and greenhouse gases in different reservoirs worldwide by reactor model - Yi-Xuan Li; Kai-Kai Deng; Shu-Qing Zhang; Gui-Jiao Lin; Fang Fang; Jin-Song Guo (Journal of Cleaner Production, 2023)

Impact of contractual governance and guanxi on contractors’ environmental behaviors: The mediating role of trust - Yi-Hsin Lin; Huijin Zhang (Journal of Cleaner Production, 2023)

Impacts of hydraulic conditions on microplastics biofilm development, shear stresses distribution, and microbial community structures in drinking water distribution pipes - Xiao Chen; Xiao-ying Lian; Yi Wang; Sheng Chen; Yi-ran Sun; Guo-lin Tao; Qiao-wen Tan; Jing-chun Feng (Journal of Environmental Management, 2023)

Online evaluation of catalytic co-pyrolysis of hemicellulose and polypropylene over CaO catalyst - Junjie Weng; Zhanjun Cheng; Yi Zhang; Chao Jiang; Lin Long; Jian Wang; Jianfeng Pan (Fuel, 2023)

Enhancement of lycopene bioaccessibility in tomatoes using excipient emulsions: Effect of dark tea polysaccharides - Chao Wang; Yinxin Fu; Yi Cao; Jialu Huang; Hongyi Lin; Peiyi Shen; David Julian McClements; Lingyu Han; Tiantian Zhao; Xiaoxuan Yan; Qian Li (Food Research International, 2023)

Statistical optimization of hydrogen production from bio-methanol steam reforming over Ni-Cu/Al2O3 catalysts - Yi-Kai Chih; Wei-Hsin Chen; Siming You; Chun-Han Hsu; Hong-Ping Lin; Salman Raza Naqvi; Veeramuthu Ashokkumar (Fuel, 2023)

Insight into the molecular-level details of αs1 casein interactions with IgG: Combining with LC-MS/MS and molecular modelling techniques - Jianhua Zeng; Kai Lin; Xiaoqian Zhang; Junzhe Zou; Lanwei Zhang; Pimin Gong; Jinlong Zhao; Chunhua Han; Yuhai Liu; Huaxi Yi; Tongjie Liu (Food Chemistry, 2023)

Improving probiotic (Lactobacillus casei) viability by encapsulation in alginate-based microgels: Impact of polymeric and colloidal fillers - Qian Li; Hongyi Lin; Jing Li; Lu Liu; Jialu Huang; Yi Cao; Tiantian Zhao; David Julian McClements; Jun Chen; Chengmei Liu; Jiyan Liu; Peiyi Shen; et al. (Food Hydrocolloids, 2023)

A low-cost eco-friendly fast drug extraction (FaDEx) technique for environmental and bio-monitoring of psychoactive drug in urban water and sports-persons’ urine samples - Swapnil Gurrani; Karthikeyan Prakasham; Jess Lim Zii Ying; Jentaie Shiea; Yi-Jia Ku; Yu-Chia Lin; Po-Chin Huang; Gangadhar Andaluri; Kung-Che Lee; Vinoth Kumar Ponnusamy (Environmental Research, 2023)

Novel fast pesticides extraction (FaPEx) strategy coupled with UHPLC-MS/MS for rapid monitoring of emerging pollutant fipronil and its metabolite in food and environmental samples - Raghavendra Rao Pasupuleti; Yi-Jia Ku; Tseng-Yu Tsai; Hung-Ta Hua; Yu-Chia Lin; Jentaie Shiea; Po-Chin Huang; Gangadhar Andaluri; Vinoth Kumar Ponnusamy (Environmental Research, 2023)

Role of chicken fat waste and hydrogen energy ratio as the potential alternate fuel with nano-additives: Insights into resources and atmospheric remediation process - Lin Yi-Chia; Manigandan Sekar; Arunachalam Chinnathambi; Omaima Nasif; Beata Gavurová; G.K. Jhanani; Kathirvel Brindhadevi; Nguyen Thuy Lan Chi (Environmental Research, 2023)

Effects of physiologic activities of plankton on CO2 flux in the Three Gorges Reservoir after rainfall during algal blooms - Yi-Xuan Li; Kai-Kai Deng; Gui-Jiao Lin; Bin Chen; Fang Fang; Jin-Song Guo (Environmental Research, 2023)

The associations of particulate matter short-term exposure and serum lipids are modified by vitamin D status: A panel study of young healthy adults - Jia-Min Li; Han-Yu Yang; Si-Han Wu; Shyamali C. Dharmage; Bin Jalaludin; Luke D. Knibbs; Michael S. Bloom; Yuming Guo; Lidia Morawska; Joachim Heinrich; Yim Steve Hung Lam; Li-Zi Lin; et al. (Environmental Pollution, 2023)

Association between long-term ambient ozone exposure and attention-deficit/hyperactivity disorder symptoms among Chinese children - Peien Zhou; Wangjian Zhang; Yu-Jie Xu; Ru-Qing Liu; Zhengmin Qian; Stephen Edward McMillin; Elizabeth Bingheim; Li-Zi Lin; Xiao-Wen Zeng; Bo-Yi Yang; Li-Wen Hu; Wen Chen; et al. (Environmental Research, 2023)

Spatial and seasonal variations in the carbon and lead isotopes of PM2.5 in air of residential buildings and their applications for source identification - Chien-Cheng Jung; Yang-Hsueh Chen; Charles C.-K. Chou; Yi-Tang Huang; Kuan-Ting Lin (Environmental Pollution, 2023)

Identification of serum metabolic signatures of environmental-leveled phthalate in the Taiwanese child population using NMR-based metabolomics - Sheng-Han Lee; Zhi-Yi Du; Wei-Chen Tseng; Wan-Yu Lin; Mei-Huei Chen; Ching-Chun Lin; Hao-Jan Liang; Hui-Ju Wen; Yue-Leon Guo; Pau-Chung Chen; Ching-Yu Lin (Environmental Pollution, 2023)

Distribution of antibiotic resistance genes in the sediments of Erhai Lake, Yunnan-Kweichow Plateau, China: Their linear relations with nonpoint source pollution discharges from 26 tributaries - Xiong Pan; Zeyu Chen; Wenliang Zhai; Lei Dong; Li Lin; Yi Li; Yuyi Yang (Environmental Pollution, 2023)

Estimating small structural motions from multi-view video measurement - Enjian Cai; Yi Zhang; Xiaodong Ji; Xinzheng Lu; Linlin Xie; Yuncheng Zhuang; Taisen Zhao; Guangwei Lin (Engineering Structures, 2023)

Adobe bricks as zero-material-cost solar evaporators for water-scarce regions - Andrew Caratenuto; Lijia Xie; Lin Gu; Yanpei Tian; Xiaojie Liu; Changyu Wang; Ming Su; Yi Zheng (Desalination, 2023)

Three-dimensional porous hydrogel based on hyperbranched polyethyleneimine functionalized apple pomace derived cellulose for efficient removal of methyl orange - Jifan Zhang; Yuxi Li; Yuqing Dai; Tao Lin; Haojian Shao; Yi Liu; Xunyong Liu (Chemical Engineering Journal, 2023)

Free-standing vertically aligned tin disulfide nanosheets for ultrasensitive aptasensor design toward Alzheimer’s diagnosis applications - Bayu Tri Murti; Yi-June Huang; Athika Darumas Putri; Chuan-Pei Lee; Chien-Ming Hsieh; Shih-Min Wei; Meng-Lin Tsai; Chih-Wei Peng; Po-Kang Yang (Chemical Engineering Journal, 2023)

Construction of anodic electron transfer chain based on CuCl2/TiOSO4 synergetic mediators for highly efficient conversion of biomass wastes into electricity at low temperature - Chenxing She; Xihong Zu; Zhiheng Yang; Liheng Chen; Zixin Xie; Hao Yang; Dongjie Yang; Guobin Yi; Yanlin Qin; Xuliang Lin; Wenli Zhang; Huafeng Dong; et al. (Chemical Engineering Journal, 2023)

Hybrid renewable energy systems involving thermochemical conversion process for waste-to-energy strategy - Jechan Lee; Kun-Yi Andrew Lin; Sungyup Jung; Eilhann E. Kwon (Chemical Engineering Journal, 2023)

An S-scheme CdS/K2Ta2O6 heterojunction photocatalyst for production of H2O2 from water and air - Cui Lai; Mengyi Xu; Fuhang Xu; Bisheng Li; Dengsheng Ma; Yixia Li; Ling Li; Mingming Zhang; Danlian Huang; Lin Tang; Shiyu Liu; Huchuan Yan; et al. (Chemical Engineering Journal, 2023)

Adjusting charge kinetics of conjugated polymers via integration of LSPR effect with homojunction - Mingjuan Zhang; Lin Tang; Abing Duan; Yi Zhang; Fengjiao Xiao; Yuan Zhu; Jiajia Wang; Chengyang Feng; Nian Yin (Chemical Engineering Journal, 2023)

Unravelling the formation mechanism and performance of nitrogen, sulfur codoped biochar as peroxymonosulfate activator for gatifloxacin removal - Zheng-Yi Choong; Mohamed Faisal Gasim; Kun-Yi Andrew Lin; Tuan Sherwyn Hamidon; Hazwan Hussin; Wen-Da Oh (Chemical Engineering Journal, 2023)

Multi-responsive graphene quantum dots hybrid self-healing structural color hydrogel for information encoding and encryption - Jingye Yan; Guoyi Pan; Wenjing Lin; Zilun Tang; Jieheng Zhang; Jiaxin Li; Wenping Li; Xiaofeng Lin; Hongsheng Luo; Guobin Yi (Chemical Engineering Journal, 2023)

Capture of iodine gas by Bi0 modified silica with different morphologies: Influence of pore characteristic on the stable and unstable forms of adsorption - Yi Ding; Weijie Fan; Qiang Xian; Hui Dan; Lin Zhu; Tao Duan (Chemical Engineering Journal, 2023)

In-situ growth of bimetallic FeCo-MOF on magnetic biochar for enhanced clearance of tetracycline and fruit preservation - Yi-Cai Jiang; Meng-Fan Luo; Zi-Nuo Niu; Si-Yuan Xu; Yue Gao; Yuan Gao; Wen-Juan Gao; Jing-Jing Luo; Rui-Lin Liu (Chemical Engineering Journal, 2023)

Intelligent films of marine polysaccharides and purple cauliflower extract for food packaging and spoilage monitoring - Han-Lun Huang; I-Lin Tsai; Chi Lin; Yu-Hao Hang; Yi-Cheng Ho; Min-Lang Tsai; Fwu-Long Mi (Carbohydrate Polymers, 2023)

Effects of a novel hybrid polymer material on the hydro-mechanical behavior of subgrade silts considering freeze-thaw cycles - Xiao-ning Zhang; Xin-zhuang Cui; Lu-qiang Ding; Ji-yuan Luan; Yi-lin Wang; Peng Jiang; Jian-wen Hao (Cold Regions Science and Technology, 2023)

Clustered regularly interspaced short palindromic repeats (CRISPR) technology and genetic engineering strategies for microalgae towards carbon neutrality: A critical review - Tse-Min Lee; Jia-Yi Lin; Tsung-Han Tsai; Ru-Yin Yang; I-Son Ng (Bioresource Technology, 2023)

Thermoregulation and subjective thermal perception of N95 respirator users: Influence of significant workloads - Yi-Chun Lin; Hui-Chen Wei; Chen-Peng Chen (Building and Environment, 2023)

CFD simulations of effects of recirculation mode and fresh air mode on vehicle cabin indoor air quality - Tong-Bou Chang; Yu-Sheng Lin; Yi-Tian Hsu (Atmospheric Environment, 2023)

Mycorrhizal responsiveness of modern hexaploid wheat and ancestral species under different soil fertility conditions - Lin Mao; Yanan Zhao; Hao Xi; Qi Zhang; Huyuan Feng; Xianfeng Yi; Yongjun Liu (Plant and Soil, 2023)

Angelica dahurica attenuates melanogenesis in B16F0 cells by repressing Wnt/β-catenin signaling - Chien-Liang Fang; Debakshee Goswami; Chia-Hua Kuo; Cecilia Hsuan Day; Mei-Yi Lin; Tsung-Jung Ho; Liang-Yo Yang; Dennis Jine-Yuan Hsieh; Tzu-Kai Lin; Chih-Yang Huang (Molecular & Cellular Toxicology, 2023)

Andrographolide ameliorates hepatic steatosis by suppressing FATP2-mediated fatty acid uptake in mice with nonalcoholic fatty liver disease - Li-Sha Ran; Ya-Zeng Wu; Yi-Wen Gan; Hong-Lian Wang; Li-Juan Wu; Chun-Mei Zheng; Yao Ming; Ran Xiong; Yong-Lin Li; Shi-Hang Lei; Xue Wang; Xiao-Qing Lao; et al. (Journal of Natural Medicines, 2023)
Excessive intrahepatocellular lipid accumulation or steatosis is caused by abnormal lipid metabolism and a common character of nonalcoholic fatty liver disease (NAFLD), which may progress into cirrhosis and hepatocellular cancer. Andrographolide (Andro) is the primary active ingredient extracted from Andrographis paniculata , showing a protective role against dietary steatosis with the mechanism not fully understood. In this study, we showed that administration of Andro (50, 100, and 200 mg/kg/day for 8 weeks, respectively) attenuated obesity and metabolic syndrome in high-fat diet (HFD)-fed mice with improved glucose tolerance, insulin sensitivity, and reduced hyperinsulinemia, hyperglycemia, and hyperlipidemia. HFD-fed mice presented hepatic steatosis, which was significantly prevented by Andro. In vitro, Andro decreased the intracellular lipid droplets in oleic acid-treated LO2 cells. The selected RT-PCR array revealed a robust expression suppression of the fatty acid transport proteins (FATPs) by Andro treatment. Most importantly, we found that Andro consistently reduced the expression of FATP2 in both the oleic acid-treated LO2 cells and liver tissues of HFD-fed mice. Overexpression of FATP2 abolished the lipid-lowering effect of Andro in oleic acid-treated LO2 cells. Andro treatment also reduced the fatty acid uptake in oleic acid-treated LO2 cells, which was blunted by FATP2 overexpression. Collectively, our findings reveal a novel mechanism underlying the anti-steatosis effect of Andro by suppressing FATP2-mediated fatty acid uptake, suggesting the potential therapeutic application of Andro in the treatment of NAFLD. Graphical abstract

Spatio-temporal association mining of intercity PM2.5 pollution: Hubei Province in China as an example - Jiangping Chen; Xiaofeng Song; Lin Zang; Feiyue Mao; Jianhua Yin; Yi Zhang (Environmental Science and Pollution Research, 2023)

Spatiotemporal impacts of climate change and human activities on water resources and ecological sensitivity in the Mekong subregion in Cambodia - Yi Lin; Yu Rong; Lang Li; Fengting Li; Hanchao Zhang; Jie Yu (Environmental Science and Pollution Research, 2023)

Innate and Adaptive Immune Responses Induced by Aspergillus fumigatus Conidia and Hyphae - Yingzhi Luo; Fang Liu; Lin Deng; Jie Xu; Qingtao Kong; Yi Shi; Hong Sang (Current Microbiology, 2023)

Acinetobacter faecalis Sp. Nov., Isolated from Elephant Faeces - Xue-Mei Chen; De-Feng An; Si-Rong He; Shao-Juan Yang; Zu-Zhen Yang; Lian-Shuang Xiong; Gui-Ding Li; Ming-Guo Jiang; Cheng-Lin Jiang; Yi Jiang (Current Microbiology, 2023)

A symbiosis between Euploea butterflies and yeasts - Wan-Rou Lin; Yi-Ping Chang; Hui-Lin Wu; I-Cheng Hsu; Pi-Han Wang (Symbiosis, 2023)

Leveraging single-cell Raman spectroscopy and single-cell sorting for the detection and identification of yeast infections - Jingkai Wang; Siyu Meng; Kaicheng Lin; Xiaofei Yi; Yixiang Sun; Xiaogang Xu; Na He; Zhiqiang Zhang; Huijie Hu; Xingwang Qie; Dayi Zhang; Yuguo Tang; et al. (Analytica Chimica Acta, 2023)

Two types of cold waves affecting northeast China and the corresponding different key regions of precedent sea ice and sea surface temperature - Yihe Fang; Yitong Lin; Chunyu Zhao; Shiqi Xu; Yi Lin; Yiqiu Yu (International Journal of Climatology, 2022)
Based on the daily minimum temperature data from 199 meteorological stations in northeast China (NEC), the cold wave (CW) processes in winter from 1980 to 2020 are identified. Then, by using the reanalysis 500‐hPa geopotential height data provided by the European Centre for Medium‐Range Weather Forecasts (ECMWF), the CWs are objectively classified into two types (abbreviated as Type 1 and Type 2) according to the corresponding atmospheric circulation through the hierarchical cluster algorithm (HCA). The relationships of the CWs with the Arctic sea sic (SIC) and sea surface temperature (SST) are revealed. For Type 1, the SIC in the north of the Barents Sea–Kara Sea is relatively less in the previous autumn, and a wave train propagating from the polar regions to Northeast Asia is stimulated under the ice–atmosphere interaction. This wave train further cooperates with the positive SST anomaly in the southern Indian Ocean to excite the low‐vortex circulation under the negative phase of Arctic Oscillation (AO) in winter, which is conducive to the occurrence of Type 1. However, the relatively low SST in the western Pacific warm pool in previous autumn stimulates a northward propagating wave train along the meridian, which increases the degree of meridionality of the atmospheric circulation over East Asia and thus indirectly causes the polar‐vortex‐splitting circulation under the positive AO phase, which favours the formation of Type 2. The numerical simulations can well reproduce the observational facts, further confirming the possible impact of the SIC and SST in the previous autumn on the two types of CW over the NEC.

Systematic assessment of GPM IMERG V06 precipitation products with dense rain gauge observations over Zhejiang Province, China - Zaoying Bi; Shanlei Sun; Huayu Shen; Yi Liu; Yongjian Ren; Jinjian Li; Bin Lin (International Journal of Climatology, 2022)
This study systematically assessed the performance of the Integrated Multi‐satellitE Retrievals (IMERG) for Global Precipitation Measurement V06, including the near‐real‐time “Late Run” (IMERG‐L) and the post‐real‐time “Final Run” (IMERG‐F), over Zhejiang Province (ZJP), China. The evaluation was conducted at daily and hourly timescales for a full year and for each season, based on dense rain gauge observations and continuous and categorical validation statistics. For the full year and for each season, IMERG‐F outperformed IMERG‐L in representing the spatial pattern of multiyear mean precipitation. For regional mean of ZJP, IMERG‐F and IMERG‐L overestimated the daily/hourly precipitation for the full year by 6.51 and 4.98%, respectively. Among seasons, the regional mean relative biases for IMERG‐F were between 5.65 and 8.63%; however, for IMERG‐L, they exhibited notable variations with a maximum of 11.09% in fall and a minimum of 0 in spring. Bias composition suggested that the regional mean overestimations were largely due to false bias for the full year and for each season, except in winter, wherein it was due to hit bias. Spatially, the biases for the full year and for each season commonly arose from false and hit biases at daily timescale, and from false and miss biases at hourly timescale. Based on the remaining continuous metrics (i.e., root‐mean‐square‐error [RMSE], correlation coefficient [CC], and Kling–Gupta Efficiency [KGE]) and all categorical metrics, the IMERG daily/hourly performance was acceptable on regional and grid scales throughout the year and in all seasons. From a region‐average perspective, IMERG‐F outperformed IMERG‐L according to CC, RMSE, and KGE, but both products showed the same performance overall based on all categorical metrics; most grids also share these characteristics. This study provides a valuable reference for IMERG developers to improve product accuracy from the perspective of the final postprocessing step and for potential users in ZJP.

The electron transport mechanism of downflow Leersia hexandra Swartz constructed wetland-microbial fuel cell when used to treat Cr(VI) and p-chlorophenol - Yian Wang; Xuehong Zhang; Yi Lin; Hua Lin (Environmental Science and Pollution Research, 2022)

Control measure implications of COVID-19 infection in healthcare facilities reconsidered from human physiological and engineering aspects - Ying-Fei Yang; Yi-Jun Lin; Shu-Han You; Tien-Hsuan Lu; Chi-Yun Chen; Wei-Min Wang; Chung-Min Liao (Environmental Science and Pollution Research, 2022)

Phycospheric bacterial community structure and function succession during the typical harmful macroalgal blooms - Tongfei Qu; Chengzong Hou; Chen Guan; Xinyu Zhao; Jun Chen; Yi Zhong; Jinhui Xu; Zhihao Lin; Yu Xu; Xuexi Tang; Ying Wang (Frontiers in Marine Science, 2022)
Based on the diversity and importance of phycospheric microorganisms as well as their complex interaction with algae, their ecological correlation with algal bloom events has become a research topic of great interest that remains unclear in the natural dynamic process of harmful macroalgal blooms (HMBs). The world’s largest green tides caused by macroalgae Ulva prolifera have occurred in the Yellow Sea for 16 consecutive years, and seriously affected the coastal ecosystem. Here, we monitored the spatiotemporal dynamics of the phycospheric bacterial community during the U . prolifera green tide bloom. The 73-day continuous field survey covered the whole process of initial invasion until the extinction of the green tide. The phycospheric bacterial community has a higher richness than the control seawater bacteria; in addition, it has more enriched taxa with organic nutrition preference and environmental pressure adaption, such as Bacteroidetes, Firmicutes, and Desulfobacterota. The same differences in populations and functional profiles were observed among the epiphytic bacterial and phycospheric seawater bacterial communities, which may be driven by the spatial heterogeneity of biogenic elements (e.g., organic nutrients and oxygen) among the habitats. Significant succession occurred in both the epiphytic bacterial and phycospheric seawater bacterial communities; their diversity and richness exhibited significant heterogeneity variation patterns, and their community structure became more similar in late phases. Our study revealed that macroalgal phycospheric microbial communities have a highly complex and dynamic composition and variable ecological functions, which indicate that phycospheric microorganisms are closely related to the fate of HMBs and may have the profound effect coastal biogeochemical cycles.

Prediction of Groundwater Quality Using Seven Types of First-Order Univariate Grey Model in the Chishan Basin, Taiwan - Tzu-Yi Pai; Ray-Shyan Wu; Ching-Ho Chen; Huang-Mu Lo; Terng-Jou Wan; Min-Hsin Liu; Wei-Cheng Chen; Yi-Ping Lin; Chun-Tse Hsu (Water, Air, & Soil Pollution, 2022)

Efficacy and Safety of Recombinant Human Prourokinase in Acute Ischemic Stroke: A Phase IIa Randomized Clinical Trial - Haiqing Song; Yuan Wang; Qingfeng Ma; Huisheng Chen; Bo Liu; Yi Yang; Jianguo Zhu; Shigang Zhao; Xiaoping Jin; Yongqiu Li; Yanyong Wang; Runxiu Zhu; et al. (Translational Stroke Research, 2022)

Combined analysis of mRNA and miRNA reveals the banana potassium absorption regulatory network and validation of miRNA160a - Wenliang Chen; Tao Dong; Yinglong Chen; Ping Lin; Chuqiao Wang; Kelin Chen; Yi Tang; Mingyuan Wang; Jianfu Liu; Hailing Yu (Plant Molecular Biology, 2022)

Aloe polysaccharide promotes osteogenesis potential of adipose-derived stromal cells via BMP-2/Smads and prevents ovariectomized-induced osteoporosis - Xue-wei Yao; He-dong Liu; Mao-xian Ren; Tian-lin Li; Wen-kai Jiang; Zhi Zhou; Zhi-yi Liu; Min Yang (Molecular Biology Reports, 2022)
Background Aloe polysaccharide (AP) is a type of an active macromolecule of Aloe vera, which contributes to its function. However, whether AP possesses anti-osteoporosis properties is unknown. Methods Adipose-derived stromal cells were treated with different concentrations of AP. Early and late osteogenesis were, respectively, evaluated by ALP and Alizarin Red S staining. The effect of AP on the processes of adipogenesis inhibition in ADSCs was analyzed by oil red O staining. Western blot was used to assess the expression of osteogenic and adipogenic related factors. Then, Noggin was administered to further confirm the mechanism by which AP promotes the osteogenesis of ADSCs. Finally, 40 female SD rats were classified into a bilateral laparotomy group (Sham group) and three bilateral ovariectomy groups: OVX group, OVX + AP group, and OVX + AP + Noggin group. The bilateral rat femurs were collected to perform micro-CT scanning, HE, Masson trichrome, and Oil red O staining. Results The results indicated that AP could increase ALP expression and calcium deposition. Through molecular mechanisms, AP promotes the protein expression of COL1A1, OPN, and ALP in ADSCs, but downregulates the expression of PPARγ. Also, AP directs ADSCs’ fate by stimulating the BMP2/Smads signaling pathway. In vivo, the rat AP-treated had more trabecular bone than the OVX rat, indicating partial protection from cancellous bone loss after treatment with AP. Conclusion Our results show that AP may promote osteogenesis of ADSCs through BMP-2/Smads signaling pathway and inhibits lipogenic differentiation. Thus, AP might be a promising alternative medicine to treat postmenopausal osteoporosis.

Development of Two Recombinase Polymerase Amplification EXO (RPA-EXO) and Lateral Flow Dipstick (RPA-LFD) Techniques for the Rapid Visual Detection of Aeromonas salmonicida - Shun Zhou; Xujia Zheng; Zongrui Yang; Qing Huang; Jingyuan Yi; Lin Su; Baoshan Guo; Yunji Xiu (Marine Biotechnology, 2022)

Effects of the combined application of biochar-based fertilizer and urea on N2O emissions, nitrifier, and denitrifier communities in the acidic soil of pomelo orchards - Lin Zhao; Qinghua Li; Xiaojie Qian; Hongmei Chen; Fei Wang; Zhigang Yi (Journal of Soils and Sediments, 2022)

AIoT-Based Ergometer for Physical Training in Frail Elderly with Cognitive Decline: A Pilot Randomized Control Trial - Chih-Chun Lin; Li-Chieh Kuo; Yu-Sheng Lin; Chia-Ming Chang; Fang Wen Hu; Yi-Jing Chen; Chun-Tse Lin; Fong-Chin Su (Journal of Medical and Biological Engineering, 2022)
Purpose Reduced physical activity is reported in the elderly, especially in institutional residents. Institutionalized older adults exhibit a high prevalence of frailty. In this work, we developed an artificial intelligence of things (AIoT)-based feedback assistive strengthening ergometer (AIFASE), for the physical strengthening of the elderly with intelligent assistance. Methods We conducted a 12-week intervention in a long-term care facility. In total, 16 participants (84.38 ± 6.0 years; 4 males and 12 females) were recruited with 1:1 randomization of exercise to control groups. The muscle strength of the lower extremities, timed up and go test (TUG), and Short-form Physical Performance Battery (SPPB) of the participants were measured. The AIFASE system allows the clinical staff to record the personal physical performance of the elderly and generates personalized exercise prescriptions accordingly. AIFASE also displays the current usage status of all ergometers and the users’ physiological conditions. The algorithms were developed to generate warning alerts when the training workload was too large by personal physiological detection. AIFASE automatically customized the exercise prescription according to the user’s exercise performance. Results After a 12-week AIFASE intervention, the intervention group exhibited significant improvements in the strength of the hip flexor, Semi-Tandem Stand, and Tandem Stand. Conclusion In this study, we developed an AIoT ergometer that delivered customized physical training prescriptions to improve the physical performance of long-term care facility residents. We believe that the application of AIFASE will help improve the quality of institutional care.

Immunotherapies for the Effective Treatment of Primary Autoimmune Cerebellar Ataxia: a Case Series - Jiao Li; Bo Deng; Wenli Song; Keru Li; Jingwen Ai; Xiaoni Liu; Haocheng Zhang; Yi Zhang; Ke Lin; Guofu Shao; Chunfeng Liu; Wenhong Zhang; et al. (The Cerebellum, 2022)

Two new phenylpropenoid glycosides from the roots of Illicium dunnianum - Yi-lin Wang; Han Li; Ling Song; Yun-hang Gao; Teng-fei Chen (Natural Product Research, 2022)

Correction to: Breeding for disease resistance in soybean: a global perspective - Feng Lin; Sushil Satish Chhapekar; Caio Canella Vieira; Marcos Paulo Da Silva; Alejandro Rojas; Dongho Lee; Nianxi Liu; Esteban Mariano Pardo; Yi-Chen Lee; Zhimin Dong; Jose Baldin Pinheiro; Leonardo Daniel Ploper; et al. (Theoretical and Applied Genetics, 2022)

Breeding for disease resistance in soybean: a global perspective - Feng Lin; Sushil Satish Chhapekar; Caio Canella Vieira; Marcos Paulo Da Silva; Alejandro Rojas; Dongho Lee; Nianxi Liu; Esteban Mariano Pardo; Yi-Chen Lee; Zhimin Dong; Jose Baldin Pinheiro; Leonardo Daniel Ploper; et al. (Theoretical and Applied Genetics, 2022)
Key message This review provides a comprehensive atlas of QTLs, genes, and alleles conferring resistance to 28 important diseases in all major soybean production regions in the world. Abstract Breeding disease-resistant soybean [ Glycine max (L.) Merr.] varieties is a common goal for soybean breeding programs to ensure the sustainability and growth of soybean production worldwide. However, due to global climate change, soybean breeders are facing strong challenges to defeat diseases. Marker-assisted selection and genomic selection have been demonstrated to be successful methods in quickly integrating vertical resistance or horizontal resistance into improved soybean varieties, where vertical resistance refers to R genes and major effect QTLs, and horizontal resistance is a combination of major and minor effect genes or QTLs. This review summarized more than 800 resistant loci/alleles and their tightly linked markers for 28 soybean diseases worldwide, caused by nematodes, oomycetes, fungi, bacteria, and viruses. The major breakthroughs in the discovery of disease resistance gene atlas of soybean were also emphasized which include: (1) identification and characterization of vertical resistance genes reside rhg1 and Rhg4 for soybean cyst nematode, and exploration of the underlying regulation mechanisms through copy number variation and (2) map-based cloning and characterization of Rps11 conferring resistance to 80% isolates of Phytophthora sojae across the USA. In this review, we also highlight the validated QTLs in overlapping genomic regions from at least two studies and applied a consistent naming nomenclature for these QTLs. Our review provides a comprehensive summary of important resistant genes/QTLs and can be used as a toolbox for soybean improvement. Finally, the summarized genetic knowledge sheds light on future directions of accelerated soybean breeding and translational genomics studies.

Detection of the role of intestinal flora and tryptophan metabolism involved in antidepressant-like actions of crocetin based on a multi-omics approach - Susu Lin; Qiaoqiao Li; Zijin Xu; Ziwei Chen; Yi Tao; Yingpeng Tong; Ting Wang; Suhong Chen; Ping Wang (Psychopharmacology, 2022)

Proteomic analysis and identification reveal the anti-inflammatory mechanism of clofazimine on lipopolysaccharide-induced acute lung injury in mice - Bo Yang; Zhan Gao; Qi-Shuang Li; Xiang-Ye Zhang; Lan Song; Yi-Ni Wang; Xin-Yue Wang; Lin-Lin Ji; Hong-Liang Xu; Hui Xie; Fu-Kai Feng; Xiao-Ping Li; et al. (Inflammation Research, 2022)

Activity concentrations and bioconcentration factors (BCFs) of natural radionuclides (40 K, 226Ra, and 232Th) from cultivated substrates to mushrooms - Wei-Hsiang Huang; Chih-Chung Lin; Yung-Yu Liu; Chao-Min Huang; Yi-Lung Yeh; Ting-Chien Chen (Environmental Science and Pollution Research, 2022)

A new numerical model of ring shear tester for shear band soil considering friction-induced thermal pressurization - Neng-hao Zhao; Kun Song; Rong-tang Zhang; Qing-lin Yi (Journal of Mountain Science, 2022)

A histological study of vascular wall resident stem cells in venous malformations - Hou-Fu Xia; Wen-Qiang Lai; Gao-Hong Chen; Ye Li; Qi-Hui Xie; Yu-Lin Jia; Gang Chen; Yi-Fang Zhao (Cell and Tissue Research, 2022)

Behavioral and transcriptomic changes in butenolide treated larvae of the cosmopolitan fouling bryozoan Bugulina (Bugula) neritina - Jin-You Liang; Yi-Fan Cheng; Xiao-Lin Huang; Ying Xu; Yue Him Wong; Yu Zhang (Frontiers in Marine Science, 2022)
The arborescent bryozoan Bugulina neritina is a cosmopolitan fouling species in sub-tropical to sub-temperate waters. The butenolide compound 5-octylfuran-2(5H)-one (hereafter named butenolide) reportedly inhibits larval settlement of B. neritina , but its effect on the larval behavioral and transcriptomic responses remained unclear. We report that 10 μg mL -1 or higher concentration of butenolide and/or prolonged treatment (10 h or longer) resulted in significant increase in larval mortality and prominent spiral larval swimming behavior. The transcriptomic analyses not only revealed up-regulation of typical stress-related protein genes in response to 10 mg mL -1 butenolide treatment, but also indicated up-regulation of mucin , synaptic genes and nitric oxide signaling genes. In addition, the expression of developmental genes and lipid biosynthesis genes were also affected. Overall, our larval behavior and transcriptome analyses reflected the impact of butenolide on the metabolism, neuronal and molecular signaling in B. neritina larvae.

Surfactin isoforms isolated from a mushroom derived Bacillus halotolerans DMG-7-2 - Guo-Feng Zhou; Lin Yang; Shu-Hua Zhang; Yi Wang; Yu Yang; Rui Xu; Xue Zhao; Dan Nie; Junjie Shan; Cheng-Bin Cui; Chang-Wei Li (Natural Product Research, 2022)

Coastal landscape pattern optimization based on the spatial distribution heterogeneity of ecological risk - Lin Yi; Sunjie Ma; Shiwei Tao; Jiyi Zhang; Jiujuan Wang (Frontiers in Marine Science, 2022)
The increasingly intensified development of coastal cities causes excessive consumption of natural resources, leading to environmental damage and increasing conflict between development and ecological protection. In addition to emphasizing ecological development, planners should pay more attention to the practical optimization and regulation of the developed landscape pattern. Taking Dafeng as an example, this study constructs a landscape-pattern optimization method suitable for the spatial distribution heterogeneity of ecological risk-level units in the coastal zone. The study is based on (a) an analysis of the composition and evolution characteristics of Dafeng’s coastal landscape elements, (b) the landscape pattern index of the ecosystem’s overall risk assessment, and (c) the minimal cumulative resistance (MCR) model. The study uses an ecosystem service value to build a resistance model by analyzing the medium and high-risk composition and distribution characteristics of space unit elements. Finally, 23 ecological sources, 14 ecological nodes, and 17 ecological corridors (total length 169.63 km) were built. The optimized coastal zone landscape pattern jointly protects the landscape area of high ecological value by 462.02 km 2 . The total ecological value is 105,01.71 million yuan. Landscape connectivity has been optimized, as well as the ecosystem’s stability and total service value. The optimization method proposed in this paper can reduce the protection area and cost. The spatial optimization unit is highly targeted, providing new ideas for the coastal cities to implement their ecological development and protection strategies.

Vitamin D regulates transepithelial acid secretion in zebrafish (Danio rerio) larvae - Chia-Hao Lin; Sian-Tai Liu; Yu-Chun Wang; Yi-Ling Tsou; Huei-Jyun Hu (Frontiers in Marine Science, 2022)
Maintenance of an acid-base balance is essential for normal physiological processes in vertebrates. Freshwater fishes live in an aquatic environment with variable pH, and their buffering capacity for acid-base balance in body fluids is weak. Thus, after acid exposure, fishes secrete excess acid to prevent internal acidosis. Acid-secreting ionocytes present in the adult gills and embryonic skin are primarily responsible for acid secretion, and H + -ATPase and Na + /H + exchanger 3 (NHE3) are the two main transporters responsible for apical acid secretion. Vitamin D is a well-known hormone involved in the maintenance of Ca 2+ homeostasis and is suggested to be involved in acid-base regulation by modulating the activity and/or mRNA expression of NHE3 in mammalian models. It remains unclear whether vitamin D is involved in acid secretion in fishes. The aim of the present study was to use zebrafish as a model to determine whether vitamin D and its receptors influence acid secretion. Our results indicated that the levels of 1α, 25-dihydroxyvitamin D 3 (1α,25(OH) 2 D 3 ), the bioactive vitamin D, were significantly increased in 3 days post-fertilization zebrafish larvae after exposure to acidic freshwater (AFW, pH 4.0). Exogenous 1α,25(OH) 2 D 3 (20 μg/L) incubation substantially enhanced the mRNA expression of acid-secreting transporters and acid secretion at the skin of the entire body and each H + -ATPase-rich cell (HRC), a type of acid-secreting ionocyte. Furthermore, the expression of vitamin D receptors (VDRs) was identified in HRCs of zebrafish. When both VDRa and VDRb were knocked down, acid secretion and the mRNA expression of acid-secreting transporters were significantly decreased. Moreover, double knockdown of VDRa/b prevented the increase in acid secretion induced by AFW and 1α,25(OH) 2 D 3 treatment. This study is the first to indicate that vitamin D is involved in acid secretion in fish.

Wavefield-reconstructed least-squares reverse time migration with dynamic constraint factor - Yi Ding; Zhenchun Li; Kai Zhang; Yuzhao Lin (Acta Geophysica, 2022)

Can artificial intelligence improve green economic growth? Evidence from China - Yu Qian; Jun Liu; Lifan Shi; Jeffrey Yi-Lin Forrest; Zhidan Yang (Environmental Science and Pollution Research, 2022)

Lytic Bacteriophage as a Biomaterial to Prevent Biofilm Formation and Promote Neural Growth - Zi-Hao Liu; Ming-Tse Chiang; Hsin-Yi Lin (Tissue Engineering and Regenerative Medicine, 2022)

How rainfalls influence urban traffic congestion and its associated economic losses at present and in future: taking cities in the Beijing-Tianjin-Hebei region, China for example? - Yi Zhou; Sicheng Mao; Haile Zhao; Guoliang Zhang; Xin Chen; Yuling Jin; Lin Xu; Zhihua Pan; Pingli An; Fei Lun (Theoretical and Applied Climatology, 2022)

Temporal and spatial distribution characteristics of drought and flood considering the influence of underlying surface in Hainan Island, tropical areas of China - Changqing Ye; Yi Zou; Yanhu He; Youwen Lin; Dan Li; Lirong Zhu (Theoretical and Applied Climatology, 2022)

Identification of serum metabolites enhancing inflammatory responses in COVID-19 - Chen-Song Zhang; Bingchang Zhang; Mengqi Li; Xiaoyan Wei; Kai Gong; Zhiyong Li; Xiangyang Yao; Jianfeng Wu; Cixiong Zhang; Mingxia Zhu; Lei Zhang; Xiufeng Sun; et al. (Science China Life Sciences, 2022)

Predicting Lumbar Vertebral Osteopenia Using LvOPI Scores and Logistic Regression Models in an Exploratory Study of Premenopausal Taiwanese Women - Chun-Wen Chen; Yi-Jui Liu; Shao-Chieh Lin; Chien-Yuan Wang; Wu-Chung Shen; Der-Yang Cho; Tung-Yang Lee; Cheng-Hsuan Juan; Cheng-En Juan; Kai-Yuan Cheng; Chun-Jung Juan (Journal of Medical and Biological Engineering, 2022)
Purpose To propose hybrid predicting models integrating clinical and magnetic resonance imaging (MRI) features to diagnose lumbar vertebral osteopenia (LvOPI) in premenopausal women. Methods This prospective study enrolled 101 Taiwanese women, including 53 before and 48 women after menopause. Clinical information, including age, body height, body weight and body mass index (BMI), were recorded. Bone mineral density (BMD) was measured by the dual-energy X-ray absorptiometry. Lumbar vertebral fat fraction (LvFF) was measured by MRI. LvOPI scores (LvOPISs) comprising different clinical features and LvFF were constructed to diagnose LvOPI. Statistical analyses included normality tests, linear regression analyses, logistic regression analyses, group comparisons, and diagnostic performance. A P value less than 0.05 was considered as statistically significant. Results The post-menopausal women had higher age, body weight, BMI, LvFF and lower BMD than the pre-menopausal women (all P < 0.05). The lumbar vertebral osteoporosis group had significantly higher age, longer MMI, and higher LvFF than the LvOPI group (all P < 0.05) and normal group (all P < 0.005). LvOPISs (AUC, 0.843 to 0.864) outperformed body weight (0.747; P = 0.0566), BMI (0.737; P < 0.05), age (0.649; P < 0.05), and body height (0.5; P < 0.05) in diagnosing LvOPI in the premenopausal women. Hybrid predicting models using logistic regression analysis (0.894 to 0.9) further outperformed all single predictors in diagnosing LvOPI in the premenopausal women ( P < 0.05). Conclusion The diagnostic accuracy of the LvOPI can be improved by using our proposed hybrid predicting models in Taiwanese premenopausal women.

Theranostic Radiolabeled Nanomaterials for Molecular Imaging and potential Immunomodulation Effects - Chao-Cheng Chen; Yang-Hsiang Chan; Syue-Liang Lin; Huihua Kenny Chiang; Yi-Jang Lee; Hui-Yen Chuang (Journal of Medical and Biological Engineering, 2022)

Identification of a 5-gene-risk score model for predicting luminal A-invasive lobular breast cancer survival - Yi-Huan Chen; Tao-Feng Zhang; Yi-Yuan Liu; Jie-Hua Zheng; Wei-Xun Lin; Yao-Kun Chen; Jie-Hui Cai; Juan Zou; Zhi-Yang Li (Genetica, 2022)

Clinical profiles and antimicrobial resistance patterns of invasive Salmonella infections in children in China - Wen Song; Qingwen Shan; Yue Qiu; Xianyao Lin; Chunhui Zhu; Zhiqiang Zhuo; Caihong Wang; Jianning Tong; Rui Li; Chaomin Wan; Yu Zhu; Minxia Chen; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2022)
Invasive Salmonella infections result in a significant burden of disease including morbidity, mortality, and financial cost in many countries. Besides typhoid fever, the clinical impact of non-typhoid Salmonella infections is increasingly recognized with the improvement of laboratory detection capacity and techniques. A retrospective multicenter study was conducted to analyze the clinical profiles and antimicrobial resistance patterns of invasive Salmonella infections in hospitalized children in China during 2016–2018. A total of 130 children with invasive Salmonella infections were included with the median age of 12 months (range: 1–144 months). Seventy-nine percent of cases occurred between May and October. Pneumonia was the most common comorbidity in 33 (25.4%) patients. Meningitis and septic arthritis caused by nontyphoidal Salmonella (NTS) infections occurred in 12 (9.2%) patients and 5 (3.8%) patients. Patients < 12 months (OR: 16.04) and with septic shock (OR: 23.4), vomit (OR: 13.33), convulsion (OR: 15.86), C-reactive protein (CRP) ≥ 40 g/L (OR: 5.56), and a higher level of procalcitonin (PCT) (OR: 1.05) on admission were statistically associated to an increased risk of developing meningitis. Compared to 114 patients with NTS infections , 16 patients with typhoid fever presented with higher levels of CRP and PCT ( P < 0.05). The rates of resistance to ampicillin, sulfamethoxazole/trimethoprim, ciprofloxacin, and ceftriaxone among Salmonella Typhi and NTS isolates were 50% vs 57.3%, 9.1% vs 24.8%, 0% vs 11.2%, and 0% vs 9.9%, respectively. NTS has been the major cause of invasive Salmonella infections in Chinese children and can result in severe diseases. Antimicrobial resistance among NTS was more common.

Dynamic networks of P300-related process - Qin Tao; Lin Jiang; Fali Li; Yuan Qiu; Chanlin Yi; Yajing Si; Cunbo Li; Tao Zhang; Dezhong Yao; Peng Xu (Cognitive Neurodynamics, 2022)

Immune responses to Vibrio vulnificus formalin‐killed vaccine and ghost vaccine in Scophthalmus maximus - Shun Zhou; Ying Li; Jingyuan Yi; Xujia Zheng; Qing Huang; Lin Su; Baoshan Guo; Zongrui Yang; Yunji Xiu (Journal of Fish Diseases, 2022)
In this research, Vibrio vulnificus formalin‐killed (FKCs) vaccine and ghost (VVGs) vaccine were successfully developed, and shown to prevent vibriosis of Scophthalmus maximus resulting from V. vulnificus. The antibody titre of FKCs and VVGs vaccine was 1: 2 8 and 1: 2 11 . The RPS of FKCs and VVGs vaccine was 60% and 80%. In order to improve the understanding of vaccine protection mechanism, transcriptome data was used to analyse the immune response of S. maximus infected with V. vulnificus after vaccination with FKCs and VVGs vaccine. In the SmCon and SmIV groups, a series of innate immune‐related genes were upregulated (such as, TLR5, Tp12, AP‐1 and IL‐1β) or downregulated (such as, CASP6 and CASP8), which suggested that the immune protection mechanism induced by inactivated vaccine was similar to that of autoimmune response. In the SmIV and SmGho group, a number of innate and adaptive immune‐related genes (such as, STAT1, IFN‐γ and MHC Ia) were activated, in which the expression of these genes was higher in SmGho, and VVGs vaccine induced stronger innate and acquired immune responses. In conclusion, the results lay a foundation for further study on the molecular mechanisms of immune protection induced by VVGs vaccine and FKCs vaccine.

Microbial transformation of distinct exogenous substrates into analogous composition of recalcitrant dissolved organic matter - Jie Lian; Xiaoxuan Zheng; Xiaocun Zhuo; Yi‐Lung Chen; Chen He; Qiang Zheng; Ta‐Hui Lin; Jia Sun; Weidong Guo; Quan Shi; Nianzhi Jiao; Ruanhong Cai (Environmental Microbiology, 2022)

Bioconversion of food waste to crayfish feed using solid-state fermentation with yeast - Qinping Li; Puhong Yi; Jianze Zhang; Yudong Shan; Yongfeng Lin; Ming Wu; Kun Wang; Guangming Tian; Ji Li; Tingheng Zhu (Environmental Science and Pollution Research, 2022)

Effects of fuel injection system and exhaust gas catalytic treatments on PAH emissions from motorcycles - Sheng-Lun Lin; Hongjie Zhang; Lin-Chi Wang; Yen-Yi Lee; Chien-Er Huang (Environmental Science and Pollution Research, 2022)

Effect modification by aging on the associations of nicotine exposure with cognitive impairment among Chinese elderly - Jian Hou; Chao Huang; Bo Zhu; Wei Liu; Qing-qing Zhu; Lu Wang; Tian Li; Chun-jie Yuan; Shao-yang Lai; De-sheng Wu; Fei-qi Zhu; Jia-fei Zhang; et al. (Environmental Science and Pollution Research, 2022)

Hippocampal Iron Accumulation Impairs Synapses and Memory via Suppressing Furin Expression and Downregulating BDNF Maturation - Yating Zhang; Xue Bai; Yi Zhang; Shanshan Yao; Yiduo Cui; Lin-Hao You; Peng Yu; Yan-Zhong Chang; Guofen Gao (Molecular Neurobiology, 2022)

Two new clerodane diterpenoids and a new pyran-2-one derivative with anti-neuroinflammatory activities from Croton crassifolius - Zhi-Peng Ling; Qing Tang; Can-Jie Li; Jin-Lin Tan; Hai-Yue Zhao; Yi-Kun Hao; Zhao-Chun Zhan; Zhong-Nan Wu; Yu-Bo Zhang; Qing Zheng; Guo-Cai Wang (Journal of Natural Medicines, 2022)

Validity Analysis of the Morphological Identification of Three Highly Morphologically Similar Species Belonging to the Genus Niviventer (Rodentia: Muridae) - Yao-Yao Li; Hao-Tian Li; Jia-Wei Hao; Chen-Yi Zhang; Guan-Ze Liu; Xing-Han Lin; Xiao-Qing Sun; Guo-Chen Zang; Yu-Chun Li (Journal of Mammalian Evolution, 2022)

Monitoring glaciers in the Chenab basin with SBAS InSAR technology - Yue-kai Ding; Rui Liu; Yi-fei Fan; Ling-xiang Zhou; Qin Ji; Hong Zhang; Zuo-lin Xiao (Journal of Mountain Science, 2022)

Endothelial cells induce degradation of ECM through enhanced secretion of MMP14 carried on extracellular vesicles in venous malformation - Gao-Hong Chen; Jie-Gang Yang; Hou-Fu Xia; Lin-Zhou Zhang; Yin-Hsueh Chen; Kui-Ming Wang; Xu Duan; Lian-Zhi Wu; Yi-Fang Zhao; Gang Chen (Cell and Tissue Research, 2022)

Process Performance and Microbial Communities in Anaerobic Co-digestion of Sewage Sludge and Food Waste with a Lower Range of Carbon/Nitrogen Ratio - Yi Zheng; Pan Wang; Xinyu Yang; Peiru Lin; Yongjing Wang; Mengmeng Cheng; Lianhai Ren (BioEnergy Research, 2022)

An integrated analysis of pond ecosystem around Poyang Lake: assessment of water quality, sediment geochemistry, phytoplankton and benthic macroinvertebrates diversity and habitat condition - Wei Liu; Qiyang Tan; Yifan Chu; Jinmei Chen; Lingli Yang; Lin Ma; Yi Zhang; Zhenbin Wu; Feng He (Aquatic Ecology, 2022)

Erratum to: Stratospheric Ozone-induced Cloud Radiative Effects on Antarctic Sea Ice - Yan Xia; Yongyun Hu; Jiping Liu; Yi Huang; Fei Xie; Jintai Lin (Advances in Atmospheric Sciences, 2022)
Erratum to: Xia, Y., Y. Y. Hu, J. P. Liu, Y. Huang, F. Xie, and J. T. Lin, 2020: Stratospheric ozone-induced cloud radiative effects on Antarctic sea ice. Adv. Atmos. Sci. , 37 (5), 505−514, https://doi.org/10.1007/s00376-019-8251-6 . This article has changed from access by subscription to OA.

Climatology of aerosol types and their vertical distribution over East Asia based on CALIPSO lidar measurements - Lu Gui; Minghui Tao; Yi Wang; Lunche Wang; Liangfu Chen; Changqing Lin; Jinhua Tao; Jun Wang; Chao Yu (International Journal of Climatology, 2022)
Aerosol vertical distribution generally determines their health impacts and climate effects. By using long‐term (2007–2019) CALIPSO lidar measurements, we present a large‐scale insight into the climatology of aerosol types and their vertical structure over East Asia. Despite the low sampling frequency, comparison with MODIS aerosol optical depth (AOD) shows that the integrated CAIPSO vertical extinction can reasonably reproduce spatial patterns of the aerosol loading. With the unique advantage of active detection, CALIPSO reveals an obvious enhancement of the night‐time AOD due to worse diffusion conditions. Moreover, long‐range transport of different aerosols including dust, polluted dust, and smoke has substantial contribution to the aerosol loading over East Asia. Pure dust particles are mainly concentrated over the deserts with notable dust transport belts (dust AOD > 0.2 at 532 nm) along downwind regions during winter and spring. By contrast, polluted dust is prevalent over the downstream eastern China with much higher AODs throughout the year. In particular, AOD of polluted dust (~0.5) is higher in winter rather than in spring, which is consistent with their seasonal occurrences. Smoke aerosols usually appear in the night‐time over southern China. The top heights of aerosols are around 4–6 km, with dust and smoke having higher extinction at upstream regions. The climatology of these aerosol types and vertical distribution can provide a significant constraint for associated studies of air quality and climate effects.

Potential millennial‐scale avian declines by humans in southern China - Feng Dong; Qiang Zhang; Yi‐Lin Chen; Fu‐Min Lei; Shou‐Hsien Li; Fei Wu; Xiao‐Jun Yang (Global Change Biology, 2022)
Mounting observational records demonstrate human‐caused faunal decline in recent decades, while accumulating archaeological evidence suggests an early biodiversity impact of human activities during the Holocene. A fundamental question arises concerning whether modern wildlife population declines began during early human disturbance. Here, we performed a population genomic analysis of six common forest birds in East Asia to address this question. For five of them, demographic history inference based on 25–33 genomes of each species revealed dramatic population declines by 4‐ to 48‐fold over millennia (e.g. 2000–5000 thousand years ago). Nevertheless, summary statistics detected nonsignificant correlations between these population size trajectories and Holocene temperature variations, and ecological niche models explicitly predicted extensive range persistence during the Holocene, implying limited demographic consequence of Holocene climate change. Further analyses suggest high negative correlations between the reconstructed population declines and human disturbance intensities and indicate a potential driver of human activities. These findings provide a deep‐time and large‐scale insight into the recently recognized avifaunal decline and support an early origin hypothesis of human effects on biodiversity. Overall, our study sheds light on the current biodiversity crisis in the context of long‐term human–environment interactions and offers a multi‐evidential framework for quantitatively assessing the ecological consequences of human disturbance.

A strategy for establishing an efficient somatic embryo regeneration system in Castanea mollissima Blume - Xiao-wei Li; Zhi-lin Sun; Yue-rong Gao; Jing-yi Ge; Yu-zhen Tian; Bing Liu; Shi-kan Sun; Ke-feng Fang; Ling Qin; Qing-qin Cao (Plant Cell, Tissue and Organ Culture (PCTOC), 2022)

Population Pharmacokinetic Evaluation with External Validation of Tacrolimus in Chinese Primary Nephrotic Syndrome Patients - Lin Yang; Nan Yang; Bin Yi; Qi Pei; Zhijun Huang (Pharmaceutical Research, 2022)

Correction to: Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated Encephalopathy by Promoting Ferroptosis Through Regulating miR-9-5p/ TFRC and GOT1 Axis - Xue-biao Wei; Wen-qiang Jiang; Ju-hao Zeng; Lin-qiang Huang; Hong-guang Ding; Yuan-wen Jing; Yong-li Han; Yi-chen Li; Sheng-long Chen (Molecular Neurobiology, 2022)

Integrated Analyses of miRNome and Transcriptome Reveal the Critical Role of miRNAs Toward Heat Stress Response in Isochrysis galbana - Jia-Yi Cao; Si-Min Xu; Ying-Ying Wang; Xie-Dan Long; Shuo-Nan Ma; Cheng-Xu Zhou; Ji-Lin Xu; Xiao-Jun Yan (Marine Biotechnology, 2022)

The efficacy and safety of TNF inhibitor (golimumab) as salvage treatment in patients with refractory noninfectious uveitis - Yi Jin; Shanshan Lu; You Lin; Xiaoyue Mou (Inflammopharmacology, 2022)

Effects of U on the growth, reactive oxygen metabolism and osmotic regulation in radish (Raphanus sativus L.) - Guo Wu; Xi Chen; Ting Zheng; Pi-xian Xiao; Ning-ying Zhong; Xiu-lin Yang; Yi Li; Wei Li (Environmental Science and Pollution Research, 2022)

Indirect effect of diabatic heating on Mei-yu frontogenesis - Yang Hu; Yi Deng; Yanluan Lin; Zhimin Zhou; Chunguang Cui; Chao Li; Xiquan Dong (Climate Dynamics, 2022)

Sex differences in microstructural alterations in the corpus callosum tracts in drug-naïve children with ADHD - Qingxia Lin; Xuan Bu; Hong Chen; Yan Liang; Weiqian Wang; Yanhong Yi; Haixi Lin; Lu Lu; Yingxue Gao; Andan Qian; Shuangli Chen; Meihao Wang; et al. (Brain Imaging and Behavior, 2022)

Negative Poisson’s ratio and peripheral strain of an NPR anchor cable - Zhi-gang Tao; Hao-tian Xu; Shu-lin Ren; Long-ji Guo; Ke Qin; Yi-fei Zhu (Journal of Mountain Science, 2022)

Establishment and Characterization of a Fin Cell Line Derived from the Atlantic Salmon Salmo salar and Its Application to Fish Virology Study - Peng Jia; Lirong Lin; La Xu; Meisheng Yi; Kuntong Jia (Journal of Ocean University of China, 2022)

Rhodohalobacter sulfatireducens sp. nov., isolated from a marine solar saltern - Yu-Sheng Wang; Yu-Yan Yue; Yi-Lin Bai; Xu-Yang Zhang; Shuo Wang; Zong-Jun Du (Archives of Microbiology, 2022)

Protein kinase Ime2 is associated with mycelial growth, conidiation, osmoregulation, and pathogenicity in Fusarium oxysporum - Jiling Xiao; Yi Zhang; Ke Yang; Yanying Tang; Lin Wei; Erming Liu; Zhihuai Liang (Archives of Microbiology, 2022)
Fusarium oxysporum f.sp. niveum is one of the most serious diseases impairing watermelon yield and quality. Inducer of meiosis 2 (Ime2) is the founding member of a family of serine/threonine protein kinases and plays important roles in yeasts and other filamentous fungi. In this study, we analyzed the functions of Fo Ime2, the ortholog of Saccharomyces cerevisiae Ime2 in F. oxysporum f.sp. niveum . The FoIme2 -deleted mutants exhibited obvious morphological abnormalities, including slower vegetative growth, more branches in the edge hyphae and a reduction in conidia production. Compared to the wild type, the mutants were hypersensitive to the osmotic stressor NaCl but were more insensitive to the membrane stressor SDS. The deletion of FoIme2 also caused a reduction in pathogenicity. Transcriptional analysis revealed that Fo Ime2 acts downstream of Fo Opy2 which is an upstream sensor of the MAPK kinase cascade. These results indicate that Fo Ime2 is important in the development and pathogenicity of F. oxysporum, and provide new insight for the analysis of the pathogenic mechanism of F. oxysporum.

A multi-isotope analysis on human and pig tooth enamel from prehistoric Sichuan, China, and its archaeological implications - Kuei-chen Lin; Cheng-Yi Lee; Pei-Ling Wang (Archaeological and Anthropological Sciences, 2022)

Assessing the effect of probiotics on tilapia lake virus‐infected tilapia: Transmission and immune response - Ying‐Fei Yang; Jidapa Yamkasem; Win Surachetpong; Yi‐Jun Lin; Shu‐Han You; Tien‐Hsuan Lu; Chi‐Yun Chen; Wei‐Min Wang; Chung‐Min Liao (Journal of Fish Diseases, 2022)
Probiotics have been used to alleviate disease transmission in aquaculture. However, there are limited studies on probiotic use in modulating tilapia lake virus (TiLV). We assessed commercially available probiotic supplements used in TiLV‐infected tilapia and performed mortality and cohabitation assays. We developed a mechanistic approach to predict dose–response interactions of probiotic effects on mortality and immune gene response. We used a susceptible–infected–mortality disease model to assess key epidemiological parameters such as transmission rate and basic reproduction number ( R 0 ) based on our viral load dynamic data. We found that the most marked benefits of probiotics are significantly associated with immune system enhancements (~30%) and reductions in disease transmission (~80%) and R 0 (~70%) in tilapia populations, resulting in a higher tolerance of farming densities (~400 fold) in aquaculture. These findings provide early insights as to how probiotic use‐related factors may influence TiLV transmission and the immune responses in TiLV‐infected tilapia. Our study facilitates understanding the mode of action of probiotics in disease containment and predicting better probiotic dosages in diet and supplements to achieve the optimal culturing conditions. Overall, our analysis assures that further study of rationally designed and targeted probiotics, or mechanistic modelling is warranted on the basis of promising early data of this approach.

Assessing the effective spatial characteristics of input features through physics-informed machine learning models in inundation forecasting during typhoons - Bing-Chen Jhong; Chung-Yi Lin; You-Da Jhong; Hsiang-Kuan Chang; Jung-Lien Chu; Hsi-Ting Fang (Hydrological Sciences Journal, 2022)

Fissistiganoids A and B: two new flavonoids from the Fissistigma tungfangense - Wan-Lin Zhong; Xue-Ming Zhou; Ji-Ling Yi; Xin-Ming Song; Bin Zhang; Jing-Yu Yang; Guang-Ying Chen (Natural Product Research, 2022)

EMS-CDNet: an efficient multi-scale-fusion change detection network for very high-resolution remote sensing images - Zhi Zheng; Yi Wan; Yongjun Zhang; Kun Yang; Rang Xiao; Chao Lin; Qiong Wu; Daifeng Peng (International Journal of Remote Sensing, 2022)

Metatranscriptomic analysis of host response and vaginal microbiome of patients with severe COVID-19 - Meng Xiao; Bo Lu; Rui Ding; Xia Liu; Xian Wu; Yaqian Li; Xudong Liu; Lin Qiu; Zhibo Zhang; Jing Xie; Yu Chen; Dong Zhang; et al. (Science China Life Sciences, 2022)

PPARγ Dysfunction in the Medial Prefrontal Cortex Mediates High-Fat Diet-Induced Depression - Cong-Cong Fu; Xin-Yi Zhang; Liu Xu; Hui-Xian Huang; Shuang Xu; Qiao-Qi Wu; Zhen Wang; Xi Gu; Li-Fang Lin; Song Lin; Ying-Ying Fang; Xiong Cao; et al. (Molecular Neurobiology, 2022)

Methionine restriction enhances the chemotherapeutic sensitivity of colorectal cancer stem cells by miR-320d/c-Myc axis - Chuan Liu; Jin-Liang Wang; Deng-Zhong Wu; Yi-Wu Yuan; Lin Xin (Molecular and Cellular Biochemistry, 2022)

Use of the MaxEnt model to predict changes in sloth bear (Melursus ursinus) habitats in the Gandaki River Basin, Nepal - Raju Rai; Yi-li Zhang; Zhao-feng Wang; Basanta Paudel; Lin-shan Liu; Mohan Kumar Rai; Narendra Raj Khanal (Journal of Mountain Science, 2022)

Testing the transfer functions for the Geonor T-200B and Chinese standard precipitation gauge in the central Qinghai—Tibet Plateau - Le-le Zhang; Li-ming Gao; Ji Chen; Lin Zhao; Ke-long Chen; Jing-yi Zhao; Guo-jun Liu; Ting-xi Song; Yan-kun Li (Journal of Mountain Science, 2022)

Influence of asymmetric blockage of the drainage system of a deep-buried tunnel on water gushing - He-lin Fu; Peng-tao An; Yi-min Wu; Jie Li; Long Chen (Journal of Mountain Science, 2022)

Aquapteridospora jiangxiensis, a new aquatic hyphomycetous fungus from a freshwater habitat in China - Su-Qin Peng; Yu-Lin Liu; Jun-En Huang; Xiao-Hong Li; Xin-Yi Yan; Hai-Yan Song; Yang Gao; Zhi-Jun Zhai; Yuan-Qiu Liu; Dian-Ming Hu (Archives of Microbiology, 2022)

Streptococcus vulneris sp. nov., isolated from wound of patient with diabetic foot ulcer (DFU) - Jen-hao Chung; Li-Ting Wang; Yi-Sheng Chen; Yun-Shien Lee; Shih-Ting Lin; Yu-Chung Chang; Hui-Chung Wu; Yu-Jie Dai; Wei-Qi Liao; Fan-Ching Kao; Jui-hsiang Li (Archives of Microbiology, 2022)

Electrospun Polysaccharides for Periodontal Tissue Engineering: A Review of Recent Advances and Future Perspectives - Jiao Wang; Yi Chen; Jialing Li; Zhen Chen; Min Fan; Fanjing Lin; Yonglin Xie (Annals of Biomedical Engineering, 2022)

Effects of dietary nucleotides on growth performance, immune response, intestinal morphology and disease resistance of juvenile largemouth bass, Micropterus salmoides - Xiao‐chun Chen; Xiao‐quan Huang; Yi‐wen Tang; Lei Zhang; Feng Lin (Journal of Fish Biology, 2022)
An 8 week feeding trial was carried out to investigate the effects of dietary nucleotides on growth performance, intestinal morphology, immune response and disease resistance of juvenile largemouth bass, Micropterus salmoides . Five grades of dietary nucleotide levels were designed as 0, 0.2, 0.4, 0.8 and 1.2 g kg −1 , respectively. Each group had 3 replicates, with 40 fish in each replicate. After the feeding experiment, 15 fish from each tank were infected with Aeromonas hydrophila for 14 days. The results indicated that fish fed the diets containing 0.4, 0.8 and 1.2 g kg −1 nucleotides had higher growth performance and feed utilization than those fed the control diet. Nonetheless, there were no significant differences in survival between all the groups, although fish fed the diets with all‐level nucleotides obtained higher survival than those fed the control diet. Dietary nucleotides significantly affected the superoxide dismutase, acid phosphatase and catalase activities in serum but not the malondialdehyde content. Fish fed the 0.4 g kg −1 nucleotide diets had the highest fold height, enterocyte height and muscular layer thickness significantly. The average mortality of largemouth bass infected with A. hydrophila was significantly influenced by dietary nucleotides. The mortality was significantly higher in the control group (91.11%) and 0.02% nucleotide group (73.11%) followed by the other groups and lowest in the 0.8 g kg −1 nucleotide group. In summary, dietary 0.4–0.8 g kg −1 nucleotides promoted growth performance, enhanced immunity and improved intestinal morphology and disease resistance of largemouth bass.

Discovery of the non‐cosmopolitan lineages in Candidatus Thermoprofundales - Yi‐Fan Liu; Liu Yang; Zhong‐Lin Liu; Jing Chen; Bo Fang; Lei Zhou; Jin‐Feng Liu; Shi‐Zhong Yang; Ji‐Dong Gu; Bo‐Zhong Mu (Environmental Microbiology, 2022)
Summary The recently proposed order Candidatus Thermoprofundales, currently containing only one family‐level lineage Marine Benthic Group‐D (MBG‐D), is distributed in global subsurface ecosystems and ecologically important, but its diversity, evolution and metabolism remain largely unknown. Here we described two novel family‐level specialized lineages in Ca . Thermoprofundales, JdFR‐43 and HyVt, which are restricted to specific biotopes (primarily in marine hydrothermal vents and occasionally in oil reservoirs and hot springs) in contrast to the cosmopolitan lineage MBG‐D. The comparative genomics revealed that the specialized lineages have streamlined genomes, higher GC contents, enriched genes associated with nucleotide biosynthesis, ribosome biogenesis and DNA repair and additional thermostable aminopeptidases, enabling them to adapt to high‐temperature habitats such as marine hydrothermal vents, deep subsurface oil reservoirs and hot springs. On the contrary, the unique metabolic traits of the cosmopolitan MBG‐D, motility, glycolysis, butanoate metabolism, secondary metabolites production and additional genes for specific peptides and carbohydrates degradation potentially enhance its response to environmental change. Substrate preference is found for most MAGs across all lineages with the ability to utilize both polysaccharides (chitin and starch) and proteinaceous substances, whereas JdFR‐43 members from oil reservoirs can only utilize proteins. These results expand the diversity of C a . Thermoprofundales significantly and further improve our understandings of the adaptations of C a . Thermoprofundales to various environments.

Estrogenic and anti-neutrophilic inflammatory phenanthrenes from Juncus effusus L. - Hao-Chun Hu; Yi-Hong Tsai; Yu-Che Chuang; Kuei-Hung Lai; Yu-Ming Hsu; Tsong-Long Hwang; Chih-Chan Lin; Ferenc Fülöp; Yang-Chang Wu; Szu-Yin Yu; Yu-Ting Kuo; Fang-Rong Chang (Natural Product Research, 2022)

Characterization of chemical constituents with their antioxidant and anti-melanogenesis activities from the roots of Ampelopsis japonica - Chia-Lin Lee; Yun-Lian Jhan; Hsiu-Mei Chiang; Yi-Hung Chen; Chao-Jung Chen; Yuan-Shiun Chang (Natural Product Research, 2022)

Recent progress in strategies for steroid production in yeasts - Yi-qi Jiang; Jian-ping Lin (World Journal of Microbiology and Biotechnology, 2022)

Perfusion Defects and Collateral Flow Patterns in Acute Small Subcortical Infarction: a 4D Dynamic MRI Study - Yen-Chu Huang; Jiann-Der Lee; Yi-Ting Pan; Hsu-Huei Weng; Jen-Tsung Yang; Leng-Chieh Lin; Yuan-Hsiung Tsai (Translational Stroke Research, 2022)
The hemodynamic changes of acute small subcortical infarction (SSI) are not well understood. We evaluate the hemodynamic changes and collaterals in acute SSI using perfusion magnetic resonance imaging (MRI). A total of 103 patients with acute SSI in penetrating artery territories were recruited and underwent MRI within 24 h of stroke onset. Using 4D dynamic perfusion MRI, they were divided into three patterns: 25 (24%) with normal perfusion, 31 (30%) with compensated perfusion, and 47 (46%) with hypoperfusion. The development of anterograde or retrograde collaterals was also evaluated. Patients with hypoperfusion pattern had the highest rate of early neurological deterioration (32%, p = 0.007), the largest initial and final infarction volumes ( p < 0.001 and p = 0.029), the lowest relative cerebral blood flow (0.63, p < 0.001), and the lowest rate of anterograde and retrograde collaterals (19%, p < 0.001; 66%, p = 0.002). The anterograde collaterals were associated with higher relative cerebral blood volume (0.91 vs. 0.77; p = 0.024) and a higher rate of deep cerebral microbleeds (48 vs. 21%; p = 0.028), whereas retrograde collaterals were associated with higher systolic and diastolic blood pressure ( p = 0.031 and 0.020), smaller initial infarction volume (0.81 vs. 1.34 ml, p = 0.031), and a higher rate of lobar cerebral microbleeds (30 vs. 0%; p = 0.013). Both anterograde and retrograde collaterals may play a critical role in maintaining cerebral perfusion and can have an impact on patient clinical outcomes. Further studies are warranted to verify these findings and to investigate effective treatments.

Cerebellar Oscillations in Familial and Sporadic Essential Tremor - Shi-Bing Wong; Yi-Mei Wang; Chih-Chun Lin; Scott Kun Geng; Nora Vanegas-Arroyave; Seth L. Pullman; Sheng-Han Kuo; Ming-Kai Pan (The Cerebellum, 2022)

Identification of the Largest SCA36 Pedigree in Asia: with Multimodel Neuroimaging Evaluation for the First Time - Yue Xie; Zhao Chen; Zhe Long; Rui-Ting Chen; Yi-Zheng Jiang; Ming-Jie Liu; Lin-Liu Peng; Hui-Rong Peng; Na Wan; Guangdong Zou; Chun-Rong Wang; Yu-Ting Shi; et al. (The Cerebellum, 2022)

Correction to: Publication characteristics, topic trends and knowledge domains of karst ecological restoration: a bibliometric and knowledge mapping analysis from 1991 to 2021 - Kehui Liu; Xiaojin Guan; Guangluan Li; Min Duan; Yi Li; Yanyan Hong; Meimei Lin; Rongxin Fu; Fangming Yu (Plant and Soil, 2022)

Publication characteristics, topic trends and knowledge domains of karst ecological restoration: a bibliometric and knowledge mapping analysis from 1991 to 2021 - Kehui Liu; Xiaojin Guan; Guangluan Li; Min Duan; Yi Li; Yanyan Hong; Meimei Lin; Rongxin Fu; Fangming Yu (Plant and Soil, 2022)

A Deep Mesencephalic Nucleus Circuit Regulates Licking Behavior - Di Zheng; Jia-Yu Fu; Meng-Yu Tang; Xiao-Dan Yu; Yi Zhu; Chen-Jie Shen; Chun-Yue Li; Shi-Ze Xie; Shan Lin; Minmin Luo; Xiao-Ming Li (Neuroscience Bulletin, 2022)

Association between MAP3K4 gene polymorphisms and the risk of schizophrenia susceptibility in a Northeast Chinese Han population - Yang Sun; Ye Lv; Hui-Wen Ren; Guan-Yu Wang; Li-Na Xuan; Yi-Yang Luo; Zhi-Lin Luan (Metabolic Brain Disease, 2022)

Dynamics of soil organic carbon in different-sized aggregates under splash erosion - Junqiu Lin; Nufang Fang; Yan Zhang; Yi Zeng; Daming Yang; Wei Dai; Ling Wang; Zhihua Shi (Journal of Soils and Sediments, 2022)

Evaluation of PET List Data-Driven Gated Motion Correction Technique Applied in Lung Tumors - Yi-Lun Chen; Bang-Hung Yang; I.-Ling Shih; Ko-Han Lin (Journal of Medical and Biological Engineering, 2022)

Use of piggyBac Transposon System Constructed Murine Breast Cancer Model for Reporter Gene Imaging and Characterization of Metastatic Tumor Cells - Ying-Ling Chen; Yung-Cheng Wang; Kuei-Yuan Hou; Min-Ying Lin; Yu-Chuan Lin; Hui-Yen Chuang; Yi-Jang Lee (Journal of Medical and Biological Engineering, 2022)

Detection of bloom-forming dinoflagellates Karenia mikimotoi and Prorocentrum donghaiense using qPCR assays - Xiao-Kun Hu; Zhuo-Ru Lin; Qing-Chun Zhang; Fan-Zhou Kong; Jing-Yi Cen; Yu-Lan Zeng; Ren-Cheng Yu (Journal of Applied Phycology, 2022)

Event-based landslide susceptibility models in Shihmen watershed, Taiwan: accounting for the characteristics of rainfall events - Chun-Yi Wu; Sheng-Yu Lin (Environmental Monitoring and Assessment, 2022)

Functional connectivity dynamics as a function of the fluctuation of tension during film watching - Yadi Sun; Junji Ma; Miner Huang; Yangyang Yi; Yiheng Wang; Yue Gu; Ying Lin; Liman Man Wai Li; Zhengjia Dai (Brain Imaging and Behavior, 2022)

Estrogen Deficiency Aggravates Fluoride-Induced Liver Damage and Lipid Metabolism Disorder in Rats - Ya-ming Yu; Bian-hua Zhou; Yi-lin Yang; Cheng-Xiang Guo; Jing Zhao; Hong-wei Wang (Biological Trace Element Research, 2022)

Flow-slide characteristics and failure mechanism of shallow landslides in granite residual soil under heavy rainfall - Hui-lin Bai; Wen-kai Feng; Shuang-quan Li; Long-zhen Ye; Zhong-teng Wu; Rui Hu; Hong-chuan Dai; Yun-peng Hu; Xiao-yu Yi; Peng-cheng Deng (Journal of Mountain Science, 2022)

Parallel Extraction of Marine Targets Applying OIDA Architecture - Lin Liu; Wanwu Li; Jixian Zhang; Yi Sun; Yumeng Cui (Journal of Ocean University of China, 2022)

Identification of Key Pathways and Genes in SARS-CoV-2 Infecting Human Intestines by Bioinformatics Analysis - Ji-Chun Chen; Tian-Ao Xie; Zhen-Zong Lin; Yi-Qing Li; Yu-Fei Xie; Zhong-Wei Li; Xu-Guang Guo (Biochemical Genetics, 2022)
COVID-19 is a serious infectious disease that has recently swept the world, and research on its causative virus, SARS-CoV-2, remains insufficient. Therefore, this study uses bioinformatics analysis techniques to explore the human digestive tract diseases that may be caused by SARS-CoV-2 infection. The gene expression profile data set, numbered GSE149312, is from the Gene Expression Omnibus (GEO) database and is divided into a 24-h group and a 60-h group. R software is used to analyze and screen out differentially expressed genes (DEGs) and then gene ontology (GO) term and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses are performed. In KEGG, the pathway of non-alcoholic fatty liver disease exists in both the 24-h group and 60-h group. STRING is used to establish a protein–protein interaction (PPI) network, and Cytoscape is then used to visualize the PPI and define the top 12 genes of the node as the hub genes. Through verification, nine statistically significant hub genes are identified: AKT1, TIMP1, NOTCH, CCNA2, RRM2, TTK, BUB1B, KIF20A, and PLK1. In conclusion, the results of this study can provide a certain direction and basis for follow-up studies of SARS-CoV-2 infection of the human digestive tract and provide new insights for the prevention and treatment of diseases caused by SARS-CoV-2.

Elastic-energy imaging condition based on energy-flow vector - Xiao-Yu Zhang; Yi Zheng; Chuan-Lin He; Zhan-Yuan Liang (Applied Geophysics, 2022)

Exploiting Sentinel-1 data and machine learning–based random forest for collectively mapping rice fields in Taiwan - Nguyen-Thanh Son; Chi-Farn Chen; Cheng-Ru Chen; Youg-Sin Cheng; Piero Toscano; Chein-Hui Syu; Horng-Yuh Guo; Shu-Ling Chen; Tsang-Sen Liu; Yi-Ting Zhang; Huan-Sheng Lin; Shih-Hsiang Chen; et al. (Applied Geomatics, 2022)

Distribution and invasion of Spartina alterniflora within the Jiaozhou Bay monitored by remote sensing image - Jianbu Wang; Zhaoyang Lin; Yuanqing Ma; Guangbo Ren; Zijun Xu; Xiukai Song; Yi Ma; Andong Wang; Yajie Zhao (Acta Oceanologica Sinica, 2022)

First report of chilli veinal mottle virus infecting tobacco in Guizhou, China - Yue Chen; Ting Ting Li; Jing Zhong; Li Ling Zhao; Ya Li Guo; Ye Chun Lin; Gui Gao; Yi Cao; Ming Ding (Journal of Plant Pathology, 2022)

Natural Feed Supplements Improve Growth, Non-Specific Immune Responses and Resistance against Vibrio alginolyticus in Lates calcarifer - Zhen-Hao Liao; Huai-Ting Huang; Yu-Ru Lin; Bo-Ying Chen; Yi-Fan Lee; Yuan-Heng Lin; Chieh-Yuan Chuang; Fan-Hua Nan (Journal of Marine Science and Engineering, 2022)
This study aimed to investigate the effects of dietary natural feed supplement on the growth performance, non-specific responses, and disease resistance in Lates calcarifer. Three commercial products (A, B, and C) containing a basal probiotic mixture were tested. Product A contained a basal mixture of Paenibacillus sp., Bacillus subtilis, Bacillus amyloliquefaciens, and Lactobacillus rhamnosus (107 cfu/g for each probiotic); product B contained additional Lactobacillus plantarum (1010 cfu/g); and product C contained additional soybean peptides (500 g/kg) and garlic powder (1 g/kg). Each product was supplemented into subject diets at dosages of 1 or 2 g/kg (designated as the A1, A2, B1, B2, C1, and C2 groups, respectively). Following an eight-week trial, growth parameters (specific growth rate and feed conversion ratio), non-specific immune responses (O2− production, phagocytic rate, and phagocytic index), and the results of a challenge test against Vibrio alginolyticus were evaluated. The results show that all probiotic supplement groups exhibited an improvement in growth performance compared to the control group (non-probiotic diet). In terms of non-specific immunity parameters, a significant improvement in O2− production was found in the C2 group, whereas significant improvements in phagocytic activity were found in all the B and C groups. The C2 group displayed optimal O2− production, phagocytic rate, and phagocytic index results. For the challenge test, the C groups showed higher Vibrio resistance than the other experimental groups and the control group. These results suggest that product C, given at dosages of 2 g/kg, may serve as a growth-promoting and immunostimulatory additive for the cultivation of Asian seabass.

Cracking and Photo-Oxidation of Polyoxymethylene Degraded in Terrestrial and Simulated Marine Environments - Chih-Cheng Tang; Ying-Ting Chen; Yi-Ming Zhang; Huey-Ing Chen; Peter Brimblecombe; Chon-Lin Lee (Frontiers in Marine Science, 2022)
Marine plastic debris is an environmental problem, and its degradation into microplastics (1-5000 μm) introduces them into the food chain. In this study, small polyoxymethylene (global production ~3000 Tg per year) pellets were exposed in terrestrial and simulated marine environments to heat and light, resulting in cracking during decay with increasing IR absorption (OH-bonds). Furthermore, sunlight over three years reduced pellet mass and diameter (~10% and ~40%), initially yielding 100-300 μm fragments. Changes under UV irradiation were smaller as it could not penetrate into particle interiors. Characteristic spacing of surface striations (100-300 µm) initiated radial cracks to pellet interiors, and breakdown ultimately meant 95% of particles were <300 µm, which are potentially incorporated in marine turbidites.

Effects of Involuntary and Voluntary Exercise in Combination with Acousto-Optic Stimulation on Adult Neurogenesis in an Alzheimer's Mouse Model - Wan-yi Li; Jun-yan Gao; Su-Yang Lin; Shao-tao Pan; Biao Xiao; Yu-tao Ma; Kai Xie; Wei Shen; Zhi-tao Liu; Guang-yu Li; Jie-jie Guo; Qin-wen Wang; et al. (Molecular Neurobiology, 2022)

Post-failure evolution analysis of an irrigation-induced loess landslide using multiple remote sensing approaches integrated with time-lapse ERT imaging: lessons from Heifangtai, China - Shiqiang Bian; Guan Chen; Runqiang Zeng; Xingmin Meng; Jiacheng Jin; Linxin Lin; Yi Zhang; Wei Shi (Landslides, 2022)

Photosynthesis-Related Proteins Play Crucial Role During Senescence Stage in Flue-Cured Tobacco Plants: A Combine iTRAQ-PRM Study - Conglian He; Shubin Sun; Yun Tang; Chenggang He; Pengfei Li; Tianyang Xu; Gaokun Zhao; Congming Zou; Zhonglong Lin; Yi Chen (Journal of Plant Growth Regulation, 2022)

Community structure and assembly of denitrifying bacteria in epiphytic biofilms in a freshwater lake ecosystem - Guoqing Li; Dingbo Yan; Pinhua Xia; Haipeng Cao; Tao Lin; Yin Yi (Journal of Oceanology and Limnology, 2022)

Identification of PDXDC1 as a novel pleiotropic susceptibility locus shared between lumbar spine bone mineral density and birth weight - Yu-Qian Song; Shi-Di Hu; Xu Lin; Xiang-He Meng; Xiao Wang; Yin-Hua Zhang; Cheng Peng; Rui Gong; Tao Xu; Tong Zhang; Chen-Zhong Li; Dao-Yan Pan; et al. (Journal of Molecular Medicine, 2022)
An increasing number of epidemiological studies have suggested that birth weight (BW) may be a determinant of bone health later in life, although the underlying genetic mechanism remains unclear. Here, we applied a pleiotropic conditional false discovery rate (cFDR) approach to the genome-wide association study (GWAS) summary statistics for lumbar spine bone mineral density (LS BMD) and BW, aiming to identify novel susceptibility variants shared between these two traits. We detected 5 novel potential pleiotropic loci which are located at or near 7 different genes ( NTAN1 , PDXDC1 , CACNA1G , JAG1 , FAT1P1 , CCDC170 , ESR1 ), among which PDXDC1 and FAT1P1 have not previously been linked to these phenotypes. To partially validate the findings, we demonstrated that the expression of PDXDC1 was dramatically reduced in ovariectomized (OVX) mice in comparison with sham-operated (SHAM) mice in both the growth plate and trabecula bone. Furthermore, immunohistochemistry assay with serial sections showed that both osteoclasts and osteoblasts express PDXDC1 , supporting its potential role in bone metabolism. In conclusion, our study provides insights into some shared genetic mechanisms for BMD and BW as well as a novel potential therapeutic target for the prevention of OP in the early stages of the disease development. Key messages We investigated pleiotropy-informed enrichment between LS BMD and BW. We identified genetic variants related to both LS BMD and BW by utilizing a cFDR approach. PDXDC1 is a novel pleiotropic gene which may be related to both LS BMD and BW. Elevated expression of PDXDC1 is related to higher BMD and lower ratio n-6/n-3 PUFA indicating a bone protective effect of PDXDC1.

X-ray Irradiation Improves Neurological Function Recovery of Injured Spinal Cord by Inhibiting Inflammation and Glial Scar Formation - Yi Wang; Yanping Niu; Fanguo Lin; Peng Su; Liesong Chen; Dong Liu; Yongming Sun (Journal of Molecular Neuroscience, 2022)

Links between continental subduction and generation of Cenozoic potassic–ultrapotassic rocks revealed by olivine oxygen isotopes: A case study from NW Tibet - Gong-Jian Tang; Derek A. Wyman; Qiang Wang; Lin Ma; Wei Dan; Ya-Nan Yang; Xi-Jun Liu; Hong-Yi Chen (Contributions to Mineralogy and Petrology, 2022)

Deformation characteristics and thresholds of the Tanjiawan landslide in the Three Gorges Reservoir Area, China - Fu-ling Zhang; Mao-lin Deng; Qing-lin Yi; Shu-qiang Lu; Wei-jun Zheng; Hai-feng Huang; Xing Zhu (Journal of Mountain Science, 2022)

Analysis of the influence of reinforcement material type on bearing and deformation characteristics of reinforced earth retaining wall - Jia-Quan Wang; Sen-Lei Hou; Zhi-Nan Lin; Yi Tang (Arabian Journal of Geosciences, 2022)

Evolutionary and ecological patterns of scatter‐ and larder‐hoarding behaviours in rodents - Yongjun Zhang; Fei Yu; Xianfeng Yi; Weiwei Zhou; Rui Liu; Marcel Holyoak; Lin Cao; Mingming Zhang; Jiani Chen; Zhibin Zhang; Chuan Yan (Ecology Letters, 2022)
Scatter‐ and larder hoarding are the primary strategies of food‐hoarding animals and have important implications for plant‐animal interactions and plant recruitment. However, their origins and influencing factors have not been fully investigated across a wide range of taxa. Our systematic literature search amassed data for 183 seed‐hoarding rodent species worldwide and tested relationships of seed‐hoarding behaviours with phylogenetic signal, functional traits and environmental factors. We found that the evolution of hoarding strategies was not random in phylogeny, and scatter hoarding originated independently multiple times from larder hoarding. Rodents with higher encephalisation quotient (relative brain size), omnivorous diet (related to dependence on seeds) and inhabiting lower latitudes were disproportionately likely to scatter hoard. Despite body mass’s potential relationship with competition through food defence, it was associated with food‐hoarding strategy only in a few families. Our results show the need to study the community and ecological context of food‐hoarding behaviours.

Composition, Demographic History, and Population Structures of Trichiurus - Kui-Ching Hsu; Mu-Rong Yi; Sui Gu; Xiong-Bo He; Zhi-Sen Luo; Bin Kang; Hung-Du Lin; Yun-Rong Yan (Frontiers in Marine Science, 2022)
Sequences of the complete mitochondrial cytochrome oxidase subunit I gene were used to identify Trichiurus species and examine their population genetic structure and demographic history along the coast of China. Three Trichiurus species were found. Trichiurus japonicus lives in colder waters along the continental shelves in the China Seas, while Trichiurus nanhaiensis lives warmer waters along continental slopes in the South China Sea, and Trichiurus brevis lives in shallow and warmer waters in the South China Sea. The migrations of these species were mainly associated with feeding and spawning preferences. Two major wintering and spawning grounds in the East China Sea and South China Sea were found. All species showed a lack of population genetic structure resulting from their oceanodromous life cycle (the degree of population substructure index N ST = 0.000–0.149), but the results of approximate Bayesian computational approaches suggested population declines or stabilization and differentiation. The results of the T MRCA (time to the most recent common ancestor) showed that during glaciations, the Yellow Sea and the East China Sea were completely exposed, and the South China Sea acted as a refugium. Thus, the populations of these three species experienced differentiation during glaciations. This study also examined the limitations of Bayesian skyline plot analysis.

Natural Convection Induced by Diurnal Heating and Cooling over a Fully Vegetated Slope - Xiaosheng Ji; Yi-Qi Ye; Bo Wang; Ying-Tien Lin (Journal of Marine Science and Engineering, 2022)
In this study, by assuming a small bottom slope, asymptotic solutions were developed to discuss natural convection within rooted emergent vegetation in response to different heating and cooling mechanisms. Based upon the maximum water depth in comparison to the penetration depth of solar radiation, two scenarios in shallow and deep waters were examined. The temperature structures showed that isotherms in shallows are near vertical but become stable stratified layers (horizontal isotherms) in deep regions. In shallow regions, horizontal velocity profiles perform classic cubic shapes, while the horizontal velocity in deep regions is constant near the surface, and a local upslope flow occurs near the bottom. In shallow water, viscous effects are dominant to shape the velocity profiles, whereas vegetation drag becomes more important in deep regions. By using turbulent parameters, horizontal exchange flowrates and velocities predicted by the asymptotic solutions show good agreements with the existing measurements.

Genetic Diversity Analysis of Sugarcane (Saccharum spp. hybrids) Among High-Sucrose Clones of GT Series and Commonly Used Parents by Using Microsatellite Markers in Guangxi, China - Hai-Rong Huang; Yi-Jing Gao; Mukesh Kumar Malviya; Krishan K. Verma; Manoj Kumar Solanki; Yu-Xin Huang; Xiang Li; Yuchi Deng; Jing Yan; Shi-Yun Tang; Lun-Wang Wang; Lin Xu (Sugar Tech, 2022)

TRIP13 knockdown inhibits the proliferation, migration, invasion, and promotes apoptosis by suppressing PI3K/AKT signaling pathway in U2OS cells - De-Chen Yu; Xiang-Yi Chen; Hai-Yu Zhou; De-Quan Yu; Xiao-Lei Yu; Yi-Cun Hu; Rui-Hao Zhang; Xiao-Bo Zhang; Kun Zhang; Mao-Qiang Lin; Xi-Dan Gao; Tao-Wen Guo (Molecular Biology Reports, 2022)

Stability Analysis of Slope Considering the Energy Evolution of Locked Segment - Xiangjie Yin; Hang Lin; Yifan Chen; Yi Tang; Yixian Wang; Yanlin Zhao; Weixun Yong (Geotechnical and Geological Engineering, 2022)

Genetic diversity and population structure of Curcuma alismatifolia Gagnep. accessions revealed by SSR markers - Hui-Wen Yu; Ling-Jun Ke; Yi-Lan Xiao; Si-Jia Chen; Yuan-Yuan Li; Qi-Lin Tian; Yun-He Li; Jin-Shui Lin; Luan-Mei Lu (Genetic Resources and Crop Evolution, 2022)

Pollution characteristics and emissions of typical organophosphate esters of a wastewater treatment plant - Hongling Yin; Yi Luo; Jiaojiao Song; Shiping Li; Shuyu Lin; Yuanming Xiong; Shuhong Fang; Juan Tang (Environmental Science and Pollution Research, 2022)

Component-level embodied carbon database for landscape hard works in Taiwan - Hsien-Te Lin; Yi-Jiung Lin (Environment, Development and Sustainability, 2022)

Probiotics and their Metabolites Reduce Oxidative Stress in Middle-Aged Mice - Wen-Yang Lin; Jia-Hung Lin; Yi-Wei Kuo; Pei-Fang Rose Chiang; Hsieh-Hsun Ho (Current Microbiology, 2022)
Aging is an irreversible physiological degradation of living organisms. Accumulated oxidative stress and dysbiosis accelerate aging. Probiotics such as Lactobacillus and Bifidobacterium and their fermented metabolites (postbiotics) have been discovered to exhibit antioxidative activities that regulate oxidative stress and protect cells from oxidative damage. We screened selected Lactobacillus and Bifidobacterium strains and their postbiotics for potential antioxidative activity by using DPPH (2,2-Diphenyl-1-picrylhydrazyl) assay. Strains with their metabolites were selected for mixed formula in experiments involving aging mice. The aged groups presented higher oxidative stress in the brain, liver, heart, and kidney than did young mice. However, treatment with probiotic strains and their postbiotics elevated antioxidative levels, especially in the high-dose probiotics plus postbiotics group. Next-generation sequencing data revealed positive microbiota alterations of Lactobacillus and Bifidobacterium and Akkermansia in the gut. Lactobacillus johnsonii and Akkermansia muciniphila exhibited effective enlargement of relative abundance. Besides, high-dose probiotics and high-dose probiotics plus postbiotics showed significant elevation in serum SCFAs, especially in butyrate. In conclusion, the formula containing Bifidobacterium animalis subsp. infantis BLI-02, Bifidobacterium breve Bv889, Bifidobacterium bifidum VDD088, B. animalis subsp. lactis CP-9, and Lactobacillus plantarum PL-02 and their metabolites may benefit aged people’s health.

Production of sesquiterpene patchoulol in mitochondrion-engineered Saccharomyces cerevisiae - Xin-Yi Tao; Yang-Chen Lin; Feng-Qing Wang; Qing-Hai Liu; Yu-Shu Ma; Min Liu; Dong-Zhi Wei (Biotechnology Letters, 2022)

Road performance and microscopic action mechanism of low liquid limit silt solidified by AT curing agent - Jin Chang; Jian-Qing Jiang; Ming Lei; Shi-Lin Luo; Guang-Feng He; Jia-Yi Lin (Arabian Journal of Geosciences, 2022)

The significance of riparian communities in the energy flow of subtropical stream ecosystems - Yi-Chang Liao; An-Cheng Lin; Han-Ni Tsai; Yu-Ting Yen; Chyng-Shyan Tzeng; Man-Miao Yang; Hsing-Juh Lin (Aquatic Sciences, 2022)

One-Way Intestinal Perfusion of PVP/VA–Poloxamer 188–Curcuma longa L. Extract Solid Dispersion in Rats In Vivo and Its Effect on HSC–T6 Cell Proliferation - Jie Gao; Yi Shi; Yunfeng Han; Xi Tang; Ruohong Bi; Lin Pan; Xianrong Lai (AAPS PharmSciTech, 2022)

Effect of High-Pressure Treatment on Blue Marlin ( Makaira nigricans ) Quality During Storage - Yi-Chen Lee; Hsien-Feng Kung; Shao-Lan Chen; Chung-Saint Lin; Chun-Yung Huang; Osamu Arakawa; Chih-Hua Tseng; Yung-Hsiang Tsai (Journal of Aquatic Food Product Technology, 2022)

Sterols and triterpenoids from Ganoderma lucidum and their reversal activities of tumor multidrug resistance - Min Wu; Cui-e Shen; Qiao-fa Lin; Jin-yi Zhong; Yan-fei Zhou; Ben-chen Liu; Jian-hua Xu; Zhi-qiang Zhang; Peng Li (Natural Product Research, 2022)

Mapping spatial-temporal nationwide soybean planting area in Argentina using Google Earth Engine - Yulin Shangguan; Xiyu Li; Yi Lin; Jinsong Deng; Le Yu (International Journal of Remote Sensing, 2022)

Octahedral silver oxide nanoparticles enabling remarkable SERS activity for detecting circulating tumor cells - Meng He; Jie Lin; Ozioma Udochukwu Akakuru; Xiawei Xu; Yanying Li; Yi Cao; Yanping Xu; Aiguo Wu (Science China Life Sciences, 2022)

Associations of CXCL12 polymorphisms with clinicopathological features in breast cancer: a case-control study - Shuai Lin; Yi Zheng; Meng Wang; Linghui Zhou; Yuyao Zhu; Yujiao Deng; Ying Wu; Dai Zhang; Na Li; Huafeng Kang; Zhijun Dai (Molecular Biology Reports, 2022)
Background Previous studies suggested that CXCL12 was involved in the development, metastasis, and invasion of breast cancer, and genetic variants were associated with the diagnosis and prognosis of patients with breast cancer. The present study was aimed to assess the relationships between CXCL12 polymorphisms (rs1801157, rs2297630, and rs2839693) and susceptibility and clinicopathological features of breast cancer. Methods A case-control study was conducted in 434 breast cancer patients and 450 health controls. Student t -test and chi-square test were used to analyze the differences of age distribution and genotype frequencies between the two groups. Correlations between polymorphisms and clinical parameters were also assessed by chi-square test. The potential effects of the three polymorphisms on CXCL12 were investigated by the public database. Results A statistical association was found between CXCL12 rs1801157 polymorphism and breast cancer risk, possibility of metastasis, and estrogen receptor status. Patients with rs2839693 C/T or C/T-T/T genotypes were more likely to be progesterone receptor-negative. However, no associations of rs2297630 polymorphism with breast cancer risk or any clinicopathological characteristics were observed. In addition, rs2297630 affected the splicing quantitative trait loci of CXCL12 in the subcutaneous fat, rs2839693 polymorphism affected the splicing quantitative trait loci of CXCL12 in the human breast mammary tissues. Conclusions Those results indicated that CXCL12 polymorphisms might be potential diagnostic indicators, and more investigation is needed in the future.

Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated Encephalopathy by Promoting Ferroptosis Through Regulating miR-9-5p/TFRC and GOT1 Axis - Xue-biao Wei; Wen-qiang Jiang; Ju-hao Zeng; Lin-qiang Huang; Hong-guang Ding; Yuan-wen Jing; Yong-li Han; Yi-chen Li; Sheng-long Chen (Molecular Neurobiology, 2022)
Sepsis can cause sepsis-associated encephalopathy (SAE), but whether SAE was induced or exacerbated by ferroptosis remains unknown. In this study, the rat sepsis model was constructed using the cecal ligation and puncture method. The blood–brain barrier (BBB) permeability was measured by Evans blue dye (EBD) in vivo. The levels of ROS, Fe ion, MDA, GSH, and GPX4 were assessed by enzyme-linked immunosorbent assay (ELISA). The exosomes isolated from serum were cultured with bEnd.3 cells for the in vitro analysis. Moreover, bEnd.3 cells cultured with 100 μM FeCl3 (iron-rich) were to simulate ferroptosis stress. The cell viability was evaluated by Cell Counting Kit-8 (CCK-8) assay. A dual-luciferase reporter gene assay was performed to confirm the relationship between miR-9-5p with NEAT1, TFRC , and GOT1 . In vivo, it is found that BBB permeability was damaged in model rats. Level of ROS, Fe ion, and MDA was increased, and level of GSH and GPX4 was decreased, which means ferroptosis was induced by sepsis. Exosome-packaged NEAT1 in serum was significantly upregulated in model rats. In vitro, it is found that NEAT1 functions as a ceRNA for miR-9-5p to facilitate TFRC and GOT1 expression. Overexpression of NEAT1 enhanced ferroptosis stress in bEnd.3 cells. Increased miR-9-5p alleviated sepsis-induced ferroptosis by suppressing the expression of TFRC and GOT1 both in vivo and in vitro. In conclusion, these findings suggest that sepsis induced high expression of serous exosome-derived NEAT1, and it might exacerbate SAE by promoting ferroptosis through regulating miR-9-5p/ TFRC and GOT1 axis.

Identification of epigenetic modifications mediating the antagonistic effect of selenium against cadmium-induced breast carcinogenesis - Zhuo-Zhi Liang; Yi-Xin Zhang; Rui-Mei Zhu; Yue-Lin Li; Hong-Mei Jiang; Ruo-Bi Li; Qian-Xin Chen; Qing Wang; Lu-Ying Tang; Ze-Fang Ren (Environmental Science and Pollution Research, 2022)

Characteristics of antibiotic resistance genes in full-scale anaerobic digesters of food waste and the effects of application of biogas slurry on soil antibiotic resistance genes - Pan Wang; Yi Zheng; Peiru Lin; Xiteng Chen; Linsong Qi; Xinyu Yang; Lianhai Ren (Environmental Science and Pollution Research, 2022)

An input–output structural decomposition analysis of changes in China’s renewable energy consumption - Xinyue Lin; Haoran Pan; Lingli Qi; Yi-Shuai Ren; Basil Sharp; Chaoqun Ma (Environmental Science and Pollution Research, 2022)

Very Low Stocks and Inputs of Necromass in Wind-affected Tropical Forests - Kuo-Jung Chao; Pin-Siou Liao; Yi-Sheng Chen; Guo-Zhang Michael Song; Oliver L. Phillips; Hsing-Juh Lin (Ecosystems, 2022)

Description of Aureibaculum luteum sp. nov. and Aureibaculum flavum sp. nov. isolated from Antarctic intertidal sediments - Xiao-yan He; Ning-hua Liu; Chao-yi Lin; Mei-ling Sun; Xiu-lan Chen; Yu-zhong Zhang; Yu-qiang Zhang; Xi-ying Zhang (Antonie van Leeuwenhoek, 2022)

MoOpy2 is essential for fungal development, pathogenicity, and autophagy in Magnaporthe oryzae - Ying‐Ying Cai; Jing‐Yi Wang; Xi‐Yu Wu; Shuang Liang; Xue‐Ming Zhu; Lin Li; Jian‐Ping Lu; Xiao‐Hong Liu; Fu‐Cheng Lin (Environmental Microbiology, 2022)
Summary The development and pathogenicity of the fungus Magnaporthe oryzae , the causal agent of destructive rice blast disease, require it to perceive external environmental signals. Opy2, an overproduction‐induced pheromone‐resistant protein 2, is a crucial protein for sensing external signals in Saccharomyces cerevisiae . However, the biological functions of the homologue of Opy2 in M. oryzae are unclear. In this study, we identified that MoOPY2 is involved in fungal development, pathogenicity, and autophagy in M. oryzae . Deletion of MoOPY2 resulted in pleiotropic defects in hyphal growth, conidiation, germ tube extension, appressorium formation, appressorium turgor generation, and invasive growth, therefore leading to attenuated pathogenicity. Furthermore, MoOpy2 participates in the Osm1 MAPK pathway and the Mps1 MAPK pathway by interacting with the adaptor protein Mst50. The interaction sites of Mst50 and MoOpy2 colocalized with the autophagic marker protein MoAtg8 in the preautophagosomal structure sites (PAS). Notably, the Δ Moopy2 mutant caused cumulative MoAtg8 lipidation and rapid GFP‐MoAtg8 degradation in response to nitrogen starvation, showing that MoOpy2 is involved in the negative regulation of autophagy activity. Taken together, our study revealed that MoOpy2 of M. oryzae plays an essential role in the orchestration of fungal development, appressorium penetration, autophagy and pathogenesis.

Propagation and Separation of Downslope Gravity Currents over Rigid and Emergent Vegetation Patches in Linearly Stratified Environments - Ying-Tien Lin; Yi-Qi Ye; Dong-Rui Han; Yu-Jia Chiu (Journal of Marine Science and Engineering, 2022)
Large eddy simulation (combined with the mixture model) and laboratory experiment were used to investigate the impact of emergent and rigid vegetation on the dynamics of downslope gravity currents in stratified environments. The reliability of the numerical model was assessed with the corresponding laboratory measurements. The results show that the vegetation cylinders lead to severe lateral non-uniformity of the current front, causing more evident lobe and cleft structures. In stratified environments, the smaller driving force leads to less propagating velocity until the current separates from the slope. The transition point (from acceleration to deceleration phases) of current velocity appears earlier as the vegetation becomes denser. The peak value of the bulk entrainment coefficient Ebuik is inversely proportional to the vegetation density, while the final converged value of Ebuik is proportional to the vegetation density. Vegetation patches make the degree of fluctuation of the instantaneous entrainment coefficient Einst more intense, and even negative values appear locally, indicating that the gravity current is detrained into the ambient fluid. The velocity profiles of gravity current develop multi-peak patterns in stratified environments due to fingering intrusive patterns. Our analysis reveals that as the vegetation density increases, the generated wakes behind vegetation cylinders increase local entrainment and mixing, causing the density of current flow from vegetation to decrease and reach the neutral buoyancy layer of ambient fluids earlier, finally leading to a smaller separation depth.

Global estimation of clear-sky shortwave aerosol direct radiative effects based on CALIPSO observations - Zhenwei Shi; Zhaoxu Zhang; Wei Chen; Yi Lin (International Journal of Remote Sensing, 2022)

L-Theanine Ameliorated Rotenone-Induced Parkinsonism-like Symptoms in Rats - Cheng-Neng Chen; Mao-Hsien Wang; Hung-Sheng Soung; Shu-Mei Chen; Chih-Hsiang Fang; Yi-Wen Lin; Hsiang-Chien Tseng (Neurotoxicity Research, 2022)

Common Subtype of Small Renal Mass MR Imaging Characterisation: A Medical Center Experience in Taiwan - Ming-Cheng Liu; Yi-Jui Liu; Yen-Ting Lin; Siu-Wan Hung; Jyh-Wen Chai; Si-Wa Chan; Kun-Yuan Chiu; Ya-Ling Tsou (Journal of Medical and Biological Engineering, 2022)
Purpose Many studies have shown that multiparametric magnetic resonance imaging (MRI) may be helpful for differentiating malignant renal cell carcinomas (RCCs) from benign lesions. However, the key imaging characteristics that differ between malignant and benign tumors still require further discussion. Methods We analyzed 60 adult patients diagnosed with 72 small renal masses (SRMs) who received preoperative MRI from 2014 to 2019 at a hospital in Taiwan. The MRI features included conventional MRI parameters, diffusion-weighted imaging (DWI) data, and dynamic contrast-enhanced (DCE) patterns, which were documented and compared among the four common subtypes: clear cell RCC (ccRCC), papillary RCC (pRCC), angiomyolipoma (AML) and other types of RCC. The apparent diffusion coefficient (ADC) values of high- and low-grade RCCs were also analyzed. Results The results show that ccRCC had higher T2-weighted signal intensity than the other three subgroups, a higher arterial wash-in index (AWI) and ADC value than AML and pRCC, and manifested a plateau ( n = 9, 25%) or washout (n = 27, 75%) enhancement pattern. AMLs exhibited more intravoxel fat than the other three subtype groups, and half of the AMLs (6 in 12) contained bulk fat. pRCC demonstrated a more progressive (n = 3, 60%) enhancement pattern than the other three subgroups. The ADC value of high-grade RCCs was significantly lower than that of low-grade RCCs. Conclusion These findings may indicate that multiparametric MRI is useful in differentiating among four common pathological types of SRMs, and the ADC value may be helpful in evaluating the histological grade of malignancy.

Dissipation and residue of fosthiazate in tomato and cherry tomato and a risk assessment of dietary intake - Sukun Lin; Yi Zhou; Jiyingzi Wu; Zhixiang Zhang; Dongmei Cheng (Environmental Science and Pollution Research, 2022)

Identifying the priority areas for enhancing the ecosystem services in hilly and mountainous areas of southern China - Jia-ling Tian; Yu Peng; Yi-hang Huang; Ting Bai; Lian-lin Liu; Xiao-ao He; Shi-qian Luo (Journal of Mountain Science, 2022)

Optimal array layout of cylindrical baffles to reduce energy of rock avalanche - Yu-zhang Bi; Dong-po Wang; Xian-lei Fu; Yi-xiong Lin; Xin-po Sun; Zhe-yuan Jiang (Journal of Mountain Science, 2022)

Climate warming promotes deterministic assembly of arbuscular mycorrhizal fungal communities - Xinyu Xu; Yunpeng Qiu; Kangcheng Zhang; Fei Yang; Mengfei Chen; Xi Luo; Xuebin Yan; Peng Wang; Yi Zhang; Huaihai Chen; Hui Guo; Lin Jiang; et al. (Global Change Biology, 2022)
Arbuscular mycorrhizal fungi (AMF) significantly contribute to plant resource acquisition and play important roles in mediating plant interactions and soil carbon (C) dynamics. However, it remains unclear how AMF communities respond to climate change. We assessed impacts of warming and precipitation alterations (30% increase or decrease) on soil AMF communities, and examined major ecological processes shaping the AMF community assemblage in a Tibetan alpine meadow. Our results showed that warming significantly increased root biomass, and available nitrogen (N) and phosphorus (P) in soil. While precipitation alterations increased AMF abundances, they did not significantly affect the composition or diversity of AMF communities. In contrast, warming altered the composition of AMF communities and reduced their Shannon–Wiener index and Pielou's evenness. In particular, warming shifted the AMF community composition in favor of Diversisporaceae over Glomeraceae, likely through its impact on soil N and P availability. In addition, AMF communities were phylogenetically random in the unwarmed control but clustered in warming plots, implying more deterministic community assembly under climate warming. Warming enhancement of root growth, N and P availability likely reduced plant C‐allocation to AMF, imposing stronger environmental filtering on AMF communities. We further proposed a conceptual framework that integrates biological and geochemical processes into a mechanistic understanding of warming and precipitation changes’ effects on AMF. Taken together, these results suggest that soil AMF communities may be more sensitive to warming than expected, highlighting the need to monitor their community structure and associated functional consequences on plant communities and soil C dynamics under the future warmer climate.