Identification of the Largest SCA36 Pedigree in Asia: with Multimodel Neuroimaging Evaluation for the First Time - Yue Xie; Zhao Chen; Zhe Long; Rui-Ting Chen; Yi-Zheng Jiang; Ming-Jie Liu; Lin-Liu Peng; Hui-Rong Peng; Na Wan; Guangdong Zou; Chun-Rong Wang; Yu-Ting Shi; et al. (The Cerebellum, 2022)

Chaperone-mediated Autophagy Regulates Cell Growth by Targeting SMAD3 in Glioma - Hanqun Liu; Yuxuan Yong; Xingjian Li; Panghai Ye; Kai Tao; Guoyou Peng; Mingshu Mo; Wenyuan Guo; Xiang Chen; Yangfu Luo; Yuwan Lin; Jiewen Qiu; et al. (Neuroscience Bulletin, 2022)

Detection of bloom-forming dinoflagellates Karenia mikimotoi and Prorocentrum donghaiense using qPCR assays - Xiao-Kun Hu; Zhuo-Ru Lin; Qing-Chun Zhang; Fan-Zhou Kong; Jing-Yi Cen; Yu-Lan Zeng; Ren-Cheng Yu (Journal of Applied Phycology, 2022)

Efficient removal of pefloxacin from aqueous solution by acid–alkali modified sludge-based biochar: adsorption kinetics, isotherm, thermodynamics, and mechanism - Hongli Huang; Yongxin Zheng; Dongning Wei; Guang Yang; Xin Peng; Lingjia Fan; Lin Luo; Yaoyu Zhou (Environmental Science and Pollution Research, 2022)

Heavy metal-induced lipogenic gene aberration, lipid dysregulation and obesogenic effect: a review - Yang Zhou; Frank Peprah Addai; Xinshuang Zhang; Yuelin Liu; Yinfeng Wang; Feng Lin; Alex Tuffour; Jie Gu; Guangxiang Liu; Haifeng Shi (Environmental Chemistry Letters, 2022)

Successful treatment of acute-on-chronic liver failure secondary to alcoholic cirrhosis with glucocorticoids and albumin: a case report - Jiuqin Zhou; Si Chen; Lin Zhang; Yongzhen Zhai (DARU Journal of Pharmaceutical Sciences, 2022)

Preliminary study of genome-wide association identifies novel susceptibility genes for serum mineral elements in the Chinese Han population - Duojian Guo; Yu Zhou; Xingwei Wei; Shanshan Zhang; Tianbo Jin; Yutian Zhang; Mei Lin; Xiaoli Zhou; Yufei Xie; Chanyi He; Qi Lin; Ping He; et al. (Biological Trace Element Research, 2022)

Estrogen Deficiency Aggravates Fluoride-Induced Liver Damage and Lipid Metabolism Disorder in Rats - Ya-ming Yu; Bian-hua Zhou; Yi-lin Yang; Cheng-Xiang Guo; Jing Zhao; Hong-wei Wang (Biological Trace Element Research, 2022)

Present-Day PM2.5 over Asia: Simulation and Uncertainty in CMIP6 ESMs - Xiaole Su; Tongwen Wu; Jie Zhang; Yong Zhang; Junli Jin; Qing Zhou; Fang Zhang; Yiming Liu; Yumeng Zhou; Lin Zhang; Steven T. Turnock; Kalli Furtado (Journal of Meteorological Research, 2022)

SmGDB: genome database of Salvia miltiorrhiza, an important TCM Plant - Changhao Zhou; Caicai Lin; Piyi Xing; Xingfeng Li; Zhenqiao Song (Genes & Genomics, 2022)

Comparison of different inversion methods of D-T2 two-dimensional nuclear magnetic resonance logging and applicability analysis - Cheng-Lin Li; Mao-Jin Tan; Ke-Wen Wang; Feng Zhou; Ying-Ming Liu; Hai-Tao Zhang; Li-Zhi Xiao (Applied Geophysics, 2022)

Functional differentiation and complementation of alkaline phosphatases and choreography of DOP scavenging in a marine diatom - Kaidian Zhang; Jiashun Li; Jierui Wang; Xin Lin; Ling Li; Yanchun You; Xiaomei Wu; Zhi Zhou; Senjie Lin (Molecular Ecology, 2022)
Facing phosphate deficiency, phytoplankton use alkaline phosphatase (AP) to scavenge dissolved organophosphate (DOP). AP is a multitype (e.g., PhoA, PhoD) family of hydrolases and is known as a promiscuous enzyme with broad DOP substrate compatibility. Yet, whether the multiple types differentiate on substrates and collaborate to provide physiological flexibility remain elusive. Here we identify PhoA and PhoDs and document the functional differentiation between PhoA and a PhoD (PhoD_45757) in Phaeodactylum tricornutum . CRISPR/Cas9‐based mutations and physiological analyses reveal that (1) PhoA is a secreted enzyme and contributes the majority of total AP activity whereas PhoD_45757 is intracellular and contributes a minor fraction of the total AP activity, (2) AP gene expression compensates for each other after one is disrupted, (3) the DOP→PhoA→phosphate_uptake and the DOP_uptake→PhoD→phosphate pathways function interchangeably for some DOP substrates. These findings shed light on the underpinning of AP’s multiformity and have important implications in phytoplankton phosphorus‐nutrient niche differentiation, physiological plasticity, and competitive strategy.

Optimization of aquaculture sustainability through ecological intensification in China - Shuang‐lin Dong; Yun‐wei Dong; Ling Cao; Johan Verreth; Yngvar Olsen; Wen‐jing Liu; Qi‐zhi Fang; Yan‐gen Zhou; Li Li; Jing‐yu Li; Yong‐tong Mu; Patrick Sorgeloos (Reviews in Aquaculture, 2022)
As the world's leading producer of farmed aquatic food products, China faces great uncertainty concerning the further sustainable development of its aquaculture industry due to high and increasing pressure from environmental and resource constraints. To realize truly sustainable development, it is imperative to establish an evaluation system that integrates social, economic, environmental and resource criteria, and optimizes aquaculture systems through a holistic approach. Here, we used analytical hierarchy processes combined with expert judgment and objective data to assess the sustainability of 10 major aquaculture production systems (APSs) in China. Based on the evaluation results, we propose the ecological intensification of aquaculture systems (ELIAS), rationally integrating anthropogenic inputs with aquaculture ecosystem services, to improve the sustainability of APSs. The holistic evaluation system and ELIAS are fundamental and critical for the future development of aquaculture in China and globally.

Cover Image, Volume 14, Issue 3 - Shuang‐lin Dong; Yun‐wei Dong; Ling Cao; Johan Verreth; Yngvar Olsen; Wen‐jing Liu; Qi‐zhi Fang; Yan‐gen Zhou; Li Li; Jing‐yu Li; Yong‐tong Mu; Patrick Sorgeloos (Reviews in Aquaculture, 2022)
The cover image is based on the Review Article Optimization of aquaculture sustainability through ecological intensification in China by Shuang‐lin Dong et al., https://doi.org/10.1111/raq.12648 image

Massive Heat Shock Protein 70 Genes Expansion and Transcriptional Signatures Uncover Hard Clam Adaptations to Heat and Hypoxia - Zhi Hu; Hao Song; Jie Feng; Cong Zhou; Mei-Jie Yang; Pu Shi; Zheng-Lin Yu; Yong-Ren Li; Yong-Jun Guo; Hai-Zhou Li; Tao Zhang (Frontiers in Marine Science, 2022)
Heat shock protein 70 (HSP70) members participate in a wide range of housekeeping and stress-related activities in eukaryotic cells. In marine ecosystems, bivalves encounter abiotic stresses, including high temperatures and low dissolved oxygen. Here, 133 MmHSP70 genes were identified through combined methods including Blastp, HMM and manual filtration, based on the whole Mercenaria mercenaria genome. The MmHSP70 genes were unevenly distributed, and 41 genes (33.08%) were located on Chr 7. Phylogenetic analyses indicated that the MmHSP70 gene family mainly consisted of two clusters and the Hspa12 subfamily underwent lineage-specific expansion. A high-density collinear gene block was observed between M. mercenaria Chr 7 and Cyclina sinensis Chr 14. Tandem duplication MmHSP70 gene pairs experienced different levels of purifying selection, which could be an important source of sequence and functional constraints. MmHSP70 genes showed tissue-specific and stress-specific expression. Most tandem duplication HSP70 gene pairs had high expression under hypoxia stress. HSP70 B2 tandem duplication gene pairs showed significantly increased expression under heat plus severe hypoxia stress. This study provided a comprehensive understanding of the MmHSP70 gene family in the M. mercenaria and laid a significant foundation for further studies on the functional characteristics of MmHSP70 genes during exposure to heat and hypoxia stress.

Secoiridoid glycosides from the fruits of Cornus officinalis - Xin Wang; Xiang-Jian Zhong; Na Zhou; Lin-Lin Ji; Jin-Jie Li; Ning Cai; Qing-Bo Wang; Peng-Cheng Lin; Xiao-Ya Shang (Natural Product Research, 2022)

The genes for sensory perception of sound should be considered in gene diagnosis of congenital sensorineural hearing loss and microtia - Ken Lin; Ding-Yun You; Li-Huan Zhang; Li-Juan Zhou; Jin-Yan Zu; Yang Xiao; Mei-Hua Sun; Dong-Su; Xue Cao; Tie-Song Zhang; Jing Ma (Journal of Applied Genetics, 2022)

Epidemiological characteristics of gonorrhea and its influential meteorological factors: a 14-year retrospective assessment in China - Jin Bu; Liang-Jia Zhou; Xiang Xiao; Qian Yue; Gang Hu; Pei Jiang; Jing Chen; Yu Lin (Environmental Science and Pollution Research, 2022)

Study on water resources carrying capacity in Zhuanglang River Basin - Wen Xu; Chang Zhou; Bingrui Liu; Dongxue Wang; Xingzhu Zhao; Xiaojing Yang; Xiaotao Zhu; Zimu Lin (Environmental Monitoring and Assessment, 2022)
With the rapid development of China’s social economy, the phenomenon of unbalanced regional economic development is increasingly obvious. The shortage of water resources in northwest China is an important constraint to local development. The study on the water resources carrying capacity of the Zhuanglang River Basin plays an important role in the development of local economy; thus, we evaluate the water resources situation of Zhuanglang River Basin by using hydrology-related calculation method, combining with field investigation, visiting relevant departments, and referring to relevant data. Meanwhile, the water resources carrying capacity of 3 counties and 12 townships in the Zhuanglang River Basin in the current year are studied and analyzed based on methods such as fuzzy comprehensive evaluation model and quantitative calculation. Results indicate that the carrying capacity of water resources in Zhuanglang river basin can mostly meet the needs of township, but it is necessary to further optimize the water resources carrying capacity of the Zhuanglang River Basin from the four systems of water resources, society, economy, and ecology in the future. Besides, the results of quantitative calculation show that the maximum economic scale that water resources can withstand in most areas of the Zhuanglang River Basin is the overall well-off level, that is, the per capita domestic water is 80L/(d· person), and the per capita GDP is 10000 yuan/person. But there is still a certain gap to achieve the level, when the people are well-off in an all-round way, the two indexes are correspondently raised to 120L/(d· person), and the per capita GDP is 30,000 yuan/person.

Study on pressure arch effect of xigeda strata tunnel based on experiment and discrete element simulation - Ping Zhou; Yifan Jiang; Feicong Zhou; Jinyi Li; Ming Lin; Jiayong Lin; Zhijie Wang (Bulletin of Engineering Geology and the Environment, 2022)

Shinella oryzae sp. nov., a novel zearalenone-resistant bacterium isolated from rice paddy soil - Ruyu Gao; Juan Zheng; Wei Lu; Xiubin Ke; Ming Chen; Min Lin; Wei Zhang; Zhengfu Zhou (Antonie van Leeuwenhoek, 2022)

Evolutionary and ecological patterns of scatter‐ and larder‐hoarding behaviours in rodents - Yongjun Zhang; Fei Yu; Xianfeng Yi; Weiwei Zhou; Rui Liu; Marcel Holyoak; Lin Cao; Mingming Zhang; Jiani Chen; Zhibin Zhang; Chuan Yan (Ecology Letters, 2022)
Scatter‐ and larder hoarding are the primary strategies of food‐hoarding animals and have important implications for plant‐animal interactions and plant recruitment. However, their origins and influencing factors have not been fully investigated across a wide range of taxa. Our systematic literature search amassed data for 183 seed‐hoarding rodent species worldwide and tested relationships of seed‐hoarding behaviours with phylogenetic signal, functional traits and environmental factors. We found that the evolution of hoarding strategies was not random in phylogeny, and scatter hoarding originated independently multiple times from larder hoarding. Rodents with higher encephalisation quotient (relative brain size), omnivorous diet (related to dependence on seeds) and inhabiting lower latitudes were disproportionately likely to scatter hoard. Despite body mass’s potential relationship with competition through food defence, it was associated with food‐hoarding strategy only in a few families. Our results show the need to study the community and ecological context of food‐hoarding behaviours.

A Comprehensive Correlation Study of Structured Soils in Coastal Area of South China about Structural Characteristics - Chunxiu Lin; Chang Xia; Zhen Liu; Cuiying Zhou (Journal of Marine Science and Engineering, 2022)
Granite residual soil is a common engineering material, and its mechanical properties are of great importance to engineering safety. This kind of soil presents obvious structural characteristics, and many researchers have emphasized the significance of its structural features. According to previous experiments, from a macroscopic perspective, many researchers have investigated the structural relationship between undisturbed and remolded soils, but few studies have considered it in the mesoscopic aspect. Adopting DEM (a mesomechanical simulation method), we can study how the structure affects the mechanical process between undisturbed and remolded soil. Therefore, this paper combines DEM with laboratory tests to study the structural characteristic correlation between undisturbed and remolded soil. The results indicate that a weak cohesion effect exists in undisturbed soil, and the damage of weak cohesion elements accompanies the failure process. Weak cohesion elements in undisturbed soil cause inhomogeneities in deformation, stress state, and damage accumulation, which ultimately causes differences in strength curves. This paper explains the mechanism of the structural effect on mechanical evolution from a mesomechanical perspective. The DEM simulation method proposed in this paper can be applied to structured soils and better guide engineering practice.

Integrated Berth and Crane Scheduling Problem Considering Crane Coverage in Multi-Terminal Tidal Ports under Uncertainty - Meixian Jiang; Jian Zhou; Jiajia Feng; Lin Zhou; Fangzheng Ma; Guanghua Wu (Journal of Marine Science and Engineering, 2022)
In this work, we study the integrated berth and crane scheduling problem in a tidal port with multiple terminals, considering the uncertainties, tides, maximum coverage of cranes and interference between cranes. For coping with the uncertainties, a certain number of randomly generated samples are used to evaluate the solutions, and slack variables are introduced to reduce the impact caused by the variation in vessel arrival and crane operational efficiency. A novel nonlinear mixed integer programming model is first formulated for the problem to minimize the sum of expectation and variance of costs under all samples. An improved adaptive genetic algorithm, combining a simulated annealing mechanism and greedy construction strategy, is developed and implemented by MATLAB. The feasibility and validity of the algorithm and the benefits of multi-terminal collaborative scheduling strategy under uncertainty are evaluated through numerical experiments. The results show that the algorithm can obtain feasible scheduling solutions with higher quality. Compared to the strategy that considers either the uncertainty or the multi-terminal collaborative mechanism, the resulting solution considering both can effectively reduce the cost and improve the competitiveness of the port.

A biosurfactant-producing yeast Rhodotorula sp.CC01 utilizing landfill leachate as nitrogen source and its broad degradation spectra of petroleum hydrocarbons - Xiaoyun Lin; Hanghai Zhou; Feng Zeng; Lijia Jiang; Edidiong Okokon Atakpa; Gen Chen; Chunfang Zhang; Qinglin Xie (World Journal of Microbiology and Biotechnology, 2022)

The Macrophage IL-23/IL-17A Pathway: A New Neuro-Immune Mechanism in Female Mechanical Pain - Zhi Tan; Zhen-Jia Lin; Long-Jun Wu; Li-Jun Zhou (Neuroscience Bulletin, 2022)

TRIP13 knockdown inhibits the proliferation, migration, invasion, and promotes apoptosis by suppressing PI3K/AKT signaling pathway in U2OS cells - De-Chen Yu; Xiang-Yi Chen; Hai-Yu Zhou; De-Quan Yu; Xiao-Lei Yu; Yi-Cun Hu; Rui-Hao Zhang; Xiao-Bo Zhang; Kun Zhang; Mao-Qiang Lin; Xi-Dan Gao; Tao-Wen Guo (Molecular Biology Reports, 2022)

Follicular Fluid-Derived Exosomal MicroRNA-18b-5p Regulates PTEN-Mediated PI3K/Akt/mTOR Signaling Pathway to Inhibit Polycystic Ovary Syndrome Development - Zhi Zhou; Zhihua Tu; Juan Zhang; Can tan; Xiaoyong Shen; Bangbei Wan; Yejuan Li; Anguo Wang; Liqiang Zhao; Jiajia Hu; Ning Ma; Jing Zhou; et al. (Molecular Neurobiology, 2022)

MiR-361-3p alleviates cerebral ischemia–reperfusion injury by targeting NACC1 through the PINK1/Parkin pathway - Xihong Ye; Hua Song; Huimin Hu; Chunli Zhou; Qinyi Chen; Lin Hong; Min Huang; Hongfei Zhu (Journal of Molecular Histology, 2022)

IgE Reactivity of Potential Allergens from the Swimming Crab Portunus trituberculatus and the Research of ELISA Reagent for Detecting Crab Food Anaphylaxis - Xueni Qiu; Qiongyan Zhou; Xiaoxia Zhu; Wei Lin; Changkao Mu; Ronghua Li; Yangfang Ye; Weiwei Song; Ce Shi; Lei Liu; Huan Wang; Chunlin Wang; et al. (Journal of Ocean University of China, 2022)

Sterols and triterpenoids from Ganoderma lucidum and their reversal activities of tumor multidrug resistance - Min Wu; Cui-e Shen; Qiao-fa Lin; Jin-yi Zhong; Yan-fei Zhou; Ben-chen Liu; Jian-hua Xu; Zhi-qiang Zhang; Peng Li (Natural Product Research, 2022)

Extensive sequence divergence between the reference genomes of Taraxacum kok-saghyz and Taraxacum mongolicum - Tao Lin; Xia Xu; Huilong Du; Xiuli Fan; Qingwen Chen; Chunyan Hai; Zijian Zhou; Xiao Su; Liquan Kou; Qiang Gao; Lingwei Deng; Jinsheng Jiang; et al. (Science China Life Sciences, 2022)

Associations of CXCL12 polymorphisms with clinicopathological features in breast cancer: a case-control study - Shuai Lin; Yi Zheng; Meng Wang; Linghui Zhou; Yuyao Zhu; Yujiao Deng; Ying Wu; Dai Zhang; Na Li; Huafeng Kang; Zhijun Dai (Molecular Biology Reports, 2022)
Background Previous studies suggested that CXCL12 was involved in the development, metastasis, and invasion of breast cancer, and genetic variants were associated with the diagnosis and prognosis of patients with breast cancer. The present study was aimed to assess the relationships between CXCL12 polymorphisms (rs1801157, rs2297630, and rs2839693) and susceptibility and clinicopathological features of breast cancer. Methods A case-control study was conducted in 434 breast cancer patients and 450 health controls. Student t -test and chi-square test were used to analyze the differences of age distribution and genotype frequencies between the two groups. Correlations between polymorphisms and clinical parameters were also assessed by chi-square test. The potential effects of the three polymorphisms on CXCL12 were investigated by the public database. Results A statistical association was found between CXCL12 rs1801157 polymorphism and breast cancer risk, possibility of metastasis, and estrogen receptor status. Patients with rs2839693 C/T or C/T-T/T genotypes were more likely to be progesterone receptor-negative. However, no associations of rs2297630 polymorphism with breast cancer risk or any clinicopathological characteristics were observed. In addition, rs2297630 affected the splicing quantitative trait loci of CXCL12 in the subcutaneous fat, rs2839693 polymorphism affected the splicing quantitative trait loci of CXCL12 in the human breast mammary tissues. Conclusions Those results indicated that CXCL12 polymorphisms might be potential diagnostic indicators, and more investigation is needed in the future.

Hippocampal SIRT1-Mediated Synaptic Plasticity and Glutamatergic Neuronal Excitability Are Involved in Prolonged Cognitive Dysfunction of Neonatal Rats Exposed to Propofol - Lin-Hui Ma; Jie Wan; Jing Yan; Ning Wang; Yan-Ping Liu; Hai-Bi Wang; Cheng-Hua Zhou; Yu-Qing Wu (Molecular Neurobiology, 2022)

COX-2/PGE2 Pathway Inhibits the Ferroptosis Induced by Cerebral Ischemia Reperfusion - Yunfei Xu; Ying Liu; Kexin Li; Dun Yuan; Shun Yang; Lin Zhou; Yao Zhao; Shuying Miao; Caihong Lv; Jie Zhao (Molecular Neurobiology, 2022)

Hemorrhage-Induced Sphingosine Kinase 1 Contributes to Ferroptosis-Mediated Secondary Brain Injury in Intracerebral Hemorrhage - Xiaojun Diao; Qi Cui; Ning Tian; Zixian Zhou; Wenjing Xiang; Yanlin Jiang; Jungang Deng; Hongzhan Liao; Xiaohui Lin; Qinghua Li; Rujia Liao (Molecular Neurobiology, 2022)

Establishment of Galectin-3 Time-resolved Fluoroimmunoassay and its Application in Idiopathic Membranous Nephropathy - Xiaomei Yu; Lingli Chen; Bo Lin; Li Zhang; Xue Yang; Xiaobin Liu; Pengguo Xia; Yueming Liu; Shaoxiong Zheng; Xiumei Zhou; Yigang Wang; Yuan Qin; et al. (Journal of Fluorescence, 2022)

Response to Antibiotic exposure and risk of type 2 diabetes mellitus: a systematic review and meta-analysis by Maryam et al. (2021) by J Zhou and K Chen (2021) - Jielin Zhou; Yan Lin; Yong Liu; Keyang Chen (Environmental Science and Pollution Research, 2022)

Exogenous ascorbic acid application alleviates cadmium toxicity in seedlings of two wheat (Triticum aestivum L.) varieties by reducing cadmium uptake and enhancing antioxidative capacity - Zhen Zhou; Chang Wei; Haitao Liu; Qiujuan Jiao; Gezi Li; Jingjing Zhang; Biao Zhang; Weihuan Jin; Di Lin; Guo Chen; Suqin Yang (Environmental Science and Pollution Research, 2022)

Application of Soil and Water Assessment Tool (SWAT) to evaluate the fates of nitrogenous fertilizer in subtropical mountainous watershed tea farms - Guan-Zhou Lin; Shao-Yiu Hsu; Chia-Chun Ho; Chi-Feng Chen; Jr-Chuan Huang; Tsung-Yu Lee (Environmental Monitoring and Assessment, 2022)

Warming effects on grassland productivity depend on plant diversity - Junjiong Shao; Xuhui Zhou; Kees Jan van Groenigen; Guiyao Zhou; Huimin Zhou; Lingyan Zhou; Meng Lu; Jianyang Xia; Lin Jiang; Bruce A. Hungate; Yiqi Luo; Fangliang He; et al. (Global Ecology and Biogeography, 2022)
Aim Climate warming and biodiversity loss both alter plant productivity, yet we lack an understanding of how biodiversity regulates the responses of ecosystems to warming. In this study, we examine how plant diversity regulates the responses of grassland productivity to experimental warming using meta‐analytic techniques. Location Global. Major taxa studied Grassland ecosystems. Methods Our meta‐analysis is based on warming responses of 40 different plant communities obtained from 20 independent studies on grasslands across five continents. Results Our results show that plant diversity and its responses to warming were the most important factors regulating the warming effects on plant productivity, among all the factors considered (plant diversity, climate and experimental settings). Specifically, warming increased plant productivity when plant diversity (indicated by effective number of species) in grasslands was lower than 10, whereas warming decreased plant productivity when plant diversity was greater than 10. Moreover, the structural equation modelling showed that the magnitude of warming enhanced plant productivity by increasing the performance of dominant plant species in grasslands of diversity lower than 10. The negative effects of warming on productivity in grasslands with plant diversity greater than 10 were partly explained by diversity‐induced decline in plant dominance. Main conclusions Our findings suggest that the positive or negative effect of warming on grassland productivity depends on how biodiverse a grassland is. This may mainly be due to differences in how warming may affect plant dominance and subsequent shifts in interspecific interactions in grasslands of different plant diversity levels.

Fine mapping of the tiller inhibition gene TIN4 contributing to ideal plant architecture in common wheat - Zhiqiang Wang; Fangkun Wu; Xudong Chen; Wanlin Zhou; Haoran Shi; Yu Lin; Shuai Hou; Shifan Yu; Hong Zhou; Caixia Li; Yaxi Liu (Theoretical and Applied Genetics, 2022)

The deep blue day is decreasing in China - Su Wang; Gang Huang; Kaiming Hu; Lin Wang; Tie Dai; Chunjiang Zhou (Theoretical and Applied Climatology, 2022)

Interferon-induced transmembrane protein 2 promotes epithelial-mesenchymal transition by activating transforming growth factor-β1/small mother against decapentaplegic 2 signaling in gastric cancer - Yonggang Liu; Minyu Zhou; Jianhua Wu; Zhaowei Wen; Yisheng Fang; Li Lin; Meihua Luo; Li Sun; Wangjun Liao (Molecular Biology Reports, 2022)

piRNAs Interact with Cold-Shock Domain-Containing RNA Binding Proteins and Regulate Neuronal Gene Expression During Differentiation - Charannya Sozheesvari Subhramanyam; Qiong Cao; Cheng Wang; Zealyn Shi-Lin Heng; Zhihong Zhou; Qidong Hu (Molecular Neurobiology, 2022)

Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis - Jie Luo; Zhimin Song; Tao Zhang; Ketan Chu; Jingyi Li; Jianhong Zhou; Jun Lin (Journal of Zhejiang University-SCIENCE B, 2022)

Autophagy plays a double-edged sword role in liver diseases - Jing-chao Zhou; Jing-lin Wang; Hao-zhen Ren; Xiao-lei Shi (Journal of Physiology and Biochemistry, 2022)
As a highly evolutionarily conserved process, autophagy can be found in all types of eukaryotic cells. Such a constitutive process maintains cellular homeostasis in a wide variety of cell types through the encapsulation of damaged proteins or organelles into double-membrane vesicles. Autophagy not only simply eliminates materials but also serves as a dynamic recycling system that produces new building blocks and energy for cellular renovation and homeostasis. Previous studies have primarily recognized the role of autophagy in the degradation of dysfunctional proteins and unwanted organelles. However, there are findings of autophagy in physiological and pathological processes. In hepatocytes, autophagy is not only essential for homeostatic functions but also implicated in some diseases, such as viral hepatitis, alcoholic hepatitis, and hepatic failure. In the present review, we summarized the molecular mechanisms of autophagy and its role in several liver diseases and put forward several new strategies for the treatment of liver disease.

Video target detection of East Asian migratory locust based on the MOG2-YOLOv4 network - Zhao Bai; Zhan Tang; Lei Diao; Shuhan Lu; Xuchao Guo; Han Zhou; Chengqi Liu; Lin li (International Journal of Tropical Insect Science, 2022)

Detection of pulmonary tuberculosis in children using the Xpert MTB/RIF Ultra assay on sputum: a multicenter study - Xiaoshan Peng; Qiong Liao; Min Fang; Yu Zhu; Yan Shi; Shuting Quan; Yacui Wang; Li Duan; Xiaomei Shi; Yang Liu; Manzhi Wang; Qingsong Wei; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2022)

Dissipation and residue of fosthiazate in tomato and cherry tomato and a risk assessment of dietary intake - Sukun Lin; Yi Zhou; Jiyingzi Wu; Zhixiang Zhang; Dongmei Cheng (Environmental Science and Pollution Research, 2022)

Quantitative synthetic MRI reveals grey matter abnormalities in children with drug-naïve attention-deficit/hyperactivity disorder - Shu Su; Yingqian Chen; Yan Dai; Liping Lin; Long Qian; Qin Zhou; Mengsha Zou; Hongyu Zhang; Meina Liu; Xianhong Xiang; Zhiyun Yang (Brain Imaging and Behavior, 2022)

Different effects of the DRD4 genotype on intrinsic brain network connectivity strength in drug-naïve children with ADHD and healthy controls - Shuangli Chen; Andan Qian; Jiejie Tao; Ronghui Zhou; Chuqi Fu; Chuang Yang; Qingxia Lin; JieJie Zhou; Jiance Li; Xiaoqi Huang; Meihao Wang (Brain Imaging and Behavior, 2022)
The dopamine D4 receptor gene (DRD4) has been consistently reported to be associated with attention-deficit/hyperactivity disorder (ADHD). Recent studies have linked DRD4 to functional connectivity among specific brain regions. The current study aimed to compare the effects of the DRD4 genotype on functional integrity in drug-naïve ADHD children and healthy children. Resting-state functional MRI images were acquired from 49 children with ADHD and 37 healthy controls (HCs). We investigated the effects of the 2-repeat allele of DRD4 on brain network connectivity in both groups using a parameter called the degree of centrality (DC), which indexes local functional relationships across the entire brain connectome. A voxel-wise two-way ANCOVA was performed to examine the diagnosis-by-genotype interactions on DC maps. Significant diagnosis-by-genotype interactions with DC were found in the temporal lobe, including the left inferior temporal gyrus (ITG) and bilateral middle temporal gyrus (MTG) (GRF corrected at voxel level p < 0.001 and cluster level p < 0.05, two-tailed). With the further subdivision of the DC network according to anatomical distance, additional brain regions with significant interactions were found in the long-range DC network, including the left superior parietal gyrus (SPG) and right middle frontal gyrus (MFG). The post-hoc pairwise analysis found that altered network centrality related to DRD4 differed according to diagnostic status (p < 0.05). This genetic imaging study suggests that the DRD4 genotype regulates the functional integration of brain networks in children with ADHD and HCs differently. This may have important implications for our understanding of the role of DRD4 in altering functional connectivity in ADHD subjects.

Synthesis of Silver- and Strontium-Substituted Hydroxyapatite with Combined Osteogenic and Antibacterial Activities - Yunfei Li; Wenying Wang; Jing Han; Zirui Li; Qiuxiang Wang; Xue Lin; Kun Ge; Guoqiang Zhou (Biological Trace Element Research, 2022)

Reference Module-Based Analysis of Ovarian Cancer Transcriptome Identifies Important Modules and Potential Drugs - Xuedan Lai; Peihong Lin; Jianwen Ye; Wei Liu; Shiqiang Lin; Zhou Lin (Biochemical Genetics, 2022)

Natural forests promote phosphorus retention in soil - Zhen Yu; Zhou Guoyi; Lei Liu; Stefano Manzoni; Philippe Ciais; Daniel Goll; Josep Peñuelas; Jordi Sardans; Wantong Wang; Jie Zhu; Lin Li; Junhua Yan; et al. (Global Change Biology, 2022)
Soil phosphorus (P) availability often limits plant productivity. Classical theories suggest that total P content declines at the temporal scale of pedogenesis, and ecosystems develop toward the efficient use of scarce P during succession. However, the trajectory of ecosystem P within shorter time scales of succession remains unclear. We analyzed changes to P pools at the early (I), middle (II), and late (III) stages of growth of plantation forests (PFs) and the successional stages of natural forests (NFs) at 1969 sites in China. We found significantly lower P contents at later growth stages compared to earlier ones in the PF ( p p

Two new triterpenoid-chromone hybrids from the rhizomes of Actaea cimicifuga L. (syn. Cimicifuga foetida L.) and their cytotoxic activities - Qiang-Qiang Shi; Ya Gao; Jing Lu; Lin Zhou; Ming-Hua Qiu (Natural Product Research, 2022)

The role of social networks in relocation induced by climate-related hazards: an empirical investigation in China - Jing Tan; Kui Zhou; Li Peng; Lei Lin (Climate and Development, 2022)

Effect of Sodium Salicylate on Calcium Currents and Exocytosis in Cochlear Inner Hair Cells: Implications for Tinnitus Generation - Ting Fan; Meng-Ya Xiang; Ruo-Qiao Zhou; Wen Li; Li-Qin Wang; Peng-Fei Guan; Geng-Lin Li; Yun-Feng Wang; Jian Li (Neuroscience Bulletin, 2022)

New species and new record of Alternaria from onion leaf blight in Myanmar - Aye Aye Htun; Hai Feng Liu; Lin He; Zhen Zhou Xia; Sein Lai Lai Aung; Jian Xin Deng (Mycological Progress, 2022)

The frequency of cannibalism by Spodoptera frugiperda larvae determines their probability of surviving food deprivation - Hualiang He; Ailin Zhou; Li He; Lin Qiu; Wenbing Ding; Youzhi Li (Journal of Pest Science, 2022)

Verification of Real-Time Microbial Monitoring Technology Based on the Principle of Laser-Induced Fluorescence Under USP <1223> Standard and Prospective Application in Our Hospital PIVAS Clean Room - Zhou Geng; Wenbin Yang; Shubo Wei; Lin Wang; Jie Pan (International Journal of Peptide Research and Therapeutics, 2022)

Di(2-ethylhexyl) phthalate (DEHP) and thyroid: biological mechanisms of interference and possible clinical implications - Xueting Zhang; Wen Qi; Qi Xu; Xu Li; Liting Zhou; Lin Ye (Environmental Science and Pollution Research, 2022)

Performance and mechanisms of fly ash for graphene oxide removal from aqueous solution - Ping Jiang; Lin Zhou; Wei Wang; Na Li; Fang Zhang (Environmental Science and Pollution Research, 2022)

Pharmaceuticals in drinking water sources and tap water in a city in the middle reaches of the Yangtze River: occurrence, spatiotemporal distribution, and risk assessment - Peng He; Junmei Wu; Jingqian Peng; Lin Wei; Liping Zhang; Qiaohong Zhou; Zhenbin Wu (Environmental Science and Pollution Research, 2022)

Characteristics of fine particulate matter (PM2.5) at Jinsha Site Museum, Chengdu, China - Jialin Deng; Luman Jiang; Wenwen Miao; Junke Zhang; Guiming Dong; Ke Liu; Juncheng Chen; Tong Peng; Yao Fu; Yunpei Zhou; Xue Huang; Mengqian Hu; et al. (Environmental Science and Pollution Research, 2022)

Molecular Mechanism of Aluminum-Induced Oxidative Damage and Apoptosis in Rat Cardiomyocytes - LiuFang Zhou; Mingjie He; XiaoLan Li; Erbing Lin; YingChuan Wang; Hua Wei; Xi Wei (Biological Trace Element Research, 2022)

Mycorrhizal and rhizobial interactions influence model grassland plant community structure and productivity - Jiqiong Zhou; Gail W. T. Wilson; Adam B. Cobb; Yingjun Zhang; Lin Liu; Xinquan Zhang; Feida Sun (Mycorrhiza, 2022)

Inhibition of FOSL2 aggravates the apoptosis of ovarian cancer cells by promoting the formation of inflammasomes - Jie Li; Li Zhou; Hongye Jiang; Lin Lin; Yinguang Li (Genes & Genomics, 2022)
Background Ovarian cancer is a common gynecological malignancy among female patients and poses a serious threat to women’s health. Although it has been established that Fos-like antigen 2 (FOSL2) is linked to ovarian cancer (OC), its exact role in the development of OC remains unknown. Objective This article aims to investigate the role of FOSL2 in ovarian cancer development. Methods FOSL2 expression in ovarian carcinoma and adjacent tissues was assessed using real-time fluorescent quantitative PCR and western blot. We constructed OE/sh-FOSL2 plasmids and Caspase-1 specific inhibitors (Yvad-CMK) and transfected A 2780 cells with them to identify the relevant cell functions. Furthermore, we used western blot assay to determine the changes in expression of apoptosis-associated speck-like protein containing a CARD (ASC), cysteine aspartate-specific proteasezymogen procaspase 1 (pro-caspase-1), cysteinyl aspartate-specific proteinase-1 (caspase-1), interleukin-1β precursor (pro-IL-1β), interleukin-1β (IL-1β), interleukin-18 precursor (pro-IL-18), and interleukin-18 (IL-18). In addition, we measured the concentration of IL-1β and IL-18 using an enzyme-linked immunosorbent assay (ELISA). Moreover, Tthe level of lactate dehydrogenase (LDH) in the cell supernatant was measured by LDH release assay kit. Results The expression of FOSL2 was significantly higher compared with the surrounding tissues. The proliferation, migration, and invasion of A2780 cells were enhanced after transfection with OE-FOSL2 plasmids; however, the cell apoptosis was significantly decreased. When FOSL2 was overexpressed, the inflammasome-associated proteins such as ASC, caspase-1, IL-1β, and IL-18 were downregulated. Furthermore, FOSL2 induced apoptosis and activated the production of inflammasomes in A2780 cells. Co-therapy with Yvad-CMK and substantially inhibited apoptosis and activation of inflammasomes. Conclusions Inhibition of FOSL2 promotes the apoptosis of OC cells by mediating the formation of an inflammasome.

Molecular epidemiology of type I and II feline coronavirus from cats with suspected feline infectious peritonitis in China between 2019 and 2021 - Lishan Lin; Dawei Yao; Lei Wu; Rubin Fan; Yang Liu; Zhenlei Zhou (Archives of Virology, 2022)

Productivity calculating method in tight gas reservoirs considering the stress sensitivity - Jie He; Xiangdong Guo; Hongjun Cui; Kaiyu Lei; Yanyun Lei; Lin Zhou; Qinghai Liu; Yushuang Zhu; Linyu Liu (Arabian Journal of Geosciences, 2022)

Temporal and spatial distribution characteristics of nutrients in Clarion-Clipperton Fracture Zone in the Pacific in 2017 - Baohong Chen; Kaiwen Zhou; Kang Wang; Jigang Wang; Sumin Wang; Xiuwu Sun; Jinmin Chen; Cai Lin; Hui Lin (Acta Oceanologica Sinica, 2022)

Differential Affinities of a Pocillopora damicornis Galectin to Five Genera of Symbiodiniaceae at Different Temperatures - Xingjuan Wang; Zhongjie Wu; Yibo Wu; Mingxun An; Zhi Zhou; Senjie Lin (Frontiers in Marine Science, 2021)
The symbiosis of coral-Symbiodiniaceae is the quintessential basis of the coral reef ecosystem, and its breakdown results in coral bleaching, one of the most severe ecological catastrophes in the ocean. Critical to the establishment of the symbiosis is the host’s specific recognition of the symbionts through the binding of the coral host’s pattern recognition receptors (PRRs) to the symbiont cell surface’s glycoconjugates. However, the molecular basis for this recognition process is poorly understood. The present study investigated the binding affinities of the coral galectin PdGLT-1 to different symbiodiniacean species under different temperatures. At 25°C, the PdGLT-1 recombinant protein (rPdGLT-1) exhibited different binding affinities to different symbiodiniacean species from five genera, with a significantly higher binding affinity ( p < 0.05) to Fugacium kawagutii (2.6-fold) and Cladocopium goreaui (1.9-fold) than Symbiodinium microadriaticum . The binding topology of rPdGLT-1 differed among the five symbiodiniacean species; for S. microadriaticum , Breviolum minutum , and Durusdinium trenchii , the binding was on some specific sites on the cell surface, whereas for C. goreaui and F. kawagutii , the binding signals were detected over the whole cell surface. Interestingly, PdGLT-1 binding induced agglutination of F. kawagutii cells but not of C. goreaui , explaining why C. goreaui was the most dominant symbiodiniacean symbionts in corals. Moreover, the affinity of rPdGLT-1 to Symbiodiniaceae was affected by temperature, and the highest binding affinities were observed at 30, 20, 30, 35, and 30°C for S. microadriaticum , B. minutum , C. goreaui , D. trenchii , and F. kawagutii , respectively. The optimal binding temperatures were consistent with the current understanding that D. trenchii was the most thermal resistant among these species. These results suggest that the binding affinity of the PRR PdGLT-1 may determine the specificity of host-symbiont pairing and explain why Cladocopium is the dominant symbionts of coral P. damicornis at normal temperature, and corals with Durusdinium symbionts may survive better at high temperature.

An innovative echo detection system with STM32 gated and PMT adjustable gain for airborne LiDAR - Guoqing Zhou; Weihao Li; Xiang Zhou; Yizhi Tan; Gangchao Lin; Xianxing Li; Ronghua Deng (International Journal of Remote Sensing, 2021)

Antioxidant CPA-type indole alkaloids produced from the deep-sea derived fungus Aspergillus sp. SCSIO 41024 - Wei-Hao Chen; Kun-Long Li; Xiu-Ping Lin; Sheng-Rong Liao; Bin Yang; Xue-Feng Zhou; Jun-Jian Wang; Yong-Hong Liu; Jun-Feng Wang (Natural Product Research, 2021)

The Key Regulator of Necroptosis, RIP1 Kinase, Contributes to the Formation of Astrogliosis and Glial Scar in Ischemic Stroke - Yong-Ming Zhu; Liang Lin; Chao Wei; Yi Guo; Yuan Qin; Zhong-Sheng Li; Thomas A. Kent; Claire E. McCoy; Zhan-Xiang Wang; Yong Ni; Xian-Yong Zhou; Hui-Ling Zhang (Translational Stroke Research, 2021)
Necroptosis initiation relies on the receptor-interacting protein 1 kinase (RIP1K). We recently reported that genetic and pharmacological inhibition of RIP1K produces protection against ischemic stroke-induced astrocytic injury. However, the role of RIP1K in ischemic stroke-induced formation of astrogliosis and glial scar remains unknown. Here, in a transient middle cerebral artery occlusion (tMCAO) rat model and an oxygen and glucose deprivation and reoxygenation (OGD/Re)-induced astrocytic injury model, we show that RIP1K was significantly elevated in the reactive astrocytes. Knockdown of RIP1K or delayed administration of RIP1K inhibitor Nec-1 down-regulated the glial scar markers, improved ischemic stroke-induced necrotic morphology and neurologic deficits, and reduced the volume of brain atrophy. Moreover, knockdown of RIP1K attenuated astrocytic cell death and proliferation and promoted neuronal axonal generation in a neuron and astrocyte co-culture system. Both vascular endothelial growth factor D (VEGF-D) and its receptor VEGFR-3 were elevated in the reactive astrocytes; simultaneously, VEGF-D was increased in the medium of astrocytes exposed to OGD/Re. Knockdown of RIP1K down-regulated VEGF-D gene and protein levels in the reactive astrocytes. Treatment with 400 ng/ml recombinant VEGF-D induced the formation of glial scar; conversely, the inhibitor of VEGFR-3 suppressed OGD/Re-induced glial scar formation. RIP3K and MLKL may be involved in glial scar formation. Taken together, these results suggest that RIP1K participates in the formation of astrogliosis and glial scar via impairment of normal astrocyte responses and enhancing the astrocytic VEGF-D/VEGFR-3 signaling pathways. Inhibition of RIP1K promotes the brain functional recovery partially via suppressing the formation of astrogliosis and glial scar. Graphical Abstract

Inhibition of Dectin-1 Ameliorates Neuroinflammation by Regulating Microglia/Macrophage Phenotype After Intracerebral Hemorrhage in Mice - Xiongjie Fu; Hanhai Zeng; Jikuang Zhao; Guoyang Zhou; Hang Zhou; Jianfeng Zhuang; Chaoran Xu; Jianru Li; Yucong Peng; Yang Cao; Yin Li; Huaijun Chen; et al. (Translational Stroke Research, 2021)

Evolutionary characteristics and phylogeny of cotton chloroplast tRNAs - Ning Wang; Wan-Lin Dong; Xiao-Jing Zhang; Tong Zhou; Xiao-Juan Huang; Bao-Guo Li; Jian-Ni Liu; Xiong-Feng Ma; Zhong-Hu Li (Planta, 2021)

Hotter and drier climate made the Mediterranean Europe and Northern Africa region a shrubbier landscape - Wei Fang; Chuixiang Yi; Deliang Chen; Peipei Xu; George Hendrey; Nir Krakauer; Katherine Jensen; Shan Gao; Zihan Lin; Gabriella Lam; Qin Zhang; Tao Zhou (Oecologia, 2021)

Saikosaponin-d alleviates hepatic fibrosis through regulating GPER1/autophagy signaling - Yirong Chen; Renye Que; Na Zhang; Liubing Lin; Mengen Zhou; Yong Li (Molecular Biology Reports, 2021)
Background Hepatic fibrosis is the final pathway of chronic liver disease characterized by excessive accumulation of extracellular matrix (ECM), which eventually develop into cirrhosis and liver cancer. Emerging studies demonstrated that Saikosaponin-d (SSd) exhibits a protective role in liver fibrosis. However, the mechanism underlying anti-liver fibrosis of SSd in vivo and in vitro remains unclear. Methods and results Transforming growth factor (TGF)-β and carbon tetrachloride (CCl 4 ) were used for creating liver fibrosis model in vitro and in vivo, respectively. The role of SSd in regulating liver fibrosis was assessed through Sirius red and Masson staining, and IHC assay. We found that SSd attenuated remarkably CCl 4 -induced liver fibrosis as evidenced by decreased collagen level, and decreased expression of fibrotic markers Col 1 and α-SMA. Meanwhile, SSd repressed autophagy activation as suggested by decreased BECN1 expression and increased p62 expression. Compared with HSCs from CCl 4 -treated group, the primary HSCs from SSd-treated mice exhibited a marked inactivation of autophagy. Mechanistically, SSd treatment enhanced the expression of GPER1 in primary HSCs and in TGF-β-treated LX-2 cells. GPER1 agonist G1 repressed autophagy activation, whereas GPER1 antagonist G15 activated autophagy and G15 also damaged the function of SSd on suppressing autophagy, leading to subsequent increased levels of fibrotic marker level in LX-2 cells. Conclusions Our findings highlight that SSd alleviates hepatic fibrosis by regulating GPER1/autophagy pathway.

Melatonin Reduces Neuroinflammation and Improves Axonal Hypomyelination by Modulating M1/M2 Microglia Polarization via JAK2-STAT3-Telomerase Pathway in Postnatal Rats Exposed to Lipopolysaccharide - Qiuping Zhou; Lanfen Lin; Haiyan Li; Huifang Wang; Shuqi Jiang; Peixian Huang; Qiongyu Lin; Xuan Chen; Yiyu Deng (Molecular Neurobiology, 2021)
Microglia activation and associated inflammation are implicated in the periventricular white matter damage (PWMD) in septic postnatal rats. This study investigated whether melatonin would mitigate inflammation and alleviate the axonal hypomyelination in the corpus callosum in septic postnatal rats. We further explored if this might be related to the modulation of microglial polarization from M1 phenotype to M2 through the JAK2/STAT3/telomerase pathway. We reported here that indeed melatonin not only can it reduce the neurobehavioral disturbances in LPS-injected rats, but it can also dampen microglia-mediated inflammation. Thus, in LPS + melatonin group, the expression of proinflammatory mediators in M1 phenotype microglia was downregulated. As opposed to this, M2 microglia were increased which was accompanied by upregulated expression of anti-inflammatory mediators along with telomerase reverse transcriptase or melatonin receptor 1(MT1). In parallel to this was decreased NG2 expression but increased expression of myelin and neurofilament proteins. Melatonin can improve hypomyelination which was confirmed by electron microscopy. In vitro in primary microglia stimulated by LPS, melatonin decreased the expression of proinflammatory mediators significantly; but it increased the expression of anti-inflammatory mediators. Additionally, the expression levels of p-JAK2 and p-STAT3 were significantly elevated in microglia after melatonin treatment. Remarkably, the effect of melatonin on LPS-treated microglia was blocked by melatonin receptor, JAK2, STAT3 and telomerase reverse transcriptase inhibitors, respectively. Taken together, it is concluded that melatonin can attenuate PWMD through shifting M1 microglia towards M2 via MT1/JAK2/STAT3/telomerase pathway. The results suggest a new therapeutic strategy whereby melatonin may be adopted to convert microglial polarization from M1 to M2 phenotype that would ultimately contribute to the attenuation of PWMD.

Histological alterations, oxidative stress, and inflammatory response in the liver of swamp eel (Monopterus albus) acutely exposed to copper - Lin Liu; Qiubai Zhou; Changgao Lin; Li He; Lili Wei (Fish Physiology and Biochemistry, 2021)

Antibiotic exposure and risk of type 2 diabetes mellitus: a systematic review and meta-analysis - Jielin Zhou; Yan Lin; Yong Liu; Keyang Chen (Environmental Science and Pollution Research, 2021)

Mechanisms of cardiovascular toxicity induced by PM2.5: a review - Tianyang Zhao; Wen Qi; Pan Yang; Liwei Yang; Yanbin Shi; Liting Zhou; Lin Ye (Environmental Science and Pollution Research, 2021)

Occurrence, source apportionment, and carcinogenic risk assessment of polycyclic aromatic hydrocarbons in urban road dusts in Shanghai - Xue-Tong Wang; Rui Fu; Ying Zhou; Cheng-Lin Wang; Guo-Fa Ren; Xiao-Li Wang; Hui Li (Environmental Science and Pollution Research, 2021)

Synthesis and characterization of CuxO/Bi2O3 oxides for removal of HCHO under visible light irradiation - Zhihao Lin; Mianwu Meng; Hua Ding; Qi Zhang; Chaomin Duan; Chaoshu Chen; Siyu Huang; Zhenming Zhou (Environmental Science and Pollution Research, 2021)

Prevalence and Implications of Per- and Polyfluoroalkyl Substances (PFAS) in Settled Dust - Tina Savvaides; Jeremy P. Koelmel; Yakun Zhou; Elizabeth Z. Lin; Paul Stelben; Juan J. Aristizabal-Henao; John A. Bowden; Krystal J. Godri Pollitt (Current Environmental Health Reports, 2021)

Adsorption Performance and Mechanism of Synthetic Schwertmannite to Remove Low-Concentration Fluorine in Water - Zehong Zhang; Le Wang; Bo Zhou; Sichang Wang; Lin Fan; Sihai Hu; Yaoguo Wu (Bulletin of Environmental Contamination and Toxicology, 2021)

Long-term changes of water acidity in an intact forested watershed in south China - Xiao-dong Liu; Ying-jie Feng; Qi-feng Mo; Guo-wei Chu; Yue-lin Li; Qian-mei Zhang; Wei-qiang Zhang; Xian-hua Gan; Qing Zhou (Journal of Mountain Science, 2021)

Nitrogen absorption by alpine forage species based on 15N tracer technique in a hydroponic culture - Yan-fang Liu; Wen-ying Wang; Xiao-lin Ma; Pan Liu; Hua-kun Zhou; Zhe Chen; Chong Yang; Jin-hong Guan (Journal of Mountain Science, 2021)

Correction to: 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Bernard R. Agwanda; Rim Al Kubrusli; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Christopher F. Basler; et al. (Archives of Virology, 2021)

2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Bernard R. Agwanda; Rim Al Kubrusli; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Christopher F. Basler; et al. (Archives of Virology, 2021)

Characterization and identification of SFDC ‐1, a novel AmpC ‐type β‐lactamase in Serratia fonticola - Xu Dong; Peiyao Zhang; Kexin Zhou; Jialei Liang; Qiaoling Li; Xueya Zhang; Danying Zhou; Wei Lu; Zhewei Sun; Hongmao Liu; Junwan Lu; Xi Lin; et al. (Environmental Microbiology, 2021)
Summary The clinical and environmental infections caused by AmpC β‐lactamases have been increasingly reported recently. In this study, we characterize the novel chromosome‐encoded AmpC β‐lactamase SFDC‐1 identified in Serratia fonticola strain R28, which was isolated from a rabbit raised on a farm in southern China. SFDC‐1 shared the highest amino acid identity of 79.6% with the functionally characterized AmpC β‐lactamase gene bla YRC‐1 , although it had highly homologous functionally uncharacterized relatives in the same species from different sources, including some of the clinical significance. The cloned bla SFDC‐1 exhibited resistance to a broad spectrum of β‐lactam antibiotics, including most cephalosporins with the highest resistance to ampicillin, cefazolin and ceftazidime, with increased MIC levels ≥128‐fold compared with the control strains. The purified SFDC‐1 showed catalytic activities against β‐lactams with the highest catalytic activity to cefazolin. The genetic context of bla SFDC‐1 and its relatives was conserved in the chromosome, and no mobile genetic elements were found surrounding them.

A New Instrumental Array in Sichuan, China, to Monitor Vibrations and Perturbations of the Lithosphere, Atmosphere, and Ionosphere - Chieh-Hung Chen; Yang-Yi Sun; Kai Lin; Chen Zhou; Rui Xu; Haiyin Qing; Yongxin Gao; Tao Chen; Fei Wang; Huaizhong Yu; Peng Han; Chi-Chia Tang; et al. (Surveys in Geophysics, 2021)

Rapid visual genotyping method for germline mutants with small genomic fragment deletion by allele-specific PCR and lateral flow nucleic acid biosensor - Qiuju Su; Xiang Zhou; Tianwen Wu; Kui Li; Wentao Xu; Zhenyu Lin; Ping Shen; Bang Liu (Molecular Biology Reports, 2021)

The diversity of alkane-degrading bacterial communities in seagrass ecosystem of the South China Sea - Ying Zhang; Qingsong Yang; Juan Ling; Yanying Zhang; Weiguo Zhou; Manzoor Ahmad; Xiangcheng Lin; Liyun Lin; Qiuying Peng; Junde Dong (Ecotoxicology, 2021)

The distribution characteristics of β-propeller phytase genes in rhizosphere sediment provide insight into species specialty from phytic mineralization in subtropical and tropical seagrass ecosystems - Liyun Lin; Juan Ling; Qiuying Peng; Xiancheng Lin; Weiguo Zhou; Yanying Zhang; Qingsong Yang; Manzoor Ahamad; Ying Zhang; Cong Wang; Youshao Wang; Junde Dong (Ecotoxicology, 2021)

Spatiotemporal change of vegetation coverage recovery and its driving factors in the Wenchuan earthquake-hit areas - Xiao-fei Sun; Lin-guo Yuan; Ying-zhi Zhou; Huai-yong Shao; Xian-feng Li; Ping Zhong (Journal of Mountain Science, 2021)

Diversity and abundance of diazotrophic communities of seagrass Halophila ovalis based on genomic and transcript level in Daya Bay, South China Sea - Weiguo Zhou; Dewen Ding; Qingsong Yang; Juan Ling; Manzoor Ahmad; Xiancheng Lin; Liyun Lin; Ying Zhang; Junde Dong (Archives of Microbiology, 2021)

Pseudomonas nanhaiensis sp. nov., a lipase-producing bacterium isolated from deep-sea sediment of the South China Sea - Yu Pang; Yage Zhang; Mengru Chen; Wei Lu; Ming Chen; Yongliang Yan; Min Lin; Wei Zhang; Zhengfu Zhou (Antonie van Leeuwenhoek, 2021)

Local community assembly processes shape β‐diversity of soil phoD ‐harbouring communities in the Northern Hemisphere steppes - Lin Xu; Nianpeng He; Xiangzhen Li; Huili Cao; Chaonan Li; Ruili Wang; Changhui Wang; Minjie Yao; Shungui Zhou; Junming Wang (Global Ecology and Biogeography, 2021)
Aim The contemporary coexistence theory suggests that species pool, environmental filtering, dispersal assembly processes, ecological drift and biotic interactions collectively determine the β‐diversity of communities. However, we know little about the biogeographical patterns of the β‐diversity of microbial communities harbouring the alkaline phosphatase phoD gene ( phoD communities, hereafter) and whether these mechanisms are all‐important in shaping phoD communities’ β‐diversity in natural steppe ecosystems. Location Northern Hemisphere steppes. Time period July to August 2018. Major taxa studied Alkaline phosphatase ( phoD gene) encoding community. Methods Using the high throughput amplicon sequencing method, soil phoD communities were comparatively studied along three representative regions of the Northern Hemisphere steppes, namely the Qinghai‐Tibetan Plateau, Inner Mongolian Plateau and the Loess Plateau. Each region harbours three types of steppes (habitats): meadow, typical and desert steppes. Results We observed significantly higher phoD β‐diversity in the Qinghai‐Tibetan than in the Loess and Inner Mongolian Plateaus and significantly lower β‐diversity in the typical steppes than in other steppe types. The decay rates of phoD β‐diversity with geographical distance varied in different steppe regions and types. The phoD β‐diversity was not significantly influenced by species pool; instead, environmental filtering, dispersal assembly processes, ecological drift and biotic interactions jointly shaped the β‐diversity patterns. The β‐deviation variations (β‐diversity excluding the effects of species pool) were influenced by spatial and environmental factors and biotic interactions, among which soil pH was the key environmental determinant. The soil pH driving β‐diversity mechanism was steppe region and habitat specific. Main conclusions The biogeographical patterns of phoD β‐diversity were mainly driven by local community assembly processes in the Northern Hemisphere steppes.

Two new cephalochromin derivative from the Alternaria sp. ZG22 - Xin-Ming Song; Xue-Ming Zhou; Ya-Ling Li; Li-Bing Huang; Cai-Cui Chen; Yan Gao; Lin He; Xiao-qun Mao; Bing Chen; Jing-Wen Liu; Hui-Jie Liu; Xiao-Ping Song; et al. (Natural Product Research, 2021)

Mapping coastal wetlands in the Yellow River Delta, China during 2008–2019: impacts of valid observations, harmonic regression, and critical months - Zhanpeng Wang; Yinghai Ke; Mengmeng Chen; Demin Zhou; Lin Zhu; Junhong Bai (International Journal of Remote Sensing, 2021)

The Discovery of Circadian Rhythm of Feeding Time on Digestive Enzymes Activity and Their Gene Expression in Sinonovacula constricta Within a Light/Dark Cycle - Yanzi Liu; Hanhan Yao; Tingting Zhou; Zhihua Lin; Yinghui Dong (Frontiers in Marine Science, 2021)
The circadian rhythm has a great impact on the growth, metabolism and development of animals, but little is known about the circadian rhythm of marine bivalves. Understanding of the feeding rhythm is of great significance to increase the yield of razor clam Sinonovacula constricta , an economically important bivalve mollusk. The aim of this experiment was to study the effects of circadian rhythm of feeding time on digestive enzymes activities and their gene expression in S. constricta within a light (ZT8-ZT20)/dark (ZT20-ZT8) cycle. The present results showed that circadian rhythm of feeding rate (FR) was highly associated with digestive enzyme activities and relative expression of their genes. The highest values of FR were basically observed in the night from ZT0-ZT2 and ZT6-ZT8, which were significantly higher than those values in the daytime from ZT12-ZT14 and ZT18-ZT20 ( P < 0.05). The digestive enzymes activities displayed the highest values at ZT2 and ZT8, and the lowest at ZT14 and ZT20. Among them, cellulase and pepsin were found to have significantly different activities ( P < 0.05), rather than amylase and lipase. Notably, the relative expression of digestive enzyme genes shared the similar pattern with the activities of digestive enzymes. The highest values of relative gene expression of amylase ( AMY ), lipase ( LIP ), cellulase ( CEL ), and pepsin ( PEP ) were found at ZT2 and ZT8 in the night, while the lowest values were found at ZT14 during the day. It is therefore suggested that the biological clock may regulate the process from feeding to digestion. Furthermore, it might be better to feed at night to reduce cultivating cost and increase economic benefits in the farming industry of S. constricta .

Phylogenetic analysis of Engleromyces sinensis and identification of cytochalasin D from culture - Hao Zhou; Qiu-Tong Wang; Xin Tong; Cheng-Lin Hou (Mycological Progress, 2021)

Meta-analyses of maternal exposure to atmospheric particulate matter and risk of congenital anomalies in offspring - Guangxia Yu; Yao Chen; Jianping Tang; Zhifeng Lin; Fuli Zheng; Chunyan Zheng; Jinfu Zhou; Qianqian Su; Siying Wu; Huangyuan Li (Environmental Science and Pollution Research, 2021)

Dynamics of antibiotic resistance and its association with bacterial community in a drinking water treatment plant and the residential area - Fu-Yi Huang; Qing-Lin Chen; Xian Zhang; Roy Neilson; Jian-Qiang Su; Shu-Yi-Dan Zhou (Environmental Science and Pollution Research, 2021)

Added value of kilometer-scale modeling over the third pole region: a CORDEX-CPTP pilot study - Xu Zhou; Kun Yang; Lin Ouyang; Yan Wang; Yaozhi Jiang; Xin Li; Deliang Chen; Andreas Prein (Climate Dynamics, 2021)

Damage mechanism of tunnels in the high-content salt rock stratum - Ping Zhou; Jinyi Li; Yifan Jiang; Feicong Zhou; Ming Lin; Jiayong Lin; Zhijie Wang (Bulletin of Engineering Geology and the Environment, 2021)

Degraded polysaccharides from Porphyra haitanensis: purification, physico-chemical properties, antioxidant and immunomodulatory activities - Yun-Feng Huo; Yin-Ting Li; Wei Xia; Chong Wang; Yuan-Yuan Xie; Yan-Bo Wang; Tao Zhou; Ling-Lin Fu (Glycoconjugate Journal, 2021)

Shaking table tests on calcareous sand retaining walls reinforced by concrete canvas geocell - Jie Tan; Lin Zhou; Guangya Ding (Arabian Journal of Geosciences, 2021)

Ambient climate determines the directional trend of community stability under warming and grazing - Peipei Liu; Wangwang Lv; Jianping Sun; Caiyun Luo; Zhenhua Zhang; Xiaoxue Zhu; Xingwu Lin; Jichuang Duan; Guangping Xu; Xiaofeng Chang; Yigang Hu; Qiaoyan Lin; et al. (Global Change Biology, 2021)
Changes in ecological processes over time in ambient treatments are often larger than the responses to manipulative treatments in climate change experiments. However, the impacts of human‐driven environmental changes on the stability of natural grasslands have been typically assessed by comparing differences between manipulative plots and reference plots. Little is known about whether or how ambient climate regulates the effects of manipulative treatments and their underlying mechanisms. We collected two datasets, one a 36‐year long‐term observational dataset from 1983 to 2018, and the other a 10‐year manipulative asymmetric warming and grazing experiment using infrared heaters with moderate grazing from 2006 to 2015 in an alpine meadow on the Tibetan Plateau. The 36‐year observational dataset shows that there was a nonlinear response of community stability to ambient temperature with a positive relationship between them due to an increase in ambient temperature in the first 25 years and then a decrease in ambient temperature thereafter. Warming and grazing decreased community stability with experiment duration through an increase in legume cover and a decrease in species asynchrony, which was due to the decreasing background temperature through time during the 10‐year experiment period. Moreover, the temperature sensitivity of community stability was higher under the ambient treatment than under the manipulative treatments. Therefore, our results suggested that ambient climate may control the directional trend of community stability while manipulative treatments may determine the temperature sensitivity of the response of community stability to climate relative to the ambient treatment. Our study emphasizes the importance of the context dependency of the response of community stability to human‐driven environmental changes.

Image Segmentation in 3D Brachytherapy Using Convolutional LSTM - Jui-Hung Chang; Kai-Hsiang Lin; Ti-Hao Wang; Yu-Kai Zhou; Pau-Choo Chung (Journal of Medical and Biological Engineering, 2021)

A new monoterpene-lactone with neuroprotective activity from corn silk - Wei-Yu Zhou; Tian-Ming Lv; Zi-Lin Hou; Ming Bai; Bin Lin; Xiao-Xiao Huang; Shao-Jiang Song (Natural Product Research, 2021)

Identifying rainfall threshold of flash flood using entropy decision approach and hydrological model method - Kairong Lin; Jiaqi Zhou; Ruhao Liang; Xiaozhang Hu; Tian Lan; Meixian Liu; Xin Gao; Denghua Yan (Natural Hazards, 2021)

Non-coding RNA: insights into the mechanism of methamphetamine neurotoxicity - Ying-Jian Gu; Lei Chen; Lin Cheng; Ming-Yuan Zhou; Yun Wang (Molecular and Cellular Biochemistry, 2021)

High-throughput sequencing clarifies the spatial structures of microbial communities in cadmium-polluted rice soils - Li Song; Zhenzhi Pan; Yi Dai; Lin Chen; Li Zhang; Qilin Liao; Xiezhi Yu; Hongyan Guo; Guisheng Zhou (Environmental Science and Pollution Research, 2021)

Future variation in mountainous discharge in arid northwestern China: A basin case study - Lei Wu; Chang-bin Li; Xu-hong Xie; Jia-nan Lv; Jian-mei Wei; Xuan Zhou; Lin-shan Yang (Journal of Mountain Science, 2021)

3D Step-by-step inversion strategy for audio magnetotellurics data based on unstructured mesh - San Cheng; Zhi-Yong Zhang; Feng Zhou; Man Li; Hui Chen; Fu-Sheng Shi; Lin-Pin Huang; Yong Li (Applied Geophysics, 2021)

Wogonin Accelerates Hematoma Clearance and Improves Neurological Outcome via the PPAR-γ Pathway After Intracerebral Hemorrhage - Jianfeng Zhuang; Yucong Peng; Chi Gu; Huihui Chen; Zheng Lin; Hang Zhou; Xiao Wu; Jianru Li; Xiaobo Yu; Yang Cao; Hanhai Zeng; Xiongjie Fu; et al. (Translational Stroke Research, 2021)

Experimental and Numerical Investigations on the Macro-Meso Shear Mechanical Behaviors of Artificial Rock Discontinuities with Multiscale Asperities - Xinrong Liu; Bin Xu; Guangyi Lin; Junhui Huang; Xiaohan Zhou; Yingkun Xie; Jiwen Wang; Fei Xiong (Rock Mechanics and Rock Engineering, 2021)

Geographic modeling and simulation systems for geographic research in the new era: Some thoughts on their development and construction - Min Chen; Guonian Lv; Chenghu Zhou; Hui Lin; Zaiyang Ma; Songshan Yue; Yongning Wen; Fengyuan Zhang; Jin Wang; Zhiyi Zhu; Kai Xu; Yuanqing He (Science China Earth Sciences, 2021)
Regionality, comprehensiveness, and complexity are regarded as the basic characteristics of geography. The exploration of their core connotations is an essential way to achieve breakthroughs in geography in the new era. This paper focuses on the important method in geographic research: Geographic modeling and simulation. First, we clarify the research requirements of the said three characteristics of geography and its potential to address geo-problems in the new era. Then, the supporting capabilities of the existing geographic modeling and simulation systems for geographic research are summarized from three perspectives: Model resources, modeling processes, and operational architecture. Finally, we discern avenues for future research of geographic modeling and simulation systems for the study of regional, comprehensive and complex characteristics of geography. Based on these analyses, we propose implementation architecture of geographic modeling and simulation systems and discuss the module composition and functional realization, which could provide theoretical and technical support for geographic modeling and simulation systems to better serve the development of geography in the new era.

Role of nucleus accumbens microRNA-181a and MeCP2 in incubation of heroin craving in male rats - Wenjin Xu; Qingxiao Hong; Zi Lin; Hong Ma; Weisheng Chen; Dingding Zhuang; Huaqiang Zhu; Miaojun Lai; Dan Fu; Wenhua Zhou; Huifen Liu (Psychopharmacology, 2021)

A New Approach to Model Sporadic Alzheimer’s Disease by Intracerebroventricular Streptozotocin Injection in APP/PS1 Mice - Sally Kelliny; Liying Lin; Isaac Deng; Jing Xiong; Fiona Zhou; Mohammed Al-Hawwas; Larisa Bobrovskaya; Xin-Fu Zhou (Molecular Neurobiology, 2021)

Characteristics of bacterial community and ARGs profile in engineered goldfish tanks with stresses of sulfanilamide and copper - Benjamin Makimilua Tiimub; Zhen-chao Zhou; Lin Zhu; Yang Liu; Xin-Yi Shuai; Lan Xu; Christophe’ Niyungeko; Ling-Xuan Meng; Yu-Jie Sun; Hong Chen (Environmental Science and Pollution Research, 2021)

Whole brain volume and cortical thickness abnormalities in Wilson’s disease: a clinical correlation study - Yukun Song; Lin Zou; Jing Zhao; Xiangxue Zhou; Yingqian Huang; Haishan Qiu; Haiwei Han; Zhiyun Yang; Xunhua Li; Xiaoying Tang; Jianping Chu (Brain Imaging and Behavior, 2021)

Three-Dimensional Mantle Flow and Temperature Structure Beneath the Shatsky Rise Ridge-Ridge-Ridge Triple Junction - Jinchang Zhang; Zhiyuan Zhou; Min Ding; Jian Lin (Journal of Ocean University of China, 2021)

Effect of PAHs on nitrogen-fixing and sulfate-reducing microbial communities in seagrass Enhalus acoroides sediment - Juan Ling; Weiguo Zhou; Qingsong Yang; Xiancheng Lin; Ying Zhang; Manzoor Ahmad; Qinying Peng; Junde Dong (Archives of Microbiology, 2021)

Effects of diethyl aminoethyl hexanoate on the physiology and selenium absorption of grape seedlings - Lei Liu; Jiaxi Han; Lili Deng; Huixuan Zhou; Yuhui Bie; Qianhe Jing; Lijin Lin; Jin Wang; Ming’an Liao (Acta Physiologiae Plantarum, 2021)

Long‐term nitrogen input alters plant and soil bacterial, but not fungal beta diversity in a semiarid grassland - Weixing Liu; Lingli Liu; Xian Yang; Meifeng Deng; Zhou Wang; Pandeng Wang; Sen Yang; Ping Li; Ziyang Peng; Lu Yang; Lin Jiang (Global Change Biology, 2021)
Anthropogenic nitrogen (N) input is known to alter plant and microbial α‐diversity, but how N enrichment influences β‐diversity of plant and microbial communities remains poorly understood. Using a long‐term multilevel N addition experiment in a temperate steppe, we show that plant, soil bacterial and fungal communities exhibited different responses in their β‐diversity to N input. Plant β‐diversity decreased linearly as N addition increased, as a result of increased directional environmental filtering, where soil environmental properties largely explained variation in plant β‐diversity. Soil bacterial β‐diversity first increased then decreased with increasing N input, which was best explained by corresponding changes in soil environmental heterogeneity. Soil fungal β‐diversity, however, remained largely unchanged across the N gradient, with plant β‐diversity, soil environmental properties, and heterogeneity together explaining an insignificant fraction of variation in fungal β‐diversity, reflecting the importance of stochastic community assembly. Our study demonstrates the divergent effect of N enrichment on the assembly of plant, soil bacterial and fungal communities, emphasizing the need to examine closely associated fundamental components (i.e., plants and microorganisms) of ecosystems to gain a more complete understanding of ecological consequences of anthropogenic N enrichment.

Numerical Investigation to the Effect of Suction-Induced Seepage on the Settlement in the Underwater Vacuum Preloading with Prefabricated Vertical Drains - Shu Lin; Dengfeng Fu; Zefeng Zhou; Yue Yan; Shuwang Yan (Journal of Marine Science and Engineering, 2021)
Vacuum preloading combined with prefabricated vertical drains (PVDs) has the potential to improve the soft sediments under water, however, its development is partly limited by the unclear understanding of the mechanism. This paper aims to extend the comprehension of the influential mechanism of overlapping water in the scenario of underwater vacuum preloading with PVDs. The systematic investigations were conducted by small strain finite element drained analyses, with the separated analysis schemes considering suction-induced consolidation, seepage and their combination. The development of settlement in the improved soil region and the evolution of seepage flow from the overlapping water through the non-improved soil region into improved zone are examined in terms of the build-up of excess pore pressure. Based on the results of numerical analyses, a theoretical approach was set out. It was capable to estimate the time-dependent non-uniform settlement along the improved soil surface in response to the combined effects of suction-induced consolidation and seepage. The difference of underwater and onshore vacuum preloading with PVDs is discussed with some practical implication and suggestion provided.

The Characteristic of Critical Genes in Neuroendocrine System and Their Regulation on Food Habit Transition and Metamorphosis of Veined Rapa Whelk Rapana venosa (Valenciennes, 1846) - Mei-Jie Yang; Jie Feng; Hao Song; Zheng-Lin Yu; Pu Shi; Jian Liang; Zhi Hu; Cong Zhou; Xiao-Lin Wang; Tao Zhang (Frontiers in Marine Science, 2021)
Metamorphosis is a critical developmental event in mollusks, and neuroendocrine system plays an essential role in this process. Rapana venosa is an economically important shellfish in China, but the artificial technology of R. venosa aquaculture is limited by metamorphosis. As a carnivorous gastropod, food habit transition makes the mechanism of R. venosa metamorphosis more complex. To investigate the changes in the neuroendocrine system and to reveal its role in regulating the food habit transition and metamorphosis of R. venosa , we cloned the cDNA sequences encoding 5-hydroxytryptamine receptor ( Rv-5HTR ), nitric oxide synthetase ( Rv-NOS ) and cholecystokinin receptor ( Rv-CCKR ), and investigated their expression by quantitative real-time PCR analysis, and explore the spatio-temporal changes of 5-HT protein expression using Immunohistochemical (IHC) analysis. The expression of the three geens was significantly increased in the early intramembrane veliger stage, which indicates that the three genes are related to the development of digestive system. Additionally, expression of the three genes was decreased after metamorphosis, while Rv-NOS and Rv-CCKR were increasingly expressed in competent larvae, which may help the larvae find suitable environments and promote digestive system development for metamorphosis, and the result of 5-HT IHC analysis also reflects the development of neuroendocrine system. Furthermore, results show that CCK can effect the expression of digestive enzyme, NOS and 5-HT receptor. Finally, based on the present results, we hypothesized that CCK and CCK receptor may be critical regulatory factors of food habit transition and metamorphosis. These results might provide information on the development of neuroendocrine system of R. venosa , and new insight into the regulation of the food habit transition and metamorphosis of gastropods.

Failure mechanism of a slow-moving landslide on September 27, 2020, in Chang Nong Village, Guangxi, China - Jiaming Zhang; Zhi Zhou; Feng Lin; Qinggang Yang; Yi Luo (Landslides, 2021)

Identification of potential sex-related genes in Siniperca chuatsi - Qiaoying Zhu; Chong Han; Cheng Peng; Xingni Zhou; Chongwei Wang; Linqiang Han; Shuisheng Li; Guifeng Li; Haoran Lin; Yong Zhang (Journal of Oceanology and Limnology, 2021)

Characteristics of dissolved organic matter in lakes with different eutrophic levels in southeastern Hubei Province, China - Weixiang Ren; Xiaodong Wu; Xuguang Ge; Guiying Lin; Mengdie Zhou; Zijie Long; Xinhui Yu; Wei Tian (Journal of Oceanology and Limnology, 2021)

Binding of gephyrin to microtubules is regulated by its phosphorylation at Ser270 - Lin Zhou; Eva Kiss; Rebecca Demmig; Joachim Kirsch; Ralph Alexander Nawrotzki; Jochen Kuhse (Histochemistry and Cell Biology, 2021)
Gephyrin is a multifunctional scaffolding protein anchoring glycine- and subtypes of GABA type A- receptors at inhibitory postsynaptic membrane specializations by binding to the microtubule (MT) and/or the actin cytoskeleton. However, the conditions under which gephyrin can bind to MTs and its regulation are currently unknown. Here, we demonstrate that during the purification of MTs from rat brain by sedimentation of polymerized tubulin using high-speed centrifugation a fraction of gephyrin was bound to MTs, whereas gephyrin phosphorylated at the CDK5-dependent site Ser270 was detached from MTs and remained in the soluble protein fraction. Moreover, after collybistin fostered phosphorylation at Ser270 the binding of a recombinant gephyrin to MTs was strongly reduced in co-sedimentation assays. Correspondingly, upon substitution of wild-type gephyrin with recombinant gephyrin carrying alanine mutations at putative CDK5 phosphorylation sites the binding of gephyrin to MTs was increased. Furthermore, the analysis of cultured HEK293T and U2OS cells by immunofluorescence-microscopy disclosed a dispersed and punctuated endogenous gephyrin immunoreactivity co-localizing with MTs which was evidently not phosphorylated at Ser270. Thus, our study provides additional evidence for the binding of gephyrin to MTs in brain tissue and in in vitro cell systems. More importantly, our findings indicate that gephyrin-MT binding is restricted to a specific gephyrin fraction and depicts phosphorylation of gephyrin as a regulatory mechanism of this process by showing that soluble gephyrin detached from MTs can be detected specifically with the mAb7a antibody, which recognizes the Ser270 phosphorylated- version of gephyrin.

Evaluation of the differences between biofilm and planktonic Brucella abortus via metabolomics and proteomics - Taishan Tang; Ye Xu; Jianfeng Wang; Xiao Tan; Xiaona Zhao; Ping Zhou; Fande Kong; Changqing Zhu; Chengping Lu; Huixing Lin (Functional & Integrative Genomics, 2021)

Human papillomavirus prevalence among men who have sex with men in China: a systematic review and meta-analysis - Yiguo Zhou; Yi-Fan Lin; Lei Gao; Jianghong Dai; Ganfeng Luo; Lanying Li; Tanwei Yuan; Peiyang Li; Yuewei Zhan; Yanxiao Gao; Huachun Zou (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Spatial-temporal characteristics of urban air pollution in 337 Chinese cities and their influencing factors - De Zhou; Zhulu Lin; Liming Liu; Jialing Qi (Environmental Science and Pollution Research, 2021)

Identification of three seagrass species in coral reef ecosystem by using multiple genes of DNA barcoding - Xiancheng Lin; Junde Dong; Qingsong Yang; Weiguo Zhou; Yan Wang; Ying Zhang; Manzoor Ahmad; Yingting Sun; Youshao Wang; Juan Ling (Ecotoxicology, 2021)

Activation of Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) with Lidocaine Provokes Pyroptosis of Glioblastoma Cells - B. Zhou; Y. Lin; S. Chen; J. Cai; Z. Luo; S. Yu; J. Lu (Bulletin of Experimental Biology and Medicine, 2021)

Effects of mutual grafting Solanum photeinocarpum from two ecosystems on physiology and selenium absorption of their offspring under selenium stress - Kewen Huang; Yan Wang; Xiaohan Wei; Yuhui Bie; Huixuan Zhou; Lili Deng; Lijin Lin; Ming’an Liao (Acta Physiologiae Plantarum, 2021)

N6-methyladenine DNA Demethylase ALKBH1 Regulates Mammalian Axon Regeneration - Qiao Li; Cheng Qian; Harry Feng; Tyger Lin; Qingsan Zhu; Ying Huang; Feng-Quan Zhou (Neuroscience Bulletin, 2021)

Serum macrophage migration inhibitory factor as a potential biomarker to evaluate therapeutic response in patients with allergic asthma: an exploratory study - Huiyuan Zhu; Shaochun Yan; Jingshuo Wu; Zhong Zhang; Xiaolin Li; Zheng Liu; Xing Ma; Lina Zhou; Lin Zhang; Mingming Feng; Yiwei Geng; Aixin Zhang; et al. (Journal of Zhejiang University-SCIENCE B, 2021)

Al-PHOSLOCK thin-layer capping to control phosphorus release from sediment: effect of hydraulic retention time and phosphorus migration/transformation mechanism - Canyang Lin; Shuwen Li; Bolin Zhu; Shupo Liu; Fei Li; Zhenming Zhou; Tao Li (Journal of Soils and Sediments, 2021)

Safety and efficacy of new oral anticoagulants compared to those of warfarin in AF patients with cancer: a meta-analysis of randomized clinical trials and observational studies - Yueming Chen; Min Mao; Jing Chang; Jing Yan; Tiantian Yang; Yang Liu; Meng Luo; Yuhao Hu; Qi Yang; Lin Zhou; Kanghua Ma (European Journal of Clinical Pharmacology, 2021)

Combining ability and genetic diversity under low-temperature conditions at germination stage of maize (Zea mays L.) - Jiayue Zhang; Yichen Li; Ziwen Zhang; Hong Di; Lin Zhang; Xuerui Wang; Zhenhua Wang; Yu Zhou (Euphytica, 2021)

Trueperella pyogenes pyolysin inhibits lipopolysaccharide-induced inflammatory response in endometrium stromal cells via autophagy- and ATF6-dependent mechanism - Maozhen Qi; Jianguo Liu; Qingran Jiang; Hongyu Niu; Xinyu Wang; Dong Zhou; Pengfei Lin; Huatao Chen; Aihua Wang; Yaping Jin (Brazilian Journal of Microbiology, 2021)

Quantitative characterization of horizontal well production performance with multiple indicators: a case study on the Weiyuan shale gas field in the Sichuan Basin, China - Rongze Yu; Wei Guo; Lin Ding; Meizhu Wang; Feng Cheng; Xiaowei Zhang; Shangwen Zhou; Leifu Zhang (Frontiers of Earth Science, 2021)

Potential benefits of liming to acid soils on climate change mitigation and food security - Yan Wang; Zhisheng Yao; Yang Zhan; Xunhua Zheng; Minghua Zhou; Guangxuan Yan; Lin Wang; Christian Werner; Klaus Butterbach‐Bahl (Global Change Biology, 2021)
Globally, about 50% of all arable soils are classified as acidic. As crop and plant growth are significantly hampered under acidic soil conditions, many farmers, but increasingly as well forest managers, apply lime to raise the soil pH. Besides its direct effect on soil pH, liming also affects soil C and nutrient cycles and associated greenhouse gas (GHG) fluxes. In this meta‐analysis, we reviewed 1570 observations reported in 121 field‐based studies worldwide, to assess liming effects on soil GHG fluxes and plant productivity. We found that liming significantly increases crop yield by 36.3%. Also, soil organic C (SOC) stocks were found to increase by 4.51% annually, though soil respiration is stimulated too (7.57%). Moreover, liming was found to reduce soil N 2 O emission by 21.3%, yield‐scaled N 2 O emission by 21.5%, and CH 4 emission and yield‐scaled CH 4 emission from rice paddies by 19.0% and 12.4%, respectively. Assuming that all acid agricultural soils are limed periodically, liming results in a total GHG balance benefit of 633−749 Tg CO 2 ‐eq year −1 due to reductions in soil N 2 O emissions (0.60−0.67 Tg N 2 O‐N year −1 ) and paddy soil CH 4 emissions (1.75−2.21 Tg CH 4 year −1 ) and increases in SOC stocks (65.7–110 Tg C year −1 ). However, this comes at the cost of an additional CO 2 release (c. 624–656 Tg CO 2 year −1 ) deriving from lime mining, transport and application, and lime dissolution, so that the overall GHG balance is likely neutral. Nevertheless, liming of acid agricultural soils will increase yields by at least 6.64 × 10 8 Mg year −1 , covering the food supply of 876 million people. Overall, our study shows for the first time that a general strategy of liming of acid agricultural soils is likely to result in an increasing sustainability of global agricultural production, indicating the potential benefit of liming acid soils for climate change mitigation and food security.

Photoperiod decelerates the advance of spring phenology of six deciduous tree species under climate warming - Lin Meng; Yuyu Zhou; Lianhong Gu; Andrew D. Richardson; Josep Peñuelas; Yongshuo Fu; Yeqiao Wang; Ghasserm R. Asrar; Hans J. De Boeck; Jiafu Mao; Yongguang Zhang; Zhuosen Wang (Global Change Biology, 2021)
Vegetation phenology in spring has substantially advanced under climate warming, consequently shifting the seasonality of ecosystem process and altering biosphere–atmosphere feedbacks. However, whether and to what extent photoperiod (i.e., daylength) affects the phenological advancement is unclear, leading to large uncertainties in projecting future phenological changes. Here we examined the photoperiod effect on spring phenology at a regional scale using in situ observation of six deciduous tree species from the Pan European Phenological Network during 1980–2016. We disentangled the photoperiod effect from the temperature effect (i.e., forcing and chilling) by utilizing the unique topography of the northern Alps of Europe (i.e., varying daylength but uniform temperature distribution across latitudes) and examining phenological changes across latitudes. We found prominent photoperiod‐induced shifts in spring leaf‐out across latitudes (up to 1.7 days per latitudinal degree). Photoperiod regulates spring phenology by delaying early leaf‐out and advancing late leaf‐out caused by temperature variations. Based on these findings, we proposed two phenological models that consider the photoperiod effect through different mechanisms and compared them with a chilling model. We found that photoperiod regulation would slow down the advance in spring leaf‐out under projected climate warming and thus mitigate the increasing frost risk in spring that deciduous forests will face in the future. Our findings identify photoperiod as a critical but understudied factor influencing spring phenology, suggesting that the responses of terrestrial ecosystem processes to climate warming are likely to be overestimated without adequately considering the photoperiod effect.

Divergent above‐ and below‐ground biodiversity pathways mediate disturbance impacts on temperate forest multifunctionality - Zuoqiang Yuan; Arshad Ali; Michel Loreau; Fang Ding; Shufang Liu; Anvar Sanaei; Wangming Zhou; Ji Ye; Fei Lin; Shuai Fang; Zhanqing Hao; Xugao Wang; et al. (Global Change Biology, 2021)
Biodiversity plays a fundamental role in provisioning and regulating forest ecosystem functions and services. Above‐ground (plants) and below‐ground (soil microbes) biodiversity could have asynchronous change paces to human‐driven land‐use impacts. Yet, we know very little how they affect the provision of multiple forest functions related to carbon accumulation, water retention capacity and nutrient cycling simultaneously (i.e. ecosystem multifunctionality; EMF). We used a dataset of 22,000 temperate forest trees from 260 plots within 11 permanent forest sites in Northeastern China, which are recovering from three post‐logging disturbances. We assessed the direct and mediating effects of multiple attributes of plant biodiversity (taxonomic, phylogenetic, functional and stand structure) and soil biodiversity (bacteria and fungi) on EMF under the three disturbance levels. We found the highest EMF in highly disturbed rather than undisturbed mature forests. Plant taxonomic, phylogenetic, functional and stand structural diversity had both positive and negative effects on EMF, depending on how the EMF index was quantified, whereas soil microbial diversity exhibited a consistent positive impact. Biodiversity indices explained on average 45% (26%–58%) of the variation in EMF, whereas climate and disturbance together explained on average 7% (0.4%–15%). Our result highlighted that the tremendous effect of biodiversity on EMF, largely overpassing those of both climate and disturbance. While above‐ ( β = 0.02–0.19) and below‐ground ( β = 0.16–0.26) biodiversity had direct positive effects on EMF, their opposite mediating effects ( β = −0.22 vs. β = 0.35 respectively) played as divergent pathways to human disturbance impacts on EMF. Our study sheds light on the need for integrative frameworks simultaneously considering above‐ and below‐ground attributes to grasp the global picture of biodiversity effects on ecosystem functioning and services. Suitable management interventions could maintain both plant and soil microbial biodiversity, and thus guarantee a long‐term functioning and provisioning of ecosystem services in an increasing disturbance frequency world.

Initiation of efficient C 4 pathway in response to low ambient CO 2 during the bloom period of a marine dinoflagellate - Hao Zhang; Youping Zhou; Tian‐Qi Liu; Xi‐Jie Yin; Lin Lin; Qiang Lin; Da‐Zhi Wang (Environmental Microbiology, 2021)
Summary Dinoflagellates are important primary producers and major causative agents of harmful algal blooms in the global ocean. Despite the great ecological significance, the photosynthetic carbon acquisition by dinoflagellates is still poorly understood. The pathways of photosynthetic carbon assimilation in a marine dinoflagellate Prorocentrum donghaiense under both in situ and laboratory‐simulated bloom conditions were investigated using a combination of metaproteomics, qPCR, stable carbon isotope and targeted metabolomics approaches. A rapid consumption of dissolved CO 2 to generate high biomass was observed as the bloom proceeded. The carbon assimilation genes and proteins including intracellular carbonic anhydrase 2, phosphoenolpyruvate carboxylase, phosphoenolpyruvate carboxykinase and RubisCO as well as their enzyme activities were all highly expressed at the low CO 2 level, indicating that C 4 photosynthetic pathway functioned in the blooming P . donghaiense cells. Furthermore, δ 13 C values and content of C 4 compound (malate) significantly increased with the decreasing CO 2 concentration. The transition from C 3 to C 4 pathway minimizes the internal CO 2 leakage and guarantees efficient carbon fixation at the low CO 2 level. This study demonstrates the existence of C 4 photosynthetic pathway in a marine dinoflagellate and reveals its important complementary role to assist carbon assimilation for cell proliferation during the bloom period.

Impact factors of the accumulation, migration and spread of antibiotic resistance in the environment - Zibo Lin; Tao Yuan; Lai Zhou; Sen Cheng; Xu Qu; Ping Lu; Qiyan Feng (Environmental Geochemistry and Health, 2021)

Dynamics of the spatiotemporal morphology of Mei-yu fronts: an initial survey - Yang Hu; Yi Deng; Yanluan Lin; Zhimin Zhou; Chunguang Cui; Xiquan Dong (Climate Dynamics, 2021)
Mei-yu fronts are often accompanied with prominent diabatic heating due to the development of frontal clouds and rain bands. The direct effect and relative importance of diabatic heating on the spatiotemporal morphology of Mei-yu fronts however remain unclear. Here a new frontogenesis function is derived to isolate the effect of diabatic heating and this function is then applied to the latest high resolution reanalysis product ERA5 to conduct an initial survey of dynamic and thermodynamic processes driving the intensity and structure evolutions of three typical Mei-yu fronts. It is found that the direct effect of latent heating (moisture depletion) is always frontogenetical (frontolytical) in the pre-frontal and frontal zone throughout the lifecycle of the front with latent heating (moisture depletion) in general dominates the front intensification (dissipation). Tilting is another critical process that turns the vertical gradient of equivalent potential temperature into horizontal gradient leading to frontogenesis during the front development stage, and, after the release of convective instability ahead of the front, flattens the front surface leading to frontolysis during the front decaying stage. Therefore titling maintains consistently positive contributions to the evolution of a Mei-yu front and its importance depends highly on the convective intensity near the front. The deformation effect appears frontogenetical but carries a much smaller weight compared to diabatic heating, moisture depletion and tilting. The structure evolutions of the three Mei-yu fronts studied here exhibit two distinct patterns: “bending and breaking”, and “moving and rotating”. Both patterns are dominated by the front propagation (i.e., frontogenesis through air parcels), further highlighting the critical roles played by diabatic heating, moisture depletion and titling in determining the spatiotemporal characteristics of Mei-yu fronts. As these three processes are all closely tied to updrafts, clouds and precipitation near the fronts, improved representations of clouds and convection are needed to accurately depict their feedbacks to frontal evolutions and ultimately achieve better predictions of heavy rainfall and floods associated with Mei-yu fronts.

Exposed to Mercury-Induced Oxidative Stress, Changes of Intestinal Microflora, and Association between them in Mice - Yulan Zhao; Changming Zhou; Xiaoquan Guo; Guoliang Hu; Guyue Li; Yu Zhuang; Huabin Cao; Lin Li; Chonghong Xing; Caiying Zhang; Fan Yang; Ping Liu (Biological Trace Element Research, 2021)

Cryostructures and ground ice content in ice-rich permafrost area of the Qinghai-Tibet Plateau with Computed Tomography Scanning - Xing-wen Fan; Zhan-ju Lin; Ze-yong Gao; Xiang-lian Meng; Fu-jun Niu; Jing Luo; Guo-an Yin; Fu-jun Zhou; Ai-yu Lan (Journal of Mountain Science, 2021)

Study on characteristics of waterflooding in fractured reservoirs based on discrete fracture model - Fanle Meng; Junjian Li; Hanqiao Jiang; Lin Zhao; Linkai Li; Yan Qiao; Yu Zhou; Fei Xu (Arabian Journal of Geosciences, 2021)

Variations in melt supply along an orthogonal supersegment of the Southwest Indian Ridge (16°–25°E) - Caicai Zha; Jian Lin; Zhiyuan Zhou; Xubo Zhang; Min Xu; Fan Zhang (Acta Oceanologica Sinica, 2021)

Mortality burden caused by diurnal temperature range: a nationwide time-series study in 364 Chinese locations - Min Cai; Jianxiong Hu; Chunliang Zhou; Zhulin Hou; Yanjun Xu; Maigeng Zhou; Yize Xiao; Biao Huang; Xiaojun Xu; Lifeng Lin; Tao Liu; Jianpeng Xiao; et al. (Stochastic Environmental Research and Risk Assessment, 2021)

Structure of SARS-CoV-2 main protease in the apo state - Xuelan Zhou; Fanglin Zhong; Cheng Lin; Xiaohui Hu; Yan Zhang; Bing Xiong; Xiushan Yin; Jinheng Fu; Wei He; Jingjing Duan; Yang Fu; Huan Zhou; et al. (Science China Life Sciences, 2021)

Protein kinase PpCIPK1 modulates plant salt tolerance in Physcomitrella patens - Fei Xiao; Xiaochuan Li; Jiaxian He; Jinfeng Zhao; Guochun Wu; Qianyuan Gong; Huapeng Zhou; Honghui Lin (Plant Molecular Biology, 2021)

Selective Ferroptosis Inhibitor Liproxstatin-1 Attenuates Neurological Deficits and Neuroinflammation After Subarachnoid Hemorrhage - Yang Cao; Yin Li; Chao He; Feng Yan; Jian-Ru Li; Hang-Zhe Xu; Jian-Feng Zhuang; Hang Zhou; Yu-Cong Peng; Xiong-Jie Fu; Xiao-Yang Lu; Yuan Yao; et al. (Neuroscience Bulletin, 2021)

GTree: an Open-source Tool for Dense Reconstruction of Brain-wide Neuronal Population - Hang Zhou; Shiwei Li; Anan Li; Qing Huang; Feng Xiong; Ning Li; Jiacheng Han; Hongtao Kang; Yijun Chen; Yun Li; Huimin Lin; Yu-Hui Zhang; et al. (Neuroinformatics, 2021)

Phylogeny and taxonomy of two new Alternaria (Ascomycota: Pleosporaceae) species in section Gypsophilae from China - Lin He; Hong Cheng; Aye Aye Htun; Hui Ge; Zhen Zhou Xia; Jian Wei Guo; Jian Xin Deng; Tao Du (Mycological Progress, 2021)

ZEB1: New advances in fibrosis and cancer - Lin Cheng; Ming-Yuan Zhou; Ying-Jian Gu; Lei Chen; Yun Wang (Molecular and Cellular Biochemistry, 2021)

Activating Transcription Factor 6 Contributes to Functional Recovery After Spinal Cord Injury in Adult Zebrafish - Zhe Ji; Zhi-Lan Zhou; Qin Hao; Lin Zhao; Chun Cui; Shu-Bing Huang; Yan-Ling Yang; Yan-Qin Shen (Journal of Molecular Neuroscience, 2021)

The effect of secondary capping on the control of phosphorus release from sediment by activated thin-layer capping with Al-PIA - Bolin Zhu; Shuwen Li; Canyang Lin; Shupo Liu; Fei Li; Zhenming Zhou (Environmental Science and Pollution Research, 2021)

Rhizosphere microbiome dynamics in tropical seagrass under short-term inorganic nitrogen fertilization - Weiguo Zhou; Junde Dong; Dewen Ding; Lijuan Long; Anning Suo; Xiancheng Lin; Qingsong Yang; Liyun Lin; Yanying Zhang; Juan Ling (Environmental Science and Pollution Research, 2021)

Marinobacter shengliensis subsp. alexandrii Subsp. Nov., Isolated from Cultivable Phycosphere Microbiota of Highly Toxic Dinoflagellate Alexandrium catenella LZT09 and Description of Marinobacter shengliensis Subsp. shengliensis Subsp. Nov - Xi Yang; Rong Xiang; Nurhezreen Md Iqbal; Yu-Han Duan; Xiao-Ai Zhang; Lei Wang; Lin-Zeng Yu; Jia-Zhou Li; Ming-Fei Sun; Qiao Yang; Chun-Tian Zheng; Shen-Quan Liao (Current Microbiology, 2021)

Abberant inverted U-shaped brain pattern and trait-related retinal impairment in schizophrenia patients with combined auditory and visual hallucinations: a pilot study - Chuanjun Zhuo; Bo Xiao; Ce Chen; Deguo Jiang; Gongying Li; Xiaoyan Ma; Ranli Li; Lina Wang; Yong Xu; Chunhua Zhou; Xiaodong Lin (Brain Imaging and Behavior, 2021)
Schizophrenic patients often experience auditory hallucinations (AHs) and visual hallucinations (VHs). However, brain and retinal alterations associated with combined AHs and VHs in schizophrenic patients are unknown. This study aimed o investigate brain and retinal alterations in first episode un-treated schizophrenic patients with combined AHs and VHs (FUSCHAV). FUSCHAV patients ( n = 120), divided into four groups according to severity of AH and VH symptoms, were compared to healthy controls ( n = 30). Gray matter volume (GMV) and global functional connectivity density (gFCD) were recorded to reflect brain structure and functional alterations. Total retinal thickness was acquired by optical coherence tomography to assess retinal impairment. The majority of FUSCHAV patients (85.8%) demonstrated both GMV reduction and gFCD increases along with retinal thinning compared to healthy controls. The severity of GMV reduction and gFCD increase differed between patient groups, ranked from highest to lowest severity as follows: severe AHs combined with severe VHs (FUSCHSASV, 20 patients), moderate AHs combined with severe VHs (FUSCHMASV, 23 patients), severe AHs combined with moderate VHs (FUSCHSAMV, 28 patients), and moderate AHs combined with moderate VHs (FUSCHMAMV, 26). Retinal impairment was similar among the four FUSCHAV groups. GMV reduction and gFCD increases in the frontal-parietal lobule show an inverted U-shaped pattern among FUSCHAV patients according to AH and VH severity, while retinal impairment remains stable among FUSCHAV groups. These findings indicate a reciprocal deterioration in auditory and visual disturbances among FUSCHAV patients.

DNAH17 is essential for rat spermatogenesis and fertility - Liling Chen; Jiamin Ouyang; Xueqing Li; Xueshan Xiao; Wenmin Sun; Shiqiang Li; Lin Zhou; Yuandong Liao; Qingjiong Zhang (Journal of Genetics, 2021)

The molecular mechanism of a novel derivative of BTO-956 induced apoptosis in human myelomonocytic lymphoma cells - Yu-Lin Li; De-Jun Zhou; Zheng-Guo Cui; Lu Sun; Qian-Wen Feng; Shahbaz Ahmad Zakki; Yusuke Hiraku; Cheng-Ai Wu; Hidekuni Inadera (Apoptosis, 2021)

Air-pollutant mass concentration changes during COVID-19 pandemic in Shanghai, China - Zhi Niu; Tingting Hu; Lin Kong; Wenqi Zhang; Pinhua Rao; Dafeng Ge; Mengge Zhou; Yuseng Duan (Air Quality, Atmosphere & Health, 2021)

Cytotoxicity of polyketides and steroids isolated from the sponge-associated fungus Penicillium citrinum SCSIO 41017 - Limbadri Salendra; Xiuping Lin; Weihao Chen; Xiaoyan Pang; Xiaowei Luo; Jieyi Long; Shengrong Liao; Junfeng Wang; Xuefeng Zhou; Yonghong Liu; Bin Yang (Natural Product Research, 2021)

Megafaunal Community Structure From the Abyssal to Hadal Zone in the Yap Trench - Dongsheng Zhang; Yadong Zhou; Jichao Yang; Thomas Linley; Ruiyan Zhang; Bo Lu; Peng Xu; Chengcheng Shen; Shiquan Lin; Yueyun Wang; Dong Sun; Xiaogu Wang; et al. (Frontiers in Marine Science, 2021)
Hadal trenches remain one of the unexplored ocean ecosystems due to the challenges of sampling at great depths. It is still unclear how a faunal community changes from the abyssal to the hadal zone, and which environmental variables are the key impacting factors. In this study, nine dives of the Human Occupied Vehicle (HOV) “ JIAOLONG ” were conducted from abyssal to hadal depths (4,435–6,796 m) in the Yap Trench on the southeastern boundary of the Philippine Sea Plate in the western Pacific, divided into 48,200 m video transects, to describe the megafaunal communities and reveal their relationship with environmental factors. A total of 1,171 megafauna organisms was recorded, 80 morphospecies (msps) from 8 phyla were identified based on the video data, most of which were reported for the first time in the Yap Trench. Arthropoda was the most abundant phylum and Echinodermata was the most diverse phylum of the megafaunal community. The faunal abundance increased with depth, whereas the Shannon diversity index decreased with depth. Cluster analysis suggested seven assemblages, with five abyssal groups, one mixed group, and one hadal dominant group. Although megafaunal communities changed gradually from abyssal zone to hadal zone, both PERMANOVA and PERMDISP analyses revealed that the communities are significantly different between abyssal zone and hadal zone, indicating 6,000 m as the boundary between the two depth zones. Depth, substrate, slope, and latitude were identified as four important environmental factors with significant influence on megafaunal community structure. This study proposed a transition pattern from the abyssal to hadal zone in the Yap Trench, highlighted the importance of habitat heterogeneity in structuring megafaunal community in a hadal trench.

Not vegetation itself but mis-revegetation reduces water resources - Guoyi Zhou; Jun Xia; Ping Zhou; Tingting Shi; Lin Li (Science China Earth Sciences, 2021)

TRIC-A regulates intracellular Ca2+ homeostasis in cardiomyocytes - Xinyu Zhou; Ang Li; Pei-hui Lin; Jingsong Zhou; Jianjie Ma (Pflügers Archiv - European Journal of Physiology, 2021)
Trimeric intracellular cation (TRIC) channels have been identified as monovalent cation channels that are located in the ER/SR membrane. Two isoforms discovered in mammals are TRIC-A (TMEM38a) and TRIC-B (TMEM38b). TRIC-B ubiquitously expresses in all tissues, and TRIC-B −/− mice is lethal at the neonatal stage. TRIC-A mainly expresses in excitable cells. TRIC-A −/− mice survive normally but show abnormal SR Ca 2+ handling in both skeletal and cardiac muscle cells. Importantly, TRIC-A mutations have been identified in human patients with stress-induced arrhythmia. In the past decade, important discoveries have been made to understand the structure and function of TRIC channels, especially its role in regulating intracellular Ca 2+ homeostasis. In this review article, we focus on the potential roles of TRIC-A in regulating cardiac function, particularly its effects on intracellular Ca 2+ signaling of cardiomyocytes and discuss the current knowledge gaps.

Simulation of the fragmentation and propagation of jointed rock masses in rockslides: DEM modeling and physical experimental verification - Qi-wen Lin; Qian-Gong Cheng; Yu Xie; Feng-shou Zhang; Kun Li; Yu-feng Wang; Yuan-yuan Zhou (Landslides, 2021)

Spatial-temporal characteristics and influencing factors of atmospheric environmental efficiency in China - Xiaowei Ma; Xin Zhao; Lin Zhang; Yuanxiang Zhou; Huangxin Chen (Environmental Science and Pollution Research, 2021)

Prediction models of pulp components based on the quality indices in bleaching process - Zhichao Ma; Shaoxu Chen; Yongjun Yin; Xiaodan Lu; Yanying Zhou; Tingting Lin (Environment, Development and Sustainability, 2021)

Effects of Grazing, Wind Erosion, and Dust Deposition on Plant Community Composition and Structure in a Temperate Steppe - Mengmei Zheng; Jian Song; Jingyi Ru; Zhenxing Zhou; Mingxing Zhong; Lin Jiang; Dafeng Hui; Shiqiang Wan (Ecosystems, 2021)

Classification of Northeast China Cold Vortex Activity Paths in Early Summer Based on K-means Clustering and Their Climate Impact - Yihe Fang; Haishan Chen; Yi Lin; Chunyu Zhao; Yitong Lin; Fang Zhou (Advances in Atmospheric Sciences, 2021)

Experimental Investigation of CS2 Extraction to Enhance the Permeability of Coal - Zhen Zhang; Gaofeng Liu; Yunxing Cao; Jia Lin; Yi Jin; Baoan Xian; Runsheng Lv; Zhou Zhang (Transport in Porous Media, 2021)

Correction to: A Chromosomal-scale Reference Genome of the Kelp Grouper Epinephelus moara - Qian Zhou; Haoyang Gao; Hao Xu; Haoran Lin; Songlin Chen (Marine Biotechnology, 2021)

Genome-Wide Association Study Identifies Genomic Loci of Sex Determination and Gonadosomatic Index Traits in Large Yellow Croaker (Larimichthys crocea) - Huanling Lin; Zhixiong Zhou; Ji Zhao; Tao Zhou; Huaqiang Bai; Qiaozhen Ke; Fei Pu; Weiqiang Zheng; Peng Xu (Marine Biotechnology, 2021)

A Chromosomal-scale Reference Genome of the Kelp Grouper Epinephelus moara - Qian Zhou; Haoyang Gao; Hao Xu; Haoran Lin; Songlin Chen (Marine Biotechnology, 2021)

First report of natural infection of tomato by pepper mild mottle virus in China - Wen Peng Zhou; Yue Yue Li; Fan Li; Guan Lin Tan (Journal of Plant Pathology, 2021)

NLRP3 inflammasome priming and activation in cholestatic liver injury via the sphingosine 1-phosphate/S1P receptor 2/Gα(12/13)/MAPK signaling pathway - Lei Hou; Zhi Zhang; Le Yang; Na Chang; Xinhao Zhao; Xuan Zhou; Lin Yang; Liying Li (Journal of Molecular Medicine, 2021)

Assisted selection of eating quality progeny of indica (O. sativa L. ssp. indica) and japonica (O. sativa L. ssp. japonica) hybrids using rice starch properties - Ting Mao; Zhan Zhang; Shan Jun Ni; Yi Zhou Zhao; Xin Li; Li Li Zhang; Yan Liu; Cheng Shun Zhong; He Huang; Shao Lin Wang; Xu Li (Genetic Resources and Crop Evolution, 2021)

Direct Calculation Method for the Analysis of Non-linear Behavior of Ground-Support Interaction of a Circular Tunnel Using Convergence Confinement Approach - Yu-Lin Lee; Wen-Kuei Hsu; Chi-Min Lee; Yi-Xian Xin; Bo-Yu Zhou (Geotechnical and Geological Engineering, 2021)

Injection route affects intra-articular hyaluronic acid distribution and clinical outcome in viscosupplementation treatment for knee osteoarthritis: a combined cadaver study and randomized clinical trial - Jun Xiao; Yong Hu; Lin Huang; Zhi-Fa Huang; Wei-Zhou Jiang; Yu-Qiang Luo; Meng-Yan Jia; Di Chen; Zhan-Jun Shi (Drug Delivery and Translational Research, 2021)

The contrasting effects of thermodynamic and dynamic processes on East Asian summer monsoon precipitation during the Last Glacial Maximum: a data-model comparison - Yong Sun; Haibin Wu; Masa Kageyama; Gilles Ramstein; Laurent Z. X. Li; Ning Tan; Yating Lin; Bo Liu; Weipeng Zheng; Wenchao Zhang; Liwei Zou; Tianjun Zhou (Climate Dynamics, 2021)
The Last Glacial Maximum (LGM; 21 ka BP) was the most recent glacial period when the global ice sheet volume was at a maximum. Therefore, the LGM can be used to investigate atmospheric dynamics under a climate that differed significantly from the present. This study quantitatively compares pollen records of boreal summer (June–July–August) precipitation with the PMIP3 LGM simulations. The data-model comparison shows an overall agreement on a drier than pre-industrial East Asian summer monsoon (EASM) climate. Nevertheless, 17 out of 55 records show a regional precipitation increase that is also simulated over the additional land mass area due to sea level drop. The thermodynamic and dynamic responses are analyzed to explain a drier LGM EASM as a combination of these two antagonistic mechanisms. Relatively low atmospheric moisture content was the main thermodynamic control on the lower LGM (relative to pre-industrial levels) EASM precipitation amounts in both the reconstructions and the models. In contrast, two dynamic processes in relation to stationary eddy activity act to increase EASM precipitation regionally in records and simulations, respectively. Precipitation increase in records is explained by dynamic enhancement of the horizontal moisture transport, while dynamic enhancement of the vertical moisture transport leads to simulated precipitation increase over the specific region where landmass was exposed during LGM along continental coastlines of China due to significant drop in sea level (relative to pre-industrial levels). Overall, the opposing effects of thermodynamic and dynamic processes on precipitation during the LGM provide a means to reconcile the spatial heterogeneity of recorded precipitation changes in sign, although data-model comparison suggests that the simulated dynamic wetting mechanism is too weak relative to the thermodynamic drying mechanism over data-model disagreement regions.

Sex-specific effects of cigarette smoking on caudate and amygdala volume and resting-state functional connectivity - Fuchun Lin; Xu Han; Yao Wang; Weina Ding; Yawen Sun; Yan Zhou; Hao Lei (Brain Imaging and Behavior, 2021)

Transcriptome and Metabolome Analyses of Sea Cucumbers Apostichopus japonicus in Southern China During the Summer Aestivation Period - Qiuhua Yang; Xusheng Zhang; Zhen Lu; Ruifang Huang; Ngoc Tuan Tran; Jianshao Wu; Fuyuan Yang; Hui Ge; Chenhui Zhong; Qian Sun; Chen Zhou; Qi Lin (Journal of Ocean University of China, 2021)

CAS-ESM2.0 Model Datasets for the CMIP6 Flux-Anomaly-Forced Model Intercomparison Project (FAFMIP) - Jiangbo Jin; He Zhang; Xiao Dong; Hailong Liu; Minghua Zhang; Xin Gao; Juanxiong He; Zhaoyang Chai; Qingcun Zeng; Guangqing Zhou; Zhaohui Lin; Yi Yu; et al. (Advances in Atmospheric Sciences, 2021)
The second version of the Chinese Academy of Sciences Earth System Model (CAS-ESM2.0) is participating in the Flux-Anomaly-Forced Model Intercomparison Project (FAFMIP) experiments in phase 6 of the Coupled Model Intercomparison Project (CMIP6). The purpose of FAFMIP is to understand and reduce the uncertainty of ocean climate changes in response to increased CO 2 forcing in atmosphere-ocean general circulation models (AOGCMs), including the simulations of ocean heat content (OHC) change, ocean circulation change, and sea level rise due to thermal expansion. FAFMIP experiments (including faf-heat, faf-stress, faf-water, faf-all, faf-passiveheat, faf-heat-NA50pct and faf-heat-NA0ct) have been conducted. All of the experiments were integrated over a 70-year period and the corresponding data have been uploaded to the Earth System Grid Federation data server for CMIP6 users to download. This paper describes the experimental design and model datasets and evaluates the preliminary results of CAS-ESM2.0 simulations of ocean climate changes in the FAFMIP experiments. The simulations of the changes in global ocean temperature, Atlantic Meridional Overturning Circulation (AMOC), OHC., and dynamic sea level (DSL), are all reasonably reproduced.

CAS-ESM2.0 Model Datasets for the CMIP6 Ocean Model Intercomparison Project Phase 1 (OMIP1) - Xiao Dong; Jiangbo Jin; Hailong Liu; He Zhang; Minghua Zhang; Pengfei Lin; Qingcun Zeng; Guangqing Zhou; Yongqiang Yu; Mirong Song; Zhaohui Lin; Ruxu Lian; et al. (Advances in Atmospheric Sciences, 2021)
As a member of the Chinese modeling groups, the coupled ocean-ice component of the Chinese Academy of Sciences’ Earth System Model, version 2.0 (CAS-ESM2.0), is taking part in the Ocean Model Intercomparison Project Phase 1 (OMIP1) experiment of phase 6 of the Coupled Model Intercomparison Project (CMIP6). The simulation was conducted, and monthly outputs have been published on the ESGF (Earth System Grid Federation) data server. In this paper, the experimental dataset is introduced, and the preliminary performances of the ocean model in simulating the global ocean temperature, salinity, sea surface temperature, sea surface salinity, sea surface height, sea ice, and Atlantic Meridional Overturning Circulation (AMOC) are evaluated. The results show that the model is at quasi-equilibrium during the integration of 372 years, and performances of the model are reasonable compared with observations. This dataset is ready to be downloaded and used by the community in related research, e.g., multi-ocean-sea-ice model performance evaluation and interannual variation in oceans driven by prescribed atmospheric forcing.

Development of a 100 MPa water–gas two-phase fluid pressurization device - Shengbin Li; Heping Li; Lin Chen; Hongbin Zhou (Acta Geochimica, 2021)

Sesquiterpenoids and meroterpenoids from a mangrove derived fungus Diaporthe sp. SCSIO 41011 - Xiao-Wei Luo; Chun-Mei Chen; Kun-Long Li; Xiu-Ping Lin; Cheng-Hai Gao; Xue-Feng Zhou; Yong-Hong Liu (Natural Product Research, 2021)

Triterpenoids from the fresh pericarps of Juglans hopeiensis - Yi Lin; Xiaogang Peng; Juan Chen; Jia Zhou; Hanli Ruan (Natural Product Research, 2021)

Buoyancy Regulation Strategy for Underwater Profiler Based on Adaptive Genetic Algorithm - Hui Zhi; Puzhe Zhou; Yanhu Chen; Xiaoyan Zhao; Yuandong Hong; Mingwei Lin; Canjun Yang (Journal of Marine Science and Engineering, 2021)
Considering the energy limitations of underwater vehicles, a strategy for energy saving is proposed. In the proposed buoyancy regulation strategy, oil of the buoyancy regulation system is pumped out several times at different depths instead of all at once. A balance between energy and time is achieved by assigning suitable weights, and the optimised depth which can be obtained from the pressure sensor is used as the judgement threshold based on the adaptive genetic algorithm. Through the numerical simulation using sea trial data, the influence of weight selection on energy and time is explored, and the frequency of oil draining for the vehicle to ascend is optimised. Simulation results show that the proposed buoyancy regulation strategy can save energy effectively when the frequency of oil draining is 4 times within depths of 0–500 m. Finally, trials were performed in Qiandao Lake and verify the contradictory relationship between energy and time.