Temperature-insensitive conductive composites for noninterference strain sensing - Chao Wu; Fan Lin; Xiaochuan Pan; Yingjun Zeng; Guochun Chen; Lida Xu; Yingping He; Gonghan He; Qinnan Chen; Daoheng Sun; Zhenyin Hai (Chemical Engineering Journal, 2023)

Cu0 incorporated cobalt/nitrogen doped carbonaceous frameworks derived from ZIF-67 (Cu@Co N C) as PMS activator for efficient degradation of naproxen: Direct electron transfer and 1O2 dominated nonradical mechanisms - Jin Zhang; Hanxuan Zeng; Lingjun Bu; Shiqing Zhou; Zhou Shi; Lin Deng (Chemical Engineering Journal, 2023)

Synergistically enhanced structural, thermal and interfacial stability of K0.45MnO2 via tailoring the local structure for high-energy and high-power potassium-ion batteries - Yan Huang; Xinyuan Zhang; Hezhe Lin; Zhixuan Wei; Yi Zeng; Xin Ge; Wei Zhang; Xiaoqi Wang; Xu Jin; Ze Xiang Shen; Fei Du (Chemical Engineering Journal, 2023)

Microbial properties determine dynamics of topsoil organic carbon stocks and fractions along an age-sequence of Mongolian pine plantations - Yansong Zhang; De-Hui Zeng; Zeyong Lei; Xin Li; Guigang Lin (Plant and Soil, 2023)

Integrating Transfer Learning and Feature Aggregation into Self-defined Convolutional Neural Network for Automated Detection of Lung Cancer Bone Metastasis - Yanru Guo; Qiang Lin; Yubo Wang; Xu Cao; Yongchun Cao; Zhengxing Man; Xianwu Zeng; Xiaodi Huang (Journal of Medical and Biological Engineering, 2023)

Observed characteristics of flow, water mass, and turbulent mixing in the Preparis Channel - Ruijie Ye; Feng Zhou; Xiao Ma; Dingyong Zeng; Feilong Lin; Hongliang Li; Chenggang Liu; Soe Moe Lwin; Hlaing Swe Win; Soe Pyae Aung (Acta Oceanologica Sinica, 2023)

Massive nutrients offshore transport off the Changjiang Estuary in flooding summer of 2020 - Qianwen Sun; Dewang Li; Bin Wang; Zhongsheng Xu; Yanyi Miao; Hua Lin; Haiyan Jin; Zhibing Jiang; Jiangning Zeng; Feng Zhou; Jianfang Chen (Frontiers in Marine Science, 2023)
Flood events significantly increase water discharges and terrigenous material inputs to coastal waters. Riverine nutrients in the Changjiang Estuary are transported by the dispersion of Changjiang Diluted Water (CDW) plumes and detached low-salinity water patches. However, the effects of flooding on nutrient offshore transports have not been well explored. Here, we present the nutrient conditions in the Changjiang Estuary and adjacent East China Sea in the historical flooding year 2020. Comparisons of nutrient distributions between flooding years, drought year and non-flooding years were also made. Our results showed that nitrate flux from the Changjiang River in August 2020 was 1.5 times that of the multi-year averaged flux in non-flooding years. Enormous riverine nutrient input resulted in much higher nutrient concentrations in the outer estuary than those in non-flooding years. In addition, a detached low-salinity water patch was observed, which made the salinity of the northern estuary even lower than that in the historical flooding year 1998. Surface dissolved inorganic nitrate (DIN) level in the low-salinity water patch was even ~16 times of that at nearby station in the drought year 2006. While phosphate (PO 4 3− ) concentrations were less than 0.1 μmol L −1 east of 123°E, which was probably caused by intensive biological uptake, as indicated by a high Chlorophyll a (Chl a ) concentration (29.08 μg L −1 ). The depleted PO 4 3− and high N/P of the low-salinity water patch suggested PO 4 3− limitation even under flood conditions. A three end-member mixing model was adopted to identify the contributions of the CDW end-member (CDW end-member ) and biological process to nutrient distributions. Our model results showed that the nutrient contribution of the CDW end-member to the estuary (122–124°E, 31–32.5°N) in flooding year 2020 was over double that in drought year 2006. Model-derived biological DIN uptake was as high as 24.65 μmol L −1 at the low-salinity water patch. Accordingly, the estimated net community production was 566–1131 mg C m −2 d −1 within the euphotic zone. The offshore transport of a low-salinity, high-DIN water patch during flooding could probably have a significant influence on biogeochemical cycles in the broad shelf, and even the adjacent Japan Sea.

Current status of indoor dust PBDE pollution and its physical burden and health effects on children - Keyang Zheng; Zhijun Zeng; Yucong Lin; Qihua Wang; Qianwen Tian; Xia Huo (Environmental Science and Pollution Research, 2023)

RETRACTED ARTICLE: Assessing green financing with emission reduction and green economic recovery in emerging economies - Miaonan Lin; Haorong Zeng; Xin Zeng; Muhammad Mohsin; Syed Mubashar Raza (Environmental Science and Pollution Research, 2023)

Two new cycloartane triterpenoid glycosides from the rhizomes of Actaea vaginata - Shunqin Zeng; Xiangyuan Li; Zixuan Zhao; Yan Lin; Yindi Zhu; Guoxu Ma; Xiaohong Zhao; Xudong Xu; Meichun Wu; Haifeng Wu; Qiongyu Zou; Yongtao Li (Natural Product Research, 2023)

Efficient removal of Sb(III) from water using β-FeOOH-modified biochar:Synthesis, performance and mechanism - Ling Lai; Xitao Liu; Wenbo Ren; Zhou Zhou; Xiwang Zhao; Xiaofeng Zeng; Chunye Lin; Mengchang He; Wei Ouyang (Chemosphere, 2023)

Improving the estimation of canopy structure using spectral invariants: Theoretical basis and validation - Yi Lin; Siyuan Liu; Lei Yan; Kai Yan; Yelu Zeng; Bin Yang (Remote Sensing of Environment, 2023)

Corrigendum to “Comparative efficacy of omega-3 polyunsaturated fatty acids on major cardiovascular events: A network meta-analysis of randomized controlled trials” [Progress in Lipid Research. 2022 Oct 28;88:101196. doi: 10.1016/j.plipres.2022.101196] - Bo Yang; Ping-Tao Tseng; Xiang Hu; Bing-Yan Zeng; Jane Pei-Chen Chang; Yang Liu; Wei-Jie Chu; Shuang-Shuang Zhang; Zhi-Liang Zhou; Chih-Sheng Chu; Cheng-Ho Chang; Yu-Kang Tu; et al. (Progress in Lipid Research, 2023)

Protolith origin of eclogites from the North Qaidam UHP metamorphic Belt, NW China: Implications for the breakup of the Rodinia supercontinent - Xiao-Dong Wang; Lin Ding; Deng Zeng; Ya-Hui Yue; Ling-Ping Yang; Zhe-Jun Wang; Lu-An Xiao; Chao Wang (Precambrian Research, 2023)

Extract of Ginkgo biloba leaves attenuates neurotoxic damages in rats and SH-SY5Y cells exposed to a high level of fluoride - Jie Xiang; Yan-Lin Ma; Jian Zou; Xiao-Xiao Zeng; Xiao Xiao; Yan-Long Yu; Yang-Ting Dong; Long-Yan Ran; Xiao-Lan Qi; Wei Hong; Yan-Hui Gao; Zhi-Zhong Guan (Journal of Trace Elements in Medicine and Biology, 2023)

Glioma is associated with exposure to legacy and alternative per- and polyfluoroalkyl substances - Meng-Yi Xie; Xiang-Fei Sun; Chen-Chou Wu; Guang-Long Huang; Po Wang; Zhi-Ying Lin; Ya-Wei Liu; Liang-Ying Liu; Eddy Y. Zeng (Journal of Hazardous Materials, 2023)

Application of carbon aerogel-based materials in persulfate activation for water treatment: A review - Binbin Shao; Yuantao Xu; Zhifeng Liu; Ting Wu; Yuan Pan; Xiansheng Zhang; Miao He; Lin Ge; Yue Lu; Yang Liu; Weimin Zeng; Lin Tang (Journal of Cleaner Production, 2023)

Organic matter accumulation mechanism under global/regional warming: Insight from the Late Barremian calcareous shales in the Qiangtang Basin (Tibet) - Ying Nie; Xiugen Fu; Xianchuan Liu; Hengye Wei; Shengqiang Zeng; Fei Lin; Youli Wan; Chunyan Song (Journal of Asian Earth Sciences, 2023)

Bridging optical and SAR satellite image time series via contrastive feature extraction for crop classification - Yuan Yuan; Lei Lin; Zeng-Guang Zhou; Houjun Jiang; Qingshan Liu (ISPRS Journal of Photogrammetry and Remote Sensing, 2023)

Insight into the Co2+/Co3+ sites for the selective reduction of furfural to furfuryl alcohol - Jiahong Chen; Wenlong Jia; Xin Yu; Yong Sun; Jiaren Zhang; Shuliang Yang; Xing Tang; Lincai Peng; Xianhai Zeng; Lu Lin (Fuel, 2023)

Insight into the molecular-level details of αs1 casein interactions with IgG: Combining with LC-MS/MS and molecular modelling techniques - Jianhua Zeng; Kai Lin; Xiaoqian Zhang; Junzhe Zou; Lanwei Zhang; Pimin Gong; Jinlong Zhao; Chunhua Han; Yuhai Liu; Huaxi Yi; Tongjie Liu (Food Chemistry, 2023)

The associations of particulate matter short-term exposure and serum lipids are modified by vitamin D status: A panel study of young healthy adults - Jia-Min Li; Han-Yu Yang; Si-Han Wu; Shyamali C. Dharmage; Bin Jalaludin; Luke D. Knibbs; Michael S. Bloom; Yuming Guo; Lidia Morawska; Joachim Heinrich; Yim Steve Hung Lam; Li-Zi Lin; et al. (Environmental Pollution, 2023)

Association between long-term ambient ozone exposure and attention-deficit/hyperactivity disorder symptoms among Chinese children - Peien Zhou; Wangjian Zhang; Yu-Jie Xu; Ru-Qing Liu; Zhengmin Qian; Stephen Edward McMillin; Elizabeth Bingheim; Li-Zi Lin; Xiao-Wen Zeng; Bo-Yi Yang; Li-Wen Hu; Wen Chen; et al. (Environmental Research, 2023)

Occurrence, distribution, and migration of antimony in the Zijiang River around a superlarge antimony deposit zone - Huiji Liu; Wei Zeng; Mengchang He; Chunye Lin; Wei Ouyang; Xitao Liu (Environmental Pollution, 2023)

Sulfate removal from the seawater using single-chamber bioelectrochemical system - Jing Huang; Cuiping Zeng; Haiping Luo; Songwei Lin; Guangli Liu; Renduo Zhang (Desalination, 2023)

Disinfection byproducts formation from emerging organic micropollutants during chlorine-based disinfection processes - Binbin Shao; Leyuan Shen; Zhifeng Liu; Lin Tang; Xiaofei Tan; Dongbo Wang; Weimin Zeng; Ting Wu; Yuan Pan; Xiansheng Zhang; Lin Ge; Miao He (Chemical Engineering Journal, 2023)

Generation of reactive oxygen species through dissolved oxygen activation on defected porous carbon for efficient degradation of antibiotics - Jiaming Liu; Zhangwei Yao; Genping Qiu; Yinhua Wan; Weijie Song; Huifeng Zeng; Feifei Yang; Da Zhao; Wenjing Yuan; Peihai Ju; Ruixi Lin; Hengcheng Zhou; et al. (Chemical Engineering Journal, 2023)

Activation of peroxymonosulfate via peroxyborate: Electrophilic substitution induced strong electrophile generation process - Hanxuan Zeng; Xiao Ling; Jing Deng; Lin Deng; Haojie Zhang; Tao Shi; Shiqing Zhou; Zhou Shi (Chemical Engineering Journal, 2023)

Thin-walled vesicular Triazole-CN-PDI with electronic n→π* excitation and directional movement for enhanced atrazine photodegradation - Rongdi Tang; Hao Zeng; Daoxin Gong; Yaocheng Deng; Sheng Xiong; Ling Li; Zhanpeng Zhou; Jiajia Wang; Chengyang Feng; Lin Tang (Chemical Engineering Journal, 2023)

A Bayesian approach to develop simple run-out distance models: loess landslides in Heifangtai Terrace, Gansu Province, China - Xiaoping Sun; Peng Zeng; Tianbin Li; Lin Zhang; Rafael Jimenez; Xiujun Dong; Qiang Xu (Landslides, 2023)

Rice straw biochar reduces Cd accumulation and promotes Cu accumulation in rice: irrigation regime is the driving factor - Le Chen; Lin Guo; Ping Liao; Qiangqiang Xiong; Xueyun Deng; Hui Gao; Haiyan Wei; Qigen Dai; Xiaohua Pan; Yongjun Zeng; Hongcheng Zhang (Journal of Soils and Sediments, 2023)

Andrographolide ameliorates hepatic steatosis by suppressing FATP2-mediated fatty acid uptake in mice with nonalcoholic fatty liver disease - Li-Sha Ran; Ya-Zeng Wu; Yi-Wen Gan; Hong-Lian Wang; Li-Juan Wu; Chun-Mei Zheng; Yao Ming; Ran Xiong; Yong-Lin Li; Shi-Hang Lei; Xue Wang; Xiao-Qing Lao; et al. (Journal of Natural Medicines, 2023)
Excessive intrahepatocellular lipid accumulation or steatosis is caused by abnormal lipid metabolism and a common character of nonalcoholic fatty liver disease (NAFLD), which may progress into cirrhosis and hepatocellular cancer. Andrographolide (Andro) is the primary active ingredient extracted from Andrographis paniculata , showing a protective role against dietary steatosis with the mechanism not fully understood. In this study, we showed that administration of Andro (50, 100, and 200 mg/kg/day for 8 weeks, respectively) attenuated obesity and metabolic syndrome in high-fat diet (HFD)-fed mice with improved glucose tolerance, insulin sensitivity, and reduced hyperinsulinemia, hyperglycemia, and hyperlipidemia. HFD-fed mice presented hepatic steatosis, which was significantly prevented by Andro. In vitro, Andro decreased the intracellular lipid droplets in oleic acid-treated LO2 cells. The selected RT-PCR array revealed a robust expression suppression of the fatty acid transport proteins (FATPs) by Andro treatment. Most importantly, we found that Andro consistently reduced the expression of FATP2 in both the oleic acid-treated LO2 cells and liver tissues of HFD-fed mice. Overexpression of FATP2 abolished the lipid-lowering effect of Andro in oleic acid-treated LO2 cells. Andro treatment also reduced the fatty acid uptake in oleic acid-treated LO2 cells, which was blunted by FATP2 overexpression. Collectively, our findings reveal a novel mechanism underlying the anti-steatosis effect of Andro by suppressing FATP2-mediated fatty acid uptake, suggesting the potential therapeutic application of Andro in the treatment of NAFLD. Graphical abstract

Tracing the source–sink process of fluvio-clastic materials: Magnetic records of surface sediments in the Yangtze River basin - Xianbin Liu; Jing Chen; Wei Yue; Qing Wang; Chao Zhan; Lin Zeng; Jian Song; Longsheng Wang; Buli Cui (Frontiers in Marine Science, 2022)
In this study, we collected surface sediments from the mainstream and major tributaries of the Yangtze River to systematically analyse their magnetic properties, and discuss the implications for tracing source–sink process of fluvio-clastic materials. Our results showed that the surface sediments from tributaries in the upper basin had a significantly higher content of ferromagnetic minerals and coarser grain sizes than that in the mid-lower basin. The magnetic susceptibility (χ lf ) of surface sediments from the mainstream was 34.16*10 -8 m 3 /kg at Shigu, rapidly rose to 230.56*10 -8 m 3 /kg at Yibin, and then dropped to 68.92*10 -8 m 3 /kg at the river mouth. The χ lf of Yalong River sediments in the upper basin was 276.86*10 -8 m 3 /kg, considerably higher than that of the sediments from other tributaries, and greatly contribute to the χ lf of the sediments in the mainstream, reflecting the dominant constraining role of the Emeishan basalts. The distinctive magnetic properties of the upper core sediments from Jianghan basin and the Yangtze delta closely match those of surficial river sediments of the upper Yangtze basin. This may indicate the addition of clastic materials eroded from the upper basin, resulting from the cut-through of the Three Gorges during the evolution of the Yangtze River that occurred in the late Cenozoic. Investigating the magnetic properties of the surface sediments in the Yangtze River basin can provide insights into the source–sink process of clastic materials and environmental changes.

Enhanced degradation performance of Fe75B12.5Si12.5 amorphous alloys on azo dye - Lin Zhao; Lei Huang; Zhigang Zheng; Jing Wei; Zhaoguo Qiu; Dechang Zeng (Environmental Science and Pollution Research, 2022)

Geomorphologic evolution of the shallow-buried abandoned Yellow River delta during the last 2000 years - Qing Wang; Lin Zeng; Chao Zhan; Xianbin Liu; Longsheng Wang; Shanshan Cheng; Buli Cui (Frontiers in Marine Science, 2022)
Different from the continuous development of many river deltas since the major Holocene transgression, the modern Yellow River delta (YRD) remained for nearly 1000 years (from 893 AD to 1855 AD) in an abandonment state, until after 1855 AD when it was buried after the Yellow River entered the sea via Lijin. In this study we used optically stimulated luminescence (OSL) dating and grain size and sedimentary facies analysis of four borehole cores, combined with an analysis of landform morphology, to reconstruct the history of the ancient abandoned YRD. The results indicate that after the delta was abandoned due to the reduced sediment supply by the Yellow River in 893 AD, a sandy coast developed under the influence of wave erosion, and offshore shell ridges were formed beyond the coastline. During the interval from the Medieval Warm Period (MWP) to the Little Ice Age (LIA), driven by climate change and storm surges, the shell ridges migrated laterally, widened and rose, while sediment accumulation in the landward-side interfluvial floodplains was relatively weak. This configuration subsequently constituted a coastal highland – plain depression system. After 1077 AD, this system, together with the abandoned delta, was eroded by the Daqing River estuary. After 1855 AD, the abandoned delta landform system was completely buried by Yellow River sediments, and the wave-controlled sandy coast was transformed to a tide-controlled silt-mud coast. We summarize these findings in the form of a geomorphic model of the evolution of the abandoned delta from the MWP to the LIA. Overall, our results highlight the geomorphic effects of the sediment-laden river delta and the response of the abandoned delta geomorphic system on the millennial timescale, and they provide a theoretical foundation for predicting the geomorphic evolution of a major river delta on different timescales, against the background of global change.

A Maverick Review of Common Stem/Progenitor Markers in Lung Development - Yijian Lin; Dachun Wang; Yiming Zeng (Stem Cell Reviews and Reports, 2022)

Copper Toxicity Differentially Regulates the Seedling Growth, Copper Distribution, and Photosynthetic Performance of Citrus sinensis and Citrus grandis - Xin-yu Li; Mei-lan Lin; Ping-ping Hu; Ning-wei Lai; Zeng-rong Huang; Li-song Chen (Journal of Plant Growth Regulation, 2022)

Correction to: MiR‑30c‑1‑3p targets matrix metalloproteinase 9 involved in the rupture of abdominal aortic aneurysms - Lin Yang; Hong‑Gang Sui; Meng‑Meng Wang; Jia‑Yin Li; Xiao‑Feng He; Jing‑Yuan Li; Xiao‑Zeng Wang (Journal of Molecular Medicine, 2022)

Whole-genome sequencing and comparative analysis of Helicobacter pylori GZ7 strain isolated from China - Xiaoyan Zeng; Lin Xiong; Wenling Wang; Yan Zhao; Yuan Xie; Qinrong Wang; Qifang Zhang; Leilei Li; Cencen Jia; Yonghui Liao; Jianjiang Zhou (Folia Microbiologica, 2022)

Effect of empirical antifungal treatment on mortality in non-neutropenic critically ill patients: a propensity-matched retrospective cohort study - Yue Tang; Wenjing Hu; Shuangyan Jiang; Maoyu Xie; Wenying Zhu; Lin Zhang; Jing Sha; Tengfei Wang; Min Ding; Juan Zeng; Jinjiao Jiang (European Journal of Clinical Microbiology & Infectious Diseases, 2022)

Study on the Contribution of Seaport to Urban Economy: An Empirical and Quantitative Analysis of Xiamen Port - Wei Liu; Yanbin Yang; Qiaoyun Luo; Xufeng Zeng; Chuxin Chen; Junfeng Zhu; Weishan Lin; Hongbin Chen; Weiwei Huo; Mengxiao He; Yuping Jin; Jiangyu Xu (Journal of Marine Science and Engineering, 2022)
Ports play a vital role in the development of cities. In order to study the contribution of seaports to the urban economy, this paper uses the input–output method and multiplier theory to calculate the direct, indirect, and ripple economic contribution of ports to cities. Then, this paper selects Xiamen Port as an example to calculate the economic contribution. Xiamen Port is a major port on the southeast coast of China and an important node of the 21st Century Maritime Silk Road. It can provide a reference for other port cities. A more detailed index system for evaluating the economic contribution is also constructed. Next, the time series ARIMA model is used to predict the cargo throughput and container throughput of Xiamen Port in the next four years. Finally, there are some suggestions put forward for the development of Xiamen Port. The results show the total economic contribution of Xiamen Port to the city accounted for 10.48% of the city’s GDP in 2017. Direct, indirect, and ripple economic contributions accounted for 2.84%, 2.13%, and 5.51%, respectively. The contribution of Xiamen Port to the city is in line with the growth pole theory, which not only allows for rapid growth in Xiamen Port itself but also drives the development of the entire region through the multiplier effect. The cargo throughput and container throughput of Xiamen Port will maintain continuous growth in the next four years. Therefore, the development of Xiamen Port should be accelerated to enhance its economic contribution to the city.

Study on the chemical composition of Caesalpinia sinensis - Lu-Fen Leng; Qi Lai; Dian Lv; Jun-Lin Yin; Guang-Zhi Zeng (Natural Product Research, 2022)

A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer - Chang Gong; Ziliang Cheng; Yaping Yang; Jun Shen; Yingying Zhu; Li Ling; Wanyi Lin; Zhigang Yu; Zhihua Li; Weige Tan; Chushan Zheng; Wenbo Zheng; et al. (Science China Life Sciences, 2022)

Characterization of phenylalanine hydroxylase gene variants and analysis of genotype–phenotype correlation in patients with phenylalanine hydroxylase deficiency from Fujian Province, Southeastern China - Jinfu Zhou; Yinglin Zeng; Xiaolong Qiu; Qingying Lin; Weifeng Chen; Jinying Luo; Liangpu Xu (Molecular Biology Reports, 2022)
Background Phenylalanine hydroxylase deficiency (PAHD) is the most prevalent inherited disorder of amino acid metabolism in China. Its complex phenotype includes many variants and genotypes among different populations. Methods and results In this study, we analyzed the phenylalanine hydroxylase gene ( PAH ) variants in a cohort of 93 PAHD patients from Fujian Province. We also assessed genotype and phenotype correlation in patients with PAHD. A total of 44 different pathogenic variants were identified, including five novel variants. The three most prevalent variants among all patents were c.158G > A, p.(Arg53His) (18.03%), c.721C > T, p.(Arg241Cys) (14.75%), and c.728G > A, p.(Arg243Gln) (7.65%). The frequency of the c.158G > A, p.(Arg53His) variant was highest in patients with mild hyperphenylalaninemia, whereas the frequency of the c.1197A > T, p.(Val399 =) and c.331C > T, p.(Arg111Ter) variants was highest in patients with classic phenylketonuria. The most abundant genotypes observed in PAHD patients were c.[158G > A];[728G > A], c.[158G > A];[442-1G > A], and c.[158G > A];[721C > T]. Comparing allelic phenotype to genotypic phenotype values yielded fairly accurate predictions of phenotype, with an overall consistency rate was 85.71% for PAHD patients. Conclusions Our study identified a PAH variant spectrum in PAHD patients from Fujian Province, Southeastern China. Quantitative correlation analysis between genotype and phenotype severity is helpful for genetic counseling and management.

Does isolated nuchal translucency from 2.5 to 2.9 mm increase the risk of fetal chromosome disease? - Daishu Yin; Lin Chen; Li Wang; Yang Zeng; Feng Tang; Jing Wang (Molecular Genetics and Genomics, 2022)

Synthesis and biological evaluation of new thiazolyl-urea derivatives as potential dual C-RAF/FLT3 inhibitors - Zhi-Hua Zhang; Bi-Fan Zeng; Zhe-Xue Song; Ying-Yu Yang; Kai-yun Zhang; Xue Du; Lin-lin Zhang; Dong Cai (Medicinal Chemistry Research, 2022)

Circular RNA expression profile of systemic lupus erythematosus and its clinical significance as a potential novel biomarker - Wenyu Li; Runge Fan; Cheng Zhou; Yue Wei; Shunsheng Lin; Sijian Wen; Wen Zeng; Wei Hou; Cheng Zhao; Youkun Lin (Genes & Genomics, 2022)
Background Circular RNAs (circRNAs) are a class of endogenous noncoding RNAs that are more abundant, specific, and highly organized than linear RNAs. Increasing evidence supports that circRNAs may serve as diagnostic biomarkers in many diseases, but their potential as biomarkers in systemic lupus erythematosus (SLE) remains unclear. Objective We investigated the critical circRNAs involved in SLE progression and explored their potential application as biomarkers in SLE. Method RNA sequencing was conducted on peripheral blood mononuclear cells (PBMCs) from 4 SLE patients and 4 healthy volunteers. CircRNA profile data were analyzed to identify differentially expressed circRNAs and visualized via R software. After screening, qPCR analysis of target circRNA expression was performed using PBMCs from 31 SLE patients and 35 healthy volunteers. Correlations between circRNA expression levels and the SLEDAI score were assessed via Spearman correlation analysis. Finally, the performance of circRNAs as biomarkers in SLE was examined by receiver operating characteristic curve analysis. Results The result identified six differentially expressed circRNAs between SLE patients and healthy controls: hsa_circ_0006689, hsa_circ_0070562, hsa_circ_0006117, hsa_circ_0007683, hsa_circ_0042519, and hsa_circ_0008647. The validation analysis showed differing relative expression levels of hsa_circ_0007683, hsa_circ_0042519, hsa_circ_0008647, and hsa_circ_0006689 between SLE patients and healthy volunteers (P < 0.05), and hsa_circ_0006689 expression in PBMCs correlated with the SLEDAI score (P < 0.05). Furthermore, addition of hsa_circ_0006689 expression increased the sensitivities of anti-dsDNA antibody and anti-Sm antibody levels for SLE diagnosis (from 29.03 to 61.30% and 32.26–71.00%, respectively). Conclusion Our results suggest hsa_circ_0006689 may be a useful circRNA biomarker for SLE diagnosis and prognosis.

PDGFD switches on stem cell endothelial commitment - Weisi Lu; Peipei Xu; Boxiong Deng; Jianing Zhang; Ying Zhan; Xianchai Lin; Xiangzhong Xu; Zhaoxia Xia; Xiaoxi Yang; Xiaoling Zeng; Lijuan Huang; Bingbing Xie; et al. (Angiogenesis, 2022)
The critical factors regulating stem cell endothelial commitment and renewal remain not well understood. Here, using loss- and gain-of-function assays together with bioinformatic analysis and multiple model systems, we show that PDGFD is an essential factor that switches on endothelial commitment of embryonic stem cells (ESCs). PDGFD genetic deletion or knockdown inhibits ESC differentiation into EC lineage and increases ESC self-renewal, and PDGFD overexpression activates ESC differentiation towards ECs. RNA sequencing reveals a critical requirement of PDGFD for the expression of vascular-differentiation related genes in ESCs. Importantly, PDGFD genetic deletion or knockdown increases ESC self-renewal and decreases blood vessel densities in both embryonic and neonatal mice and in teratomas. Mechanistically, we reveal that PDGFD fulfills this function via the MAPK/ERK pathway. Our findings provide new insight of PDGFD as a novel regulator of ESC fate determination, and suggest therapeutic implications of modulating PDGFD activity in stem cell therapy.

Local temperature increases reduce soil microbial residues and carbon stocks - Xiao‐Min Zeng; Jiao Feng; Dai‐Lin Yu; Shu‐Hai Wen; Qianggong Zhang; Qiaoyun Huang; Manuel Delgado‐Baquerizo; Yu‐Rong Liu (Global Change Biology, 2022)
Warming is known to reduce soil carbon (C) stocks by promoting microbial respiration, which is associated with the decomposition of microbial residue carbon (MRC). However, the relative contribution of MRC to soil organic carbon (SOC) across temperature gradients is poorly understood. Here, we investigated the contribution of MRC to SOC along two independent elevation gradients of our model system (i.e., the Tibetan Plateau and Shennongjia Mountain in China). Our results showed that local temperature increases were negatively correlated with MRC and SOC. Further analyses revealed that rising temperature reduced SOC via decreasing MRC, which helps to explain future reductions in SOC under climate warming. Our findings demonstrate that climate warming has the potential to reduce C sequestration by increasing the decomposition of MRC, exacerbating the positive feedback between rising temperature and CO 2 efflux. Our study also considered the influence of multiple environmental factors such as soil pH and moisture, which were more important in controlling SOC than microbial traits such as microbial life‐style strategies and metabolic efficiency. Together, our work suggests an important mechanism underlying long‐term soil C sequestration, which has important implications for the microbial‐mediated C process in the face of global climate change.

Associations of metal profiles in blood with thyroiditis: a cross-sectional study - Yaosheng Luo; Huixian Zeng; Yanshi Ye; Genfeng Yu; Cheng Song; Siyang Liu; Xingying Chen; Yuqi Jiang; Hualin Duan; Yue Li; Shengqing He; Zhi Chen; et al. (Environmental Science and Pollution Research, 2022)
Autoimmune thyroiditis (AIT) is increasingly common, and serological markers include thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb). To determine if selected metals influence thyroiditis antibody positivity, this cross-sectional study investigated associations between metals and thyroiditis antibody status. Healthy individuals ( n = 1104) completed a questionnaire and underwent checkups of anthropometric parameters, thyroid function status, and levels of seven metals in blood (magnesium, iron, calcium, copper, zinc, manganese, and lead). Associated profiles of glyco- and lipid metabolism were also established. Logistic regression and restricted cubic spline (RCS) regression analysis were applied to adjudge associations between metals and TPOAb and TgAb status. It was found that, after adjusting for likely cofounding factors, participants with antibody positivity had significantly lower serum concentrations of magnesium and iron. When serum magnesium levels were analyzed in quartiles, the odds ratios of quartile 4 were 0.329–fold (95% confidence interval (CI): 0.167–0647) and 0.259-fold (95% CI 0.177–0.574) that of quartile 1 regarding TPOAb and TgAb positivity ( P = 0.004, 0.003). After adjustment, the RCS analysis detected nonlinear associations between iron and TPOAb and TgAb positivity ( P < 0.01, both). In stratified analyses, these associations regarding magnesium and iron remained for women of reproductive age, but not for postmenopausal women and men. We conclude that lower serum levels of magnesium and iron are associated with incremental positivity of thyroiditis antibodies and may be among the most important metals contributing to AIT in women of reproductive age.

New phenolic glycosides from Anemone chinensis Bunge and their antioxidant activity - Zeng-Guang Zhang; Yuan-Yuan Li; Bin Lin; Pei-Pei Guan; Yu Mu; Wen-Jun Qiao; Jing-Sheng Zhang; Xue-Shi Huang; Li Han (Natural Product Research, 2022)

Plasma Lipidomic Subclasses and Risk of Hypertension in Middle-Aged and Elderly Chinese - Zhenhua Niu; Qingqing Wu; Yaogan Luo; Di Wang; He Zheng; Yanpu Wu; Xiaowei Yang; Rong Zeng; Liang Sun; Xu Lin (Phenomics, 2022)

Clinical profiles and antimicrobial resistance patterns of invasive Salmonella infections in children in China - Wen Song; Qingwen Shan; Yue Qiu; Xianyao Lin; Chunhui Zhu; Zhiqiang Zhuo; Caihong Wang; Jianning Tong; Rui Li; Chaomin Wan; Yu Zhu; Minxia Chen; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2022)
Invasive Salmonella infections result in a significant burden of disease including morbidity, mortality, and financial cost in many countries. Besides typhoid fever, the clinical impact of non-typhoid Salmonella infections is increasingly recognized with the improvement of laboratory detection capacity and techniques. A retrospective multicenter study was conducted to analyze the clinical profiles and antimicrobial resistance patterns of invasive Salmonella infections in hospitalized children in China during 2016–2018. A total of 130 children with invasive Salmonella infections were included with the median age of 12 months (range: 1–144 months). Seventy-nine percent of cases occurred between May and October. Pneumonia was the most common comorbidity in 33 (25.4%) patients. Meningitis and septic arthritis caused by nontyphoidal Salmonella (NTS) infections occurred in 12 (9.2%) patients and 5 (3.8%) patients. Patients < 12 months (OR: 16.04) and with septic shock (OR: 23.4), vomit (OR: 13.33), convulsion (OR: 15.86), C-reactive protein (CRP) ≥ 40 g/L (OR: 5.56), and a higher level of procalcitonin (PCT) (OR: 1.05) on admission were statistically associated to an increased risk of developing meningitis. Compared to 114 patients with NTS infections , 16 patients with typhoid fever presented with higher levels of CRP and PCT ( P < 0.05). The rates of resistance to ampicillin, sulfamethoxazole/trimethoprim, ciprofloxacin, and ceftriaxone among Salmonella Typhi and NTS isolates were 50% vs 57.3%, 9.1% vs 24.8%, 0% vs 11.2%, and 0% vs 9.9%, respectively. NTS has been the major cause of invasive Salmonella infections in Chinese children and can result in severe diseases. Antimicrobial resistance among NTS was more common.

A novel antisense long non‐coding RNA participates in asexual and sexual reproduction by regulating the expression of GzmetE in Fusarium graminearum - Jie Wang; Wenping Zeng; Jiatao Xie; Yanping Fu; Daohong Jiang; Yang Lin; Weidong Chen; Jiasen Cheng (Environmental Microbiology, 2022)

Countrywide inter‐epidemic region migration pattern suggests the role of southwestern population in wheat stripe rust epidemics in China - Muhammad Awais; Sajid Ali; Meng Ju; Wei Liu; Gensheng Zhang; Zedong Zhang; Zejian Li; Xinyao Ma; Lin Wang; Zhimin Du; Xiaxia Tian; Qingdong Zeng; et al. (Environmental Microbiology, 2022)
Understanding countrywide pathogen population structure and inter‐epidemic region spread is crucial for deciphering crop potential losses. Wheat stripe rust caused by Puccinia striiformis f. sp. tritici is a destructive disease that affects worldwide wheat production, widespread in China, representing largest epidemic region globally. This study aimed to understand the population structure and migration route of P . striiformis f. sp. tritici across China based on sampling from 15 provinces representing six epidemic zones, viz., over‐summering, over‐wintering, eastern, Yun‐Gui, Xinjiang and Tibet epidemic regions. High genotypic diversity was recorded in over‐summering, Tibet and over‐wintering epidemic regions. Epidemic regions partly explain population subdivision with variable divergence ( F ST = 0.005–0.344). Xinjiang and Tibet epidemic regions were independent epidemic zones with least sharing of genotypes. Among other epidemic zones, i.e. over‐summering, over‐wintering, eastern and Yun‐Gui epidemic zones, re‐sampling MLGs, clustering‐based structure, DAPC analyses, relative migration and low divergence ( F ST from 0.006 to 0.073) revealed frequent geneflow. Yun‐Gui epidemic regions, with a potential for both over‐summering and over‐wintering, could play an important role in causing epidemics in main wheat‐cultivating areas of China. High diversity, recombination signatures and inter‐epidemic region migration patterns need to be considered in host‐resistant cultivar development in China and neighbouring countries, considering risk of long‐distance migration capacity of pathogen.

Icariin protects bone marrow mesenchymal stem cells in aplastic anemia by targeting MAPK pathway - Shu Deng; Yuqing Zeng; Jingjing Xiang; Shengyun Lin; Jianping Shen (Molecular Biology Reports, 2022)

Effects of regular addition and discontinuation of biosurfactant on hydrocarbon biodegradation and microorganisms in heavy oily sludge - Hanghai Zhou; Shichen Li; Lijia Jiang; Feng Zeng; Xiaoyun Lin; Chunlei Chen; Yanhong Li; Chunfang Zhang (Journal of Soils and Sediments, 2022)

Circ_0049472 regulates the damage of Aβ-induced SK-N-SH and CHP-212 cells by mediating the miR-107/KIF1B axis - Chaosheng Zeng; Huaijie Xing; Min Chen; Lin Chen; Pengxiang Li; Xiaowen Wu; Li Li (Experimental Brain Research, 2022)

Lignans and phenylpropanoids from the roots of Ficus hirta and their cytotoxic activities - Xian-Sheng Ye; Wen-Jing Tian; Xiang-Zhong Liu; Mi Zhou; De-Quan Zeng; Ting Lin; Guang-Hui Wang; Xin-Sheng Yao; Hai-Feng Chen (Natural Product Research, 2022)

Correction to: Inhibition of Dectin-1 Ameliorates Neuroinflammation by Regulating Microglia/Macrophage Phenotype After Intracerebral Hemorrhage in Mice - Xiongjie Fu; Hanhai Zeng; Jikuang Zhao; Guoyang Zhou; Hang Zhou; Jianfeng Zhuang; Chaoran Xu; Jianru Li; Yucong Peng; Yang Cao; Yin Li; Huaijun Chen; et al. (Translational Stroke Research, 2022)

Correction to: Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated Encephalopathy by Promoting Ferroptosis Through Regulating miR-9-5p/ TFRC and GOT1 Axis - Xue-biao Wei; Wen-qiang Jiang; Ju-hao Zeng; Lin-qiang Huang; Hong-guang Ding; Yuan-wen Jing; Yong-li Han; Yi-chen Li; Sheng-long Chen (Molecular Neurobiology, 2022)

Activation of the TREK-1 Potassium Channel Improved Cognitive Deficits in a Mouse Model of Alzheimer’s Disease by Modulating Glutamate Metabolism - Fang Li; Shu-ning Zhou; Xin Zeng; Zhen Li; Rui Yang; Xue-xi Wang; Bin Meng; Wei-lin Pei; Li Lu (Molecular Neurobiology, 2022)

MiR-30c-1-3p targets matrix metalloproteinase 9 involved in the rupture of abdominal aortic aneurysms - Lin Yang; Hong-Gang Sui; Meng-Meng Wang; Jia-Yin Li; Xiao-Feng He; Jing-Yuan Li; Xiao-Zeng Wang (Journal of Molecular Medicine, 2022)
Abdominal aortic aneurysm (AAA) can be fatal if ruptured, but there is no predictive biomarker. Our aim was to evaluate the prognostic potential of microRNAs (miRNAs/miRs) in an AAA mouse model and patients with unruptured AAA (URAAA) and ruptured AAA (RAAA). Among the 64 miRNAs differentially expressed in mice with AAA compared to control, miR-30c-1-3p, miR-432-3p, miR-3154, and miR-379-5p had high homology with human miRNAs. MiR-30c-1-3p plasma levels were significantly lower in patients with RAAA than in those with URAAA or control and tended to negatively correlate with the maximum aortic diameter ( r = −0.3153, P = 0.06109). MiR-30c-1-3p targeted matrix metalloproteinase ( MMP)-9 mRNA through the coding region and downregulated its expression in vitro. MMP-9 plasma concentrations were significantly higher in the RAAA group than in the URAAA group ( P < 0.001) and were negatively associated with miR-30c-1-3p levels ( r = −0.3671, P = 0.01981) and positively–with the maximal aortic diameter ( r = 0.6251, P < 0.0001). The optimal cutoff values for MMP-9 expression and the maximal aortic diameter were 461.08 ng/ml and 55.95 mm, with areas under the curve of 0.816 and 0.844, respectively. Our results indicate that plasma levels of miR-30c-1-3p and MMP-9 may be candidate biomarkers of AAA progression. Key messages Downregulation of miR-30c-1-3p expression and upregulation of its potential target MMP-9 are predictors of the devastation of AAA. Downregulation of miR-30c-1-3p expression and its downstream impact on MMP-9 have a potential on predicting the development and rupture of AAA.

Ginsenoside Rb3 attenuates skin flap ischemia-reperfusion damage by inhibiting STING-IRF3 signaling - Yuanbin Li; Haifen Liu; Zhaohui Zeng; Hui Lin; Xin Chen; Xianglian Yuan; Jizhe Qiu; Fengchun Fu; Zhuang Chen; Jianjun Kuang (Journal of Molecular Histology, 2022)

A Novel Preparation Method for Effervescent Tablets of Xianganfang Containing Fresh Juice using a Semi-Solid Extrusion 3D Printer with Three Cartridge Holders - Xiangru Dong; Wenfang Zhang; Xiaoting Wang; Sijia Liu; Jiawei Liang; Chunqiao Liufu; Shaofeng Zeng; Jiali Pang; Siting Li; Lingjuan Xiong; Guoyan Zhou; Weixing Zhu; et al. (AAPS PharmSciTech, 2022)

Effects of nitrogen addition on the concentration and composition of soil-based dissolved organic matter in subtropical Pinus taiwanensis forests - Xiaochun Yuan; Juyan Cui; Kaimiao Lin; Cheng-Chung Liu; Jiacong Zhou; Qiufang Zhang; Quanxin Zeng; Lianzuan Wu; Yue Wu; Kongcan Mei; Huiying Lin; Huan Xie; et al. (Journal of Soils and Sediments, 2022)

Biochemical and structural characterization of the cyanophage‐encoded phosphate‐binding protein: implications for enhanced phosphate uptake of infected cyanobacteria - Fangxin Zhao; Xingqin Lin; Kun Cai; YongLiang Jiang; Tianchi Ni; Yue Chen; Jianrong Feng; Shangyu Dang; Cong‐Zhao Zhou; Qinglu Zeng (Environmental Microbiology, 2022)
Summary To acquire phosphorus, cyanobacteria use the typical bacterial ABC‐type phosphate transporter, which is composed of a periplasmic high‐affinity phosphate‐binding protein PstS and a channel formed by two transmembrane proteins PstC and PstA. A putative pstS gene was identified in the genomes of cyanophages that infect the unicellular marine cyanobacteria Prochlorococcus and Synechococcus . However, it has not been determined whether the cyanophage PstS protein is functional during infection to enhance the phosphate uptake rate of host cells. Here we showed that the cyanophage P‐SSM2 PstS protein was abundant in the infected Prochlorococcus NATL2A cells and the host phosphate uptake rate was enhanced after infection. This is consistent with our biochemical and structural analyses showing that the phage PstS protein is indeed a high‐affinity phosphate‐binding protein. We further modelled the complex structure of phage PstS with host PstCA and revealed three putative interfaces that may facilitate the formation of a chimeric ABC transporter. Our results provide insights into the molecular mechanism by which cyanophages enhance the phosphate uptake rate of cyanobacteria. Phosphate acquisition by infected bacteria can increase the phosphorus contents of released cellular debris and virus particles, which together constitute a significant proportion of the marine dissolved organic phosphorus pool.

Sesquiterpene lactones from Carpesium abrotanoides L. and their activity in inducing protective autophagy - Bao-Jia Yang; Juan Wang; Zheng-Quan Zeng; Xu Yang; Ai-Ying Huang; Xiao-Jiang Hao; Xiao Ding; Shun-Lin Li (Natural Product Research, 2022)

Industrial scale-up of tissue-cultured Dracaena cambodiana Pierre ex Gagnep - Feng Zheng; Yuping Xiong; Kunlin Wu; Jaime A. Teixeira da Silva; Songjun Zeng; Xuemao Lin; Guohua Ma (Trees, 2022)

Dynamics of soil organic carbon in different-sized aggregates under splash erosion - Junqiu Lin; Nufang Fang; Yan Zhang; Yi Zeng; Daming Yang; Wei Dai; Ling Wang; Zhihua Shi (Journal of Soils and Sediments, 2022)

Priming of rice defense against a sap-sucking insect pest brown planthopper by silicon - Yibin Lin; Xianhui Lin; Chaohui Ding; Ming Xia; Rongrong Xue; Zhongxiang Sun; Daoqian Chen; Keyan Zhu-Salzman; Rensen Zeng; Yuanyuan Song (Journal of Pest Science, 2022)

Detection of bloom-forming dinoflagellates Karenia mikimotoi and Prorocentrum donghaiense using qPCR assays - Xiao-Kun Hu; Zhuo-Ru Lin; Qing-Chun Zhang; Fan-Zhou Kong; Jing-Yi Cen; Yu-Lan Zeng; Ren-Cheng Yu (Journal of Applied Phycology, 2022)

Angiopoietin-Like Protein 4 Is Involved in Manganese Superoxide Dismutase-Mediated Suppression of Breast Cancer Cell Growth - P. Li; X. Zeng; Y. Liu; M. Lin (Bulletin of Experimental Biology and Medicine, 2022)

Ultrasound-induced biophysical effects in controlled drug delivery - Lulu Zhang; Zhuohua Lin; Lan Zeng; Fan Zhang; Lihong Sun; Suhui Sun; Ping Wang; Menghong Xu; Jinxia Zhang; Xiaolong Liang; Huiyu Ge (Science China Life Sciences, 2022)

Post-failure evolution analysis of an irrigation-induced loess landslide using multiple remote sensing approaches integrated with time-lapse ERT imaging: lessons from Heifangtai, China - Shiqiang Bian; Guan Chen; Runqiang Zeng; Xingmin Meng; Jiacheng Jin; Linxin Lin; Yi Zhang; Wei Shi (Landslides, 2022)

Berberisides A-D: three novel prenylated benzoic acid derivatives and a clerodane glycoside from Berberis tsarica aherndt. - Zhao-Yue Dong; Qing-Hong Zeng; Lin Wei; Xin Guo; Yan Sun; Fan-Cheng Meng; Guo-Wei Wang; Xiao-Zhong Lan; Zhi-Hua Liao; Min Chen (Natural Product Research, 2022)

Designing and the Pilot Trial of Bivalve Molluscan Fishing Quotas on Maoming Coastal Waters of China, Northern South China Sea - Shaoliang Lyu; Siman Deng; Kun Lin; Jiawei Zeng; Xuefeng Wang (Frontiers in Marine Science, 2022)
In the context of the declining fishery resources, some active management measures have been taken to strive for the sustainable development of fisheries. However, these input-oriented control management measures have not realized the expectation in alleviating the depressing depletion of fishery resources. The fishing quota (FQ) system, an output-oriented control management method, has been proved to be effective in curbing overfishing and conserving fishery resources. However, it has not been formally implemented in China until now. Thus, it is urgent to start the pilot trial on the implementation of the FQ system in China. We firstly formulated a framework for the FQ system on bivalve fisheries and then conducted an empirical analysis based on the field survey of bivalve mollusks in Maoming shallow waters, Guangdong, northern South China Sea. The species composition, dominant species, and density distribution of bivalves were analyzed. The swept-area method was used to assess the total allowable catch (TAC) of bivalves. Each step of the FQ system was discussed in depth. Results showed that a total of 45 bivalve species were identified. Meretrix planisulcata and Ruditapes philippinarum were the two dominant species. The spatial distribution of density varied largely. The estimated TAC value is 4.28 × 10 5 kg which can be allocated to fishermen under the regulations of the FQ system. Finally, the framework for the FQ system was improved in every step of the future procedure, including target species selection, TAC determination, quota allocation, catch report, and fishing supervision. The general framework of the FQ system in this study can also be referenced to other economically important fish or other marine organisms.

A biosurfactant-producing yeast Rhodotorula sp.CC01 utilizing landfill leachate as nitrogen source and its broad degradation spectra of petroleum hydrocarbons - Xiaoyun Lin; Hanghai Zhou; Feng Zeng; Lijia Jiang; Edidiong Okokon Atakpa; Gen Chen; Chunfang Zhang; Qinglin Xie (World Journal of Microbiology and Biotechnology, 2022)

Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China - Pengfei Cui; Xianying Zeng; Xuyong Li; Yanbing Li; Jianzhong Shi; Conghui Zhao; Zhiyuan Qu; Yanwen Wang; Jing Guo; Wenli Gu; Qi Ma; Yuancheng Zhang; et al. (Science China Life Sciences, 2022)
The H5N8 avian influenza viruses have been widely circulating in wild birds and are responsible for the loss of over 33 million domestic poultry in Europe, Russia, Middle East, and Asia since January 2020. To monitor the invasion and spread of the H5N8 virus in China, we performed active surveillance by analyzing 317 wild bird samples and swab samples collected from 41,172 poultry all over the country. We isolated 22 H5N8 viruses from wild birds and 14 H5N8 viruses from waterfowls. Genetic analysis indicated that the 36 viruses formed two different genotypes: one genotype viruses were widely detected from different wild birds and domestic waterfowls; the other genotype was isolated from a whopper swan. We further revealed the origin and spatiotemporal spread of these two distinct H5N8 virus genotypes in 2020 and 2021. Animal studies indicated that the H5N8 isolates are highly pathogenic to chickens, mildly pathogenic in ducks, but have distinct pathotypes in mice. Moreover, we found that vaccinated poultry in China could be completely protected against H5N8 virus challenge. Given that the H5N8 viruses are likely to continue to spread in wild birds, vaccination of poultry is highly recommended in high-risk countries to prevent H5N8 avian influenza.

Preparation and In Vitro and In Vivo Evaluation of a Testosterone Film Forming Gel for the Treatment of Hypoactive Sexual Desire Disorder in Women - Jia Zeng; Tan-Fang Xie; Ting Huang; Fang Li; Zhi-Ping Wang; Ling-Lin Feng (AAPS PharmSciTech, 2022)

Optimal reduction of anthropogenic emissions for air pollution control and the retrieval of emission source from observed pollutants III: Emission source inversion using a double correction iterative method - Qingcun Zeng; Lin Wu (Science China Earth Sciences, 2022)

Transcriptomic analyses provide insight into adventitious root formation of Euryodendron excelsum H. T. Chang during ex vitro rooting - Yuping Xiong; Shuangyan Chen; Zhenpeng Wei; Xiaohong Chen; Beiyi Guo; Ting Zhang; Yuying Yin; Xincheng Yu; Jinhui Pang; Meiyun Niu; Xinhua Zhang; Yuan Li; et al. (Plant Cell, Tissue and Organ Culture (PCTOC), 2022)

Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated Encephalopathy by Promoting Ferroptosis Through Regulating miR-9-5p/TFRC and GOT1 Axis - Xue-biao Wei; Wen-qiang Jiang; Ju-hao Zeng; Lin-qiang Huang; Hong-guang Ding; Yuan-wen Jing; Yong-li Han; Yi-chen Li; Sheng-long Chen (Molecular Neurobiology, 2022)
Sepsis can cause sepsis-associated encephalopathy (SAE), but whether SAE was induced or exacerbated by ferroptosis remains unknown. In this study, the rat sepsis model was constructed using the cecal ligation and puncture method. The blood–brain barrier (BBB) permeability was measured by Evans blue dye (EBD) in vivo. The levels of ROS, Fe ion, MDA, GSH, and GPX4 were assessed by enzyme-linked immunosorbent assay (ELISA). The exosomes isolated from serum were cultured with bEnd.3 cells for the in vitro analysis. Moreover, bEnd.3 cells cultured with 100 μM FeCl3 (iron-rich) were to simulate ferroptosis stress. The cell viability was evaluated by Cell Counting Kit-8 (CCK-8) assay. A dual-luciferase reporter gene assay was performed to confirm the relationship between miR-9-5p with NEAT1, TFRC , and GOT1 . In vivo, it is found that BBB permeability was damaged in model rats. Level of ROS, Fe ion, and MDA was increased, and level of GSH and GPX4 was decreased, which means ferroptosis was induced by sepsis. Exosome-packaged NEAT1 in serum was significantly upregulated in model rats. In vitro, it is found that NEAT1 functions as a ceRNA for miR-9-5p to facilitate TFRC and GOT1 expression. Overexpression of NEAT1 enhanced ferroptosis stress in bEnd.3 cells. Increased miR-9-5p alleviated sepsis-induced ferroptosis by suppressing the expression of TFRC and GOT1 both in vivo and in vitro. In conclusion, these findings suggest that sepsis induced high expression of serous exosome-derived NEAT1, and it might exacerbate SAE by promoting ferroptosis through regulating miR-9-5p/ TFRC and GOT1 axis.

Identification of low grain cadmium accumulation genotypes and its physiological mechanism in maize (Zea mays L.) - Kaina Lin; Darron V. Williams; Meng Zeng; Imrul Mosaddek Ahmed; Huaxin Dai; Fangbin Cao; Feibo Wu (Environmental Science and Pollution Research, 2022)

A Challenge to Conventional Fish Meal: Effects of Soy Protein Peptides on Growth, Histomorphology, Lipid Metabolism and Intestinal Health for Juvenile Pompano Trachinotus ovatus - Huaxing Lin; Beiping Tan; Gyan Watson Ray; Min Zeng; Mei Li; Shuyan Chi; Qihui Yang (Frontiers in Marine Science, 2022)
This experiment was conducted to assess the possibility of replacing fish meal (FM) with soy protein peptide (SPP) at different levels—0% (FM), 14.29% (S5), 28.57% (S10), 57.14% (S20), 71.42%(S25)—and its effects on growth, histology, gene expression related to liver lipid metabolism and intestinal immunity in juvenile pompano Trachinotus ovatus (initial mean weight = 39.88 ± 0.15 g). 600 healthy and uniformed-size fish were distributed to five groups of three replicates, each with 40 fish in each floating cage and fed twice daily for 8 weeks. Results showed that no significant difference in the growth was observed with SPP replacing FM ( P > 0.05). Serum glutathione peroxidase activity in the S10 group was significantly higher than that in the FM group, and serum malondialdehyde content significantly decreased ( P < 0.05). SPP significantly improved intestinal immunity by increasing alkaline phosphatase and lysozyme activities and up-regulating interleukin 10 and complement 4 mRNA levels while simultaneously decreasing triglyceride and total cholesterol content and down-regulating interleukin 1β mRNA expression. Villus length and muscle thickness in the S10 group were significantly higher than those in the FM group ( P < 0.05). SPP significantly improved liver fat metabolism by increasing carnitine palmitoyl transferase I mRNA levels, and down-regulating fatty acid synthesis mRNA expression ( P < 0.05). In summary, SPP substitution for FM promoted intestinal health, liver lipid metabolism and reduced liver fat accumulation for juvenile pompano T. ovatus , with no significant effect on growth performance. Based on the second-order polynomial analysis model of LYZ activity, the optimal replacement SPP level for juvenile pompano T. ovatus was 11.82%.

Oxygen Metabolism-induced Stress Response Underlies Heart–brain Interaction Governing Human Consciousness-breaking and Attention - Xiao-Juan Xue; Rui Su; Ze-Feng Li; Xiao-Ou Bu; Peng Dang; Si-Fang Yu; Zhi-Xin Wang; Dong-Mei Chen; Tong-Ao Zeng; Ming Liu; Hai-Lin Ma; De-Long Zhang (Neuroscience Bulletin, 2022)

Identification and bioinformatics analysis of differentially expressed milk exosomal microRNAs in milk exosomes of heat-stressed Holstein cows - Yue Wang; Jian Fang; Han-Fang Zeng; Ji-Feng Zhong; Hui-Xia Li; Kun-Lin Chen (Functional & Integrative Genomics, 2022)

Solidification of chromium-containing sludge with attapulgite combined alkali slag - Huirong Lin; Linghao Zeng; Pengpeng Zhang; Binquan Jiao; YanChyuan Shiau; Dongwei Li (Environmental Science and Pollution Research, 2022)

Detection of functional and structural brain alterations in female schizophrenia using elastic net logistic regression - Ying Wu; Ping Ren; Rong Chen; Hong Xu; Jianxing Xu; Lin Zeng; Donghui Wu; Wentao Jiang; NianSheng Tang; Xia Liu (Brain Imaging and Behavior, 2022)
Neuroimaging technique is a powerful tool to characterize the abnormality of brain networks in schizophrenia. However, the neurophysiological substrate of schizophrenia is still unclear. Here we investigated the patterns of brain functional and structural changes in female patients with schizophrenia using elastic net logistic regression analysis of resting-state functional magnetic resonance imaging data. Data from 52 participants (25 female schizophrenia patients and 27 healthy controls) were obtained. Using an elastic net penalty, the brain regions most relevant to schizophrenia pathology were defined in the models using the amplitude of low-frequency fluctuations (ALFF) and gray matter, respectively. The receiver operating characteristic analysis showed reliable classification accuracy with 85.7% in ALFF analysis, and 77.1% in gray matter analysis. Notably, our results showed eight common regions between the ALFF and gray matter analyses, including the Frontal-Inf-Orb-R, Rolandic-Oper-R, Olfactory-R, Angular-L, Precuneus-L, Precuenus-R, Heschl-L, and Temporal-Pole-Mid-R. In addition, the severity of symptoms was found positively associated with the ALFF within the Rolandic-Oper-R and Frontal-Inf-Orb-R. Our findings indicated that elastic net logistic regression could be a useful tool to identify the characteristics of schizophrenia -related brain deterioration, which provides novel insights into schizophrenia diagnosis and prediction.

Biomimetic synthesis of 6-substituted dihydrobenzophenanthridine alkaloids based on visible-light promoted radical addition reaction - Pi Cheng; Wei Wang; Xinhao Wang; Lin Wang; Wei Liu; Jianguo Zeng (Natural Product Research, 2022)

Distinct durability of IgM/IgG antibody responses in COVID-19 patients with differing severity - Junyan Han; Ning Zhang; Danying Chen; Yuhuan Gong; Guoli Li; Yaxian Kong; Lin Pu; Chen Chen; Jingyuan Liu; Qi Wang; Ju Zhang; Xuesen Zhao; et al. (Science China Life Sciences, 2022)

Multi-loop pipe freezing optimization of deep shaft considering seepage effect - Haibing Cai; Fangxing Yao; Rongbao Hong; Jian Lin; Kun Zeng (Arabian Journal of Geosciences, 2022)

Streptomyces blattellae, a novel actinomycete isolated from the in vivo of a Blattella germanica - Gui-Min Liu; Lin-Lin Yuan; Li-Li Zhang; Hong Zeng (Antonie van Leeuwenhoek, 2022)

Mycorrhizal associations of tree species influence soil nitrogen dynamics via effects on soil acid–base chemistry - Guigang Lin; Matthew E. Craig; Insu Jo; Xugao Wang; De‐Hui Zeng; Richard P. Phillips (Global Ecology and Biogeography, 2022)
Aim Plants and their associated microbes influence nutrient cycling in terrestrial ecosystems, yet we have a limited understanding of how soil acidity mediates the process. Here, we investigate whether reported differences in nitrogen (N) cycling between forests dominated by arbuscular mycorrhizal (AM) trees and ectomycorrhizal (ECM) trees are related to changes in soil acid–base chemistry induced by mycorrhizal associations. Location Global. Time period 1969–2018. Major taxa studied Trees. Methods We measured and synthesized variables of leaf litter quality, soil acid–base chemistry and N cycling from: (1) a landscape‐scale study of 230 subplots varying widely in AM tree dominance in a 25 ha forest plot; (2) a regional‐scale study of 40 AM‐ and 56 ECM‐dominated plots in 10 temperate forests across the eastern USA; (3) a continental‐scale study of > 3,000 forest plots from 10 ecoregions across the contiguous USA; and (4) a global meta‐analysis of 105 study sites with co‐occurring AM and ECM forest stands. Results Across all spatial scales, ECM‐dominated forests were associated with greater soil acidity. In particular, ECM‐dominated soils exhibited lower soil pH and base cations, although the magnitude of mycorrhizal‐associated differences in soil acid–base chemistry depended on the biomes, with differences being more pronounced in temperate than in sub/tropical forests. Higher lignin and lower base cations in ECM tree leaf litter were related to greater soil acidity in ECM‐dominated forests. Moreover, the lower inorganic N concentrations and slower N transformation rates in ECM‐dominated forests were associated with their greater soil acidity. Main conclusions Our results indicate that the scale‐invariant feedbacks between plant nutrient‐use strategies and soil properties have the potential to impact forest community assembly and ecosystem processes, particularly in the context of global change.

Inhibition of Dectin-1 Ameliorates Neuroinflammation by Regulating Microglia/Macrophage Phenotype After Intracerebral Hemorrhage in Mice - Xiongjie Fu; Hanhai Zeng; Jikuang Zhao; Guoyang Zhou; Hang Zhou; Jianfeng Zhuang; Chaoran Xu; Jianru Li; Yucong Peng; Yang Cao; Yin Li; Huaijun Chen; et al. (Translational Stroke Research, 2021)

Identification and characterization of L-type lectin receptor-like kinases involved in Glycine max–Phytophthora sojae interaction - Mengzhu Zeng; Bowen Wan; Lei Wang; Zhiyuan Chen; Yachun Lin; Wenwu Ye; Yan Wang; Yuanchao Wang (Planta, 2021)

Silencing of H19 alleviates oxygen–glucose deprivation/reoxygenation-triggered injury through the regulation of the miR-1306-5p/BCL2L13 axis - Yuxing Huang; Lisha Deng; Lin Zeng; Shanlin Bao; Kun Ye; Chengxun Li; Xiaolin Hou; Yuan Yao; Dingjun Li; Zhen Xiong (Metabolic Brain Disease, 2021)

M1 macrophages-derived exosomes miR-34c-5p regulates interstitial cells of Cajal through targeting SCF - Su Xu; Jinhai Zhai; Ke Xu; Xingguo Zuo; Chenghua Wu; Tao Lin; Li Zeng (Journal of Biosciences, 2021)

Efficiency and mechanism of a vermicompost additive in enhancing composting of swine manure - Xiaoxia Hao; Xinyuan Ma; Bo Zeng; Li Zhu; Linyuan Shen; Mingxian Yang; Hongwen Hu; Dongmei Jiang; Lin Bai (Environmental Science and Pollution Research, 2021)

Distribution characteristics of per- and polyfluoroalkyl substances (PFASs) in human urines of acrylic fiber plant and chemical plant - Lin Peng; Wang Xu; Qinghuai Zeng; Yao Cheng; Yingjie Zhang; Ying Guo; Da Chen; Chao Jiang; Fei Wang (Environmental Science and Pollution Research, 2021)

Effect of lgals3a on embryo development of zebrafish - Kan Chen; Yuqi Fan; Jun Gu; Zhihua Han; Yue Wang; Lin Gao; Huasu Zeng; Chengyu Mao; Changqian Wang (Transgenic Research, 2021)

Associations of bisphenol exposure with the risk of gestational diabetes mellitus: a nested case–control study in Guangxi, China - Peng Tang; Jun Liang; Qian Liao; Huishen Huang; Xiaojing Guo; Mengrui Lin; Bihu Liu; Bincai Wei; Xiaoyun Zeng; Shun Liu; Dongping Huang; Xiaoqiang Qiu (Environmental Science and Pollution Research, 2021)

Effects of Food Concentration and Photoperiod on Egg Production, Female Life Expectancy and Population Dynamics of the Paracalanid Copepod, Bestiolina amoyensis - Lin Wang; Shuhong Wang; Chaoshu Zeng; Yuyue Wang; Chunxiao Zeng (Frontiers in Marine Science, 2021)
The paracalanid copepod, Bestiolina amoyensis , is a widely distributed species occurring in subtropical inshore waters across the Pacific Ocean. Its small size, herbivorous feeding habit, and high adaptability make the species one of the most promising candidates as potential live feed for hatchery larval rearing. This study investigated effects of different feeding density of microalgae Isochrysis spp. (1 × 10 5 , 2 × 10 5 , 3 × 10 5 , 4 × 10 5 , and 5 × 10 5 cells ml –1 ) and photoperiod (8L:16D, 12L:12D, and 16L:8D) on productivity-related parameters, including egg production, female life expectancy and population dynamics of B. amoyensis . Results showed that total egg output over female lifespan, final population size and intrinsic rate of population of 12L:12D photoperiod treatments were always the highest among three photoperiod conditions, especially at the food concentration of 4 × 10 5 cells ml –1 , indicating B. amoyensis had high reproductive performance and the population was in a more stable status. The number of nauplii from 4 × 10 5 cells ml –1 algal concentration treatment accounted for 75% of the population, and the ratio of females to males approaching 1:1 when photoperiod was 12L:12D; female life expectancy was 10.5 ± 0.6 days. In conclusion, our results showed that Isochrysis spp. is a suitable feed for B. amoyensis with an optimal concentration at 4 × 10 5 cells mL –1 ; the optimal photoperiod for B. amoyensis rearing is 12L:12D. The relatively long reproductive lifespan and high intrinsic population increase rate make B. amoyensis a good candidate to develop culture techniques for hatchery larval rearing.

In situ geochemistry and Fe–O isotopic composition of iron oxides from the Pha Lek Fe deposit, northwest Truong Son orogenic belt, Laos: implications for ore-forming processes - Lin Hou; Linnan Guo; Siwei Xu; Qiming Zhang; Xiangting Zeng (Mineralium Deposita, 2021)

Sediment Coarsening in Tidal Flats and Stable Coastline of the Abandoned Southern Yellow River Sub-Delta in Response to Fluvial Sediment Flux Decrease During the Past Decades - Lin Zeng; Chao Zhan; Qing Wang; Xianbin Liu; Longsheng Wang; Xueyan Li; Xin Wang; Xiang Yu; Jinzhi Zhang; Buli Cui (Frontiers in Marine Science, 2021)
Due to remarkable reduction of sediment supply, the vulnerability of Yellow River deltaic system increased and ecological impacts occurred to some extent. To have a comprehensive and quantitative understanding of the morphological evolution of deltas, surficial sediments of tidal flat along the abandoned southern Yellow River sub-delta and two adjacent coastal units were systematically collected and evaluated by grain-size analysis in the study. The results reveal that surficial sediments of the abandoned southern Yellow River sub-delta have been coarsening significantly since the 1980s, as characterized by a decrease in both the mud content and the clay/mud ratio. In particular, the transition from cohesive to non-cohesive sediment was completed between 2007 and 2013. With a sharp decrease in sediment flux from the Yellow River estuary, the flood currents from the submarine coastal slope carry few fine particles into the tidal zone, whereas the ebb currents with reverse direction remove some fine particles from the tidal flat. This is a major cause of sediment coarsening in the tidal flat. As sediment coarsening, the coastline of the abandoned southern Yellow River sub-delta has remained stable. The significant change in the grain size of the tidal flat surficial sediments may have a profound impact on the future coastal geomorphic evolution.

A new abietane diterpene and anti-complementary constituents from Juniperus tibetica - Dong-Lin Zeng; Chang-Yue Wang; Hui-Qin Gao; Dao-Feng Chen; Yan Lu (Natural Product Research, 2021)

Complement C3 Aggravates Post-epileptic Neuronal Injury Via Activation of TRPV1 - Guang-Tong Jiang; Lin Shao; Shuo Kong; Meng-Liu Zeng; Jing-Jing Cheng; Tao-Xiang Chen; Song Han; Jun Yin; Wan-Hong Liu; Xiao-Hua He; Yu-Min Liu; Lanzi Gongga; et al. (Neuroscience Bulletin, 2021)

An efficient genetic manipulation protocol for dark septate endophyte Falciphora oryzae - Zhen-Zhu Su; Meng-Di Dai; Jia-Nan Zhu; Yu-Lan Zeng; Xuan-Jun Lu; Xiao-Hong Liu; Fu-Cheng Lin (Biotechnology Letters, 2021)

Glucose-Responsive Polyelectrolyte Complexes Based on Dendritic Mesoporous Silica for Oral Insulin Delivery - Tingting Qin; Libiao Yan; Xin Wang; Siqi Lin; Qingbing Zeng (AAPS PharmSciTech, 2021)

Microorganism and Physiochemical Characteristic of High-salt (Suan Yu), a Traditional Chinese Fermented Fish - Chengxing Lin; Furong Zhang; Qin Yang; Ju Meng; Laping He; Li Deng; Chun Ye; Xuefeng Zeng (Journal of Aquatic Food Product Technology, 2021)

The mechanism and application of bidirectional extracellular electron transport in the field of energy and environment - Qingqing Xie; Yue Lu; Lin Tang; Guangming Zeng; Zhaohui Yang; Changzheng Fan; Jingjing Wang; Siavash Atashgahi (Critical Reviews in Environmental Science and Technology, 2021)

Rice yellow stunt virus activates polyamine biosynthesis to promote viral propagation in insect vectors by disrupting ornithine decarboxylase antienzyme function - Xiao-Feng Zhang; Tianbao Zeng; Yunjie Xie; Yuemin Zheng; Huanqin Wang; Hanbin Lin; Zongwen Wang; Taiyun Wei (Science China Life Sciences, 2021)

Extensional tectonics and North China Craton destruction: Insights from the magnetic susceptibility anisotropy (AMS) of granite and metamorphic core complex - Wei Lin; Jipei Zeng; Lingtong Meng; Huabiao Qiu; Wei Wei; Zhiheng Ren; Yang Chu; Shuangjian Li; Chao Song; Qincheng Wang (Science China Earth Sciences, 2021)

Integration of small RNAs, degradome, and transcriptome sequencing provides insights into the differences between Shizhu ginseng and Yuan ginseng - Mengyuan Peng; Yanlin Chen; Wenjuan Wang; Zhihua He; Wangqiang Dai; Zhiyun Lin; Zemin Yang; Mengjuan Gong; Yongqin Yin; Bin Han; Yu Zeng; Yingfang Wang (Journal of Plant Biochemistry and Biotechnology, 2021)
Panax ginseng is one of the most popular herbs which have been used as an important traditional Chinese medicine since ancient times. Yuan ginseng and Shizhu ginseng,which belong to P. ginseng , are widely used as substitutes for wild ginseng in clinical practice. Clinical practice has proved that the clinical efficacy of Shizhu ginseng is better than Yuan ginseng. However, current research cannot completely explain this phenomenon. Considering that small RNA may be one of the pharmacodynamic substances of P. ginseng , it is challenging to investigate differential miRNAs between Shizhu ginseng and Yuan ginseng. In this study, the transcriptome, small RNAome and degradome of P. ginseng were studied by high-throughput sequencing. A total of 63,875 unigenes and 43,950,137 small RNA clean reads were obtained from the roots of P. ginseng . Among 3206 differentially expressed genes, 1190 genes were up-regulated in Yuan ginseng when compared with Shizhu ginseng. 24 known differential miRNAs and 7 novel differential miRNAs were obtained. The 304 targets of 24 differentially expressed miRNA (17 known and 7 novel) families are mainly related to energy metabolism, biotic stress and disease immunity in ginseng itself. Through the association analysis of mRNA and miRNA, our work gives a better understanding of the difference between Yuan ginseng and Shizhu ginseng. Considering the cross-kingdom regulation of plant miRNAs, our results may provide a foundation for understanding the miRNA-dependent clinical efficacy in P. ginseng .

Applying Artificial Intelligence (AI) Techniques to Implement a Practical Smart Cage Aquaculture Management System - Chung-Cheng Chang; Jung-Hua Wang; Jenq-Lang Wu; Yi-Zeng Hsieh; Tzong-Dar Wu; Shyi-Chy Cheng; Chin-Chun Chang; Jih-Gau Juang; Chyng-Hwa Liou; Te-Hua Hsu; Yii-Shing Huang; Cheng-Ting Huang; et al. (Journal of Medical and Biological Engineering, 2021)
Purpose This paper presents our team’s results to establish an AIoT smart cage culture management system. Methods According to the built system, the farmed field information is transmitted to the data platform of Ocean Cloud, and all collected data and analysis results can be applied to the cage culture field after the bigdata analysis. Results This management system successfully integrates AI and IoT technologies and is applied in cage culture. Using underwater biological analysis images and AI feeding as examples, this paper explains how the system integrates AI and IoT into a feasible framework that can constantly acquire information about the health status of fish, survival rate of fish, as well as the feed residuals. Conclusion The results of our research enable the aquaculture operators or owners to efficiently reduce the feed residual, monitor the growth of fish, and increase fish survival rate, thereby increasing the feed conversion rate.

Simulation study on the migration of F− in soil around Chagan Lake, China - Peng Xu; Jianmin Bian; Juanjuan Wu; Yihan Li; Jialin Li; Xia Zeng; Zuo Lin (Environmental Science and Pollution Research, 2021)

Estimation and Long-term Trend Analysis of Surface Solar Radiation in Antarctica: A Case Study of Zhongshan Station - Zhaoliang Zeng; Zemin Wang; Minghu Ding; Xiangdong Zheng; Xiaoyu Sun; Wei Zhu; Kongju Zhu; Jiachun An; Lin Zang; Jianping Guo; Baojun Zhang (Advances in Atmospheric Sciences, 2021)

A novel antisense long non‐coding RNA participates in asexual and sexual reproduction by regulating the expression of GzmetE in Fusarium graminearum - Jie Wang; Wenping Zeng; Jiatao Xie; Yanping Fu; Daohong Jiang; Yang Lin; Weidong Chen; Jiasen Cheng (Environmental Microbiology, 2021)
Summary Fusarium graminearum is an important worldwide pathogen that causes Fusarium head blight in wheat, barley, maize and other grains. LncRNAs play important roles in many biological processes, but little is known about their functions and mechanisms in filamentous fungi. Here, we report that a natural antisense RNA, GzmetE‐AS , is transcribed from the opposite strand of GzmetE . GzmetE encodes a homoserine O ‐acetyltransferase, which is important for sexual development and plant infection. The expression of GzmetE‐AS was increased significantly during the conidiation stage, while GzmetE was upregulated in the late stage of sexual reproduction. Overexpression of GzmetE‐AS inhibited the transcription of GzmetE . In contrast, the expression of GzmetE was significantly increased in GzmetE‐AS transcription termination strain GzmetE‐AS ‐T. Furthermore, GzmetE‐AS ‐T produced more perithecia and facilitated the ascospore discharge, resembling the phenotype of GzmetE overexpressing strains. However, overexpression of GzmetE‐AS in ∆dcl1/2 strain cannot inhibit the expression of GzmetE , and the GzmetE nat‐siRNA is also significantly reduced in ∆dcl1/2 mutant. Taken together, we have identified a novel antisense lncRNA GzmetE‐AS , which is involved in asexual and sexual reproduction by regulating its antisense gene GzmetE through RNAi pathway. Our findings reveal that the lncRNA plays critical roles in the development of F . graminearum .

Wogonin Accelerates Hematoma Clearance and Improves Neurological Outcome via the PPAR-γ Pathway After Intracerebral Hemorrhage - Jianfeng Zhuang; Yucong Peng; Chi Gu; Huihui Chen; Zheng Lin; Hang Zhou; Xiao Wu; Jianru Li; Xiaobo Yu; Yang Cao; Hanhai Zeng; Xiongjie Fu; et al. (Translational Stroke Research, 2021)

Prediction of Metabolic Disorders Using NMR-Based Metabolomics: The Shanghai Changfeng Study - Qi Wu; Qing-xia Huang; Hai-luan Zeng; Shuai Ma; Huan-dong Lin; Ming-feng Xia; Hui-ru Tang; Xin Gao (Phenomics, 2021)

Optimal estimates for dissolved and suspended particulate material fluxes in the Yangtze River, China - Tiantian Yang; Lin Zhang; Yao Yue; Bao Qian; Yuhong Zeng; Xiaofeng Zhang (Environmental Science and Pollution Research, 2021)

Ecological treatment technology for agricultural non-point source pollution in remote rural areas of China - Xuesong Yi; Dexin Lin; Jiahui Li; Jie Zeng; Dexin Wang; Fei Yang (Environmental Science and Pollution Research, 2021)

Evaluation of the RNA extraction methods in different Ginkgo biloba L. tissues - Xiao-lin Zhang; Xiao-li Huang; Jia Li; Mei Mei; Wan-qi Zeng; Xiu-jun Lu (Biologia, 2021)

Strong in vitro and in vivo cytotoxic effects of two platinum(II) complexes with cryptolepine derivatives - Li-Qin Qin; Zu-Zhuang Wei; Lin Yang; Qi-Pin Qin; Jia-Jing Zeng; Ming-Xiong Tan; Hong Liang (Medicinal Chemistry Research, 2021)

The mechanism and application of high-pressure water jet technology to prevent compound dynamic disaster - Zeng-qiang Yang; Chang Liu; Feng-shuo Li; Lin-ming Dou; Gang-wei Li; Da-wei Wang (Arabian Journal of Geosciences, 2021)

In-Situ Seawater Gamma Spectrometry with LaBr3 Detector at a Nuclear Power Plant Outlet - Daowei Dou; Zhi Zeng; Wen Yu; Ming Zeng; Wu Men; Feng Lin; Hao Ma; Jianping Cheng; Junli Li (Journal of Marine Science and Engineering, 2021)
In a nuclear emergency, the application of in situ spectrometers for monitoring environmental radioactivity is significantly important, as information on the type and activity of radionuclides released from the accident can be obtained quickly. However, in emergency environmental radiological monitoring, a balance between energy resolution and detecting efficiency must be considered in selecting an appropriate detector. In this study, in situ gamma spectrometry was conducted with the LaBr3 detector to determine the radioactivity of seawater at the discharging outlet of a coastal nuclear power plant in southeast China. The results show that the LaBr3 scintillator has excellent energy resolution and detection efficiency, making it a promising detector for emergency monitoring.

Diversity of Diaporthe species associated with melanose disease on citrus trees in Jiangxi Province, China - Zhe-Zheng Zeng; Chingchai Chaisiri; Xiang-Yu Liu; Yang Lin; Chao-Xi Luo (European Journal of Plant Pathology, 2021)

Genome sequencing and functional annotation of Bacillus sp. strain BS-Z15 isolated from cotton rhizosphere soil having antagonistic activity against Verticillium dahliae - Zhong-Yi Chen; Xieerwanimu Abuduaini; Nuramina Mamat; Qi-Lin Yang; Meng-Jun Wu; Xin-Rui Lin; Ru Wang; Rong-Rong Lin; Wei-Jun Zeng; Huan-Chen Ning; He-Ping Zhao; Jin-Yu Li; et al. (Archives of Microbiology, 2021)

Phytoactinopolyspora limicola sp. nov., an alkaliphilic actinomycete isolated from a soda alkali-saline soil - Wei Wei; Kaili Wang; Xinyu Hu; Sai Yang; Chunlin Zeng; Zhaozhi Hou; Shenkui Liu; Henglin Cui; Lin Zhu (Archives of Microbiology, 2021)

Human endothelial colony-forming cells provide trophic support for pluripotent stem cell-derived cardiomyocytes via distinctively high expression of neuregulin-1 - Xuechong Hong; Nicholas Oh; Kai Wang; Joseph Neumeyer; Chin Nien Lee; Ruei-Zeng Lin; Breanna Piekarski; Sitaram Emani; Arin K. Greene; Ingeborg Friehs; Pedro J. del Nido; Juan M. Melero-Martin (Angiogenesis, 2021)

Mortality burden caused by diurnal temperature range: a nationwide time-series study in 364 Chinese locations - Min Cai; Jianxiong Hu; Chunliang Zhou; Zhulin Hou; Yanjun Xu; Maigeng Zhou; Yize Xiao; Biao Huang; Xiaojun Xu; Lifeng Lin; Tao Liu; Jianpeng Xiao; et al. (Stochastic Environmental Research and Risk Assessment, 2021)

GTree: an Open-source Tool for Dense Reconstruction of Brain-wide Neuronal Population - Hang Zhou; Shiwei Li; Anan Li; Qing Huang; Feng Xiong; Ning Li; Jiacheng Han; Hongtao Kang; Yijun Chen; Yun Li; Huimin Lin; Yu-Hui Zhang; et al. (Neuroinformatics, 2021)

Microbiological profiles and antimicrobial resistance patterns of pediatric bloodstream pathogens in China, 2016–2018 - Yue Qiu; Junwen Yang; Yiping Chen; Jinhong Yang; Qingxiong Zhu; Chunhui Zhu; Shuangjie Li; Jing Liu; Chaomin Wan; Yu Zhu; Minxia Chen; Yi Xu; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Marinobacter shengliensis subsp. alexandrii Subsp. Nov., Isolated from Cultivable Phycosphere Microbiota of Highly Toxic Dinoflagellate Alexandrium catenella LZT09 and Description of Marinobacter shengliensis Subsp. shengliensis Subsp. Nov - Xi Yang; Rong Xiang; Nurhezreen Md Iqbal; Yu-Han Duan; Xiao-Ai Zhang; Lei Wang; Lin-Zeng Yu; Jia-Zhou Li; Ming-Fei Sun; Qiao Yang; Chun-Tian Zheng; Shen-Quan Liao (Current Microbiology, 2021)

Molecular characterization of miRNA genes and their expression in Dimocarpus longan Lour - Yuling Lin; Yan Chen; Youjing Zeng; Shuting Zhang; Zihao Zhang; YuKun Chen; Jiawei Gong; Zhongxiong Lai (Planta, 2021)

High expression of NEK2 promotes gastric cancer progression via activating AKT signaling - Hao Wan; Lin Xu; Huangbin Zhang; Feixiang Wu; Weiqiang Zeng; Taiyuan Li (Journal of Physiology and Biochemistry, 2021)

CAS-ESM2.0 Model Datasets for the CMIP6 Flux-Anomaly-Forced Model Intercomparison Project (FAFMIP) - Jiangbo Jin; He Zhang; Xiao Dong; Hailong Liu; Minghua Zhang; Xin Gao; Juanxiong He; Zhaoyang Chai; Qingcun Zeng; Guangqing Zhou; Zhaohui Lin; Yi Yu; et al. (Advances in Atmospheric Sciences, 2021)
The second version of the Chinese Academy of Sciences Earth System Model (CAS-ESM2.0) is participating in the Flux-Anomaly-Forced Model Intercomparison Project (FAFMIP) experiments in phase 6 of the Coupled Model Intercomparison Project (CMIP6). The purpose of FAFMIP is to understand and reduce the uncertainty of ocean climate changes in response to increased CO 2 forcing in atmosphere-ocean general circulation models (AOGCMs), including the simulations of ocean heat content (OHC) change, ocean circulation change, and sea level rise due to thermal expansion. FAFMIP experiments (including faf-heat, faf-stress, faf-water, faf-all, faf-passiveheat, faf-heat-NA50pct and faf-heat-NA0ct) have been conducted. All of the experiments were integrated over a 70-year period and the corresponding data have been uploaded to the Earth System Grid Federation data server for CMIP6 users to download. This paper describes the experimental design and model datasets and evaluates the preliminary results of CAS-ESM2.0 simulations of ocean climate changes in the FAFMIP experiments. The simulations of the changes in global ocean temperature, Atlantic Meridional Overturning Circulation (AMOC), OHC., and dynamic sea level (DSL), are all reasonably reproduced.

CAS-ESM2.0 Model Datasets for the CMIP6 Ocean Model Intercomparison Project Phase 1 (OMIP1) - Xiao Dong; Jiangbo Jin; Hailong Liu; He Zhang; Minghua Zhang; Pengfei Lin; Qingcun Zeng; Guangqing Zhou; Yongqiang Yu; Mirong Song; Zhaohui Lin; Ruxu Lian; et al. (Advances in Atmospheric Sciences, 2021)
As a member of the Chinese modeling groups, the coupled ocean-ice component of the Chinese Academy of Sciences’ Earth System Model, version 2.0 (CAS-ESM2.0), is taking part in the Ocean Model Intercomparison Project Phase 1 (OMIP1) experiment of phase 6 of the Coupled Model Intercomparison Project (CMIP6). The simulation was conducted, and monthly outputs have been published on the ESGF (Earth System Grid Federation) data server. In this paper, the experimental dataset is introduced, and the preliminary performances of the ocean model in simulating the global ocean temperature, salinity, sea surface temperature, sea surface salinity, sea surface height, sea ice, and Atlantic Meridional Overturning Circulation (AMOC) are evaluated. The results show that the model is at quasi-equilibrium during the integration of 372 years, and performances of the model are reasonable compared with observations. This dataset is ready to be downloaded and used by the community in related research, e.g., multi-ocean-sea-ice model performance evaluation and interannual variation in oceans driven by prescribed atmospheric forcing.

The involvement of α‐proteobacteria Phenylobacterium in maintaining the dominance of toxic Microcystis blooms in Lake Taihu, China - Jun Zuo; Lili Hu; Wei Shen; Jiaying Zeng; Lin Li; Lirong Song; Nanqin Gan (Environmental Microbiology, 2021)
Summary Lake Taihu in China has suffered serious harmful cyanobacterial blooms for decades. The algal blooms threaten the ecological sustainability, drinking water safety, and human health. Although the roles of abiotic factors (such as water temperature and nutrient loading) in promoting Microcystis blooms have been well studied, the importance of biotic factors (e.g. bacterial community) in promoting and meditating Microcystis blooms remains unclear. In this study, we investigated the ecological dynamics of bacterial community, the ratio of toxic Microcystis , as well as microcystin in Lake Taihu. High‐throughput 16S rRNA sequencing and principal component analysis (PCA) revealed that the bacteria community compositions (BCCs) clustered into three groups, the partitioning of which corresponded to that of groups according to the toxic profiles (the ratio of toxic Microcystis to total Microcystis , and the microcystin concentrations) of the samples. Further Spearman's correlation network showed that the α‐proteobacteria Phenylobacterium strongly positively correlated with the toxic profiles. Subsequent laboratory chemostats experiments demonstrated that three Phenylobacterium strains promoted the dominance of the toxic Microcystis aeruginosa PCC7806 when co‐culturing with the non‐toxic PCC7806 mcyB − mutant. Taken together, our data suggested that the α‐proteobacteria Phenylobacterium may play a vital role in the maintenance of toxic Microcystis dominance in Lake Taihu.

Moisture effects on the active prokaryotic communities in a saline soil unraveled by 18O-informed metagenomics - Yeliang Dai; Yanshuo Pan; Yue Sun; Jun Zeng; Guangming Liu; Wenhui Zhong; Xuanzhen Li; Yucheng Wu; Xiangui Lin (Journal of Soils and Sediments, 2021)

Structural and functional brain signatures of endurance runners - Long Cao; Yuanchao Zhang; Ruiwang Huang; Lunxiong Li; Fengguang Xia; Liye Zou; Qian Yu; Jingyuan Lin; Fabian Herold; Stephane Perrey; Patrick Mueller; Milos Dordevic; et al. (Brain Structure and Function, 2021)

Stocks and losses of soil organic carbon from Chinese vegetated coastal habitats - Chuancheng Fu; Yuan Li; Lin Zeng; Haibo Zhang; Chen Tu; Qian Zhou; Kuanxu Xiong; Jiaping Wu; Carlos M. Duarte; Peter Christie; Yongming Luo (Global Change Biology, 2021)
Global vegetated coastal habitats (VCHs) represent a large sink for organic carbon (OC) stored within their soils. The regional patterns and causes of spatial variation, however, remain uncertain. The sparsity and regional bias of studies on soil OC stocks from Chinese VCHs have limited the reliable estimation of their capacity as regional and global OC sinks. Here, we use field and published data from 262 sampled soil cores and 181 surface soils to report estimates of soil OC stocks, burial rates and losses of VCHs in China. We find that Chinese mangrove, salt marsh and seagrass habitats have relatively low OC stocks, storing 6.3 ± 0.6, 7.5 ± 0.6, and 1.6 ± 0.6 Tg C (±95% confidence interval) in the top meter of the soil profile with burial rates of 44 ± 17, 159 ± 57, and 6 ± 45 Gg C/year, respectively. The variability in the soil OC stocks is linked to biogeographic factors but is mostly impacted by sedimentary processes and anthropic activities. All habitats have experienced significant losses, resulting in estimated emissions of 94.2–395.4 Tg CO 2 e (carbon dioxide equivalent) over the past 70 years. Reversing this trend through conservation and restoration measures has, therefore, great potential in contributing to the mitigation of climate change while providing additional benefits. This assessment, on a national scale from highly sedimentary environments under intensive anthropogenic pressures, provides important insights into blue carbon sink mechanism and sequestration capacities, thus contributing to the synchronous progression of global blue carbon management.

The Application of Decellularized Adipose Tissue Promotes Wound Healing - Zenan Xia; Xiao Guo; Nanze Yu; Ang Zeng; Loubin Si; Fei Long; Wenchao Zhang; Xiaojun Wang; Lin Zhu; Zhifei Liu (Tissue Engineering and Regenerative Medicine, 2020)

Association of in-hospital intensive statins dosage and death in arteriosclerotic cardiovascular disease with percutaneous coronary intervention: insights of multicentre cohort from China - Peng-yuan Chen; Yuan-hui Liu; Chong-yang Duan; Hua-lin Fan; Li-huan Zeng; Wei Guo; Lei Jiang; Xue-biao Wei; Wen-fei He; Sha Tao; Zhi-qiang Guo; Ji-yan Chen; et al. (European Journal of Clinical Pharmacology, 2020)

The extract of aquatic macrophyte Carex cinerascens induced colony formation in bloom-forming cyanobacterium Microcystis aeruginosa - Lin Li; Xiao-ling Jing; Ling Wang; Zhi-gao Zeng; Wen-hong Chen; Jia-hao Zhai; Si-qin Qi (Environmental Science and Pollution Research, 2020)

EEG-based emotion recognition using 4D convolutional recurrent neural network - Fangyao Shen; Guojun Dai; Guang Lin; Jianhai Zhang; Wanzeng Kong; Hong Zeng (Cognitive Neurodynamics, 2020)

Two new species of Hortiboletus (Boletaceae, Boletales) from China - Hui-Jing Xie; Wen-Fei Lin; Shuai Jiang; Rou Xue; Lu-Ling Wu; Yu-Zhuo Zhang; Zhi-Qun Liang; Nian-Kai Zeng; Ming-Sheng Su (Mycological Progress, 2020)

Climate factors during key periods affect the comprehensive crop losses due to drought in Southern China - Qiang Zhang; Lanying Han; Jian Zeng; Xing Wang; Jingjing Lin (Climate Dynamics, 2020)

Porphyry Mo and epithermal Au–Ag–Pb–Zn mineralization in the Zhilingtou polymetallic deposit, South China - Yongbin Wang; Qingdong Zeng; Jianming Liu; Lin Wu; Kezhang Qin (Mineralium Deposita, 2020)

Verticillin A inhibits colon cancer cell migration and invasion by targeting c-Met - Qian-qian Liu; Xue-li Zeng; Yue-lin Guan; Jing-xin Lu; Kai Tu; Fei-yan Liu (Journal of Zhejiang University-SCIENCE B, 2020)

Identification of Prognostic Signatures of Alternative Splicing in Glioma - Yu Zeng; Peidong Zhang; Xizhao Wang; Ke Wang; Mingfeng Zhou; Hao Long; Jie Lin; Zhiyong Wu; Liang Gao; Ye Song (Journal of Molecular Neuroscience, 2020)

Preliminary results of mixed afforestation experiment of Betula alnoides Buch.-Ham. ex D. Don in Southern Fujian China - Bihua Chen; Bijiang Fang; Guobiao Chen; Yuqing Lin; Xinhua Dai; Yinzhen Liao; Xiaolong Hong; Qinggen Chen; Yongjian Lin; Juan Zhang; Jie Zeng; Junjie Guo; et al. (Vegetos, 2020)

Experimentally Induced Sepsis Causes Extensive Hypomyelination in the Prefrontal Cortex and Hippocampus in Neonatal Rats - Peixian Huang; Xuan Chen; Xiaoli Hu; Qiuping Zhou; Lanfen Lin; Shuqi Jiang; Hui Fu; Yajie Xiong; Hongke Zeng; Ming Fang; Chunbo Chen; Yiyu Deng (NeuroMolecular Medicine, 2020)

Correction to: Investigating the age composition of Indo-Pacific humpback dolphins in the Pearl River Estuary based on their pigmentation pattern - Lang Guo; Wenzhi Lin; Chen Zeng; Dingyu Luo; Yuping Wu (Marine Biology, 2020)

Gastrointestinal involvement of COVID-19 and potential faecal transmission of SARS-CoV-2 - Min Song; Zong-lin Li; Ye-jiang Zhou; Gang Tian; Ting Ye; Zhang-rui Zeng; Jian Deng; Hong Wan; Qing Li; Jin-bo Liu (Journal of Zhejiang University-SCIENCE B, 2020)

Cerebral Ischemia-Reperfusion Injury: Lysophosphatidic Acid Mediates Inflammation by Decreasing the Expression of Liver X Receptor - Xiaoyun Zeng; Zhixiu Luo; Junyi Wu; Jie Zhou; Yandong Shan; Yang Zhu; Guilin Yan; Yahang Lin; Chao Wang (Journal of Molecular Neuroscience, 2020)

Cu(OH)2 nanorods undergo sulfidation in water: in situ formation of CuO nanorods as intermediates and enhanced toxicity to Escherichia coli - Heming Su; Xiaoting Qian; Zhouhang Gu; Zhenlan Xu; Haijin Lou; Xinyun Bian; Tao Zeng; Daohui Lin; Juliane Filser; Lingxiangyu Li (Environmental Chemistry Letters, 2020)

Neo-debromoaplysiatoxin C, with new structural rearrangement, derived from debromoaplysiatoxin - Yang-Hua Tang; Ting-Ting Liang; Ting-Ting Fan; Lawrence Jordan Keen; Xiao-Dan Zhang; Lin Xu; Qi Zhao; Rong Zeng; Bing-Nan Han (Natural Product Research, 2020)

CO2 flux of soil respiration in natural recovering karst abandoned farmland in Southwest China - Yanwei Wang; Weijun Luo; Guangneng Zeng; Hanling Yang; Meifang Wang; Yina Lyu; Anyun Cheng; Lin Zhang; Xianli Cai; Jia Chen; Shijie Wang (Acta Geochimica, 2020)

The Potential Pollution Risk of Groundwater by a Ceramic Permeable Brick Paving System - Zi-Zeng Lin; Hui-Ming Chen; Hai Yang (Water, Air, & Soil Pollution, 2020)

Assessment of nutrient and heavy metal contamination in surface sediments of the Xiashan stream, eastern Guangdong Province, China - Weijie Li; Shu Lin; Wencai Wang; Zhiwei Huang; Hailong Zeng; Xianglin Chen; Fantang Zeng; Zhongya Fan (Environmental Science and Pollution Research, 2020)

Green chemistry: efficient acetalization of aldehydes with alcohols using the acid red 52 photocatalyst - Linyu Yu; Chuyuan Lin; Chunshu Liao; Xianghua Zeng; Xiuwen Chen; Zhongzhi Zhu; Yubing Huang; Yibiao Li; Lu Chen (Environmental Chemistry Letters, 2020)

Streptomyces taklimakanensis sp. nov., an actinomycete isolated from the Taklimakan desert - Lin-Lin Yuan; Li-Li Zhang; Xiao-Xia Luo; Zhan-Feng Xia; Bei-Bei Sun; Hong Zeng (Antonie van Leeuwenhoek, 2020)

New insight into the molecular phylogeny of the genus Liparis s.l. (Orchidaceae: Malaxideae) with a new generic segregate: Blepharoglossum - Lin Li; Shih-Wen Chung; Bo Li; Song-Jun Zeng; Hai-Fei Yan; Shi-Jin Li (Plant Systematics and Evolution, 2020)
Molecular studies have shown that Liparis s.l. is polyphyletic, with the epiphytic Liparis alliance well separated from the clade representing Liparis in its restricted sense and further forming a phylogenetically heterogeneous assemblage. The generic status of Cestichis , as the key member of the epiphytic Liparis alliance, remains contentious, and the relationships between Cestichis , Stichorkis and Platystyliparis are still unclear and in need of further studies. We herein employ DNA sequence data from nuclear ITS and plastid mat K regions to clarify the generic boundaries of Cestichis and its relationship to the allied genera. Results from both Bayesian inference and maximum likelihood analysis congruently indicate that Cestichis as currently circumscribed is not monophyletic. The Blepharoglossum clade, corresponding to commonly recognized sect. Blepharoglossum , forms a monophyletic lineage closely related to the genus Oberonia instead of the core Cestichis clade. A re-evaluation of the diagnostic morphological characters reveals that this lineage represents a morphologically distinct group. Based on these results, Blepharoglossum is removed from Cestichis and elevated to generic status. Our study also sheds light on the homoplastic nature of some diagnostic morphological characters used traditionally in the taxonomy of the Malaxidinae.

Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity - Joan Poh Ling Sim; Wang Ziyin; Adeline Henry Basil; Shuping Lin; Zhongcan Chen; Chengwu Zhang; Li Zeng; Yu Cai; Kah-Leong Lim (NeuroMolecular Medicine, 2020)
Mutations in LRRK2 are currently recognized as the most common monogenetic cause of Parkinsonism. The elevation of kinase activity of LRRK2 that frequently accompanies its mutations is widely thought to contribute to its toxicity. Accordingly, many groups have developed LRRK2-specific kinase inhibitors as a potential therapeutic strategy. Given that protein phosphorylation is a reversible event, we sought to elucidate the phosphatase(s) that can reverse LRRK2-mediated phosphorylation, with the view that targeting this phosphatase(s) may similarly be beneficial. Using an unbiased RNAi phosphatase screen conducted in a Drosophila LRRK2 model, we identified PP2A as a genetic modulator of LRRK2-induced neurotoxicity. Further, we also identified ribosomal S6 kinase (S6K), a target of PP2A, as a novel regulator of LRRK2 function. Finally, we showed that modulation of PP2A or S6K activities ameliorates LRRK2-associated disease phenotype in Drosophila .

Modulation of copper-induced antioxidant defense, Cu transport, and mitophagy by hypoxia in the large yellow croaker (Larimichthys crocea) - Yun Pan; Chun-Xiang Ai; Lin Zeng; Can Liu; Wen-Cheng Li (Fish Physiology and Biochemistry, 2020)

Development of a FRET-Based Assay for Analysis of mAbs Internalization and Processing by Dendritic Cells in Preclinical Immunogenicity Risk Assessment - Yi Wen; Suntara Cahya; Wei Zeng; Joanne Lin; Xiaoli Wang; Ling Liu; Laurent Malherbe; Robert Siegel; Andrea Ferrante; Arunan Kaliyaperumal (The AAPS Journal, 2020)

Detection of serum IgM and IgG for COVID-19 diagnosis - Ling Zhong; Junlan Chuan; Bo Gong; Ping Shuai; Yu Zhou; Yi Zhang; Zhilin Jiang; Dingding Zhang; Xiaoqi Liu; Shi Ma; Yi Huang; He Lin; et al. (Science China Life Sciences, 2020)

Clinical strategies for differentiating IgG4-related cholecystitis from gallbladder carcinoma to avoid unnecessary surgical resection - Rui Zhang; Hao-Ming Lin; Zhao-Xi Cai; Su-Juan Du; Hong Zeng; Lei-Bo Xu; Jie Wang; Chao Liu (Science China Life Sciences, 2020)

Optimal reduction of anthropogenic emissions for air pollution control and the retrieval of emission source from observed pollutants II: Iterative optimization using a positive-negative discriminant - Qingcun Zeng; Lin Wu; Kece Fei (Science China Earth Sciences, 2020)

Molecular cloning and characterization of five genes from embryogenic callus in Miscanthus lutarioriparius - Lingling Zhao; Xiaofei Zeng; Xiaohu Hu; Jiajing Sheng; Fenglin Zhu; Lin Zhong; Fasong Zhou; Surong Jin; Zhongli Hu; Ying Diao (Acta Physiologiae Plantarum, 2020)
The regeneration from embryogenic callus of higher plants in tissue culture is regulated by explants types and developmental stage and also regulated by some genes. In Miscanthus lutarioriparius , five candidate genes were selected to decide the differential expression between embryogenic and non-embryogenic calli, including MlARF-GEP (guanine nucleotide-exchange protein of ADP ribosylation factor), MlKHCP (kinesin heavy chain like protein), MlSERK1 (somatic embryogenesis receptor-like kinases 1), MlSERK2 (somatic embryogenesis reportor-like kinases 2), and MlTypA (tyrosine phosphorylation protein A) with Genbank accession numbers KU640196–KU640200. Multiple sequence alignment analysis showed that five genes were highly conserved among members of their gene families respectively. Phylogenetic relationship analysis showed that five genes were closest with homologous genes of Zea mays and Sorghum . The qRT-PCR results showed significant differences of five genes expression pattern between two different callus types, the relative expression in embryogenic callus was detected to exceed in non-embryogenic callus. Furthermore, simple sequence repeats (SSR) marker statistics results via Chi-square showed a significant correlation between MlSERK1 genotype and induction of embryogenic callus in M. lutarioriparius . This study may lay the foundation of the molecular mechanism on the embryogenic callus induction of M. lutarioriparius and perhaps provide some gist for further study on genetic manipulation.

Opportunistic bacteria use quorum sensing to disturb coral symbiotic communities and mediate the occurrence of coral bleaching - Jin Zhou; Zi‐Jun Lin; Zhong‐Hua Cai; Yan‐Hua Zeng; Jian‐Ming Zhu; Xiao‐Peng Du (Environmental Microbiology, 2020)
Summary Coral associated microorganisms, especially some opportunistic pathogens can utilize quorum‐sensing (QS) signals to affect population structure and host health. However, direct evidence about the link between coral bleaching and dysbiotic microbiomes under QS regulation was lacking. Here, using 11 opportunistic bacteria and their QS products (AHLs, acyl‐homoserine‐lactones), we exposed Pocillopora damicornis to three different treatments: test groups (A and B: mixture of AHLs‐producing bacteria and cocktail of AHLs signals respectively); control groups (C and D: group A and B with furanone added respectively); and a blank control (group E: only seawater) for 21 days. The results showed that remarkable bleaching phenomenon was observed in groups A and B. The operational taxonomic units‐sequencing analysis shown that the bacterial network interactions and communities composition were significantly changed, becoming especially enhanced in the relative abundances of Vibrio , Edwardsiella , Enterobacter , Pseudomonas , and Aeromonas . Interestingly, the control groups (C and D) were found to have a limited influence upon host microbial composition and reduced bleaching susceptibility of P. damicornis . These results indicate bleaching's initiation and progression may be caused by opportunistic bacteria of resident microbes in a process under regulation by AHLs. These findings add a new dimension to our understanding of the complexity of bleaching mechanisms from a chemoecological perspective.

Nanochemoprevention with therapeutic benefits: An updated review focused on epigallocatechin gallate delivery - Qiong-Qiong Yang; Xin-Lin Wei; Ya-Peng Fang; Ren-You Gan; Min Wang; Ying-Ying Ge; Dan Zhang; Li-Zeng Cheng; Harold Corke (Critical Reviews in Food Science and Nutrition, 2020)

Traits and their plasticity determine responses of plant performance and community functional property to nitrogen enrichment in a boreal peatland - Guigang Lin; De-Hui Zeng; Rong Mao (Plant and Soil, 2020)

The Potential Role of PKA/CREB Signaling Pathway Concerned with Gastrodin Administration on Methamphetamine-Induced Conditioned Place Preference Rats and SH-SY5Y Cell Line - Gen-Meng Yang; Lu Li; Feng-Lin Xue; Chen-Li Ma; Xiao-Feng Zeng; Yong-Na Zhao; Dong-Xian Zhang; Yang Yu; Qian-Wen Yan; Yi-Qing Zhou; Shi-Jun Hong; Li-Hua Li (Neurotoxicity Research, 2020)

Investigating the age composition of Indo-Pacific humpback dolphins in the Pearl River Estuary based on their pigmentation pattern - Lang Guo; Wenzhi Lin; Chen Zeng; Dingyu Luo; Yuping Wu (Marine Biology, 2020)

Attitudinal Barriers to Pain Management and Associated Factors Among Cancer Patients in Mainland China: Implications for Cancer Education - Dongyan Zeng; Kun Li; Xiyin Lin; Michiyo Mizuno (Journal of Cancer Education, 2020)

A survey of microbial contamination in aviation fuel from aircraft fuel tanks - Dong Hu; Jie Zeng; Shangshu Wu; Xi Li; Chengsong Ye; Wenfang Lin; Xin Yu (Folia Microbiologica, 2020)

Temporal variations in riverine hydrochemistry and estimation of the carbon sink produced by coupled carbonate weathering with aquatic photosynthesis on land: an example from the Xijiang River, a large subtropical karst-dominated river in China - Rui Yang; Hailong Sun; Bo Chen; Mingxing Yang; Qingrui Zeng; Cheng Zeng; Jie Huang; Huixian Luo; Danhui Lin (Environmental Science and Pollution Research, 2020)

Application of artificial neural network (ANN) and response surface methodology (RSM) for modeling and optimization of the contact angle of rice leaf surfaces - Jiantao Zhang; Gengchun Lin; Xuanchun Yin; Jiajun Zeng; Sheng Wen; Yubin Lan (Acta Physiologiae Plantarum, 2020)

Optimization and Evaluation of the Thermosensitive In Situ and Adhesive Gel for Rectal Delivery of Budesonide - Lin Chen; Xue Han; Xiaohong Xu; Quan Zhang; Yingchun Zeng; Qing Su; Yujie Liu; Yanmei Sheng; Xingliang Xie (AAPS PharmSciTech, 2020)

EDNRB Reverses Methylprednisolone-Mediated Decrease in Neural Progenitor Cell Viability via Regulating PI3K/Akt Pathway and lncRNA Expression - Shiyuan Li; Ming Zeng; Lin Yang; Jianqi Yang; Jianshao Tan; Hongye Guan; Manyuan Kuang (Journal of Molecular Neuroscience, 2020)

Correction to: Microsatellite records for volume 10, issue 2 - Dan Yu; Xueyun Ding; Zhi Zhang; Yu Zeng; Huanzhang Liu; Lin Wang; Ye Gong; Xingtu Liu; Xianguo Lyu; Gregory R. McCracken; Francisca V. Valenzuela-Aguayo; Evelyn M. Habit; et al. (Conservation Genetics Resources, 2020)

Dolphin-watching tourism and indo-Pacific humpback dolphins (Sousa chinensis) in Sanniang Bay, China: impacts and solutions - Haiping Wu; Chongwei Peng; Hu Huang; Thomas A. Jefferson; Shiang-Lin Huang; Mo Chen; Qianhui Zeng; Xueying Yu; Xianyan Wang; Youhou Xu (European Journal of Wildlife Research, 2020)

cDNA-AFLP analysis of differentially expressed genes during microspore embryogenesis in non-heading Chinese cabbage - Ya Zhang; Su-yan Gao; Huan-huan Liu; Xi-lin Zhang; Ai-song Zeng; Jian-jun Wang; Xi-lin Hou; Ying Li (In Vitro Cellular & Developmental Biology - Plant, 2020)

Influence of organic amendments used for benz[a]anthracene remediation in a farmland soil: pollutant distribution and bacterial changes - Qinghe Zhu; Yucheng Wu; Jun Zeng; Taolin Zhang; Xiangui Lin (Journal of Soils and Sediments, 2020)

Influence of humic acid and its different molecular weight fractions on sedimentation of nanoscale zero-valent iron - Yanan Wu; Haoran Dong; Lin Tang; Long Li; Yaoyao Wang; Qin Ning; Bin Wang; Guangming Zeng (Environmental Science and Pollution Research, 2020)

Probiotic Clostridium butyricum Improves the Growth Performance, Immune Function, and Gut Microbiota of Weaning Rex Rabbits - Lei Liu; Dong Zeng; Mingyue Yang; Bin Wen; Jing Lai; Yi Zhou; Hao Sun; Lvcheng Xiong; Jie Wang; Yicen Lin; Kangcheng Pan; Bo Jing; et al. (Probiotics and Antimicrobial Proteins, 2019)

Groundwater contaminant source identification via Bayesian model selection and uncertainty quantification - Tongtong Cao; Xiankui Zeng; Jichun Wu; Dong Wang; Yuanyuan Sun; Xiaobin Zhu; Jin Lin; Yuqiao Long (Hydrogeology Journal, 2019)

Mixed Infection of Toe Nail Caused by Trichosporon asahii and Rhodotorula mucilaginosa - Nur Fazleen Binti Idris; Guowang Huang; Qianying Jia; Lin Yuan; Yimin Li; Zeng Tu (Mycopathologia, 2019)

Tropical cyclone sensitivities to CO2 doubling: roles of atmospheric resolution, synoptic variability and background climate changes - Gabriel A. Vecchi; Thomas L. Delworth; Hiroyuki Murakami; Seth D. Underwood; Andrew T. Wittenberg; Fanrong Zeng; Wei Zhang; Jane W. Baldwin; Kieran T. Bhatia; William Cooke; Jie He; Sarah B. Kapnick; et al. (Climate Dynamics, 2019)

A new indole-type alkaloid from the roots of Clematis florida var. plena - Kai-Hui Sun; Xin-Hua Ma; Xian-Ming Zeng; Zhong-Yue Lin; Yu-Mei Cai; Hai-Tao Zhang; Xiao-Yan Lin; Shi-Biao Feng; Tian-Hua Zhong; Yong-Hong Zhang (Natural Product Research, 2019)

An integrated strategy to identify genes responsible for sesquiterpene biosynthesis in turmeric - Jingru Sun; Guanghong Cui; Xiaohui Ma; Zhilai Zhan; Ying Ma; Zhongqiu Teng; Wei Gao; Yanan Wang; Tong Chen; Changjiangsheng Lai; Yujun Zhao; Jinfu Tang; et al. (Plant Molecular Biology, 2019)

A New Neural Pathway from the Ventral Striatum to the Nucleus Basalis of Meynert with Functional Implication to Learning and Memory - Si Yun Shu; Gang Jiang; Zhaocong Zheng; Lin Ma; Bin Wang; Qiyi Zeng; Hong Li; Shen Tan; Bin Liu; Wood Yee Chan; Sheng Wu; Chunhua Zhu; et al. (Molecular Neurobiology, 2019)

Time-dependent impairments in learning and memory in Streptozotocin-induced hyperglycemic rats - Ayaz Ahmed; Guirong Zeng; Dejiang Jiang; Haiying Lin; Mudassar Azhar; Ahsana Dar Farooq; Muhammad Iqbal Choudhary; Xinmin Liu; Qiong Wang (Metabolic Brain Disease, 2019)

Excess copper effects on growth, uptake of water and nutrients, carbohydrates, and PSII photochemistry revealed by OJIP transients in Citrus seedlings - Qiang Li; Huan-Huan Chen; Yi-Ping Qi; Xin Ye; Lin-Tong Yang; Zeng-Rong Huang; Li-Song Chen (Environmental Science and Pollution Research, 2019)

Profiling the microbial contamination in aviation fuel from an airport - Dong Hu; Wenfang Lin; Jie Zeng; Peng Wu; Menglu Zhang; Lizheng Guo; Chengsong Ye; Kun Wan; Xin Yu (Biofouling, 2019)

Leaf Senescence can be Induced by Inhibition of Root Respiration - Gang-liang Tang; Xiang-yi Li; Li-sha Lin; Zhu-yu Gu; Fan-jiang Zeng (Journal of Plant Growth Regulation, 2019)

Study on Properties of Grouting Materials and Reinforcement Effect in Coal Roadways Influenced by Dynamic Pressure - Zeng-qiang Yang; Chang Liu; Yun Dong; Lin-ming Dou; Jing-ke Wu (Geotechnical and Geological Engineering, 2019)

Traction force-mediated B cell activation: how and why - Feng Lin; Junyi Wang; Yingyue Zeng; Chunyang Xiong; Wanli Liu (Science China Life Sciences, 2019)