Health Risk of Infants Exposed to Lead and Mercury Through Breastfeeding - Yung-Chieh Lin; Wei-Hsiang Chang; Tsun-Ching Li; Osuke Iwata; Hsiu-Ling Chen (Exposure and Health, 2023)
Donor milk from the human milk bank is important for vulnerable infants without their mothers’ own milk. Longitudinal changes in toxic metals in donor milk has not been reported. This study aimed to assess the effect of donors’ demographic characteristics, life habits and dietary habits on the concentration of metals in breastmilk donated to a human milk bank and to assess the health risk of lead (Pb) and mercury (Hg) exposure of donor mothers’ offspring through breastfeeding and the vulnerable recipients. A total of 228 samples, which were longitudinally donated to the human milk bank by 39 donors, were selected specifically to assess the levels of Pb, Hg, and MeHg. Donors’ offspring were also enrolled as mother-infant-dyads to monthly obtain the milk consumption and body weight. The results showed significant differences in the infant risk in exclusive breastfeeding months. The average Pb level of breast milk was 6.49 ± 5.23 µg/L (mean ± standard deviation), and the Hg level was 0.76 ± 0.98 µg/L. The sources of these toxins—residential districts, cleaning products, cosmetics, drinking water, viscera, eggs, seafood, and canned food—have a significant influence on the concentration of toxic metals in human milk. This study showed an unacceptable non-cancerous health risk (95th percentile hazard index, HI = 1.37 > 1) for Pb and Hg. In the future, the breast milk offered by the bank should be strictly monitored, especial for Pb, to ensure high-quality donor milk for vulnerable recipients but also donor mothers’ offspring who depend on it. Graphical Abstract

CPNE1 regulates myogenesis through the PERK-eIF2α pathway mediated by endoplasmic reticulum stress - Lin Chen; Ling Pan; Yuexi Zeng; Xiaonan Zhu; Li You (Cell and Tissue Research, 2023)
Sarcopenia is characterized by a progressive reduction in muscle mass or muscle physiological function associated with aging, but the relevant molecular mechanisms are not clear. Here, we identify the role of the myogenesis modifier CPNE1 in sarcopenia. CPNE1 is upregulated in aged skeletal muscles and young skeletal muscle satellite cells with palmitate-induced atrophy. The overexpression of CPNE1 hinders proliferation and differentiation and increases muscle atrophy characteristics in young skeletal muscle-derived satellite cells. In addition, CPNE1 overexpression disrupts the balance of mitochondrial fusion and division and causes endoplasmic reticulum stress. We found that the effects of CPNE1 on mitochondrial function are dependent on the PERK/eIF2α/ATF4 pathway. The overexpression of CPNE1 in young muscles alters membrane lipid composition, reduces skeletal muscle fibrosis regeneration, and exercise capacity in mice. These effects were reversed by PERK inhibitor GSK2606414. Moreover, immunoprecipitation indicates that CPNE1 overexpression greatly increased the acetylation of PERK. Therefore, CPNE1 is an important modifier that drives mitochondrial homeostasis to regulate myogenic cell proliferation and differentiation via the PERK-eIF2α pathway, which could be a valuable target for age-related sarcopenia.

Enhanced Lipid Productivity in Low-Starch Mutant of Monoraphidium sp. for Biodiesel Production - Yimeng Lin; Yunye Zhang; Yang Fan; Chang Li; Hongzhi Ling; Wenxiang Ping; Jingping Ge (BioEnergy Research, 2023)

Impact of environmental factors on diversity of fungi in sediments from the Shenzhen River Estuary - Wenzhen Lin; Xin Liu; Linfeng Gong; Ruzhen Liu; Minghuang Ling; Chiming Guo; Hongyan Meng; Zhuhua Luo; Xiaona Du; Ying Guo; Wei Xu (Archives of Microbiology, 2023)
In this study, to explore the relationship between environmental factors and fungal diversity in the Shenzhen River ecosystem, multiple methods including chemical analysis, culture isolation, qPCR analysis of fungal ITS region and ITS-based Illumina next-generation-sequencing were integrated. A total of 115 isolates were finally isolated and could be classified into 23 genera. Top three abundant genera isolated were Meyerozyma (18 strains), Aspergillus (17 strains) and Penicillium (14 strains). Based on the Illumina sequencing approach, 829 OTUs were affiliated to seven phyla, 17 known classes, and 162 genera, indicating the Shenzhen estuary sediments are rich in fungal diversity. The major fungal genera were Meyerozyma , Trichoderma and Talaromyces . Environmental factors showed a gradient change in Shenzhen estuary, and fungal abundance was only significantly correlated with NH 4 + . Shannon index was significantly correlated with pH and IC ( P

Ambient nitrogen dioxide and cardiovascular diseases in rural regions: a time-series analyses using data from the new rural cooperative medical scheme in Fuyang, East China - Teng-Fei Dong; Zhen-Qiu Zha; Liang Sun; Ling-Li Liu; Xing-Yang Li; Yuan Wang; Xiang-Long Meng; Huai-Biao Li; Hong-Li Wang; Huan-Huan Nie; Lin-Sheng Yang (Environmental Science and Pollution Research, 2023)

Carbon neutrality: a comprehensive bibliometric analysis - Lili Zhang; Jie Ling; Mingwei Lin (Environmental Science and Pollution Research, 2023)

DEHP mediates drug resistance by metabolic reprogramming in colorectal cancer cells - Yue Wu; Ruijie Lu; Yujie Lin; Jinjin Wang; Zijian Lou; Xiaochun Zheng; Ling Zhang; Ruolang Pan; Gang Lu; Qingxia Fang (Environmental Science and Pollution Research, 2023)
Long-term exposure to diethylhexyl phthalate (DEHP), an endocrine-disrupting chemical (EDCs) and plasticizer widely used in consumer products, has been reported to be significantly positively correlated with increased risks of different human diseases, including various cancers, while the potential effect of DEHP on colorectal cancer progression was little studied. In the present study, we showed that DEHP could trigger the metabolic reprogramming of colorectal cancer cells, promote cell growth and decrease fluorouracil (5-FU) sensitivity. Mechanistic studies indicated that DEHP could reduce glycolysis activity and increase oxidative phosphorylation (OXPHOS) in SW620 cells. In addition, in vivo experiments showed that DEHP promoted tumorigenic progression and decreased survival time in mice. Collectively, our findings suggest that DEHP may be a potent risk factor for colorectal cancer development.

Microbial response to antimony-arsenic distribution and geochemical factors at arable soil around an antimony mining site - Huayan Huang; Kangkai Lin; Ling Lei; Yongyun Li; Yipeng Li; Ke Liang; Yuxian Shangguan; Heng Xu (Environmental Science and Pollution Research, 2023)

Laboratory Studies of Internal Solitary Waves Propagating and Breaking over Submarine Canyons - Ying-Tien Lin; Ling Liu; Biyun Sheng; Yeping Yuan; Keke Hu (Journal of Marine Science and Engineering, 2023)
This paper carried out laboratory experiments to study evolution of internal solitary waves (ISWs) over submarine canyons with a combination of PIV (particle image velocimetry) and PLIF (planar laser-induced fluorescence) techniques. Taking canyon angle θ and collapse height ∆H as variables, Froude number Fr, head position, energy loss, vorticity field and turbulence intensity when ISWs propagate to the canyon were analyzed. According to the Froude number Fr values, the study cases can be divided into three types: Fr > 1.7 means complete internal hydraulic jump (IHJ); 1

Condition optimization of iron-air fuel cell to treat phosphate-containing wastewater regarding sustainable development - Ling-ling Lai; Chao Liu; Meng-yu Liu; Si-zhuo Wan; Zhi-guo Zhao; Ru Wang; Lin-jiang Yuan (Chemosphere, 2023)

Biotransformation of sulfamonomethoxine in a granular sludge system: Pathways and mechanisms - Meng-Yuan Li; Run-Dong Zhang; Yi-Xing Lin; Qi-Wen Li; Qiu-Yue Zhao; Zong-Xi Zhao; Zhong-Ming Ling; Long-Fei Shu; Min Zhang; Li-Xin Hu; Yi-Jing Shi; Guang-Guo Ying (Chemosphere, 2023)

Vitamin D serves as a modulator of immune organs in grass carp (Ctenopharyngodon idella) infected with Aeromonas hydrophila - Yao Zhang; Chao-Nan Li; Wei-Dan Jiang; Pei Wu; Yang Liu; Sheng-Yao Kuang; Ling Tang; Shu-Wei Li; Xiao-Wan Jin; Hong-Mei Ren; Xiao-Qiu Zhou; Lin Feng (Aquaculture, 2023)

Effects of dietary creatine levels on the growth, muscle energy metabolism and meat quality of spotted seabass (Lateolabrax maculatus) fed low-fishmeal diets - Jibin Lin; Yanqin Liao; Xueshan Li; Kangle Lu; Kai Song; Ling Wang; Lu Zhang; Chunxiao Zhang (Aquaculture, 2023)

Alleviation of hypoxia stress induced oxidative damage, endoplasmic reticulum stress (ERS) and autophagy in grass carp (Ctenopharyngodon idellu) by TTO (Melaleuca alternifolia essential oil) - Ruoying Hu; Shiyu Wang; Lin Feng; Weidan Jiang; Pei Wu; Yang Liu; Xiaowan Jin; Shengyao Kuang; Ling Tang; Lu Zhang; Xiaoqiu Zhou (Aquaculture, 2023)

RETRACTED: Boronic acid-modified bacterial cellulose microspheres as packing materials for enveloped virus removal - Zhiyang Lin; Linhan Li; Kaige Song; Bin Yang; Guoqing Zhou; Gengrong Zhang; Jiang Teng; Erlong Wang; Xiaoqiang Liu; Fei Ling; Gaoxue Wang; Tianqiang Liu (Science of The Total Environment, 2023)

Reducing manufacturing carbon emissions: Optimal low carbon production strategies respect to product structures and batches - Jun Zheng; Junjie Shi; Feng Lin; Xinyu Hu; Qi Pan; Tiening Qi; Yicheng Ren; Aizhi Guan; Zhiyi Zhang; Wei Ling (Science of The Total Environment, 2023)

Evaluation of a GNSS for wave measurement and directional wave spectrum analysis - Hanbin Gu; Xiaoan Zhu; Rui Shan; Jun Zang; Ling Qian; Pengzhi Lin (Ocean Engineering, 2023)

Monitoring cell viability in N-nitrosodiethylamine induced acute hepatitis and detection of hydrazine in solution and gas phase with Dual-function fluorescent probes - Youbo Lai; Tengteng Zhang; Ling Huang; Wenxiu Li; Weiying Lin (Journal of Hazardous Materials, 2023)

Covalent modification of soy protein hydrolysates by EGCG: Improves the emulsifying and antioxidant properties - Tianyi Wu; Ling Lin; Xinyi Zhang; Xinyue Wang; Jian Ding (Food Research International, 2023)

Evaluation of cold plasma for decontamination of molds and mycotoxins in rice grain - Jian Guo; Zhiping He; Chao Ma; Wanting Li; Jiaoyu Wang; Fucheng Lin; Xingquan Liu; Ling Li (Food Chemistry, 2023)

Using transcriptomics to reveal the molecular mechanism of higher alcohol metabolism in Saccharomyces cerevisiae - Danyao Cui; Ling Liu; Xiaoyuan Zhang; Liangcai Lin; Xin Li; Ting Cheng; Chunhui Wei; Yu Zhang; Zheng Zhou; Wei Li; Cuiying Zhang (Food Bioscience, 2023)

In vitro and in vivo anti-tumor activity of Antrodia salmonea against twist-overexpressing HNSCC cells: Induction of ROS-mediated autophagic and apoptotic cell death - Hsin-Ling Yang; Yi-An Lin; Sudhir Pandey; Jiunn-Wang Liao; Tzong-Der Way; Yu-lyu Yeh; Siang-Jyun Chen; You-Cheng Hseu (Food and Chemical Toxicology, 2023)

CH4 and CO2 emissions in water networks of rice cultivation regions - Ouping Deng; Jiangyou Ran; Xuesong Gao; Xiangjun Lin; Ting Lan; Ling Luo; Yalan Xiong; Jiang Liu; Dinghua Ou; Jianbo Fei; Rong Huang (Environmental Research, 2023)

Zeolite NaP1 synthesized from municipal solid waste incineration fly ash for photocatalytic degradation of methylene blue - Qian Chen; Yimeng Zhao; Qili Qiu; Ling Long; Xiaobo Liu; Shunda Lin; Xuguang Jiang (Environmental Research, 2023)

Multi-objective optimization of winter irrigation for cotton fields in salinized freeze-thaw areas - Ling Li; Hongguang Liu; Ping Gong; En Lin; Zhentao Bai; Pengfei Li; Chunxia Wang; Jing Li (European Journal of Agronomy, 2023)

Engineering metal–organic frameworks (MOFs) based thin-film nanocomposite (TFN) membranes for molecular separation - Die Ling Zhao; Fan Feng; Liguo Shen; Zhengyi Huang; Qipeng Zhao; Hongjun Lin; Tai-Shung Chung (Chemical Engineering Journal, 2023)

Facile synthesis of spiro-core-based hole-transporting material for high-performance and stable perovskite solar cells - Kun-Mu Lee; Seid Yimer Abate; June Hung Yang; Wei-Hao Chiu; Seoungjun Ahn; Sie-Rong Li; Kang-Ling Liau; Yu-Tai Tao; Yan-Duo Lin (Chemical Engineering Journal, 2023)

Experimental study on 3D source localization in indoor environments with weak airflow based on two bionic swarm intelligence algorithms - Axiang Chen; Yu Liao; Hao Cai; Xun Guo; Boyuan Zhang; Bencheng Lin; Wei Zhang; Ling Wei; Yan Tong (Building and Environment, 2023)

Analysis of microplastics released from plastic take-out food containers based on thermal properties and morphology study - Jia-Ling Hu; Yipin Duan; Huai-Ning Zhong; Qin-Bao Lin; Tianlong Zhang; Chuang-Chuang Zhao; Sheng Chen; Ben Dong; Dan Li; Jing Wang; Ming-Zhen Mo; Jie Chen; et al. (Food Additives & Contaminants: Part A, 2023)

Janus kinase inhibitor Tofacitinib alleviated acute hepatitis induced by lipopolysaccharide/D-galactosamine in mice - Xinyue Zhang; Ling Lin; Longjiang Li; Kai Hu; Ruyue Shao; Li Zhang; Li Tang; Min Zhu; Yuhua Ma; Yongqiang Yang (Molecular Biology Reports, 2023)

Automatic diagnosis of late-life depression by 3D convolutional neural networks and cross-sample Entropy analysis from resting-state fMRI - Chemin Lin; Shwu-Hua Lee; Chih-Mao Huang; Guan-Yen Chen; Wei Chang; Ho-Ling Liu; Shu-Hang Ng; Tatia Mei-Chun Lee; Shun-Chi Wu (Brain Imaging and Behavior, 2023)
Resting-state fMRI has been widely used in investigating the pathophysiology of late-life depression (LLD). Unlike the conventional linear approach, cross-sample entropy (CSE) analysis shows the nonlinear property in fMRI signals between brain regions. Moreover, recent advances in deep learning, such as convolutional neural networks (CNNs), provide a timely application for understanding LLD. Accurate and prompt diagnosis is essential in LLD; hence, this study aimed to combine CNN and CSE analysis to discriminate LLD patients and non-depressed comparison older adults based on brain resting-state fMRI signals. Seventy-seven older adults, including 49 patients and 28 comparison older adults, were included for fMRI scans. Three-dimensional CSEs with volumes corresponding to 90 seed regions of interest of each participant were developed and fed into models for disease classification and depression severity prediction. We obtained a diagnostic accuracy > 85% in the superior frontal gyrus (left dorsolateral and right orbital parts), left insula, and right middle occipital gyrus. With a mean root-mean-square error (RMSE) of 2.41, three separate models were required to predict depressive symptoms in the severe, moderate, and mild depression groups. The CSE volumes in the left inferior parietal lobule, left parahippocampal gyrus, and left postcentral gyrus performed best in each respective model. Combined complexity analysis and deep learning algorithms can classify patients with LLD from comparison older adults and predict symptom severity based on fMRI data. Such application can be utilized in precision medicine for disease detection and symptom monitoring in LLD.

Circ-BICC1 Knockdown Alleviates Lipopolysaccharide (LPS)-Induced WI-38 Cell Injury Through miR-338-3p/MYD88 Axis - Jing Wang; Guokai Li; Sheng Lin; Ling Cheng (Biochemical Genetics, 2023)

Associations between temperature variations and tourist arrivals: analysis based on Baidu Index of hot-spring tourism in 44 cities in China - Li Wang; Ling Xin; Yongjian Zhu; Yanyan Fang; Lin Zhu (Environmental Science and Pollution Research, 2023)

Tire wear particles: An emerging threat to soil health - Jing Ding; Min Lv; Dong Zhu; Eva F. Leifheit; Qing-Lin Chen; Yun-Qing Wang; Ling-Xin Chen; Matthias C. Rillig; Yong-Guan Zhu (Critical Reviews in Environmental Science and Technology, 2023)

Efficient removal of Sb(III) from water using β-FeOOH-modified biochar:Synthesis, performance and mechanism - Ling Lai; Xitao Liu; Wenbo Ren; Zhou Zhou; Xiwang Zhao; Xiaofeng Zeng; Chunye Lin; Mengchang He; Wei Ouyang (Chemosphere, 2023)

The beneficial effects of exogenous protease K originated from Parengyodontium album on growth performance of grass carp (Ctenopharyngodon idella) in relation to the enhanced intestinal digestion and absorption capacities - Ling Feng; Lin Feng; Wei-Dan Jiang; Yang Liu; Lu Zhang; Sheng-Yao Kuang; Hong-Mei Ren; Xiao-Wan Jin; Shu-Wei Li; Hai-Feng Mi; Xiao-Qiu Zhou; Pei Wu (Aquaculture, 2023)

Impaired intestinal physical barrier of on-growing grass carp by deficient iron under Aeromonas hydrophila infection - Yan-Lin Guo; Lin Feng; Wei-Dan Jiang; Pei Wu; Yang Liu; Sheng-Yao Kuang; Shu-wei Li; Ling Tang; Lu Zhang; Haifeng Mi; Xiao-Qiu Zhou (Aquaculture, 2023)

Water microecology is affected by seasons but not sediments: A spatiotemporal dynamics survey of bacterial community composition in Lake Changshou—The largest artificial lake in southwest China - Ai-ling Chen; Fu-qing Xu; Xia Su; Fu-pan Zhang; Wan-chao Tian; Shang-jie Chen; Fang Gou; Zhi-lin Xing; Jin-xin Xiang; Juan Li; Tian-tao Zhao (Marine Pollution Bulletin, 2023)

Composition of dissolved organic matter (DOM) in wastewater treatment plants influent affects the efficiency of carbon and nitrogen removal - Ling Wen; Fang Yang; Xuan Li; Siwan Liu; Yuye Lin; En Hu; Li Gao; Ming Li (Science of The Total Environment, 2023)

Potential of Miscanthus floridulus associated with endophytic bacterium Bacillus cereus BL4 to remediate cadmium contaminated soil - Xitong Wang; Shihua Luo; Yahui Chen; Renfeng Zhang; Ling Lei; Kangkai Lin; Chengshu Qiu; Heng Xu (Science of The Total Environment, 2023)

Triclosan in paired-maternal and cord blood, and their relationships with congenital heart disease of baby - Yu-Ling Luan; Yan-Qiu Ou; Xiao-Qing Liu; Shao Lin; Ying Guo (Science of The Total Environment, 2023)

Protolith origin of eclogites from the North Qaidam UHP metamorphic Belt, NW China: Implications for the breakup of the Rodinia supercontinent - Xiao-Dong Wang; Lin Ding; Deng Zeng; Ya-Hui Yue; Ling-Ping Yang; Zhe-Jun Wang; Lu-An Xiao; Chao Wang (Precambrian Research, 2023)

A constant parameter time domain model for dynamic modelling of multi-body system with strong hydrodynamic interactions - Meiyan Zou; Mingsheng Chen; Ling Zhu; Lin Li; Wenhua Zhao (Ocean Engineering, 2023)

Dietary cinnamaldehyde improves muscle protein content by promoting muscle fiber growth via PTP1B/IGF1/PI3K/AKTs-TOR/FOXO3a signaling pathway in grass carp (Ctenopharyngodon idella) - Yang Zhou; Pei Wu; Wei-Dan Jiang; Yang Liu; Yan Peng; Sheng-Yao Kuang; Ling Tang; Shu-Wei Li; Lin Feng; Xiao-Qiu Zhou (Food Chemistry, 2023)

Sustainable approaches on industrial food wastes to value-added products – A review on extraction methods, characterizations, and its biomedical applications - Arul Jayanthi Antonisamy; Sivasankari Marimuthu; Sankar Malayandi; Karthikeyan Rajendran; Yuan-Chung Lin; Gangadhar Andaluri; Siew Ling Lee; Vinoth Kumar Ponnusamy (Environmental Research, 2023)

Spontaneous granulation of moderately halophilic sludge inoculated with saltern sediments from single granule into multi-granule aggregation - Ling Wang; You-Wei Cui; Li Jian; Jia-Lin Yao (Environmental Research, 2023)

Eukaryotic plankton community assembly and influencing factors between continental shelf and slope sites in the northern South China Sea - Tangcheng Li; Guilin Liu; Huatao Yuan; Jianwei Chen; Xin Lin; Hongfei Li; Liying Yu; Cong Wang; Ling Li; Yunyun Zhuang; Lin Senjie (Environmental Research, 2023)

The association of long-term ambient fine particulate matter exposure with blood pressure among Chinese adults - Zhennan Lin; Shufeng Chen; Fangchao Liu; Jianxin Li; Jie Cao; Keyong Huang; Fengchao Liang; Jichun Chen; Hongfan Li; Jianfeng Huang; Dongsheng Hu; Chong Shen; et al. (Environmental Pollution, 2023)

The in-depth revelation of the mechanism by which a downflow Leersia hexandra Swartz constructed wetland-microbial fuel cell synchronously removes Cr(VI) and p-chlorophenol and generates electricity - Yian Wang; Xuehong Zhang; Ling Xiao; Hua Lin (Environmental Research, 2023)

Triggering of ST-elevation myocardial infarction by ultrafine particles in New York: Changes following Tier 3 vehicle introduction - Catherine S. Yount; Mark J. Utell; Philip K. Hopke; Sally W. Thurston; Shao Lin; Frederick S. Ling; Yunle Chen; David Chalupa; Xinlei Deng; David Q. Rich (Environmental Research, 2023)

Vanadium isotope evidence for widespread marine oxygenation from the late Ediacaran to early Cambrian - Wei Wei; Xi Chen; Hong-Fei Ling; Fei Wu; Lin-Hui Dong; Songqi Pan; Zhenhua Jing; Fang Huang (Earth and Planetary Science Letters, 2023)

Water-assistant ultrahigh fluorescence enhancement in perovskite polymer-encapsulated film for flexible X-ray scintillators - Yue Li; Qian-Li Li; Yan Li; Yun-Ling Yang; Shao-Lin Zhang; Jingtai Zhao; Jieqiong Wan; Zhijun Zhang (Chemical Engineering Journal, 2023)

Alleviating the self-discharge and enhancing the polysulphides conversion kinetics with LaCO3OH nanocrystals decorated hierarchical porous carbon - Yuhang Lin; Weiqiang Tang; Siyu Wu; Yongzheng Zhang; Zhenkai Kong; Chunyin Shen; Yanli Wang; Liang Zhan; Licheng Ling (Chemical Engineering Journal, 2023)

An S-scheme CdS/K2Ta2O6 heterojunction photocatalyst for production of H2O2 from water and air - Cui Lai; Mengyi Xu; Fuhang Xu; Bisheng Li; Dengsheng Ma; Yixia Li; Ling Li; Mingming Zhang; Danlian Huang; Lin Tang; Shiyu Liu; Huchuan Yan; et al. (Chemical Engineering Journal, 2023)

Activation of peroxymonosulfate via peroxyborate: Electrophilic substitution induced strong electrophile generation process - Hanxuan Zeng; Xiao Ling; Jing Deng; Lin Deng; Haojie Zhang; Tao Shi; Shiqing Zhou; Zhou Shi (Chemical Engineering Journal, 2023)

Thin-walled vesicular Triazole-CN-PDI with electronic n→π* excitation and directional movement for enhanced atrazine photodegradation - Rongdi Tang; Hao Zeng; Daoxin Gong; Yaocheng Deng; Sheng Xiong; Ling Li; Zhanpeng Zhou; Jiajia Wang; Chengyang Feng; Lin Tang (Chemical Engineering Journal, 2023)

Dimerization induces bimodality in protein number distributions - Ming-Yang Ling; Lin-Jie Chiu; Ching-Chu Hsieh; Che-Chi Shu (BioSystems, 2023)

Gas-phase and PM2.5-bound phthalates in nail salons: characteristics, exposure via inhalation, and influencing factors - Chia-Ling Chang; Hui-Tzu Chen; Chung-Yu Chen; En-Yu Chen; Kuan-Ting Lin; Chien-Cheng Jung (Environmental Science and Pollution Research, 2023)

Facile fabrication of a 2D/2D CoFe-LDH/g-C3N4 nanocomposite with enhanced photocatalytic tetracycline degradation - Mengxue Li; Mengmeng Chen; Stephanie Ling Jie Lee; Sijie Lin (Environmental Science and Pollution Research, 2023)

Transcriptome Analysis Provides an Overview of Genes Involved in the Peculiar Food Preference at First-Feeding Stage in Mandarin Fish (Siniperca chuatsi) - Ling Li; Shu-Lin Tang; Shan He; Xu-Fang Liang (Fishes, 2022)
The mandarin fish (Siniperca chuatsi) is an important economic fish species in China. Many carnivorous fish larvae feed on zooplankton or microdiets. However, the mandarin fish larvae feed on live prey fish exclusively, while refusing zooplankton or microdiets. A stable supply of palatable live prey fish results in high costs. Moreover, the application of live prey fish might bring the risk of pathogens. However, little is known about the genes underlying the food preference of mandarin fish larvae. Partial offspring of the domesticated strain could feed brine shrimp from three days post-hatching (dph), the open mouth day. In the present study, the mandarin fish larvae were randomly divided into three groups, then treated differently at 3 dph: (1) unfed; (2) fed with live prey fish; (3) fed with brine shrimp (Artemia). Differentially expressed genes were identified by RNA-seq. The differential expression of the transcription factors involved in retinal photoreceptor development and differentiation might contribute to the intake of brine shrimp in mandarin fish larvae. Meanwhile, the digestive enzyme genes involved in protein, fat, and carbohydrate digestion have been expressed in mandarin fish larvae at 3 dph, contributing to the digestion of ingested food. Our study provides an overview of genes and biological processes involved in the peculiar food preference at the first-feeding stage in mandarin fish larvae and has critical importance to the future application of non-fish live feeds in the culture of mandarin fish larvae.

The effects of extracellular algicidal compounds of Bacillus sp. B1 on Heterosigma akashiwo: a metabolomics approach - Xuanyue Li; Zehong Lin; Meiyi Yuan; Ling Zhao; Pinghe Yin (Environmental Science and Pollution Research, 2022)

Temporal and spatial characteristics of green total factor productivity in energy-intensive industry in China - Jinxian Lin; Ling Zhang (Environmental Science and Pollution Research, 2022)

Mesenchymal Stem Cell Secreted-Extracellular Vesicles are Involved in Chondrocyte Production and Reduce Adipogenesis during Stem Cell Differentiation - Yu-Chen Tsai; Tai-Shan Cheng; Hsiu-Jung Liao; Ming-Hsi Chuang; Hui-Ting Chen; Chun-Hung Chen; Kai-Ling Zhang; Chih-Hung Chang; Po-Cheng Lin; Chi-Ying F. Huang (Tissue Engineering and Regenerative Medicine, 2022)
Background: Extracellular vesicles (EVs) are derived from internal cellular compartments, and have potential as a diagnostic and therapeutic tool in degenerative disease associated with aging. Mesenchymal stem cells (MSCs) have become a promising tool for functional EVs production. This study investigated the efficacy of EVs and its effect on differentiation capacity. Methods: The characteristics of MSCs were evaluated by flow cytometry and stem cell differentiation analysis, and a production mode of functional EVs was scaled from MSCs. The concentration and size of EVs were quantitated by Nanoparticle Tracking Analysis (NTA). Western blot analysis was used to assess the protein expression of exosome-specific markers. The effects of MSC-derived EVs were assessed by chondrogenic and adipogenic differentiation analyses and histological observation. Results: The range of the particle size of adipose-derived stem cells (ADSCs)- and Wharton’s jelly -MSCs-derived EVs were from 130 to 150 nm as measured by NTA, which showed positive expression of exosomal markers. The chondrogenic induction ability was weakened in the absence of EVs in vitro . Interestingly, after EV administration, type II collagen, a major component in the cartilage extracellular matrix, was upregulated compared to the EV-free condition. Moreover, EVs decreased the lipid accumulation rate during adipogenic induction. Conclusion: The results indicated that the production model could facilitate production of effective EVs and further demonstrated the role of MSC-derived EVs in cell differentiation. MSC-derived EVs could be successfully used in cell-free therapy to guide chondrogenic differentiation of ADSC for future clinical applications in cartilage regeneration.

Comparison of ticagrelor and clopidogrel on platelet function and prognosis in unstable angina - Chun Li; Ming Liu; Weixiang Chen; Tingbo Jiang; Lin Ling (European Journal of Clinical Pharmacology, 2022)
Purpose This study aims to compare the effects of ticagrelor and clopidogrel on platelet function, cardiovascular prognosis, and bleeding in patients with unstable angina pectoris. Methods Patients with unstable angina pectoris undergoing percutaneous coronary intervention (PCI) were enrolled (January 2018–December 2019). In total, 212 patients were treated with ticagrelor (90 mg twice daily) and 210 patients were treated with clopidogrel (75 mg once daily). Thromboelastography and light transmission aggregometry were used to measure the platelet aggregation rate (PAR). High-sensitivity troponin T (hs-TnT), pro-brain natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (CRP), and heart-type fatty acid–binding protein (h-FABP) were measured to assess myocardial injury after PCI. Cardiovascular prognosis and bleeding events were evaluated in hospital and 12 months after discharge. Results The PAR was significantly slower with ticagrelor ( P < 0.001). hs-TnT, NT-proBNP, CRP, and h-FABP increased after compared with before PCI in both groups ( P < 0.05). hs-TnT ( P < 0.001) and h-FABP ( P < 0.001) increased more significantly with clopidogrel. The in-hospital and 12-month major adverse cardiovascular event (MACE) rates were not significantly different between the two groups. The in-hospital total bleeding event rate was higher with ticagrelor ( P < 0.05). Minor bleeding and total bleeding were more frequent at the 12-month follow-up in the ticagrelor group ( P < 0.05). Conclusion Ticagrelor was more effective in suppressing the PAR than clopidogrel and reduced PCI-induced myocardial injury in patients with unstable angina pectoris. However, it increased in-hospital and 12-month bleeding events and had no benefit on in-hospital and 12-month MACEs.

Enhanced visible light-driven photodegradation of tetracycline by salicylic acid-modified graphitic carbon nitride and toxicity assessment - Mengmeng Chen; Mengxue Li; Peng Li; Stephanie Ling Jie Lee; Juanjuan Tang; Qian Li; Sijie Lin (Environmental Science and Pollution Research, 2022)

Evaluation of the Madden-Julian Oscillation in Fengyun-3B Polar-Orbiting Satellite Reprocessed OLR Data - Hainan Gong; Wanchun Zhang; Ling Sun; Zizhen Dong; Peng Zhang; Lin Wang; Wen Chen; Renguang Wu (Journal of Meteorological Research, 2022)

Identification of the Hub Genes and the Signaling Pathways in Human iPSC-Cardiomyocytes Infected by SARS-CoV-2 - Li-Min Xie; Yin-Fei Huang; Ye-Ling Liu; Jia-Qi Liang; Wei Deng; Geng-Ling Lin; Huan-Min Luo; Xu-Guang Guo (Biochemical Genetics, 2022)

Two new phenylpropenoid glycosides from the roots of Illicium dunnianum - Yi-lin Wang; Han Li; Ling Song; Yun-hang Gao; Teng-fei Chen (Natural Product Research, 2022)

A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer - Chang Gong; Ziliang Cheng; Yaping Yang; Jun Shen; Yingying Zhu; Li Ling; Wanyi Lin; Zhigang Yu; Zhihua Li; Weige Tan; Chushan Zheng; Wenbo Zheng; et al. (Science China Life Sciences, 2022)

ACC deaminase-encoding Pseudomonas putida arrests seed germination: an alternative strategy for grass and weed control - Di Zhou; Jia-Ling Zhao; Rui Wang; Hai-Lin Wang; Daniela D. Herrera-Balandrano; Tang-Min Chen; Xiao-Feng Lu; Xu-Chu Duan; Mahdi Shahriar; Xin-Chi Shi; Pedro Laborda; Su-Yan Wang (Plant and Soil, 2022)

Effects of Biocontrol Agents Application on Soil Bacterial Community and the Quality of Tobacco - Zhongkui Li; Yulan Chen; Aifen Ling; Hongli Li; Zhengquan Lin; Yan Wang (Current Microbiology, 2022)

Xenoestrogen Status of Wuling Farm to Surrounding Water Bodies: An Application of Biochemical Parameters Using Onychostoma barbatulum - Lin-Yan Liao; Hui-Ling Cheng; Shu-Yin Wang; Shih-Hsiung Liang; Da-Ji Huang (Journal of Marine Science and Engineering, 2022)
The aim of this study was to apply biochemical parameters to Onychostoma barbatulum to understand whether Wuling Farm activities have caused organic pollution from xenoestrogens to flow into surrounding streams and thereby affected area aquatic ecosystems. Individuals of the Taiwan shovel-jaw carp (O. barbatulum) were collected by fyke netting in the Cijiawan, Kaoshan, and Yusheng Rivers in the protected area of Shei-Pa National Park and in the Ikawan River outside the protected areas from 4–5 June 2015 to 20–21 September 2015. The collected male individuals of O. barbatulum were divided into two groups. In the first group monooxygenase (Mon) activity, glutathione S-transferase (GST) activity, and vitellogenin (VTG) concentration in the liver were measured right after they were captured. Those in the second group were acclimated for 14 days and then exposed to 0 (control) or 10 ng/L 17β-estradiol for 10 days and then measured for changes in Mon, GST, and VTG in their livers. The value of VTG concentrations in O. barbatulum individuals collected from the Ikawan River was 2.12 ± 1.62 μg PO42+/g protein, which was the highest among all samples, followed by those collected from the Yusheng River (0.78 ± 1.00 μg PO42+/g protein). Individuals collected from the Yusheng River had the highest liver Mon activity (4.16 ± 1.08△A650/30 min/g protein) and the highest GST activity (1.58 ± 1.13 △A340/20 min/g protein), followed by those from the Ikawan River (Mon: 3.63 ± 1.13 △A650/30 min/g protein; GST: 1.24 ± 0.73 △A340/20 min/g protein). Comprehensive analyses showed that Mon and GST activities and VTG concentrations in livers measured right after being collected were lower than individuals exposed to 10 ng 17β-estradiol/L in the laboratory. Induced VTG concentrations were 9.87 ± 0.89 μg PO42+/g protein, Mon activity 8.02 ± 1.74 △A650/30 min/g protein, and GST activity 3.24 ± 0.62 △A340/20 min/g protein, indicating that farming activities have not significantly affected these aquatic organisms. However, pollution sources are still releasing pollutants containing xenoestrogens into the Yusheng River and Ikawan River. The impact of xenoestrogens is worthy of continuous long-term follow-up monitoring.

Vitamin D regulates transepithelial acid secretion in zebrafish (Danio rerio) larvae - Chia-Hao Lin; Sian-Tai Liu; Yu-Chun Wang; Yi-Ling Tsou; Huei-Jyun Hu (Frontiers in Marine Science, 2022)
Maintenance of an acid-base balance is essential for normal physiological processes in vertebrates. Freshwater fishes live in an aquatic environment with variable pH, and their buffering capacity for acid-base balance in body fluids is weak. Thus, after acid exposure, fishes secrete excess acid to prevent internal acidosis. Acid-secreting ionocytes present in the adult gills and embryonic skin are primarily responsible for acid secretion, and H + -ATPase and Na + /H + exchanger 3 (NHE3) are the two main transporters responsible for apical acid secretion. Vitamin D is a well-known hormone involved in the maintenance of Ca 2+ homeostasis and is suggested to be involved in acid-base regulation by modulating the activity and/or mRNA expression of NHE3 in mammalian models. It remains unclear whether vitamin D is involved in acid secretion in fishes. The aim of the present study was to use zebrafish as a model to determine whether vitamin D and its receptors influence acid secretion. Our results indicated that the levels of 1α, 25-dihydroxyvitamin D 3 (1α,25(OH) 2 D 3 ), the bioactive vitamin D, were significantly increased in 3 days post-fertilization zebrafish larvae after exposure to acidic freshwater (AFW, pH 4.0). Exogenous 1α,25(OH) 2 D 3 (20 μg/L) incubation substantially enhanced the mRNA expression of acid-secreting transporters and acid secretion at the skin of the entire body and each H + -ATPase-rich cell (HRC), a type of acid-secreting ionocyte. Furthermore, the expression of vitamin D receptors (VDRs) was identified in HRCs of zebrafish. When both VDRa and VDRb were knocked down, acid secretion and the mRNA expression of acid-secreting transporters were significantly decreased. Moreover, double knockdown of VDRa/b prevented the increase in acid secretion induced by AFW and 1α,25(OH) 2 D 3 treatment. This study is the first to indicate that vitamin D is involved in acid secretion in fish.

Tumor immune checkpoints and their associated inhibitors - Zerui Gao; Xingyi Ling; Chengyu Shi; Ying Wang; Aifu Lin (Journal of Zhejiang University-SCIENCE B, 2022)

A novel mutation in HINT1 gene causes autosomal recessive axonal neuropathy with neuromyotonia, effective treatment with carbamazepine and review of the literature - Ling Xu; Guangyu Wang; Xiaoqing Lv; Dong Zhang; Chuanzhu Yan; Pengfei Lin (Acta Neurologica Belgica, 2022)

Shallow-water hydrothermal vent system as an extreme proxy for discovery of microbiome significance in a crustacean holobiont - Ling Chiu; Min-Chen Wang; Kuang-Yu Tseng; Chih-Lin Wei; Huei-Ting Lin; Shan-Hua Yang; Yung-Che Tseng (Frontiers in Marine Science, 2022)
The shallow-water hydrothermal vent (HV) system off Kueishan Island lies at the end of the Okinawa Trough to the northeast of Taiwan. Near its submarine vent openings, aperiodic vent discharges generate a dynamic acidic (pH 5.5-8.1) and sulfidic (9-3000 μM) ecosystem. The dominant metazoan in this unique environment is the brachyuran vent crab, Xenograpsus testudinatus , which has developed robust metabolic strategies and highly adaptive acid-base regulatory mechanisms to maintain its physiological homeostasis. X. testudinatus is considered a holobiont, but the symbiotic mechanisms underlying acid and sulfur tolerance in the host-microbe system remain largely unclear. In this study, we used LoopSeq long-read sequencing of the full-length 16S rRNA gene to identify the bacterial communities present in the gills and carapace surface of X. testudinatus . The alpha diversity analysis, Venn diagram, and principal coordinate analysis (PCoA) indicated that the gills and carapace surface exhibit different bacterial constituents. Further measurements of relative abundance, coupled with functional predictions and fluorescence in situ hybridization (FISH), revealed a predominance of Sulfurovum sp. NBC37-1, a key bacterium that can perform sulfur and hydrogen oxidation to support denitrification processes. Consequently, our findings suggest that the symbiotic bacteria may play a critical role in conferring the extraordinary acid and sulfur tolerances of X. testudinatus , allowing the crustacean holobiont to thrive in its ecological niche within one of the most extreme marine habitats on Earth.

Wheat genomic study for genetic improvement of traits in China - Jun Xiao; Bao Liu; Yingyin Yao; Zifeng Guo; Haiyan Jia; Lingrang Kong; Aimin Zhang; Wujun Ma; Zhongfu Ni; Shengbao Xu; Fei Lu; Yuannian Jiao; et al. (Science China Life Sciences, 2022)

Altered Retinal Dopamine Levels in a Melatonin-proficient Mouse Model of Form-deprivation Myopia - Kang-Wei Qian; Yun-Yun Li; Xiao-Hua Wu; Xue Gong; Ai-Lin Liu; Wen-Hao Chen; Zhe Yang; Ling-Jie Cui; Yun-Feng Liu; Yuan-Yuan Ma; Chen-Xi Yu; Furong Huang; et al. (Neuroscience Bulletin, 2022)

Two new clerodane diterpenoids and a new pyran-2-one derivative with anti-neuroinflammatory activities from Croton crassifolius - Zhi-Peng Ling; Qing Tang; Can-Jie Li; Jin-Lin Tan; Hai-Yue Zhao; Yi-Kun Hao; Zhao-Chun Zhan; Zhong-Nan Wu; Yu-Bo Zhang; Qing Zheng; Guo-Cai Wang (Journal of Natural Medicines, 2022)

Environmental Kuznets curve for biodiversity loss: evidence from South and Southeast Asian countries - Yan-Ling Tan; Thian-Hee Yiew; Lin-Sea Lau; Ai-Lian Tan (Environmental Science and Pollution Research, 2022)

Stabilization of coarse-grained saline soil using microbially enhanced calcium carbonate deposition - Shengyi Cong; Liang Tang; Bo Wang; Xianzhang Ling; Lin Geng; Wenqiang Xing (Bulletin of Engineering Geology and the Environment, 2022)

Monitoring glaciers in the Chenab basin with SBAS InSAR technology - Yue-kai Ding; Rui Liu; Yi-fei Fan; Ling-xiang Zhou; Qin Ji; Hong Zhang; Zuo-lin Xiao (Journal of Mountain Science, 2022)

Vibrio salinus sp. nov., a marine nitrogen-fixing bacterium isolated from the lagoon sediment of an islet inside an atoll in the western Pacific Ocean - Wei-Sheng Huang; Li-Ting Wang; Jwo-Sheng Chen; Yen-Ting Chen; Sean Ting-Shyang Wei; Yin-Ru Chiang; Pei-Ling Wang; Tzong-Huei Lee; Shih-Ting Lin; Lina Huang; Wung Yang Shieh (Antonie van Leeuwenhoek, 2022)

Coastal aquaculture farms for the sea cucumber Apostichopus japonicus provide spawning and first-year nursery grounds for wild black rockfish, Sebastes schlegelii: A case study from the Luanhe River estuary, Bohai bay, the Bohai Sea, China - Min Xu; Zun-li Qi; Zun-lei Liu; Wei-min Quan; Qi Zhao; Yun-ling Zhang; Hui Liu; Lin-lin Yang (Frontiers in Marine Science, 2022)
Aquaculture farms are known to attract wild organisms from nearby areas. Sea cucumber Apostichopus japonicus aquaculture farms in Bohai Bay, the Bohai Sea, China, might provide spawning and nursery grounds for wild black rockfish Sebastes schlegelii populations. To identify the above, we studied the variation in the numbers of S. schlegelii larvae (and length-categories as a percentage of the natural population) via ichthyoplankton surveys by months from January to October 2020, and assessed the food web structure and energy flow distribution of the farm and trophic links of S. schlegelii natural stock by using Ecopath modeling in July 2016 to August 2017. Larvae with a length between 3.90-5.80 mm were observed in the farm in May 2020, the juveniles with an estimated trophic level of 4.31. Juveniles used the farms as first-year nursery ground, and then they swam into deeper waters in August of the following year. MTI analysis showed increasing biomass of S. schlegelii might result in a decrease in the biomass of crustacea, and had positive and negative impacts on mollusk and Hexagrammos otakii biomass. We argued that aquacultural infrastructures constructed by artificial reefs could be used as a fisheries management tool to enhance S. schlegelii stocks and that monitoring of other marine organisms, such as oysters, Rapana venosa , Charybdis japonica , and Asterias spp. etc., was necessary to maintain sustainable exploitations of aquacultural farm ecosystems. A paucity of knowledge surrounding the interactions between aquaculture farms and wild organisms needs furthermore researches.

First report of Pectobacterium colocasium causing bacterial soft rot of taro in Taiwan - Pei-Rong Lin; Chao-Ling Ting; Yun-Ching Sun; Chien-Jui Huang (Journal of Plant Pathology, 2022)

Extended Middle Cerebral Artery Occlusion (MCAO) Model to Mirror Stroke Patients Undergoing Thrombectomy - Sarah J. Messmer; Kathleen E. Salmeron; Jacqueline A. Frank; Christopher J. McLouth; Douglas E. Lukins; Tyler C. Hammond; Ai-Ling Lin; Justin F. Fraser; Keith R. Pennypacker (Translational Stroke Research, 2022)

A strategy for establishing an efficient somatic embryo regeneration system in Castanea mollissima Blume - Xiao-wei Li; Zhi-lin Sun; Yue-rong Gao; Jing-yi Ge; Yu-zhen Tian; Bing Liu; Shi-kan Sun; Ke-feng Fang; Ling Qin; Qing-qin Cao (Plant Cell, Tissue and Organ Culture (PCTOC), 2022)

Biomechanical Effects of Bone Atrophy, Implant Design, and Vertical or Tilted of Posterior Implant on All-on-Four Concept Implantation: Finite Element Analysis - Heng-Li Huang; Ting-Wei Lin; Hui-Ling Tsai; Yu-Ling Wu; Aaron Yu-Jen Wu (Journal of Medical and Biological Engineering, 2022)

Impact of air pollutants on hospital visits for pediatric asthma in Fuzhou city, southeast China - Quan Zhou; Shu-Ling Kang; Xin Lin; Xiao-Yang Zhang (Environmental Science and Pollution Research, 2022)

Lelliottia steviae sp. nov. isolated from Stevia rebaudiana Bertoni - Jing Lin; Ke Huang; Jing-Yu Huang; Yuan-Ru Xiong; Meng-Meng Wei; Na Xiao; Jia Gao; Xuan-Kai Ding; Zi-Yang Ma; Jun-Hao Sang; Ling-Xian Kong; Zhi-Yun Hong; et al. (Archives of Microbiology, 2022)

Halomonas salinarum sp. nov., a moderately halophilic bacterium isolated from saline soil in Yingkou, China - Ya-Lin Yin; Fang-Ling Li; Lei Wang (Archives of Microbiology, 2022)

A multi-isotope analysis on human and pig tooth enamel from prehistoric Sichuan, China, and its archaeological implications - Kuei-chen Lin; Cheng-Yi Lee; Pei-Ling Wang (Archaeological and Anthropological Sciences, 2022)

Fissistiganoids A and B: two new flavonoids from the Fissistigma tungfangense - Wan-Lin Zhong; Xue-Ming Zhou; Ji-Ling Yi; Xin-Ming Song; Bin Zhang; Jing-Yu Yang; Guang-Ying Chen (Natural Product Research, 2022)

Efficient de novo assembly and modification of large DNA fragments - Shuangying Jiang; Yuanwei Tang; Liang Xiang; Xinlu Zhu; Zelin Cai; Ling Li; Yingxi Chen; Peishuang Chen; Yuge Feng; Xin Lin; Guoqiang Li; Jafar Sharif; et al. (Science China Life Sciences, 2022)

Fine particulate matter measured by satellites predicts the risk of age-related macular degeneration in a longitudinal cohort study - Chung-Ling Liang; Chi-Min Wang; Chau-Ren Jung; Ya-Chu Chang; Chun-Ju Lin; Yu-Ting Lin; Bing-Fang Hwang (Environmental Science and Pollution Research, 2022)

Dynamics of soil organic carbon in different-sized aggregates under splash erosion - Junqiu Lin; Nufang Fang; Yan Zhang; Yi Zeng; Daming Yang; Wei Dai; Ling Wang; Zhihua Shi (Journal of Soils and Sediments, 2022)

TREM-2 mediates dendritic cell–induced NO to suppress Th17 activation and ameliorate chronic kidney diseases - Ching-Cheng Lin; Ti-Yung Chang; Yong-Chen Lu; Yun-Syuan Wu; Wei Huang; Wei-Chi Lo; Guan-Fu Liu; Wei-Chan Hsu; Pamela S. Ohashi; Tak W. Mak; Jong-Ling Fuh; Hui-Chen Chen; et al. (Journal of Molecular Medicine, 2022)

Evaluation of PET List Data-Driven Gated Motion Correction Technique Applied in Lung Tumors - Yi-Lun Chen; Bang-Hung Yang; I.-Ling Shih; Ko-Han Lin (Journal of Medical and Biological Engineering, 2022)

Use of piggyBac Transposon System Constructed Murine Breast Cancer Model for Reporter Gene Imaging and Characterization of Metastatic Tumor Cells - Ying-Ling Chen; Yung-Cheng Wang; Kuei-Yuan Hou; Min-Ying Lin; Yu-Chuan Lin; Hui-Yen Chuang; Yi-Jang Lee (Journal of Medical and Biological Engineering, 2022)

Astragalus Polysaccharides Reduce High-glucose-induced Rat Aortic Endothelial Cell Senescence and Inflammasome Activation by Modulating the Mitochondrial Na+/Ca2+ Exchanger - Xin-Yu Miao; Xiao-Xiao Zhu; Zhao-Yan Gu; Bo Fu; Shao-Yuan Cui; Yuan Zu; Ling-Jun Rong; Fan Hu; Xiang-Mei Chen; Yan-Ping Gong; Chun-Lin Li (Cell Biochemistry and Biophysics, 2022)

Evaluation of Reprocessed Fengyun-3B Global Outgoing Longwave Radiation Data: Comparison with CERES OLR - Wanchun Zhang; Jian Liu; Peng Zhang; Ling Sun; Hanlie Xu; Yanjiao Wang; Lin Chen (Journal of Meteorological Research, 2022)

Exploiting Sentinel-1 data and machine learning–based random forest for collectively mapping rice fields in Taiwan - Nguyen-Thanh Son; Chi-Farn Chen; Cheng-Ru Chen; Youg-Sin Cheng; Piero Toscano; Chein-Hui Syu; Horng-Yuh Guo; Shu-Ling Chen; Tsang-Sen Liu; Yi-Ting Zhang; Huan-Sheng Lin; Shih-Hsiang Chen; et al. (Applied Geomatics, 2022)

Functional differentiation and complementation of alkaline phosphatases and choreography of DOP scavenging in a marine diatom - Kaidian Zhang; Jiashun Li; Jierui Wang; Xin Lin; Ling Li; Yanchun You; Xiaomei Wu; Zhi Zhou; Senjie Lin (Molecular Ecology, 2022)
Facing phosphate deficiency, phytoplankton use alkaline phosphatase (AP) to scavenge dissolved organophosphate (DOP). AP is a multitype (e.g., PhoA, PhoD) family of hydrolases and is known as a promiscuous enzyme with broad DOP substrate compatibility. Yet, whether the multiple types differentiate on substrates and collaborate to provide physiological flexibility remain elusive. Here we identify PhoA and PhoDs and document the functional differentiation between PhoA and a PhoD (PhoD_45757) in Phaeodactylum tricornutum . CRISPR/Cas9‐based mutations and physiological analyses reveal that (1) PhoA is a secreted enzyme and contributes the majority of total AP activity whereas PhoD_45757 is intracellular and contributes a minor fraction of the total AP activity, (2) AP gene expression compensates for each other after one is disrupted, (3) the DOP→PhoA→phosphate_uptake and the DOP_uptake→PhoD→phosphate pathways function interchangeably for some DOP substrates. These findings shed light on the underpinning of AP’s multiformity and have important implications in phytoplankton phosphorus‐nutrient niche differentiation, physiological plasticity, and competitive strategy.

Optimization of aquaculture sustainability through ecological intensification in China - Shuang‐lin Dong; Yun‐wei Dong; Ling Cao; Johan Verreth; Yngvar Olsen; Wen‐jing Liu; Qi‐zhi Fang; Yan‐gen Zhou; Li Li; Jing‐yu Li; Yong‐tong Mu; Patrick Sorgeloos (Reviews in Aquaculture, 2022)
As the world's leading producer of farmed aquatic food products, China faces great uncertainty concerning the further sustainable development of its aquaculture industry due to high and increasing pressure from environmental and resource constraints. To realize truly sustainable development, it is imperative to establish an evaluation system that integrates social, economic, environmental and resource criteria, and optimizes aquaculture systems through a holistic approach. Here, we used analytical hierarchy processes combined with expert judgment and objective data to assess the sustainability of 10 major aquaculture production systems (APSs) in China. Based on the evaluation results, we propose the ecological intensification of aquaculture systems (ELIAS), rationally integrating anthropogenic inputs with aquaculture ecosystem services, to improve the sustainability of APSs. The holistic evaluation system and ELIAS are fundamental and critical for the future development of aquaculture in China and globally.

Cover Image, Volume 14, Issue 3 - Shuang‐lin Dong; Yun‐wei Dong; Ling Cao; Johan Verreth; Yngvar Olsen; Wen‐jing Liu; Qi‐zhi Fang; Yan‐gen Zhou; Li Li; Jing‐yu Li; Yong‐tong Mu; Patrick Sorgeloos (Reviews in Aquaculture, 2022)
The cover image is based on the Review Article Optimization of aquaculture sustainability through ecological intensification in China by Shuang‐lin Dong et al., https://doi.org/10.1111/raq.12648 image

First report of chilli veinal mottle virus infecting tobacco in Guizhou, China - Yue Chen; Ting Ting Li; Jing Zhong; Li Ling Zhao; Ya Li Guo; Ye Chun Lin; Gui Gao; Yi Cao; Ming Ding (Journal of Plant Pathology, 2022)

P-Limitation Promotes Carbon Accumulation and Sinking of Emiliania huxleyi Through Transcriptomic Reprogramming - Cong Wang; Jingtian Wang; Ling Li; Yujie Wang; Senjie Lin (Frontiers in Marine Science, 2022)
Global warming is expected to cause decreases in nutrient availability, photosynthesis, and potentially carbon export in the ocean. But how, and by what molecular mechanisms, nutrient limitation affects biological pump (BP) efficiency of phytoplankton are poorly understood. Here, using transcriptomics, miRNAomics, and physiological measurements, we report that phosphorus (P)-limitation increased cellular carbon and calcium contents and sinking rate of the cosmopolitan phytoplankton Emiliania huxleyi . Under P-limitation, when photosynthesis was depressed, there were substantial increases in cellular organic (3.4-fold) and inorganic (fivefold) carbon contents due to cell division arrest and, as our transcriptomic data suggest, CO 2 incorporation into C4 compounds. Furthermore, calcification was increased by 46% through transcriptional and epigenetic regulations. An increase in sinking rate by 37-44% was detected. Although calcification releases equivalent amounts of CO 2 , the considerable increase in cellular carbon content and sinking rate far outweighed the CO 2 release, leading to an elevated efficiency of carbon export by E. huxleyi , which would partially offset the decrease in BP capacity resulting from lower growth rate under P deficiency. However, how the observed sinking rate and its increase under P limitation on the laboratory cultures will translate into BP efficiency still requires further examination using in situ or mesocosm experiments.

Income inequality, educational attainment and environmental degradation: evidence from global panel - Suet-Ling Ching; Lin-Sea Lau; Chee-Keong Choong (Environmental Science and Pollution Research, 2022)

Metabolic tuning of a stable microbial community in the surface oligotrophic Indian Ocean revealed by integrated meta-omics - Zhang-Xian Xie; Ke-Qiang Yan; Ling-Fen Kong; Ying-Bao Gai; Tao Jin; Yan-Bin He; Ya-Yu Wang; Feng Chen; Lin Lin; Zhi-Long Lin; Hong-Kai Xu; Zong-Ze Shao; et al. (Marine Life Science & Technology, 2022)
Understanding the mechanisms, structuring microbial communities in oligotrophic ocean surface waters remains a major ecological endeavor. Functional redundancy and metabolic tuning are two mechanisms that have been proposed to shape microbial response to environmental forcing. However, little is known about their roles in the oligotrophic surface ocean due to less integrative characterization of community taxonomy and function. Here, we applied an integrated meta-omics-based approach, from genes to proteins, to investigate the microbial community of the oligotrophic northern Indian Ocean. Insignificant spatial variabilities of both genomic and proteomic compositions indicated a stable microbial community that was dominated by Prochlorococcus , Synechococcus , and SAR11. However, fine tuning of some metabolic functions that are mainly driven by salinity and temperature was observed. Intriguingly, a tuning divergence occurred between metabolic potential and activity in response to different environmental perturbations. Our results indicate that metabolic tuning is an important mechanism for sustaining the stability of microbial communities in oligotrophic oceans. In addition, integrated meta-omics provides a powerful tool to comprehensively understand microbial behavior and function in the ocean.

Responses of photosynthesis, antioxidant enzymes, and related gene expression to nicosulfuron stress in sweet maize (Zea mays L.) - Zhen-Xing Wu; Ning-Wei Xu; Min Yang; Xiang-Ling Li; Jin-Ling Han; Xiao-Hu Lin; Qing Yang; Gui-Hua Lv; Jian Wang (Environmental Science and Pollution Research, 2022)

Deformation characteristics and thresholds of the Tanjiawan landslide in the Three Gorges Reservoir Area, China - Fu-ling Zhang; Mao-lin Deng; Qing-lin Yi; Shu-qiang Lu; Wei-jun Zheng; Hai-feng Huang; Xing Zhu (Journal of Mountain Science, 2022)

Identification and expression profiling of HSP20 genes in Neoporphyra haitanensis - Ling-Na Peng; Lin-Bin Huang; Tian-Yu Gui; Da-Hai Gao; Xing-Hong Yan (Journal of Applied Phycology, 2022)

Genetic diversity and population structure of Curcuma alismatifolia Gagnep. accessions revealed by SSR markers - Hui-Wen Yu; Ling-Jun Ke; Yi-Lan Xiao; Si-Jia Chen; Yuan-Yuan Li; Qi-Lin Tian; Yun-He Li; Jin-Shui Lin; Luan-Mei Lu (Genetic Resources and Crop Evolution, 2022)

Effect of jet airflow deflection on cleaning performance of filter cartridge - Ling Ren; Na Yuan; Longyuan Lin; Chunhong He; Cuiying Tang; Zhiyong Xu (Environmental Science and Pollution Research, 2022)

Atmospheric deposition fluxes and health risk assessment of potentially toxic elements in Caohai Lake (Guizhou Province, China) - Shao-xia Lin; Zhuan-ling Zhang; Zhi-qiang Xiao; Xiao-lan Liu; Qing-hai Zhang (Journal of Mountain Science, 2022)

Preparation and In Vitro and In Vivo Evaluation of a Testosterone Film Forming Gel for the Treatment of Hypoactive Sexual Desire Disorder in Women - Jia Zeng; Tan-Fang Xie; Ting Huang; Fang Li; Zhi-Ping Wang; Ling-Lin Feng (AAPS PharmSciTech, 2022)

Anti-inflammatory constituents from Phyllostachys makinoi Hayata - Chia-Ching Liaw; Yu-Chi Lin; Shao-Yu Wu; Jenny Chun-Ling Kuo; Zhi-Hu Lin; Kai-Wei Lin; Huang Hui-Chi; Li-Ming Yang Kuo; Yao-Haur Kuo (Natural Product Research, 2022)

Nitrate runoff loss and source apportionment in a typical subtropical agricultural watershed - Yue Dong; Jin-Ling Yang; Xiao-Rui Zhao; Shun-Hua Yang; Jan Mulder; Peter Dörsch; Gan-Lin Zhang (Environmental Science and Pollution Research, 2022)

Description of Aureibaculum luteum sp. nov. and Aureibaculum flavum sp. nov. isolated from Antarctic intertidal sediments - Xiao-yan He; Ning-hua Liu; Chao-yi Lin; Mei-ling Sun; Xiu-lan Chen; Yu-zhong Zhang; Yu-qiang Zhang; Xi-ying Zhang (Antonie van Leeuwenhoek, 2022)

Bacterial Communities in Coral Offspring Vary Between in situ and ex situ Spawning Environments - Jia-Ho Shiu; Che-Hung Lin; Aziz Jabir Mulla; Viet Do Hung Dang; Chia-Ling Fong; Yoko Nozawa (Frontiers in Marine Science, 2022)
Examining the bacterial communities of offspring is key to understanding the establishment of coral-bacteria associations. Although high sensitivity to the environment is expected, previous studies have only examined bacterial communities of coral offspring in ex situ (laboratory) environments, not in in situ (field) environments. Here, we examined and compared the effect of ex situ and in situ environments on bacterial communities of newly released offspring (eggs and larvae) and their maternal colonies in two phylogenetically distant coral species with different reproductive modes: Dipsastraea speciosa (Scleractinia; spawner) and Heliopora coerulea (Octocorallia; brooder). Our results demonstrated that the spawning environments do not affect the bacterial composition in maternal colonies, but influence that of the offspring (eggs of D. speciosa and larvae of H. coerulea ). Dominant bacterial operational taxonomic units (OTUs) varied between in situ and ex situ environments in the eggs of D. speciosa . The composition of bacterial communities among larvae of H. coerulea samples was more diverse in in situ environments than in ex situ environments. This study provides the first information on in situ bacterial communities in coral eggs and larvae and highlights their sensitivities to the local environment. Future studies must take into consideration the influence of ex situ environments on bacterial communities in coral offspring.

Structure related α-glucosidase inhibitory activity and molecular docking analyses of phenolic compounds from Paeonia suffruticosa - Po-Chun Chen; Bongani Sicelo Dlamini; Chiy-Rong Chen; Yueh-Hsiung Kuo; Wen-Ling Shih; Yun-Sheng Lin; Chien-Hsing Lee; Chi-I Chang (Medicinal Chemistry Research, 2022)

Common Subtype of Small Renal Mass MR Imaging Characterisation: A Medical Center Experience in Taiwan - Ming-Cheng Liu; Yi-Jui Liu; Yen-Ting Lin; Siu-Wan Hung; Jyh-Wen Chai; Si-Wa Chan; Kun-Yuan Chiu; Ya-Ling Tsou (Journal of Medical and Biological Engineering, 2022)
Purpose Many studies have shown that multiparametric magnetic resonance imaging (MRI) may be helpful for differentiating malignant renal cell carcinomas (RCCs) from benign lesions. However, the key imaging characteristics that differ between malignant and benign tumors still require further discussion. Methods We analyzed 60 adult patients diagnosed with 72 small renal masses (SRMs) who received preoperative MRI from 2014 to 2019 at a hospital in Taiwan. The MRI features included conventional MRI parameters, diffusion-weighted imaging (DWI) data, and dynamic contrast-enhanced (DCE) patterns, which were documented and compared among the four common subtypes: clear cell RCC (ccRCC), papillary RCC (pRCC), angiomyolipoma (AML) and other types of RCC. The apparent diffusion coefficient (ADC) values of high- and low-grade RCCs were also analyzed. Results The results show that ccRCC had higher T2-weighted signal intensity than the other three subgroups, a higher arterial wash-in index (AWI) and ADC value than AML and pRCC, and manifested a plateau ( n = 9, 25%) or washout (n = 27, 75%) enhancement pattern. AMLs exhibited more intravoxel fat than the other three subtype groups, and half of the AMLs (6 in 12) contained bulk fat. pRCC demonstrated a more progressive (n = 3, 60%) enhancement pattern than the other three subgroups. The ADC value of high-grade RCCs was significantly lower than that of low-grade RCCs. Conclusion These findings may indicate that multiparametric MRI is useful in differentiating among four common pathological types of SRMs, and the ADC value may be helpful in evaluating the histological grade of malignancy.

Species richness and generalists–specialists mosaicism of symbiodiniacean symbionts in corals from Hong Kong revealed by high-throughput ITS sequencing - Osama S. Saad; Xin Lin; Tsz Yan Ng; Ling Li; Put Ang; Senjie Lin (Coral Reefs, 2022)

The lining responses for shallow mountain tunnels subjected to frost heaving - Xian-zhang Ling; Yuan Yu; Liang Tang; Lin Geng; Xiao Han (Journal of Mountain Science, 2022)

Identifying the priority areas for enhancing the ecosystem services in hilly and mountainous areas of southern China - Jia-ling Tian; Yu Peng; Yi-hang Huang; Ting Bai; Lian-lin Liu; Xiao-ao He; Shi-qian Luo (Journal of Mountain Science, 2022)

A new abietane-type diterpenoid and a new long-chain alkenone from fungus Daldinia sp. TJ403-LS1 - Shuang Lin; Xueke Zhang; Ling Shen; Shuyuan Mo; Junjun Liu; Jianping Wang; Zhengxi Hu; Yonghui Zhang (Natural Product Research, 2022)

New paraconic acids from the endophytic fungus Xylariaceae sp. J4 - Chao Yuan; Xue-Chun Shu; Lin Fan; Ying-Bo Zhang; Ling-Liang Guan; Fu-Lai Yu; Xiao-Lu Chen; Gang Li (Natural Product Research, 2022)

β-Catenin Deletion in Regional Neural Progenitors Leads to Congenital Hydrocephalus in Mice - Lin Ma; Yanhua Du; Xiangjie Xu; Hexi Feng; Yi Hui; Nan Li; Guanyu Jiang; Xiaoqing Zhang; Xiaocui Li; Ling Liu (Neuroscience Bulletin, 2022)

Technical methodologies for the assessment of the impacts of reclamation projects on marine ecology - Yurong Ouyang; Lin Wu; Juanjuan Dai; Yaojian Wu; Ling Cai; Qingsheng Li; Jianwei Wu; Shang Jiang (Environmental Science and Pollution Research, 2022)

FY-3E: The First Operational Meteorological Satellite Mission in an Early Morning Orbit - Peng Zhang; Xiuqing Hu; Qifeng Lu; Aijun Zhu; Manyun Lin; Ling Sun; Lin Chen; Na Xu (Advances in Atmospheric Sciences, 2022)

The Key Regulator of Necroptosis, RIP1 Kinase, Contributes to the Formation of Astrogliosis and Glial Scar in Ischemic Stroke - Yong-Ming Zhu; Liang Lin; Chao Wei; Yi Guo; Yuan Qin; Zhong-Sheng Li; Thomas A. Kent; Claire E. McCoy; Zhan-Xiang Wang; Yong Ni; Xian-Yong Zhou; Hui-Ling Zhang (Translational Stroke Research, 2021)
Necroptosis initiation relies on the receptor-interacting protein 1 kinase (RIP1K). We recently reported that genetic and pharmacological inhibition of RIP1K produces protection against ischemic stroke-induced astrocytic injury. However, the role of RIP1K in ischemic stroke-induced formation of astrogliosis and glial scar remains unknown. Here, in a transient middle cerebral artery occlusion (tMCAO) rat model and an oxygen and glucose deprivation and reoxygenation (OGD/Re)-induced astrocytic injury model, we show that RIP1K was significantly elevated in the reactive astrocytes. Knockdown of RIP1K or delayed administration of RIP1K inhibitor Nec-1 down-regulated the glial scar markers, improved ischemic stroke-induced necrotic morphology and neurologic deficits, and reduced the volume of brain atrophy. Moreover, knockdown of RIP1K attenuated astrocytic cell death and proliferation and promoted neuronal axonal generation in a neuron and astrocyte co-culture system. Both vascular endothelial growth factor D (VEGF-D) and its receptor VEGFR-3 were elevated in the reactive astrocytes; simultaneously, VEGF-D was increased in the medium of astrocytes exposed to OGD/Re. Knockdown of RIP1K down-regulated VEGF-D gene and protein levels in the reactive astrocytes. Treatment with 400 ng/ml recombinant VEGF-D induced the formation of glial scar; conversely, the inhibitor of VEGFR-3 suppressed OGD/Re-induced glial scar formation. RIP3K and MLKL may be involved in glial scar formation. Taken together, these results suggest that RIP1K participates in the formation of astrogliosis and glial scar via impairment of normal astrocyte responses and enhancing the astrocytic VEGF-D/VEGFR-3 signaling pathways. Inhibition of RIP1K promotes the brain functional recovery partially via suppressing the formation of astrogliosis and glial scar. Graphical Abstract

Is food production vulnerable to environmental degradation? A global analysis - Suet-Ling Ching; Kwang-Jing Yii; Cheong-Fatt Ng; Chee-Keong Choong; Lin-Sea Lau (Environmental and Ecological Statistics, 2021)

Phenolic glycosides and flavonoids with antioxidant and anticancer activities from Desmodium caudatum - Qian-Nan Xu; Dan Zhu; Guang-Hui Wang; Ting Lin; Cui-Ling Sun; Rong Ding; Wen-Jing Tian; Hai-Feng Chen (Natural Product Research, 2021)

Linking circular intronic RNA degradation and function in transcription by RNase H1 - Xiang Li; Jia-Lin Zhang; Yun-Ni Lei; Xiao-Qi Liu; Wei Xue; Yang Zhang; Fan Nan; Xiang Gao; Jun Zhang; Jia Wei; Li Yang; Ling-Ling Chen (Science China Life Sciences, 2021)

The diversity of alkane-degrading bacterial communities in seagrass ecosystem of the South China Sea - Ying Zhang; Qingsong Yang; Juan Ling; Yanying Zhang; Weiguo Zhou; Manzoor Ahmad; Xiangcheng Lin; Liyun Lin; Qiuying Peng; Junde Dong (Ecotoxicology, 2021)

The distribution characteristics of β-propeller phytase genes in rhizosphere sediment provide insight into species specialty from phytic mineralization in subtropical and tropical seagrass ecosystems - Liyun Lin; Juan Ling; Qiuying Peng; Xiancheng Lin; Weiguo Zhou; Yanying Zhang; Qingsong Yang; Manzoor Ahamad; Ying Zhang; Cong Wang; Youshao Wang; Junde Dong (Ecotoxicology, 2021)

Diversity and abundance of diazotrophic communities of seagrass Halophila ovalis based on genomic and transcript level in Daya Bay, South China Sea - Weiguo Zhou; Dewen Ding; Qingsong Yang; Juan Ling; Manzoor Ahmad; Xiancheng Lin; Liyun Lin; Ying Zhang; Junde Dong (Archives of Microbiology, 2021)

Two new cephalochromin derivative from the Alternaria sp. ZG22 - Xin-Ming Song; Xue-Ming Zhou; Ya-Ling Li; Li-Bing Huang; Cai-Cui Chen; Yan Gao; Lin He; Xiao-qun Mao; Bing Chen; Jing-Wen Liu; Hui-Jie Liu; Xiao-Ping Song; et al. (Natural Product Research, 2021)

Dynamic Regulation of Ions and Amino Acids in Adult Asian Hard Clams Meretrix lusoria Upon Hyperosmotic Salinity - Chia-Hao Lin; Po-Ling Yeh; Yu-Chun Wang; Tsung-Han Lee (Frontiers in Marine Science, 2021)
The dynamic regulation of ions and amino acids in the gills and mantle of the Asian hard clam, Meretrix lusoria , following the exposure to a hyperosmotic environment was hitherto unclear. The present study revealed that the osmolality as well as the Na + and Cl – concentrations in the hemolymph were significantly increased 3 h after transferring the clams from an environment with the salinity of their natural habitat (brackish water; BW; 20‰) to one with hyperosmotic salinity (seawater; 35‰). In addition, we found that the specific activities of Na + /K + -ATPase, a key enzyme that plays a significant role in cell osmoregulation, in the gills and mantle of clams were significantly increased at 72 and 12 h post-transfer, respectively, during acclimation to hyperosmotic salinity. Similarly, the contents of free amino acids (FAAs) such as taurine, alanine, and glycine were significantly elevated during hyperosmotic salinity acclimation. Previous research indicates that taurine is the most abundant FAA in the gills and mantles of Asian hard clams and that the taurine transporter (TAUT) plays an important role in taurine accumulation. The present study showed that TAUT mRNA and protein expression were significantly and transiently increased in the mantle of Asian hard clams following exposure to seawater; although the expression of TAUT mRNA in the gills of Asian hard clams was also transiently stimulated by exposure to hyperosmotic salinity, the relative TAUT protein abundance decreased only at later stages. Accordingly, the findings of this study improve our understanding of the dynamic processes of ion and amino acid regulation in the peripheral tissues of bivalves under hyperosmotic stress.

Three new species of Cylindrobasidium (Physalacriaceae, Agaricales) from East Asia - Yi-Chung Lin; Chia-Ling Wei; Chi-Yu Chen; Che-Chih Chen; Sheng-Hua Wu (Mycological Progress, 2021)

Carbon transfer from the submerged macrophyte Hydrilla verticillata to zooplankton: a 13C-labeled mesocosm study - Ling Su; Zongan Jin; Lichao Xie; Yali Tang; Zhengwen Liu; Ping Zhong; Yaling Su; Qiuqi Lin (Hydrobiologia, 2021)

Degraded polysaccharides from Porphyra haitanensis: purification, physico-chemical properties, antioxidant and immunomodulatory activities - Yun-Feng Huo; Yin-Ting Li; Wei Xia; Chong Wang; Yuan-Yuan Xie; Yan-Bo Wang; Tao Zhou; Ling-Lin Fu (Glycoconjugate Journal, 2021)

Quercetin Attenuates High-Fat Diet-Induced Excessive Fat Deposition of Spotted Seabass (Lateolabrax maculatus) Through the Regulatory for Mitochondria and Endoplasmic Reticulum - Yan-Zou Dong; Tian Xia; Ji-Bin Lin; Ling Wang; Kai Song; Chun-Xiao Zhang (Frontiers in Marine Science, 2021)
This study aimed to investigate the effects of quercetin (QUE) on fat deposition and the underlying mechanism. Fish were fed four test diets: normal fat diet (NFD), high-fat diet (HFD), and HFD supplemented with 0.5 or 1.0 g/kg quercetin (QUE0.5 or QUE1.0). The results showed that HFD feeding resulted in poor growth and feed utilization while QUE treatment reversed this. The fat contents of serum and liver were increased by HFD and QUE supplementation significantly decreased fat content. Furthermore, gene expressions and ultrastructure observation showed that mitochondrial biogenesis and mitophagy were inhibited and endoplasmic reticulum stress (ERS) in the HFD group. QUE can activate the biogenesis and autophagy of mitochondria and suppress ERS, which is related to its fat-lowering effect.

Efficiently immobilizing uranium (VI) by oxidized carbon foam - Hongliang Bao; Chunyu Xie; Ling Han; Zenghui Yue; Yuan Qian; Linjuan Zhang; Zi-Jian Li; Huangjie Lu; Jian Lin; Jian-Qiang Wang (Environmental Science and Pollution Research, 2021)

Long-term effects of liquid swine manure land surface application in an apple orchard field on soil bacterial community and heavy metal contents in apple (Malus pumila Mill.) - Hongchao Jiao; Qin Yin; Cunhu Fan; Ling Wang; Jingpeng Zhao; Xiaojuan Wang; Kun Du; Hai Lin (Environmental Science and Pollution Research, 2021)

Dating deformation using sheared leucogranite: temporal constraints by 40Ar/39Ar thermochronology for the Mae Ping shear zone, NW Thailand - Yu-Ling Lin; Tung-Yi Lee; Ching-Hua Lo; Sarah C. Sherlock; Yoshiyuki Iizuka; Tadashi Usuki; Long Xiang Quek; Punya Charusiri (Contributions to Mineralogy and Petrology, 2021)

Cortisol and glucocorticoid receptor 2 regulate acid secretion in medaka (Oryzias latipes) larvae - Chia-Hao Lin; Huei-Jyun Hu; Hsin-Ju Chuang; Yi-Ling Tsou; Pung-Pung Hwang (Journal of Comparative Physiology B, 2021)

The relationship between anthocyanin accumulation and photoprotection in young leaves of two dominant tree species in subtropical forests in different seasons - Zheng-Chao Yu; Wei Lin; Xiao-Ting Zheng; Wah Soon Chow; Yan-Na Luo; Min-Ling Cai; Chang-Lian Peng (Photosynthesis Research, 2021)

The major photoprotective role of anthocyanins in leaves of Arabidopsis thaliana under long-term high light treatment: antioxidant or light attenuator? - Xiao-Ting Zheng; Zheng-Chao Yu; Jun-Wei Tang; Min-Ling Cai; Yi-Lin Chen; Cheng-Wei Yang; Wah Soon Chow; Chang-Lian Peng (Photosynthesis Research, 2021)

Photosynthetic compensation of non-leaf organ stems of the invasive species Sphagneticola trilobata (L.) Pruski at low temperature - Min-ling Cai; Wen-qiao Ding; Jun-jie Zhai; Xiao-ting Zheng; Zheng-chao Yu; Qi-lei Zhang; Xiao-hua Lin; Wah Soon Chow; Chang-lian Peng (Photosynthesis Research, 2021)

Associations of Sleep Characteristics with Cerebrospinal Fluid sTREM2 in Cognitively Normal Older Adults: the CABLE Study - He-Ying Hu; Ling-Zhi Ma; Hao Hu; Yan-Lin Bi; Ya-Hui Ma; Xue-Ning Shen; Ya-Nan Ou; Qiang Dong; Lan Tan; Jin-Tai Yu (Neurotoxicity Research, 2021)

Characteristics of bacterial community and ARGs profile in engineered goldfish tanks with stresses of sulfanilamide and copper - Benjamin Makimilua Tiimub; Zhen-chao Zhou; Lin Zhu; Yang Liu; Xin-Yi Shuai; Lan Xu; Christophe’ Niyungeko; Ling-Xuan Meng; Yu-Jie Sun; Hong Chen (Environmental Science and Pollution Research, 2021)

Effect of PAHs on nitrogen-fixing and sulfate-reducing microbial communities in seagrass Enhalus acoroides sediment - Juan Ling; Weiguo Zhou; Qingsong Yang; Xiancheng Lin; Ying Zhang; Manzoor Ahmad; Qinying Peng; Junde Dong (Archives of Microbiology, 2021)

Water Vapor Retrievals from Near-infrared Channels of the Advanced Medium Resolution Spectral Imager Instrument onboard the Fengyun-3D Satellite - Ling Wang; Xiuqing Hu; Na Xu; Lin Chen (Advances in Atmospheric Sciences, 2021)

A new ent -kaurane diterpene from Isodon henryi - Xue Jiang; Ling-Xia Zhang; Qing-Mei Feng; Hong Wu; Ya-Lin Liu; De-Qin Wang; Li-Ping Dai; Zhi-Min Wang (Natural Product Research, 2021)

Trichome Lengths of the Heterocystous N2-Fixing Cyanobacteria in the Tropical Marginal Seas of the Western North Pacific - Sing-how Tuo; Margaret R. Mulholland; Yukiko Taniuchi; Houng-Yung Chen; Wann-Neng Jane; Yen-Huei Lin; Yuh-ling Lee Chen (Frontiers in Marine Science, 2021)
Calothrix rhizosoleniae and Richelia intracellularis are heterocystous cyanobacteria found in the tropical oceans. C. rhizosoleniae commonly live epiphytically on diatom genera Chaetoceros ( C-C ) and Bacteriastrum ( B-C ) while R. intracellularis live endosymbiotically within Rhizosolenia ( R-R ), Guinardia ( G-R ), and Hemiaulus ( H-R ); although, they occasionally live freely (FL- C and FL- R ). Both species have much shorter trichomes than the other marine filamentous cyanobacteria such as Trichodesmium spp. and Anabaena gerdii . We investigated the trichome lengths of C. rhizosoleniae and R. intracellularis in the South China Sea (SCS) and the Philippine Sea (PS) between 2006 and 2014. On average, H-R had the shortest trichome lengths (3.5 cells/trichome), followed by B-C and C-C (4.9–5.2 cells/trichome) and FL- C (5.9 cells/trichome), and R-R , G-R , and FL- R had the longest trichome lengths (7.4–8.3 cells/trichome). Field results showed the trichome lengths of C-C and B-C did not vary seasonally or regionally. However, FL- C and H-R from the SCS and during the cool season had longer trichomes, where/when the ambient nutrient concentrations were higher. R-R , G-R , and FL- R also showed regional and seasonal variations in trichome length. Ultrastructural analysis found no gas vesicles within the C. rhizosoleniae cells to assist in buoyancy regulation. Results suggest that the trichome lengths of C. rhizosoleniae and R. intracellularis might be regulated by their diatom hosts’ symbiotic styles and by ambient nutrients. Short trichome length might help C. rhizosoleniae and R. intracellularis to stay in the euphotic zone regardless as to whether they are free-living or symbiotic.

Identification of a delayed leaf greening gene from a mutation of pummelo - Hui-Wen Yu; Zhi-Hao Lu; Xia Wang; Dan Liu; Jia-Xian He; Xiao-Lin Jiang; Ling-Jun Ke; Wen-Wu Guo; Xiu-Xin Deng; Qiang Xu (Science China Life Sciences, 2021)

Identification of three seagrass species in coral reef ecosystem by using multiple genes of DNA barcoding - Xiancheng Lin; Junde Dong; Qingsong Yang; Weiguo Zhou; Yan Wang; Ying Zhang; Manzoor Ahmad; Yingting Sun; Youshao Wang; Juan Ling (Ecotoxicology, 2021)

Vibrio nitrifigilis sp. nov., a marine nitrogen-fixing bacterium isolated from the lagoon sediment of an islet inside an atoll - Wei-Sheng Huang; Li-Ting Wang; Jwo-Sheng Chen; Yen-Ting Chen; Sean Ting-Shyang Wei; Yin-Ru Chiang; Pei-Ling Wang; Tzong-Huei Lee; Shih-Ting Lin; Lina Huang; Wung Yang Shieh (Antonie van Leeuwenhoek, 2021)

Detection of Vestibular Schwannoma on Triple-parametric Magnetic Resonance Images Using Convolutional Neural Networks - Tzu-Hsuan Huang; Wei-Kai Lee; Chih-Chun Wu; Cheng-Chia Lee; Chia-Feng Lu; Huai-Che Yang; Chun-Yi Lin; Wen-Yuh Chung; Po-Shan Wang; Yen-Ling Chen; Hsiu-Mei Wu; Wan-You Guo; et al. (Journal of Medical and Biological Engineering, 2021)
Purpose The first step in typical treatment of vestibular schwannoma (VS) is to localize the tumor region, which is time-consuming and subjective because it relies on repeatedly reviewing different parametric magnetic resonance (MR) images. A reliable, automatic VS detection method can streamline the process. Methods A convolutional neural network architecture, namely YOLO-v2 with a residual network as a backbone, was used to detect VS tumors from MR images. To heighten performance, T1-weighted–contrast-enhanced, T2-weighted, and T1-weighted images were combined into triple-channel images for feature learning. The triple-channel images were cropped into three sizes to serve as input images of YOLO-v2. The VS detection effectiveness levels were evaluated for two backbone residual networks that downsampled the inputs by 16 and 32. Results The results demonstrated the VS detection capability of YOLO-v2 with a residual network as a backbone model. The average precision was 0.7953 for a model with 416 × 416-pixel input images and 16 instances of downsampling, when both the thresholds of confidence score and intersection-over-union were set to 0.5. In addition, under an appropriate threshold of confidence score, a high average precision, namely 0.8171, was attained by using a model with 448 × 448-pixel input images and 16 instances of downsampling. Conclusion We demonstrated successful VS tumor detection by using a YOLO-v2 with a residual network as a backbone model on resized triple-parametric MR images. The results indicated the influence of image size, downsampling strategy, and confidence score threshold on VS tumor detection.

Planning for climate change: evaluating the changing patterns of flood vulnerability in a case study in New Taipei City, Taiwan - Tzu-Ling Chen; Zih-Hong Lin (Stochastic Environmental Research and Risk Assessment, 2021)

LncRNA RNCR3 promotes endothelial cell proliferation and inflammatory cytokine secretion via regulating miR-185-5p/cyclin D2 axis - Quanlong Hong; Lin Ling; Wenli Huang; Yilan Liu; Yafen Zhuo; Zhenzhen Hong; Bing Wu; Yi Zhang (Environmental Science and Pollution Research, 2021)

PI3K/Akt/mTOR Signaling as Targets for Developing Anticancer Agents from Marine Organisms - Mingyue Guo; Ling Zuo; Gan Qiao; Minghua Liu; Shousong Cao; Xiukun Lin (Journal of Ocean University of China, 2021)

Cytotoxic p -terphenyls from the deep-sea-derived Aspergillus candidus - Yu-Kun Lin; Chun-Lan Xie; Cui-Ping Xing; Bao-Qu Wang; Xiao-Xue Tian; Jin-Mei Xia; Ling-Yun Jia; Ying-Ni Pan; Xian-Wen Yang (Natural Product Research, 2021)

Identification of two UDP-glycosyltransferases involved in the main oleanane-type ginsenosides in Panax japonicus var. major - Jun-Rong Tang; Geng Chen; Ying-Chun Lu; Qing-Yan Tang; Wan-Ling Song; Yuan Lin; Ying Li; Su-Fang Peng; Sheng-Chao Yang; Guang-Hui Zhang; Bing Hao (Planta, 2021)

Stoichiometric relations of C, N, and P in urban top soils in Nanjing, China, and their biogeochemical implications - Jin-Ling Yang; Da-Gang Yuan; Yu-Guo Zhao; Yue He; Gan-Lin Zhang (Journal of Soils and Sediments, 2021)

Physical interactions facilitate sex change in the protogynous orange‐spotted grouper, Epinephelus coioides - Jiaxing Chen; Cheng Peng; Jingjun Huang; Herong Shi; Ling Xiao; Lin Tang; Haoran Lin; Shuisheng Li; Yong Zhang (Journal of Fish Biology, 2021)
Sex change in teleost fishes is commonly regulated by social factors. In species that exhibit protogynous sex change, such as the orange‐spotted grouper Epinephelus coioides , when the dominant males are removed from the social group, the most dominant female initiates sex change. The aim of this study was to determine the regulatory mechanisms of socially controlled sex change in E. coioides . We investigated the seasonal variation in social behaviours and sex change throughout the reproductive cycle of E. coioides , and defined the behaviour pattern of this fish during the establishment of a dominance hierarchy. The social behaviours and sex change in this fish were affected by season, and only occurred during the prebreeding season and breeding season. Therefore, a series of sensory isolation experiments was conducted during the breeding season to determine the role of physical, visual and olfactory cues in mediating socially controlled sex change. The results demonstrated that physical interactions between individuals in the social groups were crucial for the initiation and completion of sex change, whereas visual and olfactory cues alone were insufficient in stimulating sex change in dominant females. In addition, we propose that the steroid hormones 11‐ketotestosterone and cortisol are involved in regulating the initiation of socially controlled sex change.

Rosanortriterpenes A–B, two new nortriterpenes from the fruits of Rosa laevigata var. leiocapus - Yu-Nong Tian; Bai-Lin Li; Juan-Juan Hu; Jin-Dan Xie; Wen-Jing Xiao; Ling-Hui Nie; Jie-Wei Wu (Natural Product Research, 2021)

Activating Transcription Factor 6 Contributes to Functional Recovery After Spinal Cord Injury in Adult Zebrafish - Zhe Ji; Zhi-Lan Zhou; Qin Hao; Lin Zhao; Chun Cui; Shu-Bing Huang; Yan-Ling Yang; Yan-Qin Shen (Journal of Molecular Neuroscience, 2021)

Molecular cloning and functional characterization of the hypoxia-inducible factor-1α in bighead carp (Aristichthys nobilis) - Yan Lin; Ling-Hong Miao; Bo Liu; Bing-Wen Xi; Liang-Kun Pan; Xian-Ping Ge (Fish Physiology and Biochemistry, 2021)

Rhizosphere microbiome dynamics in tropical seagrass under short-term inorganic nitrogen fertilization - Weiguo Zhou; Junde Dong; Dewen Ding; Lijuan Long; Anning Suo; Xiancheng Lin; Qingsong Yang; Liyun Lin; Yanying Zhang; Juan Ling (Environmental Science and Pollution Research, 2021)

Increased depression risk for elderly women with high blood levels of strontium and barium - Jia Lv; Yan-ling Li; Wen-qiang Ren; Rong Li; Jian-rong Chen; Chao Bao; Zhi-ping Du; Shun Feng; Ling Gu; Hui Gao; Kai-yong Liu; Lin-sheng Yang; et al. (Environmental Chemistry Letters, 2021)

Atrial fibrillation rhythm is associated with marked changes in metabolic and myofibrillar protein expression in left atrial appendage - Julie H. Rennison; Ling Li; Cheryl R. Lin; Beth S. Lovano; Laurie Castel; Sojin Youn Wass; Catherine C. Cantlay; Meghan McHale; A. Marc Gillinov; Reena Mehra; Belinda B. Willard; Jonathan D. Smith; et al. (Pflügers Archiv - European Journal of Physiology, 2021)

CXCL10/CXCR3 Signaling in the DRG Exacerbates Neuropathic Pain in Mice - Yan-Fang Kong; Wei-Lin Sha; Xiao-Bo Wu; Lin-Xia Zhao; Ling-Jie Ma; Yong-Jing Gao (Neuroscience Bulletin, 2021)

The response to flooding of two overwintering rice stem borers likely accounts for their changing impacts - Guang-Hua Luo; Zhi-Xin Luo; Zhi-Ling Zhang; Yang Sun; Ming-Hong Lu; Zhao-Lin Shu; Zi-Hua Tian; Ary A. Hoffmann; Ji-Chao Fang (Journal of Pest Science, 2021)

Remediation of contaminated soil and groundwater using chemical reduction and solidification/stabilization method: a case study - Shi-Feng Lu; Yu-Lin Wu; Zhan Chen; Tao Li; Chao Shen; Lin-Kang Xuan; Ling Xu (Environmental Science and Pollution Research, 2021)

Identification of contaminants as members of the Bacillus pumilus group and analysis of contamination sources in the cultivation of Pleurotus geesteranus mushrooms - Na Lu; Wei-Dong Yuan; You-Liang Wu; Ji-Ling Song; Lin Ma; Wei-Ke Wang; Jing Yan; Zai-Ming Chen; Qing Chen (Journal of Plant Pathology, 2021)

Reliability and Validity of a Mobile Device for Assessing Head Control Ability - Mohammad Nikkhoo; Chi-Chien Niu; Chen-Ju Fu; Meng-Ling Lu; Wen-Chien Chen; Yang-Hua Lin; Chih-Hsiu Cheng (Journal of Medical and Biological Engineering, 2021)

Prevalence and outcomes of re-positive nucleic acid tests in discharged COVID-19 patients - Hou-wei Du; Jun-nian Chen; Xiao-bin Pan; Xiao-ling Chen; Yixian-Zhang; Shuang-fang Fang; Xiao-qing Li; Pin-cang Xia; Lei Gao; Hai-long Lin; Li-min Chen; Nan Liu (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Soil anti-scourability enhanced by herbaceous species roots in a reservoir water level fluctuation zone - Wen-xiu Xu; Ling Yang; Yu-hai Bao; Jin-lin Li; Jie Wei (Journal of Mountain Science, 2021)

Method for fast staining and obtaining high-magnification and high-resolution cell images of Nicotiana benthamiana - Yuanyuan Jiang; Jiangrong Peng; Yunpeng Cao; Zhiqiang Han; Ling Zhang; Wenbing Su; Shunquan Lin; Yuan Yuan; Bin Wang; Xianghui Yang; Zhike Zhang (Physiology and Molecular Biology of Plants, 2021)

Sea Urchins Play an Increasingly Important Role for Coral Resilience Across Reefs in Taiwan - Viet D. H. Dang; Pak-Yin Cheung; Chia-Ling Fong; Aziz J. Mulla; Jia-Ho Shiu; Che-Hung Lin; Yoko Nozawa (Frontiers in Marine Science, 2020)
Herbivores are an important functional group that control algae, create new space, and promote recruitment for coral recovery. However, on many coral reefs, overfishing has greatly decreased the density of herbivores, especially fishes and gastropods, impairing coral resilience. On such overfished reefs, remnant herbivores that are not target species of local fisheries, e.g., sea urchins, are expected to play an increasingly important role, yet few studies, except for those in the Caribbean and Kenya have examined non-fish herbivores in relation to coral resilience. Here, we conducted field surveys at 30 sites along three coral reefs in Taiwan between 2016 and 2017, to examine the relative importance of six key factors for coral resilience: herbivore abundance (fishes, gastropods, sea urchins), coral cover, macroalgal cover, habitat complexity, water depth, and wave exposure. The density of juvenile coral was used as a proxy of coral resilience. Diadematid sea urchins ( Echinothrix spp. and Diadema spp.) dominated most sites (19 of 30 sites) and multivariable regression models showed sea urchin density as the best positive predictor of coral juvenile density. The results elucidated the increasing role diadematid sea urchins play as remnant herbivores on overfished coral reefs in Taiwan. Given that overfishing is a widespread issue, this phenomenon may be occurring globally. More studies are needed to examine the role of remnant, but often ignored, sea urchin herbivory on coral resilience. Reef managers should consider monitoring locally remnant herbivores and incorporating them into management strategies.

Management of Gout-associated MSU crystals-induced NLRP3 inflammasome activation by procyanidin B2: targeting IL-1β and Cathepsin B in macrophages - Chun-Ying Qiao; Ying Li; Yue Shang; Min Jiang; Jian Liu; Zi-Ying Zhan; Huan Ye; Yong-Ce Lin; Jing-Ya Jiao; Rong-Hui Sun; Zhi-Hong Zhang; Mei-Hua Piao; et al. (Inflammopharmacology, 2020)

The extract of aquatic macrophyte Carex cinerascens induced colony formation in bloom-forming cyanobacterium Microcystis aeruginosa - Lin Li; Xiao-ling Jing; Ling Wang; Zhi-gao Zeng; Wen-hong Chen; Jia-hao Zhai; Si-qin Qi (Environmental Science and Pollution Research, 2020)

Overexpression of a multifunctional β-glucosidase gene from thermophilic archaeon Sulfolobus solfataricus in transgenic tobacco could facilitate glucose release and its use as a reporter - Chih-Hao Huang; Tzu-Ling Huang; Yu-Chang Liu; Ting-Chieh Chen; Shih-Ming Lin; Shyh-Yu Shaw; Ching-Chun Chang (Transgenic Research, 2020)

MAPK pathway‐related tyrosine phosphatases regulate development, secondary metabolism and pathogenicity in fungus Aspergillus flavus - Guang Yang; Xiaohong Cao; Genli Ma; Ling Qin; Yuanzhen Wu; Jian Lin; Peng Ye; Jun Yuan; Shihua Wang (Environmental Microbiology, 2020)
Summary Mitogen‐activated protein kinase (MAPK) cascades are highly conserved in eukaryotic cells and are known to play crucial roles in the regulation of various cellular processes. However, compared with kinase‐mediated phosphorylation, dephosphorylation catalysed by phosphatases has not been well characterized in filamentous fungi. In this study, we identified five MAPK pathway‐related phosphatases (Msg5, Yvh1, Ptp1, Ptp2 and Oca2) and characterized their functions in Aspergillus flavus , which produces aflatoxin B 1 (AFB 1 ), one of the most toxic and carcinogenic secondary metabolites. These five phosphatases were identified as negative regulators of MAPK (Slt2, Fus3 and Hog1) pathways. Deletion of Msg5 and Yvh1 resulted in significant defects in conidiation, sclerotia formation, aflatoxin production and crop infection. Additionally, double knockout mutants (Δ Msg5/ Δ Ptp1 , Δ Msg5/ Δ Ptp2 and Δ Msg5/ Δ Oca2 ) displayed similar defects to those observed in the Δ Msg5 single mutant, indicating that Msg5 plays a major role in the regulation of development and pathogenicity in A . flavus . Importantly, we found that the active site at C439 is essential for the function of the Msg5 phosphatase. Furthermore, the MAP kinase Fus3 was found to be involved in the regulation of development, aflatoxin biosynthesis and pathogenicity, and its conserved phosphorylation residues (Thr and Tyr) were critical for the full range of its functions in A . flavus . Overall, our results reveal that MAPK related tyrosine phosphatases play important roles in the regulation of development, secondary metabolism and pathogenicity in A . flavus , and could be developed as potential targets for preventing damage caused by this fungal pathogen.

Small grain and semi-dwarf 3, a WRKY transcription factor, negatively regulates plant height and grain size by stabilizing SLR1 expression in rice - Jie Lan; Qibing Lin; Chunlei Zhou; Yakun Ren; Xi Liu; Rong Miao; Ruonan Jing; Changling Mou; Thanhliem Nguyen; Xingjie Zhu; Qian Wang; Xin Zhang; et al. (Plant Molecular Biology, 2020)

Two new species of Hortiboletus (Boletaceae, Boletales) from China - Hui-Jing Xie; Wen-Fei Lin; Shuai Jiang; Rou Xue; Lu-Ling Wu; Yu-Zhuo Zhang; Zhi-Qun Liang; Nian-Kai Zeng; Ming-Sheng Su (Mycological Progress, 2020)

Machine learning approaches for rice crop yield predictions using time-series satellite data in Taiwan - Nguyen-Thanh Son; Chi-Farn Chen; Cheng-Ru Chen; Horng-Yuh Guo; Youg-Sing Cheng; Shu-Ling Chen; Huan-Sheng Lin; Shih-Hsiang Chen (International Journal of Remote Sensing, 2020)

Characterization of transcription activation domain of EcaICE1 and its interaction with EcaSIZ1 in Eucalyptus camaldulensis - Ziyang Zhang; Ling Cheng; Weihua Zhang; Jianlin Hu; Yan Liu; Yuanzhen Lin (Trees, 2020)

Cloning and Characterization of a Ginsenoside-Hydrolyzing α-L-Arabinofuranosidase, CaAraf51, From Cellulosimicrobium aquatile Lyp51 - Sha-Sha Zuo; Yu-Chen Wang; Ling Zhu; Jiang-Yuan Zhao; Ming-Gang Li; Xiu-Lin Han; Meng-Liang Wen (Current Microbiology, 2020)

2D slope stability analysis based on Pan’s maximum principle - Xiao Gang Wang; Xing Chao Lin; Ping Sun; Xu Li; Yu Jie Wang; Yong Yu Ling (Bulletin of Engineering Geology and the Environment, 2020)

Xanthatin mediates G 2 /M cell cycle arrest, autophagy and apoptosis via ROS/XIAP signaling in human colon cancer cells - Ya-di Geng; Lei Zhang; Guo-Yu Wang; Xiao-Jun Feng; Zhao-Lin Chen; Ling Jiang; Ai-Zong Shen (Natural Product Research, 2020)

RES transformation for biosynthesis and detoxification - Jin-Quan Huang; Jia-Ling Lin; Xiao-Xiang Guo; Xiu Tian; Ye Tian; Xiao-Xia Shangguan; Ling-Jian Wang; Xin Fang; Xiao-Ya Chen (Science China Life Sciences, 2020)

Rule-Based Object-Oriented Water Resource System Simulation Model for Water Allocation - Pengfei Lin; Jinjun You; Hong Gan; Ling Jia (Water Resources Management, 2020)
Simulation is a basic method to analyze water resources system and provide information for decision-making. In this study, a framework is presented that describes the basic elements in a water resource system and a modelling technique integrating conceptual simulation and rule control. To formulate the process of the water cycle and water exploitation with a mathematical model, the water system is described based on adjustable relevant rules and respective parameters with experiences and pragmatic demands in the framework. The rule set describes the principles required to design conceptual networks and control the concrete processes of movement and conversion of different water flows. Combined with object-oriented programming, different calculation functional modules are classified based on the characteristics of water source layers, and the processes that occur in the networks are realised in the computation. The influence of the South-to-North Water Diversion project on the Haihe River basin is analysed by the rule-based object-oriented water resource allocation simulation model. According to the simulation results, groundwater extraction will be reduced by 6,181 million m 3 . The relationship between water source replacement and water layer exchange in the Haihe River basin is analysed, and the feasibility of the model is verified. Based on the rule-based model, the user requirements can be taken into account conveniently, and the rules are flexible to adjust with experiences and real conditions. This model can be used to simulate complex water resource systems.

Four new species of Phylloporia (Hymenochaetales, Basidiomycota) from southeastern Taiwan - Sheng-Hua Wu; Chiung-Chih Chang; Chia-Ling Wei; Yu-Ting Lin; Siou-Zhen Chen (Mycological Progress, 2020)

RETRACTED ARTICLE: Paeoniflorin attenuates early brain injury through reducing oxidative stress and neuronal apoptosis after subarachnoid hemorrhage in rats - Tao Wang; Ling Xu; Lei Gao; Lin Zhao; Xin-hong Liu; Yan-yan Chang; Yun-lin Liu (Metabolic Brain Disease, 2020)

Cinnamaldehyde improves the growth performance and digestion and absorption capacity in grass carp (Ctenopharyngodon idella) - Yang Zhou; Wei-Dan Jiang; Jin-Xiu Zhang; Lin Feng; Pei Wu; Yang Liu; Jun Jiang; Sheng-Yao Kuang; Ling Tang; Yan Peng; Xiao-Qiu Zhou (Fish Physiology and Biochemistry, 2020)

The dynamic process of dietary soybean β-conglycinin in digestion, absorption, and metabolism among different intestinal segments in grass carp (Ctenopharyngodon idella) - Xu-Dong Duan; Lin Feng; Wei-Dan Jiang; Pei Wu; Yang Liu; Jun Jiang; Bei-Ping Tan; Qi-Hui Yang; Sheng-Yao Kuang; Ling Tang; Xiao-Qiu Zhou (Fish Physiology and Biochemistry, 2020)

Bone marrow mesenchymal stem cells combine with normothermic machine perfusion to improve rat donor liver quality—the important role of hepatic microcirculation in donation after circulatory death - Liu Yang; Huan Cao; Dong Sun; Bin Hou; Ling Lin; Zhong-Yang Shen; Hong-Li Song (Cell and Tissue Research, 2020)
Donation after circulatory death (DCD) can expand the donor pool effectively. A gap remains in outcome between DCD livers and living donor livers, warranting improved DCD liver quality and urgent resolution. Bone marrow mesenchymal stem cells (BMMSCs) can regulate immunity, participate in the anti-inflammatory response, and secrete cytokines. We investigated the effect of BMMSCs combined with normothermic machine perfusion (NMP) on DCD liver quality, and the role of microcirculation therein. Rat thoracic aortas were clipped to obtain DCD livers, and a rat NMP system was established. The DCD livers were grouped by preservation method: normal, static cold storage (SCS), NMP (P), and BMMSCs plus NMP (BP); storage time was up to 8 h. Liver function in outflow perfusate was detected by biochemical methods; liver tissue histopathology was observed by hematoxylin–eosin staining; hepatocyte ultrastructure was observed by transmission electron microscopy; hepatocyte apoptosis was detected by terminal deoxynucleotidyl transferase dUTP nick end labeling; liver microcirculation–related indicators were detected by immunofluorescence, immunohistochemistry, Western blotting, and enzyme-linked immunosorbent assay. Compared with SCS, P and BP significantly improved liver function and liver histological damage, reduced hepatocyte apoptosis, and repaired hepatocyte mitochondrial damage after 6 h in vitro. BP also significantly inhibited intrahepatic macrophage activation and intercellular adhesion, improved endothelial damage, and significantly improved endothelin 1–nitric oxide balance and microcirculation perfusion. In conclusion, BP can improve DCD liver microcirculation and quality. The mechanism may be the improvement of improve hepatic sinusoidal endothelial injury and microcirculation perfusion by inhibiting macrophage activation and intercellular adhesion.