Forecasting and analysis of the effect of lifestyle on cognitive dysfunction induced by occupational aluminum exposure based on Bayesian networks - Dan Zhao; Xiao Han; Jiaping Huan; Dan Gao; Tianshu Wang; Jing Song; Linping Wang; Huifang Zhang; Tiane Luo; Baolong Pan; Qiao Niu; Xiaoting Lu (Environmental Toxicology and Pharmacology, 2023)

Groundwater contaminant source identification based on an ensemble learning search framework associated with an auto xgboost surrogate - Zidong Pan; Wenxi Lu; Han Wang; Yukun Bai (Environmental Modelling & Software, 2023)

Single atom Co-anchored nitrogen‑doped graphene for peroxymonosulfate activation with high selectivity of singlet oxygen generation - Han-Qing Zhao; Jun-Sheng Song; Peili Lu; Yang Mu (Chemical Engineering Journal, 2023)

A long-life aqueous Zn battery enabled by simultaneous suppressing cathode dissolution and Zn dendrites via a novel water-in-deep eutectic solvent electrolyte - Wenfeng Wang; Ruyue Li; Zeang Duan; Jiajin Zhao; Yadi Qi; Qiubo Guo; Qiuming Peng; Desong Wang; Shumin Han; Lu Zhang (Chemical Engineering Journal, 2023)

Hierarchically porous zirconium-based metal–organic frameworks for rapid adsorption and enrichment of sulfonamide antibiotics - Lizhen Han; Peige Qin; Mengyuan Li; Dan Li; Mengyao Mu; Yanmei Gao; Shiping Zhu; Minghua Lu; Zongwei Cai (Chemical Engineering Journal, 2023)

Thermally insulating and electroactive cellular nanocellulose composite cryogels from hybrid nanofiber networks - Yi Hu; Meilian Cao; Jianing Xu; Xueying Liu; Jiqing Lu; Jie Yan; Siqi Huan; Guangping Han; Long Bai; Wanli Cheng; Orlando J. Rojas (Chemical Engineering Journal, 2023)

Two-Phase improves Bio-hydrogen and Bio-methane production of anaerobic membrane bioreactor from waste activated sludge with digestate recirculation - Wanjiang Li; Teng Cai; Xueqin Lu; Yule Han; Dilibaierkezi kudisi; Guohua Chang; Ke Dong; Guangyin Zhen (Chemical Engineering Journal, 2023)

Superwettable Surface-Dependent efficiently electrocatalytic water splitting based on their excellent liquid adsorption and gas desorption - Fei Zhang; Ran Zhao; Yiran Wang; Lu Han; Jianmin Gu; Zhimin Niu; Yiming Yuan; Nianrui Qu; Jingxin Meng; Desong Wang (Chemical Engineering Journal, 2023)

Synergistic effect of different configurations on the anionic redox reaction in Na-deficient oxides for sodium ion batteries - Qiong Liu; Wei Zheng; Xin Su; Xuan Zhang; Ning Han; Zhenyu Wang; Jiangshui Luo; Zhouguang Lu; Jan Fransaer (Chemical Engineering Journal, 2023)

Inspired by philosophizing of “point to area”: Ion pre-intercalation induces the reconstitution of interlayer environment of MXene for lithium storage - Miao Liu; Xin Qu; Yixuan Wang; Yukai Zhang; Cuimei Zhao; Bo Liu; Xiangxin Xue; Junkai Zhang; Zhao Wang; Jiaming Li; Wenjuan Han; Shichong Xu; et al. (Chemical Engineering Journal, 2023)

Ultrathin metal organic framework nanosheets with rich defects for enhanced fluoride removal - Junyu Su; Maosen Yuan; Lu Han; Hongxia Deng; Jiahao Chang; Yuting Zhuang; Jinyi Wang; Yue Zhang (Chemical Engineering Journal, 2023)

Salt Bridge-intermediated three phase decoupling electrolytes for high voltage electrolytic aqueous Zinc-Manganese dioxides battery - Qi Xu; Qi-Xing Xie; Tong Xue; Gao Cheng; Jian-Dong Wu; Lan Ning; Xiang-Hui Yan; You-Jun Lu; Zhong-Li Zou; Bei-Ping Wang; Feng-Lan Han (Chemical Engineering Journal, 2023)

Fabrication of alginate-based multi-crosslinked biomembranes for direct methanol fuel cell application - Bin Wang; Xing Han; Yi Wang; Lu Kang; Yudong Yang; Liying Cui; Shuangling Zhong; Xuejun Cui (Carbohydrate Polymers, 2023)

Whole cell of pure Clostridium butyricum CBT-1 from anaerobic bioreactor effectively hydrolyzes agro-food waste into biohydrogen - Tawaf Ali Shah; Li Zhihe; Li Zhiyu; Andong Zhang; Di Lu; Wang Fang; Han Xuan (Environmental Science and Pollution Research, 2023)

A novel ADA-coated UCNPs@NB sensing platform combined with nucleic acid amplification for rapid detection of Escherichia coli - Yaqi Song; Min Chen; Lu Han; Zhongyu Yan; Leiqing Pan; Kang Tu (Analytica Chimica Acta, 2023)

Recovery of nutrients from aquaculture wastewater: Effects of light quality on the growth, biochemical composition, and nutrient removal of Chlorella sorokiniana - Yuqing He; Jie Lian; Lan Wang; Lu Tan; Fahad Khan; Yanhua Li; Hongxia Wang; Céline Rebours; Danxiang Han; Qiang Hu (Algal Research, 2023)

Control measure implications of COVID-19 infection in healthcare facilities reconsidered from human physiological and engineering aspects - Ying-Fei Yang; Yi-Jun Lin; Shu-Han You; Tien-Hsuan Lu; Chi-Yun Chen; Wei-Min Wang; Chung-Min Liao (Environmental Science and Pollution Research, 2022)

Age and sex differences in in-air vocalization characteristics of spotted seal pups from newborn to 1 year old in captivity - Peijun Zhang; Liangliang Yang; Jiabo Han; Yong Yang; Zhichuang Lu; Songhai Li (Frontiers in Marine Science, 2022)
Acoustic parameters of spotted seals ( Phoca largha ), including the duration, peak frequency, and peak-to-peak source level, are reported to vary between different ages and sexes; however, to our knowledge, the vocal ontogeny of the spotted seal from newborn to 1 year old is yet to be studied. In the present study, we recorded and analyzed vocalizations of human-cared spotted seals from the Liaodong Bay colony from newborn to 1 year old, aiming to document the first-year development of seal vocalizations. We divided the spotted seal pups into four age groups (i.e., 1–3-month, 4–6-month, 7–9-month, and 10–12-month groups) for both sexes. The results show significant differences in sex patterns in sound parameters in terms of duration, peak frequency, and peak-to-peak source level. The vocalizations of female seal pups were longer in duration but lower in peak frequency and peak-to-peak source level than those of male pups. All three sound parameters were significantly different across different age groups. Specifically, the 1–3-month group had significantly lower values in duration, peak frequency, and peak-to-peak source level than the three other age groups. The 10–12-month group had significantly higher values in duration and peak-to-peak source level than the three other age groups. Our results also indicate a sex-specific development pattern of seal vocalizations from 1 year old until sexual maturity. Our findings will benefit the evaluation of anthropogenic noise impacts on spotted seal pups and further conservation of the seal population.

Estimating fractional cover of saltmarsh vegetation species in coastal wetlands in the Yellow River Delta, China using ensemble learning model - Zhanpeng Wang; Yinghai Ke; Dan Lu; Zhaojun Zhuo; Qingqing Zhou; Yue Han; Peiyu Sun; Zhaoning Gong; Demin Zhou (Frontiers in Marine Science, 2022)
Saltmarshes in coastal wetlands provide important ecosystem services. Satellite remote sensing has been widely used for mapping and classification of saltmarsh vegetation, however, medium-spatial-resolution satellite datasets such as Landsat-series imagery may induce mixed pixel problems over saltmarsh landscapes which are spatially heterogeneous. Sub-pixel fractional cover estimation of saltmarsh vegetation at species level are required to better understand the distribution and canopy structure of saltmarsh vegetation. In this study, we presented an approach framework for estimating and mapping the fractional cover of major saltmarsh species in the Yellow River Delta, China based on time series Landsat 8 Operational Land Imager data. To solve the problem that the coastal area is frequently covered by clouds, we adopted the recently developed virtual image-based cloud removal (VICR) algorithm to reconstruct missing image values under the cloud/cloud shadows over the time series Landsat imagery. Then, we developed an ensemble learning model (ELM), which incorporates Random Forest Regression (RFR), K-Nearest Neighbor Regression (KNNR) and Gradient Boosted Regression Tree (GBRT) based on temporal-spectral features derived from the time-series cloudless images to estimate the fractional cover of major vegetation types, i.e., Phragmites australis , Suaeda salsa and the invasive species, Spartina alterniflora . High spatial resolution imagery acquired by the Unmanned Aerial Vehicle and Gaofen-6 satellites were used for reference sample collections. The results showed that our approach successfully estimated the fractional cover of each saltmarsh species (average of R-square:0.891, RMSE: 7.48%). Through four scenarios of experiments, we found that the ELM is advantageous over each individual model. When the images during key months were absent, cloud removal for the Landsat images considerably improved the estimation accuracies. In the study area, Spartina alterniflora covers the largest area (5753.97 ha), followed by Phragmites australis with spatial extent area of 4208.4 ha and Suaeda salsa of 1984.41 ha. The average fractional cover of S. alterniflora was 58.45%, that of P. australis was 51.64% and that of S.salsa was 51.64%.

Construction of a Direct Z-Type Heterojunction Relying on Mos2 Electronic Transfer Platform Towards Enhanced Photodegradation Activity of Tetracycline - Xinlin Liu; Jiaqi Wang; Guosheng Zhou; Liguang Tang; Yangrui Xu; Changchang Ma; Ziran Chen; Song Han; Ming Yan; Ziyang Lu (Water, Air, & Soil Pollution, 2022)

Groundwater contamination source-sink analysis based on random statistical method for a practical case - Han Wang; Wenxi Lu (Stochastic Environmental Research and Risk Assessment, 2022)

Longitudinal Abnormalities in Brain Structure in COVID-19 Patients - Xiaoxing Liu; Wei Yan; Tangsheng Lu; Ying Han; Lin Lu (Neuroscience Bulletin, 2022)

Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson’s Disease - Cheng-Jie Li; Li-Ge Zhang; Lu-Bing Liu; Meng-Qi An; Li-guo Dong; Han-Ying Gu; Yong-Ping Dai; Fen Wang; Cheng-Jie Mao; Chun-Feng Liu (Molecular Neurobiology, 2022)

Photoacclimation caused by high frequency flashing light assists Chlorella sp. M-12 wastewater treatment and biomass accumulation in dark color biogas slurry - Chaorui Chen; Fan Tao; Ting Han; Fengzheng Gao; Taili Dong; Weizhong Jiang; Haifeng Lu; Yuanhui Zhang; Baoming Li (Journal of Applied Phycology, 2022)

GITRL impairs the immunosuppressive function of MDSCs via PTEN-mediated signaling pathway in experimental Sjögren syndrome - Jie Tian; Beibei Zhang; Qingfang Yuan; Xueqing Sun; Na Peng; Bo Zhu; Chang Liu; Xiaoran Wang; Man Han; Meng Cao; Fan Xiao; Shengjun Wang; et al. (Inflammation Research, 2022)

Rock thin sections identification under harsh conditions across regions based on online transfer method - Biao Wang; Guoqing Han; He Ma; Liying Zhu; Xingyuan Liang; Xin Lu (Computational Geosciences, 2022)

Immunogenicity and protective efficacy of a DNA vaccine inducing optimal expression of the SARS-CoV-2 S gene in hACE2 mice - Zhuo-xin Li; Sheng Feng; He Zhang; Xin-yu Zhuang; Chao Shang; Shi-yu Sun; Ji-cheng Han; Yu-biao Xie; Jin-yong Zhang; Wei Wang; Cheng-hui Li; Guan-yu Zhao; et al. (Archives of Virology, 2022)

Effects of dietary glutathione on the growth performance, skin mucus antioxidant capacity, and immune responses of juvenile taimen Hucho taimen - Chang’an Wang; Shaoxia Lu; Ze Fan; Shicheng Han; Yang Liu; Haibo Jiang; Hongbai Liu (Aquaculture International, 2022)

Phosphorus additions imbalance terrestrial ecosystem C:N:P stoichiometry - Yuan Sun; Cuiting Wang; Xinli Chen; Shirong Liu; Xingjie Lu; Han Y. H. Chen; Honghua Ruan (Global Change Biology, 2022)
Carbon (C):nitrogen (N):phosphorus (P) stoichiometry in plants, soils, and microbial biomass influences productivity and nutrient cycling in terrestrial ecosystems. Anthropogenic inputs of P to ecosystems are increasing; however, our understanding of the impacts of P addition on terrestrial ecosystem C:N:P ratios remains elusive. By conducting a meta‐analysis with 1413 paired observations from 121 publications, we showed that P addition significantly decreased plant, soil, and microbial biomass N:P and C:P ratios, but had negligible effects on C:N ratios. The reductions in N:P and C:P ratios became more evident as the P application rates and experimental duration increased. The P addition effects on terrestrial ecosystem C:N:P stoichiometry did not vary with ecosystem types or climates. Moreover, the responses of N:P and C:P ratios in soil and microbial biomass were associated with the responses of soil pH and fungi:bacteria ratios. Additionally, P additions increased net primary productivity, microbial biomass, soil respiration, N mineralization, and N nitrification, but decreased ammonium and nitrate contents. Decreases in plant N:P and C:P ratios were both negatively correlated to net primary productivity and soil respiration, but positively correlated to ammonium and nitrate contents; microbial biomass, soil respiration, ammonium contents, and nitrate contents all increased with declining soil N:P and C:P ratios. Our findings highlight that P additions could imbalance C:N:P stoichiometry and potentially impact the terrestrial ecosystem functions.

Decomposition analysis, decoupling status, and future trends of energy consumption in China’s iron and steel industry - Xiaoling Wang; Chang Lu; Baofeng Shi; Yu Chen; Zixuan Han; Jatin Nathwani (Environment, Development and Sustainability, 2022)

Experimental study of the mechanical properties of basalt fibre-reinforced concrete at elevated temperatures - Limin Lu; Fei Han; Yuwen Qin; Shaohua Wu; Guanglin Yuan; Qingli Zhao; Jeung-Hwan Doh (European Journal of Environmental and Civil Engineering, 2022)

Advances in DNA damage induced by environmental chemical carcinogens - Han Zhang; Wenfeng Lu; Yun Zhou; Yiguo Jiang (Genome Instability & Disease, 2022)

The effect of reservoir expansion from underground karst cave to surface reservoir on water quality in southwestern China - Meng Lu; Xiao-Dan Wang; Fu-Jun Yue; Zi-Han Liu; Zhi-Yu Shi; Ping Zhang (Environmental Science and Pollution Research, 2022)

Unique Pharmacology, Brain Dysfunction, and Therapeutic Advancements for Fentanyl Misuse and Abuse - Ying Han; Lu Cao; Kai Yuan; Jie Shi; Wei Yan; Lin Lu (Neuroscience Bulletin, 2022)

Dongia deserti sp. nov., Isolated from the Gurbantunggut Desert Soil - Chun-Yan Lu; Lei Dong; Dong Wang; Shuai Li; Bao-Zhu Fang; Ming-Xian Han; Feng Liu; Hong-Chen Jiang; Iftikhar Ahmed; Wen-Jun Li (Current Microbiology, 2022)

PDGFD switches on stem cell endothelial commitment - Weisi Lu; Peipei Xu; Boxiong Deng; Jianing Zhang; Ying Zhan; Xianchai Lin; Xiangzhong Xu; Zhaoxia Xia; Xiaoxi Yang; Xiaoling Zeng; Lijuan Huang; Bingbing Xie; et al. (Angiogenesis, 2022)
The critical factors regulating stem cell endothelial commitment and renewal remain not well understood. Here, using loss- and gain-of-function assays together with bioinformatic analysis and multiple model systems, we show that PDGFD is an essential factor that switches on endothelial commitment of embryonic stem cells (ESCs). PDGFD genetic deletion or knockdown inhibits ESC differentiation into EC lineage and increases ESC self-renewal, and PDGFD overexpression activates ESC differentiation towards ECs. RNA sequencing reveals a critical requirement of PDGFD for the expression of vascular-differentiation related genes in ESCs. Importantly, PDGFD genetic deletion or knockdown increases ESC self-renewal and decreases blood vessel densities in both embryonic and neonatal mice and in teratomas. Mechanistically, we reveal that PDGFD fulfills this function via the MAPK/ERK pathway. Our findings provide new insight of PDGFD as a novel regulator of ESC fate determination, and suggest therapeutic implications of modulating PDGFD activity in stem cell therapy.

Improving the bioavailability and bioactivity of garlic bioactive compounds via nanotechnology - Xiaoming Lu; Chaofan Wang; Meng Zhao; Jinxiang Wu; Zhonglu Niu; Xueli Zhang; Jesus Simal-Gandara; Ipek Süntar; Seid Mahdi Jafari; Xuguang Qiao; Xiaozhen Tang; Zhenlin Han; et al. (Critical Reviews in Food Science and Nutrition, 2022)

Genome-wide association and transcriptome studies reveal the segregation mechanism of mantle markings in three-way cross hybrid abalone - Qizhen Xiao; Shihai Gong; Yawei Shen; Yisha Lu; Xinlian Lai; Wenzhu Peng; Zekun Huang; Zhaofang Han; Hongjing Ji; Yang Gan; Xuan Luo; Weiwei You; et al. (Frontiers in Marine Science, 2022)
Trait separation which often appears in shellfish progeny, has been commercially used in shellfish breeding projects. A three-way cross hybrid abalone was produced with heterosis in growth performance and thermal tolerance, and with segregation in mantle marking. However, the inheritance mechanism of mantle marking is unclear. In this study, mantle marking was demonstrated to be a qualitative trait, following simple Mendelian inheritance, through inheritance pattern analysis of the presence of black markings on the mantle in five families of three-way cross of hybrid abalone. Thermal tolerance of abalone was assessed by the Arrhenius breakpoint temperature (ABT) of cardiac performance and a correlation between mantle marking and thermal tolerance of abalone was verified. A genome-wide association study (GWAS) for mantle marking was conducted using 603,067 high-quality single nucleotide polymorphisms (SNPs) derived from 57 individuals with mantle markings (Y group) and 58 individuals without mantle markings (N group). A total of 493 SNPs that were significantly ( p < 2.32E–07) associated with mantle markings were mainly distributed on chromosome 15. In the potential significantly associated region, 80 genes, including pigmentation-related genes PTPRT , PTPRC , PNCA , and CALM4 were annotated. Transcriptome analysis of the two groups showed that the expression levels of these genes ( PTPRT , DDT-b , ATOX1 , SLC6A3 , and GSTO1 ) were significantly different, and they may play important roles in the formation of mantle markings in the three-way cross hybrid abalone. Overall, our data provide valuable information for deciphering the phenotype differences of mantle marking in three-way cross hybrid abalone and help in the molecular marker-assisted breeding in abalone.

Simulations of sea fog case impacted by air–sea interaction over South China Sea - Liguo Han; Shuqin Zhang; Feng Xu; Jingjing Lü; Zebin Lu; Guiling Ye; Siqi Chen; Jianjun Xu; Jiaming Du (Frontiers in Marine Science, 2022)
A sea fog event in the South China Sea was simulated using a coupled ocean–atmosphere model (WRF for the atmosphere and ROMS for the ocean). Offshore and onshore visibility, liquid water content, air temperature, humidity, and wind speed observations and MICAPS data were utilized to validate the model results. The results of the coupled model were also compared with those of the uncoupled atmosphere model. Sea fog duration in the coupled model was closer to offshore and onshore observations, but the uncoupled model emptily forecasted offshore fog, and underreported onshore fog. Air–sea temperature difference played an important role in regulating the formation and dissipation of sea fog. The decrease of sea surface temperature in the coupled model cooled the low-level atmosphere, promoted the condensation of low-level water vapor, and increased the low-level water vapor. The decrease of air–sea temperature difference strengthened the low-level stable stratification, which weakened the horizontal wind speed and favored the formation and development of sea fog. Rising wind speed was the major driver of fog dissipation.

Exploring the environmental properties and resource utilization of construction waste in Beijing-Tianjin-Hebei region - Shuxin Hu; Fumin Ren; Jinming Jia; Can Cui; Changhong Guo; Nana Cui; Li Ma; Han Si; Tong Lu; Guotao Liu; Boyu Zhang; Junshi Liu (Environmental Science and Pollution Research, 2022)

Depletion of stem non-structural carbohydrates supports release of lateral branches from apical control in Quercus mongolica seedlings - Xiaoyi Han; Xinming Liang; Sujuan Ma; Yu Wang; Xiujun Lu (Trees, 2022)

miR-383-5p Regulated by the Transcription Factor CTCF Affects Neuronal Impairment in Cerebral Ischemia by Mediating Deacetylase HDAC9 Activity - Jun Shen; Qiu Han; Wangjun Li; Xiaochang Chen; Jingmin Lu; Jinyu Zheng; Shouru Xue (Molecular Neurobiology, 2022)

Exosomal targeting and its potential clinical application - Jiao He; Weihong Ren; Wei Wang; Wenyan Han; Lu Jiang; Dai Zhang; Mengqi Guo (Drug Delivery and Translational Research, 2022)
Exosomes are extracellular vesicles secreted by a variety of living cells, which have a certain degree of natural targeting as nano-carriers. Almost all exosomes released by cells will eventually enter the blood circulation or be absorbed by other cells. Under the action of content sorting mechanism, some specific surface molecules can be expressed on the surface of exosomes, such as tetraspanins protein and integrin. To some extent, these specific surface molecules can fuse with specific cells, so that exosomes show specific cell natural targeting. In recent years, exosomes have become a drug delivery system with low immunogenicity, high biocompatibility and high efficacy. Nucleic acids, polypeptides, lipids, or small molecule drugs with therapeutic function are organically loaded into exosomes, and then transported to specific types of cells or tissues in vivo, especially tumor tissues, to achieve targeting drug delivery. The natural targeting of exosome has been found and recognized in some studies, but there are still many challenges in effective clinical treatments. The use of the natural targeting of exosomes alone is incapable of accurately transporting the goods loaded to specific sites. Besides, the natural targeting of exosomes is still an open question in disease targeting and efficient gene/chemotherapy combined therapy. Engineering transformation and modification on exosomes can optimize its natural targeting and deliver the goods to a specific location, providing wide use in clinical treatment. This review summarizes the research progress of exosomal natural targeting and transformation strategy of obtained targeting after transformation. The mechanism of natural targeting and obtained targeting after transformation are also reviewed. The potential value of exosomal targeting in clinical application is also discussed. Graphical abstract

Cassane diterpenoids from Caesalpinia pulcherrima and their anti-inflammatory and α -glycosidase inhibitory activities - Xin Yun; Xiu-Mei Chen; Jia-Yun Wang; Wang Lu; Zi-Han Zhang; Young Ho Kim; Shi-Chun Zong; Chun-Huan Li; Jin-Ming Gao (Natural Product Research, 2022)

Heritability estimates for gonadal development traits and their genetic correlations with growth and heat tolerance traits in the Fujian Oyster Crassostrea angulata - Ziqiang Han; Xiang Guo; Zuoliang Lu; Yiheng Song; Ruimin Chen; Xiaojie Han; Shiqi Yu; Kang Tu; Liangjie Liu; Huayong Que (Frontiers in Marine Science, 2022)
Improving the progress of breeding is the main purpose of breeders, and shorting the reproductive cycle is one of the ways to improve the breeding progress. Although the reproductive cycle of Crassostrea angulata can be shortened from one year to half a year by selecting precocious individuals, little is known about whether this selection will accelerate their gonadal development or disturb their selection for productive traits. Here, the heritability of gonadal development traits (gametogenic stage and egg diameter) and their genetic correlations with both growth traits (shell height at 4 and 12 months and total body weight at 12 months) and heat tolerance trait were estimated. The heritability for gametogenic stage was low (0.18 ± 0.09), while the egg diameter showed a high heritability (0.78 ± 0.30). These results suggest that selection for precocious individuals has little effect on the rate of gonadal development in the C. angulata , despite the effect may be greater in females than in males. The genetic correlations between gonadal development traits and both growth (-0.02–0.30) and heat tolerance traits (-0.08–0.34) were low and non-significant. These results suggest that selection for precocious individuals has negligible effects on their productive traits. Therefore, it is feasible to double the breeding efficiency of C. angulata by halving their reproductive cycle.

Wheat genomic study for genetic improvement of traits in China - Jun Xiao; Bao Liu; Yingyin Yao; Zifeng Guo; Haiyan Jia; Lingrang Kong; Aimin Zhang; Wujun Ma; Zhongfu Ni; Shengbao Xu; Fei Lu; Yuannian Jiao; et al. (Science China Life Sciences, 2022)

An Improved Monkey Model of Myocardial Ischemic Infarction for Cardiovascular Drug Development - Keke Wang; Pengfei Han; Lu Huang; Ying Xiao; Jianglong Hou; Pingliang Yang; Yuping Xie; Jindan Cai; Hongge Wang; Y. James Kang (Cardiovascular Toxicology, 2022)

Genetic Variations and Expansion of the Blue Swimmer Crab (Portunus pelagicus) in Southeast Asia - Yu-Ming Lu; Chun-Han Shih; Po-Cheng Chen; Wei-Chieh Kao; Ying-Chou Lee; Yu-San Han; Tzong-Der Tzeng (Journal of Marine Science and Engineering, 2022)
Blue swimmer crabs (Portunus pelagicus) primarily inhabit the coastal regions of Southeast Asia. This study aimed to examine their population genetic structure, phylogeography, and historical demography by applying partial sequences to the control region in the mitochondrial DNA. The analysis focused on 6 populations comprising 166 individual samples collected from Taiwan (Kezailiao Kaohsiung (KK) and Penghu (PH)), mainland China (Xiamen (XM) and Hong Kong (HK)), Vietnam (Hanoi (VN)), and Singapore (SGP). The estimated nucleotide diversity (π) for all of the samples was 0.062, with values ranging between 0.018 (PH) and 0.045 (HK). Our study collected 116 haplotypes and classified them into lineages A and B. The XM, HK, VN, and SGP populations made up lineage A, and the PH and KK populations comprised lineage B. For each lineage, the results highlighted indications of demographic expansion. Lineage A can be traced back to the second-to-last interglacial period, while lineage B possibly originated in the last glacial period. There were significant differences in the FST values among the six populations, except for the pairs HK–XM and PH–KK. In conclusion, the phylogeography and genetic structure of P. pelagicus in Southeast Asia were potentially affected by the Pleistocene glacial cycles and human introduction. These findings further highlight the possible dispersal routes of P. pelagicus throughout Southeast Asia.

Identification of novel biofilm genes in avian pathogenic Escherichia coli by Tn5 transposon mutant library - Jiangang Hu; Yi Gu; Huiqi Lu; Muhammad Akmal Raheem; Fangheng Yu; Xiangpeng Niu; Jiakun Zuo; Huifang Yin; Cuiqin Huang; Xiangjun Song; Jian Tu; Wen Zhou; et al. (World Journal of Microbiology and Biotechnology, 2022)

Chromosomal mapping of a locus associated with adult-stage resistance to powdery mildew from Agropyron cristatum chromosome 6PL in wheat - Yida Lin; Shenghui Zhou; Xuezhong Liang; Baojin Guo; Bing Han; Haiming Han; Jingpeng Zhang; Yuqing Lu; Zhi Zhang; Xinming Yang; Xiuquan Li; Weihua Liu; et al. (Theoretical and Applied Genetics, 2022)

Glucose metabolism patterns: A potential index to characterize brain ageing and predict high conversion risk into cognitive impairment - Jiehui Jiang; Can Sheng; Guanqun Chen; Chunhua Liu; Shichen Jin; Lanlan Li; Xueyan Jiang; Ying Han; Michael W. Weiner; Paul Aisen; Ronald Petersen; Clifford R. Jack; et al. (GeroScience, 2022)

Prediction of Water Inflow into Tunnel Crossing Intersecting Faults Based on IDB Seepage Model - Jing Wu; Li Wu; Ya-ni Lu; Yan-hua Han; Jun-jie Jiang (Geotechnical and Geological Engineering, 2022)

Integrated analysis of the miRNA and mRNA expression profiles in Leiocassis longirostris at gonadal maturation - Han Zhao; Lu Zhang; Qiang Li; Zhongmeng Zhao; Yuanliang Duan; Zhipeng Huang; Hongyu Ke; Chao Liu; Huadong Li; Lu Liu; Jun Du; Zhen Wei; et al. (Functional & Integrative Genomics, 2022)

An improved optimization algorithm for a multi-depot vehicle routing problem considering carbon emissions - Xujin Pu; Xulong Lu; Guanghua Han (Environmental Science and Pollution Research, 2022)

Comparative study on characteristics of mandarin peel extracts by biological processing - Jiamin Chen; Xinling Han; Yulai Wu; Lu Liu; Jianxing Yu; Jiayou Li; Yang Zhang; Yaling Xu (Archives of Microbiology, 2022)

Longitalea arenae gen. nov., sp. nov. and Longitalea luteola sp. nov., two new members of the family Chitinophagaceae isolated from desert soil - Shuai Li; Lei Dong; Jia-Rui Han; Guo-Yuan Shi; Chun-Yan Lu; Lu Xu; Wen-Hui Lian; Dalal Hussien M. Alkhalifah; Wael N. Hozzein; Wen-Jun Li (Archives of Microbiology, 2022)

Effect of Angiogenesis in Bone Tissue Engineering - Jianhao Huang; Qixiu Han; Meng Cai; Jie Zhu; Lan Li; Lingfeng Yu; Zhen Wang; Gentao Fan; Yan Zhu; Jingwei Lu; Guangxin Zhou (Annals of Biomedical Engineering, 2022)

Assessing the effect of probiotics on tilapia lake virus‐infected tilapia: Transmission and immune response - Ying‐Fei Yang; Jidapa Yamkasem; Win Surachetpong; Yi‐Jun Lin; Shu‐Han You; Tien‐Hsuan Lu; Chi‐Yun Chen; Wei‐Min Wang; Chung‐Min Liao (Journal of Fish Diseases, 2022)
Probiotics have been used to alleviate disease transmission in aquaculture. However, there are limited studies on probiotic use in modulating tilapia lake virus (TiLV). We assessed commercially available probiotic supplements used in TiLV‐infected tilapia and performed mortality and cohabitation assays. We developed a mechanistic approach to predict dose–response interactions of probiotic effects on mortality and immune gene response. We used a susceptible–infected–mortality disease model to assess key epidemiological parameters such as transmission rate and basic reproduction number ( R 0 ) based on our viral load dynamic data. We found that the most marked benefits of probiotics are significantly associated with immune system enhancements (~30%) and reductions in disease transmission (~80%) and R 0 (~70%) in tilapia populations, resulting in a higher tolerance of farming densities (~400 fold) in aquaculture. These findings provide early insights as to how probiotic use‐related factors may influence TiLV transmission and the immune responses in TiLV‐infected tilapia. Our study facilitates understanding the mode of action of probiotics in disease containment and predicting better probiotic dosages in diet and supplements to achieve the optimal culturing conditions. Overall, our analysis assures that further study of rationally designed and targeted probiotics, or mechanistic modelling is warranted on the basis of promising early data of this approach.

Effect of porewater salinity on compression behaviors and hydraulic conductivity of soft marine clay - Jie Yin; Zhijun Lu; Weijuan Geng; Wenxia Han; Abdulmalik A. Hudu (Marine Georesources & Geotechnology, 2022)

Wildfire detection through deep learning based on Himawari-8 satellites platform - Changcheng Ding; Xiaoyu Zhang; Jianyu Chen; Shuchang Ma; Yanfang Lu; Wencong Han (International Journal of Remote Sensing, 2022)

Isolation and characterization of SGF3, a novel Microviridae phage infecting Shigella flexneri - Han Lu; Wenbin Xiong; Zong Li; Peihan Yan; Ruyin Liu; Xinchun Liu (Molecular Genetics and Genomics, 2022)

Agricultural non-point sources and their effects on chlorophyll-a in a eutrophic lake over three decades (1985–2020) - Jialin Wang; Jianzhong Lu; Zhan Zhang; Xingxing Han; Chen Zhang; Xiaoling Chen (Environmental Science and Pollution Research, 2022)

Influence of accelerometer type on uncertainties in recorded ground motions and seismic damage assessment - Wenjie Liao; Yifan Fei; Farid Ghahari; Wenyang Zhang; Peng-Yu Chen; Asli Kurtulus; Chu-Han Yen; Qingle Cheng; Xinzheng Lu; Ertugrul Taciroglu (Bulletin of Earthquake Engineering, 2022)

Grain size-dependent geochemical evidence reveals provenance and implications of aeolian sands, Dinggye region, southern Tibet - You-gui Chen; Mei-hui Pan; Ze-wen Hao; Yu-han Qi; Chen-lu Li (Journal of Mountain Science, 2022)

Effects of Sporisorium reiliana polysaccharides and Phoenix dactylifera monosaccharides on the gut microbiota and serum metabolism in mice with fructose-induced hyperuricemia - Ziyan Wang; Zhixuan Zhang; Chenyang Lu; Jun Zhou; Zhonghua Wang; Jiaojiao Han; Xiurong Su (Archives of Microbiology, 2022)

Concentration, Spatial-Temporal Distribution, and Bioavailability of Dissolved Reactive Iron in Northern Coastal China Seawater - Chenchen Wang; Yongsheng Luan; Dawei Pan; Yuxi Lu; Haitao Han; Shenghui Zhang (Journal of Marine Science and Engineering, 2022)
The concentrations of total dissolved iron (TdFe) and dissolved reactive iron (DrFe) in the Northern coastal China seawater (Yantai Sishili Bay) in 2018 were determined using cathodic stripping voltammetry (CSV). It was found that while the concentrations of TdFe ranged from 27.8 to 82.0 nM, DrFe concentrations changed in a much narrower range from 6.8 to 13.3 nM. The annual mean concentrations of DrFe also ranged from 7.1 to 12.6 nM at the 12 sites monitored over the 4 years of the study (2017–2020). Considering the obvious changes in temperature (T), chlorophyll a (Chl a) concentrations (Chl a contents were higher in May, July and September than in March and November), and nutrients over a year in this zone, the consumption of DrFe was expected; the supplement of DrFe observed may have resulted from the transformation of strong organically complexed iron by photoreduction and cell surface reduction. Additionally, a pre-liminary conclusion was drawn based on the theoretical calculation of Fe* that the concentration of DrFe was sufficient to meet the phytoplankton demand.

Introgression of chromosome 1P from Agropyron cristatum reduces leaf size and plant height to improve the plant architecture of common wheat - Xiao Wang; Bohui Han; Yangyang Sun; Xilu Kang; Meng Zhang; Haiming Han; Shenghui Zhou; Weihua Liu; Yuqing Lu; Xinming Yang; Xiuquan Li; Jinpeng Zhang; et al. (Theoretical and Applied Genetics, 2022)

Holocene climate evolution: information from the Lacustrine–Fluvial sediment in North China - Han-tao Ni; Yong Wang; Fei Tian; Pei-yi Yao; Lu-peng Yuan; Meng-ni Ye (Journal of Paleolimnology, 2022)

Impact of CT-Based and MRI-Based Attenuation Correction Methods on 18 F-FDG PET Quantification Using PET Phantoms - Cheng-Han Wu; Chun-Yuan Tu; Li-Chen Shen; Yueh-Hsun Lu; Bang-Hung Yang (Journal of Medical and Biological Engineering, 2022)

C2CD4A/B variants in the predisposition of lung cancer in the Chinese Han population - Feifei Han; Lu Qian; Yi Zhang; Ping Liu; Rui Li; Mingwei Chen (Functional & Integrative Genomics, 2022)

Soil acidification induced decline disease of Myrica rubra: aluminum toxicity and bacterial community response analyses - Han Chen; Haiying Ren; Jingjing Liu; Yu Tian; Shenggao Lu (Environmental Science and Pollution Research, 2022)

Energy performance of European countries by considering the role of forest - Liang Chun Lu; Shih-Yung Chiu; Yung-Ho Chiu; Tzu-Han Chang; William Tang (Environmental Science and Pollution Research, 2022)

Is the “pollution haven hypothesis” valid for China’s carbon trading system? A re-examination based on inter-provincial carbon emission transfer - Xin Nie; Zhoupeng Chen; Han Wang; Jianxian Wu; Xingyi Wu; Bo Lu; Li Qiu; Yuanyuan Li (Environmental Science and Pollution Research, 2022)

The formation of biogenic reef stone: from coral skeleton to reef rubble - Yixin Li; Fengjuan Wang; Zhiyong Liu; Jinyang Jiang; Tingyu Han; Xin Liao; Chunpeng He; Zuhong Lu (Journal of Oceanography, 2022)

Evaluation of genetic variants in nucleosome remodeling and deacetylase (NuRD) complex subunits encoding genes and gastric cancer susceptibility - Yujuan Zhang; Guoquan Tao; Ping Liu; Kai Lu; Zhichao Han; Hanting Liu; Mulong Du; Meilin Wang; Haiyan Chu; Zhengdong Zhang (Archives of Toxicology, 2022)

Integrinβ3 mediates the protective effects of soluble receptor for advanced glycation end-products during myocardial ischemia/reperfusion through AKT/STAT3 signaling pathway - Xuejie Han; Xinying Guo; Jing Chang; Jie Zhang; Lu Chen; Hongxia Wang; Fenghe Du; Xiangjun Zeng; Caixia Guo (Apoptosis, 2022)

Effect of Culture Period and Stocking Density on Input Demand and Scale Economies of Milkfish (Chanos chanos) Polycultures with White Shrimp (Penaeus indicus) - Wei-Tse Pai; Christian Schafferer; Jie-Min Lee; Li-Ming Ho; Yung-Hsiang Lu; Han-Chung Yang; Chun-Yuan Yeh (Fishes, 2022)
Milkfish, Chanos chanos, is one of the major inland cultured fish species in Taiwan. Variations in land resources and climate have led to the application of two distinct culture practices of milkfish polycultures with white shrimp, Penaeus indicus. This study applies a translog cost function model to analyze the production scale economy and input demand price elasticity of four milkfish polyculture systems with two different culture periods (OWC and NOWC) and two different white shrimp–milkfish fry stocking ratios (low SMR: 10–55 fry/ha; high SMR: 56–100 fry/ha). The findings show that the four milkfish polyculture systems require different operational adjustments to increase production while reducing the average culture cost. More specifically, overwinter cultures (OWC) have economies of scale. Farmers may reduce the average cost by expanding the production scale. Non-overwinter polycultures (NOWC) with high SMR are at the stage of decreasing return to scale, meaning that gains in output of milkfish cannot reduce the average cost. In terms of input factor use, farmers of OWC systems with high SMR are sensitive to fluctuations in the fry price since fry constitutes the input factor exhibiting the highest own-price elasticity. Moreover, fry and feed of OWC households with high SMR have high levels of substitutability, whereas fry and other input exhibit substitutability in OWC systems with low SMR. In NOWC farming households with high SMR, fry and capital have substitutability. It is thus recommended to modify the input factor use according to the culture mode and the white shrimp–milkfish stocking density ratio. Moreover, the study found that NOWCs have considerably higher SMR than OWCs, which may lead to a deterioration of the water quality in NOWC fishponds and lower survival rates. It is thus recommended to reduce the SMR to 31:1 to achieve economies of scale in production and increase the survival rate of milkfish and white shrimp.

An implementation framework of blockchain-based hazardous waste transfer management system - Guanghan Song; Yujie Lu; Haibo Feng; Han Lin; Yang Zheng (Environmental Science and Pollution Research, 2022)

Recognition of a linear source contamination based on a mixed-integer stacked chaos gate recurrent unit neural network–hybrid sparrow search algorithm - Zidong Pan; Wenxi Lu; Han wang; Yukun Bai (Environmental Science and Pollution Research, 2022)

Pilot-scale microsand-ballasted flocculation of wastewater: turbidity removal, parameters optimization, and mechanism analysis - Yimin Sang; Taotao Lu; Xianchun Lu; Shuguang Wang; Xueting Shao; Yanhe Han; Lili Li (Environmental Science and Pollution Research, 2022)

Do Forests help environmental development of Cities in China? - Liang Chun Lu; Yung-ho Chiu; Shih-Yung Chiu; Tzu-Han Chang (Environment, Development and Sustainability, 2022)

Hypothermal Effects on Energy Supply for Ionocytes in Gills of Freshwater- and Seawater-Acclimated Milkfish, Chanos chanos - Chia-Hao Chang; Chia-Jui Liu; Wei-Jie Lu; Li-Yang Wu; Kuang-Jie Lai; Yu-Ting Lin; Tsung-Han Lee (Frontiers in Marine Science, 2022)
The milkfish, Chanos chanos , is an important aquaculture species that can be cultured in freshwater (FW) and seawater (SW) ponds because of its high euryhalinity. In winter, cold snap leading to high mortality of this tropical species is a critical issue for the aquaculture industry in Taiwan. Under hypothermal stress, however, changes in energy supply for osmoregulation of this euryhaline species is intriguing. In this study, we used an antibody against glycogen phosphorylase (GP) to identify glycogen-rich (GR) cells distributed adjacent to the mitochondria-rich (MR) ionocytes in milkfish gills. Glucose transporter 1 (GLUT1), which plays a major role in energy supply, was also identified and localized in GR cells. Moreover, the expression of indicators of aerobic metabolism and energy production, citrate synthase (CS) and cytochrome c oxidase (COX), were analyzed in gills of FW- and SW-acclimated milkfish to reveal different strategies of energy utilization under hypothermal stress. When exposed to a low-temperature environment, SW individuals used branchial glycogen and lactate to match the energy demands of aerobic metabolism in ionocytes, and elevated aerobic capacity to support and maintain normal functions in gills. However, branchial glycogen mainly localized in the GR cells of FW milkfish was not utilized under hypothermal stress. Meanwhile, a similar level of branchial COX activity and COXIV protein abundance at low temperatures between FW and SW milkfish indicated similar energy requirements in gills. This suggested that another source, but not branchial glycogen, maintained the energy demand in FW milkfish. The present study illustrated differential energy supply strategies in gills between SW- and FW-acclimated milkfish for osmoregulation under low temperatures.

Molecular identification and expression analysis of five sucrose synthase genes in Sorghum Bicolor - Yelei Lu; Shaopeng Han; Chao Zhou; Yunwei Cheng; Yang Lv; Gongjian Zeng; Dechun Zhang; Xinqiang Gao; Yongfeng Hu; Xiangling Shen (Physiology and Molecular Biology of Plants, 2022)

Targeting GATA1 and p2x7r Locus Binding in Spinal Astrocytes Suppresses Chronic Visceral Pain by Promoting DNA Demethylation - Yan-Yan Wu; Hai-Long Zhang; Xiaomin Lu; Han Du; Yong-Chang Li; Ping-An Zhang; Guang-Yin Xu (Neuroscience Bulletin, 2022)
Irritable bowel syndrome is a gastrointestinal disorder of unknown etiology characterized by widespread, chronic abdominal pain associated with altered bowel movements. Increasing amounts of evidence indicate that injury and inflammation during the neonatal period have long-term effects on tissue structure and function in the adult that may predispose to gastrointestinal diseases. In this study we aimed to investigate how the epigenetic regulation of DNA demethylation of the p2x7r locus guided by the transcription factor GATA binding protein 1 (GATA1) in spinal astrocytes affects chronic visceral pain in adult rats with neonatal colonic inflammation (NCI). The spinal GATA1 targeting to DNA demethylation of p2x7r locus in these rats was assessed by assessing GATA1 function with luciferase assay, chromatin immunoprecipitation, patch clamp, and interference in vitro and in vivo . In addition, a decoy oligodeoxynucleotide was designed and applied to determine the influence of GATA1 on the DNA methylation of a p2x7r CpG island. We showed that NCI caused the induction of GATA1, Ten-eleven translocation 3 (TET3), and purinergic receptors (P2X7Rs) in astrocytes of the spinal dorsal horn, and demonstrated that inhibiting these molecules markedly increased the pain threshold, inhibited the activation of astrocytes, and decreased the spinal sEPSC frequency. NCI also markedly demethylated the p2x7r locus in a manner dependent on the enhancement of both a GATA1–TET3 physical interaction and GATA1 binding at the p2x7r promoter. Importantly, we showed that demethylation of the p2x7r locus (and the attendant increase in P2X7R expression) was reversed upon knockdown of GATA1 or TET3 expression, and demonstrated that a decoy oligodeoxynucleotide that selectively blocked the GATA1 binding site increased the methylation of a CpG island in the p2x7r promoter. These results demonstrate that chronic visceral pain is mediated synergistically by GATA1 and TET3 via a DNA-demethylation mechanism that controls p2x7r transcription in spinal dorsal horn astrocytes, and provide a potential therapeutic strategy by targeting GATA1 and p2x7r locus binding.

Synthesis, antifungal activity, and molecular dynamics study of novel geranyl aromatic sulfonamide compounds as potential complex III inhibitors - Xinning Song; Zhiyang Jiang; Jianing Li; Xingxing Lu; Qing Han; Kai Zhu; Huilin Li; Yun Ling; Hongxia Duan (Medicinal Chemistry Research, 2022)

Sodium tanshinone IIA sulfonate improves cognitive impairment via regulating Aβ transportation in AD transgenic mouse model - Hui-Han Ma; Can Wan; Lu-Di Zhang; Rong-Rong Zhang; Dong Peng; Li-Jun Qiao; Shi-Jie Zhang; Ye-Feng Cai; Hong-Qiang Huang (Metabolic Brain Disease, 2022)

Remediation of 1,2-dichlorobenzene contaminated soil by activated persulfate using green synthesized nanoscale zero valent iron: activation mechanism and degradation pathways - Jingchun Yan; Linchao Hu; Weiguo Gao; Lei Yang; Linbo Qian; Lu Han; Mengfang Chen (Journal of Soils and Sediments, 2022)

Lanthanum Impairs Learning and Memory by Activating Microglia in the Hippocampus of Mice - Licheng Yan; Jinghua Yang; Miao Yu; Wenchang Sun; Yarao Han; Xiaobo Lu; Cuihong Jin; Shengwen Wu; Yuan Cai (Biological Trace Element Research, 2022)

Spatial-temporal Evolution Characteristics and Decoupling Analysis of Influencing Factors of China’s Aviation Carbon Emissions - Ruiling Han; Lingling Li; Xiaoyan Zhang; Zi Lu; Shaohua Zhu (Chinese Geographical Science, 2022)

An assessment of statistical interpolation methods suited for gridded rainfall datasets - Yuexiao Liu; Lu Zhuo; Maria Pregnolato; Dawei Han (International Journal of Climatology, 2022)
Accurate spatial distribution information of rainfall is essential to rainfall‐induced hazard predictions and statistical interpolation methods may serve as a useful tool to produce a detailed distribution from coarse data sources. Although numerous comparison studies about different interpolation methods have been conducted on irregular rain‐gauge networks, there is a need to perform such work on the increasingly available gridded rainfall data. Carried out in the Emilia‐Romagna region (Italy) from 2008 to 2018, this study aims to examine accurate and appropriate interpolation methods to produce finer rainfall surface maps based on the 0.25° × 0.25° ERA5 gridded precipitation datasets. Five interpolation techniques, namely Thiessen polygons, Inverse Distance Weighting (IDW), Thin Plate Spline (TPS), Ordinary Kriging (OK) and ordinary Co‐Kriging (CoK), have been selected and compared at different time scales (annual, monthly and annual maximum daily precipitation). To assess the accuracy, the leave‐one‐out‐cross‐validation test was used by using the indexes of Bias, correlation coefficient, the Nash‐Sutcliffe Efficiency, Root Mean Square Error and the Kling‐Gupta Efficiency (KGE). Additionally, visual inspections are employed to evaluate the plausibility of the interpolated maps. Results show: (a) All five interpolation methods have certain capabilities to improve spatial resolution, but they fail on accuracy at the daily scale. The OK generally outperforms the other four methods, while TPS shows better performance through the visual inspection at the monthly scale; (b) Unlike in the case of the interpolation using conventional point‐based rain‐gauge data, the multivariate method CoK is inferior to the univariate ones and the p ‐power of the IDW also differs and (c) Winter and spring results are better than those of summer and autumn. This study has provided useful guidance on choosing suitable rainfall interpolation methods for gridded datasets, which can be expanded in other regions and data sources to explore the generality of the conclusions.

Phytoplankton Species Diversity Patterns and Associated Driving Factors in China’s Jiulong River Estuary: Roles That Nutrients and Nutrient Ratios Play - Feiyang Ge; Zhiyuan Ma; Bin Chen; Yu Wang; Xiaoqian Lu; Shenqun An; Dian Zhang; Wanting Zhang; Weiwei Yu; Wenxuan Han; Xingguang Yu; Zhenghua Liu; et al. (Frontiers in Marine Science, 2022)
Understanding diversity patterns and associated driving factors are the critical topics in macroecology and conservation biology. Phytoplankton are highly susceptible to environmental changes in estuaries, particularly eutrophication. This study examined phytoplankton alpha and beta diversity using investigation data in May (springtime), August (summer) and November (autumn) 2009 in China’s Jiulong River estuary, where it was easily polluted because of considerable discharge from a highly dense human population and low self-purification capacity with its limited river basin area, potentially resulting in eutrophication and then influencing phytoplankton diversity. Potential influencing factors were also explored, including dissolved oxygen, salinity, nutrients, nutrient ratios, geographic and hydrologic distance, and so on. The results indicated that Shannon’s index ( H’ ) and Pielou’s index ( J ) decreased from the estuary’s upper to middle and then increased from middle to lower reaches, Simpson’s ( D ) observed the opposite trend and species number ( S ) gradually increased from the estuary’s upper to lower reaches. For beta diversity, all the indices showed a gradual decrease trend from the estuary’s upper to lower reaches, where also, turnover dominated beta diversity for all seasons. It is noteworthy that the significant roles that nutrients and nutrient ratios played in shaping phytoplankton diversity patterns and the nutrient balance were characterized by excess nitrogen (N) and silicon (Si) and limited phosphorus (P), which could potentially cause diatom blooms. Findings also showed that decreasing Si concentrations can help to reduce overall pollution levels as well as the restoration of the estuary’s ecosystem better than just reducing N alone. Accordingly, this study advocates for the protection of the entire estuary system with particular emphasis on its upper reaches. Moreover, greater attention should also be paid to impacts associated with N input and nutrient ratio trade-offs to the prospective watershed management of this estuary. This study provides a practical approach to explore estuarine diversity in a comprehensive way, which can inform effective biodiversity conservation and also be applied to other marine ecosystems to better guide sustainable management and conservation practices.

Screening and identification of HLA-A2-restricted neoepitopes for immunotherapy of non-microsatellite instability-high colorectal cancer - Ranran Shi; Yubing Li; Ling Ran; Yu Dong; Xiuman Zhou; Jingwen Tang; Lu Han; Mingshuang Wang; Liwei Pang; Yuanming Qi; Yahong Wu; Yanfeng Gao (Science China Life Sciences, 2022)

Early changes to the extracellular space in the hippocampus under simulated microgravity conditions - Yajuan Gao; Hongbin Han; Jichen Du; Qingyuan He; Yanxing Jia; Junhao Yan; Hui Dai; Bin Cui; Jing Yang; Xunbin Wei; Liu Yang; Rui Wang; et al. (Science China Life Sciences, 2022)

Aligned Organization of Synapses and Mitochondria in Auditory Hair Cells - Jing Liu; Shengxiong Wang; Yan Lu; Haoyu Wang; Fangfang Wang; Miaoxin Qiu; Qiwei Xie; Hua Han; Yunfeng Hua (Neuroscience Bulletin, 2022)

Analysis and Research on Blasting Network Delay of Deep-Buried Diversion Tunnel Crossing Fault Zone Based on EP-CEEMDAN-INHT - Jing Wu; Li Wu; Miao Sun; Ya-ni Lu; Yan-hua Han (Geotechnical and Geological Engineering, 2022)

Oxidative degradation of tetracycline using peroxymonosulfate activated by cobalt-doped pomelo peel carbon composite - Shuang Han; Pengfei Xiao; Lu An; Dedong Wu (Environmental Science and Pollution Research, 2022)

Groundwater contamination source identification using improved differential evolution Markov chain algorithm - Yukun Bai; Wenxi Lu; Jiuhui Li; Zhengbo Chang; Han Wang (Environmental Science and Pollution Research, 2022)

Environmental regulations and enterprises innovation performance: the role of R&D investments and political connections - Jintao Zhang; Zhen Yang; Li Meng; Lu Han (Environment, Development and Sustainability, 2022)

Spatial–temporal evolution pattern and prediction analysis of flood disasters in China in recent 500 years - Cuixia Wei; Bing Guo; Hailing Zhang; Baomin Han; Xiangshen Li; Huihui Zhao; Yuefeng Lu; Chao Meng; Xiangzhi Huang; Wenqian Zang; Hongwei Wu (Earth Science Informatics, 2022)

Sphingobacterium bovistauri sp. nov., Isolated from the Faeces of Bos Taurus - Qiong Wang; Zhi-Qin Fang; Chen-Lu Zhang; Jian-Qiang Shen; Jian-Dong Lai; Xiu-Lin Han; Tao Lu (Current Microbiology, 2022)

Consistency correction of echo intensity data for multiple radar systems and its application in quantitative estimation of typhoon precipitation - Shuai Zhang; Jing Han; Bingke Zhao; Zhigang Chu; Jie Tang; Limin Lin; Xiaoqin Lu; Jiaming Yan (Frontiers of Earth Science, 2022)

Numerical simulation of water inrush in a tunnel crossing faults: impacts of fault width, damage zone width, and fault permeability - Jing Wu; Xintong Wang; Li Wu; Ya-ni Lu; Yan-hua Han (Arabian Journal of Geosciences, 2022)

Rapid visual detection of Micropterus salmoides rhabdovirus using recombinase polymerase amplification combined with lateral flow dipsticks - Zizhao Feng; Xin Chu; Minzhen Han; Chenwei Yu; Yousheng Jiang; Hao Wang; Liqun Lu; Dan Xu (Journal of Fish Diseases, 2022)
Largemouth bass ( Micropterus salmoides ) is an important freshwater‐cultured species in China. Recently, a lethal and epidemic disease caused by Micropterus salmoides rhabdovirus (MSRV) results in huge economic losses to the largemouth bass industry. Current diagnostics for detecting MSRV are limited in sensitivity and speed and are inconvenient to be used for non‐laboratory detection. In this study, three rapid and convenient detection assays of MSRV by recombinase polymerase amplification (RPA) and lateral flow dipsticks (LFD), targeting the conserved sequences of the MSRV‐SS N gene, are described. With these RPA methods, the detection could achieve within 50 min at 38°C. Both methods of RPA‐AGE and RPA‐LFD could detect the viral DNA as low as 170 copies/μl of the MSRV standard plasmid and were 100‐fold more sensitive than that in the method of routine PCR. Meanwhile, these RPA methods were highly specific for the detection of MSRV and can be feasibly applied to the diagnostic of MSRV infection. In brief, RPA‐AGE, RPA‐LFD and RT‐RPA‐LFD provide convenient, rapid, sensitive and reliable methods that could improve field diagnosis of MSRV with limited machine resources, and would enhance the production of largemouth bass.

Phylogeography and Genetic Structure of the Swimming Crabs Portunus sanguinolentus (Herbst, 1783) in East Asia - Yu-Ming Lu; Chun-Han Shih; Po-Cheng Chen; Wei-Chieh Kao; Ying-Chou Lee; Yu-San Han; Tzong-Der Tzeng (Journal of Marine Science and Engineering, 2022)
The three-spot swimming crab (Portunus sanguinolentus) is mainly distributed in South East Asia. An analysis of mitochondrial control region partial sequences allows us to determine the population genetic structure, phylogeography and historical demography of this species in East Asia. The seven populations, which included 110 individuals, were collected from mainland China (Shanghai, SH, Xiamen, XM and Hong Kong, HK), Taiwan (Yilan, YL, Taichung, TC, Donggang, DG) and Singapore (Singapore, SGP). The nucleotide diversity (π) of all individuals was 0.01149, with values ranging from 0.00372 (SGP) to 0.01345 (YL). In total, 90 haplotypes have been identified, which can be divided into two major lineages: lineage A consists of specimens from SH, YL, XM, TC and DG, and lineage B corresponds to specimen from SGP. From the second to the most recent interglacial period, population expansion was observed in each lineage. However, a low level of genetic differentiation was also observed in the three-spotted swimming crab, P. sanguinolentus, according to FST values. Our results suggest that several past and present habitat configurations have shaped the genetic patterns of P. sanguinolentus until now. During Pleistocene glaciations, when sea levels were low, this species may have moved along the coast from Southeast Asia to China. It first colonized the Hong Kong area during this era. After sea levels rose and shorelines receded, it subsequently spread to the coast of mainland China.

CRISPR-Cas9-Mediated Gene Therapy in Neurological Disorders - Lihong Guan; Yawei Han; Ciqing Yang; Suxiang Lu; Jiang Du; Han Li; Juntang Lin (Molecular Neurobiology, 2022)

First report of a crinivirus infecting mulberry (Morus alba L.) in China - Peng Zhang; Yu Ma; Tao-Tao Han; William Kojo Smith; Jing Yu; Yong-Yuan Cheng; Quan-You Lu (Journal of Plant Pathology, 2022)

Video target detection of East Asian migratory locust based on the MOG2-YOLOv4 network - Zhao Bai; Zhan Tang; Lei Diao; Shuhan Lu; Xuchao Guo; Han Zhou; Chengqi Liu; Lin li (International Journal of Tropical Insect Science, 2022)

Advenella mandrilli sp. nov., a bacterium isolated from the faeces of Mandrillus sphinx - Qiong Wang; Xiu-Lin Han; Zhi-Qin Fang; Chen-Lu Zhang; Chun Li; Tao Lu (Antonie van Leeuwenhoek, 2022)

Applicability and improvement of different evapotranspiration methods of reference crops in Jiangxi Province - Xianghui Lu; Haina Zhang; Yixiu Han; Hua Bai; Erhui Li (Theoretical and Applied Climatology, 2022)

Study on the mechanism of Salvia miltiorrhiza polysaccharides in relieving liver injury of broilers induced by florfenicol - Yumeng Geng; Chunyu Lu; Guozhong Jin; Shuying Li; Yuqing Cui; Chao Han; Wanyu Shi; Yongzhan Bao (Environmental Science and Pollution Research, 2022)

Characterization of a strong constitutive promoter from paper mulberry vein banding virus - William K. Smith; Yu Ma; Jing Yu; Yong-Yuan Cheng; Peng Zhang; Tao-Tao Han; Quan-You Lu (Archives of Virology, 2022)

Geochemical characteristics and origin of Chang-9 crude oil of Triassic Yanchang Formation in Zhidan area, Ordos Basin, China - Zhengyu Wu; Shijia Chen; Chengshan Li; Jian Yu; Yibo Chang; Zixing Lu; Xin He; Haifeng Zhang; Han Meimei (Arabian Journal of Geosciences, 2022)

Overview of the Processes Driving Exchange at Cape Hatteras Program - Harvey Seim; Dana Savidge; Magdalena Andres; John Bane; Catherine Edwards; Glen Gawarkiewicz; Ruoying He; Robert Todd; Michael Muglia; Joseph Zambon; Lu Han; Shun Mao (Oceanography, 2022)
The Processes driving Exchange At Cape Hatteras (PEACH) program seeks to better understand seawater exchanges between the continental shelf and the open ocean near Cape Hatteras, North Carolina. This location is where the Gulf Stream transitions from a boundary-trapped current to a free jet, and where robust along-shelf convergence brings cool, relatively fresh Middle Atlantic Bight and warm, salty South Atlantic Bight shelf waters together, forming an important and dynamic biogeographic boundary. The magnitude of this convergence implies large export of shelf water to the open ocean here. Background on the oceanography of the region provides motivation for the study and gives context for the measurements that were made. Science questions focus on the roles that wind forcing, Gulf Stream forcing, and lateral density gradients play in driving exchange. PEACH observational efforts include a variety of fixed and mobile observing platforms, and PEACH modeling included two different resolutions and data assimilation schemes. Findings to date on mean circulation, the nature of export from the southern Middle Atlantic Bight shelf, Gulf Stream variability, and position variability of the Hatteras Front are summarized, together with a look ahead to forthcoming analyses.

Intensification of Downslope Nutrient Transport and Associated Biological Responses Over the Northeastern South China Sea During Wind-Driven Downwelling: A Modeling Study - Aiqin Han; Jianping Gan; Minhan Dai; Zhongming Lu; Linlin Liang; Xiaozheng Zhao (Frontiers in Marine Science, 2021)
Coastal downwelling is generally considered to have a limited biological effect compared with coastal upwelling. In this study, downslope transport of nearshore, nutrient-enriched waters during downwelling is found to induce distinct biological productivity in the water column over the northeastern South China Sea (NSCS). By conducting a process-driven study over a widened shelf with intensified downwelling in the NSCS, we investigated the biophysical processes associated with strong nutrient enrichment in the water column of downwelled waters. These processes and underlying mechanisms are largely unreported and remain unclear. Field measurements and a three-dimensional coupled physical-biological model incorporating nitrate ( N ), phytoplankton ( P ), zooplankton ( Z ), and detritus ( D ) were utilized to investigate distinct cross-shore nutrient transport over the uniquely widened NSCS shelf. We revealed that intensified downwelling circulation, dynamically induced by the widened shelf topography, enhanced chlorophyll a and biological productivity in a strip of well-mixed water over the inner shelf as well as in the downwelled water over the mid-shelf. Strong time lags and spatial differences existed among N , P , and Z because of the physical transport and the ensuing biogeochemical response. The intensified downslope transport of nutrient-rich coastal water formed distinct cross-shore wedge-shaped P , Z , and D structures, while N was rapidly consumed in the water column. This study illustrates the underlying coupled physical-biogeochemical processes associated with the observed biogeochemical response to wind-driven downwelling circulation over the variable shelf, which are commonly found in coastal oceans worldwide.

Kinetics and Size Effects on Adsorption of Cu(II), Cr(III), and Pb(II) Onto Polyethylene, Polypropylene, and Polyethylene Terephthalate Microplastic Particles - Xiaoxin Han; Shiyu Wang; Xue Yu; Rolf D. Vogt; Jianfeng Feng; Lifang Zhai; Weiqi Ma; Lin Zhu; Xueqiang Lu (Frontiers in Marine Science, 2021)
Due to its small size, large specific surface area and hydrophobicity, microplastics, and the adsorbed contaminants may together cause potential negative effects on ecosystems and human beings. In this study, kinetics and size effects on adsorption of Cu(II), Cr(III), and Pb(II) onto PE, PP and PET microplastic particles were explored. Results indicated that the PE and PET microplastics have the higher adsorption capacity for Cu(II), Cr(III), and Pb(II) than that for PP microplastic. The adsorption capacity was affected by microplastic types and metal species. Among the three metals, Pb(II) had the largest adsorption amount on microplastic particles, especially on PET particles. Moreover, the adsorption capacities of microplastics increase with the decrease of particle size. The metal adsorption capacity of <0.9 mm microplastics is greater than that of 0.9–2 mm and 2–5 mm microplastics. The size effect on metal adsorption was largest for PE microplastic. More attention should be paid in case of the coexistence of heavy metals and tiny PE and PET microplastics in the environment.

Examination of Cd Accumulation Within Sunflowers Enhanced by Low Molecular Weight Organic Acids in Alkaline Soil Utilizing an Improved Freundlich Model - Hongfei Lu; Yuru Huang; Dongmei Qiao; Yang Han; Yulong Zhao; Fangfang Bai (Journal of Soil Science and Plant Nutrition, 2021)

Correction to: What are the dominant influencing factors on the soil erosion evolution process in the Yellow River Basin? - Hongwei Wu; Bing Guo; Haorun Xue; Wenqian Zang; Baomin Han; Fei Yang; Yuefeng Lu; Cuixia Wei (Earth Science Informatics, 2021)

What are the dominant influencing factors on the soil erosion evolution process in the Yellow River Basin? - Hongwei Wu; Bing Guo; Haorun Xue; Wenqian Zang; Baomin Han; Fei Yang; Yuefeng Lu; Cuixia Wei (Earth Science Informatics, 2021)

Abdominal Massage Alleviates Skeletal Muscle Insulin Resistance by Regulating the AMPK/SIRT1/PGC-1α Signaling Pathway - Yiran Han; Zeyuan Lu; Shaotao Chen; Chongwen Zhong; Minghui Yan; Heran Wang; Meng Meng; Mingjun Liu (Cell Biochemistry and Biophysics, 2021)
Abdominal massage (AM), a traditional Chinese medicine-based treatment method, has received considerable attention in the recent years. The aim of the present study was to investigate the effect of AM on high-fat diet (HFD)-induced insulin resistance (IR) in comparison with resveratrol (RSV) treatment. Forty-eight male Sprague-Dawley rats were randomly divided into the following four groups: standard chow diet (control group), high-fat diet (model group), HFD + abdominal massage (AM group), and HFD + resveratrol (RSV group). A rat model of IR was established by feeding HFD to rats for 8 weeks followed by treatment with AM or RSV for 4 weeks. The underlying HFD-induced IR molecular mechanisms were studied in rat serum and skeletal muscles. RSV and AM significantly improved glucose intolerance, hyperglycemia, obesity, and significantly reduced lipid accumulation [triglyceride (TC), total cholesterol (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C)], adipocytokine [free fatty acids (FFA), adiponectin (ADPN)] and serum pro-inflammatory cytokines (IL-6 and TNF-α) secretion. In addition, AM activated the AMPK/SIRT1 signaling pathway in rat skeletal muscle. In conclusion, our results showed that AM could improve IR by regulating the secretion of adipocytokines, pro-inflammatory cytokines as well as related signaling pathways in the skeletal muscle of rats, which might provide insights into development of new treatment methods for the clinical treatment of IR.

Complete genome sequence of a putative novel ilarvirus isolated from Eleocharis dulcis - Lanqing Lv; Xinyang Wu; Jiajia Weng; Yuchao Lai; Kelei Han; Yuwen Lu; Jiejun Peng; Lin Lin; Shaofei Rao; Guanwei Wu; Jianping Chen; Hongying Zheng; et al. (Archives of Virology, 2021)

Effects of Dietary Inclusion of Clostridium autoethanogenum Protein on the Growth Performance and Liver Health of Largemouth Bass (Micropterus salmoides) - Qisheng Lu; Longwei Xi; Yulong Liu; Yulong Gong; Jingzhi Su; Dong Han; Yunxia Yang; Junyan Jin; Haokun Liu; Xiaoming Zhu; Shouqi Xie (Frontiers in Marine Science, 2021)
Clostridium autoethanogenum protein (CAP) is a novel protein source for aqua-feeds. The present study aimed to investigate the effects of dietary CAP on growth performance, immunity, and liver health status of juvenile largemouth bass ( Micropterus salmoides ). Four isonitrogenous and isolipid experimental diets were formulated to replace 0% (D1, control), 25% (D2), 50% (D3), and 75% (D4) of fish meal by CAP. Fish (15.05 ± 0.08 g) were randomly fed one of four experimental diets for 8 weeks. The results showed that weight gain (WG), specific growth rate (SGR), feeding rate (FR), viscerosomatic index (VSI), and hepatosomatic index (HSI) of the D4 group were significantly lower than D1, D2, and D3 groups ( P < 0.05). With the increase of substitution level, the total antioxidant capacity (T-AOC) of liver tissue was significantly decreased, while the plasma alkaline phosphatase (AKP) activity was significantly increased ( P < 0.05). Plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were significantly higher in D3 and D4 groups than in D1 and D2 groups ( P < 0.05). Replacing 50 or 75% fish meal by CAP significantly induced the transcription level of apoptosis-promoting genes ( bcl-2 -associated death protein [ bad ] and bcl-2 -assoxicated × protein; bag [ bax ]), anti-apoptosis-related genes (tumor protein 53 [p53 ] and b-cell lymphoma-2 [ bcl-2 ]), and the apoptotic Caenorhabditis elegans ( C. elegans ) death gene-3 like caspases (cysteine-aspartic proteases-3 [ caspase-3 ], cysteine-aspartic proteases-8 [ caspase-8 ], cysteine-aspartic proteases-9 [ caspase-9 ], and cysteine-aspartic proteases-10 [ caspase-10 ]) in liver, while suppressed the gene expression of the inflammatory factors [interleukin-1β ( il-1 β), interleukin-8 ( il-8 ), and tumor necrosis factor, tnf ] in head kidney. At the same time, dietary inclusion of CAP elevated the protein expression of bcl-2, autophagy microtubule-associated protein light chain 3A/B (LC3A/B-I), and LC3A/B-II by inhibiting the phosphorylation of the mammalian target of rapamycin (mTOR; P < 0.05). Moreover, the apoptosis rate of the D3 and D4 groups was significantly increased ( P < 0.05). Taken together, these results indicated that the optimal level of CAP-replacing fish meal should be <50% that has no negative effect on the growth performance and liver health of juvenile largemouth bass. In addition, excessive CAP inclusion may damage liver health by activating autophagy and apoptosis signaling pathways.

Three new diterpenoids from Euphorbia peplus - Yan-Ni Chen; Qing-Yun Lu; Dong-Mei Li; Ying-Yao Li; Xue-Xue Pu; Bo-Ting Li; Xiao-Han Tang; Hong-Yu Tang; Shuai Liu; Lei Yang; Yu Zhang; Ying-Tong Di; et al. (Natural Product Research, 2021)

Investigation into Polycyclic Aromatic Hydrocarbons in Sediments of Wei River Basin - Yongfeng Shi; Yuehan Lu; Yucheng Zhang; Xiaotong Su; Qihang Wu; Huifang Lei; Linchuan Fang; Fengbao Zhang; Zhineng Liu; Jie Han; Bixian Mai (Water, Air, & Soil Pollution, 2021)

Identification and fine mapping of alien fragments associated with enhanced grain weight from Agropyron cristatum chromosome 7P in common wheat backgrounds - Yangyang Sun; Mingjie Lyu; Haiming Han; Shenghui Zhou; Yuqing Lu; Weihua Liu; Xinming Yang; Xiuquan Li; Jinpeng Zhang; Xu Liu; Lihui Li (Theoretical and Applied Genetics, 2021)

TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain - Lu Wang; Han-Yu Yang; Cai-Xia Zang; Jun-Mei Shang; Hui Liu; Zi-Hong Zhang; Fang-Yu Yuan; Cheng Ju; Fang-Yuan Li; Xiu-Qi Bao; Dan Zhang (Molecular Neurobiology, 2021)

Pepsinogen C expression–related lncRNA/circRNA/mRNA profile and its co-mediated ceRNA network in gastric cancer - Li-rong Yan; Han-xi Ding; Shi-xuan Shen; Xiao-dong Lu; Yuan Yuan; Qian Xu (Functional & Integrative Genomics, 2021)

Methacrylic functionalized hybrid carbon nanomaterial for the selective adsorption and detection of progesterone in wastewater - Xia Cui; Hua Shu; Lu Wang; Guoning Chen; Jili Han; Qianqian Hu; Kamran Bashir; Zhimin Luo; Chun Chang; Jia Zhang; Qiang Fu (Environmental Science and Pollution Research, 2021)

Design and Characterization of HY-038 Solid Dispersions via Spray Drying Technology: In Vitro and In Vivo Evaluations - Taotao Jiang; Limei Han; Enhao Lu; Wenxiu He; Shilin Du; Xianyi Sha (AAPS PharmSciTech, 2021)

Increased Cu(II) Adsorption Onto UV-Aged Polyethylene, Polypropylene, and Polyethylene Terephthalate Microplastic Particles in Seawater - Xiaoxin Han; Rolf D. Vogt; Jiaying Zhou; Boyang Zheng; Xue Yu; Jianfeng Feng; Xueqiang Lu (Frontiers in Marine Science, 2021)
Environmental effects of microplastic are rather due to their adsorption capacity of contaminants than themselves. Aging is a key factor influencing adsorption properties of environmental microplastics. In order to clarify this influence, polyethylene (PE), polypropylene (PP), and polyethylene terephthalate (PET) microplastics with particle sizes of <0.9 mm, 0.9–2 mm, and 2–5 mm were artificially aged in seawater for 12 months. This enabled an assessment of the change in Cu(II) adsorption capacity to the microplastics particles under aging. According to the FTIR spectra, fresh microplastics were oxidized during the UV induced aging process. The adsorption capacities of microplastic were positively correlated with their aging time. After 12-months aging, the amount of Cu(II) adsorbed to the aged microplastics was 1.45–2.92 times higher than on the fresh microplastic particles. For PP and PET, the aging effect increased with decreasing size of the microplastic particles. In the case of PE, particles with the medium particle size (0.9–2 mm) had the strongest aging effect.

An iterative updating heuristic search strategy for groundwater contamination source identification based on an ACPSO–ELM surrogate system - Han Wang; Wenxi Lu; Zhenbo Chang (Stochastic Environmental Research and Risk Assessment, 2021)

SbCASP4 improves salt exclusion by enhancing the root apoplastic barrier - Xiaocen Wei; Lili Liu; Chaoxia Lu; Fang Yuan; Guoliang Han; Baoshan Wang (Planta, 2021)

Removal efficacy of opportunistic pathogen gene markers in drinking water supply systems: an in situ and large-scale molecular investigation - Ziming Han; Junying Lu; Wei An; Yu Zhang; Min Yang (Environmental Science and Pollution Research, 2021)

Regional brain network and behavioral alterations in EGR3 gene transfected rat model of schizophrenia - Wenwen Gao; Guangfei Li; Xiaowei Han; Zeyu Song; Shuai Zhao; Feiyi Sun; Hong Ma; Ailing Cui; Yige Wang; Xiuxiu Liu; Yue Chen; Lu Zhang; et al. (Brain Imaging and Behavior, 2021)

Optimization of oil source correlation indexes: a case of Chang 10 member in Ordos Basin’ Zhoujiawan area - Kun Xu; Shijia Chen; Yuting Hou; Zixing Lu; Chen Li; Meimei Han (Arabian Journal of Geosciences, 2021)

Incorporating Species-Conditional Co-Occurrence When Selecting Indicator Species to Monitor Restoration after Mangrove Removal from the Siangshan Wetland, Taiwan - Ta-Jen Chu; Chun-Han Shih; Yu-Ming Lu; Yi-Jia Shih; Jia-Qiao Wang; Liang-Ming Huang (Journal of Marine Science and Engineering, 2021)
This paper presents an approach for incorporating species-conditional co-occurrence into models used for the selection of marine indicator species. Mangrove invasion within the Siangshan Wetland in Hsinchu, Taiwan, has changed the original structures and functions of habitats for benthic organisms. The Hsinchu City Government ran a large-scale mangrove removal project from October 2015 to March 2016 to restore the wetland. From October 2015 to September 2016, we investigated the biological effects of mangrove removal on benthic crabs and their adjacent habitats. Density, number of species, Shannon–Weaver index (H′) and Palou’s evenness index (J′) were calculated and compared between mangrove and non-mangrove regions. The results showed that values for these attributes in the non-mangrove regions were higher than those of the mangrove regions. After mangrove removal, species returned to their original habitats and the related density increased significantly. Using conditional co-occurrence algorithms, we identified five indicator species (Mictyris brevidactylus, Macrophthalmus banzai, Uca arcuata, Uca lacteal and Uca borealis) with high co-occurrence probabilities, whose population responses provided direct evidence of the benefits of mangrove removal for wetland restoration. The results indicate that mangrove removal is an appropriate habitat rehabilitation strategy for benthic organisms, and that the chosen indicator species may provide valuable ecological information for coastal managers seeking to control the spread of mangroves.

Spatial and Seasonal Distribution of 2-Methylisoborneol in a Large Eutrophic Shallow Lake, China - Anjie Wu; Yadong Wang; Kurt Friese; Lu Zhang; Chao Han; Dejun Kang; Qiushi Shen (Water, Air, & Soil Pollution, 2021)

Efficiently immobilizing uranium (VI) by oxidized carbon foam - Hongliang Bao; Chunyu Xie; Ling Han; Zenghui Yue; Yuan Qian; Linjuan Zhang; Zi-Jian Li; Huangjie Lu; Jian Lin; Jian-Qiang Wang (Environmental Science and Pollution Research, 2021)

Retrieval and analysis of land surface temperature in permafrost regions in Northeast China based on AMSR2 data - Han Yin; Miao Li; Haoran Man; Xingfeng Dong; Boquan Lu; Shuying Zang (Earth Science Informatics, 2021)

Sphingobacterium rhinopitheci sp. Nov., isolated from the faeces of Rhinopithecus bieti in China - Xiu-Lin Han; Qiong Wang; Chen-Lu Zhang; Zhi-Qin Fang; Jian-Qiang Shen; Song Huang; Tao Lu (Archives of Microbiology, 2021)

A Deep Learning Method for Bias Correction of ECMWF 24–240 h Forecasts - Lei Han; Mingxuan Chen; Kangkai Chen; Haonan Chen; Yanbiao Zhang; Bing Lu; Linye Song; Rui Qin (Advances in Atmospheric Sciences, 2021)
Correcting the forecast bias of numerical weather prediction models is important for severe weather warnings. The refined grid forecast requires direct correction on gridded forecast products, as opposed to correcting forecast data only at individual weather stations. In this study, a deep learning method called CU-net is proposed to correct the gridded forecasts of four weather variables from the European Centre for Medium-Range Weather Forecast Integrated Forecasting System global model (ECMWF-IFS): 2-m temperature, 2-m relative humidity, 10-m wind speed, and 10-m wind direction, with a forecast lead time of 24 h to 240 h in North China. First, the forecast correction problem is transformed into an image-to-image translation problem in deep learning under the CU-net architecture, which is based on convolutional neural networks. Second, the ECMWF-IFS forecasts and ECMWF reanalysis data (ERA5) from 2005 to 2018 are used as training, validation, and testing datasets. The predictors and labels (ground truth) of the model are created using the ECMWF-IFS and ERA5, respectively. Finally, the correction performance of CU-net is compared with a conventional method, anomaly numerical correction with observations (ANO). Results show that forecasts from CU-net have lower root mean square error, bias, mean absolute error, and higher correlation coefficient than those from ANO for all forecast lead times from 24 h to 240 h. CU-net improves upon the ECMWF-IFS forecast for all four weather variables in terms of the above evaluation metrics, whereas ANO improves upon ECMWF-IFS performance only for 2-m temperature and relative humidity. For the correction of the 10-m wind direction forecast, which is often difficult to achieve, CU-net also improves the correction performance.

The protective effect of hydrogen-rich water on rats with type 2 diabetes mellitus - Mengna Zheng; Han Yu; Yong Xue; Tong Yang; Qiufen Tu; Kaiqing Xiong; Daihua Deng; Lei Lu; Nan Huang (Molecular and Cellular Biochemistry, 2021)

Activation of autophagy reverses gemcitabine-induced immune inhibition of RAW264.7 macrophages by promoting TNF-α, IL-6 and MHC-II expression - Shanshan Jiang; Rong Wang; Lu Han; Kudelaidi Kuerban; Li Ye; Shu Pan; Shengnan Li; Yongfang Yuan (Immunologic Research, 2021)
This research aims to investigate the effect of gemcitabine (GEM) on various activities and functions of macrophages. Phagocytosis, cell autophagy and reactive oxygen species (ROS) were analysed by laser scanning confocal microscope. The cell cycle status and major histocompatibility complex II (MHC-II) expression were examined by flow cytometry. Inflammatory cytokine secretion such as tumour necrosis factor α (TNF-α) and interleukin 6 (IL-6) was detected by Elisa assay. The expression of proteins was analysed by western blot method. The results revealed that GEM-induced immune inhibition of M1-type RAW264.7 macrophages activated by interferon-γ (IFN-γ) and lipopolysaccharide (LPS). We also found that GEM inhibited autophagy, as evidenced by the reduced formation of autophagosome-like vacuoles and autophagosomes. Further study showed that incubation of activated macrophages with the autophagy inhibitor 3-MA induced immune suppression. In contrast, treatment with the autophagy inducer trehalose (Tre) restored phagocytosis, TNF-α and IL-6 secretion, and MHC-II expression in GEM-induced immune-inhibited macrophages. GEM reduced immune effect of M1-type RAW264.7 macrophages via inhibiting TNF-α, IL-6 and MHC-II expression. Furthermore, activation of autophagy by Tre reversed GEM-induced immune inhibition of RAW264.7 macrophages.

Coxsackievirus B4: an underestimated pathogen associated with a hand, foot, and mouth disease outbreak - Jinbo Xiao; Jianxing Wang; Yong Zhang; Dapeng Sun; Huanhuan Lu; Zhenzhi Han; Yang Song; Dongmei Yan; Shuangli Zhu; Yaowen Pei; Wenbo Xu; Xianjun Wang (Archives of Virology, 2021)

Cloud-Based Multidimensional Parallel Dynamic Programming Algorithm for a Cascade Hydropower System - Yufei Ma; Ping-an Zhong; Bin Xu; Feilin Zhu; Jieyu Li; Han Wang; Qingwen Lu (Water Resources Management, 2021)

Quantitative Fluorescence Resonance Energy Transfer Analysis on the Direct Interaction of Activation-2b with Histone H3/Switch-3B Protein in Arabidopsis Mesophyll Protoplasts - Lu Gao; Fangrui Lin; Danlu Han; Jieming Jiang; Chengwei Yang; Zhengfei Zhuang; Tongsheng Chen (Journal of Fluorescence, 2021)

Simultaneous identification of groundwater contamination source and aquifer parameters with a new weighted–average wavelet variable–threshold denoising method - Han Wang; Wenxi Lu; Zhenbo Chang (Environmental Science and Pollution Research, 2021)

LINC00943 knockdown exerts neuroprotective effects in Parkinson’s disease through regulates CXCL12 expression by sponging miR-7-5p - Han Lian; Baohua Wang; Quan Lu; Bin Chen; Hui Yang (Genes & Genomics, 2021)

Establishment of an indirect ELISA-based method involving the use of a multiepitope recombinant S protein to detect antibodies against canine coronavirus - Yun-Feng Hao; Shao-Han Li; Guang-Zhi Zhang; Yi Xu; Guang-zong Long; Xiao-xiong Lu; Shang-Jin Cui; Tong Qin (Archives of Virology, 2021)

Genetic Architecture of Childhood Kidney and Urological Diseases in China - Ye Fang; Hua Shi; Tianchao Xiang; Jiaojiao Liu; Jialu Liu; Xiaoshan Tang; Xiaoyan Fang; Jing Chen; Yihui Zhai; Qian Shen; Guomin Li; Li Sun; et al. (Phenomics, 2021)
Kidney disease is manifested in a wide variety of phenotypes, many of which have an important hereditary component. To delineate the genotypic and phenotypic spectrum of pediatric nephropathy, a multicenter registration system is being implemented based on the Chinese Children Genetic Kidney Disease Database (CCGKDD). In this study, all the patients with kidney and urological diseases were recruited from 2014 to 2020. Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features. The genetic diagnosis was confirmed in 883 of 2256 (39.1%) patients from 23 provinces in China. Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome (SRNS, 23.5%), glomerulonephritis (GN, 32.2%), congenital anomalies of the kidney and urinary tract (CAKUT, 21.2%), cystic renal disease (3.9%), renal calcinosis/stone (3.6%), tubulopathy (9.7%), and chronic kidney disease of unknown etiology (CKDu, 5.8%). The pathogenic variants of 105 monogenetic disorders were identified. Ten distinct genomic disorders were identified as pathogenic copy number variants (CNVs) in 11 patients. The diagnostic yield differed by subgroups, and was highest in those with cystic renal disease (66.3%), followed by tubulopathy (58.4%), GN (57.7%), CKDu (43.5%), SRNS (29.2%), renal calcinosis /stone (29.3%) and CAKUT (8.6%). Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions. We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed. Our data demonstrate the utility of family-based exome sequencing, and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease.

Different posterior hippocampus and default mode network modulation in young APOE ε4 carriers: a functional connectome-informed phenotype longitudinal study - Li Juan Zheng; Li Lin; U. Joseph Schoepf; Akos Varga-Szemes; Rock H. Savage; Han Zhang; Yun Fei Wang; Xin Yuan Zhang; Song Luo; Ya Liu; Gui Fen Yang; Guang Ming Lu; et al. (Molecular Neurobiology, 2021)

The Knowledge and Attitude Towards Advance Care Planning Among Chinese Patients with Advanced Cancer - Xiao-Ting Hou; Yu-Han Lu; Hong Yang; Ren-Xiu Guo; Yun Wang; Li-Hong Wen; Ya-Ru Zhang; Hong-Yu Sun (Journal of Cancer Education, 2021)

Paleoclimatic proxies from global closed basins and the possible beginning of Anthropocene - Yu Li; Qin Han; Lu Hao; Xinzhong Zhang; Dawei Chen; Yuxin Zhang; Lingmei Xu; Wangting Ye; Simin Peng; Yichan Li; Zhuowen Feng; Hebin Liu (Journal of Geographical Sciences, 2021)

Precise frequency transfer model suitable for short baseline link based on GPS single-differenced observations with ambiguity resolution - Rui Tu; Pengfei Zhang; Rui Zhang; Lihong Fan; Junqiang Han; Ju Hong; Jinhai Liu; Xiaochun Lu (Acta Geodaetica et Geophysica, 2021)

Resolvin D1 Attenuates Innate Immune Reactions in Experimental Subarachnoid Hemorrhage Rat Model - Guang-Jie Liu; Tao Tao; Xiang-Sheng Zhang; Yue Lu; Ling-Yun Wu; Yong-Yue Gao; Han Wang; Hai-Bin Dai; Yan Zhou; Zong Zhuang; Chun-Hua Hang; Wei Li (Molecular Neurobiology, 2021)

Puerhibacterium puerhi gen. nov., sp. nov., a novel member of the family Promicromonosporaceae, isolated from Pu-erh tea pile-fermentation - Rui-Juan Yang; De Zhou; Qiao-Mei Wang; Lu Han; Wen-Shu Peng; Li Liu; Xuan-Jun Wang; Liang Yan; Jie Lv; Jun Sheng (Archives of Microbiology, 2021)

Recognizing groundwater DNAPL contaminant source and aquifer parameters using parallel heuristic search strategy based on Bayesian approach - Han Wang; Wenxi Lu (Stochastic Environmental Research and Risk Assessment, 2021)

Exendin-4 Reversed the PC12 Cell Damage Induced by circRNA CDR1as/miR-671/GSK3β Signaling Pathway - Hui Quan; Qiudan Chen; Kesheng Wang; Qinwan Wang; Meiling Lu; Yue Zhang; Sujing Qiang; Shaobo Xue; Lin Han; Huanhuan Zhu; Qiangyuan Fan; Meiyu Bao; et al. (Journal of Molecular Neuroscience, 2021)

New secondary metabolite with cytotoxicity from spawning soft coral Asterospicularia laurae in Taiwan - Jui-Hsin Su; Chih-I Liu; Mei-Chin Lu; Chi-I Chang; Min-Ying Hsieh; Yu-Chi Lin; Chang-Feng Dai; Ya-Han Zhang; Zheng-Yu Lin; Yun-Sheng Lin (Natural Product Research, 2021)

Surrogate-Based Stochastic Multiobjective Optimization for Coastal Aquifer Management under Parameter Uncertainty - Zheng Han; Wenxi Lu; Yue Fan; Jianan Xu; Jin Lin (Water Resources Management, 2021)

At3g53630 encodes a GUN1-interacting protein under norflurazon treatment - Xing-Qi Huang; Lin-Juan Wang; Meng-Juan Kong; Na Huang; Xin-Ya Liu; Han-Yu Liang; Jia-Xin Zhang; Shan Lu (Protoplasma, 2021)

Differences in the fecal microbiota due to the sexual niche segregation of captive Gentoo penguins Pygoscelis papua - Jiashen Tian; Jing Du; Zhichuang Lu; Yanqiu Li; Duohui Li; Jiabo Han; Zhen Wang; Xiaoyan Guan (Polar Biology, 2021)

Prevalence of Depression or Depressive Symptoms in Patients with Narcolepsy: a Systematic Review and Meta-Analysis - Xiao Li; Larry D. Sanford; Qiang Zong; Ye Zhang; Lu Tan; Taomei Li; Rong Ren; Junying Zhou; Fang Han; Xiangdong Tang (Neuropsychology Review, 2021)

Downregulated hypoxia-inducible factor 1α improves myoblast differentiation under hypoxic condition in mouse genioglossus - Yun Lu; Jiaqi Mao; Xinxin Han; Weihua Zhang; Yuanyuan Li; Yuehua Liu; Qiang Li (Molecular and Cellular Biochemistry, 2021)

Tyrosine kinase Fyn promotes apoptosis after intracerebral hemorrhage in rats by activating Drp1 signaling - Li Zhang; Lu Wang; Han Xiao; Hui Gan; Hui Chen; Shuyue Zheng; Dan Jian; Xuan Zhai; Ning Jiang; Zhao Jing; Ping Liang (Journal of Molecular Medicine, 2021)

Ultra-Fast Computation of Excited-States Spectra for Large Systems: Ultraviolet and Fluorescence Spectra of Proteins - Yonggang Liu; Jianjie Xu; Li Han; Qiangqiang Liu; Yunfan Yang; Zeren Li; Zhongyuan Lu; Hang Zhang; Tengxiao Guo; Qiao Liu (Interdisciplinary Sciences: Computational Life Sciences, 2021)

Simultaneous identification of groundwater contaminant sources and simulation of model parameters based on an improved single-component adaptive Metropolis algorithm - Zhenbo Chang; Wenxi Lu; Han Wang; Jiuhui Li; Jiannan Luo (Hydrogeology Journal, 2021)

Decontamination performance and cleaning characteristics of three common used paved permeable bricks - Suhua Han; Ye Yang; Shuang Liu; Minbo Lu (Environmental Science and Pollution Research, 2021)

Dietary Serine and Sulfate-Containing Amino Acids Related to the Nutritional Status of Selenium in Lactating Chinese Women - Feng Han; Xuehong Pang; Qin Wang; Yiqun Liu; Liping Liu; Yingjuan Chai; Jie Zhang; Shijin Wang; Jiaxi Lu; Licui Sun; Shuo Zhan; Hongying Wu; et al. (Biological Trace Element Research, 2021)

New 23, 27-dihydroxy-oleanane-type triterpenoid saponins from Anemone Raddeana Regel - Chongning Lv; Ying Zhao; Bin Zhao; Ling Han; Jincai Lu (Natural Product Research, 2021)

Transcriptional and post-transcriptional regulation of the miR171-LaSCL6 module during somatic embryogenesis in Larix kaempferi - Qiao-Lu Zang; Yao Zhang; Su-Ying Han; Wan-Feng Li; Li-Wang Qi (Trees, 2021)
Key message Expression analysis of Larix kaempferi mature miR171s and their primary transcripts and target gene LaSCL6 during somatic embryogenesis revealed the transcriptional and post-transcriptional regulation of the miR171- LaSCL6 module. Abstract Somatic embryogenesis provides a useful experimental system for studying the regulatory mechanisms of plant development. The level and activity of microRNA171 (miR171) fluctuate during somatic embryogenesis in Larix kaempferi , but the underlying mechanisms are still unclear. Here, in L. kaempferi we identified five members of the miR171 family, which cleave LaSCL6 mRNA at different sites. In addition, we improved the method of measuring miRNA activity in a more direct way. Furthermore, we measured the expression patterns of mature miR171s and their primary transcripts during somatic embryogenesis in L. kaempferi and found that their patterns differed, indicating that the transcription of MIR171 genes and the subsequent cleavage of their intermediate products are regulated. Taken together, our findings not only offer a means to study the regulation of miRNA activity, but also provide further insight into the regulation of L . kaempferi somatic embryogenesis by miR171- LaSCL6 .

The adaptability of typical precipitation ensemble prediction systems in the Huaihe River basin, China - Han Wang; Ping-an Zhong; Fei-lin Zhu; Qing-wen Lu; Yu-fei Ma; Sun-yu Xu (Stochastic Environmental Research and Risk Assessment, 2021)

A candidate PpRPH gene of the D locus controlling fruit acidity in peach - Lu Wang; Xiaohan Jiang; Li Zhao; Furong Wang; Yudi Liu; Hui Zhou; Huaping He; Yuepeng Han (Plant Molecular Biology, 2021)

The circular RNAs differential expression profiles in the metastasis of salivary adenoid cystic carcinoma cells - Rui Ju; Yanling Huang; Zeyou Guo; Lu Han; Suhui Ji; Luyang Zhao; Jie Long (Molecular and Cellular Biochemistry, 2021)

The application of an absorbent-amended microalgal-bacterial system for enhancing hydrothermal liquefaction wastewater treatment and resource recovery - Ting Han; Mengzi Wang; Haifeng Lu; Yuanhui Zhang; Guangming Zhang; Baoming Li; Wei Cao (Journal of Applied Phycology, 2021)

Association between selected urinary heavy metals and asthma in adults: a retrospective cross-sectional study of the US National Health and Nutrition Examination Survey - Xiuzhu Li; Yun Fan; Yan Zhang; Xiaomin Huang; Zhenyao Huang; Mingming Yu; Qiaoqiao Xu; Xiumei Han; Chuncheng Lu; Xinru Wang (Environmental Science and Pollution Research, 2021)

Spatial variation in macrobenthic assemblages and their relationship with environmental factors in the upstream and midstream regions of the Heihe River Basin, China - Yu Wang; Juan-Juan Liu; Wei Liu; Qi Feng; Bao-long Li; Han Lu; Shuang Wang (Environmental Monitoring and Assessment, 2021)
The Heihe River is a typical inland river under increasing anthropogenic pressure. To explore the characteristics of the macrobenthic assemblages and their relationships with environmental factors in the upstream and midstream regions of this basin, abiotic conditions and macrobenthic assemblages were investigated in the summers of 2018 and 2019. A total of 50 species were collected, and Arthropoda and mollusks were the dominant groups. A significant increase in standing stock was observed from the upstream to midstream, and predators (PR) were the main functional feeding group. A one-way analysis of variance (ANOVA) revealed that the Shannon-Wiener index and Margalef’s index values significantly differed at the spatial scale ( P < 0.05). A redundancy analysis (RDA) and Pearson correlation analysis showed that the spatial heterogeneity of the macrobenthos was influenced by the biochemical oxygen demand (BOD 5 ), water temperature (WT), total nitrogen (TN), salinity, electrical conductivity (EC), total dissolved solids (TDS), dissolved oxygen (DO), and potassium permanganate index (COD Mn ) ( P < 0.05). The spatial variation of macrobenthos was mainly governed by natural conditions and human disturbances.

Influence of the Micro-deformation Characteristics of Binary Media on the Shear Behavior of Structural Plane - Hang Lin; Lu Han; Yixian Wang; Rihong Cao; Yanlin Zhao; Chong Jiang (Geotechnical and Geological Engineering, 2021)

MiRNA-seq analysis of spleen and head kidney tissue from aquacultured largemouth bass (Micropterus salmoides) in response to Aeromonas hydrophila infection - Jian Zhou; Han Zhao; Lu Zhang; Qiang Li; Zhipeng Huang; Zhongmeng Zhao; Hongyu Ke; Yu Xiao; Xutao Su; Qiao Liu; Song Yang; Liulan Zhao (Functional & Integrative Genomics, 2021)

Complete genome sequence of a new achyranthes virus A isolate from Achyranthes bidentata in China - Xinyang Wu; Yuchao Lai; Lanqing Lv; Kelei Han; Ziqiang Chen; Yuwen Lu; Jiejun Peng; Lin Lin; Jianping Chen; Hongying Zheng; Fei Yan (Archives of Virology, 2021)

A new cyclic peptide from the fibrous root of Pseudostellaria heterophylla - Xiao-fei Zhao; Qian Zhang; Han-tao Zhao; Yan-da Zhang; Han-ru Liu; Lu-jiang Yuan; Qian-feng Chen (Natural Product Research, 2020)

Fucoxanthin Mitigates Subarachnoid Hemorrhage-Induced Oxidative Damage via Sirtuin 1-Dependent Pathway - Xiang-Sheng Zhang; Yue Lu; Tao Tao; Han Wang; Guang-Jie Liu; Xun-Zhi Liu; Cang Liu; Da-Yong Xia; Chun-Hua Hang; Wei Li (Molecular Neurobiology, 2020)

Assessing SARS-CoV-2 RNA levels and lymphocyte/T cell counts in COVID-19 patients revealed initial immune status as a major determinant of disease severity - Mingfeng Han; Mengyuan Xu; Yafei Zhang; Zhongping Liu; Shasha Li; Tengfei He; Jinsong Li; Yong Gao; Wanjun Liu; Tuantuan Li; Zixiang Chen; Xin Huang; et al. (Medical Microbiology and Immunology, 2020)

Resveratrol protects H9c2 cells against hypoxia-induced apoptosis through miR-30d-5p/SIRT1/NF-κB axis - Xia Han; Lu Zhang; Yingcai Liu; Menghai Wu; Xingchao Li; Zeng Tang Zhang; Tao Li (Journal of Biosciences, 2020)

Theoretical Research on Excited States: Ultraviolet and Fluorescence Spectra of Aromatic Amino Acids - Yonggang Liu; Jianjie Xu; Li Han; Qiangqiang Liu; Yunfan Yang; Zeren Li; Zhongyuan Lu; Hang Zhang; Tengxiao Guo; Qiao Liu (Interdisciplinary Sciences: Computational Life Sciences, 2020)

Update on recommendations for the diagnosis and treatment of SARS-CoV-2 infection in children - Hongjun Miao; Han Li; Yinying Yao; Mingfu Wu; Chao Lu; Jun Wang; Man Tian; Ying Li; Peiliang Luo; Jianhui Gu; Bin Yuan; Shouchuan Wang; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2020)
Since the outbreak of novel coronavirus infection pneumonia in Wuhan City, China, in late 2019, such cases have been gradually reported in other parts of China and abroad. Children have become susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) because of their immature immune function. As the outbreak has progressed, more cases of novel coronavirus infection/pneumonia in children have been reported. Compared with adults, the impact of SARS-CoV-2 infection in children is less severe, with a lower incidence and susceptibility in children, which results in fewer children being tested, thereby underestimating the actual number of infections. Therefore, strengthening the diagnosis of the disease is particularly important for children, and early and clear diagnosis can determine treatment strategies and reduce the harm caused by the disease to children. According to the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards ( trial version 7 ) issued by National Health Committee and the latest diagnosis and treatment strategies for novel coronavirus infection pneumonia in children, this review summarizes current strategies on diagnosis and treatment of SARS-CoV-2 infection in children.

Dietary exposure assessment of cadmium, arsenic, and lead in market rice from Sri Lanka - Lin Liu; Jialiang Han; Xiaohang Xu; Zhidong Xu; Kasun S. Abeysinghe; Anjana J. Atapattu; P. Mangala C. S. De Silva; Qinhui Lu; Guangle Qiu (Environmental Science and Pollution Research, 2020)

Gut dysbiosis-influence on amygdala-based functional activity in patients with end stage renal disease: a preliminary study - Li Juan Zheng; Li Lin; Jianhui Zhong; Zhihong Zhang; Yu Bing Ye; Xin Yuan Zhang; Yun Fei Wang; Han Zhang; Ya Liu; Guang Ming Lu; Dehua Gong; Long Jiang Zhang (Brain Imaging and Behavior, 2020)

Frequency-dependent changes in fractional amplitude of low-frequency oscillations in Alzheimer’s disease: a resting-state fMRI study - Liu Yang; Yan Yan; Yuxia Li; Xiaochen Hu; Jie Lu; Piu Chan; Tianyi Yan; Ying Han (Brain Imaging and Behavior, 2020)

Updating and identifying three novel variants of the CARD14 gene in Chinese Han patients with psoriasis - Yike Huang; Chenhui Zhang; Lu Tao; Jiaqing Zhou; Jie Zhu; Kexiang Yan; Ling Han; Qiong Huang; Jinxiu Shi; Zhenghua Zhang (Journal of Genetics, 2020)

Study of the geostatistical grid maths operation method of quantifying water movement in soil layers of a cotton field * - Liyuan Liu; Fangfang Xing; Yabing Li; Yingchun Han; Zhanbiao Wang; Xiaoyu Zhi; Guoping Wang; Lu Feng; Beifang Yang; Yaping Lei; Zhengyi Fan; Wenli Du (Irrigation and Drainage, 2020)
The precise quantification of water movement in different field soil layers is important for variable‐rate irrigation and fertilization. To this end, a field experiment based on a geostatistical approach was conducted in southern Anyang, Henan, China, to examine soil water movement in a cotton field with drip irrigation by measuring the soil water content (SWC) data on a regular 100 × 80 cm grid. The result shows that the temporal and spatial variation of soil moisture decreased with the increase of soil depth at different points, and apparent spatial heterogeneity was observed under different soil conditions through a semivariogram analysis. The variation of soil moisture at different soil profiles was affected by the cotton plants and drip lines in non‐irrigation and irrigation periods respectively. The level of the change at 20 cm was more than 70 cm in the horizontal direction in the two periods, however the degree of change at 40 cm in the irrigation period was more than 70 cm in the vertical direction, while contrary results were shown in the non‐irrigation period. Moreover, the results indicated that the trapezoidal rule could be applied to quantify the volume of water movement precisely.

Petrogenesis of post-collisional magmatism at the Carboniferous–Permian boundary in central Inner Mongolia, NE China: insights into when the Hegenshan Ocean closed? - Lu Lu; Yong Qin; Kai-Jun Zhang; Chun-Yuan Han; Zhuang-Fu Li; Tao Wei; Zheng-Hui Qu; Yong-Zhong Xu (International Geology Review, 2020)

Characterization of a Protease Hyper-Productive Mutant of Bacillus pumilus by Comparative Genomic and Transcriptomic Analysis - Yong-Cheng Liu; Lin-Li Han; Tian-Yu Chen; Yan-Bing Lu; Hong Feng (Current Microbiology, 2020)

Development and Evaluation of Astaxanthin as Nanostructure Lipid Carriers in Topical Delivery - Qiang Geng; Yuming Zhao; Lu Wang; Lulu Xu; Xiong Chen; Jing Han (AAPS PharmSciTech, 2020)

Effects of Drying-Rewetting Frequency on Vertical and Lateral Loss of Soil Organic Carbon in a Tidal Salt Marsh - Juanyong Li; Wendi Qu; Guangxuan Han; Feng Lu; Yingfeng Zhou; Weimin Song; Baohua Xie; Franziska Eller (Wetlands, 2020)

Effects of Hydrological Connectivity on Snail Assemblages in the Intertidal Zone of Coastal Wetlands - Haitao Wu; Qiang Guan; Kangle Lu; Guangxuan Han; Baoquan Li; Mengyao Yang (Wetlands, 2020)

Risk analysis of reservoir floodwater utilization coupling meteorological and hydrological uncertainties - Qingwen Lu; Ping-an Zhong; Bin Xu; Feilin Zhu; Han Wang; Yufei Ma (Stochastic Environmental Research and Risk Assessment, 2020)

The combinatory effects of natural products and chemotherapy drugs and their mechanisms in breast cancer treatment - Yubo Zhang; Huajun Li; Jing Zhang; Chaoran Zhao; Shuai Lu; Jinping Qiao; Mei Han (Phytochemistry Reviews, 2020)

Exploring slope spatial heterogeneity by nitrogen transfer and arbuscular mycorrhizal community - Yanyan Yu; Lu Zhao; Min Cui; Yutong Xiao; Cong Wang; Yuan Miao; Zhijie Chen; Yanhong Cao; Junqiang Zheng; Shijie Han (Journal of Soils and Sediments, 2020)

Parallel heuristic search strategy based on a Bayesian approach for simultaneous recognition of contaminant sources and aquifer parameters at DNAPL-contaminated sites - Wenxi Lu; Han Wang; Jiuhui Li (Environmental Science and Pollution Research, 2020)

Transcriptome Analysis of the Acid Stress Response of Desulfovibrio vulgaris ATCC 7757 - Hang Yu; Zhiqiang Jiang; Yueer Lu; Xurong Yao; Chongyin Han; Ying Ouyang; Han Wang; Chuling Guo; Fei Ling; Zhi Dang (Current Microbiology, 2020)