Synergistic effect of F doping and WO3 loading on electrocatalytic oxygen evolution - Ke Lu; Zongyuan Wang; Yaoxin Wu; Xingwu Zhai; Chenxu Wang; Ju Li; Zhimou Wang; Xinyi Li; Yuxuan He; Ting An; Kun Yang; Dezheng Yang; et al. (Chemical Engineering Journal, 2023)

Optimal design and experimental study of horn antenna in pavement microwave deicing technology - Wei Xia; Erlei Bai; Song Lu; Jinyu Xu; He Huang (Cold Regions Science and Technology, 2023)

Synergistically enhanced heat conductivity-microwave absorption capabilities of g-C3N4@Fe@C hollow micro-polyhedra via interface and composition modulation - Baoxin Fan; Lu Xing; Kaixia Yang; Fanjie Zhou; Qianmei He; Guoxiu Tong; Wenhua Wu (Chemical Engineering Journal, 2023)

Influence of thermal hydrolysis on sludge anaerobic digestion: Release of humic acid promotes electron transport of methanogen - Cheng Zhao; Hongbo Liu; He Liu; Xinmin Zhan; Xuedong Zhang; Bo Fu; Mingze Shi; Shuailing Lu; Fang Huang; Minhua Cui; Yajie Li (Chemical Engineering Journal, 2023)

Klebsiella oxytoca (EN-B2): A novel type of simultaneous nitrification and denitrification strain for excellent total nitrogen removal during multiple nitrogen pollution wastewater treatment - Tengxia He; Manman Zhang; Mengping Chen; Qifeng Wu; Li Yang; Lu Yang (Bioresource Technology, 2023)

Design and Applicability of an Abandoned Coal Mine Roadway for Landfill Sites - H. F. Lu; A. C. Wei; Z. A. He; F. Xu; X. X. Kong; Q. Z. Zhang (Water, Air, & Soil Pollution, 2023)

Combined population transcriptomic and genomic analysis reveals cis-regulatory differentiation of non-coding RNAs in maize - Jiawen Lu; Sihan Zhen; Jie Zhang; Yuxin Xie; Cheng He; Xiaoli Wang; Zheyuan Wang; Song Zhang; Yongxiang Li; Yu Cui; Guoying Wang; Jianhua Wang; et al. (Theoretical and Applied Genetics, 2023)

Preparation of Eu(III) Complexes Containing Maleopimaric Acid Anhydride with Ultra-narrow and Efficient Fluorescence Emission for High Determination on Gallic Acid in Acetonitrile Solution - Quliang Lu; He Liu; Dan Wang; Haibo Zhang; Shibin Shang (Journal of Fluorescence, 2023)

The Critical Factors and Preventive Measures of Impoundment of Tailings Using Active Surface Subsidence Zones - Yang Liu; Yanjun Zhou; Rongxing He; Jianli Cao; Fengyu Ren; Fu Yu; Lu Yue (Geotechnical and Geological Engineering, 2023)

Correction to: Exploring an online method of measuring implicit sequence-learning consciousness - Feng Lu; Chunlu Huang; Chuanlin Zhu; Yue He; Deming Shu; Dianzhi Liu (Experimental Brain Research, 2023)

Effects of the probability of pulse-like ground motions on landslide susceptibility assessment in near-fault areas - Jing Liu; Hai-ying Fu; Ying-bin Zhang; Pei-yi Xu; Run-dan Hao; Hai-hong Yu; Yun-yong He; Hong-yan Deng; Lu Zheng (Journal of Mountain Science, 2023)

Geochemical features of fluid in Xiaojiang fault zone, Southeastern Tibetan plateau: Implications for fault activity - Hongyi He; Zhi Chen; Zhaofei Liu; Zihan Gao; Le Hu; Chang Lu; Junjie Shao; Ying Li (Applied Geochemistry, 2023)

A new approach to peri-urban area land use efficiency identification using multi-source datasets: A case study in 36 Chinese metropolitan areas - Tingting He; Youpeng Lu; Wenze Yue; Wu Xiao; Xuehan Shen; Zhuoran Shan (Applied Geography, 2023)

Recovery of nutrients from aquaculture wastewater: Effects of light quality on the growth, biochemical composition, and nutrient removal of Chlorella sorokiniana - Yuqing He; Jie Lian; Lan Wang; Lu Tan; Fahad Khan; Yanhua Li; Hongxia Wang; Céline Rebours; Danxiang Han; Qiang Hu (Algal Research, 2023)

An improved cyclic multi model-eXtreme gradient boosting (CMM-XGBoost) forecasting algorithm on the GNSS vertical time series - Zhen Li; Tieding Lu; Xiaoxing He; Jean-Philippe Montillet; Rui Tao (Advances in Space Research, 2023)

Spatiotemporal changes of biogenic elements in the Changjiang River Estuary and adjacent waters in summer over the last decade - Lu Yang; Yujia Zhang; Xiaoli Wang; Qiulu Wang; Long He; Xiao Li (Acta Oceanologica Sinica, 2023)

Mixotrophic cultivation of microalgae for carotenoid production - Fakhra Liaqat; Mahammed Ilyas Khazi; Ali Bahadar; Lu He; Ayesha Aslam; Rabia Liaquat; Spiros N. Agathos; Jian Li (Reviews in Aquaculture, 2023)
The intrinsic ability of microalgae to accumulate high amounts of carotenoids has made them the preferred aquatic organisms of biotechnological exploration for carotenoid production. To continuously innovate and modify microalgal bioprocesses, aquaculture scientists have been working hard for the past decades in a forward‐looking way, and mixotrophic cultivation of microalgae is deemed as a promising strategy to decrease production cost. This review is intended to summarise the recent research advancement of carotenoids production from mixotrophically cultivated microalgae, starting from the structure, biosynthesis, physiological roles and applications of carotenoids and followed by the production processes both currently established and under development. Most importantly, the microalgal physiology of mixotrophic cultivation is reviewed in depth both in general and specifically for the most studied species, and the prospects of commercially viable mixotrophic microalgal processes for carotenoid production along with the insight of future research are of course discussed. Finally, we conclude that mixotrophy might be a promising strategy for large‐scale cultivation of microalgae to produce carotenoids although some technical obstacles need to be overcome.

Identification of light nonaqueous phase liquid groundwater contamination source based on empirical mode decomposition and deep learning - Jiuhui Li; Zhengfang Wu; Hongshi He; Wenxi Lu (Environmental Science and Pollution Research, 2022)

Evaluation and subgroup analysis of the efficacy and safety of intensive rosuvastatin therapy combined with dual antiplatelet therapy in patients with acute ischemic stroke - Ting Deng; Tong Zhang; Haitao Lu; Jingmian Chen; Xiaomeng Liu; Wei He; Xiaohua Yao (European Journal of Clinical Pharmacology, 2022)
Objectives We investigated the efficacy of intensive rosuvastatin therapy plus 7-day dual antiplatelet therapy (DAPT) in reducing stroke recurrence for patients with acute ischemic stroke (AIS) and compared subgroups of patients. Methods We enrolled patients with AIS whose time of onset to medication was ≤ 72 h, and the baseline scores of NIHSS (bNIHSS) were 0–10. The patients received intensive rosuvastatin therapy plus 7-day DAPT with aspirin and clopidogrel (study group) or rosuvastatin plus single antiplatelet therapy (SAPT, control group). The primary outcomes were recurrence of ischemic stroke, bleeding, statin-induced liver injury, and statin-associated myopathy (SAM) within 90 days. We also performed a subgroup analysis to assess the heterogeneity of the two therapy regimens in reducing recurrent stroke. Results Recurrent stroke occurred in 10 patients in the study group and 42 patients in the control group (hazard ratio [HR], 0.373, 95% confidence interval [CI], 0.178–0.780; P = 0.009). Bleeding events occurred in 9 patients in the study group and 14 patients in the control group (HR, 1.019; 95%CI, 0.441–2.353; P = 0.966). Statin-induced liver injury and SAM were not recorded. Intensive rosuvastatin plus 7-day DAPT was generally effective in reducing the risk of recurrent stroke, except in the subgroup with bNIHSS ≤ 2. The therapy was particularly efficient in the elderly, male, high-bNIHSS, and hypertension, diabetes, and hyperlipidemia subgroups, with P < 0.02. Conclusions Without increasing bleeding and statin-associated adverse events, intensive rosuvastatin therapy plus 7-day DAPT significantly reduced the risk of recurrent stroke, especially for subgroups with high-risk factors. Clinical trial registration . China Clinical Trial Registration Center (ChiCTR1800017809).

Macroporous honeycomb-like magnesium oxide fabricated as long-life and outstanding Pb(II) adsorbents combined with mechanism insight - Xingyu He; Jiarui Lu; Hong Wei; Baixiong Liu (Environmental Science and Pollution Research, 2022)

Synergistic effect of air pollutant abatement on CO2 reduction in the industrial sector: evidence from China - Nuo Liao; Lu Zhu; Yong He (Environmental Science and Pollution Research, 2022)

Study on low-temperature plasma γ-Al2O3 catalytic viscosity reduction of polyacrylamide solution - Xiaobing Wang; An Jin; Meng Zhu; Chen Feng; Hao He; Zhigang Huang; Kaifeng Li; Lu Wang (Environmental Science and Pollution Research, 2022)

Advances in the Technologies for Marine Salinity Measurement - Lijuan Gu; Xiangge He; Min Zhang; Hailong Lu (Journal of Marine Science and Engineering, 2022)
As one of the most important physical parameters of seawater, salinity is essential to study climatological change, to trace seawater masses and to model ocean dynamics. The traditional way to conduct salinity measurement in hydrographical observation is to use a standard conductivity-temperature-depth (CTD) probe where the salinity determination is based on a measurement of electrical conductivity. This article describes some developments of recent years that could lead to a new generation of instruments for the determination of salinity in seawater. Salinity determination with optical salinity sensor based on the refractive index measurement have been extensively studied. Different ways to conduct refractive index measurements are summarized, including measurements based on beam deviation, light wave mode coupling and swelling of surface coating material, among which the optical fiber sensors are promising candidates for further commercialization. Complementary to the above-mentioned direct measurement salinity point sensors, seismic observation takes advantages of large scale multichannel seismic data to retrieve the ocean salinity with high lateral resolution of ∼10 m. This work provide comprehensive information in the techniques related to the marine salinity measurement.

Sesquiterpenoids isolated from feces-residing Streptomyces sp. inhibit the cellular entry of influenza a viruses - Shengsheng Lu; Jianan Hu; Xi Xie; Ruifeng Huang; Jian He (Natural Product Research, 2022)

Construction of a m5C-related long non-coding RNA signature for the prognosis of hepatocellular carcinoma - Jing Lu; Haoyu Wang; Wanyue Cao; Desheng Chen; Zeping He; Junming Xu (Human Cell, 2022)

Correction to: Comparative analysis of groundwater contaminant sources identification based on simulation optimization and ensemble Kalman filter - Jiuhui Li; Zhengfang Wu; Hongshi He; Wenxi Lu (Environmental Science and Pollution Research, 2022)

Quantitative assessment of fibrosis-4 score and adverse clinical outcomes in patients with COVID-19 - Kefu Tang; Lu Wang; Lu Shen; Lin He; Xi Wu (Science China Life Sciences, 2022)

Effect and Mechanism of Cotrimoxazole Against Talaromyces marneffei in vitro - Jie Chen; Rongfeng Chen; Wudi Wei; Fengxiang Qin; Xiu Chen; Jinhao He; Hong Zhang; Gang Wang; Minjuan Shi; Tongxue Qin; Yinlu Liao; Yuting Wu; et al. (Mycopathologia, 2022)

Exploring an online method of measuring implicit sequence-learning consciousness - Feng Lu; Chunlu Huang; Chuanlin Zhu; Yue He; Deming Shu; Dianzhi Liu (Experimental Brain Research, 2022)

Comparative analysis of groundwater contaminant sources identification based on simulation optimization and ensemble Kalman filter - Jiuhui Li; Zhengfang Wu; Hongshi He; Wenxi Lu (Environmental Science and Pollution Research, 2022)

Rock thin sections identification under harsh conditions across regions based on online transfer method - Biao Wang; Guoqing Han; He Ma; Liying Zhu; Xingyuan Liang; Xin Lu (Computational Geosciences, 2022)

Taraxasterol Inhibits Hyperactivation of Macrophages to Alleviate the Sepsis-induced Inflammatory Response of ARDS Rats - Chanyuan Bu; Rui Wang; Yunyun Wang; Bing Lu; Songxiong He; Xiangyang Zhao (Cell Biochemistry and Biophysics, 2022)

Immunogenicity and protective efficacy of a DNA vaccine inducing optimal expression of the SARS-CoV-2 S gene in hACE2 mice - Zhuo-xin Li; Sheng Feng; He Zhang; Xin-yu Zhuang; Chao Shang; Shi-yu Sun; Ji-cheng Han; Yu-biao Xie; Jin-yong Zhang; Wei Wang; Cheng-hui Li; Guan-yu Zhao; et al. (Archives of Virology, 2022)

Pollution characteristics and risk assessment of heavy metals in surface water of Manas River, Xinjiang, China - Shaohua He; Bingbing Tian; Fengyu Liu; Junqi Wang; Shuyi Gong; Jianjiang Lu; Min Li (Arabian Journal of Geosciences, 2022)

Geochronology, geochemistry, and petrogenesis of I- and A-type granites in the Solwezi Dome of the Lufilian Arc: implications for the late-Mesoproterozoic magmatic and geodynamic evolution in northern Zambia - Kang-kang Xu; Wei Xie; Kai Sun; Jun-ping Ren; Peng-hui Gong; Sheng-fei He; Yi-guan Lu; Hang Zhang (Arabian Journal of Geosciences, 2022)

Correction to: Alpinia officinarum mediated copper oxide nanoparticles: synthesis and its antifungal activity against Colletotrichum gloeosporioides - Chunmei Hu; Wenjia Zhu; Ying Lu; Yanfang Ren; Jinyu Gu; Yaping Song; Junyu He (Environmental Science and Pollution Research, 2022)

Alpinia officinarum mediated copper oxide nanoparticles: synthesis and its antifungal activity against Colletotrichum gloeosporioides - Chunmei Hu; Wenjia Zhu; Ying Lu; Yanfang Ren; Jinyu Gu; Yaping Song; Junyu He (Environmental Science and Pollution Research, 2022)

Potential roles of MEK1 on aging in Argopecten scallops - Ke Yuan; Xia Lu; Junhao Ning; Min Chen; Quanchao Wang; Guilong Liu; Xin Xu; He Xu; Chunde Wang (Frontiers in Marine Science, 2022)
Dual specificity mitogen-activated protein kinase kinase 1 (MEK1) has been found to regulate aging through the Ras/Raf/MEK/ERK cascade in terrestrial animals. However, few reports have focused on MEK1 promoting aging in marine bivalves. In this study, we aimed to examine the potential roles of MEK1 in the regulation of aging in two Argopecten scallops, the bay scallop A. irradians and the Peruvian scallop A. purpuratus , which are closely related but with distinct lifespan. The complete ORFs of AiiMEK1 and ApuMEK1 were both 1209 bp, encoding 403 identical amino acids but with 41 synonymous SNPs, which may have contributed to the different activities of MEK1 in two scallops. Nutrient restriction, one of the most effective non-genetic means of promoting life span, significantly inhibit the expression of AiiMEK1 and ApuMEK1 . The response in hepatopancreas of A. irradians to nutrient restriction was more persistently than that in A. purpuratus . RNAi of AiiMEK1 significantly increased the expression of its downstream genes known to favor longevity, such as FoxO and SOD, while decreased the expression of ERK1/2 and the key genes in the mTOR signaling pathway, as well as the β-GAL activity (a marker for senescence). These results indicated that AiiMEK1 may play a negative role in longevity through Ras/Raf/MEK/ERK pathway. Our results may provide new perspective for understanding of the conservative functions of MEK1 in regulation of aging in animals and benefit the genetic selection of scallops.

Climate change increased the compound extreme precipitation-flood events in a representative watershed of the Yangtze River Delta, China - Yuxiu He; Qiang Wang; Youpeng Xu; Ziyi Li; Jia Yuan; Miao Lu; Zhixin Lin (Stochastic Environmental Research and Risk Assessment, 2022)

Numerical and Field Investigations of Rockburst Mechanisms Triggered by Thick-Hard Roof Fracturing - Zhi-Long He; Cai-Ping Lu; Xiu-Feng Zhang; Ying Guo; Zhao-He Meng; Lei Xia (Rock Mechanics and Rock Engineering, 2022)

Germanium enrichment in sphalerite with acicular and euhedral textures: an example from the Zhulingou carbonate-hosted Zn(-Ge) deposit, South China - Kai Luo; Alexandre Cugerone; Mei-Fu Zhou; Jia-Xi Zhou; Guo-Tao Sun; Jing Xu; Kang-Jian He; Mao-Da Lu (Mineralium Deposita, 2022)

Optimized structural parameters and heat extraction capacity of a mixing device for constant pressure CO2 mineralization using alkaline waste - Wei Lu; Yang Yuan; Xiangming Hu; Guansheng Qi; Lulu Sun; Maoyuan Zhang; MingJun Wang; Min He (Environmental Science and Pollution Research, 2022)

Associations of exposure to lead and cadmium with risk of all-cause and cardiovascular disease mortality among patients with type 2 diabetes - Kai Zhu; Yuge Zhang; Qi Lu; Tingting Geng; Rui Li; Zhenzhen Wan; Xuena Zhang; Yujie Liu; Lin Li; Zixin Qiu; Meian He; Liegang Liu; et al. (Environmental Science and Pollution Research, 2022)

Characterization of a Hyaluronidase-Producing Bacillus sp. CQMU-D Isolated from Soil - Lu Wang; Qianqian Liu; Rui Hao; Jing Xiong; Junxing Li; Yanan Guo; Lu He; Zeng Tu (Current Microbiology, 2022)

Complete genome sequence of iris potyvirus B infecting Lilium lancifolium in China - Qi Lin; Dankan Yan; Mengying Hua; Yueyan Yin; Hongying Zheng; Jianping Chen; Fei Yan; Jiejun Peng; Qiongji He; Yuwen Lu (Archives of Virology, 2022)

Long‐term drought aggravates instability of alpine grassland productivity to extreme climatic event - Yun L. He; Jin S. Wang; Da S. Tian; Quan Quan; Lin Jiang; Fang F. Ma; Lu Yang; Fang Y. Zhang; Qing P. Zhou; Shu L. Niu (Ecology, 2022)
The frequency and severity of extreme weather events are increasing and expected to increase more in the future, together with global change. However, how extreme events and global change factors interactively influence community structures and ecosystem processes is largely unknown. Here, we investigated the responses of the temporal stability and resilience of aboveground net primary productivity (ANPP) of an alpine meadow to an extreme flooding event under different treatments of experimental drought and clipping. We found that ecosystems that were exposed to drought treatments for 3 years significantly decreased the temporal stability of community productivity but increased resilience to flooding, whereas their resistance to or recovery from flooding did not change. Neither clipping nor its interaction with drought altered the responses of these community stability metrics to flooding. Drought treatments significantly decreased plant species richness and asynchrony and dominant species stability, leading to a decrease in temporal stability and an increase in resilience in response to the extreme flooding event. The study also revealed that the change in species asynchrony was the dominant impact pathway determining the responses of resilience and temporal stability to flooding. Our results highlight that alpine grassland that experiences a multiyear drought may aggravate the instability of community productivity to extreme climatic events by reducing species asynchrony.

Two new triterpenoid glycosides from leaves of Cyclocarya paliurus - Huihui Sun; Hui Zhu; Jianping Wu; Yuyan Wang; Guihua Li; Yiqian Liu; Xiwen Chang; Saiyu Ou; Wenwen Zha; Huiyun Chen; Rui Gui; Xiaoai He; et al. (Natural Product Research, 2022)

Devonian upper ocean redox trends across Laurussia: Testing potential influences of marine carbonate lithology on bulk rock I/Ca signals - Ruliang He; Maya Elrick; James Day; Wanyi Lu; Zunli Lu (Frontiers in Marine Science, 2022)
The Devonian is characterized by major changes in ocean-atmosphere O 2 concentrations, colonialization of continents by plants and animals, and widespread marine anoxic events associated with rapid δ 13 C excursions and biotic crises. However, the long-term upper ocean redox trend for the Devonian is still not well understood. This study presents new I/Ca data from well-dated Lower Devonian through Upper Devonian limestone sections from the Great Basin (western Laurussia) and the Illinois Basin (central Laurussia). In addition, to better address potential influences of lithology and stratigraphy on I/Ca redox signals, I/Ca data are reported here as carbonate lithology-specific. Results indicate that lithologic changes do not exert a dominant control on bulk carbonate I/Ca trends, but the effects of some diagenetic overprints cannot be ruled out. For the Illinois Basin, low I/Ca values (more reducing) are recorded during the Pragian to Emsian and increased but fluctuating values are recorded during the Eifelian to Givetian. The Great Basin I/Ca trends suggest local upper oceans were more reducing in the Lochkovian, more oxic in the Pragian-Emsian, return to more reducing in the Eifelian, then to increasingly more oxic, but fluctuating in the Givetian-Frasnian. The local I/Ca variations at Great Basin likely share more similarity with global upper ocean condition (compared to the Illinois Basin) based on its position adjacent to the Panthalassic Ocean and its temporal co-variation with global environmental volatility trends. The overall reducing and variable redox conditions of local upper ocean (if not a diagenetic signal) during the Middle and Late Devonian of Great Basin coincide with evidence of increased global environmental volatility suggesting seawater redox may have been an important part of environmental instability at this time.

Association of exposure to multiple serum metals with the risk of chronic kidney disease in the elderly: a population-based case–control study - Wenlei Hu; Guoao Li; Jialiu He; Huanhuan Zhao; Hanshuang Zhang; Huanhuan Lu; Jianjun Liu; Fen Huang (Environmental Science and Pollution Research, 2022)

Nitrogen uptake by plants may alleviate N deposition-induced increase in soil N2O emissions in subtropical Chinese fir (Cunninghamia lanceolata) plantations - Xiang Zheng; Qi Liu; Minmin Cao; Xiaofang Ji; Jianbing Lu; Liu He; Lingjuan Liu; Shenglong Liu; Jiang Jiang (Plant and Soil, 2022)

Microseismic Monitoring of Hydraulic Fracture Propagation and Seismic Risks in Shale Reservoir with a Steep Dip Angle - Zhaohui Lu; Yunzhong Jia; Lijun Cheng; Zhejun Pan; Liangjun Xu; Pei He; Xiaozhong Guo; Liming Ouyang (Natural Resources Research, 2022)

The Key Role of Magnetic Resonance Imaging in the Detection of Neurodegenerative Diseases-Associated Biomarkers: A Review - Ke-Ru Li; An-Guo Wu; Yong Tang; Xiao-Peng He; Chong-Lin Yu; Jian-Ming Wu; Guang-Qiang Hu; Lu Yu (Molecular Neurobiology, 2022)

Is higher ambient temperature associated with acute appendicitis hospitalizations? A case-crossover study in Tongling, China - Yuxuan Li; Xuelian Luo; Yudong Wu; Shuangshuang Yan; Yunfeng Liang; Xiaoyu Jin; Xiaoni Sun; Lu Mei; Chao Tang; Xiangguo Liu; Yangyang He; Weizhuo Yi; et al. (International Journal of Biometeorology, 2022)

Outdoor air pollution enhanced the association between indoor air pollution exposure and hypertension in rural areas of eastern China - Guoao Li; Huanhuan Lu; Wenlei Hu; Jianjun Liu; Mingjun Hu; Jialiu He; Fen Huang (Environmental Science and Pollution Research, 2022)

Ultrasensitive electrochemical detection of bisphenol A using composites of MoS2 nanoflowers, CoS2 nano-polyhedrons and reduced graphene oxide - Jingjing Yuan; Bingji Huang; Yuchen Lu; Ling Jiang; Guangyu He; Haiqun Chen (Environmental Chemistry Letters, 2022)

Exosomal targeting and its potential clinical application - Jiao He; Weihong Ren; Wei Wang; Wenyan Han; Lu Jiang; Dai Zhang; Mengqi Guo (Drug Delivery and Translational Research, 2022)
Exosomes are extracellular vesicles secreted by a variety of living cells, which have a certain degree of natural targeting as nano-carriers. Almost all exosomes released by cells will eventually enter the blood circulation or be absorbed by other cells. Under the action of content sorting mechanism, some specific surface molecules can be expressed on the surface of exosomes, such as tetraspanins protein and integrin. To some extent, these specific surface molecules can fuse with specific cells, so that exosomes show specific cell natural targeting. In recent years, exosomes have become a drug delivery system with low immunogenicity, high biocompatibility and high efficacy. Nucleic acids, polypeptides, lipids, or small molecule drugs with therapeutic function are organically loaded into exosomes, and then transported to specific types of cells or tissues in vivo, especially tumor tissues, to achieve targeting drug delivery. The natural targeting of exosome has been found and recognized in some studies, but there are still many challenges in effective clinical treatments. The use of the natural targeting of exosomes alone is incapable of accurately transporting the goods loaded to specific sites. Besides, the natural targeting of exosomes is still an open question in disease targeting and efficient gene/chemotherapy combined therapy. Engineering transformation and modification on exosomes can optimize its natural targeting and deliver the goods to a specific location, providing wide use in clinical treatment. This review summarizes the research progress of exosomal natural targeting and transformation strategy of obtained targeting after transformation. The mechanism of natural targeting and obtained targeting after transformation are also reviewed. The potential value of exosomal targeting in clinical application is also discussed. Graphical abstract

Histone methyltransferase GLP epigenetically activates GPCPD1 to sustain cancer cell metastasis and invasion - He Wen; Minghui Shu; Jia-Yi Chen; Xiaofan Li; Qian Zhu; Jun Zhang; Yuan Tian; Xiaopeng Lu; Wei-Guo Zhu (Genome Instability & Disease, 2022)
Disordered choline metabolism is associated with tumor progression. Glycerophosphocholine phosphodiesterase 1 (GPCPD1) is critical for cleaving glycerophosphocholine (GPC) to produce choline. However, whether and how GPCPD1 is epigenetically regulated remains largely unknown. In the current study, we report that histone H3 lysine 9 (H3K9) methyltransferase GLP (G9a-like Protein) is essential for transcriptional activation of GPCPD1 through H3K9me1 to promote tumor cell migration and invasion. Knocking down GLP or inhibiting its methyltransferase activity impaired GPCPD1 expression and decreased the choline levels. Importantly, we confirmed that both GPCPD1 and choline levels are positively correlated with cancer cell migration. The reduced migration and invasion of GPCPD1-knockdown cells were rescued by choline treatment. Interestingly, GPCPD1 gene expression was found regulated by transcription factor Krüppel-like Factor 5 (KLF5). KLF5 recruitment was GLP-dependent and was indispensable for GPC-induced GPCPD1 expression. These data suggest that GLP promotes tumor cell migration and invasion by transcriptionally activating GPCPD1 . GLP and KLF5 are potential therapeutic targets in future cancer treatment.

Rapid visual detection of Enterocytozoon hepatopenaei by recombinase polymerase amplification combined with lateral flow dipstick - Jianhu Pang; Caiyuan Zhao; Hualong Su; Zhongcheng Liu; Qiang Lu; Xinyi He; Shaoping Weng; Jianguo He (Frontiers in Marine Science, 2022)
Enterocytozoon hepatopenaei (EHP) is a high-impact pathogen in shrimp farming, causing huge economic losses to the global shrimp farming industry every year. However, current EHP detection methods are primarily based on the development of polymerase chain reaction (PCR) techniques that rely on sophisticated and expensive instruments. Consequently, a rapid, practical, and sensitive protocol for the detection of EHP is necessary. Recombinase polymerase amplification combined with a lateral flow dipstick (LFD-RPA) assay was developed using a pair of primers and nfo-probe targeting the conserved region of the spore wall protein gene. Under optimized reaction conditions, the LFD-RPA assay can detect 10 copies/μL of standard plasmid within 20 min at 40°C. Furthermore, the specificity of the LFD-RPA was also verified with other common pathogens of shrimp. Thirty-nine samples of Litopenaeus vannamei were collected in shrimp farms and detected using LFD-RPA and nested PCR. Thirty-two positive samples were detected by LFD-RPA. Compared with those of nested PCR, the diagnostic sensitivity and specificity of LFD-RPA were 100% and 100%, respectively. These results indicated the great application potential of the newly developed LFD-RPA assay for point-of-care diagnosis, epidemic surveillance, and epidemiological investigation of EHP.

Editorial: Carbon storage by marine microorganisms for carbon neutrality - Zhili He; Lu Lin; Xin Wang; Wei Qin; Chuanlun Zhang (Frontiers in Marine Science, 2022)

Wheat genomic study for genetic improvement of traits in China - Jun Xiao; Bao Liu; Yingyin Yao; Zifeng Guo; Haiyan Jia; Lingrang Kong; Aimin Zhang; Wujun Ma; Zhongfu Ni; Shengbao Xu; Fei Lu; Yuannian Jiao; et al. (Science China Life Sciences, 2022)

Ectopic Expression of Erigeron breviscapus JAZ1 Affects JA-Induced Development Processes in Transgenic Arabidopsis - Mo Chen; Wei Zhang; Mi Yan; Simei He; Yingchun Lu; Guanghui Zhang; Bing Hao; Wei Fan; Yanru Hu; Shengchao Yang (Plant Molecular Biology Reporter, 2022)

Effect of different decay classes of Eucalyptus stump substrates on microbial resource limitation and carbon-use efficiency - Xiangsheng Deng; Fei Cheng; Mingman Li; Peng He; Lu Shen; Haiyu Liu (Plant and Soil, 2022)

Identification of the glutamine synthetase (GS) gene family in four wheat species and functional analysis of Ta4D.GSe in Arabidopsis thaliana - Huayan Yin; Qian Sun; Xiaoqing Lu; Lufei Zhang; Yanchao Yuan; Cuiling Gong; Xiaoyan He; Wujun Ma; Ping Mu (Plant Molecular Biology, 2022)
Drought stress can negatively impact crop yield and quality. Improving wheat yields under drought stress is a major objective of agronomic research. Glutamine synthetase (GS) is a key enzyme of nitrogen metabolism that is critical to plant growth and development in abiotic stress response. However, to date, no systemic characterization of the GS genes has yet been conducted in wheat and its close relatives. We identified a total of 15 GS genes in Triticum aestivum (2n = 6x = 42; AABBDD), as well as 9 GS genes in Triticum dicoccoides (2n = 4x = 28; AABB), 6 in Aegilops tauschii (2n = 2x = 14; DD), and 5 in Triticum urartu (2n = 2x = 14; AA). The 35 GSs were further clustered into five lineages according to the phylogenetic tree. Synteny analysis revealed that the three subgenomes in bread wheat retained extensive synteny between bread wheat and its three relative species. We identified three up-regulated TaGSs ( Ta4A.GSe , Ta4B.GSe , and Ta4D.GSe ) from transcriptome data after drought and salt stress. Ta4D.GSe was subsequently used for further functional studies, and its subcellular localization were determined in Arabidopsis protoplasts. Its overexpression in Arabidopsis enhanced drought tolerance by increasing the ability of scavenging of reactive oxygen species (ROS) and osmotic adjustment. We identified GS gene family in four wheat species and performed comparative analyses of their relationships, chromosome locations, conserved motif, gene structure, and synteny. The subcellular localization of Ta4D.GSe was detected and its drought tolerance function was demonstrated. Taken together, these findings provide insight into the potential functional roles of the GS genes in abiotic stress tolerance. Key message This report clearly shows detailed characterization of GS gene family in four wheat species and demonstrates that Ta4D.GSe plays an important role in enhancing drought tolerance by improving the scavenging of ROS and osmotic adjustment ability in Arabidopsis .

Novel Self-Assembled Micelles With Increased Tumor Penetration and Anti-Tumor Efficiency Against Breast Cancer - Yani Yang; Yuezhu Zhao; Jie Liu; Chen Ge; Weiwei Zhang; Yue Zhang; Junji Wang; Guohao Sun; Xiujun Lin; Xiaohong Lu; Xiang Tang; Jun He; et al. (Pharmaceutical Research, 2022)

Cordycepin enhances hyperthermia-induced apoptosis and cell cycle arrest by modulating the MAPK pathway in human lymphoma U937 cells - Liying Shi; He Cao; Siyu Fu; Zixian Jia; Xuan Lu; Zhengguo Cui; Dayong Yu (Molecular Biology Reports, 2022)

Physiological and molecular responses of invasive cyanobacterium Raphidiopsis raciborskii to ambient phosphorus deficiency - Junqiong Shi; Shuhan He; Lu Zhao; Lulu Ji; Songqi Yang; Zhongxing Wu (Journal of Oceanology and Limnology, 2022)

An automatic ordering method for streams in surface-water/groundwater interaction modeling - Chengcheng Xu; Chu Wu; Tianchen Li; Chuiyu Lu; Xin He; Qingyan Sun; Tao Qin; Lingjia Yan (Hydrogeology Journal, 2022)

Deformation Characteristics and Mechanism of Side Walls of Wudongde Hydropower Station - Lu Weiyong; He Changchun (Geotechnical and Geological Engineering, 2022)

Environmentally relevant concentrations of triclosan exposure promote the horizontal transfer of antibiotic resistance genes mediated by Edwardsiella piscicida - Jinfang Lu; He Zhang; Liangliang Pan; Wanchun Guan; Yongliang Lou (Environmental Science and Pollution Research, 2022)

Hyphomonas sediminis sp. nov., isolated from marine sediment - Lu Wang; Wei He; Zeng-Yu Gao; Dao-Feng Zhang; Jian-Ke Huang; Chuang Liu; Wen-Jun Li; Ai Hua Zhang (Antonie van Leeuwenhoek, 2022)

Age, Growth and Population Structure Analyses of the Purpleback Flying Squid Sthenoteuthis oualaniensis in the Northwest Indian Ocean by Beak Microstructure - Hua-Jie Lu; Yu-Zhe Ou; Jing-Ru He; Mao-Lin Zhao; Zi-Yue Chen; Xin-Jun Chen (Journal of Marine Science and Engineering, 2022)
To explore the feasibility of using beak microstructure information to estimate the age of Sthenoteuthis oualaniensis, the microstructures of the upper beaks of individual squid were applied in this work to analyze the ages and growth patterns of squid caught from February–May 2019 and from October–December 2020 in the northwest Indian Ocean. The results indicated that the squid samples in the two years were no older than 9 months, and the samples in 2019 were autumn population and 2020 were spring population. The linear growth model of the autumn population (2019) was the best model for describing the relationship between age and ML, while the power model of the spring population (2020) was the best for describing the relationship between age and ML. The maximum instantaneous growth rate (IGR) and absolute daily growth rate (AGR) values of the spring population were 0.24%/d and 1.09 mm/d, respectively, occurring in squid between 200 and 220 days of age. The maximum IGR and AGR values of the autumn population were 0.69%/d and 1.73 mm/d, respectively, occurring in squid between 200 and 240 days of age. The period from 141–260 days (5–8 months) was considered to correspond to the subadult stage in the whole life history of S. oualaniensis in the Northwest Indian Ocean. The beak microstructure information can be effectively applied to estimate the age of S. oualaniensis individuals.

MiR-223-3p-loaded exosomes from bronchoalveolar lavage fluid promote alveolar macrophage autophagy and reduce acute lung injury by inhibiting the expression of STK39 - Nan He; Haoyu Tan; Xueyu Deng; Lu Shu; Bei Qing; Hengxing Liang (Human Cell, 2022)

Characteristics and source analysis of greenhouse gas concentration changes at Akedala Station in Central Asia - Zhujun Zhao; Zhongqi Lu; Qing He; Quanwei Zhao; Jianlin Wang (Theoretical and Applied Climatology, 2022)

Variations in different types and levels of daily precipitation in the Tarim Basin, Northwest China - Alim Abbas; Taixi Zhang; Qing He; Lu Bo; Lili Jin; Junlan Zhang; Akida Salam (Theoretical and Applied Climatology, 2022)

VGLUT3 neurons in median raphe control the efficacy of spatial memory retrieval via ETV4 regulation of VGLUT3 transcription - Aodi He; Chen Zhang; Xiao Ke; Yao Yi; Quntao Yu; Tongmei Zhang; Hongyan Yu; Huiyun Du; Hao Li; Qing Tian; Ling-Qiang Zhu; Youming Lu (Science China Life Sciences, 2022)

Chitosan and D-fructose 1,6-bisphosphate differ in their effects on soil acidity and aluminum activation - Jackson Nkoh Nkoh; Xian He; Hai-long Lu; Ke-wei Li; Ren-yong Shi; Jiu-yu Li; Ren-kou Xu (Journal of Soils and Sediments, 2022)

Microplastic pollution in urban green-belt soil in Shihezi City, China - Xiaodong Liu; Shaohua He; Yanbin Tong; Zilong Liu; Weijun Li; Nuerguli Xiayihazi; Jianjiang Lu (Environmental Science and Pollution Research, 2022)

Construction of a mutant Bacillus subtilis strain for high purity poly-γ-glutamic acid production - Linlin He; Lu Liu; Rui Ban (Biotechnology Letters, 2022)

Global regulatory factor VeA upregulates the production of antitumor substances in endophytic Fusarium solani - Lu Cai; Jiankang Wang; Yongjie Li; Min Qin; Xuemin Yin; Zhangjiang He; Jichuan Kang (Antonie van Leeuwenhoek, 2022)

Promoted reductive removal of chlorinated organic pollutants co-occurring with facilitated methanogenesis in anaerobic environment: A systematic review and meta-analysis - Jie Cheng; Jing Yuan; Shuyao Li; Xueling Yang; Zhijiang Lu; Jianming Xu; Yan He (Critical Reviews in Environmental Science and Technology, 2022)

Cis-element amplified polymorphism (CEAP), a novel promoter- and gene-targeted molecular marker of plants - Meiyan Chen; Xinhua He; Xing Huang; Tingting Lu; Yili Zhang; Jiawei Zhu; Haixia Yu; Cong Luo (Physiology and Molecular Biology of Plants, 2022)

Molecular mechanism of microRNAs regulating apoptosis in osteosarcoma - Xueyang Cai; Wei Yin; Chao Tang; Yubao Lu; Yuqi He (Molecular Biology Reports, 2022)

Pharmacokinetics of benapenem for injection in subjects with mild to moderate renal impairment - Haijing Yang; Min Zhang; Yuancheng Chen; Hong Ren; Hong Zhang; Chen Yu; Jianda Lu; Li You; Jicheng Yu; Hong Liang; Cuilan Xiao; Zishuang He; et al. (European Journal of Clinical Pharmacology, 2022)

Identification of candidate genes for easily-shelled traits in Tartary buckwheat based on BSA-Seq and RNA-Seq methods - Ying Duan; Guifang Yin; Runli He; Xiaolin Yang; Suyun Cai; Yanqing Wang; Wenjie Lu; Daowang Sun; Lihua Wang; Yongqin Wang; Honghe Sun (Euphytica, 2022)

Assessing economic sustainability and ecological efficiency with genuine progress indicator: a case study of the Yangtze River Delta from 2000 to 2018 - Yongjun Li; Jing Qiao; Lei Xie; Lingyan Huang; Yue Su; Mengmeng Zhou; Ke Wang; Jing Zhang; Shan He; Lu Huang (Environmental Science and Pollution Research, 2022)

Biosynthesis of valerenic acid by engineered Saccharomyces cerevisiae - Mengya Zhao; Chuanbo Zhang; Haibin Wang; Shifan He; Wenyu Lu (Biotechnology Letters, 2022)

The Welfare of Nile Tilapia (Oreochromis niloticus, GIFT Strain) Juveniles Cultured in Different Light Spectra - Mengmeng Yi; Wanting Zhai; Miao Wang; He Wang; Zhigang Liu; Fengying Gao; Xiaoli Ke; Changbin Song; Jianmeng Cao; Maixin Lu (Frontiers in Marine Science, 2022)
The light spectrum is a vital environmental factor for the culture of fish, and the welfare of farmed fish is a crucial issue in aquaculture. In this study, Nile tilapia ( Oreochromis niloticus , GIFT strain) juveniles were exposed to full-spectrum (LW), red (LR), yellow (LY), or blue (LB) light. After the 45-day experiment, growth performance, stress responses, and aggressive behaviors were evaluated, and transcriptomic analysis was carried out. The results revealed that LW and LR positively affected growth performance. At the same time, LY and LB had a negative effect. Light spectrum induced stress responses of juvenile fish exposed to LY, under which the total antioxidant capacity (T-AOC) and cortisol (COR) contents were the highest. The activities of α-amylase (AMS), protease (PES), and lipase (LPS) in the digestive tract showed a similar tendency, indicating that the light spectra altered the digestive enzyme activities and then affected growth. Behavioral analyses showed increased chase and bite activities of tilapia juveniles exposed to LW and LY. The affected functions included the nervous system, muscle morphogenesis, and immune system-related regulation. Enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways include the tryptophan metabolism signaling pathway, protein digestion and absorption signaling pathway, Jak-STAT signaling pathway, arachidonic acid metabolism signaling pathway, and alpha-linolenic acid metabolism signaling pathway. Overall, light spectra influenced the welfare of farmed tilapia juveniles in terms of growth, stress, and behavior. Our results suggested that LR should be used in juvenile tilapia culture.

Large-scale evaluation of aluminum tolerance in maize (Zea mays L.) acessions - Jianzhou Ding; Wei Yang; Xiaoqi Hu; Weina Yan; Wanpeng Hu; Hongjie Li; Chan Liu; Wenzhu He; Yanli Lu; Shibin Gao; Suzhi Zhang (Theoretical and Experimental Plant Physiology, 2022)

Prediction of drought/flood intensities based on a 500-year time series in three different climate provinces of China - Yu Peng; Zhaohua Wang; Yixin Cui; Yali Su; Yiyun Tang; Shiqian Luo; Lianlin Liu; Yanqiu Zhou; Jihui Dong; Wentao Wang; Xiang Li; Jiaxin Shang; et al. (Regional Environmental Change, 2022)

MSFF-Net: Multi-Scale Feature Fusion Network for Gastrointestinal Vessel Segmentation - Sheng Li; Cheng Lu; Xueting Kong; Jinhui Zhu; Xiongxiong He; Ni Zhang (Journal of Medical and Biological Engineering, 2022)

The effects of berberine on inflammatory markers in Chinese patients with metabolic syndrome and related disorders: a meta‑analysis of randomized controlled trials - Yuqiong Lu; Xiwen Zhang; Jiafang He; Zhanjing Dai; Penghua Shi; Yun Lu; Feng Chang (Inflammopharmacology, 2022)
Background A meta-analysis of randomized controlled trials (RCTs) was conducted to systematically evaluate the effects of berberine on the inflammatory markers of metabolic syndrome (MetS) and related disorders. Method Databases that were searched from inception to October 2020 included PubMed, Web of Science, the Cochrane Library, CNKI, VIP, WanFang Data, and ClinicalTrials.gov. Two reviewers independently selected articles and extracted data. The pooled evaluations were entered and analyzed in Review Manager 5.3. Results Of the 7387 publications screened, 52 studies were included, and the related trials involved 4616 patients. Pooled estimates showed that the use of berberine could significantly reduce the concentration level of C-reactive protein (CRP) [standardized mean difference (SMD) = − 1.54, 95% confidence intervals (CI) − 1.86, − 1.22, p < 0.05], tumor necrosis factor-α (TNF-α) [SMD = − 1.02, 95% CI − 1.27, − 0.77, p < 0.05], and interleukin 6 (IL-6) [SMD = − 1.17, 95% CI − 1.53, − 0.81, p < 0.05] among patients with MetS and related disorders. However, it did not affect the level of interleukin 1β (IL-1β) [SMD = − 0.81, 95% CI − 1.80, 0.17, p = 0.11]. Conclusion Overall, the use of berberine in patients with MetS and related disorders appeared to significantly decrease several inflammatory markers. Further multi-center and rigorous investigations with larger patient populations are encouraged to confirm the effect of berberine on MetS and related disorders.

Integration of manganese accumulation, subcellular distribution, chemical forms, and physiological responses to understand manganese tolerance in Macleaya cordata - Langjun He; Rongkui Su; Yonghua Chen; Peng Zeng; Lu Du; Bin Cai; Aoshan Zhang; Honghong Zhu (Environmental Science and Pollution Research, 2022)

Evaluation of China’s forest carbon sink service value - Xiaoliang Shi; Tielong Wang; Shuaiyu Lu; Ke Chen; Dan He; Zhe Xu (Environmental Science and Pollution Research, 2022)

Experimental investigations and microscopic analyses of chemical effects and dry density on the swelling behavior of compacted bentonite - Pu-huai Lu; Yong He; Wei-min Ye; Yong-gui Chen; Ke-neng Zhang (Bulletin of Engineering Geology and the Environment, 2022)

The formation of biogenic reef stone: from coral skeleton to reef rubble - Yixin Li; Fengjuan Wang; Zhiyong Liu; Jinyang Jiang; Tingyu Han; Xin Liao; Chunpeng He; Zuhong Lu (Journal of Oceanography, 2022)

Logging calculation method and application of geochemical parameters of source rocks with different lithologies in marine-continental transitional facies in Ordos Basin, China - Li Ping Zhao; Jungang Lu; Xiaogang Li; Yong Li; Qingbo He; Zhiwei Ma (Arabian Journal of Geosciences, 2022)

Microcosmic Characteristics of Hydrate Formation and Decomposition in the Different Particle Size Sediments Captured by Cryo-SEM - Jingsheng Lu; Decai Lin; Dongliang Li; Deqing Liang; Long Wen; Siting Wu; Yiqun Zhang; Yong He; Lingli Shi; Youming Xiong (Journal of Marine Science and Engineering, 2022)
Sand production and sand control studies in non-diagenetic reservoirs are the weak point in the conventional petroleum industry. However, natural gas hydrate (NGH) mainly exists in non-diagenetic strata, and sand production occurs during exploitation, which restricts the safe and sustainable production of NGH. To study the microcosmic characteristics of sand production, the hydrate decomposition behaviours in the sediments were captured by the Cryo-SEM method. The micromorphology of different particle sizes of sand samples containing NGH (the sand median diameter d50 is 150, 87, 55, 38, 24, and 13 µm) and the microcosmic processes of NGH decomposition were observed. Then, the microcosmic characteristics of sand production, during the decomposition process, were analysed. (1) The gas hydrate decomposition increases pore space and reduces reservoir strength; the expansion action of the decomposition of water and gas, the softening action of the decomposition of water, and the compression action by overlying stress (crustal stress) promoted sand production, deformation, and subsidence of the NGH reservoirs in the mining process. (2) The decomposition of NGH has a more significant impact on sediments with smaller particle sizes. (3) The particle size of NGH may be larger than the particle size of the mud in the reservoirs, and acting as “gravel” plays a particular role in sand control. Therefore, the particle size of NGH cannot be ignored in the design of sand control. (4) It has been revealed, and verified, that sputtering (splashing) is a unique process of sand production caused by NGH decomposition. In other words, the rapid expansion of the volume of the decomposed gas and water from NGH leads to the eruption and sputtering of hydrate particles, providing the driving force for sand migration, which is a different process of sand production than in conventional oil and gas.

A SOM−RBFnn-Based Calibration Algorithm of Modeled Significant Wave Height for Nearshore Areas - Hengyu Hu; Zhengwei He; Yanfang Ling; Junmin Li; Lu Sun; Bo Li; Junliang Liu; Wuyang Chen (Journal of Marine Science and Engineering, 2022)
In this paper, a calibration algorithm for forecasting the significant wave height (SWH) in nearshore areas is proposed, based on artificial neural networks. The algorithm has two features: first, it is based on SOM−BRFnn (self−organizing map–radial basis function neural network) to better reflect the clustering characteristics of the input parameters regarding wind and wave. In addition, the high-frequency variation part and the low-frequency variation part of SWH are separated by a threshold of 24 h to better describe the diurnal variation of SWH under the influence of tidal current. The algorithm is applied to the nearshore region of Nan-ao Island in the northeastern South China Sea. The results show that the algorithm can effectively correct the modeling results of nearshore SWH. Compared with the original outputs of the ERA5 model, the correlation coefficient is increased from 0.472 to 0.774, the root mean square error is reduced from 0.252 m to 0.103 m, and the mean relative error is reduced from 41% to 17.6%, respectively. Further analysis indicates that the frequency division is crucial in realizing the correction of the high-frequency variation of SWH. The results have reference significance for the application of wave numerical models in coastal areas.

G9a/GLP catalyzes H3K14me1 and H3K14me2 in vivo and in vitro - Qian Zhu; Jiayi Chen; Xiaopeng Lu; He Wen; Wei-Guo Zhu (Science China Life Sciences, 2022)

A Coupled THM Model for Simulating Mechanical Response of Open Pit and Underground Stope to the Filling of the Pit - Yong Yang; Di Wu; Lu He (Geotechnical and Geological Engineering, 2022)

Microbial communities in swamps of four mangrove reserves driven by interactions between physicochemical properties and microbe in the North Beibu Gulf, China - Lu Li; Chunyan Peng; Zicong Yang; Yu He; Meng Liang; Hongmin Cao; Qinghua Qiu; Jingjing Song; Youlu Su; Bin Gong (Environmental Science and Pollution Research, 2022)

Increased annual methane uptake driven by warmer winters in an alpine meadow - Peiyan Wang; Jinsong Wang; Bo Elberling; Lu Yang; Weinan Chen; Lei Song; Yingjie Yan; Song Wang; Junxiao Pan; Yunlong He; Shuli Niu (Global Change Biology, 2022)
Pronounced nongrowing season warming and changes in soil freeze–thaw (F–T) cycles can dramatically alter net methane (CH 4 ) exchange rates between soils and the atmosphere. However, the magnitudes and drivers of warming impacts on CH 4 uptake in different stages of the F–T cycle are poorly understood in cold alpine ecosystems, which have been found to be a net sink of atmospheric CH 4 . Here, we reported a year‐round ecosystem daily CH 4 uptake in an alpine meadow on the Qinghai‐Tibetan Plateau after a 5‐year warming experiment that included a control, a low‐level warming treatment (+2.4℃ at 5 cm soil depth), and a high‐level warming treatment (+4.5℃ at 5 cm soil depth). We found that warming shortened the F–T cycle under the low‐level warming and soils did not freeze under the high‐level warming. Although both warming treatments increased the mean CH 4 uptake rate, only the high‐level warming significantly increased annual CH 4 uptake compared to the control. The warming‐induced stimulation of CH 4 uptake mainly occurred in the cold season, which was mostly during spring thaw under low‐level warming and during the frozen winter under high‐level warming due to a longer period with thawed soil. We also found that warming significantly stimulated daily CH 4 uptake mainly by reducing near‐surface soil water content in the warm season, whereas both soil water content and temperature controlled daily CH 4 uptake in different ways during the autumn freeze, frozen winter, and spring thaw periods of the control. Our study revealed a strong warming effect on CH 4 uptake during the entire F–T cycle in the alpine meadow, especially the unfrozen winter. Our results also suggested the important roles of soil pH, available phosphorus, and methanotroph abundance in regulating annual CH 4 uptake in response to warming, which should be incorporated into biogeochemical models for accurately forecasting CH 4 fluxes under future climate scenarios.

Simultaneous determination of praziquantel and its main metabolites in the tissues of black goats and their residue depletion - Tong-Yan Ding; Xiao-Gui Shu; Ren-Ping Xiong; Jing-Li Qiu; Lu Li; Li-Min He (Food Additives & Contaminants: Part A, 2022)

Effects of inorganic alkalis and organic anions in biochars on acidic paddy soil resistance to acidification - Xian He; Hai-long Lu; Cong-min Wu; Ren-kou Xu (Journal of Soils and Sediments, 2022)

Rapid calibration of HY-2A satellite-borne microwave radiometer using coastal GNSS observations - Zhilu Wu; Yanxiong Liu; Yang Liu; Cuixian Lu; Xiufeng He; Ke Jin; Wenxue Xu (Journal of Geodesy, 2022)

Genetic diversity and population structure of Curcuma alismatifolia Gagnep. accessions revealed by SSR markers - Hui-Wen Yu; Ling-Jun Ke; Yi-Lan Xiao; Si-Jia Chen; Yuan-Yuan Li; Qi-Lin Tian; Yun-He Li; Jin-Shui Lin; Luan-Mei Lu (Genetic Resources and Crop Evolution, 2022)

Probabilistic risk analysis for coal mine gas overrun based on FAHP and BN: a case study - Shan He; Yi Lu; Min Li (Environmental Science and Pollution Research, 2022)

Complete genome analysis of a novel picorna-like virus from a ladybird beetle (Cheilomenes sexmaculata) - Yu-Juan He; Zhuang-Xin Ye; Jian-Ping Chen; Chuan-Xi Zhang; Gang Lu; Jun-Min Li (Archives of Virology, 2022)

Early changes to the extracellular space in the hippocampus under simulated microgravity conditions - Yajuan Gao; Hongbin Han; Jichen Du; Qingyuan He; Yanxing Jia; Junhao Yan; Hui Dai; Bin Cui; Jing Yang; Xunbin Wei; Liu Yang; Rui Wang; et al. (Science China Life Sciences, 2022)

Research on Mechanisms and Precursors of Slip and Fracture of Coal–Rock Parting–Coal Structure - Zhi-Long He; Cai-Ping Lu; Xiu-Feng Zhang; Ying Guo; Chao Wang; Heng Zhang; Bao-Qi Wang (Rock Mechanics and Rock Engineering, 2022)

The role of fine root morphology in nitrogen uptake by riparian plants - Bianhe Lu; Jin Qian; Jing Hu; Peifang Wang; Wen Jin; Sijing Tang; Yuxuan He; Chao Zhang (Plant and Soil, 2022)

Whole genome re-sequencing reveals the genetic diversity and evolutionary patterns of Eucommia ulmoides - Jun Qing; Yi-De Meng; Feng He; Qing-Xin Du; Jian Zhong; Hong-Yan Du; Pan-Feng Liu; Lan-Ying Du; Lu Wang (Molecular Genetics and Genomics, 2022)

Prediction of Nitrogen, Phosphorus, and Potassium Contents in Apple Tree Leaves Based on In-Situ Canopy Hyperspectral Reflectance Using Stacked Ensemble Extreme Learning Machine Model - Shaomin Chen; Tiantian Hu; Lihua Luo; Qiong He; Shaowu Zhang; Junsheng Lu (Journal of Soil Science and Plant Nutrition, 2022)

Combined toxicity of polystyrene microplastics and sulfamethoxazole on zebrafish embryos - Jiarui Lu; Jie Wu; Lulin Gong; Yuan Cheng; Qingbin Yuan; Yide He (Environmental Science and Pollution Research, 2022)

Effects of extreme precipitation on hospitalization risk and disease burden of schizophrenia in urban and rural Lu’an, China, from 2010 to 2019 - Yudong Wu; Zhenghai Yao; Gongyan Ma; Jian Cheng; Huabin Xu; Wei Qin; Weizhuo Yi; Rubing Pan; Qiannan Wei; Chao Tang; Xiangguo Liu; Yangyang He; et al. (Environmental Science and Pollution Research, 2022)

Iodine content of fish otoliths in species found in diverse habitats - Ruliang He; Karin E. Limburg; Benjamin D. Walther; Melvin A. Samson; Zunli Lu (Environmental Biology of Fishes, 2022)

Warming effects on grassland productivity depend on plant diversity - Junjiong Shao; Xuhui Zhou; Kees Jan van Groenigen; Guiyao Zhou; Huimin Zhou; Lingyan Zhou; Meng Lu; Jianyang Xia; Lin Jiang; Bruce A. Hungate; Yiqi Luo; Fangliang He; et al. (Global Ecology and Biogeography, 2022)
Aim Climate warming and biodiversity loss both alter plant productivity, yet we lack an understanding of how biodiversity regulates the responses of ecosystems to warming. In this study, we examine how plant diversity regulates the responses of grassland productivity to experimental warming using meta‐analytic techniques. Location Global. Major taxa studied Grassland ecosystems. Methods Our meta‐analysis is based on warming responses of 40 different plant communities obtained from 20 independent studies on grasslands across five continents. Results Our results show that plant diversity and its responses to warming were the most important factors regulating the warming effects on plant productivity, among all the factors considered (plant diversity, climate and experimental settings). Specifically, warming increased plant productivity when plant diversity (indicated by effective number of species) in grasslands was lower than 10, whereas warming decreased plant productivity when plant diversity was greater than 10. Moreover, the structural equation modelling showed that the magnitude of warming enhanced plant productivity by increasing the performance of dominant plant species in grasslands of diversity lower than 10. The negative effects of warming on productivity in grasslands with plant diversity greater than 10 were partly explained by diversity‐induced decline in plant dominance. Main conclusions Our findings suggest that the positive or negative effect of warming on grassland productivity depends on how biodiverse a grassland is. This may mainly be due to differences in how warming may affect plant dominance and subsequent shifts in interspecific interactions in grasslands of different plant diversity levels.

Risk and protection strategies of Amolops wuyiensis intestine against gastrointestinal nematode ( Cosmocercoides wuyiensis n. sp.) infection - Yilin Shu; Yunyun Xie; Shikun Li; Liming Cai; Ying Liu; Yalin Feng; Jun He; Huijuan Zhang; Menglong Ran; Qina Jia; Hailong Wu; Linming Lu (Environmental Microbiology, 2022)
Summary Anuran amphibians are susceptible to infection by intestinal nematodes, but the damage and response mechanisms that occur in their intestines after infection are only partially understood. In this study, the intestinal disruption and response mechanisms in Amolops wuyiensis frogs infected with Cosmocercoides wuyiensis n. sp. were revealed through analysis of the intestinal histopathology, digestive enzyme activity, transcriptome and intestinal microbiota. Tissue section analysis showed histological damage and inflammation in the infected intestine, and the digestive enzyme activity indicated a decrease in digestion and absorption of some nutrients. We found that infection led to differences in the intestinal microbiota composition, including lower diversity and symbiotic relationships. The greater relative abundance of the genera Burkholderia and Rhodococcus may enhance intestinal immunity to resist pathogenic infections. A comparison of the transcriptomes of infected and uninfected intestines revealed 1055 differentially expressed genes. GO enrichment and KEGG pathways analyses suggested that the guts of infected C . wuyiensis n. sp. show enhanced complement activation, cell adhesion molecule function, NOD‐like receptor signalling pathway activity and other innate immunity responses. Among the adaptive immune responses, the intestinal immune network for IgA production was significantly enriched, and the expression of IL‐17D and transforming growth factor beta‐1 genes were upregulated in the infected intestine. These results imply that C . wuyiens is n. sp. infection of A . wuyiensis intestine may trigger innate and adaptive immune responses, which reduce the post‐infection burden. Furthermore, the intestine of A . wuyiensis may also respond to C . wuyiensis n. sp. infection by increasing metallocarboxypeptidase activity and accelerating smooth muscle contraction.

Four new prenylflavonol glycosides from the leaves of Cyclocarya paliurus - Zi-Jun Ye; Hui-Hui Sun; Zu-Hui Chen; Jian-Ping Wu; Jing Li; Hui Zhu; Lu-Lu Huang; Xi-Wen Chang; Sai-Yu Ou; Wen-Xuan Wang; Xiao-Ai He; Gang-Zhi Zhu; et al. (Natural Product Research, 2022)

Cancer metabolism and tumor microenvironment: fostering each other? - Yiyuan Yuan; Huimin Li; Wang Pu; Leilei Chen; Dong Guo; Hongfei Jiang; Bo He; Siyuan Qin; Kui Wang; Na Li; Jingwei Feng; Jing Wen; et al. (Science China Life Sciences, 2022)

Interfering TUG1 Attenuates Cerebrovascular Endothelial Apoptosis and Inflammatory injury After Cerebral Ischemia/Reperfusion via TUG1/miR-410/FOXO3 ceRNA Axis - Zhirong He; Yanyan Zhao; Yongxia Zhu; Weihua Wang; Xin Liu; Fen Lu (Neurotoxicity Research, 2022)

Asperity Degradation Characteristics and Mechanical Behavior of Rock Joints Subjected to Pre-peak Cyclic Loading - Liu He; Zhiming Zhao; Lang Liu; Xudong Lu (Geotechnical and Geological Engineering, 2022)

Prediction and validation of cross-protective candidate antigen of Hyalomma asiaticum cathepsin L between H. asiaticum and H. anatolicum - Ruiqi Song; Xuejie Zhai; Xinli Fan; Yongchang Li; Huercha; Ting Ge; Caishan Li; Min Li; Wenwen He; Huizhen Zheng; Lu Gan; Yang Zhang; et al. (Experimental and Applied Acarology, 2022)

The association between short-term ambient air pollution and acne vulgaris outpatient visits: a hospital-based time-series analysis in Xi’an - Xiang Li; Yi Cao; Shu-Jie An; Ying Xiang; He-Xiang Huang; Bin Xu; Yao Zhang; Ya-Fei Li; Yuan-Gang Lu; Tong-Jian Cai (Environmental Science and Pollution Research, 2022)

The associations between organophosphate esters and urinary incontinence in the general US population - Mingjing He; Kun Jin; Shi Qiu; Xinyang Liao; Xiaonan Zheng; Zeyu Chen; Jianzhong Ai; Lu Yang; Zhongyuan Jiang; Dan Hu; Qiang Wei (Environmental Science and Pollution Research, 2022)
Organophosphate esters (OPEs) impact health in many ways. Since its relationship with urinary incontinence remains unknown, we aimed to explore their associations in the US general population. We combined the results of urine specimens test and self-reported urinary incontinence conditions from the National Health and Nutrition Examination Survey (NHANES) 2013–2014 among 2666 participants and then conducted linear regression and logistic regression to analyse associations between log2-transformed OPE concentrations and urinary incontinence. We found that 0.92% of men and 15.74% of women complained of mixed urinary incontinence (MUI). The concentrations of diphenyl phosphate (DPHP) were significantly correlated to MUI among women when treated as a continuous variable (adjusted odds ratio (OR) = 1.15; 95% confidence interval (CI), 1.01–1.31; p = 0.0369) and as a categorical variable (adjusted OR = 1.24; 95% CI, 1.03–1.49; p for trend = 0.0245), whereas no positive correlation was found in males. There were no significant associations between the other three OPEs: bis(2-chloroethyl) phosphate (BCEP), bis(1,3-dichloro-2-propyl) phosphate (BDCPP) and dibutyl phosphate (DBUP). The association of DPHP with an increased prevalence OR of MUI in women is a public health concern; future prospective studies are needed to explore its potential mechanism.

Influence of epileptogenic region on brain structural changes in Rolandic epilepsy - Yin Xu; Qiang Xu; Qirui Zhang; Steven M. Stufflebeam; Fang Yang; Yan He; Zheng Hu; Yifei Weng; Junhao Xiao; Guangming Lu; Zhiqiang Zhang (Brain Imaging and Behavior, 2022)

Identification and expression analysis of grape LRK10L-2 genes during grape fruit development - Jin-Ping Ma; Xue-Ren Yin; Tong-Lu Wei; Hai-Nan Liu; Mao-Song Pei; Sheng-Di Yang; Hui-Ying Jin; Guang-Qi He; Da-Long Guo (Plant Biotechnology Reports, 2022)

Improved pinene production in a recombinant yeast by fusion linker optimization and chaperon coexpression - Quanlu Ren; Yaxi He; Xinyao Lu; Hong Zong; Bin Zhuge (Systems Microbiology and Biomanufacturing, 2022)

Genomic polymorphisms at the crhr2 locus improve feed conversion efficiency through alleviation of hypothalamus-pituitary-interrenal axis activity in gibel carp (Carassius gibelio) - Chuang Shi; Qiyong Lou; Beide Fu; Junyan Jin; Jianfei Huang; Yao Lu; Xia Jin; Jiangyan He; Gang Zhai; Shouqi Xie; Jingou Tong; Jianfang Gui; et al. (Science China Life Sciences, 2022)

Geographical distinctions of longevity indicators and their correlation with climatic factors in the area where most Chinese Yao are distributed - Huaxiang Lu; Haoyu He; Qiumei Liu; Jiansheng Cai; Chunbao Mo; Shuzhen Liu; Shiyi Chen; Xia Xu; Xu Tang; Jian Qin; Zhiyong Zhang (International Journal of Biometeorology, 2022)

Retraction Note to: Revisiting the male genetic landscape of China: a multi-center study of almost 38,000 Y-STR haplotypes - Michael Nothnagel; Guangyao Fan; Fei Guo; Yongfeng He; Yiping Hou; Shengping Hu; Jiang Huang; Xianhua Jiang; Wook Kim; Kicheol Kim; Chengtao Li; Hui Li; et al. (Human Genetics, 2022)

PCDD/F removal at low temperatures over vanadium-based catalyst: insight into the superiority of mechanochemical method - Minghui Tang; Qiulin Ye; Cuicui Du; Yaqi Peng; Chengetai Portia Makwarimba; Yao He; Shengyong Lu (Environmental Science and Pollution Research, 2022)

Geochemical characteristics and origin of Chang-9 crude oil of Triassic Yanchang Formation in Zhidan area, Ordos Basin, China - Zhengyu Wu; Shijia Chen; Chengshan Li; Jian Yu; Yibo Chang; Zixing Lu; Xin He; Haifeng Zhang; Han Meimei (Arabian Journal of Geosciences, 2022)

Overview of the Processes Driving Exchange at Cape Hatteras Program - Harvey Seim; Dana Savidge; Magdalena Andres; John Bane; Catherine Edwards; Glen Gawarkiewicz; Ruoying He; Robert Todd; Michael Muglia; Joseph Zambon; Lu Han; Shun Mao (Oceanography, 2022)
The Processes driving Exchange At Cape Hatteras (PEACH) program seeks to better understand seawater exchanges between the continental shelf and the open ocean near Cape Hatteras, North Carolina. This location is where the Gulf Stream transitions from a boundary-trapped current to a free jet, and where robust along-shelf convergence brings cool, relatively fresh Middle Atlantic Bight and warm, salty South Atlantic Bight shelf waters together, forming an important and dynamic biogeographic boundary. The magnitude of this convergence implies large export of shelf water to the open ocean here. Background on the oceanography of the region provides motivation for the study and gives context for the measurements that were made. Science questions focus on the roles that wind forcing, Gulf Stream forcing, and lateral density gradients play in driving exchange. PEACH observational efforts include a variety of fixed and mobile observing platforms, and PEACH modeling included two different resolutions and data assimilation schemes. Findings to date on mean circulation, the nature of export from the southern Middle Atlantic Bight shelf, Gulf Stream variability, and position variability of the Hatteras Front are summarized, together with a look ahead to forthcoming analyses.

Circ_0002711 knockdown suppresses cell growth and aerobic glycolysis by modulating miR-1244/ROCK1 axis in ovarian cancer - Weiquan Xie; Lu Liu; Chuanyong He; Min Zhao; Rong Ni; Zixiong Zhang; Chengyu Shui (Journal of Biosciences, 2021)

Full waveform inversion based on deep learning and optimal nearly analytic discrete method - Lu Fan; Zhou Yan-Jie; He Xi-Jun; Ma Xiao; Huang Xue-Yuan (Applied Geophysics, 2021)

The chemical profile and biological activity of different extracts of Sapindus mukorossi Gaertn. against Cutibacterium acnes - Min-Ping Wei; Jin-Dan Qiu; Lu Li; Yun-Fei Xie; Ya-Hui Guo; Hang Yu; Yu-Liang Cheng; He Qian; Wei-Rong Yao (Natural Product Research, 2021)

Isolation of evolvulic acids B and C, two new components of crude resin glycoside fraction from Evolvulus alsinoides - Jin-Yuan Xu; Ye He; Ai-Wen Zhang; Yun Lu; Guang-Tong Chen; Min Yang; Bo-Yi Fan (Natural Product Research, 2021)

Leaching alleviates phenol-mediated root rot in Panax notoginseng by modifying the soil microbiota - Yijie Zhang; Tianyao Li; Chen Ye; Renchuang Lu; Yixiang Liu; Huichuan Huang; Xiahong He; Min Yang; Shusheng Zhu (Plant and Soil, 2021)

Dopaminergic Projection from Ventral Tegmental Area to Substantia Nigra Pars Reticulata Mediates Chronic Social Defeat Stress–Induced Hypolocomotion - Feng He; Pei Zhang; Qian Zhang; Guangjian Qi; Hongwei Cai; Tongxia Li; Ming Li; Jiazhen Lu; Jiaen Lin; Jie Ming; Bo Tian (Molecular Neurobiology, 2021)

Heat stress inhibits TLR4-NF-κB and TLR4-TBK1 signaling pathways in broilers infected with Salmonella Typhimurium - Wei-Hao Li; Yi-Lei Liu; Jian-Chi Lun; Yong-Ming He; Lu-Ping Tang (International Journal of Biometeorology, 2021)
With the global warming, the harm of heat stress (HS) to the breeding industry has become more common, which causes the decline of animal production performance and low immunity. This study aimed to analyze the effect of HS on the intestinal immune function of Salmonella- infected chickens. Fourteen-day-old broilers were divided into the following four groups of eight replicates: control (Control), heat stress (HS), Salmonella Typhimurium (ST), and heat stress + Salmonella Typhimurium (HS+ST). The broilers were subjected to a heat stress of 35 °C from 15 to 28 days of age. Salmonella Typhimurium (ST, 14028, 10 9 cfu/mL) was inoculated, via oral administration at 29 days of age, into ST and HS+ST group birds. On the 4th day after Salmonella Typhimurium administration, an increase in jejunum IgA levels was observed in chickens infected with Salmonella Typhimurium. Mechanistic regulation of TLR4-NFκB-NLRP3 and TLR4-TBK1 signaling by heat stress was evaluated in Salmonella Typhimurium–infected broilers. Heat stress markedly inhibited the expression of cytokines including TNF-α, IL-6, IL-1β, NLRP3, caspase-1, NF-κB-p65, and p-NF-κB-p65, and the TLR4-TBK1 cytokines IFN-α, IFN-γ, p-IRF3, and p-TBK1 in jejunum of broilers infected with Salmonella Typhimurium. Collectively, our results demonstrate that heat stress can inhibit intestinal immune response by downregulating the expression of TLR4-NFκB-NLRP3 and TLR4-TBK1 signaling pathways in broilers infected with Salmonella Typhimurium.

Deciphering the rhizobacterial assemblages under the influence of genetically engineered maize carrying mcry genes - Aliya Fazal; Zhongling Wen; Minkai Yang; Yonghui Liao; Jiangyan Fu; Cong He; Xuan Wang; Wencai Jie; Farman Ali; Dongqing Hu; Tongming Yin; Zhi Hong; et al. (Environmental Science and Pollution Research, 2021)

Design and Characterization of HY-038 Solid Dispersions via Spray Drying Technology: In Vitro and In Vivo Evaluations - Taotao Jiang; Limei Han; Enhao Lu; Wenxiu He; Shilin Du; Xianyi Sha (AAPS PharmSciTech, 2021)

Vanillic acid combats Vibrio alginolyticus by cell membrane damage and biofilm reduction - Huan Liu; Miao Xiao; Jing Zuo; Xiaoxian He; Ping Lu; Yingyu Li; Yanni Zhao; Fei Xia (Journal of Fish Diseases, 2021)
Antibiotics are the most powerful weapon against bacterial infectious diseases in aquaculture. However, the indiscriminate usage of antibiotics often culminates in the emerging development of antibiotic‐resistant bacteria, making it imperative to search for novel types of antimicrobial agents. This study investigated the antibacterial and antivirulence effects of vanillic acid (VA) against the fish pathogen, Vibrio alginolyticus . We showed that VA had a good anti‐ Vibrio activity with minimal inhibitory concentration (MIC) of 1.0 mg/ml. In addition, VA wielded its antibacterial action in a dose‐/time‐dependent manner by causing cell membrane damage and increasing membrane permeability, which is evidenced by increasing the conductivity and malondialdehyde content in the treated cell cultures and the scanning electron microscopy images. Furthermore, VA significantly reduced the biofilm‐forming capability, mobility and exotoxin production (protease and exopolysaccharide) and downregulation of the expression of biofilm‐ and virulence‐associated genes ( sypG , fliS , fliK , lafA , lafK , asp and luxR ) was seen in the V. alginolyticus that exposed to VA at subinhibitory concentrations. Overall, our findings suggested that VA may be of interest for treating V. alginolyticus ‐associated infections in aquaculture.

Sedimentary Environmental Evolution of the Western Taiwan Shoal Area since the Late Pleistocene - Chipeng He; Longbin Sha; Dongbo Zhao; Lu Dai; Zheng Li; Jiabing Tang; Xianfu Li; Dongling Li (Journal of Marine Science and Engineering, 2021)
A new pollen analysis and major and trace element contents were conducted on a 40 m long gravity core recovered from the Taiwan Shoal (sand ridges), south of the Taiwan Strait, beginning in the Late Pleistocene. The changes in the pollen assemblage and concentration represent the climate change around the Taiwan Shoal and the strength of the Zhe-Min Coastal Current, whereas variations in major and trace element contents can imply the source of the sediments in the Taiwan Shoal, which are correlated with the rise or fall of the sea level with increased marine dinoflagellate cysts. The interval of 40–30 m was characterized by high pollen and spore concentrations, and evergreen Quercus was dominant taxon, which indicates a warm sedimentary environment, and the surrounding area of the Taiwan Shoal were covered by a tropical and subtropical broad-leaved forest. There were no pollen and spores from 30–24 m, which indicates a strong hydrodynamic sedimentary environment, and most of the Taiwan Shoal might have been experience subaerial exposure. The interval of 24–17 m was characterized by the reappearance of pollen and spores, as well as marine dinoflagellate cysts and foraminifera, suggesting the climate was warm and wet in the study area and an apparent marine sedimentary environment with relatively high sea level. Deciduous Quercus dominated the interval of 17–12 m, which indicated that the climate was relatively cool, corresponding to the end of Marine isotope stages3 (MIS3) to the Last Glacial Maximum accompanied by weathering and denudation. Above 12 m, the low pollen concentration with increased marine dinoflagellate cysts and foraminifera abundance suggested a marine sedimentary environment in the Taiwan Shoal. The high concentrations in Pinus corresponds to Holocene high sea level.

Peripheral CD4+ T cell signatures in predicting the responses to anti-PD-1/PD-L1 monotherapy for Chinese advanced non-small cell lung cancer - Liliang Xia; Hui Wang; Mingjiao Sun; Yi Yang; Chengcheng Yao; Sheng He; Huangqi Duan; Weimin Xia; Ruiming Sun; Yaxian Yao; Zhiwei Chen; Qiong Zhao; et al. (Science China Life Sciences, 2021)

Mycorrhization of Quercus mongolica seedlings by Tuber melanosporum alters root carbon exudation and rhizosphere bacterial communities - Yanliang Wang; Ran Wang; Bin Lu; Alexis Guerin-Laguette; Xinhua He; Fuqiang Yu (Plant and Soil, 2021)

Improving Tight Gas Recovery from Multi-pressure System During Commingled Production: An Experimental Investigation - Lu Wang; Yongming He; Qian Wang; Mingming Liu; Xin Jin (Natural Resources Research, 2021)

Metabolic responses of Chinese perch (Siniperca chuatsi) to different levels of dietary carbohydrate - Yanpeng Zhang; Xu-fang Liang; Shan He; Jie Wang; Ling Li; Zhen Zhang; Jiao Li; Xu Chen; Lu Li; Muhammad Shoaib Alam (Fish Physiology and Biochemistry, 2021)

Elastin-like polypeptide and γ-zein fusions significantly increase recombinant protein accumulation in soybean seeds - Jing Yang; HongWei Xun; Lu Niu; Hongli He; Yunqing Cheng; Xiaofang Zhong; Qianqian Zhao; Guojie Xing; Jianfeng Liu; Xiangdong Yang (Transgenic Research, 2021)

Landslides Triggered by the 2020 Qiaojia Mw5.1 Earthquake, Yunnan, China: Distribution, Influence Factors and Tectonic Significance - Xiangli He; Chong Xu; Wenwen Qi; Yuandong Huang; Jia Cheng; Xiwei Xu; Qi Yao; Yongkun Lu; Boyang Dai (Journal of Earth Science, 2021)

Interactive effects of nutrient availability, fluctuating supply, and plant parasitism on the post-invasion success of Bidens pilosa - Fang-Lei Gao; Qiao-Sheng He; Ru-Qian Xie; Jia-Hui Hou; Chen-Lu Shi; Jun-Min Li; Fei-Hai Yu (Biological Invasions, 2021)

Optimized Doppler Estimation and Symbol Synchronization for Mobile M-ary Spread Spectrum Underwater Acoustic Communication - Guang Yang; Feng Zhou; Gang Qiao; Yunjiang Zhao; Yufei Liu; Yinheng Lu; Yuanan He (Journal of Marine Science and Engineering, 2021)
In mobile underwater acoustic (UWA) communications, the Doppler effect causes severe signal distortion, which leads to carrier frequency shift and compresses/broadens the signal length. This situation has a more severe impact on communication performance in the case of low signal-to-noise ratio and variable-speed movement. This paper proposes a non-data-aided Doppler estimation method for M-ary spread spectrum UWA communication systems in mobile scenarios. The receiver uses the spread spectrum codes dedicated to transmitting signals with different frequency offsets as local reference signals. Correlation operations are performed symbol by symbol with the received signal. The decoding and Doppler estimation of the present symbol are achieved by searching the correlation maximum in the code domain and frequency domain. The length of the current symbol is corrected for the next symbol synchronization using the estimated Doppler coefficient. To optimize the process of Doppler estimation and symbol synchronization, a heuristic search method is used. By adjusting the Doppler factor search step size, setting the threshold value, and using the Doppler factor estimation of the previous symbol, the search range can be significantly reduced and the computational complexity decreased. The Fisher-Yates shuffle algorithm is used to traverse the search range to ensure reliability of the results. Simulation results show that enlarging the frequency-domain search step size in some degree does not affect the decoding accuracy. On 15 May 2021, a shallow-water mobile UWA spread spectrum communication experiment was conducted in Weihai, China. The horizontal distance between the transmitter and the receiver is 3.7–4.0 km, and the communication rate is 41.96 bits per second. The transmitting ship moves at a speed of 0–3 m/s, and the bit error rate (BER) is lower than 1e−3, which is better than that of the sliding correlation despreading method with average Doppler compensation.

Purple non-sulfur bacteria technology: a promising and potential approach for wastewater treatment and bioresources recovery - Haifeng Lu; Guangming Zhang; Shichao He; Ruihan Zhao; Da Zhu (World Journal of Microbiology and Biotechnology, 2021)

Genetic control and phenotypic characterization of panicle architecture and grain yield-related traits in foxtail millet (Setaria italica) - Hui Zhi; Qiang He; Sha Tang; Junjun Yang; Wei Zhang; Huifang Liu; Yanchao Jia; Guanqing Jia; Aiying Zhang; Yuhui Li; Erhu Guo; Ming Gao; et al. (Theoretical and Applied Genetics, 2021)

High-resolution genome-wide association study and genomic prediction for disease resistance and cold tolerance in wheat - Yunlong Pang; Yuye Wu; Chunxia Liu; Wenhui Li; Paul St. Amand; Amy Bernardo; Danfeng Wang; Lei Dong; Xiufang Yuan; Huirui Zhang; Meng Zhao; Linzhi Li; et al. (Theoretical and Applied Genetics, 2021)

Bone marrow mesenchymal stem cell-derived exosomes induce the Th17/Treg imbalance in immune thrombocytopenia through miR-146a-5p/IRAK1 axis - Yue He; Dexiang Ji; Wei Lu; Fei Li; Xianbao Huang; Ruibin Huang; Guoan Chen (Human Cell, 2021)

Research progress in bioremediation of petroleum pollution - Yong Yang; Zhan-Wei Zhang; Rui-Xia Liu; Hai-Yan Ju; Xue-Ke Bian; Wan-Ze Zhang; Chuan-Bo Zhang; Ting Yang; Bing Guo; Chen-Lei Xiao; He Bai; Wen-Yu Lu (Environmental Science and Pollution Research, 2021)

Assembly and variation of root-associated microbiota of rice during their vegetative growth phase with and without lindane pollutant - Jiayin Feng; Ashley E. Franks; Zhijiang Lu; Jianming Xu; Yan He (Soil Ecology Letters, 2021)

Fracture Extraction from Smooth Rock Surfaces Using Depth Image Segmentation - Yudi Tang; Lei He; Huaiguang Xiao; Ruihua Wang; Wei Lu; Tao Xu (Rock Mechanics and Rock Engineering, 2021)

An integrated transcriptome and metabolome approach reveals the accumulation of taste-related metabolites and gene regulatory networks during watermelon fruit development - Chengsheng Gong; Hongju Zhu; Xuqiang Lu; Dongdong Yang; Shengjie Zhao; Muhammad Jawad Umer; Nan He; Pingli Yuan; Muhammad Anees; Weinan Diao; M. O. Kaseb; Wenge Liu (Planta, 2021)

Porous Materials Prepared by Magnesium Phosphate Cement for the Effective Immobilization of Lead Ions - Wu Jie; Lai Zhenyu; He Xin; Yan Tao; Liu Mengliang; Deng Qiubai; Khan Khalid; Lu Zhongyuan; Lv Shuzhen (International Journal of Environmental Research, 2021)

The comparative impact among different intensive statins and combination therapies with niacin/ezetimibe on carotid intima-media thickness: a systematic review, traditional meta-analysis, and network meta-analysis of randomized controlled trials - Hongwei Li; Xiaolin Xu; Liming Lu; Runlu Sun; Qi Guo; Qian Chen; Junjie Wang; Zhijian He; Yuling Zhang (European Journal of Clinical Pharmacology, 2021)

X anthium Orientale subsp . Italicum (Moretti) Greuter : bioassay-guided isolation and its chemical basis of antitumor cytotoxicity - Yuan He; Dongyu Lei; Qingqing Yang; Hao Qi; Kurax Almira; Dilnigar Askar; Lu Jin; Le Pan (Natural Product Research, 2021)

Arvensic acids K and L, components of resin glycoside fraction from Convolvulus arvensis - Yun Lu; Ye He; Min Yang; Bo-Yi Fan (Natural Product Research, 2021)

Research on Improving the Working Efficiency of Hydraulic Jet Submarine Cable Laying Machine - Zhifei Lu; Chen Cao; Yongqiang Ge; Jiamin He; Zhou Yu; Jiawang Chen; Xinlong Zheng (Journal of Marine Science and Engineering, 2021)
The anchoring and hooking of ships, bedrock friction and biological corrosion threaten the safety and stability of submarine cables. A hydraulic jet submarine cable laying machine manages to bury the submarine cables deep into the seabed, and effectively reduces the occurrence of external damage to the submarine cables. This machine uses a hydraulic jet system to realize trenching on the seabed. However, the hydraulic jet submarine cable laying machine has complicated operation and high power consumption with high requirements on the mother ship, and it is not yet the mainstream trenching method. In this paper, a mathematical model for the hydraulic jet nozzle of the submarine cable laying machine is established, and parameters that affect the trenching efficiency are studied. The effects of jet target distance, flow, angle and nozzle spacing on the working efficiency of the burying machine are analyzed by setting up a double-nozzle model. The results of the theory, numerical simulation and experiment show that the operational efficiency of the hydraulic jet submarine cable laying machine can be distinctly improved by setting proper jet conditions and parameters.

Vitamin D status and vitamin D receptor genotypes in celiac disease: a meta-analysis - Chao Lu; Weihua Zhou; Xinjue He; Xinxin Zhou; Chaohui Yu (Critical Reviews in Food Science and Nutrition, 2021)

Identification of a delayed leaf greening gene from a mutation of pummelo - Hui-Wen Yu; Zhi-Hao Lu; Xia Wang; Dan Liu; Jia-Xian He; Xiao-Lin Jiang; Ling-Jun Ke; Wen-Wu Guo; Xiu-Xin Deng; Qiang Xu (Science China Life Sciences, 2021)

Oral Treponema denticola Infection Induces Aβ1–40 and Aβ1–42 Accumulation in the Hippocampus of C57BL/6 Mice - Xinyi Su; Zhiqun Tang; Zhiyue Lu; Yuqiu Liu; Wanzhi He; Jiapei Jiang; Yifan Zhang; Hongkun Wu (Journal of Molecular Neuroscience, 2021)

Phytoavailability, translocation and soil thresholds derivation of cadmium for food safety through soil-wheat (Triticum aestivum L.) system - Min Lu; Xuerui Cao; Qiang Lin; Bilal Hussain; Ying Feng; Zhenli He; Kyong Ju Kang; Xiaoe Yang (Environmental Science and Pollution Research, 2021)

Dissolved phosphorus export through baseflow in an intensively cultivated agricultural watershed of eastern China - Shengjia He; Jun Lu (Environmental Science and Pollution Research, 2021)

Retrospective surveillance of porcine circovirus 4 in pigs in Inner Mongolia, China, from 2016 to 2018 - Zhuo Ha; Chengdong Yu; Changzhan Xie; Guanyu Wang; Ying Zhang; Pengfei Hao; Jinfeng Li; Zhuoxin Li; Yanwei Li; Fulong Rong; Fulong Nan; He Zhang; et al. (Archives of Virology, 2021)

Latitudinal patterns of terrestrial phosphorus limitation over the globe - Enqing Hou; Dazhi Wen; Lifen Jiang; Xianzhen Luo; Yuanwen Kuang; Xiankai Lu; Chengrong Chen; Keanan T. Allen; Xianjin He; Xingzhao Huang; Yiqi Luo (Ecology Letters, 2021)
Phosphorus limitation on terrestrial plant growth is being incorporated into Earth system models. The global pattern of terrestrial phosphorus limitation, however, remains unstudied. Here, we examined the global‐scale latitudinal pattern of terrestrial phosphorus limitation by analysing a total of 1068 observations of aboveground plant production response to phosphorus additions at 351 forest, grassland or tundra sites that are distributed globally. The observed phosphorus‐addition effect varied greatly (either positive or negative), depending significantly upon fertilisation regime and production measure, but did not change significantly with latitude. In contrast, phosphorus‐addition effect standardised by fertilisation regime and production measure was consistently positive and decreased significantly with latitude. Latitudinal gradient in the standardised phosphorus‐addition effect was explained by several mechanisms involving substrate age, climate, vegetation type, edaphic properties and biochemical machinery. This study suggests that latitudinal pattern of terrestrial phosphorus limitation is jointly shaped by macro‐scale driving forces and the fundamental structure of life.

A survey of chloramphenicol residues in aquatic products of Shenzhen, South China - Lan Luo; Shaoyou Lu; Chengpeng Huang; Fu Wang; Yan Ren; He Cao; Qihui Lin; Zhiqiang Tan; Xiaodong Wen (Food Additives & Contaminants: Part A, 2021)

Numerical Study of the Pulsation Process of Spark Bubbles under Three Boundary Conditions - Chunlong Ma; Dongyan Shi; Chao Li; Dongze He; Guangliang Li; Keru Lu (Journal of Marine Science and Engineering, 2021)
In this study, a compressible three-phase homogeneous model was established using ABAQUS/Explicit. These models can numerically simulate the pulsation process of cavitation bubbles in the free field, near the flat plate target, and near the curved boundary target. At the same time, these models can numerically simulate the strong nonlinear interaction between the cavitation bubble and its nearby wall boundaries. The mutual flow of liquid and gas and fluid solid coupling were solved by the Euler domain in simulation. The results of the numerical simulation were verified by comparing them with the experimental results. In this study, we used electric spark bubbles to represent cavitation bubbles. A high-speed camera was used to record the pulsation process of cavitation bubbles. This study first verified the pulsation process of cavitation bubbles in the free field, because it was the simplest case. Then we verified the interaction process between cavitation bubbles and different wall boundaries. In order to further confirm the credibility of the numerical simulation results, for each wall surface, this study used two burst distances (10 mm and 25 mm) for simulation verification. The numerical model established in this study could effectively simulate the pulsation characteristics of cavitation bubbles, such as the formation of jets and annular bubbles. After verification, the simulated cavitation bubble was almost the same as the cavitation bubble captured by the high-speed camera in the experiment in terms of time, volume, and shape. In this study, a detailed velocity field of the cavitation bubble collapse stage was obtained, which laid down the foundation for the study of the strong nonlinear interaction between the cavitation bubble and the target plates of different shapes. Compared with the experimental results, we found that the numerical model established by the simulation could accurately simulate the bubble pulsation and jet formation processes. In the experiment, the interval time for the bubble pictures taken by the high-speed camera was 41.66 μs per frame. Using a numerical model, the bubble pulsation process can be simulated at an interval of 1 µs per frame. Therefore, the numerical model established by the simulation could show the movement characteristics of the cavitation bubble pulsation process in more detail.

Multi-proxy evidence of environmental change related to collapse of the Liangzhu Culture in the Yangtze Delta, China - Keyang He; Houyuan Lu; Guoping Sun; Xiang Ji; Yonglei Wang; Kaikai Yan; Xinxin Zuo; Jiangping Zhang; Bin Liu; Ningyuan Wang (Science China Earth Sciences, 2021)

Genetic Architecture of Childhood Kidney and Urological Diseases in China - Ye Fang; Hua Shi; Tianchao Xiang; Jiaojiao Liu; Jialu Liu; Xiaoshan Tang; Xiaoyan Fang; Jing Chen; Yihui Zhai; Qian Shen; Guomin Li; Li Sun; et al. (Phenomics, 2021)
Kidney disease is manifested in a wide variety of phenotypes, many of which have an important hereditary component. To delineate the genotypic and phenotypic spectrum of pediatric nephropathy, a multicenter registration system is being implemented based on the Chinese Children Genetic Kidney Disease Database (CCGKDD). In this study, all the patients with kidney and urological diseases were recruited from 2014 to 2020. Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features. The genetic diagnosis was confirmed in 883 of 2256 (39.1%) patients from 23 provinces in China. Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome (SRNS, 23.5%), glomerulonephritis (GN, 32.2%), congenital anomalies of the kidney and urinary tract (CAKUT, 21.2%), cystic renal disease (3.9%), renal calcinosis/stone (3.6%), tubulopathy (9.7%), and chronic kidney disease of unknown etiology (CKDu, 5.8%). The pathogenic variants of 105 monogenetic disorders were identified. Ten distinct genomic disorders were identified as pathogenic copy number variants (CNVs) in 11 patients. The diagnostic yield differed by subgroups, and was highest in those with cystic renal disease (66.3%), followed by tubulopathy (58.4%), GN (57.7%), CKDu (43.5%), SRNS (29.2%), renal calcinosis /stone (29.3%) and CAKUT (8.6%). Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions. We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed. Our data demonstrate the utility of family-based exome sequencing, and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease.

Occurrence, spatial distribution, source, and ecological risk assessment of organochlorine pesticides in Dongting Lake, China - Fengmei Cao; Zhaozhao Li; Qi He; Shaoyong Lu; Pan Qin; Linlin Li (Environmental Science and Pollution Research, 2021)

Optimizing the system-wide layout of sewage treatment plants based on enumeration and the orthogonal test - Jiandong Tian; Longyuan Lu; Guifang He (Environmental Science and Pollution Research, 2021)

LAI scale effect research based on compact airborne spectrographic imager data in the Heihe Oasis - Xiao-ai Dai; Chao Liu; Nai-wen Li; Mei-lian Wang; Yu-wei Yang; Xing-ping Yang; Shi-qi Zhang; Xu-wei He; Zheng-li Yang; Heng Lu; Jing-zhong Li; Ze-kun Wang (Journal of Mountain Science, 2021)

Spatio-temporal Variations of Sea Surface Wind in Coral Reef Regions over the South China Sea from 1988 to 2017 - Xin He; Zhenghua Chen; Yongqiang Lu; Wei Zhang; Kefu Yu (Chinese Geographical Science, 2021)

Molecular surveillance of coxsackievirus A16 in southern China, 2008–2019 - Lina Yi; Hanri Zeng; Huanying Zheng; Jinju Peng; Xue Guo; Leng Liu; Qianling Xiong; Limei Sun; Xiaohua Tan; Jianfeng He; Jing Lu; Hui Li (Archives of Virology, 2021)

Temporal and spatial variations of the air temperature in the Taklamakan Desert and surrounding areas - Alim Abbas; Lili Jin; Qing He; Bo Lu; Junqiang Yao; Zhenjie Li; Akida Salam (Theoretical and Applied Climatology, 2021)

Strength Characteristics and Failure Mechanism of a Columnar Jointed Rock Mass Under Uniaxial, Triaxial, and True Triaxial Confinement - Wenbin Lu; Zhende Zhu; Yanxin He; Xiangcheng Que (Rock Mechanics and Rock Engineering, 2021)

Synchronized research on endothelial dysfunction and microcirculation structure in dorsal skin of rats with type 2 diabetes mellitus - Yajie Wei; Huimin Chen; Qingzhuo Chi; Ying He; Lizhong Mu; Chao Liu; Yunxia Lu (Medical & Biological Engineering & Computing, 2021)

Bjerkandera adusta M1 inhibits the growth of Fusarium oxysporum f. sp. conglutinans and fusarium wilt incidence in Brassica napus L. - Xiao Feng; Su-Ping Li; Yi-Fan Lu; Jing-Jie Zhang; Yun-Yun Zhu; Yong Li; Hong-Jun Yang; Xin-Hua He (Journal of Plant Pathology, 2021)

Small-sized extracellular vesicles (EVs) derived from acute myeloid leukemia bone marrow mesenchymal stem cells transfer miR-26a-5p to promote acute myeloid leukemia cell proliferation, migration, and invasion - Dexiang Ji; Yue He; Wei Lu; Yanyan Rong; Fei Li; Xianbao Huang; Ruibin Huang; Yanxia Jiang; Guoan Chen (Human Cell, 2021)

Selective Ferroptosis Inhibitor Liproxstatin-1 Attenuates Neurological Deficits and Neuroinflammation After Subarachnoid Hemorrhage - Yang Cao; Yin Li; Chao He; Feng Yan; Jian-Ru Li; Hang-Zhe Xu; Jian-Feng Zhuang; Hang Zhou; Yu-Cong Peng; Xiong-Jie Fu; Xiao-Yang Lu; Yuan Yao; et al. (Neuroscience Bulletin, 2021)

Glycogen synthase kinase-3β (GSK-3β) deficiency inactivates the NLRP3 inflammasome-mediated cell pyroptosis in LPS-treated periodontal ligament cells (PDLCs) - Xiaolu Zhang; Shan He; Wanyu Lu; Lijia Lin; Hui Xiao (In Vitro Cellular & Developmental Biology - Animal, 2021)

Altered white matter structural networks in drug-naïve patients with obsessive-compulsive disorder - Cong Zhou; Liangliang Ping; Wei Chen; Mengxin He; Jian Xu; Zonglin Shen; Yi Lu; Binli Shang; Xiufeng Xu; Yuqi Cheng (Brain Imaging and Behavior, 2021)

Alpha 1-antichymotrypsin may be a biomarker for the progression of amnestic mild cognitive impairment - Shunjie Liu; Junhao Pan; Ke Tang; Qingfeng Lei; Lu He; Xiaodong Cai; Zhong Li (Acta Neurologica Belgica, 2021)

Cracking Characteristics of the Surrounding Rocks of a Hydraulic Tunnel Under High Geothermal Conditions: A Model Test - Lifeng Peng; Xiaochuan Hu; Guoshao Su; Zihua Qin; He Lu; Baoyu He (Rock Mechanics and Rock Engineering, 2021)

Peanut preinoculation with a root endophyte induces plant resistance to soil-borne pathogen Fusarium oxysporum via activation of salicylic acid-dependent signaling - Kai Sun; Xing-Guang Xie; Fan Lu; Feng-Min Zhang; Wei Zhang; Wei He; Chuan-Chao Dai (Plant and Soil, 2021)

The long-term effects of thinning and mixing on species and structural diversity of Chinese fir plantations - Yuanfa Li; Ji’an He; Lihua Lu; Junmo Xu; Hongxiang Wang; Shaoming Ye (New Forests, 2021)

Emergency response to the reactivated Aniangzhai landslide resulting from a rainstorm-triggered debris flow, Sichuan Province, China - Bo Zhao; Haiquan Zhang; Liao Hongjian; Weile Li; Lijun Su; Wenxiu He; Lu Zeng; Haokun Qin; Megh Raj Dhital (Landslides, 2021)

High-Level Expression and Purification of Melittin in Escherichia coli Using SUMO Fusion Partner - Qiu-chi Chen; Lei Liu; Tian-Yi Yu; Lu Tang; Mo-li Yin; Wen-he Zhu; Xiu-yun Jiang; Hui-yan Wang (International Journal of Peptide Research and Therapeutics, 2021)

SH2 domain-containing protein tyrosine phosphatase-2 (SHP-2) prevents cardiac remodeling after myocardial infarction through ERK/SMAD signaling pathway - Yong-Gang Lu; He Tan; Qian Ma; Xin-Xin Li; Jia Cui; Xue Zhang; Xue-Lei Liang; Yan-Qing Tie (Human Cell, 2021)

Conservation planning of the genus Rhododendron in Northeast China based on current and future suitable habitat distributions - Yupeng Lu; Huanchu Liu; Wei Chen; Jing Yao; Yanqing Huang; Yue Zhang; Xingyuan He (Biodiversity and Conservation, 2021)

Three-dimensional forward modeling for the SBTEM method using an unstructured finite-element method - Wang Lu-Yuan; Yin Chang-Chun; Liu Yun-He; Su Yang; Ren Xiu-Yan; Hui Zhe-Jian; Zhang Bo; Xiong Bin (Applied Geophysics, 2021)

QTL mapping for foxtail millet plant height in multi-environment using an ultra-high density bin map - Qiang He; Hui Zhi; Sha Tang; Lu Xing; Suying Wang; Haigang Wang; Aiying Zhang; Yuhui Li; Ming Gao; Haijin Zhang; Guoqiu Chen; Shutao Dai; et al. (Theoretical and Applied Genetics, 2021)