Determining tolerance levels for quality assurance of 3D printed bolus for modulated arc radiotherapy of the nose - T. Kairn; S. Talkhani; P. H. Charles; B. Chua; C. Y. Lin; A. G. Livingstone; S. K. Maxwell; T. Poroa; E. Simpson-Page; E. Spelleken; M. Vo; S. B. Crowe (Physical and Engineering Sciences in Medicine, 2021)

Antigen production and development of an indirect ELISA based on the nucleocapsid protein to detect human SARS-CoV-2 seroconversion - Marcelo S. Conzentino; Karl Forchhammer; Emanuel M. Souza; Fábio O. Pedrosa; Meri B. Nogueira; Sônia M. Raboni; Fabiane G. M. Rego; Dalila L. Zanette; Mateus N. Aoki; Jeanine M. Nardin; Bruna Fornazari; Hugo M. P. Morales; et al. (Brazilian Journal of Microbiology, 2021)

Correction to: 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Bernard R. Agwanda; Rim Al Kubrusli; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Christopher F. Basler; et al. (Archives of Virology, 2021)

2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Bernard R. Agwanda; Rim Al Kubrusli; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Christopher F. Basler; et al. (Archives of Virology, 2021)

Investigation and disinfection of bacteria and fungi in sports fitness center - Nonglak Boonrattanakij; Sirikorn Yomchinda; Fang-Jia Lin; Luzvisminda M. Bellotindos; Ming-Chun Lu (Environmental Science and Pollution Research, 2021)

Global assessment of marine and freshwater recreational fish reveals mismatch in climate change vulnerability and conservation effort - Elizabeth A. Nyboer; Hsien‐Yung Lin; Joseph R. Bennett; Joseph Gabriel; William Twardek; Auston D. Chhor; Lindsay Daly; Sarah Dolson; Eric Guitard; Peter Holder; Christina M. Mozzon; Alexandria Trahan; et al. (Global Change Biology, 2021)
Recreational fisheries contribute substantially to the sociocultural and economic well‐being of coastal and riparian regions worldwide, but climate change threatens their sustainability. Fishery managers require information on how climate change will impact key recreational species; however, the absence of a global assessment hinders both directed and widespread conservation efforts. In this study, we present the first global climate change vulnerability assessment of recreationally targeted fish species from marine and freshwater environments (including diadromous fishes). We use climate change projections and data on species’ physiological and ecological traits to quantify and map global climate vulnerability and analyze these patterns alongside the indices of socioeconomic value and conservation effort to determine where efforts are sufficient and where they might fall short. We found that over 20% of recreationally targeted fishes are vulnerable to climate change under a high emission scenario. Overall, marine fishes had the highest number of vulnerable species, concentrated in regions with sensitive habitat types (e.g., coral reefs). However, freshwater fishes had higher proportions of species at risk from climate change, with concentrations in northern Europe, Australia, and southern Africa. Mismatches in conservation effort and vulnerability were found within all regions and life‐history groups. A key pattern was that current conservation effort focused primarily on marine fishes of high socioeconomic value rather than on the freshwater and diadromous fishes that were predicted to be proportionately more vulnerable. While several marine regions were notably lacking in protection (e.g., Caribbean Sea, Banda Sea), only 19% of vulnerable marine species were without conservation effort. By contrast, 72% of freshwater fishes and 33% of diadromous fishes had no measures in place, despite their high vulnerability and cultural value. The spatial and taxonomic analyses presented here provide guidance for the future conservation and management of recreational fisheries as climate change progresses.

Safety and tolerability of chronic intranasal oxytocin in older men: results from a randomized controlled trial - Jillian M. Rung; Marilyn Horta; Erin M. Tammi; Eliany Perez; Marite C. Ojeda; Tian Lin; Griffin Harris; Jessie Somerville; Dinia Salmeron; Susan E. Beltz; Bhanuprasad Sandesara; David Feifel; et al. (Psychopharmacology, 2021)

Correction to: Latest Miocene restriction of the Mediterranean Outflow Water: a perspective from the Gulf of Cádiz - Zhi Lin Ng; F. Javier Hernández-Molina; Débora Duarte; Francisco J. Sierro; Santiago Ledesma; Michael Rogerson; Estefanía Llave; Cristina Roque; M. Amine Manar (Geo-Marine Letters, 2021)

Legal Issues for Artificial Floating Islands - Maarten M. B. Flikkema; Fen-Yu (Vicky) Lin; Pernille P. J. van der Plank; Jos Koning; Olaf Waals (Frontiers in Marine Science, 2021)
Developments of multi-use floating islands are accelerated by an increase in offshore activities and pressing needs to create extra space in coastal regions for the surging population. The Horizon 2020 EU funded research project Space@Sea developed a modular floating island concept for offshore multi-use applications and examined current legal issues and barriers concerning its development. In this paper a floating island is defined to be “an artificially created floater, or set of connected floaters, moored to the seabed of which the topside can be used for activities similar to activities on land”. This paper aims to delve into governance issues like the assignment of authority on a multi-use floating island and the shift from regulating offshore living for working purposes to living purposes, as well as maritime law and property law (using the Netherlands as case study). Within the Exclusive Economic Zone (EEZ) a coastal state can establish, locate, and govern the floating island. For the high seas the International Maritime Organization (IMO) is the most probable organization to initiate a discussion on settlement of floating islands. For each activity on the floating island, limiting criteria regarding motions as well as safety rules and regulations need to be established. Industry and housing will have completely different requirements regarding safety which will not be possible to fit in a one size fits all regulation. This case study shows that current Dutch property law prohibit the division of ownership of buildings built on floating objects. They can only be owned together as one object. For urban expansion, future inhabitants will want to have the possibility to buy property, requiring an amendment of current property law. It is to be expected that other countries will have similar or additional governance challenges. The Space@Sea project has developed a technical solution for floating islands which have identified barriers for multi-use in the rules and regulations described in this paper. The paper urges the responsible institutions and stakeholders to take on their roles in overcoming these barriers.

Dynamics of Free-Living and Attached Bacterial Assemblages in Skeletonema sp. Diatom Cultures at Elevated Temperatures - Zichao Deng; Shouchang Chen; Ping Zhang; Xu Zhang; Jonathan M. Adams; Qiaoqi Luo; Xin Lin (Frontiers in Marine Science, 2021)
In the context of global warming, changes in phytoplankton-associated bacterial communities have the potential to change biogeochemical cycling and food webs in marine ecosystems. Skeletonema is a cosmopolitan diatom genus in coastal waters worldwide. Here, we grew a Skeletonema strain with its native bacterial assemblage at different temperatures and examined cell concentrations of Skeletonema sp. and free-living bacteria, dissolved organic carbon (DOC) concentrations of cultures, and the community structure of both free-living and attached bacteria at different culture stages. The results showed that elevated temperature increased the specific growth rates of both Skeletonema and free-living bacteria. Different growth stages had a more pronounced effect on community structure compared with temperatures and different physical states of bacteria. The effects of temperature on the structure of the free-living bacterial community were more pronounced compared with diatom-attached bacteria. Carbon metabolism genes and those for some specific amino acid pathways were found to be positively correlated with elevated temperature, which may have profound implications on the oceanic carbon cycle and the marine microbial loop. Network analysis revealed evidence of enhanced cooperation with an increase in positive interactions among different bacteria at elevated temperature. This may help the whole community to overcome the stress of elevated temperature. We speculate that different bacterial species may build more integrated networks with a modified functional profile of the whole community to cope with elevated temperature. This study contributes to an improved understanding of the response of diatom-associated bacterial communities to elevated temperature.

Latest Miocene restriction of the Mediterranean Outflow Water: a perspective from the Gulf of Cádiz - Zhi Lin Ng; F. Javier Hernández-Molina; Débora Duarte; Francisco J. Sierro; Santiago Ledesma; Michael Rogerson; Estefanía Llave; Cristina Roque; M. Amine Manar (Geo-Marine Letters, 2021)
The Mediterranean-Atlantic water mass exchange provides the ideal setting for deciphering the role of gateway evolution in ocean circulation. However, the dynamics of Mediterranean Outflow Water (MOW) during the closure of the Late Miocene Mediterranean-Atlantic gateways are poorly understood. Here, we define the sedimentary evolution of Neogene basins from the Gulf of Cádiz to the West Iberian margin to investigate MOW circulation during the latest Miocene. Seismic interpretation highlights a middle to upper Messinian seismic unit of transparent facies, whose base predates the onset of the Messinian salinity crisis (MSC). Its facies and distribution imply a predominantly hemipelagic environment along the Atlantic margins, suggesting an absence or intermittence of MOW preceding evaporite precipitation in the Mediterranean, simultaneous to progressive gateway restriction. The removal of MOW from the Mediterranean-Atlantic water mass exchange reorganized the Atlantic water masses and is correlated to a severe weakening of the Atlantic Meridional Overturning Circulation (AMOC) and a period of further cooling in the North Atlantic during the latest Miocene.

Low diversity of a key phytoplankton group along the West Antarctic Peninsula - Michael S. Brown; Jeff S. Bowman; Yajuan Lin; Colette J. Feehan; Carly M. Moreno; Nicolas Cassar; Adrian Marchetti; Oscar M. Schofield (Limnology and Oceanography, 2021)
The West Antarctic Peninsula (henceforth “Peninsula”) is experiencing rapid warming and melting that is impacting the regional marine food web. The primary phytoplankton groups along the Peninsula are diatoms and cryptophytes. Relative to diatoms, there has been little focus on regional cryptophytes, and thus our understanding of their diversity and ecology is limited, especially at the species level. This gap is important, as diatoms and cryptophytes play distinct roles in the regional marine food web and biogeochemistry. Here, we use a phylogenetic placement approach with 18S rRNA gene amplicon sequence variants to assess surface ocean cryptophyte diversity and its drivers at a high taxonomic resolution along the Peninsula. Data were collected over 5 years (2012–2016) during the regional research cruises of the Palmer Long‐Term Ecological Research program. Our results indicate that there are two major cryptophyte taxa along the Peninsula, consisting of distinct Geminigera spp., which in aggregate always comprise nearly 100% of the cryptophyte community (indicating low taxa evenness). The primary taxon dominates the cryptophyte community across all samples/years, which span a broad range of oceanographic conditions. A shift in cryptophyte community composition between a lower (higher) primary (secondary) taxon percentage is associated with distinct oceanographic conditions, including lower (higher) temperature, salinity, nutrients, and cryptophyte relative abundance (phytoplankton biomass and diatom relative abundance). These results emphasize the need for a full characterization of the ecology of these two taxa, as it is predicted that cryptophytes will increase along the Peninsula given projections of continued regional environmental change.

Identification of eight QTL controlling multiple yield components in a German multi-parental wheat population, including Rht24, WAPO-A1, WAPO-B1 and genetic loci on chromosomes 5A and 6A - Beatrice Corsi; Lia Obinu; Camila M. Zanella; Saverio Cutrupi; Rob Day; Manuel Geyer; Morten Lillemo; Min Lin; Lorenzo Mazza; Lawrence Percival-Alwyn; Melanie Stadlmeier; Volker Mohler; et al. (Theoretical and Applied Genetics, 2021)
Key message Quantitative trait locus (QTL) mapping of 15 yield component traits in a German multi-founder population identified eight QTL each controlling ≥2 phenotypes, including the genetic loci Rht24 , WAPO-A1 and WAPO-B1 . Abstract Grain yield in wheat ( Triticum aestivum L.) is a polygenic trait representing the culmination of many developmental processes and their interactions with the environment. Toward maintaining genetic gains in yield potential, ‘reductionist approaches’ are commonly undertaken by which the genetic control of yield components, that collectively determine yield, are established. Here we use an eight-founder German multi-parental wheat population to investigate the genetic control and phenotypic trade-offs between 15 yield components. Increased grains per ear was significantly positively correlated with the number of fertile spikelets per ear and negatively correlated with the number of infertile spikelets. However, as increased grain number and fertile spikelet number per ear were significantly negatively correlated with thousand grain weight, sink strength limitations were evident. Genetic mapping identified 34 replicated quantitative trait loci (QTL) at two or more test environments, of which 24 resolved into eight loci each controlling two or more traits—termed here ‘multi-trait QTL’ (MT-QTL). These included MT-QTL associated with previously cloned genes controlling semi-dwarf plant stature, and with the genetic locus Reduced height 24 ( Rht24 ) that further modulates plant height. Additionally, MT-QTL controlling spikelet number traits were located to chromosome 7A encompassing the gene WHEAT ORTHOLOG OF APO1 ( WAPO-A1 ), and to its homoeologous location on chromosome 7B containing WAPO-B1 . The genetic loci identified in this study, particularly those that potentially control multiple yield components, provide future opportunities for the targeted investigation of their underlying genes, gene networks and phenotypic trade-offs, in order to underpin further genetic gains in yield.

A novel pregnene analogs: synthesis, cytotoxicity on prostate cancer of PC-3 and LNCPa-AI cells and in silico molecular docking study - Nabeel A. Abdul-Rida; Ali M. Farhan; Najim A. Al-Masoudi; Bahjat A. Saeed; Dannah Miller; Ming-Fong Lin (Molecular Diversity, 2021)

Human endothelial colony-forming cells provide trophic support for pluripotent stem cell-derived cardiomyocytes via distinctively high expression of neuregulin-1 - Xuechong Hong; Nicholas Oh; Kai Wang; Joseph Neumeyer; Chin Nien Lee; Ruei-Zeng Lin; Breanna Piekarski; Sitaram Emani; Arin K. Greene; Ingeborg Friehs; Pedro J. del Nido; Juan M. Melero-Martin (Angiogenesis, 2021)

Recognize fish as food in policy discourse and development funding - Abigail Bennett; Xavier Basurto; John Virdin; Xinyan Lin; Samantha J. Betances; Martin D. Smith; Edward H. Allison; Barbara A. Best; Kelly D. Brownell; Lisa M. Campbell; Christopher D. Golden; Elizabeth Havice; et al. (Ambio, 2021)
The international development community is off-track from meeting targets for alleviating global malnutrition. Meanwhile, there is growing consensus across scientific disciplines that fish plays a crucial role in food and nutrition security. However, this ‘fish as food’ perspective has yet to translate into policy and development funding priorities. We argue that the traditional framing of fish as a natural resource emphasizes economic development and biodiversity conservation objectives, whereas situating fish within a food systems perspective can lead to innovative policies and investments that promote nutrition-sensitive and socially equitable capture fisheries and aquaculture. This paper highlights four pillars of research needs and policy directions toward this end. Ultimately, recognizing and working to enhance the role of fish in alleviating hunger and malnutrition can provide an additional long-term development incentive, beyond revenue generation and biodiversity conservation, for governments, international development organizations, and society more broadly to invest in the sustainability of capture fisheries and aquaculture.

Strengths and weaknesses in the long‐term sustainability of two sympatric seabreams ( Argyrops spinifer and Rhabdosargus haffara , S paridae) - Yu‐Jia Lin; Lotfi Rabaoui; Rommel H. Maneja; Abdu Rahiman Kambrath Pulikkoden; Panickan Premlal; Zahid Nazeer; Mohammad A. Qurban; Khaled Abdulkader; Perdana K. Prihartato; Ali M. Qasem; Nabil Fita; Ruben H. Roa‐Ureta (Journal of Fish Biology, 2021)
Argyrops spinifer and Rhabdosargus haffara are two sympatric seabream species making important contributions to fisheries landings in the western Arabian/Persian Gulf. We identified the strengths and weaknesses in the long‐term sustainability of A. spinifer and R. haffara stocks by integrating multiple sources of data, including fisheries catch and effort statistics, life history traits, scientific trawl surveys and historical length frequency distribution. Four strengths were identified in A. spinifer : wide distribution of juveniles, positive association to the network of de facto fishing exclusion areas created by hundreds of oil‐gas facilities, early maturation and the existence of large and old individuals. A. spinifer suffers from two potential weaknesses: slow growth rate and higher exploitation pressure on the small‐sized individuals. R. haffara , on the other hand, has a strength of having a short life span and a fast growth rate, characteristics that make it robust to unfavourable conditions. R. haffara suffers from two weaknesses: the lack of association to the oil and gas facilities, and the preference for nearshore shallow waters with stronger negative anthropogenic impacts. Identified strengths and weaknesses of these two sparids provided a preliminary assessment about their long‐term sustainability, as well as a roadmap about how to develop different management strategies to meet specific objectives.

From zero to infinity: Minimum to maximum diversity of the planet by spatio‐parametric Rao’s quadratic entropy - Duccio Rocchini; Matteo Marcantonio; Daniele Da Re; Giovanni Bacaro; Enrico Feoli; Giles M. Foody; Reinhard Furrer; Ryan J. Harrigan; David Kleijn; Martina Iannacito; Jonathan Lenoir; Meixi Lin; et al. (Global Ecology and Biogeography, 2021)
Aim The majority of work done to gather information on the Earth's biodiversity has been carried out using in‐situ data, with known issues related to epistemology (e.g., species determination and taxonomy), spatial uncertainty, logistics (time and costs), among others. An alternative way to gather information about spatial ecosystem variability is the use of satellite remote sensing. It works as a powerful tool for attaining rapid and standardized information. Several metrics used to calculate remotely sensed diversity of ecosystems are based on Shannon’s information theory, namely on the differences in relative abundance of pixel reflectances in a certain area. Additional metrics like the Rao’s quadratic entropy allow the use of spectral distance beside abundance, but they are point descriptors of diversity, that is they can account only for a part of the whole diversity continuum. The aim of this paper is thus to generalize the Rao’s quadratic entropy by proposing its parameterization for the first time. Innovation The parametric Rao’s quadratic entropy, coded in R, (a) allows the representation of the whole continuum of potential diversity indices in one formula, and (b) starting from the Rao’s quadratic entropy, allows the explicit use of distances among pixel reflectance values, together with relative abundances. Main conclusions The proposed unifying measure is an integration between abundance‐ and distance‐based algorithms to map the continuum of diversity given a satellite image at any spatial scale. Being part of the rasterdiv R package, the proposed method is expected to ensure high robustness and reproducibility.

Reap what you sow: local plant composition mediates bumblebee foraging patterns within urban garden landscapes - Megan O’Connell; Zachariah Jordan; Erin McGilvray; Hamutahl Cohen; Heidi Liere; Brenda B. Lin; Stacy M. Philpott; Shalene Jha (Urban Ecosystems, 2021)

The relationship between pollinator community and pollination services is mediated by floral abundance in urban landscapes - Hamutahl Cohen; Stacy M. Philpott; Heidi Liere; Brenda B. Lin; Shalene Jha (Urban Ecosystems, 2021)

AMPAr GluA1 Phosphorylation at Serine 845 in Limbic System Is Associated with Cardiac Autonomic Tone - Hiago Murilo Melo; Cristiane Ribeiro de Carvalho; Alexandre Ademar Hoeller; Jefferson Luiz Brum Marques; Marcelo Neves Linhares; Mark William Lopes; Guilherme Loureiro Fialho; Peter Wolf; Katia Lin; Zuner A. Bortolotto; Jeremy M. Henley; André D’Ávila; et al. (Molecular Neurobiology, 2021)

A global collaboration to study intimate partner violence-related head trauma: The ENIGMA consortium IPV working group - Carrie Esopenko; Jessica Meyer; Elisabeth A. Wilde; Amy D. Marshall; David F. Tate; Alexander P. Lin; Inga K. Koerte; Kimberly B. Werner; Emily L. Dennis; Ashley L. Ware; Nicola L. de Souza; Deleene S. Menefee; et al. (Brain Imaging and Behavior, 2021)

The clinical utility of proton magnetic resonance spectroscopy in traumatic brain injury: recommendations from the ENIGMA MRS working group - Brenda L Bartnik-Olson; Jeffry R Alger; Talin Babikian; Ashley D Harris; Barbara Holshouser; Ivan I Kirov; Andrew A Maudsley; Paul M Thompson; Emily L Dennis; David F Tate; Elisabeth A Wilde; Alexander Lin (Brain Imaging and Behavior, 2021)

The ENIGMA sports injury working group:– an international collaboration to further our understanding of sport-related brain injury - Inga K. Koerte; Carrie Esopenko; Sidney R. Hinds; Martha E. Shenton; Elena M. Bonke; Jeffrey J. Bazarian; Kevin C. Bickart; Erin D. Bigler; Sylvain Bouix; Thomas A. Buckley; Meeryo C. Choe; Paul S. Echlin; et al. (Brain Imaging and Behavior, 2021)
Sport-related brain injury is very common, and the potential long-term effects include a wide range of neurological and psychiatric symptoms, and potentially neurodegeneration. Around the globe, researchers are conducting neuroimaging studies on primarily homogenous samples of athletes. However, neuroimaging studies are expensive and time consuming, and thus current findings from studies of sport-related brain injury are often limited by small sample sizes. Further, current studies apply a variety of neuroimaging techniques and analysis tools which limit comparability among studies. The ENIGMA Sports Injury working group aims to provide a platform for data sharing and collaborative data analysis thereby leveraging existing data and expertise. By harmonizing data from a large number of studies from around the globe, we will work towards reproducibility of previously published findings and towards addressing important research questions with regard to diagnosis, prognosis, and efficacy of treatment for sport-related brain injury. Moreover, the ENIGMA Sports Injury working group is committed to providing recommendations for future prospective data acquisition to enhance data quality and scientific rigor.

The influence of vector‐borne disease on human history: socio‐ecological mechanisms - Tejas S. Athni; Marta S. Shocket; Lisa I. Couper; Nicole Nova; Iain R. Caldwell; Jamie M. Caldwell; Jasmine N. Childress; Marissa L. Childs; Giulio A. De Leo; Devin G. Kirk; Andrew J. MacDonald; Kathryn Olivarius; et al. (Ecology Letters, 2021)
Vector‐borne diseases (VBDs) are embedded within complex socio‐ecological systems. While research has traditionally focused on the direct effects of VBDs on human morbidity and mortality, it is increasingly clear that their impacts are much more pervasive. VBDs are dynamically linked to feedbacks between environmental conditions, vector ecology, disease burden, and societal responses that drive transmission. As a result, VBDs have had profound influence on human history. Mechanisms include: (1) killing or debilitating large numbers of people, with demographic and population‐level impacts; (2) differentially affecting populations based on prior history of disease exposure, immunity, and resistance; (3) being weaponised to promote or justify hierarchies of power, colonialism, racism, classism and sexism; (4) catalysing changes in ideas, institutions, infrastructure, technologies and social practices in efforts to control disease outbreaks; and (5) changing human relationships with the land and environment. We use historical and archaeological evidence interpreted through an ecological lens to illustrate how VBDs have shaped society and culture, focusing on case studies from four pertinent VBDs: plague, malaria, yellow fever and trypanosomiasis. By comparing across diseases, time periods and geographies, we highlight the enormous scope and variety of mechanisms by which VBDs have influenced human history.

Storm Gloria: Sea State Evolution Based on in situ Measurements and Modeled Data and Its Impact on Extreme Values - Marta de Alfonso; Jue Lin-Ye; José M. García-Valdecasas; Susana Pérez-Rubio; M. Yolanda Luna; Daniel Santos-Muñoz; M. Isabel Ruiz; Begoña Pérez-Gómez; Enrique Álvarez-Fanjul (Frontiers in Marine Science, 2021)
Storm Gloria, generated on January 17th, 2020 in the Eastern North Atlantic, crossed the Iberian Peninsula and impacted the Western Mediterranean during the following days. The event produced relevant damages on the coast and the infrastructures at the Catalan-Balearic Sea, due to extraordinary wind and wave fields, concomitant with anomalously intense rain and ocean currents. Puertos del Estado (the Spanish holding of harbors) has developed and operates a complex monitoring and forecasting system (PORTUS System), in collaboration with the Spanish Met Office (AEMET). The present work shows how Gloria was correctly forecasted by this system, alerts were properly issued (with special focus to the ports), and the buoys were able to monitor the sea state conditions during the event, measuring several new records of significant wave height and exceptional high mean wave periods. The paper describes, in detail, the dynamic evolution of the atmospheric conditions, and the sea state during the storm. It is by means of the study of both in situ and modeled PORTUS data, in combination with the AEMET weather forecast system results. The analysis also serves to place this storm in a historical context, showing the exceptional nature of the event, and to identify the specific reasons why its impact was particularly severe. The work also demonstrates the relevance of the PORTUS System to warn, in advance, the main Spanish Ports. It prevents accidents that could result in fatal casualties. To do so, the wave forecast warning performance is analyzed, making special focus on the skill score for the different horizons. Furthermore, it is demonstrated how a storm of this nature results in the need of changes on the extreme wave analysis for the area. It impacts all sorts of design activities at the coastline. The paper studies both how this storm fits into existing extreme analysis and how these should be modified in the light of this particular single event. This work is the first of a series of papers to be published on this issue. They analyze, in detail, other aspects of the event, including evolution of sea level and description of coastal damages.

Characterization and validation of QTLs for adult plant stripe rust resistance in Chinese wheat landrace Dabaimai - M. Y. Wang; M. R. Xu; F. T. Wang; S. J. A. Shah; J. Feng; R. M. Lin; S. C. Xu (Cereal Research Communications, 2021)

Genetic diversity and life‐history traits of bonefish Albula spp. from the Red Sea - Collin T. Williams; Ashlie J. McIvor; Elizabeth M. Wallace; Yu‐Jia Lin; Michael L. Berumen (Journal of Fish Biology, 2021)
The management of bonefishes Albula spp. has been hindered by unresolved species distributions and a general lack of life‐history information. This study provides the first genetic species identifications of Albula spp. from the northern Indian Ocean. The roundjaw bonefish Albula glossodonta was documented in the Red Sea, and the smallscale bonefish A. oligolepis was identified in the Gulf of Aden with no evidence supporting sympatry. Estimates of genetic differentiation indicate three closely related lineages of A. glossodonta in the Red Sea, Indian Ocean and Pacific Ocean (Red Sea‐Pacific Ocean, F st = 0.295; Red Sea‐Seychelles, F st = 0.193; Pacific Ocean‐Seychelles, F st = 0.141). In addition, the authors provide the first life‐history information of Albula spp. in the Indian Ocean. Age‐based growth models of A. glossodonta from the Red Sea demonstrated statistically significant differences compared to previously published data from the Pacific Ocean. Spawning activity during winter months was derived from gonado‐somatic index values of A. glossodonta from the Red Sea and corresponded with spawning seasonality previously documented for the species in the Pacific Ocean. The results of this study aid in refining biogeographical uncertainties of Albula spp. and illustrate the importance of collecting regional growth information for subsequent management of A. glossodonta .

Warming Iron-Limited Oceans Enhance Nitrogen Fixation and Drive Biogeographic Specialization of the Globally Important Cyanobacterium Crocosphaera - Nina Yang; Carlin A. Merkel; Yu-An Lin; Naomi M. Levine; Nicholas J. Hawco; Hai-Bo Jiang; Ping-Ping Qu; Michelle A. DeMers; Eric A. Webb; Fei-Xue Fu; David A. Hutchins (Frontiers in Marine Science, 2021)
Primary productivity in the nutrient-poor subtropical ocean gyres depends on new nitrogen inputs from nitrogen fixers that convert inert dinitrogen gas into bioavailable forms. Temperature and iron (Fe) availability constrain marine nitrogen fixation, and both are changing due to anthropogenic ocean warming. We examined the physiological responses of the globally important marine nitrogen fixer, Crocosphaera watsonii across its full thermal range as a function of iron availability. At the lower end of its thermal range, from 22 to 27°C, Crocosphaera growth, nitrogen fixation, and Nitrogen-specific Iron Use Efficiencies (N-IUEs, mol N fixed hour –1 mol Fe –1 ) increased with temperature. At an optimal growth temperature of 27°C, N-IUEs were 66% higher under iron-limited conditions than iron-replete conditions, indicating that low-iron availability increases metabolic efficiency. However, Crocosphaera growth and function decrease from 27 to 32°C, temperatures that are predicted for an increasing fraction of tropical oceans in the future. Altogether, this suggests that Crocosphaera are well adapted to iron-limited, warm waters, within prescribed limits. A model incorporating these results under the IPCC RCP 8.5 warming scenario predicts that Crocosphaera N-IUEs could increase by a net 47% by 2100, particularly in higher-latitude waters. These results contrast with published responses of another dominant nitrogen fixer ( Trichodesmium ), with predicted N-IUEs that increase most in low-latitude, tropical waters. These models project that differing responses of Crocosphaera and Trichodesmium N-IUEs to future warming of iron-limited oceans could enhance their current contributions to global marine nitrogen fixation with rates increasing by ∼91 and ∼22%, respectively, thereby shifting their relative importance to marine new production and also intensifying their regional divergence. Thus, interactive temperature and iron effects may profoundly transform existing paradigms of nitrogen biogeochemistry and primary productivity in open ocean regimes.

Evaluation of favourable hot dry rock areas in the east of the Yishu fault zone in China - Q. Deng; A. Jiang; Z. Tong; H. Lin; Z. Gao; X. Sun; M. Nie (Australian Journal of Earth Sciences, 2021)

Machine learning prediction of neurocognitive impairment among people with HIV using clinical and multimodal magnetic resonance imaging data - Yunan Xu; Yizi Lin; Ryan P. Bell; Sheri L. Towe; John M. Pearson; Tauseef Nadeem; Cliburn Chan; Christina S. Meade (Journal of NeuroVirology, 2021)

Application of plant metabarcoding to identify diverse honeybee pollen forage along an urban–agricultural gradient - Rodney T. Richardson; Tyler D. Eaton; Chia‐Hua Lin; Garrett Cherry; Reed M. Johnson; Douglas B. Sponsler (Molecular Ecology, 2021)
Understanding animal foraging ecology requires large sample sizes spanning broad environmental and temporal gradients. For pollinators, this has been hampered by the laborious nature of morphologically identifying pollen. Identifying pollen from urban environments is particularly difficult due to the presence of diverse ornamental species associated with consumer horticulture. Metagenetic pollen analysis represents a potential solution to this issue. Building upon prior laboratory and bioinformatic methods, we applied quantitative multilocus metabarcoding to characterize the foraging ecology of honeybee colonies situated in urban, suburban, mixed suburban–agricultural and rural agricultural sites in central Ohio, USA. In cross‐validating a subset of our metabarcoding results using microscopic palynology, we find strong concordance between the molecular and microscopic methods. Our results suggest that forage from the agricultural site exhibited decreased taxonomic diversity and temporal turnover relative to the urban and suburban sites, though the generalization of this observation will require replication across additional sites and cities. Our work demonstrates the power of honeybees as environmental samplers of floral community composition at large spatial scales, aiding in the distinction of taxa characteristically associated with urban or agricultural land use from those distributed ubiquitously across the sampled landscapes. Observed patterns of high forage diversity and compositional turnover in our more urban sites are likely reflective of the fine‐grain heterogeneity and high beta diversity of urban floral landscapes at the scale of honeybee foraging. This provides guidance for future studies investigating how relationships between urbanization and measures of pollinator health are mediated by variation in floral resource dynamics across landscapes.

Stocks and losses of soil organic carbon from Chinese vegetated coastal habitats - Chuancheng Fu; Yuan Li; Lin Zeng; Haibo Zhang; Chen Tu; Qian Zhou; Kuanxu Xiong; Jiaping Wu; Carlos M. Duarte; Peter Christie; Yongming Luo (Global Change Biology, 2021)
Global vegetated coastal habitats (VCHs) represent a large sink for organic carbon (OC) stored within their soils. The regional patterns and causes of spatial variation, however, remain uncertain. The sparsity and regional bias of studies on soil OC stocks from Chinese VCHs have limited the reliable estimation of their capacity as regional and global OC sinks. Here, we use field and published data from 262 sampled soil cores and 181 surface soils to report estimates of soil OC stocks, burial rates and losses of VCHs in China. We find that Chinese mangrove, salt marsh and seagrass habitats have relatively low OC stocks, storing 6.3 ± 0.6, 7.5 ± 0.6, and 1.6 ± 0.6 Tg C (±95% confidence interval) in the top meter of the soil profile with burial rates of 44 ± 17, 159 ± 57, and 6 ± 45 Gg C/year, respectively. The variability in the soil OC stocks is linked to biogeographic factors but is mostly impacted by sedimentary processes and anthropic activities. All habitats have experienced significant losses, resulting in estimated emissions of 94.2–395.4 Tg CO 2 e (carbon dioxide equivalent) over the past 70 years. Reversing this trend through conservation and restoration measures has, therefore, great potential in contributing to the mitigation of climate change while providing additional benefits. This assessment, on a national scale from highly sedimentary environments under intensive anthropogenic pressures, provides important insights into blue carbon sink mechanism and sequestration capacities, thus contributing to the synchronous progression of global blue carbon management.

A review of the Chinese monotypic genus Melliodendron (Styracaceae), with a new synonym of M. xylocarpum - Xue-Hui Wu; Rui Zhang; Timothy M. A. Utteridge; Yu-Lin Liu; Guang-Yao Yang; Ming Tang (Kew Bulletin, 2020)

Melatonin ameliorates spatial memory and motor deficits via preserving the integrity of cortical and hippocampal dendritic spine morphology in mice with neurotrauma - Xiao-Jing Lin; Ruoxu Liu; Chenyi Li; Xueqing Yi; Bo Fu; M. J. Walker; Xiao-Ming Xu; Gang Sun; Cheng-Hsien Lin (Inflammopharmacology, 2020)

Large-scale control on the frequency of tropical cyclones and seeds: a consistent relationship across a hierarchy of global atmospheric models - Tsung-Lin Hsieh; Gabriel A. Vecchi; Wenchang Yang; Isaac M. Held; Stephen T. Garner (Climate Dynamics, 2020)
A diagnostic framework is developed to explain the response of tropical cyclones (TCs) to climate in high-resolution global atmospheric models having different complexity of boundary conditions. The framework uses vortex dynamics to identify the large-scale control on the evolution of TC precursors—first non-rotating convective clusters and then weakly rotating seeds. In experiments with perturbed sea surface temperature (SST) and $$\hbox {CO}_2$$ CO 2 concentration from the historical values, the response of TCs follows the response of seeds. The distribution of seeds is explained by the distribution of the non-rotating convective clusters multiplied by a probability that they transition to seeds. The distribution of convective clusters is constrained by the large-scale vertical velocity and is verified in aquaplanet experiments with shifting Inter tropical Convergence Zones. The probability of transition to seeds is constrained by the large-scale vorticity via an analytical function, representing the relative importance between vortex stretching and vorticity advection, and is verified in aquaplanet experiments with uniform SST. The consistency between seed and TC responses breaks down substantially when the realistic SST is perturbed such that the spatial gradient is significantly enhanced or reduced. In such cases, the difference between the responses is explained by a change in the ventilation index, which influences the fraction of seeds that develop into TCs. The proposed TC-climate relationship serves as a framework to explain the diversity of TC projection across models and forcing scenarios.

Transcellular Model for Neutral and Charged Nanoparticles Across an In Vitro Blood–Brain Barrier - Lin Zhang; Jie Fan; Guanglei Li; Zhaokai Yin; Bingmei M. Fu (Cardiovascular Engineering and Technology, 2020)

Brain structural connectomes indicate shared neural circuitry involved in subjective experience of cognitive and physical fatigue in older adults - Timothy M. Baran; Zhengwu Zhang; Andrew James Anderson; Kelsey McDermott; Feng Lin (Brain Imaging and Behavior, 2020)

2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Daniela Alioto; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Simon J. Anthony; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Tomáš Bartonička; et al. (Archives of Virology, 2020)

Regional drivers of diversification in the late Quaternary in a widely distributed generalist species, the common pheasant Phasianus colchicus - Simin Liu; Yang Liu; Edouard Jelen; Mansour Alibadian; Cheng‐Te Yao; Xintong Li; Nasrin Kayvanfar; Yutao Wang; Farhad S. M. Vahidi; Jian‐Lin Han; Gombobaatar Sundev; Zhengwang Zhang; et al. (Journal of Biogeography, 2020)
Aim Pleistocene climate and associated environmental changes have influenced phylogeographic patterns of many species. These not only depend on a species’ life history but also vary regionally. Consequently, populations of widespread species that occur in several biomes might display different evolutionary trajectories. We aimed to identify regional drivers of diversification in the common pheasant, a widely distributed ecological generalist. Location Asia. Taxon Common pheasant Phasianus colchicus . Methods Using a comprehensive geographical sampling of 204 individuals from the species’ entire range genotyped at seven nuclear and two mitochondrial loci, we reconstructed spatio‐temporal diversification and demographic history of the common pheasant. We applied Bayesian phylogenetic inference to describe phylogeographic structure, generated a species tree and inferred demographic history within and migration between lineages. Moreover, to establish a taxonomic framework, we conducted a species delimitation analysis. Results The common pheasant diversified during the Late Pleistocene into eight distinct lineages. It originated at the edge of the Qinghai–Tibetan plateau and spread to East and Central Asia. Only the widely distributed lowland lineage of East Asia displayed recent range expansion. Greater phylogeographic structure was identified elsewhere, with lineages showing no sign of recent demographic changes. One lineage in south‐central China is the result of long‐term isolation within a climatically stable but topographically complex region. In lineages from arid Central Asia and China, range expansions were impeded by repeated population fragmentation during dry glacial periods and by recent aridification. Main conclusions Spatio‐temporal phylogeographic frameworks of widespread taxa such as the common pheasant provide valuable opportunities to identify divergent drivers of regional diversification. Our results suggest that diversification and population histories in the eight distinct evolutionary lineages were shaped by regionally variable effects of past climate and associated environmental changes. The evolutionary history of the common pheasant is best reflected by its being split into three species.

Public Perceptions of Mangrove Forests Matter for Their Conservation - Farid Dahdouh-Guebas; Gordon N. Ajonina; A. Aldrie Amir; Dominic A. Andradi-Brown; Irfan Aziz; Thorsten Balke; Edward B. Barbier; Stefano Cannicci; Simon M. Cragg; Marília Cunha-Lignon; David J. Curnick; Carlos M. Duarte; et al. (Frontiers in Marine Science, 2020)

Advanced psychometric testing on a clinical screening tool to evaluate insomnia: sleep condition indicator in patients with advanced cancer - Chung-Ying Lin; Andy S. K. Cheng; Vida Imani; Mohsen Saffari; Maurice M. Ohayon; Amir H. Pakpour (Sleep and Biological Rhythms, 2020)
Purpose To examine the psychometric properties of the Sleep Condition Indicator (SCI) using different psychometric approaches [including classical test theory, Rasch models, and receiver operating characteristics (ROC) curve] among patients with advanced cancer. Methods Through convenience sampling, patients with cancer at stage III or IV ( n = 859; 511 males; mean ± SD age = 67.4 ± 7.5 years) were recruited from several oncology units of university hospitals in Iran. All the participants completed the SCI, Insomnia Severity Index (ISI), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Hospital Anxiety and Depression Scale (HADS), General Health Questionnaire (GHQ), and Edmonton Symptom Assessment Scale (ESAS). In addition, 491 participants wore an actigraph device to capture objective sleep. Results Classical test theory [factor loadings from confirmatory factor analysis = 0.76–0.89; test–retest reliability = 0.80–0.93] and Rasch analysis [infit mean square (MnSq) = 0.63–1.31; outfit MnSq = 0.61–1.23] both support the construct validity of the SCI. The SCI had significant associations with ISI, PSQI, ESS, HADS, GHQ, and ESAS. In addition, the SCI has satisfactory area under ROC curve (0.92) when comparing a gold standard of insomnia diagnosis. Significant differences in the actigraphy measure were found between insomniacs and non-insomniacs based on the SCI score defined by ROC. Conclusion With the promising psychometric properties shown in the SCI, healthcare providers can use this simple assessment tool to target the patients with advanced cancer who are at risk of insomnia and subsequently provide personalized care efficiently.

Peripheral ProBDNF Delivered by an AAV Vector to the Muscle Triggers Depression-Like Behaviours in Mice - L. Y. Lin; S. Kelliny; L. C. Liu; M. Al-Hawwas; X. F. Zhou; L. Bobrovskaya (Neurotoxicity Research, 2020)

Active ingredients of Inula helenium L. exhibits similar anti-cancer effects as isoalantolactone in pancreatic cancer cells - Y. Y. Yan; Q. Zhang; B. Zhang; B. Yang; N. M. Lin (Natural Product Research, 2020)

Stem-Cell Therapy as a Potential Strategy for Radiation-Induced Brain Injury - Chengyan Chu; Yue Gao; Xiaoyan Lan; Jianwen Lin; Aline M. Thomas; Shen Li (Stem Cell Reviews and Reports, 2020)

Metabolomics profiling of visceral and abdominal subcutaneous adipose tissue in colorectal cancer patients: results from the ColoCare study - Jennifer Ose; Andreana N. Holowatyj; Johanna Nattenmüller; Biljana Gigic; Tengda Lin; Caroline Himbert; Nina Habermann; David Achaintre; Augustin Scalbert; Pekka Keski-Rahkonen; Jürgen Böhm; Petra Schrotz-King; et al. (Cancer Causes & Control, 2020)

A System Level Analysis of Coastal Ecosystem Responses to Hurricane Impacts - C. J. Patrick; L. Yeager; A. R. Armitage; F. Carvallo; V. M. Congdon; K. H. Dunton; M. Fisher; A. K. Hardison; J. D. Hogan; J. Hosen; X. Hu; B. Kiel Reese; et al. (Estuaries and Coasts, 2020)

A Major Hydrothermal Reservoir Underneath the Tatun Volcano Group of Taiwan: Clues from a Dense Linear Geophone Array - C. H. Lin; Y. C. Lai; M. H. Shih; C. J. Lin; J. S. Ku; Y. C. Huang (Pure and Applied Geophysics, 2020)
A dense linear geophone array is deployed across the Tatun volcano group (TVG) at the northern tip of Taiwan, where more than 7 million residents live in the Taipei metropolis. The array is composed of 50 geophones with a station spacing of ~ 200 m in average, and it is designed for striking in the NW–SE direction to record the many earthquakes in eastern Taiwan, where the Philippine Sea plate subducted beneath the Eurasia plate. The detailed examination of felt earthquakes shows consistent P-wave delays are recorded at particular stations of the array. The further forward modeling indicates there is a low-velocity zone (LVZ) at depths between ~ 0.5 and ~ 2.5 km beneath the major fumarole sites. Combining this preliminary result with previous studies including clustering seismicity, volcanic earthquakes, low-resistivity zone, strong degassing processes and shallow velocity structures, we suggest that the LVZ might be associated with the major hydrothermal reservoir at the TVG. The identification of the hydrothermal reservoir by the LVZ not only implies a potential volcanic threat, such as phreatic eruptions, in the future, but also provides the possibility of sustainable geothermal resources for replacing traditional nuclear and fossil fuel power plants. Detailed images of the LVZ and other volcanic structures will be obtained soon when dense geophone arrays with more than 600 geophones are deployed from 2020 to 2022.

DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver - Mohamad M. Kronfol; Fay M. Jahr; Mikhail G. Dozmorov; Palak S. Phansalkar; Lin Y. Xie; Karolina A. Aberg; MaryPeace McRae; Elvin T. Price; Patricia W. Slattum; Philip M. Gerk; Joseph L. McClay (GeroScience, 2020)

Non-Invasive Quantification of Ventricular Contractility, Arterial Elastic Function and Ventriculo-Arterial Coupling from a Single Diagnostic Encounter Using Simultaneous Arterial Tonometry and Magnetic Resonance Imaging - Mayooran Namasivayam; Audrey Adji; Linda Lin; Christopher S. Hayward; Michael P. Feneley; Michael F. O’Rourke; David W. M. Muller; Andrew Jabbour (Cardiovascular Engineering and Technology, 2020)

Fetal Transcatheter Trileaflet Heart Valve Hemodynamics: Implications of Scaling on Valve Mechanics and Turbulence - Hoda Hatoum; Shelley Gooden; Megan Heitkemper; Kevin M. Blum; Jason Zakko; Martin Bocks; Tai Yi; Yen-Lin Wu; Yadong Wang; Christopher K. Breuer; Lakshmi Prasad Dasi (Annals of Biomedical Engineering, 2020)

Sedimentary environment and facies of the Huagang Formation in the northern central Xihu Depression, East China Sea Basin, China - Z. X. Zhao; C. M. Dong; C. Y. Lin; X. G. Zhang; X. Huang; B. J. Li; W. Guo; Z. Q. Zhu (Australian Journal of Earth Sciences, 2020)

A deep-level region-based visual representation architecture for detecting strawberry flowers in an outdoor field - P. Lin; W. S. Lee; Y. M. Chen; N. Peres; C. Fraisse (Precision Agriculture, 2020)

Marine latitudinal diversity gradients, niche conservatism and out of the tropics and Arctic: Climatic sensitivity of small organisms - Wing‐Tung Ruby Chiu; Moriaki Yasuhara; Thomas M. Cronin; Gene Hunt; Laura Gemery; Chih‐Lin Wei (Journal of Biogeography, 2020)
Aim The latitudinal diversity gradient (LDG) is a consequence of evolutionary and ecological mechanisms acting over long history, and thus is best investigated with organisms that have rich fossil records. However, combined neontological‐palaeontological investigations are mostly limited to large, shelled invertebrates, which keeps our mechanistic understanding of LDGs in its infancy. This paper aims to describe the modern meiobenthic ostracod LDG and to explore the possible controlling factors and the evolutionary mechanisms of this large‐scale biodiversity pattern. Location Present‐day Western North Atlantic. Taxon Ostracoda. Methods We compiled ostracod census data from shallow‐marine environments of the western North Atlantic Ocean. Using these data, we documented the marine LDG with multiple metrics of alpha, beta (nestedness and turnover) and gamma diversity, and we tested whether macroecological patterns could be governed by different environmental factors, including temperature, salinity, dissolved oxygen, pH and primary productivity. We also explored the geologic age distribution of ostracod genera to investigate the evolutionary mechanisms underpinning the LDG. Results Our results show that temperature and climatic niche conservatism are important in setting LDGs of these small, poorly dispersing organisms. We also found evidence for some dispersal‐driven spatial dynamics in the ostracod LDG. Compared to patterns observed in marine bivalves, however, dispersal dynamics were weaker and they were bi‐directional, rather than following the ‘out‐of‐the‐tropics’ model. Main conclusions Our detailed analyses revealed that meiobenthic organisms, which comprise two‐thirds of marine diversity, do not always follow the same rules as larger, better‐studied organisms. Our findings suggest that the understudied majority of biodiversity may be more sensitive to climate than well‐studied, large organisms. This implies that the impacts of ongoing Anthropocene climatic change on marine ecosystems may be much more serious than presently thought.

Correction to: Microsatellite records for volume 10, issue 2 - Dan Yu; Xueyun Ding; Zhi Zhang; Yu Zeng; Huanzhang Liu; Lin Wang; Ye Gong; Xingtu Liu; Xianguo Lyu; Gregory R. McCracken; Francisca V. Valenzuela-Aguayo; Evelyn M. Habit; et al. (Conservation Genetics Resources, 2020)

Potential changes to the biology and challenges to the management of invasive sea lamprey Petromyzon marinus in the Laurentian Great Lakes due to climate change - Robert J. Lennox; Gale A. Bravener; Hsien‐Yung Lin; Charles P. Madenjian; Andrew M. Muir; Christina K. Remucal; Kelly F. Robinson; Andrew M. Rous; Michael J. Siefkes; Michael P. Wilkie; Daniel P. Zielinski; Steven J. Cooke (Global Change Biology, 2020)
Control programs are implemented to mitigate the damage caused by invasive species worldwide. In the highly invaded Great Lakes, the climate is expected to become warmer with more extreme weather and variable precipitation, resulting in shorter iced‐over periods and variable tributary flows as well as changes to pH and river hydrology and hydrogeomorphology. We review how climate change influences physiology, behavior, and demography of a damaging invasive species, sea lamprey ( Petromyzon marinus ), in the Great Lakes, and the consequences for sea lamprey control efforts. Sea lamprey control relies on surveys to monitor abundance of larval sea lamprey in Great Lakes tributaries. The abundance of parasitic, juvenile sea lampreys in the lakes is calculated by surveying wounding rates on lake trout ( Salvelinus namaycush ), and trap surveys are used to enumerate adult spawning runs. Chemical control using lampricides (i.e., lamprey pesticides) to target larval sea lamprey and barriers to prevent adult lamprey from reaching spawning grounds are the most important tools used for sea lamprey population control. We describe how climate change could affect larval survival in rivers, growth and maturation in lakes, phenology and the spawning migration as adults return to rivers, and the overall abundance and distribution of sea lamprey in the Great Lakes. Our review suggests that Great Lakes sea lamprey may benefit from climate change with longer growing seasons, more rapid growth, and greater access to spawning habitat, but uncertainties remain about the future availability and suitability of larval habitats. Consideration of the biology of invasive species and adaptation of the timing, intensity, and frequency of control efforts is critical to the management of biological invasions in a changing world, such as sea lamprey in the Great Lakes.

Remobilization of metasomatized mantle lithosphere: a new model for the Jiaodong gold province, eastern China - Jun Deng; Qingfei Wang; M Santosh; Xuefei Liu; Yayun Liang; Liqiang Yang; Rui Zhao; Lin Yang (Mineralium Deposita, 2020)

Managing water quality in a river basin with uncertainty - H.-W. Chen; W.-Y. Chen; C.-T. Wang; Y.-H. Lin; M.-J. Deng; C.-Y. Chiang (International Journal of Environmental Science and Technology, 2020)

Changes in abundance and composition of nitrifying communities in barley (Hordeum vulgare L.) rhizosphere and bulk soils over the growth period following combined biochar and urea amendment - Lu Yu; Peter M. Homyak; Xiaoxi Kang; Philip C. Brookes; Yikai Ye; Yeneng Lin; Afzal Muhammad; Jianming Xu (Biology and Fertility of Soils, 2020)

Synthetic cathelicidin LL-37 reduces Mycobacterium avium subsp. paratuberculosis internalization and pro-inflammatory cytokines in macrophages - Karina M. Cirone; Priyoshi Lahiri; Ravi Holani; Yi Lin Tan; Rakel Arrazuria; Jeroen De Buck; Herman W. Barkema; Eduardo R. Cobo (Cell and Tissue Research, 2020)

TRY plant trait database – enhanced coverage and open access - Jens Kattge; Gerhard Bönisch; Sandra Díaz; Sandra Lavorel; Iain Colin Prentice; Paul Leadley; Susanne Tautenhahn; Gijsbert D. A. Werner; Tuomas Aakala; Mehdi Abedi; Alicia T. R. Acosta; George C. Adamidis; et al. (Global Change Biology, 2020)
Plant traits—the morphological, anatomical, physiological, biochemical and phenological characteristics of plants—determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait‐based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits—almost complete coverage for ‘plant growth form’. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait–environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives.

Study on arbor leaf and ring as a potential biological indicator for atmospheric polybrominated diphenyl ethers (PBDEs) distribution at e-wastes recycling sites - M. Gao; G. Wang; B. Lin; M. Tariq; K. Liu; W. Zhang (International Journal of Environmental Science and Technology, 2019)

Trace and rare earth element geochemistry of Holocene hydromagnesite from Dujiali Lake, central Qinghai–Tibetan Plateau, China - Yongjie Lin; Mianping Zheng; Chuanyong Ye; Ian M. Power (Carbonates and Evaporites, 2019)

Transgenic maize phosphoenolpyruvate carboxylase alters leaf–atmosphere CO2 and 13CO2 exchanges in Oryza sativa - Rita Giuliani; Shanta Karki; Sarah Covshoff; Hsiang-Chun Lin; Robert A. Coe; Nuria K. Koteyeva; Marc A. Evans; W. Paul Quick; Susanne von Caemmerer; Robert T. Furbank; Julian M. Hibberd; Gerald E. Edwards; et al. (Photosynthesis Research, 2019)

Tropical cyclone sensitivities to CO2 doubling: roles of atmospheric resolution, synoptic variability and background climate changes - Gabriel A. Vecchi; Thomas L. Delworth; Hiroyuki Murakami; Seth D. Underwood; Andrew T. Wittenberg; Fanrong Zeng; Wei Zhang; Jane W. Baldwin; Kieran T. Bhatia; William Cooke; Jie He; Sarah B. Kapnick; et al. (Climate Dynamics, 2019)

Effect of Peptide AEDG on Telomere Length and Mitotic Index of PHA-Stimulated Human Blood Lymphocytes - V. Kh. Khavinson; A. A. Pendina; O. A. Efimova; A. V. Tikhonov; A. S. Koltsova; M. I. Krapivin; A. V. Petrovskaia-Kaminskaia; L. I. Petrova; N. S. Lin’kova; V. S. Baranov (Bulletin of Experimental Biology and Medicine, 2019)

Permian felsic magmatism in the Neoproterozoic Nagar Parkar Igneous Complex of the Malani Igneous Suite: Evidence from zircon U–Pb age - Hafiz U. Rehman; Tahseenullah Khan; Hao‐Yang Lee; Sun‐Lin Chung; Mamoru Murata; M. Qasim Jan (Island Arc, 2019)
We report Permian ( ca . 272 Ma ±5.4 Ma) felsic dykes that intrude into the Neoproterozoic ( ca . 750 Ma) magmatic suite of the Nagar Parkar Igneous Complex (NPIC), the western extension of the Malani Igneous Suite (MIS). The NPIC consists of Neoproterozoic basement amphibolites and granites (riebeckite–aegirine gray granites and the biotite–hornblende pink granites), all of which are intruded by several generations of mafic and felsic dykes. Granitic magmatism occurred in the Late Neoproterozoic ( ca . 750 Ma) due to the subduction‐, followed by the rift‐related tectonic regime during the breakup of the Rodinia supercontinent. U–Th–Pb zircon and monazite CHIME age data of 700–800 Ma from the earlier generation porphyritic felsic dykes suggest the dyke intrusion was coeval or soon after the emplacement of the host granites. Our findings of Permian age orthophyric felsic dykes provide new insights for the prevalence of active tectonics in the MIS during late Paleozoic. Textural features and geochemistry also make the orthophyric dykes distinct from the early‐formed porphyritic dykes and the host granites. Our newly obtained age data combined with geochemistry, suggest the existence of magmatism along the western margin of India (peri‐Gondwana margin) during Permian. Like elsewhere in the region, the Permian magmatism in the NPIC could be associated with the rifting of the Cimmerian micro‐continents from the Gondwana.

Resource (Light and Nitrogen) and Density-Dependence of Seaweed Growth - Xi Xiao; Susana Agusti; Fang Lin; Caicai Xu; Yan Yu; Yaoru Pan; Ke Li; Jiaping Wu; Carlos M. Duarte (Frontiers in Marine Science, 2019)

Extended liquid chromatography high resolution mass spectrometry screening method for veterinary drug, pesticide and human pharmaceutical residues in aquaculture fish - Sherri B. Turnipseed; Joseph M. Storey; I-Lin Wu; Wendy C. Andersen; Mark R. Madson (Food Additives & Contaminants: Part A, 2019)

Simplified Tai Chi 6-Form Apparatus for Balance in Elderly People with Alzheimer’s Disease - Yin-Chou Lin; Wen-Chuin Hsu; Chien-Hung Chen; Chai-Wei Wang; Katie Pei-Hsuan Wu; Alice M. K. Wong (Journal of Medical and Biological Engineering, 2019)

The neural correlates of perceived energy levels in older adults with late-life depression - Charlene L. M. Lam; Ho-Ling Liu; Chih-Mao Huang; Yau-Yau Wai; Shwu-Hua Lee; Jenny Yiend; Chemin Lin; Tatia M. C. Lee (Brain Imaging and Behavior, 2019)

A direct comparison of divalent metal-ion transporter (DMT1) and hinokitiol, a potential small molecule replacement - Michael D. Garrick; Laura M. Garrick; Lin Zhao; James F. Collins; Joleen Soukup; Andrew J. Ghio (BioMetals, 2019)

Multi‐omic analyses of exogenous nutrient bag decomposition by the black morel Morchella importuna reveal sustained carbon acquisition and transferring - Hao Tan; Annegret Kohler; Renyun Miao; Tianhai Liu; Qiang Zhang; Bo Zhang; Lin Jiang; Yong Wang; Liyuan Xie; Jie Tang; Xiaolin Li; Lixu Liu; et al. (Environmental Microbiology, 2019)
Summary The black morel ( Morchella importuna Kuo, O'Donnell and Volk) was once an uncultivable wild mushroom, until the development of exogenous nutrient bag (ENB), making its agricultural production quite feasible and stable. To date, how the nutritional acquisition of the morel mycelium is fulfilled to trigger its fruiting remains unknown. To investigate the mechanisms involved in ENB decomposition, the genome of a cultivable morel strain ( M . importuna SCYDJ1‐A1) was sequenced and the genes coding for the decay apparatus were identified. Expression of the encoded carbohydrate‐active enzymes (CAZymes) was then analyzed by metatranscriptomics and metaproteomics in combination with biochemical assays. The results show that a diverse set of hydrolytic and redox CAZymes secreted by the morel mycelium is the main force driving the substrate decomposition. Plant polysaccharides such as starch and cellulose present in ENB substrate (wheat grains plus rice husks) were rapidly degraded, whereas triglycerides were accumulated initially and consumed later. ENB decomposition led to a rapid increase in the organic carbon content in the surface soil of the mushroom bed, which was thereafter consumed during morel fruiting. In contrast to the high carbon consumption, no significant acquisition of nitrogen was observed. Our findings contribute to an increasingly detailed portrait of molecular features triggering morel fruiting.

Crops For the Future (CFF): an overview of research efforts in the adoption of underutilised species - Peter J. Gregory; Sean Mayes; Chai Hui Hui; Ebrahim Jahanshiri; Advina Julkifle; Giva Kuppusamy; Ho Wai Kuan; Tan Xin Lin; Festo Massawe; T. A. S. T. M. Suhairi; Sayed N. Azam-Ali (Planta, 2019)

Repurposing Approved Drugs as Inhibitors of Kv7.1 and Nav1.8 to Treat Pitt Hopkins Syndrome - Sean Ekins; Jacob Gerlach; Kimberley M. Zorn; Brett M. Antonio; Zhixin Lin; Aaron Gerlach (Pharmaceutical Research, 2019)

The Long-Term Effects of Ethanol and Corticosterone on the Mood-Related Behaviours and the Balance Between Mature BDNF and proBDNF in Mice - L. Y. Lin; S. Y. Luo; M. Al-Hawwas; M. F. Herselman; X. F. Zhou; Larisa Bobrovskaya (Journal of Molecular Neuroscience, 2019)

Global Cloud-Resolving Models - Masaki Satoh; Bjorn Stevens; Falko Judt; Marat Khairoutdinov; Shian-Jiann Lin; William M. Putman; Peter Düben (Current Climate Change Reports, 2019)

Global in situ Observations of Essential Climate and Ocean Variables at the Air–Sea Interface - Luca R. Centurioni; Jon Turton; Rick Lumpkin; Lancelot Braasch; Gary Brassington; Yi Chao; Etienne Charpentier; Zhaohui Chen; Gary Corlett; Kathleen Dohan; Craig Donlon; Champika Gallage; et al. (Frontiers in Marine Science, 2019)

Global Perspectives on Observing Ocean Boundary Current Systems - Robert E. Todd; Francisco P. Chavez; Sophie Clayton; Sophie Cravatte; Marlos Goes; Michelle Graco; Xiaopei Lin; Janet Sprintall; Nathalie V. Zilberman; Matthew Archer; Javier Arístegui; Magdalena Balmaseda; et al. (Frontiers in Marine Science, 2019)

Development of polymorphic microsatellite markers for tree peony Paeonia delavayi (Paeoniaceae) using ddRAD-seq data - Shao-Lin Tan; Peter M. Hollingsworth; Han-Tao Qin; Lin-Jiang Ye; Jia-Yun Zou; Lian-Ming Gao (Molecular Biology Reports, 2019)

Noise exposure assessment and prevention around high-speed rail - K.-T. Tsai; M.-D. Lin; Y.-H. Lin (International Journal of Environmental Science and Technology, 2019)

Foundations and Frontiers of Ecosystem Science: Legacy of a Classic Paper (Odum 1969) - Jessica R. Corman; Scott L. Collins; Elizabeth M. Cook; Xiaoli Dong; Laureano A. Gherardi; Nancy B. Grimm; Rebecca L. Hale; Tao Lin; Jorge Ramos; Lara G. Reichmann; Osvaldo E. Sala (Ecosystems, 2019)

ARID1A, Prostaglandin E2, and Its Receptor as Possible Predictors of Malignant Transformation of the Endometrium in Endometriosis - A. S. Dyatlova; N. S. Lin’kova; V. O. Polyakova; N. G. Samoshkin; I. M. Kvetnoi (Bulletin of Experimental Biology and Medicine, 2019)

Ocean Climate Observing Requirements in Support of Climate Research and Climate Information - Detlef Stammer; Annalisa Bracco; Krishna AchutaRao; Lisa Beal; Nathaniel L. Bindoff; Pascale Braconnot; Wenju Cai; Dake Chen; Matthew Collins; Gokhan Danabasoglu; Boris Dewitte; Riccardo Farneti; et al. (Frontiers in Marine Science, 2019)

Ocean Observations in Support of Studies and Forecasts of Tropical and Extratropical Cyclones - Ricardo Domingues; Akira Kuwano-Yoshida; Patricia Chardon-Maldonado; Robert E. Todd; George Halliwell; Hyun-Sook Kim; I.-I. Lin; Katsufumi Sato; Tomoko Narazaki; Lynn K. Shay; Travis Miles; Scott Glenn; et al. (Frontiers in Marine Science, 2019)

Uncertainty analysis of rainfall depth duration frequency curves using the bootstrap resampling technique - Jing Lin Ng; Samsuzana Abd Aziz; Yuk Feng Huang; Majid Mirzaei; Aimrun Wayayok; M K Rowshon (Journal of Earth System Science, 2019)

Taxonomy of the order Mononegavirales: update 2019 - Gaya K. Amarasinghe; María A. Ayllón; Yīmíng Bào; Christopher F. Basler; Sina Bavari; Kim R. Blasdell; Thomas Briese; Paul A. Brown; Alexander Bukreyev; Anne Balkema-Buschmann; Ursula J. Buchholz; Camila Chabi-Jesus; et al. (Archives of Virology, 2019)

Long-term Nutrient Fertilization Increased Soil Carbon Storage in California Grasslands - Yang Lin; Eric W. Slessarev; Scott T. Yehl; Carla M. D’Antonio; Jennifer Y. King (Ecosystems, 2019)

Seasonal climatic effects and feedbacks of anthropogenic heat release due to global energy consumption with CAM5 - Bing Chen; C. Wu; X. Liu; L. Chen; Jian Wu; H. Yang; Tao Luo; Xue Wu; Yiquan Jiang; Lei Jiang; H. Y. Brown; Z. Lu; et al. (Climate Dynamics, 2019)

Limbic system structure volumes and associated neurocognitive functioning in former NFL players - Christian Lepage; Marc Muehlmann; Yorghos Tripodis; Jakob Hufschmidt; Julie Stamm; Katie Green; Pawel Wrobel; Vivian Schultz; Isabelle Weir; Michael L. Alosco; Christine M. Baugh; Nathan G. Fritts; et al. (Brain Imaging and Behavior, 2019)

Time-dependent shake map for Uttarakhand Himalayas, India, using recorded earthquakes - Himanshu Mittal; Yih-Min Wu; Ting-Li Lin; Cédric P. Legendre; Sushil Gupta; Benjamin M. Yang (Acta Geophysica, 2019)

The return of the frogs: The importance of habitat refugia in maintaining diversity during a disease outbreak - Donald T. McKnight; Monal M. Lal; Deborah S. Bower; Lin Schwarzkopf; Ross A. Alford; Kyall R. Zenger (Molecular Ecology, 2019)
Recent decades have seen the emergence and spread of numerous infectious diseases, often with severe negative consequences for wildlife populations. Nevertheless, many populations survive the initial outbreaks, and even undergo recoveries. Unfortunately, the long‐term effects of these outbreaks on host population genetics are poorly understood; to increase this understanding, we examined the population genetics of two species of rainforest frogs ( Litoria nannotis and Litoria serrata ) that have largely recovered from a chytridiomycosis outbreak at two national parks in the Wet Tropics of northern Australia. At the wetter, northern park there was little evidence of decreased genetic diversity in either species, and all of the sampled sites had high minor allele frequencies (mean MAF = 0.230–0.235), high heterozygosity (0.318–0.325), and few monomorphic markers (1.4%–4.0%); however, some recovered L. nannotis populations had low N e values (59.3–683.8) compared to populations that did not decline during the outbreak (1,537.4–1,756.5). At the drier, southern park, both species exhibited lower diversity (mean MAF = 0.084–0.180; heterozygosity = 0.126–0.257; monomorphic markers = 3.7%–43.5%; N e = 18.4–676.1). The diversity patterns in this park matched habitat patterns, with both species having higher diversity levels and fewer closely related individuals at sites with higher quality habitat. These patterns were more pronounced for L. nannotis, which has lower dispersal rates than L. serrata . These results suggest that refugia with high quality habitat are important for retaining genetic diversity during disease outbreaks, and that gene flow following disease outbreaks is important for re‐establishing diversity in populations where it was reduced.

Evaluation of the performance of IAP-AGCM4.1 in simulating the climate of West Africa - M. O. Adeniyi; Z. Lin; H. Zhang (Theoretical and Applied Climatology, 2019)

Skin Fibroblasts as the Object for Clinical Diagnosis of Parkinson’s Disease in Persons of Different Ages - V. A. Zuev; A. S. Dyatlova; N. S. Lin’kova; I. M. Kvetnoi; N. N. Belushkina; V. A. Pal’tsev (Bulletin of Experimental Biology and Medicine, 2019)

The complete genome of the antifungal bacterium Pseudomonas sp. strain MS82 - Lin Ma; Shaoxuan Qu; Jinsheng Lin; Jiayuan Jia; Sonya M. Baird; Ning Jiang; Huiping Li; Lijuan Hou; Shi-En Lu (Journal of Plant Diseases and Protection, 2019)

Taxonomy of the order Mononegavirales: second update 2018 - Piet Maes; Gaya K. Amarasinghe; María A. Ayllón; Christopher F. Basler; Sina Bavari; Kim R. Blasdell; Thomas Briese; Paul A. Brown; Alexander Bukreyev; Anne Balkema-Buschmann; Ursula J. Buchholz; Kartik Chandran; et al. (Archives of Virology, 2019)

A differential k-mer analysis pipeline for comparing RNA-Seq transcriptome and meta-transcriptome datasets without a reference - Chon-Kit Kenneth Chan; Nedeljka Rosic; Michał T. Lorenc; Paul Visendi; Meng Lin; Paulina Kaniewska; Brett J. Ferguson; Peter M. Gresshoff; Jacqueline Batley; David Edwards (Functional & Integrative Genomics, 2019)

On the coupling of convective updrafts prior to secondary eyewall formation in Hurricane Katrina (2005) - Jose M. Garcia-Rivera; Yuh-Lang Lin (Meteorology and Atmospheric Physics, 2019)

Understanding the evolving phenotype of vascular complications in telomere biology disorders - Cecilia Higgs; Yanick J. Crow; Denise M. Adams; Emmanuel Chang; Don Hayes; Utz Herbig; James N. Huang; Ryan Himes; Kunal Jajoo; F. Brad Johnson; Susan D. Reynolds; Yoshihiro Yonekawa; et al. (Angiogenesis, 2019)

Quantitative multi‐locus metabarcoding and waggle dance interpretation reveal honey bee spring foraging patterns in Midwest agroecosystems - Rodney T. Richardson; Hailey R. Curtis; Emma G. Matcham; Chia‐Hua Lin; Sreelakshmi Suresh; Douglas B. Sponsler; Luke E. Hearon; Reed M. Johnson (Molecular Ecology, 2019)
We explored the pollen foraging behaviour of honey bee colonies situated in the corn and soybean dominated agroecosystems of central Ohio over a month‐long period using both pollen metabarcoding and waggle dance inference of spatial foraging patterns. For molecular pollen analysis, we developed simple and cost‐effective laboratory and bioinformatics methods. Targeting four plant barcode loci (ITS2, rbcL , trnL and trnH ), we implemented metabarcoding library preparation and dual‐indexing protocols designed to minimize amplification biases and index mistagging events. We constructed comprehensive, curated reference databases for hierarchical taxonomic classification of metabarcoding data and used these databases to train the metaxa 2 DNA sequence classifier. Comparisons between morphological and molecular palynology provide strong support for the quantitative potential of multi‐locus metabarcoding. Results revealed consistent foraging habits between locations and show clear trends in the phenological progression of honey bee spring foraging in these agricultural areas. Our data suggest that three key taxa, woody Rosaceae such as pome fruits and hawthorns, Salix , and Trifolium provided the majority of pollen nutrition during the study. Spatially, these foraging patterns were associated with a significant preference for forests and tree lines relative to herbaceous land cover and nonflowering crop fields.

Longitudinal Neuroimaging Hippocampal Markers for Diagnosing Alzheimer’s Disease - Carlos Platero; Lin Lin; M. Carmen Tobar (Neuroinformatics, 2019)

What Promotes the Recovery of Salt Marsh Infauna After Oil Spills? - J. W. Fleeger; M. R. Riggio; I. A. Mendelssohn; Q. Lin; D. R. Deis; D. S. Johnson; K. R. Carman; S. A. Graham; S. Zengel; A. Hou (Estuaries and Coasts, 2019)

Unidirectional monosynaptic connections from auditory areas to the primary visual cortex in the marmoset monkey - Piotr Majka; Marcello G. P. Rosa; Shi Bai; Jonathan M. Chan; Bing-Xing Huo; Natalia Jermakow; Meng K. Lin; Yeonsook S. Takahashi; Ianina H. Wolkowicz; Katrina H. Worthy; Ramesh Rajan; David H. Reser; et al. (Brain Structure and Function, 2019)

Detection and quantification of Aeromonas schubertii in Channa maculata by TaqMan MGB probe fluorescence real‐time quantitative PCR - Chun Liu; Yanming M. Guo; Jizhen Z. Cao; De‐Feng Zhang; Ou‐Qin Chang; Kaibin Li; Fang Wang; Cun‐Bin Shi; Lan Jiang; Qing Wang; Li Lin (Journal of Fish Diseases, 2019)
Aeromonas schubertii is a major epidemiological agent that threatens cultured snakeheads ( Channidae ) and has caused great economic losses in fish‐farming industries in China in recent years. In present study, a specific TaqMan minor groove binder ( MGB ) probe fluorescence real‐time quantitative PCR ( qPCR ) assay was developed to rapidly detect and quantify A. schubertii . A pair of qPCR primers and a TaqMan MGB probe were selected from the rpoD gene, which were shown to be specific for A. schubertii . A high correlation coefficient ( R 2 = 0.9998) in a standard curve with a 103% efficiency was obtained. Moreover, the qPCR method's detection limit was as low as 18 copies/μl, which was 100 times more sensitive than that of conventional PCR . The detection results for the A. schubertii in pond water and fish tissue were consistent with those of the viable counts. Bacterial load changes detected by qPCR in different tissues of snakeheads infected with A. schubertii showed that the gills and intestines may be the entry for A. schubertii , and the spleen and kidney are major sites for A. schubertii replication. The established method in present study should be a useful tool for the early surveillance and quantitation of A. schubertii .

A genetic diversity assessment of Halymenia malaysiana (Halymeniaceae, Rhodophyta) from Malaysia and the Philippines based on COI-5P and rbcL sequences - Pui-Ling Tan; Phaik-Eem Lim; Showe-Mei Lin; Siew-Moi Phang; Stefano G.A. Draisma; Lawrence M. Liao (Journal of Applied Phycology, 2018)

Complete genome sequence of a novel sea otterpox virus - Jessica M. Jacob; Kuttichantran Subramaniam; Shin-Lin Tu; Ole Nielsen; Pamela A. Tuomi; Chris Upton; Thomas B. Waltzek (Virus Genes, 2018)

A geometric morphometric relationship predicts stone flake shape and size variability - Will Archer; Cornel M. Pop; Zeljko Rezek; Stefan Schlager; Sam C. Lin; Marcel Weiss; Tamara Dogandžić; Dawit Desta; Shannon P. McPherron (Archaeological and Anthropological Sciences, 2018)

Robust EEG/MEG Based Functional Connectivity with the Envelope of the Imaginary Coherence: Sensor Space Analysis - Jose M. Sanchez Bornot; KongFatt Wong-Lin; Alwani Liyana Ahmad; Girijesh Prasad (Brain Topography, 2018)

Effect of Subject-Specific Vertebral Position and Head and Neck Size on Calculation of Spine Musculoskeletal Moments - Anita N. Vasavada; Ellis Hughes; Derek D. Nevins; Steven M. Monda; David C. Lin (Annals of Biomedical Engineering, 2018)

Physicochemical and In Vitro Evaluation of Drug Delivery of an Antibacterial Synthetic Benzophenone in Biodegradable PLGA Nanoparticles - Gabriella Costabile; Kathrin I. Gasteyer; Venkatereddy Nadithe; Katherine Van Denburgh; Qian Lin; Shiv Sharma; Joshua J. Reineke; Steven M. Firestine; Olivia M. Merkel (AAPS PharmSciTech, 2018)

Metatranscriptome Profiling Indicates Size-Dependent Differentiation in Plastic and Conserved Community Traits and Functional Diversification in Dinoflagellate Communities - Sylke Wohlrab; Jan M. Falcke; Senjie Lin; Huan Zhang; Stefan Neuhaus; Stephanie Elferink; Daniela Voss; Oliver Zielinski; Uwe John (Frontiers in Marine Science, 2018)

Black race and distant recurrence after neoadjuvant or adjuvant chemotherapy in breast cancer - Jessica M. Pastoriza; George S. Karagiannis; Juan Lin; Sonali Lanjewar; David Entenberg; John S. Condeelis; Joseph A. Sparano; Xiaonan Xue; Thomas E. Rohan; Maja H. Oktay (Clinical & Experimental Metastasis, 2018)

Aeromonas shuberti as a cause of multi‐organ necrosis in internal organs of Nile tilapia, Oreochromis niloticus - C Liu; O Q Chang; D F Zhang; K B Li; F Wang; M H Lin; C B Shi; L Jiang; Q Wang; S M Bergmann (Journal of Fish Diseases, 2018)
A disease with white spots in internal organs of Nile tilapia occurred in Zhanjiang, southern China. Multiple, white nodules, 0.8–2.2 mm in diameter, were scattered throughout the liver, spleen and kidney of diseased fish. Signs of nodules reproduced after artificial infection with the isolated strain. Isolated bacteria were Gram‐negative, facultative anaerobic, motile, short rod‐shaped, with a length of 1.2–2.2 μm. Morphological and biochemical tests, as well as phylogenetic analysis, all strongly indicated that the isolate from tilapia is identical to Aeromonas schubertii ( A. schubertii) which temporary named LF 1708 strain. Antibiotic sensitivity assays showed the LF 1708 is sensitive to 24 of 27 tested antibiotics. Pathogenicity test revealed that the isolate at the dose of 3.75 × 10 6 CFU /g killed 100% of experimental tilapia within 2 days and the dose of 1 × 10 7 CFU /g killed 100% of experimental zebrafish within 1 day. Histopathology of diseased tilapia infected with A. schubertii showed numerous necrotic lesions widely distributed in spleen, liver and kidney, and infiltration with a large number of bacteria. To our knowledge, this was the first report that associated A. schubertii with mortality in tilapia.

Cover Image - X Luo; G Liao; C Liu; X Jiang; M Lin; C Zhao; J Tao; Z Huang (Journal of Fish Diseases, 2018)

Characterization of bacteriophage HN 48 and its protective effects in Nile tilapia Oreochromis niloticus against Streptococcus agalactiae infections - X Luo; G Liao; C Liu; X Jiang; M Lin; C Zhao; J Tao; Z Huang (Journal of Fish Diseases, 2018)
Streptococcus agalactiae is a causative agent responsible for massive mortalities of tilapia that has led to catastrophic losses to tilapia culture globally. Bacteriophages represent a new class of antimicrobials against bacteria. In this study, we characterized the bacteriophage HN 48, which formed small and round‐transparent plaques on a double‐layer plate. With a hexagonal head and a long tail, this phage may belong to the Caudovirales according to the International Committee on Taxonomy of Viruses. HN 48 was found to have a relatively wide and highly specific host range, to be sensitive to high temperature (60–80°C) and low pH (3–5), and to be relatively stable at alkaline pH (8–10). Intraperitoneal injection with HN 48 had no adverse effects on tilapia and effectively inactivated the bacteria in the kidney. Fish that received phage therapy had 60% ± 3.3% survival rates and a delayed mean death time of about 3 days when compared to the control group. To the best of knowledge, this is the first study of tilapia streptococcal phage. Overall, the results indicated that phage HN 48 could prevent tilapia from experimental S. agalactiae infection, suggesting it has the potential to control this disease.

Patterns and drivers of species diversity in the Indo‐Pacific red seaweed Portieria - Frederik Leliaert; Dioli Ann Payo; Carlos Frederico D. Gurgel; Tom Schils; Stefano G. A. Draisma; Gary W. Saunders; Mitsunobu Kamiya; Alison R. Sherwood; Showe‐Mei Lin; John M. Huisman; Line Le Gall; Robert J. Anderson; et al. (Journal of Biogeography, 2018)
Aim Biogeographical processes underlying Indo‐Pacific biodiversity patterns have been relatively well studied in marine shallow water invertebrates and fishes, but have been explored much less extensively in seaweeds, despite these organisms often displaying markedly different patterns. Using the marine red alga Portieria as a model, we aim to gain understanding of the evolutionary processes generating seaweed biogeographical patterns. Our results will be evaluated and compared with known patterns and processes in animals. Location Indo‐Pacific marine region. Methods Species diversity estimates were inferred using DNA ‐based species delimitation methods. Historical biogeographical patterns were inferred based on a six‐gene time‐calibrated phylogeny, distribution data of 802 specimens, and probabilistic modelling of geographical range evolution. The importance of geographical isolation for speciation was further evaluated by population genetic analyses at the intraspecific level. Results We delimited 92 candidate species, most with restricted distributions, suggesting low dispersal capacity. Highest species diversity was found in the Indo‐Malay Archipelago ( IMA ). Our phylogeny indicates that Portieria originated during the late Cretaceous in the area that is now the Central Indo‐Pacific. The biogeographical history of Portieria includes repeated dispersal events to peripheral regions, followed by long‐term persistence and diversification of lineages within those regions, and limited dispersal back to the IMA . Main conclusions Our results suggest that the long geological history of the IMA played an important role in shaping Portieria diversity. High species richness in the IMA resulted from a combination of speciation at small spatial scales, possibly as a result of increased regional habitat diversity from the Eocene onwards, and species accumulation via dispersal and/or island integration through tectonic movement. Our results are consistent with the biodiversity feedback model, in which biodiversity hotspots act as both “centres of origin” and “centres of accumulation,” and corroborate previous findings for invertebrates and fish that there is no single unifying model explaining the biological diversity within the IMA .

Simulating Effects of Variable Stoichiometry and Temperature on Mixotrophy in the Harmful Dinoflagellate Karlodinium veneficum - Chih-Hsien Lin; Kevin J. Flynn; Aditee Mitra; Patricia M. Glibert (Frontiers in Marine Science, 2018)

A Comparative Placebo-Controlled Clinical Trial of the Efficacy and Safety of Interferon β-1a Formulations for S.C. Administration in Patients with Remitting Multiple Sclerosis: First-Year Results - A. N. Boiko; L. P. Bosenko; V. V. Vasilovskii; L. I. Volkova; M. N. Zakharova; S. V. Kotov; E. V. Lekomtseva; T. I. Negrich; E. V. Parshina; O. P. Patrusheva; S. V. Prokopenko; D. V. Sazonov; et al. (Neuroscience and Behavioral Physiology, 2018)

Enhancement of photocatalytic activity of titanium dioxide using non-metal doping methods under visible light: a review - M. Nasirian; Y. P. Lin; C. F. Bustillo-Lecompte; M. Mehrvar (International Journal of Environmental Science and Technology, 2018)

Resistance to neomycin ototoxicity in the extreme basal (hook) region of the mouse cochlea - Shelly C. Y. Lin; Peter R. Thorne; Gary D. Housley; Srdjan M. Vlajkovic (Histochemistry and Cell Biology, 2018)

Taxonomy of the order Mononegavirales: update 2018 - Gaya K. Amarasinghe; Nidia G. Aréchiga Ceballos; Ashley C. Banyard; Christopher F. Basler; Sina Bavari; Andrew J. Bennett; Kim R. Blasdell; Thomas Briese; Alexander Bukreyev; Yíngyún Caì; Charles H. Calisher; Cristine Campos Lawson; et al. (Archives of Virology, 2018)

Modeling of the strong ground motion of 25th April 2015 Nepal earthquake using modified semi-empirical technique - Sohan Lal; A. Joshi; Sandeep; Monu Tomer; Parveen Kumar; Chun-Hsiang Kuo; Che-Min Lin; Kuo-Liang Wen; M. L. Sharma (Acta Geophysica, 2018)

Transcriptional responses of the marine green alga Micromonas pusilla and an infecting prasinovirus under different phosphate conditions - Charles Bachy; Christina J. Charlesworth; Amy M. Chan; Jan F. Finke; Chee‐Hong Wong; Chia‐Lin Wei; Sebastian Sudek; Maureen L. Coleman; Curtis A. Suttle; Alexandra Z. Worden (Environmental Microbiology, 2018)
Summary Prasinophytes are widespread marine algae for which responses to nutrient limitation and viral infection are not well understood. We studied the picoprasinophyte, Micromonas pusilla , grown under phosphate‐replete (0.65 ± 0.07 d −1 ) and 10‐fold lower (low)‐phosphate (0.11 ± 0.04 d −1 ) conditions, and infected by the phycodnavirus MpV‐SP1. Expression of 17% of Micromonas genes in uninfected cells differed by >1.5‐fold ( q

Mechanisms of influence of invasive grass litter on germination and growth of coexisting species in California - Bao-Ming Chen; Carla M. D’Antonio; Nicole Molinari; Shao-Lin Peng (Biological Invasions, 2018)

Diurnal changes of cyanobacteria blooms in Taihu Lake as derived from GOCI observations - Lin Qi; Chuanmin Hu; Petra M. Visser; Ronghua Ma (Limnology and Oceanography, 2018)
Using frequent and long‐term measurements (eight times per day, 2011 to present) from a geostationary satellite sensor (Geostationary Ocean Color Imager, GOCI), this study investigates diurnal changes of cyanobacterium Microcystis aeruginosa blooms (near‐surface high concentrations or surface scums) in Taihu Lake, from which vertical migration patterns could be inferred. After proper atmospheric correction, a cyanobacterial index algorithm is used to quantify equivalent surface cyanobacterial density ( σ , 0–100%) at both pixel and synoptic scales from each cloud‐free image, followed by analysis of diurnal changing patterns of σ at both scales. Three typical diurnal changing patterns are identified from all images, which show distinctive and different seasonality from the long‐term statistics. Spatial distributions of the “hotspot” regions where diurnal changes are most often observed have also been established. While the seasonality of the three patterns appears to be a result of seasonality in both temperature and light availability, large blooms only occur 1 d after major wind events. Based on several lines of evidence, we hypothesize that the diurnal changes of such observed surface bloom patterns are likely a result of vertical migration rather than horizontal dissipation/aggregation of cyanobacteria. The mean migration speeds inferred from either a simple model or a radiative transfer model ( −1 or −1 ) are consistent with those reported earlier from laboratory measurements for certain cyanobacteria colony sizes. Complete understanding of the three types of diurnal patterns and direct validation of the hypothesis, however, require further investigations from field measurements.

Front Cover - James A. Lutz; Tucker J. Furniss; Daniel J. Johnson; Stuart J. Davies; David Allen; Alfonso Alonso; Kristina J. Anderson‐Teixeira; Ana Andrade; Jennifer Baltzer; Kendall M. L. Becker; Erika M. Blomdahl; Norman A. Bourg; et al. (Global Ecology and Biogeography, 2018)

Global importance of large‐diameter trees - James A. Lutz; Tucker J. Furniss; Daniel J. Johnson; Stuart J. Davies; David Allen; Alfonso Alonso; Kristina J. Anderson‐Teixeira; Ana Andrade; Jennifer Baltzer; Kendall M. L. Becker; Erika M. Blomdahl; Norman A. Bourg; et al. (Global Ecology and Biogeography, 2018)
Aim To examine the contribution of large‐diameter trees to biomass, stand structure, and species richness across forest biomes. Location Global. Time period Early 21st century. Major taxa studied Woody plants. Methods We examined the contribution of large trees to forest density, richness and biomass using a global network of 48 large (from 2 to 60 ha) forest plots representing 5,601,473 stems across 9,298 species and 210 plant families. This contribution was assessed using three metrics: the largest 1% of trees ≥ 1 cm diameter at breast height (DBH), all trees ≥ 60 cm DBH, and those rank‐ordered largest trees that cumulatively comprise 50% of forest biomass. Results Averaged across these 48 forest plots, the largest 1% of trees ≥ 1 cm DBH comprised 50% of aboveground live biomass, with hectare‐scale standard deviation of 26%. Trees ≥ 60 cm DBH comprised 41% of aboveground live tree biomass. The size of the largest trees correlated with total forest biomass ( r 2 = .62, p r 2 = .45, p r 2 = .33, p r 2 = .17, p = .002). The concentration of biomass in the largest 1% of trees declined with increasing absolute latitude ( r 2 = .46, p r 2 = .31, p r 2 = .26, p Main conclusions Because large‐diameter trees constitute roughly half of the mature forest biomass worldwide, their dynamics and sensitivities to environmental change represent potentially large controls on global forest carbon cycling. We recommend managing forests for conservation of existing large‐diameter trees or those that can soon reach large diameters as a simple way to conserve and potentially enhance ecosystem services.

DNA Barcoding for Identification of Sugarcane Borers in China - J- D Wang; W- Z Wang; Z- L Lin; A Ali; H- Y Fu; M- T Huang; S- J Gao; R Wang (Neotropical Entomology, 2018)

Trade-offs between defence and competition in gregarious juvenile fluted giant clams (Tridacna squamosa L.) - Darren Z. H. Sim; Mei Lin Neo; Ambert C. F. Ang; Lynette S. M. Ying; Peter A. Todd (Marine Biology, 2018)

Burly1 is a mouse QTL for lean body mass that maps to a 0.8-Mb region of chromosome 2 - Cailu Lin; Brad D. Fesi; Michael Marquis; Natalia P. Bosak; Anna Lysenko; Mohammed Amin Koshnevisan; Fujiko F. Duke; Maria L. Theodorides; Theodore M. Nelson; Amanda H. McDaniel; Mauricio Avigdor; Charles J. Arayata; et al. (Mammalian Genome, 2018)

Association between anti-tuberculosis drug resistance-conferring mutations and treatment outcomes in Myanmar - Htin Lin Aung; Thanda Tun; Wint Wint Nyunt; Yang Fong; John A. Crump; Kyi Kyi Thinn; Si Thu Aung; Gregory M. Cook (Infectious Diseases, 2018)

Synthesis of nucleobase-neomycin conjugates and evaluation of their DNA binding, cytotoxicities, and antibacterial properties - Siwen Wang; Mandeep Singh; Mingheng Ling; Danni Li; Krege M. Christison; Joan Lin-Cereghino; Geoff P. Lin-Cereghino; Liang Xue (Medicinal Chemistry Research, 2018)

Examination of gene repertoires and physiological responses to iron and light limitation in Southern Ocean diatoms - Carly M. Moreno; Yajuan Lin; Sarah Davies; Elaine Monbureau; Nicolas Cassar; Adrian Marchetti (Polar Biology, 2018)

Correction to: Functional near-infrared spectroscopy (fNIRS) brain imaging of multi-sensory integration during computerized dynamic posturography in middle-aged and older adults - Chia-Cheng Lin; Jeffrey W. Barker; Patrick J. Sparto; Joseph M. Furman; Theodore J. Huppert (Experimental Brain Research, 2018)

Rice ecosystem services in South-east Asia - Josef Settele; Kong Luen Heong; Ingolf Kühn; Stefan Klotz; Joachim H. Spangenberg; Gertrudo Arida; Alexis Beaurepaire; Silke Beck; Erwin Bergmeier; Benjamin Burkhard; Roland Brandl; Jesus Victor Bustamante; et al. (Paddy and Water Environment, 2018)

Temporal Profile and Severity Correlation of a Panel of Rat Spinal Cord Injury Protein Biomarkers - Zhihui Yang; Helen M. Bramlett; Ahmed Moghieb; Dongnan Yu; Ping Wang; Fan Lin; Carl Bauer; Tyler M. Selig; Emily Jaalouk; Amanda S. Weissman; Disa S. Rathore; Pammela Romo; et al. (Molecular Neurobiology, 2018)

Glucohexaose-induced protein phosphatase 2C regulates cell redox status of cucumber seedling - Q M Chen; Y Yu; C M Lin; N Cui; J Y Zhao; T F Song; H Y Fan (Journal of Biosciences, 2018)

Morphological but no genetic differentiation among fragmented populations of Hemiculter leucisculus (Actinopterygii, Cyprinidae) from a lake complex in the middle Yangtze, China - Fei Cheng; Shuaibing Zhao; Bjorn V. Schmidt; Lin Ye; Eric M. Hallerman; Songguang Xie (Hydrobiologia, 2018)

Matrix Metalloproteinases MMP-1 and MMP-9 and Their Inhibitor TIMP-1 as Markers of Dilated Cardiomyopathy in Patients of Different Age - I. B. Antonov; K. L. Kozlov; E. M. Pal’tseva; O. V. Polyakova; N. S. Lin’kova (Bulletin of Experimental Biology and Medicine, 2018)

The Benefits of Reduced Anthropogenic Climate changE (BRACE): a synthesis - Brian C. O’Neill; James M. Done; Andrew Gettelman; Peter Lawrence; Flavio Lehner; Jean-Francois Lamarque; Lei Lin; Andrew J. Monaghan; Keith Oleson; Xiaolin Ren; Benjamin M. Sanderson; Claudia Tebaldi; et al. (Climatic Change, 2018)

Aerosol microphysical and radiative effects on continental cloud ensembles - Yuan Wang; Jonathan M. Vogel; Yun Lin; Bowen Pan; Jiaxi Hu; Yangang Liu; Xiquan Dong; Jonathan H. Jiang; Yuk L. Yung; Renyi Zhang (Advances in Atmospheric Sciences, 2018)

Characterizing the neighborhood obesogenic environment in the Multiethnic Cohort: a multi-level infrastructure for cancer health disparities research - Shannon M. Conroy; Salma Shariff-Marco; Juan Yang; Andrew Hertz; Myles Cockburn; Yurii B. Shvetsov; Christina A. Clarke; Cheryl L. Abright; Christopher A. Haiman; Loïc Le Marchand; Laurence N. Kolonel; Kristine R. Monroe; et al. (Cancer Causes & Control, 2018)

Riding the Kuroshio Current: Stepping stone dispersal of the Okinawa tree lizard across the East Asian Island Arc - Shang‐Fang Yang; Shohei Komaki; Rafe M. Brown; Si‐Min Lin (Journal of Biogeography, 2018)
Aim Located hundreds of kilometres offshore of continental mainland Asia, the extremely high level of land vertebrate endemism in the East Asian Island Arc provides an excellent opportunity to test hypotheses regarding biogeographic processes and speciation. In this study, we aim to test alternative explanations for lineage diversification (vicariance versus dispersal models), and further develop a temporal framework for diversification in our focal taxon, which is consistent with the known age of these islands. We achieve these tests by investigating the historical biogeography of the Okinawa tree lizard ( Japalura polygonata ), one of the few widely‐distributed reptiles across this archipelago. Location The East Asian Island Arc: (1) Central Ryukyu (Amami and Okinawa groups); (2) Southern Ryukyu (Miyako and Yaeyama groups); (3) Taiwan and adjacent islands. Methods A total of 246 tissues were sampled from 10 localities in the Ryukyu archipelago and 17 localities in Taiwan, covering the entire distributional range of this species, including all subspecies. DNA sequences of the mitochondrial cytochrome b , 16S ribosomal RNA , nuclear BACH ‐1 and RAG ‐1 genes (total: 4,684 bp) were obtained from these samples. We used maximum likelihood and Bayesian methods to infer phylogeny and divergence time, and used a model‐fitting method of biogeographical inference to estimate ancestral range evolution. Results Multiple lines of evidence combine to identify a general pattern of dispersal‐mediated diversification northward through the archipelago, following initial dispersal from Taiwan. These included (1) a phylogenetic estimate, revealing a sequential, south‐to‐north branching pattern; (2) ancestral range estimation, inferring multiple overseas dispersals and subsequent colonization of new landmasses; and (3) a reduction in genetic variation observed in successively‐diverging lineages, decreasing from Taiwan northward, towards more remote islands. These results provide strong statistical support for an interpretation of successive bouts of dispersal via the powerful, well‐documented, south‐to‐north Kuroshio Current. Estimation of divergence times suggests that most clades in southern Ryukyu and Taiwan diverged early, giving rise to lineages that have remained isolated, and that more recently‐diverged lineages then colonized northward to subsequently occupy the landmasses of the Central Ryukyu archipelago. Main conclusions Our general inference of biogeographic history in Japalura polygonata suggested that this species originated on Taiwan and the Yaeyama group, and arrived at its current distribution in Miyako, Okinawa, Toku and Amami islands by a series of stepping‐stone dispersals, which we report for the first time for a terrestrial vertebrate endemic to this region.

Complex inter‐island colonization and peripatric founder speciation promote diversification of flightless Pachyrhynchus weevils in the Taiwan–Luzon volcanic belt - Hui‐Yun Tseng; Wen‐San Huang; Ming‐Luen Jeng; Reagan Joseph T. Villanueva; Olga M. Nuñeza; Chung‐Ping Lin (Journal of Biogeography, 2018)
Aim We investigated the spatial and temporal patterns of diversification among colourful and flightless weevils, the Pachyrhynchus orbifer complex, to test the stepping‐stone hypothesis of colonization across the Taiwan–Luzon volcanic belt. Location Southeast Asia. Methods The phylogeny of the P. orbifer complex was reconstructed from a multi‐locus data set of mitochondrial and nuclear genes using maximum likelihood in RAxML and Bayesian inference in MRBAYES. Likelihood‐based tests in CONSEL were used to evaluate alternative tree topologies. Divergence times were estimated in beast based on a range of mutation rates. Ancestral range and biogeographical history were reconstructed using Bayesian binary MCMC ( BBM ) methods in RASP and in BioGeoBEARS. Demographic histories were inferred using the extended Bayesian skyline plot ( EBSP ). Species boundaries were tested using BPP. Results The phylogeny of the P. orbifer complex indicated strong support for seven reciprocally monophyletic lineages grouped by current island boundaries (Camiguin, Fuga, Dalupiri, Calayan, Babuyan, Orchid and Yaeyama Islands), except for a sister Green + Itbayat lineage. Complex and stochastic colonization of P. orbifer was inferred to have involved both northward and southward directions with short‐ and long‐distance dispersal events, which are strongly inconsistent with the strict stepping‐stone hypothesis. Divergence time estimates for all extant island lineages ( c . 3 Myr) of the islands. The statistically delimited seven cryptic species imply that the diversity of Pachyrhynchus from small peripheral islands continues to be largely under‐estimated. Main conclusions The non‐linear, more complex spatial and temporal settings of the archipelago and stochastic dispersal were probable key factors shaping the colonization history of the P. orbifer complex. Speciation of the P. orbifer complex may have occurred only between islands, indicating that peripatric speciation through the founders of stochastic dispersals was the major evolutionary driver.

Evaluation of the genotype MTBDR sl test for detection of second-line drug resistance in drug-resistant Mycobacterium tuberculosis strains in Myanmar - Wint Wint Nyunt; Si Thu Aung; Gregory M. Cook; Htin Lin Aung (Infectious Diseases, 2017)

Approaches for Establishing Clinically Relevant Dissolution Specifications for Immediate Release Solid Oral Dosage Forms - Andre Hermans; Andreas M. Abend; Filippos Kesisoglou; Talia Flanagan; Michael J. Cohen; Dorys A. Diaz; Y. Mao; Limin Zhang; Gregory K. Webster; Yiqing Lin; David A. Hahn; Carrie A. Coutant; et al. (The AAPS Journal, 2017)

Stochastic modelling of seasonal and yearly rainfalls with low-frequency variability - Jing Lin Ng; Samsuzana Abd Aziz; Yuk Feng Huang; Aimrun Wayayok; M. K. Rowshon (Stochastic Environmental Research and Risk Assessment, 2017)

Effects of Ganoderma Lucidum shell-broken spore on oxidative stress of the rabbit urinary bladder using an in vivo model of ischemia/reperfusion - Robert M. Levin; Li Xia; Wu Wei; Catherine Schuler; Robert E. Leggett; Alpha D.-Y. Lin (Molecular and Cellular Biochemistry, 2017)

Acclimation of bloom‐forming and perennial seaweeds to elevated p CO 2 conserved across levels of environmental complexity - Dong Xu; Charlotte‐Elisa Schaum; Fan Lin; Ke Sun; James R. Munroe; Xiao W. Zhang; Xiao Fan; Lin H. Teng; Yi T. Wang; Zhi M. Zhuang; Naihao Ye (Global Change Biology, 2017)
Macroalgae contribute approximately 15% of the primary productivity in coastal marine ecosystems, fix up to 27.4 Tg of carbon per year, and provide important structural components for life in coastal waters. Despite this ecological and commercial importance, direct measurements and comparisons of the short‐term responses to elevated p CO 2 in seaweeds with different life‐history strategies are scarce. Here, we cultured several seaweed species (bloom forming/nonbloom forming/perennial/annual) in the laboratory, in tanks in an indoor mesocosm facility, and in coastal mesocosms under p CO 2 levels ranging from 400 to 2,000 μatm. We find that, across all scales of the experimental setup, ephemeral species of the genus Ulva increase their photosynthesis and growth rates in response to elevated p CO 2 the most, whereas longer‐lived perennial species show a smaller increase or a decrease. These differences in short‐term growth and photosynthesis rates are likely to give bloom‐forming green seaweeds a competitive advantage in mixed communities, and our results thus suggest that coastal seaweed assemblages in eutrophic waters may undergo an initial shift toward communities dominated by bloom‐forming, short‐lived seaweeds.

Hypoxia inducible factor (HIF) in the tumor microenvironment: friend or foe? - Yanqing Huang; Daniel Lin; Cullen M. Taniguchi (Science China Life Sciences, 2017)

Ischemic Post-Conditioning Induces Post-Stroke Neuroprotection via Hsp70-Mediated Proteasome Inhibition and Facilitates Neural Progenitor Cell Transplantation - Thorsten R. Doeppner; Maria Doehring; Britta Kaltwasser; Arshad Majid; Fengyan Lin; Mathias Bähr; Ertugrul Kilic; Dirk M. Hermann (Molecular Neurobiology, 2017)

Role of LIF Cytokine and CD34 Angiogenesis Marker in Non-Developing Pregnancy - E. S. Popravka; A. S. Dyatlova; N. S. Lin’kova; Yu. S. Krylova; V. O. Polyakova; I. M. Kvetnoi (Bulletin of Experimental Biology and Medicine, 2017)

Methylmalonate‐semialdehyde dehydrogenase mediated metabolite homeostasis essentially regulate conidiation, polarized germination and pathogenesis in Magnaporthe oryzae - Justice Norvienyeku; Zhenhui Zhong; Lili Lin; Xie Dang; Meilian Chen; Xiaolian Lin; Honghong Zhang; Wilfred M. Anjago; Lianyu Lin; Waheed Abdul; Zonghua Wang (Environmental Microbiology, 2017)
Summary Plants generate multitude of aldehydes under abiotic and biotic stress conditions. Ample demonstrations have shown that rice‐derived aldehydes enhance the resistance of rice against the rice‐blast fungus Magnaporthe oryzae . However, how the fungal pathogen nullifies the inhibitory effects of host aldehydes to establish compatible interaction remains unknown. Here we identified and evaluated the in vivo transcriptional activities of M. oryzae aldehyde dehydrogenase (ALDH) genes. Transcriptional analysis of M. oryzae ALDH genes revealed that the acetylating enzyme Methylmalonate‐Semialdehyde Dehydrogenase (MoMsdh/MoMmsdh) elevated activities during host invasion and colonization of the fungus. We further examined the pathophysiological importance of MoMSDH by deploying integrated functional genetics, and biochemical approaches. MoMSDH deletion mutant Δ Momsdh exhibited germination defect, hyper‐branching of germ tube and failed to form appressoria on hydrophobic and hydrophilic surface. The MoMSDH disruption caused accumulation of small branch‐chain amino acids, pyridoxine and AMP/cAMP in the Δ Momsdh mutant and altered Spitzenkörper organization in the conidia. We concluded that MoMSDH contribute significantly to the pathogenesis of M. oryzae by regulating the mobilization of Spitzenkörper during germ tube morphogenesis, appressoria formation by acting as metabolic switch regulating small branch‐chain amino acids, inositol, pyridoxine and AMP/cAMP homeostasis.

Development of a two-stage washing and biodegradation system to remediate octachlorinated dibenzo-p-dioxin-contaminated soils - J. L. Lin; C. D. Dong; C. W. Chen; S. H. Chen; T. E. Hsieh; C. M. Kao (International Journal of Environmental Science and Technology, 2017)

Formation of chlorite rims and the impact of pore-lining chlorite on reservoir quality: a case study from Shiqianfeng sandstones in upper Permian of Dongpu Depression, Bohai Bay Basin, eastern China - P. J. Ma; C. Y. Lin; S. Q. Zhang; C. M. Dong; Y. F. Xu (Australian Journal of Earth Sciences, 2017)

Evolution of landslide hotspots in Taiwan - S. C. Lin; M. C. Ke; C. M. Lo (Landslides, 2017)

Racial differences in the effects of comorbidity on breast cancer-specific survival - Melissa L. Santorelli; Kim M. Hirshfield; Michael B. Steinberg; Yong Lin; George G. Rhoads; Elisa V. Bandera; Kitaw Demissie (Cancer Causes & Control, 2017)

Taxonomy of the order Mononegavirales: update 2017 - Gaya K. Amarasinghe; Yīmíng Bào; Christopher F. Basler; Sina Bavari; Martin Beer; Nicolás Bejerman; Kim R. Blasdell; Alisa Bochnowski; Thomas Briese; Alexander Bukreyev; Charles H. Calisher; Kartik Chandran; et al. (Archives of Virology, 2017)

Analysis of tandem repeat units of the promoter of capsanthin/capsorubin synthase (Ccs) gene in pepper fruit - Shi-Lin Tian; Zheng Li; Li Li; S. N. M. Shah; Zhen-Hui Gong (Physiology and Molecular Biology of Plants, 2017)

Cardiotoxicity Associated with Nicotinamide Phosphoribosyltransferase Inhibitors in Rodents and in Rat and Human-Derived Cells Lines - D. L. Misner; M. A. Kauss; J. Singh; H. Uppal; A. Bruening-Wright; B. M. Liederer; T. Lin; B. McCray; N. La; T. Nguyen; D. Sampath; P. S. Dragovich; et al. (Cardiovascular Toxicology, 2017)

Midgut morphological changes and autophagy during metamorphosis in sand flies - Juliana Malta; Matthew Heerman; Ju Lin Weng; Kenner M. Fernandes; Gustavo Ferreira Martins; Marcelo Ramalho-Ortigão (Cell and Tissue Research, 2017)

CRISPR-Cas9 and CRISPR-Cpf1 mediated targeting of a stomatal developmental gene EPFL9 in rice - Xiaojia Yin; Akshaya K. Biswal; Jacqueline Dionora; Kristel M. Perdigon; Christian P. Balahadia; Shamik Mazumdar; Caspar Chater; Hsiang-Chun Lin; Robert A. Coe; Tobias Kretzschmar; Julie E. Gray; Paul W. Quick; et al. (Plant Cell Reports, 2017)

Genetic Variants of Microtubule Actin Cross-linking Factor 1 (MACF1) Confer Risk for Parkinson’s Disease - Xin Wang; Nuomin Li; Nian Xiong; Qi You; Jie Li; Jinlong Yu; Hong Qing; Tao Wang; Heather J. Cordell; Ole Isacson; Jeffery M. Vance; Eden R. Martin; et al. (Molecular Neurobiology, 2017)

Gonorrhea infection increases the risk of prostate cancer in Asian population: a nationwide population-based cohort study - Y.-C. Wang; C.-H. Chung; J.-H. Chen; M.-H. Chiang; Ti-Yin; C.-H. Tsao; F.-H. Lin; W.-C. Chien; S.-T. Shang; F.-Y. Chang (European Journal of Clinical Microbiology & Infectious Diseases, 2017)

Endometriosis and risk of ovarian and endometrial cancers in a large prospective cohort of U.S. nurses - Elizabeth M. Poole; Wayne T. Lin; Marina Kvaskoff; Immaculata De Vivo; Kathryn L. Terry; Stacey A. Missmer (Cancer Causes & Control, 2017)

Prior Visual Experience Modulates Learning of Sound Localization Among Blind Individuals - Qian Tao; Chetwyn C. H. Chan; Yue-jia Luo; Jian-jun Li; Kin-hung Ting; Zhong-lin Lu; Susan Whitfield-Gabrieli; Jun Wang; Tatia M. C. Lee (Brain Topography, 2017)

Functional near-infrared spectroscopy (fNIRS) brain imaging of multi-sensory integration during computerized dynamic posturography in middle-aged and older adults - Chia-Cheng Lin; Jeffrey W. Barker; Patrick J. Sparto; Joseph M. Furman; Theodore J. Huppert (Experimental Brain Research, 2017)

Soil priming effects following substrates addition to biochar-treated soils after 431 days of pre-incubation - Yu Luo; Qimei Lin; M. Durenkamp; A. J. Dungait; P. C. Brookes (Biology and Fertility of Soils, 2017)

Effects of dietary canthaxanthin on growth and body colour of blood parrot cichlid Amphilophus citrinellus × Paraneetroplus synspilus - M. Li; M. M. Rahman; B. Wu; Y.-C. Lin (Aquaculture International, 2017)

Genotypic diversity of Mycobacterium tuberculosis strains in Myanmar - Thanda Tun; Khin Saw Aye; Wint Wint Nyunt; John A. Crump; Chie Nakajima; Yasuhiko Suzuki; Kyi Kyi Thinn; Gregory M. Cook; Htin Lin Aung (Infectious Diseases, 2017)

Internet Usage Trends in Thoracic Surgery Patients and Their Caregivers - Alisha D. Lussiez; Stephanie Burdick; Sindhura Kodali; Gustavo Rubio; Jacob A. Mack; Jules Lin; Andrew C. Chang; Rishindra M. Reddy (Journal of Cancer Education, 2017)

Composite likelihood approach to the regression analysis of spatial multivariate ordinal data and spatial compositional data with exact zero values - Xiaoping Feng; Jun Zhu; Pei-Sheng Lin; Michelle M. Steen-Adams (Environmental and Ecological Statistics, 2017)

Nitrogen footprints: Regional realities and options to reduce nitrogen loss to the environment - Hideaki Shibata; James N. Galloway; Allison M. Leach; Lia R. Cattaneo; Laura Cattell Noll; Jan Willem Erisman; Baojing Gu; Xia Liang; Kentaro Hayashi; Lin Ma; Tommy Dalgaard; Morten Graversgaard; et al. (Ambio, 2017)

Variability of hydrological extreme events in East Asia and their dynamical control: a comparison between observations and two high-resolution global climate models - N. Freychet; A. Duchez; C.-H. Wu; C.-A. Chen; H.-H. Hsu; J. Hirschi; A. Forryan; B. Sinha; A. L. New; T. Graham; M. B. Andrews; C.-Y. Tu; et al. (Climate Dynamics, 2017)

Recent declines in cancer incidence: related to the Great Recession? - Scarlett Lin Gomez; Alison J. Canchola; David O. Nelson; Theresa H. M. Keegan; Christina A. Clarke; Iona Cheng; Salma Shariff-Marco; Mindy DeRouen; Ralph Catalano; William A. Satariano; Kathleen Davidson-Allen; Sally L. Glaser (Cancer Causes & Control, 2017)

Angiopoietins as serum biomarkers for lymphatic anomalies - Timothy D. Le Cras; Paula S. Mobberley-Schuman; Mary Broering; Lin Fei; Cameron C. Trenor; Denise M. Adams (Angiogenesis, 2017)

Development and Translational Application of an Integrated, Mechanistic Model of Antibody-Drug Conjugate Pharmacokinetics - Siddharth Sukumaran; Crystal Zhang; Douglas D. Leipold; Ola M. Saad; Keyang Xu; Kapil Gadkar; Divya Samineni; Bei Wang; Marija Milojic-Blair; Montserrat Carrasco-Triguero; Bonnee Rubinfeld; Paul Fielder; et al. (The AAPS Journal, 2017)

Microwave drying characteristics of microalgae (Chlorella vulgaris) for biofuel production - Al Rey C. Villagracia; Andres Philip Mayol; Aristotle T. Ubando; Jose Bienvenido Manuel M. Biona; Nelson B. Arboleda; Melanie Y. David; Roy B. Tumlos; Henry Lee; Ong Hui Lin; Rafael A. Espiritu; Alvin B. Culaba; Hideaki Kasai (Clean Technologies and Environmental Policy, 2016)

Nonsteroidal anti-inflammatory drugs, statins, and pancreatic cancer risk: a population-based case–control study - Pik Fang Kho; Jonathan Fawcett; Lin Fritschi; Harvey Risch; Penelope M. Webb; David C. Whiteman; Rachel E. Neale (Cancer Causes & Control, 2016)

Dependency of the Sentinel-1 azimuth wavelength cut-off on significant wave height and wind speed - G. Grieco; W. Lin; M. Migliaccio; F. Nirchio; M. Portabella (International Journal of Remote Sensing, 2016)

Chromogenic media for MRSA diagnostics - Zhenbo Xu; Yuchao Hou; Brian M. Peters; Dingqiang Chen; Bing Li; Lin Li; Mark E. Shirtliff (Molecular Biology Reports, 2016)

A new region-based preparatory factor for landslide susceptibility models: the total flux - C. C. Liu; W. Luo; M. C. Chen; Y. T. Lin; H. L. Wen (Landslides, 2016)

Effects of probiotics on soil microbial activity, biomass and enzymatic activity under cover crops in field and greenhouse studies - Ahsan M. Rajper; Ranjith P. Udawatta; Robert J. Kremer; Chung-ho Lin; Shibu Jose (Agroforestry Systems, 2016)

The agranular and granular insula differentially contribute to gambling-like behavior on a rat slot machine task: effects of inactivation and local infusion of a dopamine D4 agonist on reward expectancy - P. J. Cocker; M. Y. Lin; M. M. Barrus; B. Le Foll; C. A. Winstanley (Psychopharmacology, 2016)

Changes in Sulforaphane and Selenocysteine Methyltransferase Transcript Levels in Broccoli Treated with Sodium Selenite - K. Huang; J. C. Lin; Q. Y. Wu; J. Y. Yan; M. Y. Liu; S. Zhang; W. J. Xiao (Plant Molecular Biology Reporter, 2016)

Changes in Sympathetic Innervation of Rat Caudal Artery in Experimental Myocardial Infarction. Effect of Semax Peptide - A. M. Gorbacheva; A. B. Berdalin; A. N. Stulova; A. D. Nikogosova; M. D. Lin; S. V. Buravkov; S. A. Gavrilova; V. B. Koshelev (Bulletin of Experimental Biology and Medicine, 2016)

Taxonomy of the order Mononegavirales: update 2016 - Claudio L. Afonso; Gaya K. Amarasinghe; Krisztián Bányai; Yīmíng Bào; Christopher F. Basler; Sina Bavari; Nicolás Bejerman; Kim R. Blasdell; François-Xavier Briand; Thomas Briese; Alexander Bukreyev; Charles H. Calisher; et al. (Archives of Virology, 2016)

Examination of Winter Circulation in a Northern Gulf of Mexico Estuary - Jun Lin; Chunyan Li; Kevin M. Boswell; Matthew Kimball; Lawrence Rozas (Estuaries and Coasts, 2016)

Multiplexed Fluid Flow Device to Study Cellular Response to Tunable Shear Stress Gradients - Maggie A. Ostrowski; Eva Y. Huang; Vinay N. Surya; Charlotte Poplawski; Joseph M. Barakat; Gigi L. Lin; Gerald G. Fuller; Alexander R. Dunn (Annals of Biomedical Engineering, 2016)

Early Passage Dependence of Mesenchymal Stem Cell Mechanics Influences Cellular Invasion and Migration - Stephen T. Spagnol; Wei-Chun Lin; Elizabeth A. Booth; Benoit Ladoux; Hillard M. Lazarus; Kris Noel Dahl (Annals of Biomedical Engineering, 2016)

Telomere length change plateaus at 4 years of age in Latino children: associations with baseline length and maternal change - Janet M. Wojcicki; Stephen Shiboski; Melvin B. Heyman; Deena Elwan; Jue Lin; Elizabeth Blackburn; Elissa Epel (Molecular Genetics and Genomics, 2016)

Tropical Storm Kyle (2002) and cold-air damming: their interactions and impacts on heavy rainfall in the Carolinas - Jose M. Garcia-Rivera; Yuh-Lang Lin; Yevgenii Rastigejev (Meteorology and Atmospheric Physics, 2016)

Functional Genomic Analysis of the Impact of Camelina (Camelina sativa) Meal on Atlantic Salmon (Salmo salar) Distal Intestine Gene Expression and Physiology - Tyler D. Brown; Tiago S. Hori; Xi Xue; Chang Lin Ye; Derek M. Anderson; Matthew L. Rise (Marine Biotechnology, 2016)

Peptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro - N. S. Lin’kova; A. O. Drobintseva; O. A. Orlova; E. P. Kuznetsova; V. O. Polyakova; I. M. Kvetnoy; V. Kh. Khavinson (Bulletin of Experimental Biology and Medicine, 2016)

Prevalence of potential nitrogen‐fixing, green sulfur bacteria in the skeleton of reef‐building coral I sopora palifera - Shan‐Hua Yang; Sonny T. M. Lee; Chang‐Rung Huang; Ching‐Hung Tseng; Pei‐Wen Chiang; Chung‐Pin Chen; Hsing‐Ju Chen; Sen‐Lin Tang (Limnology and Oceanography, 2016)
Microbial endoliths, which inhabit interior pores of rocks, skeletons and coral, are ubiquitous in terrestrial and marine environments. In this study, various colored layers stratified the endolithic environment within the skeleton of Isopora palifera ; however, there was a distinct green‐pigmented layer in the skeleton (beneath the living coral tissue). To characterize diversity of endolithic microorganisms, 16S ribosomal RNA gene amplicon pyrosequencing was used to investigate bacterial communities in the green layer of eight I. palifera coral colonies retrieved from two locations on Green Island, Taiwan. The dominant bacterial group in the green layer belonged to the bacterial phylum Chlorobi, green sulfur bacteria capable of anoxygenic photosynthesis and nitrogen fixation. Specifically, bacteria of the genus Prosthecochloris were dominant in this green layer. To our knowledge, this is the first study to provide a detailed profile of endolithic bacteria in coral and to determine the prevalence of Prosthecochloris in the green layer. Based on our findings, we infer that these bacteria may have an important functional role in the coral holobiont in the nutrient‐limited coral reef ecosystem.

Did a Miocene–Pliocene island isolation sequence structure diversification of funnel web spiders in the Taiwan‐Ryukyu Archipelago? - Yong‐Chao Su; Rafe M. Brown; Yung‐Hau Chang; Chung‐Ping Lin; I‐Min Tso (Journal of Biogeography, 2016)
Aim We tested the competing hypotheses concerning the relative importance of Pleistocene versus Miocene–Pliocene geological events for the formation of endemism in an Asian archipelago using the Macrothele taiwanensis (Hexathelidae) species group. Location Taiwan‐Ryukyu Archipelago. Methods We estimated phylogenetic trees from cytochrome oxidase I subunit ( COI ) and 16S rRNA ( 16S ) gene regions and employed Bayesian ancestral range reconstructions to investigate previously debated models of lineage diversification in the Taiwan‐Ryukyu Archipelago. To evaluate alternative geological timeframes for their importance in shaping the genetic structure of funnel web spiders, we used five time calibration schemes to estimate timing of divergence, infer ancestral distributions, and to reconstruct historical demographic changes in each lineage. We tested taxonomic boundaries with two species delimitation procedures. Results Our results indicate a north‐to‐south isolation sequence of the M. taiwanensis group: the Amami lineage diverged first, then Yaeyama, and finally the Taiwanese lineages. Divergence time estimation and population demographic change analyses indicate that Pleistocene climate fluctuations minimally impacted the genetic structure of these spiders. Instead, estimated divergence events correspond to Miocene–Pliocene geological events, strongly supporting a much older timeframe for diversification. The results of species delimitation analyses coincide well with morphological differences observed among the island populations, reinforcing inferred species boundaries, and at least three potential cryptic species were statistically detected within Taiwan. Main conclusions Miocene–Pliocene geological events appear to have contributed disproportionately to diversification in the M. taiwanensis species group. The clear association between geographical area, genetic structure and statistical species delimitation strongly supports an interpretation of allopatric speciation. We advocate comparing our results with those derived from additional study organisms with similar life histories to further explore the Miocene–Pliocene diversification hypothesis.

A remorin gene is implicated in quantitative disease resistance in maize - Tiffany M. Jamann; Xingyu Luo; Laura Morales; Judith M. Kolkman; Chia-Lin Chung; Rebecca J. Nelson (Theoretical and Applied Genetics, 2016)

Sample Management: Recommendation for Best Practices and Harmonization from the Global Bioanalysis Consortium Harmonization Team - Michael J. Redrup; Harue Igarashi; Jay Schaefgen; Jenny Lin; Lisa Geisler; Mohamed Ben M’Barek; Subramanian Ramachandran; Thales Cardoso; Vera Hillewaert (The AAPS Journal, 2016)

Resolving the ancestry of Austronesian-speaking populations - Pedro A. Soares; Jean A. Trejaut; Teresa Rito; Bruno Cavadas; Catherine Hill; Ken Khong Eng; Maru Mormina; Andreia Brandão; Ross M. Fraser; Tse-Yi Wang; Jun-Hun Loo; Christopher Snell; et al. (Human Genetics, 2016)

Validation of self-reported comorbidity status of breast cancer patients with medical records: the California Breast Cancer Survivorship Consortium (CBCSC) - Cheryl Vigen; Marilyn L. Kwan; Esther M. John; Scarlett Lin Gomez; Theresa H. M. Keegan; Yani Lu; Salma Shariff-Marco; Kristine R. Monroe; Allison W. Kurian; Iona Cheng; Bette J. Caan; Valerie S. Lee; et al. (Cancer Causes & Control, 2016)