Highly efficient shrimp shell recovery by solid-state fermentation with Streptomyces sp. SCUT-3 - De-Lin Lu; Ming-Shu Zhang; Jun-Jin Deng; Wen-Jun Lu; Zhen-Dong Yang; Zhi-Wei Li; Yu-Chen Chen; Xiao-Chun Luo (Chemical Engineering Journal, 2023)

From plasma membrane to mitochondria: Time-dependent photodynamic antibacterial and anticancer therapy with a near-infrared AIE-active photosensitizer - Ming-Yu Wu; Zhao-Ju Wu; Qian Zou; Jia-Li Wang; Chuen Kam; Sijie Chen; Shun Feng (Chemical Engineering Journal, 2023)

Superior performances via designed multiple embossments within interfaces for flexible pressure sensors - Yujing Zhang; Yuheng Wang; Chenying Wang; Yifan Zhao; Weixuan Jing; Song Wang; Yaxin Zhang; Xiangyue Xu; Fuzheng Zhang; Kaige Yu; Qi Mao; Qijing Lin; et al. (Chemical Engineering Journal, 2023)

Impacts of organic loading rate and hydraulic retention time on organics degradation, interspecies interactions and functional traits in thermophilic anaerobic co-digestion of food waste and sewage sludge - Xingxing Zhang; Pengbo Jiao; Ming Zhang; Peng Wu; Yufeng Zhang; Yiwei Wang; Kaiyan Xu; Jiazhou Yu; Liping Ma (Bioresource Technology, 2023)

Environmental determinants of household microbial and allergen levels in the Greater Taipei Area - Yohane V.A. Phiri; Meei-Maan Wu; Yi-Hua Chen; Ming-Lun Zou; Chuen-Bin Jiang; Chih-Da Wu; Hsiao-Chun Huang; Shih-Chun Candice Lung; Ling-Chu Chien; Yu-Chun Lo; Fang-Yu Lee; Hsing Jasmine Chao (Building and Environment, 2023)

New (4 → 2)-abeo-clerodane diterpenoids from the Polyalthia laui and their chemotaxonomic significance - Zhang-Xin Yu; Xin-Ming Song; Mu-Yuan Li; Man-Man Zhang; Li-Zhu Huang; Xiao-Bao Li (Biochemical Systematics and Ecology, 2023)

Source-specific health risk analysis on atmospheric hazardous volatile organic compounds (HVOCs) in Nanjing, East China - Yu-Chi Lin; Zi-Jin Zhang; Meng-Yao Cao; Mei-Yi Fan; Ahsan Mozaffar; Ming-Yuan Yu; Feng Xie; Yan-Lin Zhang (Atmospheric Environment, 2023)

Different roles of primary and secondary sources in reducing PM2.5: Insights from molecular markers in Pearl River Delta, South China - Kong Yang; Duo-Hong Chen; Xiang Ding; Jun Li; Yu-Qing Zhang; Tao Zhang; Qiao-Yun Wang; Jun-Qi Wang; Qian Cheng; Hao Jiang; Ping Liu; Zi-Rui Wang; et al. (Atmospheric Environment, 2023)

Somatostatin-Positive Neurons in the Rostral Zona Incerta Modulate Innate Fear-Induced Defensive Response in Mice - Shan Lin; Meng-Yue Zhu; Meng-Yu Tang; Mi Wang; Xiao-Dan Yu; Yi Zhu; Shi-Ze Xie; Dan Yang; Jiadong Chen; Xiao-Ming Li (Neuroscience Bulletin, 2023)
Defensive behaviors induced by innate fear or Pavlovian fear conditioning are crucial for animals to avoid threats and ensure survival. The zona incerta (ZI) has been demonstrated to play important roles in fear learning and fear memory, as well as modulating auditory-induced innate defensive behavior. However, whether the neuronal subtypes in the ZI and specific circuits can mediate the innate fear response is largely unknown. Here, we found that somatostatin (SST)-positive neurons in the rostral ZI of mice were activated by a visual innate fear stimulus. Optogenetic inhibition of SST-positive neurons in the rostral ZI resulted in reduced flight responses to an overhead looming stimulus. Optogenetic activation of SST-positive neurons in the rostral ZI induced fear-like defensive behavior including increased immobility and bradycardia. In addition, we demonstrated that manipulation of the GABAergic projections from SST-positive neurons in the rostral ZI to the downstream nucleus reuniens (Re) mediated fear-like defensive behavior. Retrograde trans-synaptic tracing also revealed looming stimulus-activated neurons in the superior colliculus (SC) that projected to the Re-projecting SST-positive neurons in the rostral ZI (SC-ZIr SST -Re pathway). Together, our study elucidates the function of SST-positive neurons in the rostral ZI and the SC-ZIr SST -Re tri-synaptic circuit in mediating the innate fear response.

Elevated Levels of Naturally-Occurring Autoantibodies Against the Extracellular Domain of p75NTR Aggravate the Pathology of Alzheimer’s Disease - Chen-Yang He; Ding-Yuan Tian; Si-Han Chen; Wang-Sheng Jin; Yuan Cheng; Jia-Yan Xin; Wei-Wei Li; Gui-Hua Zeng; Cheng-Rong Tan; Jie-Ming Jian; Dong-Yu Fan; Jun-Rong Ren; et al. (Neuroscience Bulletin, 2023)

Aerobic degradation of bisphenol A by Pseudomonas sp. LM-1: characteristic and pathway - Chen Gu; Jinxuan Liang; Ming Liu; Jianliang Rui; Jiyan Shi; Yanming Yu; Xuwang Zhang (Biodegradation, 2023)

The onset process of the 2018/2019 Indonesian–Australian summer monsoon: The importance of the air–sea interaction - Yongliang Duan; Hongwei Liu; Ming Feng; Xiangzhou Song; Kuiping Li; Lin Liu; Baochao Liu; Guang Yang; Weidong Yu (Frontiers in Marine Science, 2023)
The Madden–Julian oscillation (MJO) and its associated air–sea interactions during the onset process of the 2018/2019 Indonesian–Australian summer monsoon (IASM) are investigated based on the in situ data from a moored buoy off the coast of northwest Australia, along with ERA5 reanalysis and satellite data. The results verify that the IASM onset in mid-December 2018 was triggered by the first-branch eastward-propagating MJO (FEMJO) originating from the tropical Indian Ocean. However, the strong negative SST anomaly (SSTA) was evident off northwest Australia, which weakens FEMJO over northern Australia and shifts the convective center further northward. The mixed layer heat budget analysis based on the buoy observations reveals that the increased latent heat loss that occurred before the arrival of the FEMJO convection was primarily attributed to the large air–sea temperature difference and strong winds, resulting in the pronounced SSTA.

EMX2OS targeting IGF2BP1 represses Wilms’ tumour stemness, epithelial–mesenchymal transition and metastasis - Hong-Mei Zhang; Ming-Yu Cui; Zhi-Hong Chen (Journal of Genetics, 2023)

Bioactive icetexane and abietane diterpenes from Isodon phyllopodus - Rui Deng; Juan Zou; Chen-Liang Zhao; Ye-Meng Yang; Chuen Fai Ku; Yu Zhu; Zheng-Ming Liang; Jiang-Hai Ye; Lu-Tai Pan; Hong-Jie Zhang (Natural Product Research, 2023)

Stability assessment of soil-nailed slopes using the homogenisation approach - Chen Guang-Hui; Zou Jin-Feng; Sheng Yu-Ming; Chen Jing-Yu (European Journal of Environmental and Civil Engineering, 2023)

Development of an interpretable machine learning model associated with heavy metals’ exposure to identify coronary heart disease among US adults via SHAP: Findings of the US NHANES from 2003 to 2018 - Xi Li; Yang Zhao; Dongdong Zhang; Lei Kuang; Hao Huang; Weiling Chen; Xueru Fu; Yuying Wu; Tianze Li; Jinli Zhang; Lijun Yuan; Huifang Hu; et al. (Chemosphere, 2023)

Oriented bio-feeding control of the anaerobic biodegradation of ethinyl estradiol - Jinyi Qin; Jiao Fang; Fei Gao; Yiwen He; Ming Su; Yu Zhang; Min Yang (Chemosphere, 2023)

Bioremediation potential of cadmium by recombinant Escherichia coli surface expressing metallothionein MTT5 from Tetrahymena thermophila - Che-Wei Lu; Hsin-Cheng Ho; Chao-Ling Yao; Tsung-Yu Tseng; Chih-Ming Kao; Ssu-Ching Chen (Chemosphere, 2023)

Influence of aged and pristine polyethylene microplastics on bioavailability of three heavy metals in soil: Toxic effects to earthworms (Eisenia fetida) - Ming Li; Hao Jia; Qingchuan Gao; Song Han; Yong Yu; Long Sun (Chemosphere, 2023)

A novel method based on solid phase extraction and liquid chromatography-tandem mass spectrometry warrants occurrence of trace xanthates in water - Yu-Ting Qiao; Ying-Xin Lu; Peng-Fei Yu; Nai-Xian Feng; Yan-Wen Li; Hai-Ming Zhao; Quan-Ying Cai; Lei Xiang; Ce-Hui Mo; Qing X. Li (Chemosphere, 2023)

Dietary supplementation of yeast mannan enhances antiviral immunity of zebrafish (Danio rerio) - Hui Liang; Yadong Xie; Yu Li; Mingxu Xie; Ming Li; Wei Zhou; Jie Chen; Zhen Zhang; Yalin Yang; Chao Ran; Zhigang Zhou (Aquaculture, 2023)

Comparative analysis of growth performance, pharyngeal teeth and intestinal traits in F1 hybrids of female Megalobrama amblycephala × male Culter mongolicus - Fangzhou Hu; Haitao Zhong; Pengfei Yu; Jingjing Fan; Chang Wu; Shi Wang; Dingbin Gong; Yu Sun; Xin Gao; Ming Wen; Chenchen Tang; Min Tao; et al. (Aquaculture, 2023)

The effect of nitrite and nitrate treatment on growth performance, nutritional composition and flavor-associated metabolites of grass carp (Ctenopharyngodon idella) - Jun-Ming Zhang; Bing Fu; Yi-chao Li; Jin-Hui Sun; Jun Xie; Guang-Jun Wang; Jing-Jing Tian; Gen Kaneko; Er-Meng Yu (Aquaculture, 2023)

Triptolide exposure induces oxidative stress and decreases oocyte quality in mouse - Qian-Qian Hao; Zhi-Ran Xu; Han Nie; Feng-Xin Qiao; Ming-Xin Sun; Yue-Cen Liu; Hai-Long Wang; Zhong-Quan Qi; Chang-Long Xu; Yu Liu (Toxicon, 2023)

Naïve-like conversion of bovine induced pluripotent stem cells from Sertoli cells - Yu Jiang; Ning-Ning Cai; Xing-Lan An; Wen-Qian Zhu; Rui Yang; Bo Tang; Zi-Yi Li; Xue-Ming Zhang (Theriogenology, 2023)

Selection of optimal seismic intensity measures using fuzzy-probabilistic seismic demand analysis and fuzzy multi-criteria decision approach - Ming-Yang Xu; Da-Gang Lu; Xiao-Hui Yu; Ming-Ming Jia (Soil Dynamics and Earthquake Engineering, 2023)

Pore reconstruction mechanism of wheat straw-templated Li4SiO4 pellets for CO2 capture - Yingchao Hu; Hongyuan Lu; Zhe Lv; Ming Zhang; Ge Yu (Science of The Total Environment, 2023)

Technological development pathway for carbon neutrality in China - Siyue Guo; Yu Liu; Weichen Zhao; Jiaquan Li; Guangwen Hu; Hui Kong; Yifan Gu; Bang Xu; Xiaodan Huang; Yan Zheng; Shihan Zhang; Da Zhang; et al. (Science Bulletin, 2023)

Release of microplastics from disposable cups in daily use - Huier Chen; Liheng Xu; Kuai Yu; Fang Wei; Ming Zhang (Science of The Total Environment, 2023)

A repeated dose 28-day oral toxicity study of sodium dehydroacetate (DHA-S) in Wistar rats - Hong-ju Du; Guo-hui Tong; Jun-yu Ning; Shan Gao; Qing Yang; Ying Feng; Peng Zhang; Wei Zhang; Hai-ming Jing; Guo-jun Li (Regulatory Toxicology and Pharmacology, 2023)

Variations in Asian summer monsoon and hydroclimate during Heinrich stadials 4 revealed by stalagmite stable isotopes and trace elements - Yao Wu; Ting-Yong Li; Jun-Yun Li; Hai Cheng; You-Feng Ning; Chuan-Chou Shen; Yan Yang; Jing-Yao Zhao; Chao-Jun Chen; Ming-Qiang Liang; Si-Ya Xiao; Hai-Ying Qiu; et al. (Quaternary Science Reviews, 2023)

Detection of flufenamic acid based on affordable inorganic SrFe2O4 nanorods decorated sulfur atoms substituted graphitic carbon nitride nanocomposite - Vinitha Mariyappan; Naveen Karuppusamy; Tse-Wei Chen; Shen-Ming Chen; Joefranklin Jesuraj; Muthumariappan Akilarasan; Bih-Show Lou; Jaysan Yu (Process Safety and Environmental Protection, 2023)

Bioactive diterpenoids and sesquiterpenoids with different skeletons from Salvia digitaloides Diels - Xu Liu; Xiao-Qing Zhan; Mei-Jie Wang; Wen-Bo Cui; Xiao-Han Chen; Feng-Ming Qi; Jian-Ning Yu; Jian-Ye Dai; Dong-Qing Fei; Zhan-Xin Zhang (Phytochemistry, 2023)

The depth-keeping performance of autonomous underwater vehicle advancing in waves integrating the diving control system with the adaptive fuzzy controller - Yu-Hsien Lin; Chao-Ming Yu; I-Chen Wu; Chia-Yu Wu (Ocean Engineering, 2023)

Experimental study on the distribution law of the blade foot resistance of a large deep-water open caisson in sand - Bing-nan Jiang; Ting Yu; Wen-ming Peng; Ying-bin Zhang; Shun-bin He; Jian-lin Ma (Ocean Engineering, 2023)

Review on recent progress in on-line monitoring technology for atmospheric pollution source emissions in China - Huanqin Wang; Jitong Zhou; Xue Li; Qiang Ling; Hongyuan Wei; Lei Gao; Ying He; Ming Zhu; Xiao Xiao; Youjiang Liu; Shan Li; Chilai Chen; et al. (Journal of Environmental Sciences, 2023)

Compilation of reaction kinetics parameters determined in the Key Development Project for Air Pollution Formation Mechanism and Control Technologies in China - Yu Liu; Ming Zhou; Keding Lu (Journal of Environmental Sciences, 2023)

Antibacterial performance of electrodeposited Cu@Cu2O coatings on concrete using printed circuit board wastewater - Zhengyu Zhu; Hongqiang Chu; Ming-Zhi Guo; Youxu Zeng; Xuanlin Li; Xiaoyu Yu; Haonan Xiao; Pengfei Wang (Journal of Cleaner Production, 2023)

An investigation into the effect of water injection parameters on synergetic mining of geothermal energy in mines - Yu Xu; Zijun Li; Ming Tao; Saeid Jalilinasrabady; Junjian Wang; Gang Li; Kaiqi Zhong (Journal of Cleaner Production, 2023)

Early Paleozoic collision-related structures in the Tarim Craton, NW China: Implications for the Proto-Tethys evolution - Yue-Jun Li; Yong-Jin Gao; Hui Zhou; Guang-Ya Zhang; Lei Wen; Yan Zhao; Cheng Li; Duo-Ming Zheng; Ya-Lei Liu; Hong-Hui Li; Cai-Ming Luo; Tong-Fei Huang; et al. (Journal of Asian Earth Sciences, 2023)

Geochemistry of lacustrine carbonate rocks in southwestern Qaidam: Implications of silicate weathering and carbon burial triggered by the uplift of the Tibetan Plateau - Shengyin Zhang; Ming Shao; Tao Wang; Yu Pei; Bo Chen (International Journal of Coal Geology, 2023)

Molting-related proteases in the brown planthopper, Nilaparvata lugens - Yu-Cheng Xie; Hou-Hong Zhang; Han-Jing Li; Xiao-Ya Zhang; Xu-Mei Luo; Ming-Xing Jiang; Chuan-Xi Zhang (Insect Biochemistry and Molecular Biology, 2023)

Marked shifts of harmful algal blooms in the Bohai Sea linked with combined impacts of environmental changes - Xiao-Yu Li; Ren-Cheng Yu; Anthony J. Richardson; Chaojiao Sun; Ruth Eriksen; Fan-Zhou Kong; Zheng-Xi Zhou; Hui-Xia Geng; Qing-Chun Zhang; Ming-Jiang Zhou (Harmful Algae, 2023)

Precipitation/dissolution equilibrium to achieve trace iron doping on the surface of β-Ni(OH)2 for electrocatalytic oxygen evolution - Hui-Ying Zhao; Ruo-Yao Fan; Zi-Yi Zhao; Xin-Yu Zhang; Bin Dong; Qian-Xi Lv; Xin Liu; Bin Liu; Yong-Ming Chai (Fuel, 2023)

Enhanced sorption of carbonyl groups by zirconium hydroxide modified with polydopamine for highly selective production of alcohols via MPV reduction under mild conditions - Lei Ye; Yiwen Han; Ming Zhang; Zhihao Yu; Xuebin Lu (Fuel, 2023)

Region, vintage, and grape maturity co-shaped the ionomic signatures of the Cabernet Sauvignon wines - Xiao Han; Hao-Cheng Lu; Yu Wang; Xiao-Tong Gao; Hui-Qing Li; Meng-Bo Tian; Ning Shi; Ming-Yu Li; Xiao-Li Yang; Fei He; Chang-Qing Duan; Jun Wang (Food Research International, 2023)

Transcriptome and metabolome reveal the effects of three canopy types on the flavonoids and phenolic acids in ‘Merlot’ (Vitis vinifera L.) berry pericarp - Shou-An Han; Hui Xie; Min Wang; Jun-Gao Zhang; Yu-Hui Xu; Xue-Hui Zhu; Aiermaike Caikasimu; Xue-Wei Zhou; Si-Le Mai; Ming-Qi Pan; Wen Zhang (Food Research International, 2023)

Enhanced stability and combustion performance of AlH3 in combination with commonly used oxidizers - Ming-Hui Yu; Su-Lan Yang; Wu-Xi Xie; Zhao-Yang Zhu; He-Ping Li; Qi-Long Yan (Fuel, 2023)

Mice kidney biometabolic process analysis after cantharidin exposure using widely-targeted metabolomics combined with network pharmacology - Tianmu He; Lijuan Xiong; Yixin Zhang; Rong Yan; Ming Yu; Meichen Liu; Liu Liu; Cancan Duan; Xiaofei Li; Jianyong Zhang (Food and Chemical Toxicology, 2023)

3-MCPD exposure enhances ovarian fibrosis and reduces oocyte quality in mice - Quan-Kuo He; Yan-Ping Li; Zhi-Ran Xu; Wen-Bo Wei; Feng-Xin Qiao; Ming-Xin Sun; Yue-Cen Liu; Yan-Zhu Chen; Hai-Long Wang; Zhong-Quan Qi; Yu Liu (Environmental Pollution, 2023)

Exploring plant growth promoting rhizobacteria potential for green agriculture system to optimize sweet potato productivity and soil sustainability in northern Jiangsu, China - Yi-Yang Yu; Jing-Da Xu; Mei-Zhen Gao; Tao-Xiang Huang; Ying Zheng; Yi-Yuan Zhang; Yun-Peng Wang; Yu-Ming Luo; Ying Zhang; Yong-Hong Hu; Jian-Hua Guo; Chun-Hao Jiang (European Journal of Agronomy, 2023)

Fetal exposure to organic contaminants revealed by infant hair: A preliminary study in south China - Feng-Shan Cai; Bin Tang; Jing Zheng; Xiao Yan; Wei-Keng Luo; Mian He; Xiao-Jun Luo; Ming-Zhong Ren; Yun-Jiang Yu; Bi-Xian Mai (Environmental Pollution, 2023)

Novel meter-scale seismic metamaterial with low-frequency wide bandgap for Lamb waves - Yu Ming Luo; Ting Ting Huang; Yi Zhang; Hang Hang Xu; Yi Min Xie; Xin Ren (Engineering Structures, 2023)

Quantification of electron transfer on carbon nanotubes: Effect of edge defects on electro-oxidation of glycerol catalyzed by platinum - Jingyan Ming; Hongquan Fu; Guangxing Yang; Hongjuan Wang; Jiangnan Huang; Feng Peng; Yonghai Cao; Hao Yu (Chemical Engineering Journal, 2023)

Identifying the impact of Fe nanoparticles encapsulated by nitrogen-doped carbon to Fe single atom sites for boosting oxygen reduction reaction toward Zn-air batteries - Wen-Jun Niu; Ying-Yun Yan; Ru-Ji Li; Wei-Wei Zhao; Jiang-Lei Chen; Ming-Jin Liu; Bingni Gu; Wen-Wu Liu; Yu-Lun Chueh (Chemical Engineering Journal, 2023)

Pre-removing partial ammonium ions from the interlayer of ammonium vanadate with acid treating for quasi-solid-state flexible zinc ion batteries - Liming Chen; Haifeng Yue; Ziqiang Zhang; Yu Ma; Yuanming Wang; Ming Xu; Youyuan Huang; Guohui Yuan (Chemical Engineering Journal, 2023)

High-performance flame-retardant aliphatic polyamide via enhanced chain entanglement - Min Jiang; Bo-Wen Liu; Feng-Ming He; Qin Zhang; Ao Wang; De-Ming Guo; Hai-Bo Zhao; Li Chen; Yu-Zhong Wang (Chemical Engineering Journal, 2023)

An approach to the high efficient exploitation of nature gas hydrate and carbon sequestration via injecting CO2/H2 gas mixture with varying composition - Bo-Jian Cao; Yi-Fei Sun; Hong-Nan Chen; Jin-Rong Zhong; Ming-Long Wang; Meng-Ya Niu; Jing-Yu Kan; Chang-Yu Sun; Dao-Yi Chen; Guang-Jin Chen (Chemical Engineering Journal, 2023)

Multifunctional lysosome-targetable fluorescent probe for imaging peroxynitrite in acute liver injury model - Kai Wang; Rui Guo; Xu-Yang Chen; Yu-Shun Yang; Lu-Qin Qiao; Ming-Lin Wang (Chemical Engineering Journal, 2023)

Anion-exchange assisted sequential deposition for stable and efficient FAPbI3-based perovskite solar cells - Xinning Jiao; Wei-Min Gu; Yanting Xu; Ke-Jian Jiang; Guanghui Yu; Qing-Wu Zhang; Cai-Yan Gao; Cai-Ming Liu; Xin-Heng Fan; Lian-Ming Yang; Yanlin Song (Chemical Engineering Journal, 2023)

Cationic molecular probes based on aggregation-induced emission for fluorescent sensing and super-resolution imaging of insulin fibrosis - Li-Jun Mei; Cheng Fan; Chu-Ran Xu; Qi Yu; Chong Li; Ya-Long Wang; Ming-Qiang Zhu (Chemical Engineering Journal, 2023)

Excellent adsorptive-photocatalytic performance of zinc oxide and biomass derived N, O-contained biochar nanocomposites for dyes and antibiotic removal - Shunli Yu; Juan Zhou; Yanmei Ren; Zhiwang Yang; Ming Zhong; Xiaoqiang Feng; Bitao Su; Ziqiang Lei (Chemical Engineering Journal, 2023)

Doping engineering of carrier transporting layers for ambient-air-stable lead-free rudorffite solar cells prepared by thermal-assisted doctor blade coating - Kai-Chi Hsiao; Yen-Fu Yu; Ching-Mei Ho; Meng-Huan Jao; Yu-Hsiang Chang; Shih-Hsuan Chen; Yin-Hsuan Chang; Wei-Fang Su; Kun-Mu Lee; Ming-Chung Wu (Chemical Engineering Journal, 2023)

Effect of feeding gas type and nitrogen: Sulfur ratio on a novel sulfide-driven denitrification methane oxidation (SDMO) system - Wei Wang; Lei Zhao; Miao Yu; Tian-Ming Yin; Xi-Jun Xu; Duu-Jong Lee; Nan-Qi Ren; Chuan Chen (Chemical Engineering Journal, 2023)

Amyloid-like coatings decorated electrodes boost the uranium electro-adsorption from seawater - Hao Ye; Tian-Hao Li; Yu-Qi Huang; Jia-Min Jin; Jin-Yan Fei; Ming-Bang Wu; Juming Yao (Chemical Engineering Journal, 2023)

Hierarchical aerogels with hollow Co3O4 nanoparticles and graphitized carbon vesicles embedded in multi-channel carbon nanofibers for high-performance asymmetric supercapacitors - Ming Zhang; Xuejiao Wang; Dongzhi Yang; Tianyu Zhao; Jin Qu; Zhong-Zhen Yu (Chemical Engineering Journal, 2023)

Neural Mechanism Underlying Task-Specific Enhancement of Motor Learning by Concurrent Transcranial Direct Current Stimulation - Ying Wang; Jixian Wang; Qing-Fang Zhang; Ke-Wei Xiao; Liang Wang; Qing-Ping Yu; Qing Xie; Mu-Ming Poo; Yunqing Wen (Neuroscience Bulletin, 2023)

AICellCounter: A Machine Learning-Based Automated Cell Counting Tool Requiring Only One Image for Training - Junnan Xu; Andong Wang; Yunfeng Wang; Jingting Li; Ruxia Xu; Hao Shi; Xiaowen Li; Yu Liang; Jianming Yang; Tian-Ming Gao (Neuroscience Bulletin, 2023)

Correction to: Ketone Body Rescued Seizure Behavior of LRP1 Deficiency in Drosophila by Modulating Glutamate Transport - Jin-Ming Zhang; Ming-Jie Chen; Jiong-Hui He; Ya-Ping Li; Zhi-Cai Li; Zi-Jing Ye; Yong-Hui Bao; Bing-Jun Huang; Wen-Jie Zhang; Ping Kwan; Yu-Ling Mao; Jing-da Qiao (Journal of Molecular Neuroscience, 2023)

Retraction Note: Knockdown of long non‑coding RNA TUG1 depresses apoptosis of hippocampal neurons in Alzheimer’s disease by elevating microRNA‑15a and repressing ROCK1 expression - Xia Li; Sheng‑Wu Wang; Xi‑Ling LI; Feng‑Yuan Yu; Hai‑Ming Cong (Inflammation Research, 2023)

Occurrence, correlation, and partitioning of organophosphate esters in soil and tree bark from a megacity, Western China - Can Wang; Rui-Yu Yuan; Shi-Qiang Wei; Ming-Jing He (Environmental Science and Pollution Research, 2023)

Brevibacillus daliensis sp. nov., Isolated From Soil in Machangqing Nature Reserve - Shi-Qiang Ye; Jiang-Yuan Zhao; Le-Le Li; Cheng Ling; Meng-Yu Zhang; Jing Tang; Song-Guo Liang; Jian-Yu Li; Pei-Wen Yang; Jiao Xiong; Lu-Yao Feng; Zhu-Feng Shi; et al. (Current Microbiology, 2023)

Water-in-zircon: a discriminant between S- and I-type granitoid - Jing Mo; Xiao-Ping Xia; Peng-Fei Li; Christopher J. Spencer; Chun-Kit Lai; Jian Xu; Qing Yang; Ming-Dao Sun; Yang Yu; Luke Milan (Contributions to Mineralogy and Petrology, 2023)

Correction to: A new method to determine the segmentation of pore structure and permeability prediction of loess based on fractal analysis - Tuo Lu; Ya‑ming Tang; Hong‑yu Ren; Yong‑bo Tie (Bulletin of Engineering Geology and the Environment, 2023)

Disordered Expression of Tight Junction Proteins Is Involved in the Mo-induced Intestinal Microenvironment Dysbiosis in Sheep - Chen-yu Zhang; Jing Zhao; Ming-xian Mao; Zhan-qin Zhao; Feng-jun Liu; Hong-wei Wang (Biological Trace Element Research, 2023)

Zinc supplementation ameliorates sorafenib-induced cognitive impairment through ROS/JNK signaling pathway - Can-Can Zhou; Yu-Qiong He; Yu-Shuang Qiu; Chen-Xu Ni; Fu-Ming Shen; Dong-Jie Li (Biological Trace Element Research, 2023)

Defect inspection of indoor components in buildings using deep learning object detection and augmented reality - Shun-Hsiang Hsu; Ho-Tin Hung; Yu-Qi Lin; Chia-Ming Chang (Earthquake Engineering and Engineering Vibration, 2023)

Effects of nitrogen fertilizer on soil microbial residues and their contribution to soil organic carbon and total nitrogen in a rice-wheat system - Quanyi Hu; Tianqi Liu; Huina Ding; Chengfang Li; Wenfeng Tan; Ming Yu; Juan Liu; Cougui Cao (Applied Soil Ecology, 2023)

Cultivation of Haematococcus pluvialis in source-separated urine for biomass production and astaxanthin accumulation - Guan-qiu Ma; Li-hua Li; Yu Hong; Ming-ran Yu (Algal Research, 2023)

Bacillus predominates in the Ophiocordyceps pseudolloydii-infected ants, and it potentially improves protection and utilization of the host cadavers - Hao-Yu Kuo; Ming-Chung Chiu; Jui-Yu Chou (Archives of Microbiology, 2023)
The bacterial communities that colonize the cadaver environment of insects infected and killed by parasitic fungi can be selected by the sympatric fungi and provide novel impacts. In this study, we found that Bacillus cereus/thuringiensis predominate the bacterial community in Dolichoderus thoracicus ant cadavers colonized by O. pseudolloydii . The most predominant bacterial strains in these ant cadavers were hemolytic and able to produce hydrolytic enzymes for digesting the ant tissue. A relatively intense lethal effect on the co-cultured nematode was displayed by a hemolytic strain. Moreover, the antagonistic effect against pathogenic fungi detected in the bacteria sympatric with O. pseudolloydii was reported here. Naphthoquinones have been shown to confer antibacterial activities and produced by the ant-pathogenic Ophiocordyceps fungi. However, our results did not show the naphthoquinone tolerance we expected to be detected in the bacteria from the ant infected by O. pseudolloydii . The bacterial diversity in the samples associated with O. pseudolloydii infected ants as revealed in this study will be a step forward to the understanding of the roles playing by the microbial community in the native habitats of O. pseudolloydii .

Dynamical systems persistence parameter of sea surface temperature and its associations with regional averaged index over the tropical Pacific - Ming Shi; Yu Huang; Zuntao Fu (International Journal of Climatology, 2022)
Due to an index defined from regionally averaged sea surface temperature anomalies (SSTAs) unable to adequately characterize SSTA events, the dynamical persistence parameter was employed to infer more information than what the averaged SSTA index (SI) can capture from a new respect. By taking the whole SSTA field over a specific region as a dynamical system, was calculated to infer more (such as SSTA gradient) than SI. Moreover, the values of can provide the persistence information, low for long‐lasting SSTA events with well‐defined spatial patterns and high for transient behaviours. Globally, and SI can be taken as approximately orthogonal, but locally there are distinct associations between them. Detailed studies found that there are three kinds of origins for this global independence: alternating strong negative and positive correlation during extreme events, independence under the neutral conditions and low correlation caused by the inability of SI to the marked SSTA gradient. All above findings improve the understanding on the physical indications of and indicate that the new metric is at least a good supplement to the SSTA indices based on the regional average.

Trifolium repens and biochar addition affecting soil nutrients and bacteria community - Pingnan Zhao; Jie Yu; Xiaoyuan Zhang; Zhixing Ren; Ming Li; Song Han (Environmental Science and Pollution Research, 2022)

Associations between residential proximity to agricultural land use as pesticides exposure and birth outcomes - Kuna-Chun Chen; Shuo-Fang Lee; Shyang-Woei Lin; Jia-Shan Xie; Yu‐Hsun Chang; Lih-Ming Yiin; Chia-Jung Hsieh (Environmental Science and Pollution Research, 2022)

UHPLC-QTOF-MS/MS based characterization of anti-tumor constituents in Ceratocarpus arenarius L. and identification of EGFR-TK inhibitors by virtual screening - Le Pan; Li Li; Lu Xu; Jiaojiao Zhang; Jiashan Li; Ming Gao; JinMen Yu; Lu Jin; Dongyu Lei (Natural Product Research, 2022)

MdbHLH51 plays a positive role in anthocyanin accumulation in ‘Red Delicious’ apples - Gai-Xing Ning; Wen-Fang Li; Ming-Yu Chu; Zong-Huan Ma; Ping Wang; Juan Mao; Bai-Hong Chen (Trees, 2022)

Mesenchymal Stem Cell Secreted-Extracellular Vesicles are Involved in Chondrocyte Production and Reduce Adipogenesis during Stem Cell Differentiation - Yu-Chen Tsai; Tai-Shan Cheng; Hsiu-Jung Liao; Ming-Hsi Chuang; Hui-Ting Chen; Chun-Hung Chen; Kai-Ling Zhang; Chih-Hung Chang; Po-Cheng Lin; Chi-Ying F. Huang (Tissue Engineering and Regenerative Medicine, 2022)
Background: Extracellular vesicles (EVs) are derived from internal cellular compartments, and have potential as a diagnostic and therapeutic tool in degenerative disease associated with aging. Mesenchymal stem cells (MSCs) have become a promising tool for functional EVs production. This study investigated the efficacy of EVs and its effect on differentiation capacity. Methods: The characteristics of MSCs were evaluated by flow cytometry and stem cell differentiation analysis, and a production mode of functional EVs was scaled from MSCs. The concentration and size of EVs were quantitated by Nanoparticle Tracking Analysis (NTA). Western blot analysis was used to assess the protein expression of exosome-specific markers. The effects of MSC-derived EVs were assessed by chondrogenic and adipogenic differentiation analyses and histological observation. Results: The range of the particle size of adipose-derived stem cells (ADSCs)- and Wharton’s jelly -MSCs-derived EVs were from 130 to 150 nm as measured by NTA, which showed positive expression of exosomal markers. The chondrogenic induction ability was weakened in the absence of EVs in vitro . Interestingly, after EV administration, type II collagen, a major component in the cartilage extracellular matrix, was upregulated compared to the EV-free condition. Moreover, EVs decreased the lipid accumulation rate during adipogenic induction. Conclusion: The results indicated that the production model could facilitate production of effective EVs and further demonstrated the role of MSC-derived EVs in cell differentiation. MSC-derived EVs could be successfully used in cell-free therapy to guide chondrogenic differentiation of ADSC for future clinical applications in cartilage regeneration.

Rapid antidepressant-like effects of muscarinic receptor antagonists require BDNF-dependent signaling in the ventrolateral periaqueductal gray - Hung-Wei Kan; Wei-Hao Peng; Cheng-Chun Wu; Deng-Wu Wang; Ming Tatt Lee; Yung-Kuo Lee; Tian-Huei Chu; Yu-Cheng Ho (Psychopharmacology, 2022)

OECs Prevented Neuronal Cells from Apoptosis Partially Through Exosome-derived BDNF - Zhe Chen; Hong Fan; Zi-Yi Chen; Chao Jiang; Ming-Zhe Feng; Xin-Yu Guo; Hao Yang; Ding-Jun Hao (Journal of Molecular Neuroscience, 2022)

AIoT-Based Ergometer for Physical Training in Frail Elderly with Cognitive Decline: A Pilot Randomized Control Trial - Chih-Chun Lin; Li-Chieh Kuo; Yu-Sheng Lin; Chia-Ming Chang; Fang Wen Hu; Yi-Jing Chen; Chun-Tse Lin; Fong-Chin Su (Journal of Medical and Biological Engineering, 2022)
Purpose Reduced physical activity is reported in the elderly, especially in institutional residents. Institutionalized older adults exhibit a high prevalence of frailty. In this work, we developed an artificial intelligence of things (AIoT)-based feedback assistive strengthening ergometer (AIFASE), for the physical strengthening of the elderly with intelligent assistance. Methods We conducted a 12-week intervention in a long-term care facility. In total, 16 participants (84.38 ± 6.0 years; 4 males and 12 females) were recruited with 1:1 randomization of exercise to control groups. The muscle strength of the lower extremities, timed up and go test (TUG), and Short-form Physical Performance Battery (SPPB) of the participants were measured. The AIFASE system allows the clinical staff to record the personal physical performance of the elderly and generates personalized exercise prescriptions accordingly. AIFASE also displays the current usage status of all ergometers and the users’ physiological conditions. The algorithms were developed to generate warning alerts when the training workload was too large by personal physiological detection. AIFASE automatically customized the exercise prescription according to the user’s exercise performance. Results After a 12-week AIFASE intervention, the intervention group exhibited significant improvements in the strength of the hip flexor, Semi-Tandem Stand, and Tandem Stand. Conclusion In this study, we developed an AIoT ergometer that delivered customized physical training prescriptions to improve the physical performance of long-term care facility residents. We believe that the application of AIFASE will help improve the quality of institutional care.

Diversity of endophytic fungi in Coptis chinensis Franch. and their activity against methicillin-resistant Staphylococcus aureus - Qianliang Ming; Xiuning Huang; Linming Guo; Dong Liu; Lingyue Qin; Yimo He; Yu Tang; Yanxia Liu; Junkang Liu; Peng Li (Folia Microbiologica, 2022)

Recognizing and managing construction land reduction barriers for sustainable land use in China - Jia-He Zhou; Yu-Ming Zhu; Lei He; Hao-Jing Song; Bing-Xu Mu; Fen Lyu (Environment, Development and Sustainability, 2022)

A new method to determine the segmentation of pore structure and permeability prediction of loess based on fractal analysis - Tuo Lu; Ya-ming Tang; Hong-yu Ren; Yong-bo Tie (Bulletin of Engineering Geology and the Environment, 2022)

An hourly shallow landslide warning model developed by combining automatic landslide spatial susceptibility and temporal rainfall threshold predictions - Yi-ming Cao; Wei Guo; Yu-ming Wu; Lang-ping Li; Yi-xing Zhang; Heng-xing Lan (Journal of Mountain Science, 2022)

Consequences and Mechanisms of Left Atrium Remodeling in Aging Rabbits - Teng Wang; Yan Huang; Zi-Ming Wang; Yu-Ting Chen; Hong Cao; Tao Liu; Qiang Zou (Bulletin of Experimental Biology and Medicine, 2022)

Immunogenicity and protective efficacy of a DNA vaccine inducing optimal expression of the SARS-CoV-2 S gene in hACE2 mice - Zhuo-xin Li; Sheng Feng; He Zhang; Xin-yu Zhuang; Chao Shang; Shi-yu Sun; Ji-cheng Han; Yu-biao Xie; Jin-yong Zhang; Wei Wang; Cheng-hui Li; Guan-yu Zhao; et al. (Archives of Virology, 2022)

CYP35 family in Caenorhabditis elegans biological processes: fatty acid synthesis, xenobiotic metabolism, and stress responses - Sharoen Yu Ming Lim; Mustafa Alshagga; Cin Kong; Mohammed Abdullah Alshawsh; Salah AbdulRazak Alshehade; Yan Pan (Archives of Toxicology, 2022)

Sex-related differences in safety profiles, pharmacokinetics and tissue distribution of sinomenine hydrochloride in rats - Hong Huang; Er-Bing Zhang; Ou-Yang Yi; Han Wu; Guiming Deng; Yu-Ming Huang; Wen-Liang Liu; Jian-Ye Yan; Xiong Cai (Archives of Toxicology, 2022)

Abundant and diverse endophytic bacteria associated with medicinal plant Arctium lappa L. and their potential for host plant growth promoting - Jia-Qi Liu; Shu-Mei Chen; Chun-Mei Zhang; Ming-Jie Xu; Ke Xing; Cheng-Guo Li; Kui Li; Yu-Qin Zhang; Sheng Qin (Antonie van Leeuwenhoek, 2022)

Quantitative characterization of seepage behavior in rough fracture considering hydromechanical coupling effect: an experimental study - Xiang Yu; Tong Zhang; Ke Yang; Fei Yu; Yang Liu; Ming Tang (Acta Geophysica, 2022)

Nitrogen-metabolising microorganism analysis in rapid sand filters from drinking water treatment plant - Qihui Gu; Jun Ma; Jumei Zhang; Weipeng Guo; Huiqing Wu; Ming Sun; Juan Wang; Xianhu Wei; Youxiong Zhang; Montong Chen; Liang Xue; Yu Ding; et al. (Environmental Science and Pollution Research, 2022)

Protective effect of ginsenoside Rd on military aviation noise-induced cochlear hair cell damage in guinea pigs - Xue-min Chen; Yu-hui Liu; Shuai-fei Ji; Xin-miao Xue; Lin-lin Wang; Min Zhang; Yao-ming Chang; Xiao-cheng Wang (Environmental Science and Pollution Research, 2022)

Assessing the impact of rockfall on the retaining structures of a mountain road: a case study in Taiwan - Che-Ming Yang; Chung-Hsun Lee; Chun-Yuan Liu; Wei-Kai Huang; Meng-Chia Weng; Yu-Yao Fu (Landslides, 2022)

Mechanism and efficiency research of P- and N-codoped graphene for enhanced paracetamol electrocatalytic degradation - Qian Zhang; Yong-bo Yu; Jun-ming Hong (Environmental Science and Pollution Research, 2022)

Relationship between meteorological factors and mortality from respiratory diseases in a subtropical humid region along the Yangtze River in China - Lingxiang Yu; Junjun Zhu; Ming Shao; Jinian Wang; Yubo Ma; Kai Hou; Huijun Li; Jiansheng Zhu; Xiaoyun Fan; Faming Pan (Environmental Science and Pollution Research, 2022)

Genistein Alleviates Oxidative Stress and Inflammation in the Hypothalamic Paraventricular Nucleus by Activating the Sirt1/Nrf2 Pathway in High Salt-Induced Hypertension - Li-Gang Niu; Na Sun; Kai-Li Liu; Qing Su; Jie Qi; Li-Yan Fu; Guo-Rui Xin; Yu-Ming Kang (Cardiovascular Toxicology, 2022)

Genetic variations in the bitter taste receptor gene TAS2R38 are related to cigarette smoking behavior in Han Chinese smokers - Fei-Yan Qi; Zhou-Hai Zhu; Meng Li; Ying Guan; Qi-Yuan Peng; She-Ming Lu; Zhi-Hua Liu; Ming-Feng Wang; Ming-Ming Miao; Zhang-Yu Chen; Xue-Mei Li; Jie Bai; et al. (Genes & Genomics, 2022)

mTORC1/C2 regulate spermatogenesis in Eriocheir sinensis via alterations in the actin filament network and cell junctions - Zhen-Fang Li; Shuang-Li Hao; Lan-Min Wang; Hong-Yu Qi; Jia-Ming Wang; Fu-Qing Tan; Wan-Xi Yang (Cell and Tissue Research, 2022)

Assessing phenovariant species pairs of moray eels: Hybridization, introgression, and morphology - Wen‐Chien Huang; Hong‐Ming Chen; Yung‐Che Tseng; Te‐Yu Liao (Zoologica Scripta, 2022)
Phenovariant is a pair of populations or species with distinct phenotypes but little to no genetic divergence, which may have resulted from strong assortative mating, hybridization, or incomplete lineage sorting that changes in the phenotype have exceeded the genotype. Previous studies had mainly tackled this issue on small, colourful reef fishes, but little effort has been made to the barely seen and solitary taxa like the morays (family Muraenidae). In the present study, three species pairs of sympatric morays from Taiwanese waters revealed as phenovariant in the mitochondrial cytochrome oxidase I ( COI ) were examined from the molecular and morphological perspectives, with three dissimilar scenarios discovered: (1) no hybridization was found between the morphologically most distinct Gymnothorax intesi and Gymnothorax neglectus ; (2) Gymnothorax kidako bidirectionally hybridized with Gymnothorax prionodon instead of its closely related species Gymnothorax pseudokidako ; and (3) frequently bidirectional hybridization and introgression were detected between Gymnothorax pseudothyrsoideus and Gymnothorax reevesii , a species pair that overlapped in all the morphometric and meristic characters. Nevertheless, the principal component analysis indicated that each species pair has evolved significant morphological divergence, further supporting their taxonomic validities. Our results document the natural hybridization of marine eel taxa for the first time and reveal a diverse evolutionary process among the morays.

Three pairs of sesquiterpene enantiomers from Chloranthus multistachys pei - Wei-ming Huang; Fang-you Chen; Yu-ting Bian; Tian-jiao Ning; Zhi-chao Chen; Peng-cheng Shuang; Yong-ming Luo (Natural Product Research, 2022)

Shyer fish are superior swimmers in Siberian sturgeon (Acipenser baerii) - Lingli Xiang; Xiangyuan Mi; Yingchao Dang; Yu Zeng; Wei Jiang; Hao Du; William M. Twardek; Steven J. Cooke; Jianghui Bao; Ming Duan (Frontiers in Marine Science, 2022)
Differences in individual personality are common amongst animals, which can play an ecological and evolutionary role given links to fitness. Personality affects animal life processes and outputs (e.g., behavior, life history, growth, survival, reproduction), and has become a common theme in animal behavioral ecology research. In the present study, we used Siberian Sturgeon to explore how personality traits of boldness and shyness are related to swimming performance, post exercise recovery and phenotypic morphology. Firstly, our results indicated that the Siberian sturgeon juveniles of shyness were better swimmers, validating evolutionary biology trade-off theory. The critical swimming speed (U crit ) of the shy groups was higher than that of the bold groups. Secondly, the shy groups were more resilient after exercise fatigue. The swimming fatigue recovery ability, the glucose and lactic acid concentration recovery ability of shy groups were greater than that of bold groups. Thirdly, the shy groups were more streamlined. Compared with bold groups, shy groups had smaller caudate stalk lengths, caudate stalk heights, superior caudal lobes, and inferior caudal lobes. In general, we demonstrated that shy Siberian sturgeon had better swimming performance from physiology and morphology. These research results further enrich the theoretical viewpoints of fish behavior biology, more importantly, which provided a good example for studying the relationship between sturgeon’s “personality” and swimming performance.

Research on the Hydrodynamic Performance of a Horizontal-Axis Tidal Current Turbine with Symmetrical Airfoil Blades Based on Swept-Back Models - Yu-Ting Yan; Shi-Ming Xu; Cong Liu; Xiao Zhang; Jian-Mei Chen; Xue-Ming Zhang; Yong-Jun Dong (Journal of Marine Science and Engineering, 2022)
For the design of a horizontal-axis tidal current turbine with adaptive variable-pitch blades, both numerical simulations and physical model experiments were used to study the hydrodynamic performance of symmetrical airfoil blades based on backward swept models. According to the lift–drag ratio of symmetrical airfoils, variable airfoil sections were selected for each part of the blade in the spanwise direction. Then, three kinds of blades were designed by using different swept-back models from wind turbines. A rotation model with a multi-reference frame was employed to conduct a three-dimensional steady numerical simulation of the turbine model based on the CFD method. The axial thrust and energy-capturing efficiency under different tip speed ratios, as well as the corresponding starting torque under different flow rates, were analyzed. The simulation results indicate that model 2 has optimal start-up performance, and model 3 has the largest power coefficient. The thrust coefficient of model 1 is the smallest. In all, model 2 has better comprehensive performance. The experiments of model 2 show that it has suitable hydrodynamic performance to capture bidirectional energy via passively variable pitch. This research provides an important solution for the design and optimization of horizontal-axis turbines to harvest bidirectional tidal current energy.

Evaluation of the Potential of the Hard Clam (Meretrix meretrix) Shell Which Can Be Used as the Bioindicator for Heavy Metal Accumulation - Yen-Ting Lin; Fang-Chi Chang; Ming-Tsung Chung; Ze-Kai Li; Chang-Chuan Chan; Ying-Sheng Huang; Kuo-Fang Huang; Yu-San Han (Fishes, 2022)
Clams, Meretrix meretrix, were one of the favorite aquatic products in Taiwan and the world. It was reported that the water pollutants such as heavy metals and chemicals might accumulate in the clam body and shell through filter-feeding behavior. Thus, the bivalves could be used as bioindicators in the aquatic environment. The present study analyzed 20 trace elements, Mg, Sr, Li, Cd, Ba, Mn, Al, U, Ti, Pb, Nd, B, S, Zn, Fe, P, Na, K, Cu, and Ni, in the shells of the clams collected from the wild coastal area and cultured ponds to evaluate which elements have the potential to be biomarkers. The concentrations of 20 elements were detected by Solution-Based Inductively Coupled Plasma Mass Spectrometry (SB-ICPMS). Among them, Cd, Al, U, Ti, Nd, S, and K were below the detection limit. The remaining elements were analyzed for accumulation. The levels of Zn, Fe, and Ni possess high variation in an identical environment; so, a PCA was conducted without these three elements to reduce noise. The PCA result proved that the clam could absorb specific trace elements from the habitat. After a period of time, the contents of the absorption in the shells of the clams living in an identical environment became more similar. The analyzed element, Pb, was not found with a special difference in this study. The levels of Na, Sr, Mg, B, Mn, P, Ba, Li, and Cu reflected different sampling sites, which suggested that these elements in the species M. meretrix had the potential to be used as biomarkers for assessing heavy metal accumulation in the environment.

Starvation shrinks the mussel foot secretory glands and impairs the byssal attachment - Yi Zheng; Yue-Ming Yang; Yue-Feng Xu; Yu-Qing Wang; Xue Shi; Gao-Hai Zheng; Yi-Feng Li (Frontiers in Marine Science, 2022)
Mussel is an economically and ecologically important species widely distributed throughout the world. The mussel adheres to the attachment substrate by secreting byssus external to the body. Various environmental and biological factors influence the process of byssus secretion, and the present study investigated the effect of starvation on byssal secretion in the hard-shelled mussel Mytilus coruscus . Histological changes in mussel foot secretory glands and gene expression of mussel foot proteins were also determined. The experimental setup consisted of starvation treatments for 7, 14 and 21 days, and the control groups. The results showed that the number of produced byssus was higher in the starvation group compared to the control (CTR) group, and the starvation group had a significantly higher of byssal shedding number from 6 days of starvation treatment onwards ( p < 0.05). The byssal thread diameter was significantly reduced in all starvation treatment groups ( p < 0.05). However, starvation treatment had no effect on the length of the byssal thread ( p > 0.05). After 21 days of starvation treatment, the byssal thread volume was significantly lower than that of the CTR group ( p < 0.05). A significant decrease in the breaking force of the byssal thread was observed after 14 and 21 days of starvation treatment ( p < 0.05), along with an upward shift in the breakpoints. Starvation treatment significantly reduced the percentage of foot secretory glands area to total tissue ( p < 0.05). The expression of the mussel foot protein genes ( Mcfp-1P and Mcfp-1T ) was significantly up-regulated at 7 days of starvation treatment ( p < 0.05). These findings reveal that starvation weakens byssal thread performance by influencing mussel foot secretory glands, which increases the dislodgment risks of suspended-cultured mussels.

Effect of different carbon sources on sulfate reduction and microbial community structure in bioelectrochemical systems - Jing-jing Pan; Lu-yu Tan; Qing-qing Fan; Xiang-yang Cao; Jun Huang; Yu-kang Gu; Tian-ming Chen (Environmental Science and Pollution Research, 2022)

A fast and robust method for plant count in sunflower and maize at different seedling stages using high-resolution UAV RGB imagery - Yi Bai; Chenwei Nie; Hongwu Wang; Minghan Cheng; Shuaibing Liu; Xun Yu; Mingchao Shao; Zixu Wang; Siyu Wang; Nuremanguli Tuohuti; Lei Shi; Bo Ming; et al. (Precision Agriculture, 2022)

The Key Role of Magnetic Resonance Imaging in the Detection of Neurodegenerative Diseases-Associated Biomarkers: A Review - Ke-Ru Li; An-Guo Wu; Yong Tang; Xiao-Peng He; Chong-Lin Yu; Jian-Ming Wu; Guang-Qiang Hu; Lu Yu (Molecular Neurobiology, 2022)

Effects of cervicothoracic postures on the stiffness of trapezius muscles - Hongying Liang; Suiqing Yu; Man Hao; Weixin Deng; Ming Lin; Zheng Zhang; Chunlong Liu (Medical & Biological Engineering & Computing, 2022)

Dietary supplementation of two indigenous Bacillus spp on the intestinal morphology, intestinal immune barrier and intestinal microbial diversity of Rhynchocypris lagowskii - Xin-yu Lei; Dong-ming Zhang; Qiu-ju Wang; Gui-qin Wang; Yue-hong Li; Yu-rou Zhang; Men-nan Yu; Qi Yao; Yu-ke Chen; Zhi-xin Guo (Fish Physiology and Biochemistry, 2022)

Genetic dissection of stage-dependent dry matter accumulation in maize (Zea mays L.) kernel - Jian-ju Liu; Hui Yu; Ming Xue; Bao-shen Liu; Ming-liang Xu; Sai-hua Chen (Euphytica, 2022)

Correction to: Characteristic pollutant purification analysis of modified phosphogypsum comprehensive utilization - Chao‑qiang Wang; De‑ming Xiong; Yu Chen; Kai Wu; Min‑jie Tu; Pei‑xin Wang; Zhao‑ji Zhang; Lei Zhou (Environmental Science and Pollution Research, 2022)

Construction of a target MSNs drugcarrier loaded with siRNAGLI1 and siRNASMO aim at hedgehog signal pathway and the pharmacodynamic study of drug-carriers in the treatment of leukemia stem cells - Yuan Zhang; Rui Cai; HaiJun Li; Yu Duan; Yan Zhang; Wei Jing; ShaoGang Lv; Xi Chu; Zheng Cao; Lei Yang; Liang Ming (Drug Delivery and Translational Research, 2022)

Baseflow variations and its causes in a subtropical watershed of southern China - Zheng Liu; Fei Sheng; Shi-yu Liu; Yan-yan Wang; Chang-ming Zhou; Chao-jun Gu (Journal of Mountain Science, 2022)

Potential Distribution of Seagrass Meadows Based on the MaxEnt Model in Chinese Coastal Waters - Ming Wang; Yong Wang; Guangliang Liu; Yuhu Chen; Naijing Yu (Journal of Ocean University of China, 2022)

Siccirubricoccus soli sp. nov., a novel bacterial species isolated from Jiaozi Mountain soil - Guo-Xing Zhu; Ya-Jie Wu; Yan-Ru Cao; Bing-Jun Fan; Yu Jiao; Xiu-Li Hou; Zi-Chao Liu; Yue Zhang; Jiang-Bo He; Lian-Ming Liang (Antonie van Leeuwenhoek, 2022)

Gregarious larval settlement mediates the responses of new recruits of the reef coral Acropora austera to ocean warming and acidification - Lei Jiang; Yu-Yang Zhang; Cheng-Yue Liu; Lin-Tao Huang; Hao-Ya Tong; Guo-Wei Zhou; Ming-Lan Guo; Tao Yuan; Hui Huang (Frontiers in Marine Science, 2022)
Gregarious larval settlement represents an important window for chimera formation in reef corals, yet it remains largely unknown how aggregated settlement and early chimerism could modify the performance and responses of coral recruits under elevated temperature and p CO 2 . In this study, single and aggregated recruits of the broadcast spawning coral Acropora austera were exposed to contrasts of two temperatures (28 versus 30.5°C) and p CO 2 levels (~500 versus 1000 μatm) for two weeks, and algal symbiont infection success, survivorship and growth were assessed. Results showed that symbiont infection success was mainly affected by temperature and recruit type, with reduced symbiont infection at increased temperature and consistently higher infection success in chimeric recruits compared to single recruits. Furthermore, although chimeric recruits with larger areal size had significantly higher survivorship in all treatments, the polyp-specific growth rates were considerably lower in chimeric entities than individual recruits. More importantly, the recruit type significantly influenced the responses of recruit polyp-specific growth rates to elevated temperature, with chimeras exhibiting lowered skeletal lateral growth under elevated temperature. These results demonstrate the benefits and costs associated with gregarious larval settlement for juvenile corals under ocean warming and acidification, and highlight the ecological role of larval settlement behavior in mediating the responses of coral recruits to climate change stressors.

The role of meteorological factors in suicide mortality in Wuhu, a humid city along the Yangtze River in Eastern China - Lingxiang Yu; Tingting Zhou; Ming Shao; Tao Zhang; Jinian Wang; Yubo Ma; Shanshan Xu; Yuting Chen; Jiansheng Zhu; Faming Pan (Environmental Science and Pollution Research, 2022)

Naturally-Occurring Antibodies Against Bim are Decreased in Alzheimer’s Disease and Attenuate AD-type Pathology in a Mouse Model - Jie-Ming Jian; Dong-Yu Fan; Ding-Yuan Tian; Yuan Cheng; Pu-Yang Sun; Cheng-Rong Tan; Gui-Hua Zeng; Chen-Yang He; Ye-Ran Wang; Jie Zhu; Xiu-Qing Yao; Yan-Jiang Wang; et al. (Neuroscience Bulletin, 2022)

Pathological Networks Involving Dysmorphic Neurons in Type II Focal Cortical Dysplasia - Yijie Shao; Qianqian Ge; Jiachao Yang; Mi Wang; Yu Zhou; Jin-Xin Guo; Mengyue Zhu; Jiachen Shi; Yiqi Hu; Li Shen; Zhong Chen; Xiao-Ming Li; et al. (Neuroscience Bulletin, 2022)

Potential antibacterial and anti-biofilm effects of Anoectochilus roxburghii rhizome cultures - Ming-Zhi Fan; Xiao-Long Jiang; Xuan-Chun Piao; Xue-Feng Li; Mei-Yu Jin; Mei-Lan Lian (Journal of Plant Biochemistry and Biotechnology, 2022)

The Effect of Co-Exposure to Glyphosate, Cadmium, and Arsenic on Chronic Kidney Disease - Junne-Ming Sung; Wei-Hsiang Chang; Kuan-Hung Liu; Chung Yu Chen; Trias Mahmudiono; Wan-Ru Wang; Ho-Chi Hsu; Zhen-Yi Li; Hsiu-Ling Chen (Exposure and Health, 2022)

Relationships Between Dietary Patterns and Low-Level Lead Exposure Among Children from Hunan Province of China - Zhi Huang; Xiao-chen Yin; Ming Chen; Mei-ling Li; Bo Chen; Yu-ming Hu (Exposure and Health, 2022)

Characteristic pollutant purification analysis of modified phosphogypsum comprehensive utilization - Chao-qiang Wang; De-ming Xiong; Yu Chen; Kai Wu; Min-jie Tu; Pei-xin Wang; Zhao-ji Zhang; Lei Zhou (Environmental Science and Pollution Research, 2022)

Negative air ion exposure ameliorates depression-like behaviors induced by chronic mild stress in mice - Yun-Qing Hu; Ting-Ting Niu; Jian-ming Xu; Li Peng; Qing-Hua Sun; Ying Huang; Ji Zhou; Yu-Qiang Ding (Environmental Science and Pollution Research, 2022)
The presence of negative air ions (NAI) is suggested to be a beneficial factor in improving psychological status and used in treating depression as an alternative approach. However, more biological evidence from animal models is needed to ensure the effects of NAI on the mood regulation, through which can facilitate identification of possible underlying mechanisms. In this study, the chronic mild stress (CMS) protocol was used to induce depressive-like behaviors in mice, and the effects of NAI exposure on CMS-induced depression-like behaviors were examined. Thirty-day NAI exposure prevented the CMS-induced depression-like behaviors as shown by the restoration of sucrose preference and reduced immobility time in the tail suspension test. In addition, the elevation of serous corticosterone was present in CMS-treated mice but not existed in those with the NAI exposure. Furthermore, we observed altered ratios of some cytokines secreted by type 1 T helper (Th1) cells and Th2 cells in CMS-treated mice, but it could be restored after NAI exposure. In conclusion, NAI intervention is able to ameliorate CMS-induced depression-like behaviors in mice, and this effect is associated with the alteration of corticosterone and functional rebalance between Th1 and Th2 cells.

Fractional contribution of global warming and regional urbanization to intensifying regional heatwaves across Eurasia - Gang Wang; Qiang Zhang; Ming Luo; Vijay P. Singh; Chong-Yu Xu (Climate Dynamics, 2022)

ZAKβ Alleviates Oxidized Low-density Lipoprotein (ox-LDL)-Induced Apoptosis and B-type Natriuretic Peptide (BNP) Upregulation in Cardiomyoblast - Yueh-Min Lin; Jiro Hasegawa Situmorang; Jia-Zun Guan; Dennis Jine-Yuan Hsieh; Jaw-Ji Yang; Michael Yu-Chih Chen; Ching-Hui Loh; Chia-Hua Kuo; Shang-Yeh Lu; Ying-Ming Liou; Chih-Yang Huang (Cell Biochemistry and Biophysics, 2022)

Fried-food consumption and risk of overweight/obesity, type 2 diabetes mellitus, and hypertension in adults: a meta-analysis of observational studies - Pei Qin; Dechen Liu; Xiaoyan Wu; Yunhong Zeng; Xizhuo Sun; Yanyan Zhang; Yang Li; Yuying Wu; Minghui Han; Ranran Qie; Shengbing Huang; Yang Zhao; et al. (Critical Reviews in Food Science and Nutrition, 2022)

Genetic Variations and Expansion of the Blue Swimmer Crab (Portunus pelagicus) in Southeast Asia - Yu-Ming Lu; Chun-Han Shih; Po-Cheng Chen; Wei-Chieh Kao; Ying-Chou Lee; Yu-San Han; Tzong-Der Tzeng (Journal of Marine Science and Engineering, 2022)
Blue swimmer crabs (Portunus pelagicus) primarily inhabit the coastal regions of Southeast Asia. This study aimed to examine their population genetic structure, phylogeography, and historical demography by applying partial sequences to the control region in the mitochondrial DNA. The analysis focused on 6 populations comprising 166 individual samples collected from Taiwan (Kezailiao Kaohsiung (KK) and Penghu (PH)), mainland China (Xiamen (XM) and Hong Kong (HK)), Vietnam (Hanoi (VN)), and Singapore (SGP). The estimated nucleotide diversity (π) for all of the samples was 0.062, with values ranging between 0.018 (PH) and 0.045 (HK). Our study collected 116 haplotypes and classified them into lineages A and B. The XM, HK, VN, and SGP populations made up lineage A, and the PH and KK populations comprised lineage B. For each lineage, the results highlighted indications of demographic expansion. Lineage A can be traced back to the second-to-last interglacial period, while lineage B possibly originated in the last glacial period. There were significant differences in the FST values among the six populations, except for the pairs HK–XM and PH–KK. In conclusion, the phylogeography and genetic structure of P. pelagicus in Southeast Asia were potentially affected by the Pleistocene glacial cycles and human introduction. These findings further highlight the possible dispersal routes of P. pelagicus throughout Southeast Asia.

Retraction Note: The highly efficient NDH-dependent photosystem I cyclic electron flow pathway in the marine angiosperm Zostera marina - Ying Tan; Quan Sheng Zhang; Wei Zhao; Zhe Liu; Ming Yu Ma; Ming Yu Zhong; Meng Xin Wang (Photosynthesis Research, 2022)

Role of host plants in the suitability and dispersal of an omnivorous predator Arma chinensis Fallou (Hemiptera: Pentatomidae: Asopinae) in a biological control context - Ming-Zhen Pan; Zhi-Xiao Fu; Yu-Yan Li; Hong-Yin Chen; Li-Sheng Zhang; Tong-Xian Liu (Journal of Plant Diseases and Protection, 2022)

Ketone Body Rescued Seizure Behavior of LRP1 Deficiency in Drosophila by Modulating Glutamate Transport - Jin-Ming Zhang; Ming-Jie Chen; Jiong-Hui He; Ya-Ping Li; Zhi-Cai Li; Zi-Jing Ye; Yong-Hui Bao; Bing-Jun Huang; Wen-Jie Zhang; Ping Kwan; Yu-Ling Mao; Jing-da Qiao (Journal of Molecular Neuroscience, 2022)

rhEPO Upregulates the PPARγ Pathway in Long-term Cultured Primary Nerve Cells via PI3K/Akt to Delay Cell Senescence - Huqing Wang; Ming Chen; Tao Zhang; Zhen Gao; Yu Gong; Xiaorui Yu; Haiqin Wu (Journal of Molecular Neuroscience, 2022)

Trochanteric Nails for the Reduction of Intertrochanteric Fractures: A Biomechanical Analysis Based on Finite Element Analysis and DIC System - Ming-Tzu Tsai; Cheng-Hung Lee; Kun-Hui Chen; Yu-Chun Yen; Chun-Hsiang Wang; Shun-Ping Wang; Kuo-Chih Su (Journal of Medical and Biological Engineering, 2022)
Purpose Intertrochanteric fractures are common among femoral fractures in the elderly population. The trochanteric nail is a standard internal fixator used in treating femoral intertrochanteric fractures. The technique of femoral fracture reduction affects the postoperative outcome. Here, we applied finite element analysis (FEA) to study mechanical effects of different reduction approaches using the trochanteric nail in treating both stable and unstable intertrochanteric fractures. Methods We combined FEA and in vitro experiments using a digital imaging correlation (DIC) technique to study effects of different alignment conditions after treating 4 cases of intertrochanteric fractures using the trochanteric nail system. A downward force of 2250 N was applied to the femoral head, and the distal end of the femur was fixed. The observed indicators were the femur displacement, together with the stress on the femur and trochanteric nail system. In addition, the displacement distribution was analyzed using DIC. Results In the case of space reduction, the force was transmitted by the trochanteric nail system, resulting in greater stress imposed on the femur or the trochanteric nail system. In the case of closed reduction, the stress was much smaller. In the case of unstable fracture reduction, closed reduction was associated with a smaller contact area at the fracture site, resulting in greater stress on both trochanter and the trochanteric nail system. Conclusion When the trochanteric nail system was used for fixation, the fracture site was well aligned, reducing the stress on the femur or the trochanteric nail.

Biomechanical analysis of new cross locking plates for metacarpal neck fracture - Chen-Yuan Yang; Ting-Yu Liu; Jui-Ting Hsu; Ming-Tzu Tsai (Journal of Medical and Biological Engineering, 2022)

Biomechanical Analysis of Mandibular Implant-Assisted Removable Partial Denture with Distal Extension - Yung-Chung Chen; Chi-Lun Lin; Chen-Han Yu; Hung-Chih Chang; Yang-Ming Lin; Jia-Wei Lin (Journal of Medical and Biological Engineering, 2022)

Modification effects of seasonal and temperature variation on the association between exposure to nitrogen dioxide and ischemic stroke onset in Shenzhen, China - Yuchen Tian; Ming Xiang; Ji Peng; Yanran Duan; Ying Wen; Suli Huang; Lei Li; Shuyuan Yu; Jinquan Cheng; Xia Zhang; Peng Wang (International Journal of Biometeorology, 2022)

Proteomic analysis of coarse and fine skin tissues of Liaoning cashmere goat - Zhixian Bai; Yanan Xu; Ming Gu; Weidong Cai; Yu Zhang; Yuting Qin; Rui Chen; Yinggang Sun; Yanzhi Wu; Zeying Wang (Functional & Integrative Genomics, 2022)

Theoretical evidence for the formation of perfluorocarboxylic acids form atmospheric oxidation degradation of fluorotelomer acrylates - Yanhui Sun; Lin Liu; Ming Li; Fei Xu; Wanni Yu (Environmental Science and Pollution Research, 2022)

Assessment of brain connectome alterations in male chronic smokers using structural and generalized q-sampling MRI - Jun-Cheng Weng; Yu-Chen Chuang; Li-Bang Zheng; Ming-Shih Lee; Ming-Chou Ho (Brain Imaging and Behavior, 2022)

Asymmetric Structures of a Squall-Line MCS over Taiwan with Significant Hydraulic Jumps - Yu-Tai Pan; Ming-Jen Yang (Asia-Pacific Journal of Atmospheric Sciences, 2022)
On 19 April 2019, a mature squall-line mesoscale convective system (MCS) with the characteristics of a leading convective line and trailing stratiform landed on Taiwan, resulting in strong gust wind and heavy rainfall. This squall-line MCS became asymmetric after landfall on Taiwan. Two sets of idealized numerical simulations (mountain heights and low-level vertical wind shear) using the Weather Research and Forecasting (WRF) model were conducted to examine the impacts of realistic Taiwan topography on a squall-line MCS. Results showed numerous similarities between the idealized simulations and real-case observations. The low-level Froude number which considered the terrain height (F mt ) was calculated to examine the blocking effect of the Taiwan terrain, and the cold pool (determined by − 1.5 K isotherm) was found to be completely blocked by the 500-m height contour. The northeast-southwest orientation of the Snow Mountain Range (SMR), and the north–south orientation of the Central Mountain Range (CMR) led to the upwind side asymmetry. On the other hand, the lee-side asymmetry was associated with different intensities and occurrence locations of the hydraulic jump between the SMR and southern CMR, and the cold-pool Froude number (F cp ) indicated the flow-regime transition from subcritical to supercritical.

Nematicidal activity of volatile organic compounds produced by Bacillus altitudinis AMCC 1040 against Meloidogyne incognita - Lin Ye; Jian-Yu Wang; Xiao-Fang Liu; Qi Guan; Nong-Xiao Dou; Jian Li; Qian Zhang; Yan-Ming Gao; Min Wang; Jian-She Li; Bo Zhou (Archives of Microbiology, 2022)

Cohnella mopanensis sp. nov., a new Gram-negative bacterium isolated from soil in Xinping Mountain National Forest Park - Jing Tang; Jiang-Yuan Zhao; Le-Le Li; Zhang-Gui Ding; Shi-Qiang Ye; Cheng Ling; Meng-Yu Zhang; Song-Guo Liang; Jian-Yu Li; Pei-Wen Yang; Jiao Xiong; Lu-Yao Feng; et al. (Archives of Microbiology, 2022)

Comparison between the exotic Coreopsis grandiflora and native Dendranthema indicum across variable nitrogen deposition conditions - Li-Jun Xing; Ming-Yan Li; Si-Yu Jiang; Wei Li; Shao-Xia Guo; Hai-Mei Li; Xiao Guo (Acta Physiologiae Plantarum, 2022)

First report of stem and root rot on Plectranthus hadiensis var. tomentosus caused by Fusarium odoratissimum in China - Ming-Yue Xu; Jian-Wei Jiang; Peng-Yu Liang; Yi Zhou (Journal of Plant Pathology, 2022)

Correction to: First report of Botrytis cinerea causing gray mold on Arachis hypogaea in Chongqing, China - Ming Yang; Zhiliang Zhang; Xia Zhang; Yu Wu; Qiuyue Wang; Xiaochun Zhang (Journal of Plant Pathology, 2022)

Genome characterization and comparative analysis among three swimming crab species - Ming Liu; Shanshan Ge; Shivish Bhandari; Chunlei Fan; Yu Jiao; Chunlei Gai; Youhong Wang; Hongjun Liu (Frontiers in Marine Science, 2022)
In this study we sequenced the genomes of three economically important swimming crabs Portunus trituberculatus, Charybdis japonica , and Callinectes sapidus using the next-generation sequencing approach and made a basic assembly. The genomes of the three species are characterized with high heterozygosity (>1.2%) and high repeat content (>50%). Genome comparative analysis revealed 40 long conserved fragments (>5,000 bp) among the three species, most of them are involved in cardiac-related biological process. Relative higher genome similarity was found between P. trituberculatus and C. japonica that are belong to different subfamilies, compared to that between P. trituberculatus and C. sapidus which are from the same subfamily. It is inconsistent with their phylogenetic evolutionary trees inferred from previous mitochondrial DNA coding fragments and a conserved ANK2 protein fragment from this study. We speculated that the high genome similarity between P. trituberculatus and C. japonica might be attributed to their same inhabit range in which the genome is subject to the same environment selection, and the inconsistence between genome similarity and phylogenetic relationship is caused by the different evolutionary rates of coding DNA and non-coding DNA under environment selection.

Effects of Microplastics on Reproduction and Growth of Freshwater Live Feeds Daphnia magna - Chih-Hsiung Huang; Tah-Wei Chu; Chiu-Hui Kuo; Ming-Chang Hong; Yu-Yun Chen; Bonien Chen (Fishes, 2022)
In recent years, much research has focused on studying the damage caused by microplastics to the ecological environment and human health. Indeed, MPs are often consumed by shellfishes and zooplanktons due to their similarity in size to POM (particular organic matter). Especially in zooplankton, the accumulation of MPs in the body affects the reproductive system and the growth rate of juveniles. Moreover, toxins derived from MPs are continuously accumulated in predators of zooplankton and impact the whole ecosystem across the food chain. In this work, we found that even though MPs were internalized by and adherent around Daphnia magna, there were no significant differences in the survival rate of their adults and offspring. However, the population of ovigerous adults under high MPs exposure for 7 days decreased significantly, suggesting an extension of the days of sexual maturity in D. magna. The removal of MPs after 7 days’ MPs treatment resulted in an increase in D. magna juveniles and neonates which indicated their growth was reduced or inhibited in the MPs environment. Overall, the uptake of MPs led to negative effects on population reproduction and the growth of offspring in D. magna.

Fissistiganoids A and B: two new flavonoids from the Fissistigma tungfangense - Wan-Lin Zhong; Xue-Ming Zhou; Ji-Ling Yi; Xin-Ming Song; Bin Zhang; Jing-Yu Yang; Guang-Ying Chen (Natural Product Research, 2022)

Knockdown of Two Iodothyronine Deiodinase Genes Inhibits Epinephrine-Induced Larval Metamorphosis of the Hard-Shelled Mussel Mytilus coruscus - Xue Shi; Yu-Qing Wang; Yue-Ming Yang; Yi-Feng Li (Frontiers in Marine Science, 2022)
The metamorphosis process is a critical life-changing event for marine invertebrate planktonic larvae to transform into benthic adults, which is crucial for the shellfish bed’s ecosystem stability and seed production in aquaculture. The mechanism of neuroendocrine regulation in the larval metamorphosis of bivalves remains ambiguous. In the present study, the expression of two deiodinase genes, McDx and McDy , was analyzed by whole-mount in situ hybridization at four larval stages in the hard-shelled mussel Mytilus coruscus . The McDx and McDy localized in visceral tissues, nervous system, mantle, and velum, indicating that two deiodinase genes are essential for larval development in M. coruscus . Knockdown of the McDx and McDy in the pediveliger larvae of M. coruscus using electroporation of siRNA significantly ( p < 0.001) reduced McDx and McDy expression. McDx and McDy knockdown reduced larval metamorphosis in 45% and 49% of the pediveliger larvae induced by epinephrine (EPI). It is hypothesised that the knockdown effects of McDx and McDy repress metamorphic induction rather than larval viability, which does not elicit a lethal effect. The present study corroborates a synergistic action of the adrenergic and thyroid hormones signalling pathway in M. coruscus , and suggests the role of McDx and McDy in larval development and metamorphic transition.

First report of Botrytis cinerea causing gray mold on Arachis hypogaea in Chongqing, China - Ming Yang; Zhiliang Zhang; Xia Zhang; Yu Wu; Qiuyue Wang; Xiaochun Zhang (Journal of Plant Pathology, 2022)

Lattice Boltzmann simulation for grout filling process during simultaneous backfill grouting of shield in tunnel construction - Chang-ming Hu; Jian-xia Guo; Zhi-yu Wang (European Journal of Environmental and Civil Engineering, 2022)

Construction of an N6-methyladenosine lncRNA- and immune cell infiltration-related prognostic model in colorectal cancer - Zhong Lin Yu; Zheng Ming Zhu (Protoplasma, 2022)

Correction to: Matrine Treatment Blocks NogoA-Induced Neural Inhibitory Signaling Pathway in Ongoing Experimental Autoimmune Encephalomyelitis - Quan-Cheng Kan; Hui-Jun Zhang; Yuan Zhang; Xing Li; Yu-Ming Xu; Rodolfo Thome; Ming-Liang Zhang; Nan Liu; Yao-Juan Chu; Guang-Xian Zhang; Lin Zhu (Molecular Neurobiology, 2022)

Outburst debris flow of Yusui Stream caused by a large-scale Silabaku landslide, Southern Taiwan - Che-Ming Yang; Wei-An Chao; Meng-Chia Weng; Yu-Yao Fu; Jui-Ming Chang; Wei-Kai Huang (Landslides, 2022)

Increases in temperature response to CO2 emissions in biochar-amended vegetable field soil - Rong Huang; Zifang Wang; Yi Xiao; Luo Yu; Xuesong Gao; Changquan Wang; Bing Li; Qi Tao; Qiang Xu; Ming Gao (Environmental Science and Pollution Research, 2022)

Aquapteridospora jiangxiensis, a new aquatic hyphomycetous fungus from a freshwater habitat in China - Su-Qin Peng; Yu-Lin Liu; Jun-En Huang; Xiao-Hong Li; Xin-Yi Yan; Hai-Yan Song; Yang Gao; Zhi-Jun Zhai; Yuan-Qiu Liu; Dian-Ming Hu (Archives of Microbiology, 2022)

Understanding the social impacts of enforcement activities on illegal wildlife trade in China - Sifan Hu; Yu Cheng; Rong Pan; Fasheng Zou; Tien Ming Lee (Ambio, 2022)
Illegal wildlife trade enforcement is a cornerstone conservation strategy worldwide, yet we have a limited understanding on its social impacts. Using Chinese online wildlife seizure news (2003–2018), we evaluated the interactions among enforcement operations, news frequency, and social engagement (i.e., whistle-blowing) frequency. Our results showed that intensive enforcement operations, which commenced after 2012, have social impacts by increasing the frequency of all seizure news significantly by 28% [95% Confidence Interval (CI): 5%, 51%] and those via whistle-blowing by 24% [95% CI: 2%, 45%], when compared to counterfactual models where possible confounding factors were accounted for. Furthermore, we revealed the potential interaction between enforcement seizure news with and without social engagement, and the consequential social feedback process. Of the species identified from ‘whistle-blowing’ news, up to 28% are considered as high conservation priorities. Overall, we expanded our understanding of the enforcement impacts to social dimensions, which could contribute to improving the cost-effectiveness of such conservation efforts.

The Landscape of Genome-Wide and Gender-Specific Microsatellites in Indo-Pacific Humpback Dolphin and Potential Applications in Cetacean Resource Investigation - Yao Ming; Xueying Yu; Wei Liu; Jingzhen Wang; Wenhua Liu (Journal of Marine Science and Engineering, 2022)
Microsatellites are one of the important genome characterizations that can be a valuable resource for variety identification, genetic diversity, phylogenetic analysis, as well as comparative and conservation genomics research. Here, we developed comprehensive microsatellites through genome-wide mining for the threatened cetacean Indo-Pacific humpback dolphin (Sousa chinensis). We found 87,757 microsatellites with 2–6 bp nucleotide motifs, showing that about 32.5 microsatellites per megabase comprises microsatellites sequences. Approximately 97.8% of the markers developed in this study were consistent with the published identified markers. About 75.3% microsatellites were with dinucleotide motifs, followed by tetranucleotide motifs (17.4%), sharing the same composition pattern as other cetaceans. The microsatellites were not evenly distributed in the S. chinensis genome, mainly in non-coding regions, with only about 0.5% of the markers located in coding regions. The microsatellite-containing genes were mainly functionally enriched in the methylation process, probably demonstrating the potential impacts of microsatellites on biological functions. Polymorphic microsatellites were developed between different genders of S. chinensis, which was expected to lay the foundation for genetic diversity investigation in cetaceans. The specific markers for a male Indo-Pacific humpback dolphin will provide comprehensive and representative male candidate markers for sex identification, providing a potential biomolecular tool for further analysis of population structure and social behavior of wild populations, population trend evaluation, and species conservation management.

Estrogenic and anti-neutrophilic inflammatory phenanthrenes from Juncus effusus L. - Hao-Chun Hu; Yi-Hong Tsai; Yu-Che Chuang; Kuei-Hung Lai; Yu-Ming Hsu; Tsong-Long Hwang; Chih-Chan Lin; Ferenc Fülöp; Yang-Chang Wu; Szu-Yin Yu; Yu-Ting Kuo; Fang-Rong Chang (Natural Product Research, 2022)

Diversity and Structure of Demersal Fish Community Over the Northern Slope in the South China Sea - Jun Zhang; Kui Zhang; Yan-e Jiang; Yuan-jie Li; Jiang-tao Fan; Wen-ming Yu; Zuo-zhi Chen (Frontiers in Marine Science, 2022)
Three bottom trawl surveys over the northern continental slope in the South China Sea (18°50′–20°40′N, 112°50′–115°10′E) were carried out, in June 2015, March 2017 and September 2018, to investigate species composition, biodiversity and community structure of demersal fish. Surveys in 2015, 2017 and 2018 captured 97 fish species (representing 77 genera, 52 families, 26 orders), 108 fish species (representing 84 genera, 61 families, 19 orders) and 126 fish species (representing 105 genera, 74 families, 25 orders), respectively. Three surveys captured a total of 252 fish species, representing 164 genera, 97 families, 30 orders. Perciformes dominated. Species richness in station linking shallow continental shelf with deep slope was the lowest among stations. In three surveys, 16 species occurred in the catches of three surveys, accounting for 6.35% of all species. Species replacement rate between stations showed a significant linear relationship with the depth difference and latitude difference. Margalef’s species richness index ( D ), Shannon–Weiner diversity index ( H’ ) and Pielou’s evenness index ( J’ ) among stations ranged 2.65–6.74, 1.02–4.15 and 0.28–1.14, respectively. Differences of D , H ’ and J ’ were insignificant among seasons. There were significant positive linear relations between H’ and J’ and latitude. D , H’ and J’ decreased with increasing sampling depth, however the relations were not significant. Based on multivariate statistical analysis, fish community at species level was divided into five groups with average dissimilarities of 95.69%–99.96%. In terms of genus and family, average dissimilarities among groups were more than 88.11% and 82.69%. There were significant differences in species composition between depths, but no significant differences between seasons and temperatures, as well as in genus and family composition.

Millifolide A, a dimeric ether of degraded sesquiterpene lactones, inhibited the proliferation of human lung cancer cell line A549 - Pan-Pan Yu; Feng Yu; Wen-Zhe Li; Si-Ming Wang; Chuan Wang; Mei Dong; Zhi-Yu Ni; Yong Li; Hiromasa Kiyota (Natural Product Research, 2022)

Characterization of Water Transport in Porous Building Materials Based on an Analytical Spontaneous Imbibition Model - Ming-Liang Qu; Sheng-Yue Lu; Qingyang Lin; Sajjad Foroughi; Zi-Tao Yu; Martin J. Blunt (Transport in Porous Media, 2022)

Comparison of the Infant and Adult Adipose-Derived Mesenchymal Stem Cells in Proliferation, Senescence, Anti-oxidative Ability and Differentiation Potential - Szu-Hsien Wu; Jin-Huei Yu; Yu-Ting Liao; Kuo-Hao Liu; En-Rung Chiang; Ming-Chau Chang; Jung-pan Wang (Tissue Engineering and Regenerative Medicine, 2022)

Identification of the Largest SCA36 Pedigree in Asia: with Multimodel Neuroimaging Evaluation for the First Time - Yue Xie; Zhao Chen; Zhe Long; Rui-Ting Chen; Yi-Zheng Jiang; Ming-Jie Liu; Lin-Liu Peng; Hui-Rong Peng; Na Wan; Guangdong Zou; Chun-Rong Wang; Yu-Ting Shi; et al. (The Cerebellum, 2022)

Lactobacillus plantarum PS128 Promotes Intestinal Motility, Mucin Production, and Serotonin Signaling in Mice - Chih-Ming Chen; Chien-Chen Wu; Chin-Lin Huang; Min-Yu Chang; Shih-Hsuan Cheng; Ching-Ting Lin; Ying-Chieh Tsai (Probiotics and Antimicrobial Proteins, 2022)
Lactobacillus plantarum PS128 has been reported as a psychobiotic to improve mental health through the gut–brain axis in experimental animal models. To explore its mechanism of action in the gut, this study aimed to analyze the effects of L. plantarum PS128 ingestion on naïve and loperamide (Lop)-induced constipation mice. We found that, in the two mouse models, the weight, number, and water content of feces in the L. plantarum PS128 group were higher than those in the vehicle control group. Histological observation revealed that L. plantarum PS128 increased the level of colonic mucins including the major mucin MUC2. In addition, the charcoal meal test showed that L. plantarum PS128 significantly increased the small intestine transit in naïve mice, but not in the Lop-treated mice. Since intestinal serotonin has been found to modulate motility, we further analyzed the expression of genes related to serotonin signal transduction in the small intestine of naïve mice. The results showed that L. plantarum PS128 significantly altered the expression levels of Tph1 , Chga , Slc6a4 , and Htr4 , but did not affect the expression levels of Tph2 , Htr3a , and Maoa . Furthermore, immunohistochemistry revealed that L. plantarum PS128 significantly increased the number of serotonin-containing intestinal cells in mice. Taken together, our results suggest that L. plantarum PS128 could promote intestinal motility, mucin production, and serotonin signal transduction, leading to a laxative effect in mice.

Effects of vegetation restoration on soil carbon dynamics in Karst and non-karst regions in Southwest China: a synthesis of multi-source data - Xiao-Cong Zhu; Ming-Guo Ma; Ryunosuke Tateno; Xin-Hua He; Wei-Yu Shi (Plant and Soil, 2022)

A Deep Mesencephalic Nucleus Circuit Regulates Licking Behavior - Di Zheng; Jia-Yu Fu; Meng-Yu Tang; Xiao-Dan Yu; Yi Zhu; Chen-Jie Shen; Chun-Yue Li; Shi-Ze Xie; Shan Lin; Minmin Luo; Xiao-Ming Li (Neuroscience Bulletin, 2022)

Genotyping and Drug Resistance Profile of Clinical Isolates of Candida albicans from Vulvovaginal Candidiasis in the Eastern China - Nan Hong; Yan Lei; Huan Chen; Xiaofei Chen; Kin Ming Tsui; Danyang Hu; Wanqing Liao; Liang Yan; Hong Zhang; Rongfen Zhao; Gang Wu; Nong Yu; et al. (Mycopathologia, 2022)
A total of 244 Candida albicans isolates recovered from vulvovaginal candidiasis (VVC) patients in Suzhou, Eastern China, were investigated. According to CLSI documents M27-A4 and M59-3ed/M60-2ed, the MIC geometric means of nine antifungals in increasing order were micafungin (0.048 mg/L), anidulafungin (0.132 mg/L), caspofungin (0.19 mg/L), itraconazole (0.23 mg/L), posaconazole (0.25 mg/L), voriconazole (0.28 mg/L), 5-flucytosine (0.44 mg/L), amphotericin B (0.49 mg/L) and fluconazole (2.01 mg/L) respectively. Of note, 6.5% (16/244) C. albicans isolates showed resistance mainly to anidulafungin (mono-echinocandin resistance), while voriconazole had the lowest susceptibility rate of 34.8% (85/244), followed by fluconazole 59.4% (145/244), respectively. All isolates were genotyped by allelic combination of 3 microsatellite markers (CEF3, CAIII and LOC4). A total of 129 different allelic genotypes were identified, in which seven different clades were recognized with a discriminatory power of 0.96. Genotypes A-D were present in 35% of the isolates. In conclusion, decrease in antifungal drug susceptibility to C. albicans isolates from VVC is alarming. Our findings revealed the genetic diversity of C. albicans isolates among VVC patients and provided insights into the molecular epidemiology of Candida infections in China.

Correction to: Sox10 Gene Is Required for the Survival of Saccular and Utricular Hair Cells in a Porcine Model - Jing-cui Qi; Qing-qing Jiang; Long Ma; Shuo-long Yuan; Wei Sun; Li-sheng Yu; Wei-wei Guo; Shi-ming Yang (Molecular Neurobiology, 2022)

Sox10 Gene Is Required for the Survival of Saccular and Utricular Hair Cells in a Porcine Model - Jing-cui Qi; Qing-qing Jiang; Long Ma; Shuo-long Yuan; Wei Sun; Li-sheng Yu; Wei-wei Guo; Shi-ming Yang (Molecular Neurobiology, 2022)

Wuzi Yanzong pill attenuates MPTP-induced Parkinson’s Disease via PI3K/Akt signaling pathway - Wei Hang; Hui-jie Fan; Yan-rong Li; Qi Xiao; Lu Jia; Li-juan Song; Yao Gao; Xiao-ming Jin; Bao-guo Xiao; Jie-zhong Yu; Cun-gen Ma; Zhi Chai (Metabolic Brain Disease, 2022)

Regulation of wound healing and fibrosis by galectins - Dong Yu; Ming Bu; Ping Yu; Yaping Li; Yang Chong (Journal of Molecular Medicine, 2022)

Morphological observations of haemocytes from Agrotis ipsilon (Lepidoptera: Noctuidae) larvae infected by Escherichia coli - Yu-yong Xiang; Ming Ni; Pei-feng Yin; Yuan-chang Zhang (International Journal of Tropical Insect Science, 2022)

FLO8 deletion leads to decreased adhesion and virulence with downregulated expression of EPA1, EPA6, and EPA7 in Candida glabrata - Jun-Tao Zhao; Ke-Zhi Chen; Jin-Yan Liu; Wei-Hua Li; Yu-Zhu Wang; Lu-Ling Wang; Ming-Jie Xiang (Brazilian Journal of Microbiology, 2022)

Therapeutic Effects of Sodium Para-Aminosalicylic Acid on Cognitive Deficits and Activated ERK1/2-p90RSK/NF-κB Inflammatory Pathway in Pb-Exposed Rats - Li-li Lu; Yu-wen Zhang; Zhao-cong Li; Yuan-yuan Fang; Lei-lei Wang; Yue-song Zhao; Shao-jun Li; Shi-yan Ou; Michael Aschner; Yue-ming Jiang (Biological Trace Element Research, 2022)

Estrogen Deficiency Aggravates Fluoride-Induced Liver Damage and Lipid Metabolism Disorder in Rats - Ya-ming Yu; Bian-hua Zhou; Yi-lin Yang; Cheng-Xiang Guo; Jing Zhao; Hong-wei Wang (Biological Trace Element Research, 2022)

Recent Advances in Technologies for Removal of Microcystins in Water: a Review - Ming-ming Zhan; Yu Hong (Current Pollution Reports, 2022)

Qipengyuania thermophila sp. nov., isolated from a Chinese hot spring - Zi-Yu Zhao; Ting-Ting Xia; Jian-Yu Jiao; Lan Liu; Qing-Yang Su; Meng-Meng Li; Ai-Ping Lv; Yu-Ting Ouyang; Wen-Jun Li; Hong Ming (Archives of Microbiology, 2022)

Jeotgalibacillus aurantiacus sp. nov., a novel orange-pigmented species with a carotenoid biosynthetic gene cluster, isolated from wetland soil - Hui-Ning Jiang; Shuai-Ting Yun; Bao-Xun Wang; Ming-Jing Zhang; Yu Ma; Yan-Xia Zhou (Antonie van Leeuwenhoek, 2022)

Mechanical properties distribution of lime-fly ash solidified oil contaminated soil in a coastal environment - Min Li; Cong Ma; Zhao Ming Sun; Xin Yu Yao (European Journal of Environmental and Civil Engineering, 2022)

Shear Instability and Turbulent Mixing in the Stratified Shear Flow Behind a Topographic Ridge at High Reynolds Number - Jia-Lin Chen; Xiao Yu; Ming-Huei Chang; Sen Jan; Yiing Jang Yang; Ren-Chieh Lien (Frontiers in Marine Science, 2022)
Observations on the lee of a topographic ridge show that the turbulence kinetic energy (TKE) dissipation rate due to shear instabilities is three orders of magnitude higher than the typical value in the open ocean. Laboratory-scale studies at low Reynolds number suggest that high turbulent dissipation occurs primarily within the core region of shear instabilities. However, field-scale studies indicate that high turbulence is mainly populated along the braids of shear instabilities. In this study, a high-resolution, resolving the Ozmidov-scale, non-hydrostatic model with Large Eddy Simulation (LES) turbulent closure is applied to investigate dominant mechanisms that control the spatial and temporal scales of shear instabilities and resulting mixing in stratified shear flow at high Reynolds number. The simulated density variance dissipation rate is elevated in the cusp-like bands of shear instabilities with a specific period, consistent with the acoustic backscatter taken by shipboard echo sounder. The vertical length scale of each cusp-like band is nearly half of the vertical length scale of the internal lee wave. However, it is consistent with instabilities originating from a shear layer based on linear stability theory. The model results indicate that the length scale and/or the period of shear instabilities are the key parameters to the mixing enhancement that increases with lateral Froude number Fr L , i.e. stronger shear and/or steeper ridge.

Two new compounds from a mangrove sediment-derived fungus Penicillium polonicum H175 - Shun-Zhi Liu; Xi-Xiang Tang; Feng-Ming He; Jian-Xin Jia; Hang Hu; Bao-Ying Xie; Ming-Yu Li; Ying-Kun Qiu (Natural Product Research, 2022)

A new highly oxygenated germacranolide from Carpesium nepalense var. lanatum (C.B.Clarke) Kitam - Yi-Fan Yu; Yue-Qian Li; Ru-Yue Wang; Xu Liu; Wen-Bo Cui; Xiao-Han Chen; Cheng-Mu Zhao; Feng-Ming Qi; Zhan-Xin Zhang; Dong-Qing Fei (Natural Product Research, 2022)

Comparative effects of cannabinoid CB1 receptor agonist and antagonist on timing impulsivity induced by d-amphetamine in a differential reinforcement of low-rate response task in male rats - Shuo-Fu Chen; Wei-Chung Hsu; Xi-Yun Lu; Chuen-Yu Chuang; Ruey-Ming Liao (Psychopharmacology, 2022)

Interleukin-6 transiently promotes proliferation of osteoclast precursors and stimulates the production of inflammatory mediators - Peng-Yuan Chang; Hung-Kang Wu; Yu-Hsu Chen; Yu-Pao Hsu; Ming-Te Cheng; Ching-Hsiao Yu; Shau-Kwaun Chen (Molecular Biology Reports, 2022)

The Effects of Ground and Treadmill Running on Energy Metabolism and Muscle Contractile Properties: A Randomized Cross-Over Study - Yuan Zhou; Jian-gang Chen; Xiao-long Li; Xin-liang Pan; Yi-zheng Zhou; Zheng-ao Li; Zhi-cheng Liang; Jia-min Long; Ming-ze Qin; Jing Zhang; Bing Shi; Bing-jun Wan; et al. (Journal of Science in Sport and Exercise, 2022)
Purpose This study aimed to compare the effects of ground and treadmill running on energy metabolism and muscle contractile properties, providing a basis for the general public to choose running venues. Methods Ten male college students (age, 20.10 ± 1.53 years; height, 176.20 ± 5.49 cm; weight, 72.14 ± 8.25 kg; body fat percent, 12.41% ± 4.65%) were recruited in this study. Energy expenditure (EE) was measured using the accelerometer (GT9X) combined with specific estimation equations. Average heart rate (HR) was measured using a heart rate band (Polar). Muscle contractile properties were assessed by measuring muscle displacement (Dm) and contraction velocity (Vc) using tensiomyography (TMG-S1). Blood glucose (Glu) and lactate (Lac) were measured by portable devices (eB-G and Lactate Scout). The running speed was 9 km/h and the duration was 25 min. Two-way ANOVA (protocol × time) was used to analyze the effect of running protocols on energy metabolism and muscle contractile properties. Results EE of treadmill running was significantly higher than EE of ground running (protocol main effect, P < 0.001), and HR of treadmill running was significantly higher than that of ground running in the first testing time (protocol simple effect, P = 0.026; protocol × time interaction P = 0.043). The decrease in Dm of the rectus femoris after treadmill running was significantly higher than that of ground running (protocol main effect, P = 0.009). The interaction of different running protocols and testing times on Lac was significant ( P = 0.025), but all results of the simple effects analysis were not statistically significant ( P > 0.05). Conclusion Our study found a difference in energy expenditure between treadmill and ground running at 9 km/h with duration of 25 min. In addition, treadmills are more likely to cause a decrease in muscle displacement distance of the rectus femoris measured after exercise than ground running. Future studies are needed to further investigate whether the differences are induced by internal metabolism or the environmental conditions of running.

Environmental toxic metal contaminants and risk of stroke: a systematic review and meta-analysis - Qiang-Ji Bao; Kai Zhao; Yu Guo; Xin-Ting Wu; Jin-Cai Yang; Ming-Fei Yang (Environmental Science and Pollution Research, 2022)

Study on the seepage control of ultra-deep in situ test wells in deep overburden of riverbeds - Ting Yu; Bing-nan Jiang; Shun-bin He; Wen-ming Peng; Cong-yong Ran (Arabian Journal of Geosciences, 2022)

Metagenomic insights into the environmental adaptation and metabolism of Candidatus Haloplasmatales, one archaeal order thriving in saline lakes - Heng Zhou; Dahe Zhao; Shengjie Zhang; Qiong Xue; Manqi Zhang; Haiying Yu; Jian Zhou; Ming Li; Sumit Kumar; Hua Xiang (Environmental Microbiology, 2022)
Summary The KTK 4A‐related Thermoplasmata thrives in the sediment of saline lakes; however, systematic research on its taxonomy, environmental adaptation and metabolism is lacking. Here, we detected this abundant lineage in the sediment of five artificially separated ponds (salinity 7.0%–33.0%) within a Chinese soda‐saline lake using culture‐independent metagenomics and archaeal 16S rRNA gene amplicons. The phylogenies based on the 16S rRNA gene, and 122 archaeal ubiquitous single‐copy proteins and genome‐level identity analyses among the metagenome‐assembled genomes demonstrate this lineage forming a novel order, Candidatus Haloplasmatales, comprising four genera affiliated with the identical family. Isoelectric point profiles of predicted proteomes suggest that most members adopt the energetically favourable ‘salt‐in’ strategy. Functional prediction indicates the lithoheterotrophic nature with the versatile metabolic potentials for carbohydrate and organic acids as well as carbon monoxide and hydrogen utilization. Additionally, hydrogenase genes hdrABC ‐ mvhADG are linked with incomplete reductive citrate cycle genes in the genomes, suggesting their functional connection. Comparison with the coupling of HdrABC‐MvhADG and methanogenesis pathway provides new insights into the compatibility of laterally acquired methanogenesis with energy metabolism in the related order Methanomassiliicoccales . Globally, our research sheds light on the taxonomy, environmental adaptative mechanisms, metabolic potentials and evolutional significance of Ca . Haloplasmatales.

Quantifying effect of tassels on near-ground maize canopy RGB images using deep learning segmentation algorithm - Mingchao Shao; Chenwei Nie; Minghan Cheng; Xun Yu; Yi Bai; Bo Ming; Hongli Song; Xiuliang Jin (Precision Agriculture, 2022)

Anterior Cingulate Cortex Mediates Hyperalgesia and Anxiety Induced by Chronic Pancreatitis in Rats - Dan Ren; Jia-Ni Li; Xin-Tong Qiu; Fa-Ping Wan; Zhen-Yu Wu; Bo-Yuan Fan; Ming-Ming Zhang; Tao Chen; Hui Li; Yang Bai; Yun-Qing Li (Neuroscience Bulletin, 2022)
Central sensitization is essential in maintaining chronic pain induced by chronic pancreatitis (CP), but cortical modulation of painful CP remains elusive. Here, we examined the role of the anterior cingulate cortex (ACC) in the pathogenesis of abdominal hyperalgesia in a rat model of CP induced by intraductal administration of trinitrobenzene sulfonic acid (TNBS). TNBS treatment resulted in long-term abdominal hyperalgesia and anxiety in rats. Morphological data indicated that painful CP induced a significant increase in FOS-expressing neurons in the nucleus tractus solitarii (NTS) and ACC, and some FOS-expressing neurons in the NTS projected to the ACC. In addition, a larger portion of ascending fibers from the NTS innervated pyramidal neurons, the neural subpopulation primarily expressing FOS under the condition of painful CP, rather than GABAergic neurons within the ACC. CP rats showed increased expression of vesicular glutamate transporter 1, and increased membrane trafficking and phosphorylation of the N -methyl-D-aspartate receptor (NMDAR) subunit NR2B and the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) subunit GluR1 within the ACC. Microinjection of NMDAR and AMPAR antagonists into the ACC to block excitatory synaptic transmission significantly attenuated abdominal hyperalgesia in CP rats, which was similar to the analgesic effect of endomorphins injected into the ACC. Specifically inhibiting the excitability of ACC pyramidal cells via chemogenetics reduced both hyperalgesia and comorbid anxiety, whereas activating these neurons via optogenetics failed to aggravate hyperalgesia and anxiety in CP rats. Taken together, these findings provide neurocircuit, biochemical, and behavioral evidence for involvement of the ACC in hyperalgesia and anxiety in CP rats, as well as novel insights into the cortical modulation of painful CP, and highlights the ACC as a potential target for neuromodulatory interventions in the treatment of painful CP.