Association Between Regular Blood Pressure Monitoring and the Risk of Intracranial Aneurysm Rupture: a Multicenter Retrospective Study with Propensity Score Matching - Ping Zhong; Zhiwen Lu; Tianxiao Li; Qing Lan; Jianmin Liu; Zhanxiang Wang; Sifang Chen; Qinghai Huang (Translational Stroke Research, 2022)

Environmental impact of typical zinc smelting that implements solid waste collaborative utilization in China - Wei-Ning Liu; Yao Shi; Chen-Mu Zhang; Lang-Ming Liu; Hui-Quan Li; Bin Lu; Yuan-Bo Xie; Cai-Bei Zhuang; Tian-You Sun; Wei-Ping Liu; Xue Guan; Ying-Yan Hu (The International Journal of Life Cycle Assessment, 2022)

The landscape of aging - Yusheng Cai; Wei Song; Jiaming Li; Ying Jing; Chuqian Liang; Liyuan Zhang; Xia Zhang; Wenhui Zhang; Beibei Liu; Yongpan An; Jingyi Li; Baixue Tang; et al. (Science China Life Sciences, 2022)

Direct Tensile Test and FDEM Numerical Study on Anisotropic Tensile Strength of Kangding Slate - Ping Liu; Quansheng Liu; Xing Huang; Mingming Hu; Yin Bo; Dong Yuan; Xianqi Xie (Rock Mechanics and Rock Engineering, 2022)

Ten years of warming increased plant-derived carbon accumulation in an East Asian monsoon forest - Jing Zhang; Luhui Kuang; Zhijian Mou; Toshiaki Kondo; Jun Koarashi; Mariko Atarashi-Andoh; Yue Li; Xuli Tang; Ying-Ping Wang; Josep Peñuelas; Jordi Sardans; Dafeng Hui; et al. (Plant and Soil, 2022)

Combined analysis of mRNA and miRNA reveals the banana potassium absorption regulatory network and validation of miRNA160a - Wenliang Chen; Tao Dong; Yinglong Chen; Ping Lin; Chuqiao Wang; Kelin Chen; Yi Tang; Mingyuan Wang; Jianfu Liu; Hailing Yu (Plant Molecular Biology, 2022)

Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson’s Disease - Cheng-Jie Li; Li-Ge Zhang; Lu-Bing Liu; Meng-Qi An; Li-guo Dong; Han-Ying Gu; Yong-Ping Dai; Fen Wang; Cheng-Jie Mao; Chun-Feng Liu (Molecular Neurobiology, 2022)

Hepatic HRC induces hepatocyte pyroptosis and HSCs activation via NLRP3/caspase-1 pathway - Jingwen Wu; Mingyu Zhang; Suhong Xia; Ping Han; Kai Zhao; Kaixin Peng; Wangdong Zhou; Dean Tian; Jiazhi Liao; Jingmei Liu (Journal of Molecular Medicine, 2022)

Inhibition of Microglial NLRP3 with MCC950 Attenuates Microglial Morphology and NLRP3/Caspase-1/IL-1β Signaling In Stress-induced Mice - Qing Liu; Man-Man Zhang; Min-Xia Guo; Qiu-Ping Zhang; Na-Zhi Li; Jie Cheng; Shi-Le Wang; Guang-Hui Xu; Cheng-Fu Li; Ji-Xiao Zhu; Li-Tao Yi (Journal of Neuroimmune Pharmacology, 2022)

Modulating the Gut Microbiota as a Therapeutic Intervention for Alzheimer’s Disease - Mingli Liu; Ping Zhong (Indian Journal of Microbiology, 2022)

Resistivity is used as a tool to evaluate the variability of soil water content - Bin Zhang; Mao-sheng Zhang; Ping-ping Sun; Hao Liu; Li Feng (Journal of Mountain Science, 2022)

A water-soluble polysaccharide from Eucommia folium: the structural characterization and anti-tumor activity in vivo - Zhi-Qian Yan; Su-Yun Ding; Pei Chen; Hui-Ping Liu; Meng-Li Chang; Shu-Yuan Shi (Glycoconjugate Journal, 2022)

The value of social media tool for monitoring and evaluating environment policy communication: a case study of the ‘Zero-waste City’ initiative in China - Ping Gong; Li Wang; Xiaolong Liu; Yigang Wei (Energy, Ecology and Environment, 2022)

Characterization of a novel victorivirus from Nigrospora chinensis, a fungus isolated from tobacco - Jie Zhong; Wen Wen Sui; Ping Li; Qian Jun Tang; Tian Bo Liu; Yan Song Xiao (Archives of Virology, 2022)

p21-activated kinase 1 (PAK1) as a therapeutic target for cardiotoxicity - Ping Guo; Yufeng Liu; Jingrong Feng; Shihang Tang; Fanyan Wei; Jian Feng (Archives of Toxicology, 2022)

Profiling of bacterial transcriptome from ultra‐low input with MiniBac ‐seq - Tianmin Wang; Ping Shen; Ruochen Chai; Yihui He; Jintao Liu (Environmental Microbiology, 2022)
There is a lack of appropriate methods for preparing bacterial RNA‐seq library with ultra‐low amount of RNA. To address this issue, we developed miniBac‐seq, a strand‐specific method for high‐quality library construction from sub‐nanogram of total RNA, which is 100‐fold lower than the current benchmark kit and dramatically reduces preparation cost ($28 + $15 × samples). We further demonstrated the high sensitivity of miniBac‐seq via detecting more than 500 genes from amount of total RNA equivalent to that of a single bacterial cell. Finally, we profiled the transcriptome of growth‐arrested bacteria in isogenic culture of Escherichia coli . This subpopulation of bacteria is generally low in abundance but is a potent reservoir of antibiotic persistence, and their gene expression has been largely unknown due to technical limitations. Using miniBac‐seq, we identified potential molecular driver towards arrested growth as well as antibiotic tolerance. Our method thus expands the capacity to quantify bacterial transcriptome in situ, which is useful to the understanding of bacterial physiology and regulation in their native contexts.

Derivation of new resistance principle on flow-induced morphological response of flexible vegetation - Feng-Cong Jia; Wei-Jie Wang; Ling-Hua Liu; Jin-Jin Li; Ai-Ping Huang; Jing Zhang; Yi-Cheng Fu; Yang Yu (Environmental Science and Pollution Research, 2022)

Synergistic impacts of westerlies and monsoon on interdecadal variations of late spring precipitation over the southeastern extension of the Tibetan Plateau - Jing Wang; Yanju Liu; Chengyu Song; Yihui Ding; Qiaoping Li; Ping Wu; Ying Xu; Xiangde Xu (International Journal of Climatology, 2022)
Based on multiple long‐term observational and reanalysis datasets, this study investigated the characteristics and physical mechanisms of the interdecadal variations in late spring (i.e., May) precipitation (LSP) over the southeastern extension of the Tibetan Plateau (SETP) since 1900. It was revealed that by and large, LSP over the SETP experienced interdecadal decrease during the period preceding 1927, 1962–1988, and 2004 onwards, but saw an increase during the periods of 1928–1961 and 1989–2003. The atmospheric circulations responsible for interdecadal variations in LSP over the SETP were also analysed. These analyses identified significant synergistic impacts of decreased mid‐latitude upstream westerlies and increased low‐latitude monsoonal southerlies over the Central North Bay of Bengal (CNBOB) on interdecadal variations in precipitation, suggesting striking interactions between extratropical eastward cold air and tropical northward warm/humid air. Further observational and modelling evidence suggested that Atlantic Multidecadal Oscillation (AMO) was likely to be a salient oceanic driver for the interdecadal synergy between upstream westerlies and CNBOB monsoonal southerlies. The elevated sea surface temperature anomalies associated with the warm phase of the AMO could spark favourable local atmospheric anomalies, forcing an upper‐tropospheric, planetary‐scale teleconnection emanating from the east of the North Atlantic sector, which may serve as an effective bridge linking the remote AMO signal and the synergy between westerlies and monsoonal southerlies around the SETP on interdecadal timescales. Our findings provided new insights into the understanding of the synergistic roles of westerlies and monsoons in the modulation of interdecadal LSP over the SETP, prior to the peak Asian summer monsoon season.

Typhoon-Resistant Performance Assessment of Coastal Rural Residential Keel Brick Walls Reinforced with High Ductility Concrete - Qiang Li; Jun Zhang; Rui Wang; Jing Liu; Ping Li (Journal of Marine Science and Engineering, 2022)
The keel brick wall belongs to the rural residential exterior wall unique to the southeast coastal region of China. The wooden keel inside the wall and the external tie members can improve the stability of the whole wall. However, due to the age of construction, the wooden keel inside the existing residential keel brick walls has basically rotted and lost the tie with the external members, which seriously reduces the stability of the whole wall. Moreover, the collapse of keel brick walls caused by typhoons has become more and more frequent in recent years, seriously endangering the lives and properties of residents. Therefore, it is necessary to carry out reinforcement and repair for the existing residential buildings with keel brick walls. In this paper, the keel brick walls of rural houses in Ningbo area were taken as the research object, a framework for evaluating the performance of keel brick walls against typhoons was established, tests on the lateral force resistance of keel brick walls reinforced with high ductility concrete and mortar were carried out. With the help of typhoon full-track simulation and wind field simulation technology, the 600-year near-surface typhoon wind speeds affecting Ningbo area were obtained. A joint probability distribution model of multi-directional extreme wind speed was constructed using t-Copula function to determine the mixed wind climate of Ningbo area. The extreme wind loads that keel brick walls can withstand under four types of reinforcement were finally given. The results show that the high ductility concrete reinforcement has great advantages over mortar reinforcement and avoids brittle damage of the masonry structure. The keel brick walls reinforced with single-sided mortar can withstand wind loads of a 3-year return period, the keel brick walls reinforced with single-sided high ductile concrete can withstand extreme wind loads of a 110-year return period, while the keel brick walls reinforced with double-sided mortar as well as double-sided high ductile concrete can withstand extreme wind loads of well over a 110-year return period.

Simultaneous trace determination of three natural estrogens and their sulfate and glucuronide conjugates in municipal waste and river water samples with UPLC-MS/MS - Qing-guang Ma; Yi-ping Wan; Ze-hua Liu; Zhi Dang (Environmental Science and Pollution Research, 2022)

An Energy Efficiency Optimization Strategy of Hybrid Electric Ship Based on Working Condition Prediction - Beibei Liu; Diju Gao; Ping Yang; Yihuai Hu (Journal of Marine Science and Engineering, 2022)
Optimizing the operational performance of green ships can further improve the energy saving and emission reduction effect of ships, and speed optimization is one of the more widely used and effective measures. It is a new challenge for the shipping industry to achieve speed optimization that simultaneously saves energy, reduces emissions and meets transportation requirements, while considering changes in the navigation environment. In this paper, a hybrid electric ship energy efficiency optimization strategy based on working condition prediction is proposed to solve the problem of navigation condition at a future moment, by making a time series prediction of energy efficiency influencing factors, such as wind speed and current speed. Further, on the basis of establishing the sailing speed prediction model and the real-time energy efficiency operation index (EEOI) model, the real-time EEOI deviation and the sailing speed deviation are adopted as the comprehensive objective function to establish a dynamic optimization model of hybrid electric ship energy efficiency, considering the time-varying environmental factors. Then, the fast Non-Dominated Sorting Genetic Algorithm II (NSGA-II) is applied to solve the bi-objective optimization problem and obtain the optimal ship engine speed in real time. Finally, experimental studies show that the proposed optimization model can improve the energy-saving and emission-reduction effect of the ship under the given speed limit requirements and working environment conditions, which can provide theoretical support for the optimal navigation of hybrid electric ships.

Physiological responses of marine Chlorella sp. exposed to environmental levels of triphenyltin - Zhihan Cao; Ping Li; Jinchuang Ru; Xuqian Cao; Xu Wang; Bin Liu; Zhi-Hua Li (Environmental Science and Pollution Research, 2022)

The effect of reservoir expansion from underground karst cave to surface reservoir on water quality in southwestern China - Meng Lu; Xiao-Dan Wang; Fu-Jun Yue; Zi-Han Liu; Zhi-Yu Shi; Ping Zhang (Environmental Science and Pollution Research, 2022)

Two new sesquiterpenoid lactone derivatives from Lindera aggregata - Song-Song Wen; Yan Wang; Jia-Ping Xu; Qi Liu; Lei Zhang; Jing Zheng; Lin Li; Na Zhang; Xin Liu; Yu-Wen Xu; Zhen-Liang Sun (Natural Product Research, 2022)

Receipt of inactivated COVID-19 vaccine had no adverse influence on embryo implantation, clinical pregnancy and miscarriage in early pregnancy - Yapeng Wang; Xiulian Ren; Zhongwei Wang; Xue Feng; Ming Li; Ping Liu (Science China Life Sciences, 2022)

Ginsenoside Rb1 inhibits oxidative stress-induced ovarian granulosa cell injury through Akt-FoxO1 interaction - Ping Zhou; Feng Deng; Zi Yang; Canhui Cao; Hongcui Zhao; Fenting Liu; Ke Zhong; Lin Fu; Tianliu Peng; Di Sun; Hui Liu; Rong Li; et al. (Science China Life Sciences, 2022)

Failure and Instability Characteristics of Coal-Rock Parting-Coal Structures with Rough Discontinuities - Yang Liu; Cai-Ping Lu; Xiu-Feng Zhang; Ying Guo; Chun-Hui Song; Chao Wang (Rock Mechanics and Rock Engineering, 2022)

Larval midgut protease activity of Illiberis pruni (Lepidoptera: Zygaenidae) feeding on multiple characteristic hosts - Dongbiao Lv; Xueying Liu; Yanlu Dong; Zizheng Yan; Xuan Zhang; Jingyi Ren; Ping Wang; Yiping Li (Phytoparasitica, 2022)

A1 Adenosine Receptor Activation Inhibits P2X3 Receptor–Mediated ATP Currents in Rat Dorsal Root Ganglion Neurons - Jia-Wei Hao; Wen-Long Qiao; Qing Li; Shuang Wei; Xue-Mei Li; Ting-Ting Liu; Chun-Yu Qiu; Wang-Ping Hu (Molecular Neurobiology, 2022)

Increased expression of Myosin X contributes to the metastasis in patients with laryngeal squamous cell carcinoma - Gang Deng; Tie-Jun Fu; Cui-Ping Liu (Molecular Genetics and Genomics, 2022)
Laryngeal Squamous Cell Carcinoma (LSCC) is one of the most common malignancy in Head and neck cancer for which the mechanism underlying its metastasis is poorly understood. Myosin X, a molecular motor in cells has been demonstrated to play an important role in cell migration. However, whether Myosin X is involved in the metastasis of LSCC remains unclear. To investigate the expression of Myosin X and its implication in the metastasis of LSCC, we recruited 30 patients with LSCC and 6 patients with vocal cord polyp range from October 2016 to October 2018. Tissue samples were obtained during surgery and the expression of Myosin X, Cortactin, MMP2, MMP9, E-cadherin, and β-catenin in tissue samples were evaluated by RT-PCR, Western blot, immunohistochemistry or ELISA. Patients with LSCC were further followed-up 2 year after surgery for metastasis analysis. We found that the level of Myosin X, Cortactin, MMP2, and MMP9 was much higher in poorly differentiated LSCC compared to that in moderately and highly LSCC, as well as the control tissues. In contrast, the expression of epithelial-mesenchymal transition related marker, E-cadherin, and β-catenin, were much lower in poorly differentiated LSCC tissues compared to that in moderately and highly differentiated LSCC tissues, as well as the control tissues. Moreover, the expression of Myosin X was positively correlated with Cortactin, MMP2, and MMP9 levels. Increased expression of Myosin X in LSCC tissues was related to higher risk of metastasis. In conclusion, our findings showed that. Myosin X augments the expression of Cortactin, MMP2 and MMP9, which could upregulate the cell migration and the matrix degradation, and consequently reduce the expression of E-cadherin and β-catenin, thereby activating epithelial-mesenchymal transformation and promoting the metastasis of LSCC. Targeting Myosin X may have potential therapeutic effect in the metastasis of LSCC.

Application of regional citrate anticoagulation in patients at high risk of bleeding during intermittent hemodialysis: a prospective multicenter randomized controlled trial - Xiaoyan Tang; Dezheng Chen; Ling Zhang; Ping Fu; Yanxia Chen; Zhou Xiao; Xiangcheng Xiao; Weisheng Peng; Li Cheng; Yanmin Zhang; Hongbo Li; Kehui Li; et al. (Journal of Zhejiang University-SCIENCE B, 2022)

Genetic diversity, lineage divergence, and demography of Diaphanosoma dubium (Crustacea: Cladocera) on Hainan Island, China - Ping Liu; Xiaoli Zhang; Qi Huang; Eric Zeus C. Rizo; Henri J. Dumont; Bo-Ping Han (Hydrobiologia, 2022)

Is Oxalic Acid Secretion A Detoxification Strategy for Rice Exposed to Tl(I) or Tl(III)? - Yan Yao; Ruiqi Yang; Wenqin Liao; Yuqi Wang; Wei Liu; Xuexia Huang; Xiaolan Wang; Ping Zhang (Bulletin of Environmental Contamination and Toxicology, 2022)

Adaptive Proportional-Integral Sliding Mode-Based Fault Tolerant Control for Autonomous Underwater Vehicles with Thrusters Saturation and Potential Failure - Jian Xu; Xing Wang; Ping Liu; Qiaoyu Duan (Journal of Marine Science and Engineering, 2022)
This paper focuses on the fault tolerant control of autonomous underwater vehicles (AUVs) in the presence of dynamic uncertainties and potential thruster failure issues. For this, an adaptive proportional-integral sliding mode-based fault tolerant control (APISM-FTC) is proposed to drive the AUV to follow the desired trajectory, in the event of unknown thrusters failure and thrusters saturation. Radial basis function neural network (RBFNN) and an adaptive approach are used to evaluate the dynamics uncertainty during the construction of the APISM-FTC controller. To guarantee that all tracking errors asymptotically converge to zero, a comprehensive theoretical analysis and mathematical proof based on Lyapunov stability analysis are implemented. The simulation experiments on two fault conditions are carried out, respectively, and the control effects under normal conditions are compared. It can be shown that the designed APISM-FTC method can make the system reach a stable state quickly, and can still have a good control performance in the case of the failure of the thruster.

Dynamic mechanical properties and constitutive model for jointed mudstone samples subjected to cyclic loading - Di Yu; Enlong Liu; Ping Sun; Huilin Xing; Qingsong Zheng (European Journal of Environmental and Civil Engineering, 2022)

Dissolved oxygen gradient on three dimensionally printed microfluidic platform for studying its effect on fish at three levels: cell, embryo, and larva - Ping Liu; Longwen Fu; Bowei Li; Mingsan Man; Yunxia Ji; Qi Kang; Xiyan Sun; Dazhong Shen; Lingxin Chen (Environmental Science and Pollution Research, 2022)

Metabolomic analysis reveals the impact of ketoprofen on carbon and nitrogen metabolism in rice (Oryza sativa L.) seedling leaves - Huan Wang; Zhiheng Li; Hanmei Chen; Jiaojun Jin; Ping Zhang; Luoqin Shen; Shuhao Hu; Huijun Liu (Environmental Science and Pollution Research, 2022)

Monoterpenoid indole alkaloids with potential neuroprotective activities from the stems and leaves of Melodinus cochinchinensis - Yu-Jie Li; Juan Li; Lan Xie; Jun-Yu Zhou; Qiu-Xuan Li; Rui-Yuan Yang; Yan-Ping Liu; Yan-Hui Fu (Natural Product Research, 2022)

EST-SSR marker-based investigation on genetic diversity and genetic structure of Juglans mandshurica Maxim. in Shandong Province of China - Zihao Wang; Hao Zhang; Boqiang Tong; Biao Han; Dan Liu; Ping Zhang; Dechang Hu (Genetic Resources and Crop Evolution, 2022)

Correction to: NMR technique revealed the metabolic interference mechanism of the combined exposure to cadmium and tributyltin in grass carp larvae - Shuwen He; Ping Li; Ling Liu; Zhi-Hua Li (Environmental Science and Pollution Research, 2022)

Comparative transcriptome analysis of Portunus trituberculatus in response to Vibrio parahaemolyticus and low salinity - Yukun Li; Jianjian Lv; Jie Wu; Ping Liu; Baoquan Gao (Frontiers in Marine Science, 2022)
Vibrio parahaemolyticus is a common pathogen of marine crustaceans and is responsible for large losses in aquaculture. Salinity is an important environmental factor, and abrupt changes in salinity can affect the immunity of crustaceans. In this study, we carried out a transcriptomic analysis under pathogenic infection and low salt stress, and conducted a comparative analysis of the differentially expressed genes (DEGs) after stimulation by the two factors. Illumina sequencing technology was used for the transcriptome sequencing of 27 hepatopancreas samples, and 178.77 G sequencing data and an average of 44,142,119 clean reads per sample were obtained. A total of 3,047 and 3,710 DEGs were found after V. parahaemolyticus infection and low salt stress, which included a number of innate immunity genes, such as Toll-like receptor (TLR), anti-lipopolysaccharide factor (ALF), lectin, and hemocyanin. In addition, 2,016 common DEGs were found, accounting for 42.52% of the total DEGs. Among these, 169 DEGs were up-regulated after pathogenic infection and down-regulated after low salt stress, and were mainly enriched in starch and sucrose metabolism, nitrogen metabolism, amino sugar and nucleotide sugar processes, and other pathways. Collectively, these results provide data support for the analysis of the immune mechanism of crabs against V. parahaemolyticus and will also help to clarify the molecular mechanism by which salinity affects immunity.

Comparative transcriptomic analysis and validation of the ovary and testis in the ridgetail white prawn (Exopalaemon carinicauda) - Shaoting Jia; Ling Jin; Jianjian Lv; Jiajia Wang; Jitao Li; Ping Liu; Jian Li (Frontiers in Marine Science, 2022)
The ridgetail white prawn, Exopalaemon carinicauda is an important cultured seawater species in China. As female E.carinicauda grows faster than males, it is significant to search for the differentially expressed genes (DEGs) between males and females. However, there is no public available E.carinicauda genome data, and genes related to E. carinicauda sex differences are unclear. In this study, the transcriptome sequencing for ovary and testis tissues of E. carinicauda were conducted, and 20,891 DEGs were identified including 11,709 up-regulated DEGs and 9,182 downregulated DEGs. The functional categories related to meiosis and reproduction were enriched as well as the steroidogenesis KEGG pathway was clustered. Furthermore, the genes related to male reproduction and cell cycle were dug out which were verified by real-time PCR. In addition, two-color fluorescent in situ hybridization result showed that foxj1b might play roles during early stage of the ovary development. Therefore, our result provides clues for the study of genes related to reproduction and sex difference in E.carinicauda .

NMR technique revealed the metabolic interference mechanism of the combined exposure to cadmium and tributyltin in grass carp larvae - Shuwen He; Ping Li; Ling Liu; Zhi-Hua Li (Environmental Science and Pollution Research, 2022)

Four new secoiridoids from the stem barks of Syringa reticulata (Bl.) Hara - Shuang Guo; Yan Liu; Yan-Ping Sun; Juan Pan; Wei Guan; Xiao-Mao Li; Si-Yi Wang; Adnan Mohammed Algradi; Bing-You Yang; Hai-Xue Kuang (Natural Product Research, 2022)

Stem Cell-Derived Exosomes: A New Method for Reversing Skin Aging - Jin-Yan Wu; Sai-Nan Wu; Li-Ping Zhang; Xian-Sheng Zhao; Yue Li; Qu-Yang Yang; Ruo-Yue Yuan; Jian-Lan Liu; Hong-Ju Mao; Ning-Wen Zhu (Tissue Engineering and Regenerative Medicine, 2022)

Integrated genetic mapping and transcriptome analysis reveal the BnaA03.IAA7 protein regulates plant architecture and gibberellin signaling in Brassica napus L. - Xiaoke Ping; Qianjun Ye; Mei Yan; Jianyan Zeng; Xingying Yan; Haitao Li; Jiana Li; Liezhao Liu (Theoretical and Applied Genetics, 2022)

Toward in Vitro Production of Platelet from Induced Pluripotent Stem Cells - Elaheh Izady; Zohreh Saltanatpour; Li-Ping Liu; Akram Alizadeh; Amir Ali Hamidieh (Stem Cell Reviews and Reports, 2022)

Improving pre-harvest sprouting resistance in rice by editing OsABA8ox using CRISPR/Cas9 - Kai Fu; Weihan Song; Cheng Chen; Changling Mou; Yunshuai Huang; Fulin Zhang; Qixian Hao; Ping Wang; Tengfei Ma; Yaping Chen; Ziyan Zhu; Min Zhang; et al. (Plant Cell Reports, 2022)

Enhanced M-CSF/CSF1R Signaling Closely Associates with PrPSc Accumulation in the Scrapie-Infected Cell Line and the Brains of Scrapie-Infected Experimental Rodents - Ying Xia; Cao Chen; Jia Chen; Chao Hu; Wei Yang; Lin Wang; Lian Liu; Li-Ping Gao; Yue-Zhang Wu; Dong-Dong Chen; Qi Shi; Zhi-Bao Chen; et al. (Molecular Neurobiology, 2022)

Genome-Wide Bisulphite Sequencing Uncovered the Contribution of DNA Methylation to Rice Short-Term Drought Memory Formation - Shuyan Kou; Qiongyao Gu; Liu Duan; Gaojing Liu; Pingrong Yuan; Huahui Li; Zhigang Wu; Weihua Liu; Ping Huang; Li Liu (Journal of Plant Growth Regulation, 2022)
Rice is the important crop for more than half of the world population. However, drought can have a devastating impact on rice growth and reduce yield drastically. Understanding the response of rice to drought stress is especially important for crop breeding. Previously we found that rice enhanced its tolerance to drought stresses via stress memory mechanisms. Numerous memory genes were identified to play important roles in the process. DNA methylation was reported to mediate tolerance via regulating gene expression and enhances the survival rate of rice encountering drought stress. However, how DNA methylation involved in stress memory is still not clear. In this study, genome-wide bisulphite sequencing at a single base resolution methylome profiling level was performed and analyzed in rice cultivar under recurrent drought stresses and recovery treatments. We found that rice drought stress memory-related differentially methylated regions (DMRs) showed dynamic and distinct patterns. The drought-memory DMRs may regulate Transposable elements and gene expression to cope with short-term repeated drought stresses. Our findings of drought-memory DMRs can explain mechanisms of rice drought stress memory in a new perspective on global methylome details. Using epigenetic markers to breed drought-resistant rice would become a feasible way in the future research.

TGF-β1/Smad3 upregulates UCA1 to promote liver fibrosis through DKK1 and miR18a - Zhangshuo Yang; Hao Zhang; Maohui Yin; Zhixiang Cheng; Ping Jiang; Maohui Feng; Zhisu Liu; Bo Liao (Journal of Molecular Medicine, 2022)

Comparative transcriptome analyses identify genes involved into the biosynthesis of forsythin and forsythoside A in Forsythia suspensa - Wang Jun Yuan; Su Ping Zhang; Zhi Yin He; Yan Xia He; She Qi He; Li Jun Liu; Xin Sun; Qin Li (Functional & Integrative Genomics, 2022)

Effect of posaconazole on the concentration of intravenous and oral cyclosporine in patients undergoing hematopoietic stem cell transplantation - Li-E Zhu; Hui-Ping Huang; Yi-Peng Cai; Yan Wang; Bao-Hua Xu; Mao-Bai Liu; Xue-Mei Wu (European Journal of Clinical Pharmacology, 2022)

Sulfur fertiliser enhancement of Erigeron breviscapus (Asteraceae) quality by improving plant physiological responses and reducing soil cadmium bioavailability - Yonglin Liu; Yingpin Liu; Yu Chen; Ping Zhao; Shengchao Yang; Shuran He; Guangqiang Long (Environmental Science and Pollution Research, 2022)

Circ_0006404 enhances hepatocellular carcinoma progression by regulating miR-624 - Liguo Zhang; Ping Zhang; Tonggang Liu; Dongmei Li; Xianxian Liu (Environmental Science and Pollution Research, 2022)

Oceanobacillus saliphilus sp. nov., Isolated from Saline−Alkali Soil in Heilongjiang Province, China - Yu-Ting OuYang; Meng-Meng Li; Ai-Ping Lv; Pin-Jiao Jin; Lan Liu; Ze-Tao Liu; Jian-Yu Jiao; Wen-Jun Li; Li-Xiang Cao; Shuang Wang (Current Microbiology, 2022)

The eastward expansion of the climate humidification trend in northwest China and the synergistic influences on the circulation mechanism - Qiang Zhang; Jinhu Yang; Xinyu Duan; Pengli Ma; Guoyang Lu; Biao Zhu; Xiaoyun Liu; Ping Yue; Youheng Wang; Weiping Liu (Climate Dynamics, 2022)

Nuclear magnetic resonance analysis of the failure and damage model of rock masses during freeze‒thaw cycles - Taoying Liu; Mengyuan Cui; Chaoyang Zhang; Keping Zhou; Wenchao Shi; Ping Cao (Bulletin of Engineering Geology and the Environment, 2022)

Composition, Source and Environmental Indication of Clay Minerals in Sediments from Mud Deposits in he Southern Weihai Offshore, Northwestern Shelf of the South Yellow Sea, China - Jinqing Liu; Yilin Liu; Ping Yin; Fei Gao; Ke Cao; Xiaoying Chen (Journal of Ocean University of China, 2022)

Streptomyces pimonensis sp. nov., isolated from the Taklimakan desert in Xinjiang, China - Ping Zhang; Xiaoxia Luo; Xinrong Luo; Zhanwen Liu; Zhanfeng Xia; Chuanxing Wan; Lili Zhang (Archives of Microbiology, 2022)

Streptomyces akebiae sp. nov., a novel actinomycete isolated from rhizosphere soil of Akebia trifoliate - Ping Mo; Kaiqin Li; Jinhua Zhou; Fumin Zhou; Yazhi Chen; Xiaojia Lin; Xiaoyu Liu; Kerui Huang; Wansheng Zou; Jian Gao (Antonie van Leeuwenhoek, 2022)

Proteomic Analysis Associated with the Immune Response in Hemocytes of Portunus trituberculatus Challenged with Vibrio parahaemolyticus - Baoquan Gao; Xianyun Ren; Jianjian Lv; Xianliang Meng; Ping Liu; Jian Li (Fishes, 2022)
Vibrio parahaemolyticus belongs to an expanding group of aquatic pathogens that are widely distributed in aquatic environments. This species is a lethal pathogen for a number of economically important marine crabs. However, studies exploring host–vibrio interactions between V. parahaemolyticus and crabs are scarce, and therefore, the underlying molecular mechanisms are unclear. Herein, we performed a comprehensive proteomic analysis to investigate the immune response of Portunus trituberculatus hemocytes to V. parahaemolyticus infection. A total of 4433 proteins were identified using isobaric tags for relative and absolute quantitation (iTRAQ), and 526 differentially expressed proteins (DEPs) were subjected to Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis, with six DEPs further subjected to quantitative real-time PCR. Several identified DEPs were found to be mainly involved in the immune defense of the crustacean, such as a hemocyanin subunit, C-type lectin, α-2-macroglobulin, Cu/Zn-superoxide dismutase, and heat shock protein 70, playing a key role in the response to V. parahaemolyticus infection. Moreover, many immune-related KEGG pathways were markedly altered, such as cell adhesion molecules, complement and coagulation cascades, and phagosomes. Our results provide insights into how V. parahaemolyticus overcomes the innate immunity of P. trituberculatus to induce pathological alterations in affected tissues. We report the first iTRAQ-based proteomic analysis and highlight the key pathways and proteins involved in the host–vibrio interactions between P. trituberculatus and V. parahaemolyticus. These findings should enhance our understanding of the molecular mechanisms underlying such interactions.

Functional analysis of HADH c.99C>G shows that the variant causes the proliferation of pancreatic islets and leu-sensitive hyperinsulinaemia - Wu Long; Yue-Bing Wang; Peng-Fei Qu; Lin Ma; Si-Jie Wei; Yan-Mei Xi; Jin-Liang Du; Xue Tang; Kai Liu; Yu-Hua Li; Pu-Ping Lei (Journal of Genetics, 2022)

Sea ice recognition for CFOSAT SWIM at multiple small incidence angles in the Arctic - Meijie Liu; Ran Yan; Xi Zhang; Ying Xu; Ping Chen; Yongsen Zhao; Yuexiang Guo; Yangeng Chen; Xiaohan Zhang; Shengxu Li (Frontiers in Marine Science, 2022)
Sea ice recognition is one of the main tasks for sea ice monitoring in the Arctic and is also applied for the detection of other ocean phenomena. The Surface Wave Investigation and Monitoring (SWIM) instrument, as an innovative remote sensor that operates at multiple small incidence angles, is different from existing sensors with moderate and normal incidence modes for sea ice monitoring. Sea ice recognition at small incidence angles has rarely been studied. Moreover, SWIM uses a discrimination flag of sea ice and sea water to remove sea ice from sea wave products. Therefore, this research focuses on sea ice recognition in the Arctic based on SWIM data from October 2020 to April 2021. Eleven features are first extracted, and applied for the analysis of the waveform characteristics using the cumulative probability distribution (CPD) and mutual information measurement (MIM). Then, random forest (RF), k-nearest neighbor (KNN) and support vector machine (SVM) classifiers are built, and their abilities of sea ice recognition are assessed. The optimal classifier is the KNN method with Euclidean distance and k equal to 11. Feature combinations are also used to separate sea ice and sea water based on the KNN method to select the optimal combination. Thus, the optimal classifier-feature assembly at each small incidence angle is established, and the highest overall accuracy reaches 97.1%. Moreover, the application of the optimal classifier–feature assemblies is studied, and its performance is fairly good. These assemblies yield high accuracies in the short- and long-term periods of sea ice recognition, and the overall accuracies are greater than 93.1%. So, the proposed method satisfies the SWIM requirement of removing the sea ice effect. Moreover, sea ice extents and edges can be extracted from SWIM sea ice recognition results at a high level of precision greater than 94.8%. As a result, the optimal classifier–feature assemblies based on SWIM data express the effectiveness of the SWIM approach in sea ice recognition. Our work not only highlights the new sea ice monitoring technology of remote sensing at small incidence angles, but also studies the application of SWIM data in sea ice services.

Evaluating the performance of hydrological models with joint multifractal spectra - Zhixu Bai; Yue-Ping Xu; Suli Pan; Li Liu; Zixia Wang (Hydrological Sciences Journal, 2022)

Responses of tidal duration asymmetry to morphological changes in Lingding Bay of the Pearl River Estuary - Qingshu Yang; Shuai Hu; Linxi Fu; Ping Zhang; Nanyang Chu; Feng Liu; Huayang Cai (Frontiers in Marine Science, 2022)
Tidal asymmetry is one of the main factors for generating net transport for waterborne materials in tidal estuaries, and thus, this phenomenon has significant influences on controlling morphological development and the ecological environment. Tidal propagation is sensitive to changes in the coastline and geometry of estuarine regions. Moreover, tidal waveforms vary with various factors, such as coastline changes and bathymetry evolution due to local anthropogenic activities. The topography of Lingding Bay (LDB) of the Pearl River Estuary (PRE) has greatly changed since the 1960s because of human interventions, but the response of tidal duration asymmetry (TDA) to morphological changes is still poorly understood. Utilizing the two-dimensional Delft-3D flexible mesh numerical model, the spatial pattern of TDA and its primary contributors in LDB of the PRE were reproduced for 1964, 1989, and 2016, accounting for the changes in both shoreline and bathymetry owing to human interventions. The results reveal that as the tidal wave propagates upstream, the tidal skewness increases from negative values to positive values longitudinally, indicating the transition from a shorter ebb-duration state to a shorter flood-duration state. Additionally, a prominent shift in TDA and its primary contributors takes place approximately in the period of 1989. In 1964-1989, the tidal skewness increased by at least 0.1 throughout the LDB, indicating that the flood duration of the entire bay was shortened significantly. However, in 1989-2016, the tidal skewness decreased by at most 0.15 throughout the LDB, representing a longer flood duration in the entire LDB. The scenario simulations reveal that reclamation-induced shoreline changes control the increase in TDA and its primary contributors by enhancing width convergence of estuary in the period of 1964-1989. Conversely, the increase in water depth plays a vital role in the decrease of TDA in the period of 1989-2016. The results obtained from this study are particularly useful for understanding the controlled factors contributing to net sediment transport and the associated long-term morphological evolution in estuaries heavily impacted by human interventions.

Exploring the R-ISS stage-specific regular networks in the progression of multiple myeloma at single-cell resolution - Ling Zhong; Xiao Yang; Yu Zhou; Jialing Xiao; Huan Li; Jiang Tao; Qian Xi; Chen Chu; Chenglong Li; Xi Yang; Chen Yang; Yi Zhang; et al. (Science China Life Sciences, 2022)

Genetic Control of the Root System Traits in Oilseed Rape Under Contrasting Phosphate Supply Conditions by Genome-wide Association Study - Ping Xu; Xiaohua Wang; Hui Li; Shengjie Dai; Xue Cao; Zhenning Liu (Plant Molecular Biology Reporter, 2022)

Feasibility Studies of Nebulized SARS-CoV-2 Neutralizing Antibody in Mice and Cynomolgus Monkeys - Jilei Jia; Zhaojuan Yin; Xiao Zhang; Huimin Li; Dan Meng; Qianqian Liu; Hongfang Wang; Meng Han; Shixiang Suo; Yan Liu; Ping Hu; Chunyun Sun; et al. (Pharmaceutical Research, 2022)
Purpose Neutralizing antibodies, administrated through intravenous infusion, have shown to be highly efficacious in treating mild and moderate COVID-19 caused by SARS-CoV-2 infection in the lung. However, antibodies do not transport across the plasma-lung barrier efficiently, and up to 100 mg/kg dose was used in human causing significant supply and cost burdens. This study was to explore the feasibility of nebulized antibodies inhalation delivery as an alternative route. Methods HB27, a potent RBD-specific humanized monoclonal antibody (Zhu et al. in National Sci Rev. 8:nwaa297, 2020), showed excellent protection against SARS-CoV-2 in animal model and good safety profile in clinical studies. The pharmacokinetics and preliminary safety of HB27 administrated through the respiratory tract were studied in mice and cynomolgus monkeys here. Results At a single 5 mg/kg dose, the peak HB27 concentration in mice pulmonary epithelial lining fluid (ELF) reached 857.8 μg/mL, 670-fold higher than the PRNT 90 value of 1.28 μg/mL, and maintained above PRNT 90 over 240 h. In contrast, when administrated by intravenous injection at a 5 mg/kg dose, the antibody concentrations in mice ELF were below PRNT 90 value throughout, and were about 50-fold lower than that in the serum. In cynomolgus monkeys administrated with a single dose through inhalation, the antibody concentration in ELF remained high within 3 days. No drug-related safety concerns were observed in the studies. Conclusions The study demonstrated that nebulized neutralizing antibody delivery though inhalation could be a more efficient and efficacious alternative approach for treating COVID-19 and other respiratory infectious diseases, and warrants further evaluation in clinical studies.

Phylogeny and species diversity in Hygrophorus section Aurei in China - Hong-Yan Huang; Wen-Hao Zhang; Ting Huang; Gabriel Moreno; Yun-Ju Pu; Yu-Guang Fan; Shu-Da Yang; Tie-Zhi Liu; Li-Ping Tang (Mycological Progress, 2022)

Bio-organic Fertilizer with Bacillus subtilis F2 Promotes Strawberry Plant Growth and Changes Rhizosphere Microbial Community - Li Liu; Xiang Li; Tianyu Li; Yuan Xie; Zhuoyang Cao; Ping Fang (Journal of Soil Science and Plant Nutrition, 2022)

The acute effect and lag effect analysis between exposures to ambient air pollutants and spontaneous abortion: a case-crossover study in China, 2017–2019 - Wenzheng Zhou; Xin Ming; Qing Chen; Xiaoli Liu; Ping Yin (Environmental Science and Pollution Research, 2022)
Introduction Recent studies demonstrated that living in areas with high ambient air pollution may have adverse effects on pregnancy outcomes, but few studies have investigated its association with spontaneous abortion. Further investigation is needed to explore the acute effect and lag effect of air pollutants exposure on spontaneous abortion. Objective To investigate the acute effect and lag effect between exposure to ambient air pollutants and spontaneous abortion. Methods Research data of spontaneous abortion were collected from the Chongqing Health Center for Women and Children (CQHCWC) in China. The daily ambient air pollution exposure measurements were estimated for each woman using inverse distance weighting from monitoring stations. A time-stratified, case-crossover design combined with distributed lag linear models was applied to assess the associations between spontaneous pregnancy loss and exposure to each of the air pollutants over lags 0–7 days, adjusted for temperature and relative humidity. Results A total of 1399 women who experienced spontaneous pregnancy loss events from November 1, 2016, to September 30, 2019, were selected for this study. Maternal exposure to particulate matter 2.5 (PM 2.5 ), particle matter 10 (PM 10 ) nitrogen dioxide (NO 2 ), and sulfur dioxide (SO 2 ) exhibited a significant association with spontaneous abortion. For every 20 μg/m 3 increase in PM 2.5 , PM 10 , NO 2 , and SO 2 , the RRs were 1.18 (95% CI : 1.06, 1.34), 1.12 (95% CI , 1.04–1.20), 1.15 (95% CI : 1.02, 1.30), and 1.92 (95% CI : 1.18, 3.11) on lag day 3, lag day 3, lag day 0, and lag day 3, respectively. In two-pollutant model combined with PM 2.5 and PM 10 , a statistically significant increase in spontaneous abortion incidence of 18.0% ( RR = 1.18, 95% CI : 1.06, 1.32) was found for a 20 μg/m 3 increase in PM 2.5 exposure, and 11.2% ( RR = 1.11, 95% CI : 1.03, 1.20) for a 20 μg/m 3 increase in PM 10 exposure on lag day 3, similar to single-pollutant model analysis. Conclusion Maternal exposure to high levels of PM 2.5 , PM 10 , NO 2 , and SO 2 during pregnancy may increase the risk of spontaneous abortion for acute effects and lag effects. Further research to explore sensitive exposure time windows is needed.

Particle size effects in microbial characteristics in thermophilic anaerobic digestion of cattle manure containing copper oxide - Yuanyuan Lu; Xuna Liu; Yanjun Miao; Efthalia Chatzisymeon; Lina Pang; Luqing Qi; Ping Yang; Hongyan Lu (Environmental Science and Pollution Research, 2022)

Influence of microplastics on triclosan bioaccumulation and metabolomics variation in Tilapia fish tissues - Yu-Wei Jia; Ping Wang; Sheng Yang; Zheng Huang; Yue-Hong Liu; Jian-Liang Zhao (Environmental Science and Pollution Research, 2022)

Evaluation of the microwave-assisted organic acid separation of organic sulfur from high-sulfur coal - Jin Liu; Chaoshun Jiang; Hao Shen; Zheng Pang; Zhi Wang; Ping Li; Xing Xing (Clean Technologies and Environmental Policy, 2022)

Development and Validation of a Diagnostic Nomogram to Predict the Anthracycline-Induced Early Cardiotoxicity in Children with Hematological Tumors - Zhi-yuan Liu; Yun-gong Wang; Xiao-bi Huang; Xiao-hui Qi; Cui-ping Qian; Sheng Zhao (Cardiovascular Toxicology, 2022)
This study aimed to establish and validate an effective nomogram to predict the risk of cardiotoxicity in children after each anthracycline treatment. According to the inclusion and exclusion criteria, the eligible children were randomly divided into the training cohort (75%) and the validation cohort (25%). Least absolute shrinkage and selection operator (LASSO) regression was used to select the predictors and a nomogram was developed. Then, concordance index ( C -index), the area under the curve (AUC), Hosmer–Lemeshow (H–L) test, and decision curve analysis (DCA) were employed to evaluate the performance and clinical utility of nomogram. Internal validation was processed to inspect the stability of the model. A total of 796 eligible children were included in this study and divided into a training set ( n = 597) and a validation set ( n = 199). LASSO regression analysis revealed that cumulative anthracycline dose, ejection fractions, NT-proBNP, and diastolic dysfunction were effective predictors of cardiotoxicity. The nomogram was established based on these variables. The C -index and the AUC of the predicting nomogram were 0.818 in the training cohort and 0.773 in the validation cohort, suggesting that the nomogram had good discrimination. The calibration curve of the nomogram presented no significant deviation from the reference line, and the P -value of the H–L test was 0.283, implying a preferable degree of calibration. The threshold of DCA also reflects that the nomogram is clinically useful. A nomogram was developed to predict anthracycline chemotherapy-induced cardiotoxicity in children with hematological tumors. The nomogram has a good prediction effect and can provide a reference for clinicians’ diagnosis and treatment.

Arias intensity attenuation relationship in Sichuan–Yunnan region, China - Ping Liu; Tongjie Ren (Bulletin of Earthquake Engineering, 2022)

Effects of near-fault pulse-type ground motions on high-speed railway simply supported bridge and pulse parameter analysis - Tuo Zhou; Lizhong Jiang; Ping Xiang; Zhipeng Lai; Yuntai Zhang; Xiang Liu (Bulletin of Earthquake Engineering, 2022)

FOSL2 deficiency delays nonalcoholic steatohepatitis progression by regulating LY6D-mediated NLRP3 activation - Pei-Xin Hu; Mei-Yan Sheng; Yan-Ping Liu; Chun-Qing Zhang (Human Cell, 2022)

Two new terpenes from the aerial parts of Clematis chinensis Osbeck - Sun Ye; Liu Yan; Yan-Ping Sun; Xiao-Mao Li; Wang Si-Yi; Juan Pan; Wei Guan; Yuan Liu; Anam Naseem; Bing-You Yang; Hai-Xue Kuang (Natural Product Research, 2022)

Recent advances in metabolic regulation and bioengineering of gibberellic acid biosynthesis in Fusarium fujikuroi - Hao-Nan Wang; Xia Ke; Jun-Ping Zhou; Zhi-Qiang Liu; Yu-Guo Zheng (World Journal of Microbiology and Biotechnology, 2022)

Persistence of Two Common Chemical Oxidants for Soil and Groundwater Remediation: Impacts of Water Chemistry and Subsurface Minerals - Jie Ma; Jing Wen; Xin Yang; Yanbo Liu; Guangyao Zhai; Shuyu Liu; Hanyu Liu; Gangsen Yue; Huaxia Dong; Ping Zhang (Water, Air, & Soil Pollution, 2022)

Potassium Permanganate–Based Controlled Release Beads to Remediate Groundwater Pollution: Alkylbenzene Degradation and Permanganate Release Kinetics - Jie Ma; Yao Ma; Yanbo Liu; Guangyao Zhai; Shuyu Liu; Hanyu Liu; Gangsen Yue; Xingying Lan; Yuan Feng; Xiaoyuan Qiu; Ping Zhang (Water, Air, & Soil Pollution, 2022)

Mechanisms Underlying the Slip and Failure of Coal-Rock Parting-Coal Structures Under Unloading Conditions - Yang Liu; Cai-Ping Lu; Zi-Yi Xiao; Ying Guo (Rock Mechanics and Rock Engineering, 2022)

Updated taxonomy of Chinese Clavaria subg. Syncoryne (Clavariaceae, Agaricales): description of two new species and one newly recorded species - Jun Yan; Gui-Wu Li; Wen-Hao Liu; Zuo-Hong Chen; Ping Zhang (Mycological Progress, 2022)

Recombinant jurkat cells (HMGN2-T cells) secrete cytokines and inhibit the growth of tumor cells - Huanhuan Li; Xueqiang Wu; Dingfang Bu; Lihua Wang; Xueju Xu; Yingchao Wang; Yufeng Liu; Ping Zhu (Journal of Molecular Histology, 2022)

Feed types affect the growth, nutrient utilization, digestive capabilities, and endocrine functions of Megalobrama amblycephala: a comparative study between pelleted and extruded feed - Chao-Fan He; Xiang-Fei Li; Guang-Zhen Jiang; Ling Zhang; Miao Sun; Ya-Ping Ge; Wei-Liang Chen; Wen-Bin Liu (Fish Physiology and Biochemistry, 2022)

Hydrogen sulfide supplement preserves mitochondrial function of retinal ganglion cell in a rat glaucoma model - Shouyue Huang; Ping Huang; Huan Yu; Junjue Chen; Xiaohong Liu; Jing Wang; Xi Shen; Yisheng Zhong (Cell and Tissue Research, 2022)

Fertility conversion between cytoplasmic maintainer lines and restorer lines through molecular marker-assisted selection in pepper (Capsicum annuum L.) - Fu-Sen Ren; Hai-Feng Yang; Yu-Shun Jiao; Rui-Ping Zhang; Zhi-Wei Guo; He-Juan Liu; Qiang Sun; Xi-Jun Li; Xiu-Fang Tan; Bei Zhang; Jun-Qi Zhen; Yan-Qi Dong (Biologia, 2022)

Sphingopyxis yananensis sp. nov., a novel 2-nitropropane degrading bacterium isolated from a microbial fermentation bed substrate - Chao-chao Zheng; Ying-ying Jiang; Tian-fei Yu; Jing Li; Jia-min Ai; Mai-ping Li; Xiao-dong Liu; Zhen-shan Deng (Archives of Microbiology, 2022)

The effects of dietary fermented wheat bran polysaccharides on mucosal and serum immune parameters, hepatopancreas antioxidant indicators, and immune-related gene expression of common carp (Cyprinus carpio) juveniles - Rui-Fang Wang; Yuan Wang; Jun Zhang; Mei-Qi Weng; Yu-Hui Liu; Qiu-Yan Cheng; Min Song; Yan-Ping Yang; Xiao-Ping An; Jing-Wei Qi (Aquaculture International, 2022)

Dynamic common correlated effects of pandemic uncertainty on environmental quality: fresh insights from East-Asia and Pacific countries - Zhen Liu; Ping Pang; Wei Fang; Sajid Ali; Muhammad Khalid Anser (Air Quality, Atmosphere & Health, 2022)

Deepened snow loosens temporal coupling between plant and microbial N utilization and induces ecosystem N losses - Zhou Jia; Ping Li; Yuntao Wu; Pengfei Chang; Meifeng Deng; Luyin Liang; Sen Yang; Chengzhang Wang; Bin Wang; Lu Yang; Xin Wang; Zhenhua Wang; et al. (Global Change Biology, 2022)
Seasonal differences in plant and microbial nitrogen (N) acquisition are believed to be a major mechanism that maximizes ecosystem N retention. There is also a concern that climate change may interrupt the delicate balance in N allocation between plants and microbes. Yet, convincing experimental evidence is still lacking. Using a 15 N tracer, we assessed how deepened snow affects the temporal coupling between plant and microbial N utilization in a temperate Mongolian grassland. We found that microbial 15 N recovery peaked in winter, accounting for 22% of the total ecosystem 15 N recovery, and then rapidly declined during the spring thaw. By stimulating N loss via N 2 O emission and leaching, deepened snow reduced the total ecosystem 15 N recovery by 42% during the spring thaw. As the growing season progresses, the 15 N released from microbial biomass was taken up by plants, and the competitive advantage for N shifted from microbes to plants. Plant 15 N recovery reached its peak in August, accounting for 17% of the total ecosystem 15 N recovery. The Granger causality test showed that the temporal dynamics of plant 15 N recovery can be predicted by microbial 15 N recovery under ambient snow but not under deepened snow. In addition, plant 15 N recovery in August was positively correlated with and best explained by microbial 15 N recovery in March. The lower microbial 15 N recovery under deepened snow in March reduced plant 15 N recovery by 73% in August. Together, our results provide direct evidence of seasonal differences in plant and microbial N utilization that are conducive to ecosystem N retention; however, deepened snow disrupted the temporal coupling between plant–microbial N use and turnover. These findings suggest that changes in snowfall patterns may significantly alter ecosystem N cycling and N‐based greenhouse gas emissions under future climate change. We highlight the importance of better representing winter processes and their response to winter climate change in biogeochemical models when assessing N cycling under global change.

Microplastic prevalence in marine fish from onshore Beibu Gulf, South China Sea - Jayamini Bimali Koongolla; Lang Lin; Chang-Ping Yang; Yun-Feng Pan; Heng-Xiang Li; Shan Liu; Xiang-Rong Xu (Frontiers in Marine Science, 2022)
In recent years, microplastics have been widely detected in marine fish and may pose potential risks to fish and human health. Even though microplastic pollution is a critical issue, it represents as yet non-quantified threat for some context in the marine environment. In this study, 271 individuals comprising 32 species of marine fish collected from Beibu Gulf were examined for microplastic prevalence, with an aim to provide data on the abundance, physical classification, and chemical characterization of microplastics in the great bay along South China Sea. The results showed that the occurrence rate of microplastics was 93.7%, and the average abundance of microplastics was 1.02 ± 0.18 items per individual (ranging from 0.03 to 4.00 items per individual). Microplastic accumulation was observed with a great variation in different species, body sizes, living habitats, and feeding habits of marine fishes. The dominant polymers identified by μ-FTIR were polyethylene terephthalate and polypropylene. Fibers, smaller sizes (<1 mm), and transparent color were the major characteristics of the detected microplastics, which might be important factors affecting the bioaccumulation. The present study revealed that microplastics in marine fish is a widespread issue in onshore Beibu Gulf.

Four new polyacetylenes from the roots of Saposhnikovia divaricata - Yan Sun; Yan-Ping Sun; Yan Liu; Juan Pan; Wei Guan; Xiao-Mao Li; Yuan Liu; Anam Naseem; Bing-You Yang; Hai-Xue Kuang (Natural Product Research, 2022)

Prenatal and postnatal transfer of perfluoroalkyl substances from mothers to their offspring - Yingxue Liu; An Li; Qi An; Kai Liu; Ping Zheng; Shanshan Yin; Weiping Liu (Critical Reviews in Environmental Science and Technology, 2022)

Correction to: Exercise Rehabilitation and/or Astragaloside Attenuate Amyloid-beta Pathology by Reversing BDNF/TrkB Signaling Deficits and Mitochondrial Dysfunction - Yu-Lin Wang; Chung-Ching Chio; Shu-Chun Kuo; Chao-Hung Yeh; Jui-Ti Ma; Wen-Pin Liu; Mao-Tsun Lin; Kao-Chang Lin; Ching-Ping Chang (Molecular Neurobiology, 2022)

Rhodoflexus caldus gen. nov., sp. nov., a new member of the phylum Bacteroidota isolated from a hot spring sediment - Ze-Tao Liu; Lan Liu; Wen-Dong Xian; Zheng-Han Lian; Jun-Yi Dai; Bao-Zhu Fang; Meng-Meng Li; Ai-Ping Lv; Zhen-Hao Luo; Jian-Yu Jiao; Wen-Jun Li (Antonie van Leeuwenhoek, 2022)

Cadinane-type sesquiterpenes with potential anti-inflammatory and anti-HIV activities from the stems and leaves of Mappianthus iodoides - Yan-Ping Liu; Xiao-Mei Yu; Ze-Hua Qiao; Bo Jiang; Lan Xie; Hao-Xuan Tang; Xiao Liang; Yan-Hui Fu (Natural Product Research, 2022)

Full-Length Transcriptome Construction of the Blue Crab Callinectes sapidus - Baoquan Gao; Jianjian Lv; Xianliang Meng; Jitao Li; Yukun Li; Ping Liu; Jian Li (Frontiers in Marine Science, 2022)

Antioxidant, Transcriptomic and Metabonomic Analysis of Hepatopancreatic Stress Resistance in Exopalaemon carinicauda Following Astaxanthin Feeding - Wenyang Li; Jiajia Wang; Jitao Li; Ping Liu; Jian Li; Fazhen Zhao (Frontiers in Marine Science, 2022)
Astaxanthin (Axn) is a xanthophyll carotenoid that has previously been shown to suppress hepatic inflammation, reduce oxidative liver damage, and improve metabolic profiles. Exopalaemon carinicauda ( E. carinicauda ) is an economically important fishery species in China that has been found to exhibit increased body weight following Axn feeding as compared to a standard diet. In this study, dietary Axn can significantly decreased MDA content, T-AOC and significantly increased SOD, GSH and CAT activities in shrimp hepatopancreas. Moreover, transcriptome and metabolome of E. carinicauda after Axn feeding were investigated to identify the mechanism of the effect of Axn on E. carinicauda . The transcriptomic data revealed that a total 99 different expression genes (DEGs) were identified between the Axn and control groups, of which 47 and 52 were upregulated and downregulated, respectively. DEGs of E. carinicauda such as catherpsin, actin and PARP after Axn feeding were associated with apoptosis and immune system. The metabolomic analysis revealed that A total of 73 different expression metabolites (DEMs) were identified in both metabolites, including 30 downregulated metabolites and 43 upregulated metabolites. And Axn participate in metabolism processes in hepatopancreas of E. carinicauda , including the TCA cycle, amino acid metabolism and lipid metabolism. The multiple comparative analysis implicated that Axn can improve the antioxidant capacity of hepatopancreas and the energy supply of hepatopancreas mitochondria, and then improve the ability of anti-apoptosis. Collectively, all these results will greatly provide new insights into the molecular mechanisms underlying tolerance of adverse environment in E. carinicauda .

Hasubanan alkaloids with anti-inflammatory activity from Stephania longa - Hui Liu; Wan-Qin Liao; Rong-Xiao Lin; Lixia Fan; Jinyan Sun; Hong-Yuan Chen; Fang Liu; An-Ping Yang (Natural Product Research, 2022)

Discovery of potential anti-SARS-CoV-2 drugs based on large-scale screening in vitro and effect evaluation in vivo - Haoran Peng; Cuiling Ding; Liangliang Jiang; Wanda Tang; Yan Liu; Lanjuan Zhao; Zhigang Yi; Hao Ren; Chong Li; Yanhua He; Xu Zheng; Hailin Tang; et al. (Science China Life Sciences, 2022)

High-Density Lipoprotein Is Associated with Leukoaraiosis Severity in Patients with Acute Ischemic Stroke - Ping Wang; Zhaoxia Liu; Xuan Liu; Jing Sun; Zhiyuan Qian; Xingshun Xu (Neurotoxicity Research, 2022)

Bedside Diagnosis for Disseminated Deep Dermatophytosis: a Case Series Study - Xiu-Jiao Xia; Hong Shen; Hui-Lin Zhi; Yan Zhong; Bo Sang; Wen-Wen Lv; Qiu-Ping Li; Ze-Hu Liu (Mycopathologia, 2022)

Research on Ecological Security of Shengjin Lake Wetland (Anhui Province of China) Based on TM Images - Zhili Xu; Bin Dong; Xiang Gao; Ping Wang; Qing Wang; Sheng Li; Haifeng Xu; Yaru Liu; Tong Wang; Chunqiu Ren (Journal of the Indian Society of Remote Sensing, 2022)

Breast Cancer Awareness Based on Health Information Literacy and Influential Factors among Female Nursing Students in China - Shu Yang; Ping Li; Lin Yu; Na Liu; Jie Wang; Pingping Guo; Xuehui Zhang; Wei Zhang (Journal of Cancer Education, 2022)

tensorGSEA: Detecting Differential Pathways in Type 2 Diabetes via Tensor-Based Data Reconstruction - Xu Qiao; Xianru Zhang; Wei Chen; Xin Xu; Yen-Wei Chen; Zhi-Ping Liu (Interdisciplinary Sciences: Computational Life Sciences, 2022)

H19 is involved in the regulation of inflammatory responses in acute gouty arthritis by targeting miR-22-3p - Yan-Yan Xue; Hui-Jie Liu; Zhan-Juan Sun; Ting Xiang; Ping Shao (Immunologic Research, 2022)

C2CD4A/B variants in the predisposition of lung cancer in the Chinese Han population - Feifei Han; Lu Qian; Yi Zhang; Ping Liu; Rui Li; Mingwei Chen (Functional & Integrative Genomics, 2022)

Study on the Characteristics and Utilization of the Danxia Geoheritage in Northwest China: Implication on Popularly Scientific Education and Undergraduate Teaching - Heping Shu; Fanyu Zhang; Ping Liu (Geoheritage, 2022)

Analysis of degradation and pathways of three common antihistamine drugs by NaClO, UV, and UV-NaClO methods - Anchen Liu; Wenting Lin; Senwen Ping; Wenqi Guan; Ningyi Hu; Sichun Zheng; Yuan Ren (Environmental Science and Pollution Research, 2022)

Rapid triage for ischemic stroke: a machine learning-driven approach in the context of predictive, preventive and personalised medicine - Yulu Zheng; Zheng Guo; Yanbo Zhang; Jianjing Shang; Leilei Yu; Ping Fu; Yizhi Liu; Xingang Li; Hao Wang; Ling Ren; Wei Zhang; Haifeng Hou; et al. (EPMA Journal, 2022)
Background Recognising the early signs of ischemic stroke (IS) in emergency settings has been challenging. Machine learning (ML), a robust tool for predictive, preventive and personalised medicine (PPPM/3PM), presents a possible solution for this issue and produces accurate predictions for real-time data processing. Methods This investigation evaluated 4999 IS patients among a total of 10,476 adults included in the initial dataset, and 1076 IS subjects among 3935 participants in the external validation dataset. Six ML-based models for the prediction of IS were trained on the initial dataset of 10,476 participants (split participants into a training set [80%] and an internal validation set [20%]). Selected clinical laboratory features routinely assessed at admission were used to inform the models. Model performance was mainly evaluated by the area under the receiver operating characteristic (AUC) curve. Additional techniques—permutation feature importance (PFI), local interpretable model-agnostic explanations (LIME), and SHapley Additive exPlanations (SHAP)—were applied for explaining the black-box ML models. Results Fifteen routine haematological and biochemical features were selected to establish ML-based models for the prediction of IS. The XGBoost-based model achieved the highest predictive performance, reaching AUCs of 0.91 (0.90–0.92) and 0.92 (0.91–0.93) in the internal and external datasets respectively. PFI globally revealed that demographic feature age, routine haematological parameters, haemoglobin and neutrophil count, and biochemical analytes total protein and high-density lipoprotein cholesterol were more influential on the model’s prediction. LIME and SHAP showed similar local feature attribution explanations. Conclusion In the context of PPPM/3PM, we used the selected predictors obtained from the results of common blood tests to develop and validate ML-based models for the diagnosis of IS. The XGBoost-based model offers the most accurate prediction. By incorporating the individualised patient profile, this prediction tool is simple and quick to administer. This is promising to support subjective decision making in resource-limited settings or primary care, thereby shortening the time window for the treatment, and improving outcomes after IS.

A critical review on EDTA washing in soil remediation for potentially toxic elements (PTEs) pollutants - Yaoning Chen; Hongjuan Jiang; Yuanping Li; Yihuan Liu; Yanrong Chen; Li Chen; Xinli Luo; Ping Tang; Haoqin Yan; Mengyang Zhao; Yu Yuan; Suzhen Hou (Reviews in Environmental Science and Bio/Technology, 2022)

Abundance, Diversity and Functional Potentials of Planktonic Bacteria and Microeukaryotes in the Coral-Reef System of Xisha Islands, China - Xiaoli Zhang; Lei Wang; Saijun Peng; Qiyue Wuzhong; Lei Zhang; Zhijun Dong; Tingting Sun; Ping Liu; Qianqian Zhang; Jianmin Zhao (Journal of Ocean University of China, 2022)

Components Analysis of Recycled Alkali Black Liquor Combined with Corn Straw Under Ozone Pretreatment - Xiaohong Lu; Fei Li; Yiming Li; Shuo Fang; Xia Zhou; Zhezhen Zhao; Ping Liu (BioEnergy Research, 2022)

Evaluation of genetic variants in nucleosome remodeling and deacetylase (NuRD) complex subunits encoding genes and gastric cancer susceptibility - Yujuan Zhang; Guoquan Tao; Ping Liu; Kai Lu; Zhichao Han; Hanting Liu; Mulong Du; Meilin Wang; Haiyan Chu; Zhengdong Zhang (Archives of Toxicology, 2022)

Qipengyuania thermophila sp. nov., isolated from a Chinese hot spring - Zi-Yu Zhao; Ting-Ting Xia; Jian-Yu Jiao; Lan Liu; Qing-Yang Su; Meng-Meng Li; Ai-Ping Lv; Yu-Ting Ouyang; Wen-Jun Li; Hong Ming (Archives of Microbiology, 2022)

Expanding the clinical spectrum of adult-onset neuronal intranuclear inclusion disease - Yuwen Cao; Jingying Wu; Yunhua Yue; Chao Zhang; Shihua Liu; Ping Zhong; Shige Wang; Xiaojun Huang; Weiping Deng; Jing Pan; Lan Zheng; Qing Liu; et al. (Acta Neurologica Belgica, 2022)

SLOSS ‐based inferences in a fragmented landscape depend on fragment area and species–area slope - Jinliang Liu; Zachary G. MacDonald; Xingfeng Si; Lingbing Wu; Di Zeng; Guang Hu; Ping Ding; Mingjian Yu (Journal of Biogeography, 2022)
Aims Whether a Single Large Or Several Small (SLOSS) habitat patches contain more species is central to the debate about how habitat fragmentation threatens species diversity. However, the geographical and biogeographical variables that affect emergent SLOSS patterns remain poorly understood. Here, we quantified SLOSS‐based diversity patterns of woody plant, bird and spider assemblages in a subtropical archipelago of land bridge islands. Location Thousand Island Lake, Zhejiang Province, China. Taxon Woody plants, birds and spiders. Methods We analysed species accumulation curves and species–area relationships (SARs) to quantify SLOSS‐based patterns of all, common and rare species for each taxon across different groupings of islands. Differences in the number of species between a single large island and sets of several small islands were measured in these analyses using a Saturation index (SI) and SLOSS index. Generalized additive models were used to assess the relationships between SI and SLOSS index values and the maximum area of islands included in the analysis, the slope of SARs (i.e. z ‐score) and the degree of nestedness. Results SI values increased with the maximum area of islands for three taxa, while SLOSS index values only increased with the maximum island area for woody plants. SI values increased as z ‐scores of woody plants decreased, and showed a quadratic relationship for birds and spiders. SLOSS index values decreased as z ‐scores of three taxa increased. The degree of nestedness and SI values or SLOSS index values were weakly correlated with all, rare and common species in the three taxa. Main conclusions SLOSS‐based inferences of fragmentation effects are contingent on variation in the maximum area of patches included in analyses and the slope of SARs in fragmentated landscapes. Whether conservation efforts should prioritize a single large or several small patches depends on the geographical (e.g. maximum fragment area) and biogeographical (e.g. slope of SAR) attributes of a fragmentated landscape.

Episodic Neoproterozoic extension-related magmatism in the Altyn Tagh, NW China: implications for extension and breakup processes of Rodinia supercontinent - Jiang-bo Hao; Chao Wang; Ji-heng Zhang; Liang Liu; Yong-sheng Gai; Hang Li; Zun-pu Yu; Joseph G Meert; Xiao-ping Long; Xiao-kui Sun; Shuai Zhang (International Geology Review, 2022)

Community Structure of Benthic Macrofauna and the Ecological Quality of Mangrove Wetlands in Hainan, China - Ping Li; Jingli Liu; Jiankun Bai; Yifan Tong; Yuchen Meng; Xiaoping Diao; Ke Pan; Xiaoshan Zhu; Guanghui Lin (Frontiers in Marine Science, 2022)
Few studies have systematically assessed the ecological status of mangrove wetlands following the stress of anthropogenic activities in China. This study investigated the spatial and seasonal distribution of benthic macroinvertebrate communities and assessed the ecological quality of mangrove habitats on an island scale in Hainan, China (containing the third largest mangrove area of China and the highest mangrove species richness). For the benthic macrofauna community structure, a total of 102 macrobenthic taxa belonging to 50 families were identified, with Crustaceans, Molluscs, Polychaetes, and Oligochaeta having relative abundances of 52.3%, 36.1%, 10.8%, and 0.8%, respectively. Decapoda and Gastropoda dominated the benthic community abundance. Non-metric multidimensional scaling and an analysis of similarities revealed significantly different macroinvertebrate assemblages among the regions during the two seasons. The South mangroves had the lowest macrofauna species numbers, biodiversity, richness, and abundance. The macrofaunal species richness, Shannon index, Margalef index, abundance, and biomass markedly affected by region and season. As indicated by the biotic indices AMBI (AZTI’s Marine Biotic Index) and M-AMBI, more than half of the mangrove habitats on Hainan Island were slightly to heavily disturbed and had poor to moderate ecological quality. Our results recommend long-term monitoring for evaluating the quality status of mangrove wetlands and avoiding extensive land-use conversion of mangroves. Holistic approaches considering ecological characteristics and combining information on both floral and faunal functionality would contribute to the effective management and conservation of mangroves in disturbed areas.

Monascuslactams A–D, cytotoxic γ-lactams from marine fungus Monascus albidus BB3 - Qi Guo; Xiao-Ming Dai; Wen-Jian Lan; Liu-Ping Chen; Chi-Keung Lam; Gong-Kan Feng; Rong Deng; Xiao-Feng Zhu; Hou-Jin Li (Natural Product Research, 2022)

Prenylated coumarins from the fruits of Artocarpus heterophyllus with their potential anti-inflammatory and anti-HIV activities - Lei Tao; Ya-Ting Zhuo; Ze-Hua Qiao; Juan Li; Hao-Xuan Tang; Qiao-Mei Yu; Yun-Yao Liu; Yan-Ping Liu (Natural Product Research, 2022)

Citrus flavonoids and their antioxidant evaluation - Yue Wang; Xiao-Juan Liu; Jie-Biao Chen; Jin-Ping Cao; Xian Li; Chong-De Sun (Critical Reviews in Food Science and Nutrition, 2022)

One new piperazinedione isolated from a mangrove-derived fungus Aspergillus niger JX-5 - Meng Bai; Yue Wang; Ting Liu; Yu-Xing Lian; Qi-Qi Bai; Xiao-Ping Song; Chang-Ri Han; Cai-Juan Zheng; Guang-Ying Chen (Natural Product Research, 2022)

Expert consensus on organizing the multidisciplinary team (MDT) diagnosis and treatment of hepato-pancreato-biliary diseases in China - Binhao Zhang; Jian Zhou; Weifen Xie; Kaishan Tao; Shichun Lu; Xianglin Yuan; Lianxin Liu; Weilin Wang; Yilei Mao; Ping Bie; Jingfeng Liu; Xinyu Bi; et al. (Science China Life Sciences, 2022)

The study of schizogenous formation of secretory ducts in Ferula ferulaeoides (Steud.) Korov. - Meng-meng Liu; Yuan-yuan Zhao; Ying Ma; Shuang-shuang Liu; Jia-qi Yao; Ya-ping Chi; Hui-fang Li; Kai Liao; Yun Zhu (Protoplasma, 2022)

Effects of Involuntary and Voluntary Exercise in Combination with Acousto-Optic Stimulation on Adult Neurogenesis in an Alzheimer's Mouse Model - Wan-yi Li; Jun-yan Gao; Su-Yang Lin; Shao-tao Pan; Biao Xiao; Yu-tao Ma; Kai Xie; Wei Shen; Zhi-tao Liu; Guang-yu Li; Jie-jie Guo; Qin-wen Wang; et al. (Molecular Neurobiology, 2022)

Exercise Rehabilitation and/or Astragaloside Attenuate Amyloid-beta Pathology by Reversing BDNF/TrkB Signaling Deficits and Mitochondrial Dysfunction - Yu-Lin Wang; Chung-Ching Chio; Shu-Chun Kuo; Chao-Hung Yeh; Jui-Ti Ma; Wen-Pin Liu; Mao-Tsun Lin; Kao-Chang Lin; Ching-Ping Chang (Molecular Neurobiology, 2022)

TREM2 and CD163 Ameliorate Microglia-Mediated Inflammatory Environment in the Aging Brain - Xue Han; Yu-Jia Liu; Bin-Wen Liu; Zheng-Liang Ma; Tian-Jiao Xia; Xiao-Ping Gu (Journal of Molecular Neuroscience, 2022)

Residential proximity to major roadway and progression in physical disability in older adults in China - Jing Hu; Wenqian Chen; Lei Li; Yu Zhang; Hongwei Jiang; Wenhua Liu; Ping Yin (Environmental Science and Pollution Research, 2022)

Urinary phthalate metabolites in pregnant women: occurrences, related factors, and association with maternal hormones - Wei Wu; Zhi-li Ma; Fang Yang; Ping Wu; De-xin Zhang; Rong Zeng; Dan-ling Sun; Liu Cao (Environmental Science and Pollution Research, 2022)

Diel variation in anti-predation behavior of a ground squirrel and relationships between vigilance and escape - Ling-Ying Shuai; Mei-Ting Liu; A.-Ping Zhu; Yuan-Yuan Cao; Fu-Shun Zhang (Behavioral Ecology and Sociobiology, 2022)

Geochronological, geochemical, and P–T path constraints on the late Paleoproterozoic continent–continent collision orogeny in the Quruqtagh Block, Tarim Craton - Tao Cui; Shan-Shan Li; Rui-Qing Guo; Germain Bishikwabo; Xiang-Kuan Gong; Gui-Ping Liu; Yu Guo (Arabian Journal of Geosciences, 2022)

Genome-based reclassification of the genus Meiothermus along with the proposal of a new genus Allomeiothermus gen. nov - Jian-Yu Jiao; Zheng-Han Lian; Ze-Tao Liu; Lan Liu; Meng-Meng Li; Ai-Ping Lv; Wen-Dong Xian; Ting Zhou; Zhitang Lyu; Nimaichand Salam; Wen-Jun Li (Antonie van Leeuwenhoek, 2022)

Chemical constituents of Viscum coloratum (Kom.) Nakai and their cytotoxic activities - Ying-Ying Chen; Jiang-Ping Hou; Ling Huang; Afsar Khan; Fei-Fei Xing; Xiao-Han Zhang; De-Feng Han; Shi-Li Yan; Gui-Dong Cao; Qi-Yang Jiao; Dejie Liu; Xuwei Zhu; et al. (Natural Product Research, 2022)

Two new dammarane-type triterpenoids from the green walnut husks of Juglans mandshurica Maxim - Yuan-Yuan Zhou; Hui-Rui Gao; Hong-Juan Song; Dan-Da Ma; Xiao-Juan Zhang; Yan-Ping Sun; Yan Liu; Xiao-Li Wang; Bing-You Yang; Hai-Xue Kuang (Natural Product Research, 2022)

Chemical constituent from the roots of Solanum melongena L. and their potential anti-inflammatory activity - Yan Liu; Xin Yin; Yan-ping Sun; Yuan Liu; Yuan-Yuan Zhou; Juan Pan; Wei Guan; Bing-You Yang; Hai-Xue Kuang (Natural Product Research, 2022)

Five new phloroglucinol derivatives from Syzygium brachyantherum and their α -glucosidase and PTP1B inhibitory activities - Wen Xu; Shao-Hua Xu; Li Wang; Zhen Zang; Yan Zhao; Jing-Ping Liu; Jing Yang; Yong Zhao (Natural Product Research, 2022)

Consolidation behavior and microstructure properties of cement-treated dredged soil during the stress curing - Xingxing He; Yijun Chen; Yuan Li; Dongdong Guo; Qiang Xue; Shiquan Wang; Ping Wang; Yong Wan; Lei Liu (Marine Georesources & Geotechnology, 2022)

Dissection of the practical soybean breeding pipeline by developing ZDX1, a high-throughput functional array - Rujian Sun; Bincheng Sun; Yu Tian; Shanshan Su; Yong Zhang; Wanhai Zhang; Jingshun Wang; Ping Yu; Bingfu Guo; Huihui Li; Yanfei Li; Huawei Gao; et al. (Theoretical and Applied Genetics, 2022)
Key message We developed the ZDX1 high-throughput functional soybean array for high accuracy evaluation and selection of both parents and progeny, which can greatly accelerate soybean breeding. Abstract Microarray technology facilitates rapid, accurate, and economical genotyping. Here, using resequencing data from 2214 representative soybean accessions, we developed the high-throughput functional array ZDX1, containing 158,959 SNPs, covering 90.92% of soybean genes and sites related to important traits. By application of the array, a total of 817 accessions were genotyped, including three subpopulations of candidate parental lines, parental lines and their progeny from practical breeding. The fixed SNPs were identified in progeny, indicating artificial selection during the breeding process. By identifying functional sites of target traits, novel soybean cyst nematode-resistant progeny and maturity-related novel sources were identified by allele combinations, demonstrating that functional sites provide an efficient method for the rapid screening of desirable traits or gene sources. Notably, we found that the breeding index (BI) was a good indicator for progeny selection. Superior progeny were derived from the combination of distantly related parents, with at least one parent having a higher BI. Furthermore, new combinations based on good performance were proposed for further breeding after excluding redundant and closely related parents. Genomic best linear unbiased prediction (GBLUP) analysis was the best analysis method and achieved the highest accuracy in predicting four traits when comparing SNPs in genic regions rather than whole genomic or intergenic SNPs. The prediction accuracy was improved by 32.1% by using progeny to expand the training population. Collectively, a versatile assay demonstrated that the functional ZDX1 array provided efficient information for the design and optimization of a breeding pipeline for accelerated soybean breeding.

Fine mapping of powdery mildew resistance gene MlWE74 derived from wild emmer wheat (Triticum turgidum ssp. dicoccoides) in an NBS-LRR gene cluster - Keyu Zhu; Miaomiao Li; Haibin Wu; Deyun Zhang; Lingli Dong; Qiuhong Wu; Yongxing Chen; Jingzhong Xie; Ping Lu; Guanghao Guo; Huaizhi Zhang; Panpan Zhang; et al. (Theoretical and Applied Genetics, 2022)

OsFLA1 encodes a fasciclin-like arabinogalactan protein and affects pollen exine development in rice - Yao Deng; Yingchun Wan; Weichi Liu; Lisha Zhang; Kai Zhou; Ping Feng; Guanghua He; Nan Wang (Theoretical and Applied Genetics, 2022)

Association of temperature variability with the risk of initial outpatient visits for allergic rhinitis: a time-series study in Changchun - Man Xu; Pan Ke; Ruoling Chen; Ping Hu; Bing Liu; Jian Hou; Li Ke (Environmental Science and Pollution Research, 2022)

Association between congenital heart defects and maternal manganese and iron concentrations: a case–control study in China - Meixian Wang; Yan Tian; Ping Yu; Nana Li; Ying Deng; Lu Li; Hong Kang; Dapeng Chen; Hui Wang; Zhen Liu; Juan Liang (Environmental Science and Pollution Research, 2022)
To investigate the correlation between maternal manganese and iron concentrations and the risk of CHD among their infant. A multi-center hospital-based case control study was conducted in China. There were 322 cases and 333 controls have been selected from pregnant women who received prenatal examinations. Correlations between CHDs and maternal manganese and iron concentrations were estimated by conditional logistic regression. Moreover, the interaction between manganese and iron on CHDs was analyzed. Compared with the controls, mothers whose hair manganese concentration was 3.01 μg/g or more were more likely to have a child with CHD than those with a lower concentration. The adjusted OR was 2.68 (95%CI = 1.44–4.99). The results suggested that mothers whose iron content was 52.95 μg/g or more had a significantly higher risk of having a child with CHD ( aOR = 2.87, 95%CI = 1.54–5.37). No interaction between maternal manganese and iron concentrations was observed in the multiplicative or additive model. The concurrently existing high concentration of manganese and iron may bring higher risk of CHD ( OR = 7.02). Women with excessive manganese concentrations have a significantly increased risk of having offspring with CHDs. The high maternal iron status also correlates with CHDs. The concurrently existing high concentration of manganese and iron may bring higher risk of CHD.

Stability properties of natural estrogen conjugates in different aqueous samples at room temperature and tips for sample storage - Jun Zhang; Yi-ping Wan; Ze-hua Liu; Hao Wang; Zhi Dang; Yu Liu (Environmental Science and Pollution Research, 2022)

Correction to: Spindle‑related brain activation in patients with insomnia disorder: An EEG‑fMRI study - Yan Shao; Guangyuan Zou; Serik Tabarak; Jie Chen; Xuejiao Gao; Ping Yao; Jiayi Liu; Yuezhen Li; Nana Xiong; Wen Pan; Mengying Ma; Shuqin Zhou; et al. (Brain Imaging and Behavior, 2022)

Spindle-related brain activation in patients with insomnia disorder: An EEG-fMRI study - Yan Shao; Guangyuan Zou; Serik Tabarak; Jie Chen; Xuejiao Gao; Ping Yao; Jiayi Liu; Yuezhen Li; Nana Xiong; Wen Pan; Mengying Ma; Shuqin Zhou; et al. (Brain Imaging and Behavior, 2022)

Activated Nrf-2 Pathway by Vitamin E to Attenuate Testicular Injuries of Rats with Sub-chronic Cadmium Exposure - Zhuo Chen; Zhicai Zuo; Kejie Chen; Zhuangzhi Yang; Fengyuan Wang; Jing Fang; Hengmin Cui; Hongrui Guo; Ping Ouyang; Zhengli Chen; Chao Huang; Yi Geng; et al. (Biological Trace Element Research, 2022)

The Predictability of Ocean Environments that Contributed to the 2020/21 Extreme Cold Events in China: 2020/21 La Niña and 2020 Arctic Sea Ice Loss - Fei Zheng; Ji-Ping Liu; Xiang-Hui Fang; Mi-Rong Song; Chao-Yuan Yang; Yuan Yuan; Ke-Xin Li; Ji Wang; Jiang Zhu (Advances in Atmospheric Sciences, 2022)
Several consecutive extreme cold events impacted China during the first half of winter 2020/21, breaking the low-temperature records in many cities. How to make accurate climate predictions of extreme cold events is still an urgent issue. The synergistic effect of the warm Arctic and cold tropical Pacific has been demonstrated to intensify the intrusions of cold air from polar regions into middle-high latitudes, further influencing the cold conditions in China. However, climate models failed to predict these two ocean environments at expected lead times. Most seasonal climate forecasts only predicted the 2020/21 La Niña after the signal had already become apparent and significantly underestimated the observed Arctic sea ice loss in autumn 2020 with a 1–2 month advancement. In this work, the corresponding physical factors that may help improve the accuracy of seasonal climate predictions are further explored. For the 2020/21 La Niña prediction, through sensitivity experiments involving different atmospheric–oceanic initial conditions, the predominant southeasterly wind anomalies over the equatorial Pacific in spring of 2020 are diagnosed to play an irreplaceable role in triggering this cold event. A reasonable inclusion of atmospheric surface winds into the initialization will help the model predict La Niña development from the early spring of 2020. For predicting the Arctic sea ice loss in autumn 2020, an anomalously cyclonic circulation from the central Arctic Ocean predicted by the model, which swept abnormally hot air over Siberia into the Arctic Ocean, is recognized as an important contributor to successfully predicting the minimum Arctic sea ice extent.

Research on Optimal Model of Maritime Search and Rescue Route for Rescue of Multiple Distress Targets - Wen-Chih Ho; Jian-Hung Shen; Chung-Ping Liu; Yung-Wei Chen (Journal of Marine Science and Engineering, 2022)
Coastal countries began to develop green energy, and offshore wind power equipment in coastal areas was gradually built. Since coastal wind power generation often requires carrying out maintenance between wind turbines with the assistance of service operation vessels, this situation may cause coastal areas to be prone to people falling into the water. However, traditional maritime search and rescue plans take a long time to gather information from man overboard incidents. In order to minimize injuries to people in distress, the maritime search and rescue process must be as short as possible. Despite that all the search and rescue plans are based on the concept of the shortest path, the efficient plans must not only consider the distance but also consider the cost of search and rescue. Therefore, this study established a set of practices applicable to the on-site commander (OSC) to dispatch rescue ships, as well as the planning of maritime search and rescue route models. Based on the easy-to-observe state of the target in distress, the model is analyzed and calculated by Floyd–Warshall algorithm and Grey relational analysis so as to sort the rescue plan and optimize the effect of the search and rescue route at sea. According to the simulation analysis, when the man overboard incident occurs in the coastal area, the OSC can immediately use this model to plan the best search and rescue route and dispatch a reasonable number of rescue ships.

Four new resorcinol derivatives with neuroprotective activities from Xylaria nigripes - Lan-Qing Li; Jing Li; Hong-Ping Long; Ji-Kai Liu; Xian Wang (Natural Product Research, 2022)

Potent immunosuppressive and anti-inflammatory bisindole alkaloids from Melodinus fusiformis - Lu Liu; Ming-Jun Xie; Wen-Bing Zhou; Jin-Tang Wang; Jia-Yi Wang; Afsar Khan; Ya-Ping Liu; Jian-Xin Cao; Gui-Guang Cheng; Wen-Yuan Mao (Natural Product Research, 2022)

MKLM: a multiknowledge learning module for object detection in remote sensing images - Sanxing Zhang; Fei Song; Tao Lei; Ping Jiang; Gang Liu (International Journal of Remote Sensing, 2022)

Comparative Analysis of Blood Transcriptome in the Yangtze Finless Porpoise (Neophocaena asiaeorientalis) - Di-An Fang; Kai Liu; Dong-Po Xu; Yin-Ping Wang; Pao Xu (Fishes, 2022)
The Yangtze finless porpoise (Neophocaena asiaeorientalis) is the sole freshwater subspecies of Neophocaenaphocaenoides, and there is a lack of data on its transcriptome. In this study, we applied RNA-seq technology to assemble, de novo, a transcriptome and analyzed differential expressed genes (DEGs). About 6 Gb of clean data was generated for the Yangtze finless porpoise blood (n = 6) through de novo sequencing. In total, 151,211 unigenes were generated and a total of 119,039 of these unigenes (78.72%) were functionally annotated when searched for within the NCBI Nr, SwissProt, GO, COG, and KEGG databases. Diverse and extensive expressed gene catalogs were sampled for the Yangtze finless porpoise. DESeq2 was used to analyze the differential expression genes (DEGs) obtained from the assembled transcriptome. The results indicated that DEGs have close relationships with the Yangtze finless porpoise’s development, evolution and adaptation. Further, we found that genes involved in cetacean TAG synthesis might directly explain the molecular basis of cetacean blubber thickening. These transcriptome data will assist in understanding molecular mechanisms of Yangtze finless porpoise adaptation.

OsMYB103 is essential for tapetum degradation in rice - Ting Lei; Lisha Zhang; Ping Feng; Yang Liu; Wuzhong Yin; Lina Shang; Guanghua He; Nan Wang (Theoretical and Applied Genetics, 2022)

Transcriptomic analyses reveal the effect of nitric oxide on the lateral root development and growth of mangrove plant Kandelia obovata - Ming-Yue Wei; Huan Li; You-Hui Zhong; Zhi-Jun Shen; Dong-Na Ma; Chang-Hao Gao; Yi-Ling Liu; Wen-Hua Wang; Jing-Ya Zhang; Yan-Ping You; Hai-Lei Zheng (Plant and Soil, 2022)

Experimental investigation of propagation and run-up of rockslide- generated impulse waves in a curved mountain reservoir - Linfeng Han; Pingyi Wang; Ping Mu; Qingyang Ren; Yun Liu (Natural Hazards, 2022)

Hippocampal SIRT1-Mediated Synaptic Plasticity and Glutamatergic Neuronal Excitability Are Involved in Prolonged Cognitive Dysfunction of Neonatal Rats Exposed to Propofol - Lin-Hui Ma; Jie Wan; Jing Yan; Ning Wang; Yan-Ping Liu; Hai-Bi Wang; Cheng-Hua Zhou; Yu-Qing Wu (Molecular Neurobiology, 2022)

Activating PIK3CA postzygotic mutations in segmental overgrowth of muscles with bone involvement in the body extremities - Wen Tian; Liying Sun; Qi Zhang; Junhui Zhao; Yang Guo; Wenyao Zhong; Liu Liu; Katia Meirelles; Sha Tang; Jing Zhang; Yingzhao Huang; Yuehan Yin; et al. (Molecular Genetics and Genomics, 2022)

Bioinformatics Analysis of the MicroRNA-Metabolic Gene Regulatory Network in Neuropathic Pain and Prediction of Corresponding Potential Therapeutics - Huai-Gen Zhang; Li Liu; Zhi-Ping Song; Da-Ying Zhang (Journal of Molecular Neuroscience, 2022)

Detection of Microcystin-LR in the Cells and Natural Lake Water Samples by A Unique Fluorescence-Based Method - Yipeng Liu; Bingyan Li; Huixia Zhang; Yong Liu; Ping Xie (Journal of Fluorescence, 2022)

Hydroxysafflor yellow A can improve depressive behavior by inhibiting hippocampal inflammation and oxidative stress through regulating HPA axis - Zhiqiang Liu; Yongzhou Zou; Min He; Ping Yang; Xinhui Qu; Lijun Xu (Journal of Biosciences, 2022)

Association of long-term exposure to ambient air pollution with the number of tuberculosis cases notified: a time-series study in Hong Kong - Man Xu; Ping Hu; Ruoling Chen; Bing Liu; Hongying Chen; Jian Hou; Li ke; Jiao Huang; Hairong Ren; Hui Hu (Environmental Science and Pollution Research, 2022)

Biological monitoring and health assessment of 21 metal(loid)s in children and adolescents in Liuzhou City, Southwest China - Yaping Li; Yu Zhang; Meng Yu; Liqin Hu; Ting Zeng; Ling Liu; Limei Wang; Liangqiong Deng; Xiang Li; Ping Liu; Dingyuan Zeng; Surong Mei (Environmental Science and Pollution Research, 2022)

Correlation assessment of NDVI and land use dynamics with water resources for the southern margin of Mu Us Sandy Land, China - Menglong Zhao; Yu Wang; Siyuan Liu; Ping-an Zhong; Hongzhen Liu; Rongrong Li (Environmental Science and Pollution Research, 2022)

Removal of SO2 from flue gas using blast furnace dust as an adsorbent - Binghua Xie; Na Geng; Qian Yu; Di He; Fang Wang; Tiancheng Liu; Jiyun Gao; Ping Ning; Xin Song; Lijuan Jia (Environmental Science and Pollution Research, 2022)

Is Zooplankton Body Size an Indicator of Water Quality in (Sub)tropical Reservoirs in China? - Li Wang; Jun Chen; Haojie Su; Xufa Ma; Zhixu Wu; Hong Shen; Jia Yu; Jiarui Liu; Yao Wu; Guangyi Ding; Ping Xie (Ecosystems, 2022)

A bi-scale assessing framework for aesthetic ecosystem services of villages in a world heritage site - Yin-ping Ding; Zhi-lin Liu; Yuan-mei Jiao; Qiu-e Xu; Kan-feng Zhang; Cheng-jing Liu; Fan Chen (Journal of Mountain Science, 2022)

MoOpy2 is essential for fungal development, pathogenicity, and autophagy in Magnaporthe oryzae - Ying‐Ying Cai; Jing‐Yi Wang; Xi‐Yu Wu; Shuang Liang; Xue‐Ming Zhu; Lin Li; Jian‐Ping Lu; Xiao‐Hong Liu; Fu‐Cheng Lin (Environmental Microbiology, 2022)
Summary The development and pathogenicity of the fungus Magnaporthe oryzae , the causal agent of destructive rice blast disease, require it to perceive external environmental signals. Opy2, an overproduction‐induced pheromone‐resistant protein 2, is a crucial protein for sensing external signals in Saccharomyces cerevisiae . However, the biological functions of the homologue of Opy2 in M. oryzae are unclear. In this study, we identified that MoOPY2 is involved in fungal development, pathogenicity, and autophagy in M. oryzae . Deletion of MoOPY2 resulted in pleiotropic defects in hyphal growth, conidiation, germ tube extension, appressorium formation, appressorium turgor generation, and invasive growth, therefore leading to attenuated pathogenicity. Furthermore, MoOpy2 participates in the Osm1 MAPK pathway and the Mps1 MAPK pathway by interacting with the adaptor protein Mst50. The interaction sites of Mst50 and MoOpy2 colocalized with the autophagic marker protein MoAtg8 in the preautophagosomal structure sites (PAS). Notably, the Δ Moopy2 mutant caused cumulative MoAtg8 lipidation and rapid GFP‐MoAtg8 degradation in response to nitrogen starvation, showing that MoOpy2 is involved in the negative regulation of autophagy activity. Taken together, our study revealed that MoOpy2 of M. oryzae plays an essential role in the orchestration of fungal development, appressorium penetration, autophagy and pathogenesis.

Endosomal sorting complexes required for transport‐0 ( ESCRT ‐0) are essential for fungal development, pathogenicity, autophagy and ER ‐phagy in Magnaporthe oryzae - Li‐Xiao Sun; Hui Qian; Meng‐Yu Liu; Ming‐Hua Wu; Yun‐Yun Wei; Xue‐Ming Zhu; Jian‐Ping Lu; Fu‐Cheng Lin; Xiao‐Hong Liu (Environmental Microbiology, 2022)
Summary Magnaporthe oryzae is an important plant pathogen that causes rice blast. Hse1 and Vps27 are components of ESCRT‐0 involved in the multivesicular body (MVB) sorting pathway and biogenesis. To date, the biological functions of ESCRT‐0 in M. oryzae have not been determined. In this study, we identified and characterized Hse1 and Vps27 in M. oryzae . Disruption of MoHse1 and MoVps27 caused pleiotropic defects in growth, conidiation, sexual development and pathogenicity, thereby resulting in loss of virulence in rice and barley leaves. Disruption of MoHse1 and MoVps27 triggered increased lipidation of MoAtg8 and degradation of GFP‐MoAtg8, indicating that ESCRT‐0 is involved in the regulation of autophagy. ESCRT‐0 was determined to interact with coat protein complex II (COPII), a regulator functioning in homeostasis of the endoplasmic reticulum (ER homeostasis), and disruption of MoHse1 and MoVps27 also blocked activation of the unfolded protein response (UPR) and autophagy of the endoplasmic reticulum (ER‐phagy). Overall, our results indicate that ESCRT‐0 plays critical roles in regulating fungal development, virulence, autophagy and ER‐phagy in M. oryzae .

The effect of bulk rock composition in phase equilibria modelling: a case study of mafic granulites from the North China Craton - Lei Zou; Jing-Hui Guo; Guang-Yu Huang; Shu-Juan Jiao; Zhong-Hua Tian; Ping-Hua Liu (Contributions to Mineralogy and Petrology, 2022)

A Hydroponic Study on Effect of Zinc Against Mercury Uptake by Triticale: Kinetic Process and Accumulation - Ting Liu; Yi Man; Ping Li; Hua Zhang; Huangxin Cheng (Bulletin of Environmental Contamination and Toxicology, 2022)

Detection of functional and structural brain alterations in female schizophrenia using elastic net logistic regression - Ying Wu; Ping Ren; Rong Chen; Hong Xu; Jianxing Xu; Lin Zeng; Donghui Wu; Wentao Jiang; NianSheng Tang; Xia Liu (Brain Imaging and Behavior, 2022)
Neuroimaging technique is a powerful tool to characterize the abnormality of brain networks in schizophrenia. However, the neurophysiological substrate of schizophrenia is still unclear. Here we investigated the patterns of brain functional and structural changes in female patients with schizophrenia using elastic net logistic regression analysis of resting-state functional magnetic resonance imaging data. Data from 52 participants (25 female schizophrenia patients and 27 healthy controls) were obtained. Using an elastic net penalty, the brain regions most relevant to schizophrenia pathology were defined in the models using the amplitude of low-frequency fluctuations (ALFF) and gray matter, respectively. The receiver operating characteristic analysis showed reliable classification accuracy with 85.7% in ALFF analysis, and 77.1% in gray matter analysis. Notably, our results showed eight common regions between the ALFF and gray matter analyses, including the Frontal-Inf-Orb-R, Rolandic-Oper-R, Olfactory-R, Angular-L, Precuneus-L, Precuenus-R, Heschl-L, and Temporal-Pole-Mid-R. In addition, the severity of symptoms was found positively associated with the ALFF within the Rolandic-Oper-R and Frontal-Inf-Orb-R. Our findings indicated that elastic net logistic regression could be a useful tool to identify the characteristics of schizophrenia -related brain deterioration, which provides novel insights into schizophrenia diagnosis and prediction.

Identification and expression analysis of grape LRK10L-2 genes during grape fruit development - Jin-Ping Ma; Xue-Ren Yin; Tong-Lu Wei; Hai-Nan Liu; Mao-Song Pei; Sheng-Di Yang; Hui-Ying Jin; Guang-Qi He; Da-Long Guo (Plant Biotechnology Reports, 2022)

The settlement intention of urban-to-urban migrants in China: Spatial differences and driving factors - Xinming Wang; Wei Qi; Shenghe Liu; Zhen Liu; Ping Gao; Haoran Jin (Journal of Geographical Sciences, 2022)

Screening of Biological Target Molecules Related to Glucocorticoid-Induced Cataract (GIC) on the Basis of Constructing ceRNA Network - Zhan Shi; Xiumei Zhao; Ying Su; Chao Wang; Ping Liu; Hongyan Ge (Biochemical Genetics, 2022)

SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration - Zuo-long Wu; Ya-jun Chen; Guang-zhi Zhang; Qi-qi Xie; Ke-ping Wang; Xin Yang; Tai-Cong Liu; Zhi-qiang Wang; Guang-hai Zhao; Hai-Hong Zhang (Apoptosis, 2022)

Effects of shading and micro‐spray of canopy on photosynthetic characteristics, quality and yield of drip‐irrigated grapes * - Ming Zheng; Yungang Bai; Jianghui Zhang; Hongbo Liu; Junshe Cai; Shijian Bai; Bangxin Ding; Ping Ding (Irrigation and Drainage, 2022)
Grapes are prone to midday depression of photosynthesis (MDP) under the action of high temperature and strong light, which can reduce the accumulation of organic matter, resulting in a decline in yield and quality. In this study, the grapes in Shanshan County, Xinjiang, China, were taken as an example to implement shading and micro‐spray measures. Shading degrees of 0, 15 and 30% were combined with micro‐spray flow rates of 20, 30 and 40 L h −1 . Nine treatments and one control treatment (the control treatment is without shading and mist spraying) were designed through a combination of the shading and micro‐spray conditions. The photosynthetic prediction model of the multivariate nonlinear model was constructed and had high simulation accuracy. The decline of air temperature at the top of the canopy increased as the degree of shading and the amount of micro‐spray increased; MDP could be eliminated under the combined conditions of shading and micro‐spray. The mean daily net CO 2 assimilation rate (An) increased by more than 0.53 μmol m −2 s −1 . The combination of shading and micro‐spray conditions significantly increased fruit size and promoted greenness. The WP1 (15% and 40 L h −1 ) treatment had the highest mean daily An and the largest fruit volume. The vitamin C (VC) content of WP1 treatment was the highest, 4.13 mg kg −1 , which was 1.2 times that of the control (CK) treatment. The yield of the WP1 treatment was the highest, which was 19.7% higher than that of the CK treatment. Thus, the WP1 treatment was the optimal treatment for promoting the An of grape leaves and improving the fruit quality of grapes. This research could provide a reference for improving the photosynthesis, fruit quality and yield of grapes and alleviating the photosynthetic MDP of crops.

Bias‐corrections on aridity index simulations of climate models by observational constraints - Haipeng Yu; Qiang Zhang; Yun Wei; Chenxi Liu; Yu Ren; Ping Yue; Jie Zhou (International Journal of Climatology, 2022)
Aridity Index (AI) indicates the balance between water supply and water demand on the atmosphere–land interface. Despite continuous improvements, coupled climate models still have significant systematic errors in simulating AI in terms of temporal and spatial variabilities. One of the approaches to bias‐correct simulations is extracting the linear relationship between historical observations and model outputs by utilizing the empirical orthogonal function (EOF). In this study, the methodology of ensemble EOF‐based bias‐correction by observational constraints is developed based on previous bias‐correction approach, with the improvement on seeking the optimal combinations of the leading modes with sensitivity test and replacing the certain correction with the ensemble means of optimal members. In verification, the ensemble mean of Coupled Model Intercomparison Project phase 5 (CMIP5‐EM) is bias‐corrected towards the CPC/GLDAS observations, and the extracted leading modes present high correlations with internal climate variability. By cross‐validation and posteriori independent validation of hindcasts over the historical period (1948–2005), the ensemble EOF‐based bias‐correction could better present spatial patterns compared to the CMIP5‐EM after systematic bias‐correction, as indicated by the anomaly correlation and the root mean square error. The verifications also indicate that the temporal variability in aridity over different dryland regions is much closer to that in the observations and that the dryland subtype changes are improved significantly by bias‐corrections. Besides, another observational dataset of UDel/CRU is applied to assess the uncertainty on different datasets and the improvement on skill scores is robust. The above results verify that the ensemble EOF‐based bias‐corrections provide better reference for assessing and projecting global aridity changes by climate models.

Tropical tall forests are more sensitive and vulnerable to drought than short forests - Liyang Liu; Xiuzhi Chen; Philippe Ciais; Wenping Yuan; Fabienne Maignan; Jin Wu; Shilong Piao; Ying‐Ping Wang; Jean‐Pierre Wigneron; Lei Fan; Pierre Gentine; Xueqin Yang; et al. (Global Change Biology, 2022)
Our limited understanding of the impacts of drought on tropical forests significantly impedes our ability in accurately predicting the impacts of climate change on this biome. Here, we investigated the impact of drought on the dynamics of forest canopies with different heights using time‐series records of remotely sensed Ku‐band vegetation optical depth (Ku‐VOD), a proxy of top‐canopy foliar mass and water content, and separated the signal of Ku‐VOD changes into drought‐induced reductions and subsequent non‐drought gains. Both drought‐induced reductions and non‐drought increases in Ku‐VOD varied significantly with canopy height. Taller tropical forests experienced greater relative Ku‐VOD reductions during drought and larger non‐drought increases than shorter forests, but the net effect of drought was more negative in the taller forests. Meta‐analysis of in situ hydraulic traits supports the hypothesis that taller tropical forests are more vulnerable to drought stress due to smaller xylem‐transport safety margins. Additionally, Ku‐VOD of taller forests showed larger reductions due to increased atmospheric dryness, as assessed by vapor pressure deficit, and showed larger gains in response to enhanced water supply than shorter forests. Including the height‐dependent variation of hydraulic transport in ecosystem models will improve the simulated response of tropical forests to drought.

The Mechanism of Carbonate Alkalinity Exposure on Juvenile Exopalaemon carinicauda With the Transcriptome and MicroRNA Analysis - Kunpeng Shi; Mingdong Li; Zhen Qin; Jiajia Wang; Ping Liu; Jian Li; Jitao Li (Frontiers in Marine Science, 2022)
Saline-alkali water is distributed all over the world and affects the development of fisheries. The ridge tail white prawn Exopalaemon carinicauda is an economically important shrimp in China, which has excellent environmental tolerance. However, due to its complex genetic structure, there have been few studies on its alkalinity-adaptation mechanisms. In order to explore the molecular mechanisms of E. carinicauda in adapting to the alkaline water, mRNA and miRNA transcriptomes from the gills of E. carinicauda were determined. The results showed that after alkalinity stress, the structures of the gill and hepatopancreas were disorganized; however, E. carinicauda could still maintain vital signs. Transcriptome results showed that ATP binding protein and carbonic anhydrase played an important role in alkalinity-adaptation. At the same time, a large number of immune-related genes were up-regulated, which protect E. carinicauda from bacterial infection. MiRNAs also played an important role in alkalinity-adaptation. A total of 24 miRNAs were identified as differentially expressed after alkalinity stress, and up-regulated miRNAs might active the GnRH signaling pathway and accelerate the synthesis and secretion of aldosterone, which might maintain the balance of osmotic pressure in E. carinicauda to adapt to alkaline environment. These results provide a better understanding of the alkalinity-adaptation mechanism of economic aquatic animals and provide theoretical basis for breeding in the future.

Long-Term Ammonia Toxicity in the Hepatopancreas of Swimming Crab Portunus trituberculatus: Cellular Stress Response and Tissue Damage - Yunliang Lu; Jingyan Zhang; Jianwei Cao; Ping Liu; Jian Li; Xianliang Meng (Frontiers in Marine Science, 2022)
Ammonia is the most common contaminant in aquaculture systems. Due to the unexpected deterioration of natural seawater quality caused by harmful alga blooms in summer, the water exchange cycle for the culture ponds of the swimming crab Portunus trituberculatus , an important aquaculture species in China, is often much longer, and the crabs may be exposed to long-term ammonia stress. However, less information is available regarding the long-term effects of ammonia in marine decapod crustaceans. Therefore, it is of great significance to understand the toxic effects of prolonged ammonia in decapods. In this study, alteration of histology, cellular stress responses (CSRs), and apoptosis in the hepatopancreas of P. trituberculatus , an important aquaculture species, during ammonia stress (5, 15, and 45 mg⋅L –1 ) for 1, 7, and 15 days and recovery at the normal condition for 7 days, were analyzed. Our results demonstrated a serious impact of long-term (15 days) ammonia stress by depressing crab CSR especially when ammonia concentration exceeds 15 mg⋅L –1 . Overall, short- (1 day) and medium-term (7 days) ammonia stress induced CSR, evidenced by upregulated expression of the genes involved in antioxidant defense ( SOD , CAT , and GPX ), apoptosis ( p53 , Bax , and Caspase-3 ), heat shock response (HSR) ( Hsp70 and Hsp90 ), unfolded protein response (UPR) ( IRE1 , ATF6 , and XBP1 ), and DNA damage response (DDR) ( ATR and DNA-PKcs ). However, long-term (15 days) ammonia stress, especially when exposed to the ammonia of 15 and 45 mg⋅L –1 , resulted in a higher level of apoptosis and severe damage of hepatopancreas, which may be related to the depressed CSR including antioxidant defense, HSR, UPR, and DDR. Notably, after recovery, the expressions of many genes involved in apoptosis, antioxidant response, HSR, UPR, and DDR in the groups exposed to ammonia at 15 and 45 mg⋅L –1 were still significantly different to that of the control group. In summary, care should be taken when P. trituberculatus is exposed to ammonia over 15 mg⋅L –1 especially when exposure duration is longer than 15 days, as the CSR could be compromised. This study provides a reference for a comprehensive understanding of CSR in decapod crustaceans under ammonia stress and will be beneficial for management in the intensive culture of the swimming crab.

Estimating the added value of GRACE total water storage and uncertainty quantification in seasonal streamflow forecasting - Li Liu; Jingkai Xie; Haiting Gu; Yue-Ping Xu (Hydrological Sciences Journal, 2022)

Discovery of Sex-Determining Genes in Portunus trituberculatus: A Comparison of Male and Female Transcriptomes During Early Developmental Stages - Wen Zhang; Jianjian Lv; Weikang Lan; Baoquan Gao; Ping Liu (Frontiers in Marine Science, 2022)
Portunus trituberculatus is one of the main mariculture crabs of high economic value. To identify genes involved in sex determination, we first performed sex-specific transcriptome sequencing at six larval development stages using a DNA/RNA co-extraction method. A total of 907,952,938 and 828,774,880 reads were obtained from female and male crabs, respectively. 2,379 differentially expressed genes (DEGs) were found between females and males, and were mainly enriched in DNA replication, folate biosynthesis, and retinol metabolism pathways. Furthermore, transcription patterns of genes in the sex-determining region ( SD ) were analyzed based on the transcriptome data, and one Dmrt gene ( PtDMY ) was found to be exclusively expressed in males during early developmental stages. Notably, some known sex-related genes, including IAG, Dmrt11E, DmrtB1 , and DmrtC2 were significantly down-regulated after knocking down PtDMY . Our results suggested that PtDMY is involved in sex determination and may be one of the key upstream regulators of the sex determination pathway. In addition, the massive volume of transcriptome data obtained in this study provided an important basis for the systematic study of sex determination mechanisms in P. trituberculatus .

Seven new glycosides from the leaves of Datura metel L. - Jin-Yan Tan; Yan Liu; Yan-Gang Cheng; Yan-Ping Sun; Xiao-Mao Li; Wei Guan; Juan Pan; Bing-You Yang; Hai-Xue Kuang (Natural Product Research, 2022)

Association of Increased Amygdala Activity with Stress-Induced Anxiety but not Social Avoidance Behavior in Mice - Shou-He Huang; Wei-Zhu Liu; Xia Qin; Chen-Yi Guo; Qing-Cheng Xiong; Yu Wang; Ping Hu; Bing-Xing Pan; Wen-Hua Zhang (Neuroscience Bulletin, 2022)

Design and synthesis of caffeic acid derivatives and evaluation of their inhibitory activity against Pseudomonas aeruginosa - Yun-feng Zeng; Ya-lun Su; Wei-liang Liu; Hong-geng Chen; Shao-gao Zeng; Hai-bo Zhou; Wei-min Chen; Jun-xia Zheng; Ping-hua Sun (Medicinal Chemistry Research, 2022)

Effect of biochar aging on the adsorption and stabilization of Pb in soil - Dandan Chen; Wenhui Liu; Yuxuan Wang; Ping Lu (Journal of Soils and Sediments, 2022)

Cloning of catalase gene and antioxidant genes in Scophthalmus maximus response to metalloprotease of Vibrio anguillarum stress - Hai Ren; Jian Li; Ping Liu; Xianyun Ren; Tao Song; Guisheng Gao; Duwen Li; Shuaiting Liu (Journal of Oceanology and Limnology, 2022)

Scalp Acupuncture Protects Against Neuronal Ferroptosis by Activating The p62-Keap1-Nrf2 Pathway in Rat Models of Intracranial Haemorrhage - Ming-Yue Li; Xiao-Hong Dai; Xue-Ping Yu; Wei Zou; Wei Teng; Peng Liu; Xin-Yang Yu; Qi An; Xin Wen (Journal of Molecular Neuroscience, 2022)
Intracerebral haemorrhage (ICH) can be a catastrophic event; even if the initial stages of the pathology were well-managed, a number of patients experience varied residual neurological deficits following the insult. Ferroptosis is a recently identified type of cell demise which is tightly linked to the neurological impairment associated with ICH. In the current work, the prophylactic impact of scalp acupuncture (SA) therapy on autologous blood injection murine models of ICH was investigated in order to establish whether SA could mitigate the secondary damage arising following ICH by moderating ferroptosis. The pathophysiological mechanisms associated with this process were also explored. Ludmila Belayev tests were utilised for the characterisation of neurological damage. Haematoxylin–eosin staining was employed in order to determine the cerebral impact of the induced ICH. Malondialdehyde (MDA) and iron titres in peri-haemorrhagic cerebral tissues were appraised using purchased assay kits. Transmission electron microscopy delineated mitochondrial appearances within nerve cell bodies from the area of haemorrhage. Western blotting techniques were utilised to assay the degree of protein expression of NeuN, sequestosome 1 (p62), nuclear factor erythroid 2-related factor 2 (Nrf2), Kelch-like ECH-associated protein 1 (Keap1), glutathione peroxidase 4 (GPX4) and ferritin heavy chain 1 (FTH1). The frequencies of Nrf2, GPX4 and FTH1 positive cells, respectively, were documented with immunohistochemical staining. The results demonstrated that therapy with SA after ICH mitigated MDA and iron sequestration, diminished the appearance of contracted mitochondria with increased outer mitochondrial membrane diameter within the nerve cell bodies, and suppressed neuronal ferroptosis. The pathways responsible for these effects may encompass amplified p62, Nrf2, GPX4 and FTH1 expression, together with decreased Keap1 expression. Application of SA reduced identified neurobehavioural abnormalities after ICH; no disparities were observed between the consequences of SA therapy and deferoxamine delivery. It can be surmised that intervention with SA enhanced recovery after ICH by triggering the antioxidant pathway, p62/Keap1/Nrf2, and causing FTH1 and GPX4 upregulation, factors that participate in diminishing excess iron and thus in mitigating lipid peroxidation insults arising from ferroptosis following ICH.

Endophytes Bacillus amyloliquefaciens AW3 (CGMCC1.16683) improves the growth of Populus davidiana × Populus bolleana (PdPap) and induces its resistance to wilt disease by Fusarium oxysporum Fox68 (CFCC86068) - Ping Zhang; Haotian Hao; Lihai Wang; Zhihua Liu; Ling Ma (European Journal of Plant Pathology, 2022)

Genetic improvement of grain quality traits in indica inbred rice cultivars developed in South China during 1956–2020 - Xin-Qiao Zhou; Da-Gang Chen; Jie Guo; Ping-Li Chen; Li-Jun Li; Ke Chen; You-Ding Chen; Chuan-Guang Liu; Ze-Min Zhang (Euphytica, 2022)

C-dot doping for enhanced catalytic performance of TiO2/5A for toluene degradation in non-thermal plasma-catalyst system - Jixing Liu; Yanyan Ji; Shuping Zhu; Teng Guo; Li Xu; Junguo Dong; Ping Cheng (Environmental Science and Pollution Research, 2022)

Fracture analysis of central-flawed rock-like specimens under the influence of coplanar or non-coplanar edge flaws - Zhizhen Liu; Ping Cao; Kaihui Li; Fei Wang; Tao Dong; Jingshuo Liu (Bulletin of Engineering Geology and the Environment, 2022)

Subproteomic profiling from renal cortices in OLETF rats reveals mutations of multiple novel genes in diabetic nephropathy - Zhiguo Li; Hong Shen; Yeqiang Liu; Xuefeng Zhou; Meihua Yan; Hailan He; Tingting Zhao; Haojun Zhang; Ping Li (Genes & Genomics, 2022)

Mitogenomes provide new insights into the evolutionary history of Prodiamesinae (Diptera: Chironomidae) - Xiao‐Long Lin; Yan‐Min Zhao; Li‐Ping Yan; Wen‐Bin Liu; Wen‐Jun Bu; Xin‐Hua Wang; Chen‐Guang Zheng (Zoologica Scripta, 2022)
Evolutionary analysis of Prodiamesinae has long been impeded by lack of information, and its phylogenetic relationship with Orthocladiinae remains questionable. Here, ten complete mitochondrial genomes (mitogenomes) of Orthocladiinae sensu lato were newly sequenced, including three Prodiamesinae species and seven Orthocladiinae species. Coupled with published mitogenomes, a total of 12 mitogenomes of Orthocladiinae sensu lato were selected for a comparative mitogenomic analysis and phylogenetic reconstruction. Mitogenomes of Orthocladiinae sensu lato are conserved in structure, and all genes arrange the same gene order as the ancestral insect mitogenome. Nucleotide composition is highly biased, and the control region displayed the highest A + T content. All protein‐coding genes are under purifying selection, and the ATP8 evolves at the fastest rate. In addition, the mitogenomes of Orthocladiinae sensu lato are highly conserved, and they are practically useful for phylogenetic inference, suggesting a re‐classification of Orthocladiinae by sinking Prodiamesinae as a subgroup of Orthocladiinae.

Biogeography of culturable marine bacteria from both poles reveals that ‘everything is not everywhere’ at the genomic level - Qi‐Long Qin; Zhi‐Bin Wang; Qian‐Qian Cha; Sha‐Sha Liu; Xue‐Bing Ren; Hui‐Hui Fu; Mei‐Ling Sun; Dian‐Li Zhao; Andrew McMinn; Yin Chen; Xiu‐Lan Chen; Yu‐Zhong Zhang; et al. (Environmental Microbiology, 2022)
Summary Based on 16S rRNA gene analyses, the same bacterial operational taxonomic units (OTUs) are common to both the Arctic and Antarctic oceans, supporting the concept ‘everything is everywhere’. However, whether the same OTUs from both poles have identical genomes, i.e. whether ‘everything is still everywhere’ at the genomic level has not yet been examined systematically. Here, we isolated, sequenced and compared the genomes of 45 culturable marine bacteria belonging to three genera of Salinibacterium , Psychrobacter and Pseudoalteromonas from both polar oceans. The bacterial strains with identical 16S rRNA genes were common to both poles in every genus, and four identical genomes were detected in the genus Salinibacterium from the Arctic region. However, no identical genomes were observed from opposite poles in this study. Our data, therefore, suggest that ‘everything is not everywhere’ at the genomic level. The divergence time between bacteria is hypothesized to exert a strong impact on the bacterial biogeography at the genomic level. The geographical isolation between poles was observed for recently diverged, highly similar genomes, but not for moderately similar genomes. This study thus improves our understanding of the factors affecting the genomic‐level biogeography of marine microorganisms isolated from distant locations.

Physiological and Molecular Responses in the Gill of the Swimming Crab Portunus trituberculatus During Long-Term Ammonia Stress - Jingyan Zhang; Mengqian Zhang; Nishad Jayasundara; Xianyun Ren; Baoquan Gao; Ping Liu; Jian Li; Xianliang Meng (Frontiers in Marine Science, 2021)
Ammonia is a common environmental stressor encountered during aquaculture, and is a significant concern due to its adverse biological effects on vertebrate and invertebrate including crustaceans. However, little information is available on physiological and molecular responses in crustaceans under long-term ammonia exposure, which often occurs in aquaculture practices. Here, we investigated temporal physiological and molecular responses in the gills, the main ammonia excretion organ, of the swimming crab Portunus trituberculatus following long-term (4 weeks) exposure to three different ammonia nitrogen concentrations (2, 4, and 8 mg l –1 ), in comparison to seawater (ammonia nitrogen below 0.03 mg l –1 ). The results revealed that after ammonia stress, the ammonia excretion and detoxification pathways were initially up-regulated. These processes appear compromised as the exposure duration extended, leading to accumulation of hemolymph ammonia, which coincided with the reduction of adenosine 5′-triphosphate (ATP) and adenylate energy charge (AEC). Considering that ammonia excretion and detoxification are highly energy-consuming, the depression of these pathways are, at least partly, associated with disruption of energy homeostasis in gills after prolonged ammonia exposure. Furthermore, our results indicated that long-term ammonia exposure can impair the antioxidant defense and result in increased lipid peroxidation, as well as induce endoplasmic reticulum stress, which in turn lead to apoptosis through p53-bax pathway in gills of the swimming crab. The findings of the present study further our understanding of adverse effects and underlying mechanisms of long-term ammonia in decapods, and provide valuable information for aquaculture management of P. trituberculatus .