Complete genome analysis of a novel chuvirus from a southern green stink bug (Nezara viridula) - Peng-Peng Ren; Zhuang-Xin Ye; Sai-Nan Wang; Jun-Min Li; Jian-Ping Chen; Chuan-Xi Zhang; Jia-Bao Lu (Archives of Virology, 2022)

Paenibacillus hamazuiensis sp. nov., a bacterium isolated from Hamazui hot spring in Yunnan province, south-west China - Juan Wang; Ming Deng; En-Min Zhou; Lei Ran; Cui-Ping Miao; Yi-Qing Li; Jun-Mei Ding; Shu-Kun Tang (Archives of Microbiology, 2022)

Theoretical analysis on influence factors of anchor cable internal force under over-excavation considering earth berm - Jiayong Lin; Feicong Zhou; Wenhao Fan; Mao Chen; Jinyi Li; Yifan Jiang; Ming Lin; Ping Zhou; Zhijie Wang (Arabian Journal of Geosciences, 2022)

Adaptive Proportional-Integral Sliding Mode-Based Fault Tolerant Control for Autonomous Underwater Vehicles with Thrusters Saturation and Potential Failure - Jian Xu; Xing Wang; Ping Liu; Qiaoyu Duan (Journal of Marine Science and Engineering, 2022)
This paper focuses on the fault tolerant control of autonomous underwater vehicles (AUVs) in the presence of dynamic uncertainties and potential thruster failure issues. For this, an adaptive proportional-integral sliding mode-based fault tolerant control (APISM-FTC) is proposed to drive the AUV to follow the desired trajectory, in the event of unknown thrusters failure and thrusters saturation. Radial basis function neural network (RBFNN) and an adaptive approach are used to evaluate the dynamics uncertainty during the construction of the APISM-FTC controller. To guarantee that all tracking errors asymptotically converge to zero, a comprehensive theoretical analysis and mathematical proof based on Lyapunov stability analysis are implemented. The simulation experiments on two fault conditions are carried out, respectively, and the control effects under normal conditions are compared. It can be shown that the designed APISM-FTC method can make the system reach a stable state quickly, and can still have a good control performance in the case of the failure of the thruster.

Association between short-term exposure to ambient air pollution and number of outpatient Helicobacter pylori infection visits - Lizuo Ma; Zhijing Lin; Jiaoxue Wang; Ruirui Ye; Yuefang Li; Ping Chen; Zhi Yuan; Liyan Yang; Lin Miao; Jiehua Li (Environmental Science and Pollution Research, 2022)

Metabolomic analysis reveals the impact of ketoprofen on carbon and nitrogen metabolism in rice (Oryza sativa L.) seedling leaves - Huan Wang; Zhiheng Li; Hanmei Chen; Jiaojun Jin; Ping Zhang; Luoqin Shen; Shuhao Hu; Huijun Liu (Environmental Science and Pollution Research, 2022)

Isolation, identification, and quantification of triterpene saponins in the fresh fruits of Panax notoginseng - Zheng-yi Qu; He-cheng Wang; Yin-ping Jin; Ya-li Li; Ying-ping Wang (Natural Product Research, 2022)

EST-SSR marker-based investigation on genetic diversity and genetic structure of Juglans mandshurica Maxim. in Shandong Province of China - Zihao Wang; Hao Zhang; Boqiang Tong; Biao Han; Dan Liu; Ping Zhang; Dechang Hu (Genetic Resources and Crop Evolution, 2022)

Comparative transcriptomic analysis and validation of the ovary and testis in the ridgetail white prawn (Exopalaemon carinicauda) - Shaoting Jia; Ling Jin; Jianjian Lv; Jiajia Wang; Jitao Li; Ping Liu; Jian Li (Frontiers in Marine Science, 2022)
The ridgetail white prawn, Exopalaemon carinicauda is an important cultured seawater species in China. As female E.carinicauda grows faster than males, it is significant to search for the differentially expressed genes (DEGs) between males and females. However, there is no public available E.carinicauda genome data, and genes related to E. carinicauda sex differences are unclear. In this study, the transcriptome sequencing for ovary and testis tissues of E. carinicauda were conducted, and 20,891 DEGs were identified including 11,709 up-regulated DEGs and 9,182 downregulated DEGs. The functional categories related to meiosis and reproduction were enriched as well as the steroidogenesis KEGG pathway was clustered. Furthermore, the genes related to male reproduction and cell cycle were dug out which were verified by real-time PCR. In addition, two-color fluorescent in situ hybridization result showed that foxj1b might play roles during early stage of the ovary development. Therefore, our result provides clues for the study of genes related to reproduction and sex difference in E.carinicauda .

Evaluation and prediction of land use change impacts on ecosystem service values in Nanjing City from 1995 to 2030 - Ping Yu; Shuainan Zhang; Peng Wang; Yingnan Li; Lei Huang (Environmental Science and Pollution Research, 2022)

Four new secoiridoids from the stem barks of Syringa reticulata (Bl.) Hara - Shuang Guo; Yan Liu; Yan-Ping Sun; Juan Pan; Wei Guan; Xiao-Mao Li; Si-Yi Wang; Adnan Mohammed Algradi; Bing-You Yang; Hai-Xue Kuang (Natural Product Research, 2022)

Study on the Effectiveness and Mechanism of Mercapto-Modified Attapulgite for Remediation of Cadmium-Contaminated Paddy Soil - Guangxi He; Xiaping Zhu; Yan An; Yuying Chen; Cheng Fu; Ningfei Lei; Ying Zeng; Junya Li; Zepeng Wang; Ping Zhao (Water, Air, & Soil Pollution, 2022)

Petrology and geochemistry of the Carboniferous cutinite-rich coals from the Hequ area of Shanxi Province, China - Daofu Song; Tieguan Wang; Ping Li; Jiadong Yan; Xiangji Zheng (Science China Earth Sciences, 2022)

Improving pre-harvest sprouting resistance in rice by editing OsABA8ox using CRISPR/Cas9 - Kai Fu; Weihan Song; Cheng Chen; Changling Mou; Yunshuai Huang; Fulin Zhang; Qixian Hao; Ping Wang; Tengfei Ma; Yaping Chen; Ziyan Zhu; Min Zhang; et al. (Plant Cell Reports, 2022)

Depletion of serum-derived exosomes aggravates heat stress-induced damage of bovine mammary epithelial cells - Yue Wang; Hui-Li Wang; Zhi-Ping Lin; Ji-Feng Zhong; Kun-Lin Chen; Xing Duan (Molecular Biology Reports, 2022)

Enhanced M-CSF/CSF1R Signaling Closely Associates with PrPSc Accumulation in the Scrapie-Infected Cell Line and the Brains of Scrapie-Infected Experimental Rodents - Ying Xia; Cao Chen; Jia Chen; Chao Hu; Wei Yang; Lin Wang; Lian Liu; Li-Ping Gao; Yue-Zhang Wu; Dong-Dong Chen; Qi Shi; Zhi-Bao Chen; et al. (Molecular Neurobiology, 2022)

iTRAQ-based proteomics analysis of diethylstilbestrol induced dysfunction of testicular gubernaculum development in mouse - Hongyan Ping; Degang Wang; Maxian Fu; Kaihong Chen; Jiuhong Zhang; Ke Li; Xuewu Jiang; Shouxing Duan; Xuan Zhang (Molecular & Cellular Toxicology, 2022)

Spatial distribution, food chain translocation, human health risks, and environmental thresholds of heavy metals in a maize cultivation field in the heart of China’s karst region - Wentao Yang; Yonglin Chen; Liyu Yang; Mengqi Xu; Haonan Jing; Pan Wu; Ping Wang (Journal of Soils and Sediments, 2022)

Correction to: Physiological Mechanism of Drought-Resistant Rice Coping With Drought Stress - Benfu Wang; Xiaolong Yang; Liang Chen; Yuanyuan Jiang; Hongying Bu; Yang Jiang; Ping Li; Cougui Cao (Journal of Plant Growth Regulation, 2022)

Physiological Mechanism of Drought-Resistant Rice Coping With Drought Stress - Benfu Wang; Xiaolong Yang; Liang Chen; Yuanyuan Jiang; Hongying Bu; Yang Jiang; Ping Li; Cougui Cao (Journal of Plant Growth Regulation, 2022)

Distinguishing the determinative landscape factors influencing the spatial variation of soil quality in Chongming Island, China - Yubing Qu; Yuan Chi; Jianhua Gao; Xuejian Ma; Ya Ping Wang (Journal of Coastal Conservation, 2022)

Comparative transcriptome analyses identify genes involved into the biosynthesis of forsythin and forsythoside A in Forsythia suspensa - Wang Jun Yuan; Su Ping Zhang; Zhi Yin He; Yan Xia He; She Qi He; Li Jun Liu; Xin Sun; Qin Li (Functional & Integrative Genomics, 2022)

Effect of posaconazole on the concentration of intravenous and oral cyclosporine in patients undergoing hematopoietic stem cell transplantation - Li-E Zhu; Hui-Ping Huang; Yi-Peng Cai; Yan Wang; Bao-Hua Xu; Mao-Bai Liu; Xue-Mei Wu (European Journal of Clinical Pharmacology, 2022)

Responses of grassland ecosystem carbon fluxes to precipitation and their environmental factors in the Badain Jaran Desert - Ping Yang; Nai’ang Wang; Liqiang Zhao; Bingjie Su; Zhenmin Niu; Hang Zhao (Environmental Science and Pollution Research, 2022)

Methods to control harmful algal blooms: a review - Barathan Balaji-Prasath; Ying Wang; Yu Ping Su; David P. Hamilton; Hong Lin; Luwei Zheng; Yong Zhang (Environmental Chemistry Letters, 2022)

Oceanobacillus saliphilus sp. nov., Isolated from Saline−Alkali Soil in Heilongjiang Province, China - Yu-Ting OuYang; Meng-Meng Li; Ai-Ping Lv; Pin-Jiao Jin; Lan Liu; Ze-Tao Liu; Jian-Yu Jiao; Wen-Jun Li; Li-Xiang Cao; Shuang Wang (Current Microbiology, 2022)

The eastward expansion of the climate humidification trend in northwest China and the synergistic influences on the circulation mechanism - Qiang Zhang; Jinhu Yang; Xinyu Duan; Pengli Ma; Guoyang Lu; Biao Zhu; Xiaoyun Liu; Ping Yue; Youheng Wang; Weiping Liu (Climate Dynamics, 2022)

Biases and improvements of the ENSO-East Asian winter monsoon teleconnection in CMIP5 and CMIP6 models - Wenping Jiang; Hainan Gong; Ping Huang; Lin Wang; Gang Huang; Lisuo Hu (Climate Dynamics, 2022)

Associations of Serum Calcium, Magnesium Levels, and Their Ratio with Apolipoproteins in Chinese Adults with Coronary Artery Disease: a Cross-Sectional Study - Hongli Dong; Ping Hu; Jie Wang; Yaju Zhang; Nan Lu (Biological Trace Element Research, 2022)

Characteristics of timberline and treeline altitudinal distribution in Mt. Namjagbarwa and their geographical interpretation - Hao-xiang Mu; Fang Han; Bai-ping Zhang; Tian Liang; Zhi-yong Wang; Zhe Wang (Journal of Mountain Science, 2022)

Complete genome analysis of a novel iflavirus from the spotted lanternfly Lycorma delicatula - Yi-Zhe Wang; Zhuang-Xin Ye; Jian‑Ping Chen; Chuan‑Xi Zhang; Jun‑Min Li; Hai-Jian Huang (Archives of Virology, 2022)

Molecular characterization of a novel double-stranded RNA virus infecting the entomopathogenic fungus Metarhizium brunneum - Ping Wang; Guogen Yang; Najie Shi; Bo Huang (Archives of Microbiology, 2022)

Food web and metabolic interactions of the lung inhabitants Streptococcus pneumoniae and Pseudomonas aeruginosa - Wael Sabra; Wei Wang; Christiane Goepfert; An‐Ping Zeng (Environmental Microbiology, 2022)
Bacteria that successfully adapt to different substrates and environmental niches within the lung and overcome the immune defence can cause serious lung infections. Such infections are generally complex, and recognized as polymicrobial in nature. Both Pseudomonas aeruginosa and Streptococcus pneumoniae can cause chronic lung infections and were both detected in cystic fibrosis (CF) lung at different stages. In this study, single and dual species cultures of Pseudomonas aeruginosa and Streptococcus pneumoniae were studied under well‐controlled planktonic growth conditions. Under pH‐controlled conditions, both species apparently benefited from the presence of the other. In co‐culture with P . aeruginosa , S . pneumoniae grew efficiently under aerobic conditions, whereas in pure S . pneumoniae culture, growth inhibition occurred in bioreactors with dissolved oxygen concentrations above the microaerobic range. Lactic acid and acetoin that are produced by S . pneumoniae were efficiently utilized by P . aeruginosa . In pH‐uncontrolled co‐cultures, the low pH triggered by S . pneumoniae assimilation of glucose and lactic acid production negatively affected the growth of both strains. Nevertheless, ammonia production improved significantly, and P . aeruginosa growth dominated at later growth stages. This study revealed unreported metabolic interactions of two important pathogenic microorganisms and shed new lights into pathophysiology of bacterial lung infection.

The evolutionary characteristics and influencing factors of total carbon productivity: evidence from China - Shengnan Cui; Yanqiu Wang; Ping Xu; Zhiwei Zhu (Environmental Science and Pollution Research, 2022)

Functional analysis of HADH c.99C>G shows that the variant causes the proliferation of pancreatic islets and leu-sensitive hyperinsulinaemia - Wu Long; Yue-Bing Wang; Peng-Fei Qu; Lin Ma; Si-Jie Wei; Yan-Mei Xi; Jin-Liang Du; Xue Tang; Kai Liu; Yu-Hua Li; Pu-Ping Lei (Journal of Genetics, 2022)

Evaluating the performance of hydrological models with joint multifractal spectra - Zhixu Bai; Yue-Ping Xu; Suli Pan; Li Liu; Zixia Wang (Hydrological Sciences Journal, 2022)

Overexpression of PYGO1 promotes early cardiac lineage development in human umbilical cord mesenchymal stromal/stem cells by activating the Wnt/β-catenin pathway - Jie Shen; Xiushan Wu; Ping Zhu; Jian Zhuang; Bin Qin; Fang Sun; Wuzhou Yuan; Xiongwei Fan; Zhigang Jiang; Fang Li; Yongqing Li; Yuequn Wang; et al. (Human Cell, 2022)

Correlation analysis of migration in Eriocheir sinensis of the Yangtze River estuary based on salinity preference - Chenchen Shen; Ruifang Wang; Guangpeng Feng; Ping Zhuang; Tao Zhang; Xiaorong Huang (Environmental Science and Pollution Research, 2022)

Early Carboniferous high-silica granites in the Kalejun Mountains, Chinese western Tianshan: Petrogenesis, tectonic setting and geodynamic implications for the South Tianshan Ocean - Yaoqing Luo; Yongjun Li; Zuopeng Wang; Gaoxue Yang; Ping Shen; Mingyao Teng; Weining Wang; Haoying Chang (International Geology Review, 2022)

A Hierarchical Index System for Analysis of Water Supply-Demand Situation - Ting Wang; Jinjun You; Zhenzhen Ma; Ping Xiao (Water Resources Management, 2022)

Sevoflurane exposure during the second trimester induces neurotoxicity in offspring rats by hyperactivation of PARP-1 - Cong Wang; Qian Jiang; Ping Zhao (Psychopharmacology, 2022)

Genetic Control of the Root System Traits in Oilseed Rape Under Contrasting Phosphate Supply Conditions by Genome-wide Association Study - Ping Xu; Xiaohua Wang; Hui Li; Shengjie Dai; Xue Cao; Zhenning Liu (Plant Molecular Biology Reporter, 2022)

Feasibility Studies of Nebulized SARS-CoV-2 Neutralizing Antibody in Mice and Cynomolgus Monkeys - Jilei Jia; Zhaojuan Yin; Xiao Zhang; Huimin Li; Dan Meng; Qianqian Liu; Hongfang Wang; Meng Han; Shixiang Suo; Yan Liu; Ping Hu; Chunyun Sun; et al. (Pharmaceutical Research, 2022)
Purpose Neutralizing antibodies, administrated through intravenous infusion, have shown to be highly efficacious in treating mild and moderate COVID-19 caused by SARS-CoV-2 infection in the lung. However, antibodies do not transport across the plasma-lung barrier efficiently, and up to 100 mg/kg dose was used in human causing significant supply and cost burdens. This study was to explore the feasibility of nebulized antibodies inhalation delivery as an alternative route. Methods HB27, a potent RBD-specific humanized monoclonal antibody (Zhu et al. in National Sci Rev. 8:nwaa297, 2020), showed excellent protection against SARS-CoV-2 in animal model and good safety profile in clinical studies. The pharmacokinetics and preliminary safety of HB27 administrated through the respiratory tract were studied in mice and cynomolgus monkeys here. Results At a single 5 mg/kg dose, the peak HB27 concentration in mice pulmonary epithelial lining fluid (ELF) reached 857.8 μg/mL, 670-fold higher than the PRNT 90 value of 1.28 μg/mL, and maintained above PRNT 90 over 240 h. In contrast, when administrated by intravenous injection at a 5 mg/kg dose, the antibody concentrations in mice ELF were below PRNT 90 value throughout, and were about 50-fold lower than that in the serum. In cynomolgus monkeys administrated with a single dose through inhalation, the antibody concentration in ELF remained high within 3 days. No drug-related safety concerns were observed in the studies. Conclusions The study demonstrated that nebulized neutralizing antibody delivery though inhalation could be a more efficient and efficacious alternative approach for treating COVID-19 and other respiratory infectious diseases, and warrants further evaluation in clinical studies.

Novel circularRNA circ-0047078 promotes pancreatic ductal adenocarcinoma progression through mircoRNA miR-11181— Chemokine (C-X-C motif) Ligand 12/Melanoma Cell Adhesion Molecule/Regulator of G-protein signaling 16 pathway - Yuzhou Wang; Hangwei Fu; Yan Jiang; Bo Zhou; Ping Chen (Molecular Biology Reports, 2022)

WASHC1 interacts with MCM2-7 complex to promote cell survival under replication stress - Yu Hong; He Sun; Xian Hong; Cai-Ping Yang; Daniel D. Billadeau; Tao Wang; Zhi-Hui Deng (Molecular Biology Reports, 2022)

Knockdown of UCA1 attenuated the progression of alcoholic fatty disease by sponging miR-214 - Huali Xiang; Binfeng Tu; Ming Luo; Ping Hou; Jiakun Wang; Rongguiyi Zhang; Linquan Wu (Mammalian Genome, 2022)

Lean Stability Approaches in Pharmaceutical Product Development, Registration, and Post-marketing CMC Change Management; Industry Survey Insights - Donnie Pulliam; Megan McMahon; Brian P. Regler; Susan Smith; Cheryl Martin; Yelizaveta Babayan; Cherokee Hoaglund-Hyzer; Michael Lesslie; Fenghe Qiu; Eric Adamec; Jin Wang; Pat Forenzo; et al. (Journal of Pharmaceutical Innovation, 2022)
Purpose This paper summarizes results from a recent pharmaceutical industry survey to understand the adoption status of science- and risk-based approaches in pharmaceutical stability (lean stability) in regulatory submissions across the full pharmaceutical product life cycle and to ascertain whether companies are deriving their stability strategies based on scientific risk or applying generic strategies. Methods A comprehensive survey was distributed to pharmaceutical companies affiliated with the International Consortium for Innovation and Quality in Pharmaceutical Development (IQ Consortium) to solicit non-proprietary responses pertaining to regulatory strategies for stability monitoring across the product life cycle, perceived risks, and health authority feedback. Results Among the 19 responding companies, utilization of lean stability approaches varied with respect to (1) phase of product life cycle, (2) specific product quality attributes cited in effective ICH guidances or which demonstrated shelf-life limiting stability trends, and (3) the degree of perceived risk of rejection by health authorities based upon companies’ degree of experience from previous regulatory submissions. Conclusion Continued collaboration between the pharmaceutical industry and health authorities—through case studies and revision/harmonization of regulatory guidances—will be essential for continued implementation of lean stability strategies to accelerate delivery of innovative medicines to the clinic and to the market.

Dissecting the role of cell signaling versus CD8+ T cell modulation in propranolol antitumor activity - Wei Li; Jielin Wan; Cuiyu Chen; Chengfang Zhou; Ping Liao; Qian Hu; Jiali Hu; Yang Wang; Yu Zhang; Cong Peng; Yuanfei Huang; Weihua Huang; et al. (Journal of Molecular Medicine, 2022)

Influence of microplastics on triclosan bioaccumulation and metabolomics variation in Tilapia fish tissues - Yu-Wei Jia; Ping Wang; Sheng Yang; Zheng Huang; Yue-Hong Liu; Jian-Liang Zhao (Environmental Science and Pollution Research, 2022)

Effects of biochar and chemical fertilizer amendment on diazotrophic abundance and community structure in rhizosphere and bulk soils - Ziting Zhao; Yanshu Zhang; Ping Sun; Qing Wang; Yunze Ruan (Environmental Science and Pollution Research, 2022)

Xinfangfangia pollutisoli sp. nov., Isolated from Clopyralid-Contaminated Soil - Yang Mu; Jia-Yi Peng; Hui-Ping Wang; Yue Song; Hong-Mei Wang; Qing Chen; Kai Chen (Current Microbiology, 2022)

Evaluation of the microwave-assisted organic acid separation of organic sulfur from high-sulfur coal - Jin Liu; Chaoshun Jiang; Hao Shen; Zheng Pang; Zhi Wang; Ping Li; Xing Xing (Clean Technologies and Environmental Policy, 2022)

Development and Validation of a Diagnostic Nomogram to Predict the Anthracycline-Induced Early Cardiotoxicity in Children with Hematological Tumors - Zhi-yuan Liu; Yun-gong Wang; Xiao-bi Huang; Xiao-hui Qi; Cui-ping Qian; Sheng Zhao (Cardiovascular Toxicology, 2022)
This study aimed to establish and validate an effective nomogram to predict the risk of cardiotoxicity in children after each anthracycline treatment. According to the inclusion and exclusion criteria, the eligible children were randomly divided into the training cohort (75%) and the validation cohort (25%). Least absolute shrinkage and selection operator (LASSO) regression was used to select the predictors and a nomogram was developed. Then, concordance index ( C -index), the area under the curve (AUC), Hosmer–Lemeshow (H–L) test, and decision curve analysis (DCA) were employed to evaluate the performance and clinical utility of nomogram. Internal validation was processed to inspect the stability of the model. A total of 796 eligible children were included in this study and divided into a training set ( n = 597) and a validation set ( n = 199). LASSO regression analysis revealed that cumulative anthracycline dose, ejection fractions, NT-proBNP, and diastolic dysfunction were effective predictors of cardiotoxicity. The nomogram was established based on these variables. The C -index and the AUC of the predicting nomogram were 0.818 in the training cohort and 0.773 in the validation cohort, suggesting that the nomogram had good discrimination. The calibration curve of the nomogram presented no significant deviation from the reference line, and the P -value of the H–L test was 0.283, implying a preferable degree of calibration. The threshold of DCA also reflects that the nomogram is clinically useful. A nomogram was developed to predict anthracycline chemotherapy-induced cardiotoxicity in children with hematological tumors. The nomogram has a good prediction effect and can provide a reference for clinicians’ diagnosis and treatment.

Impacts of Mercury Exposure Levels and Sources on the Demethylation of Methylmercury Through Human Gut Microbiota - Xian-Feng Yang; Shao-Chen Yang; Fu-Li Wen; Lin Feng; Bo Meng; Hai-Yan Hu; Bao-Lin Wang; Jun Li; Alexandre J. Poulain; Ping Li (Bulletin of Environmental Contamination and Toxicology, 2022)

Visual Monitoring of Disintegration of Solid Oral Dosage Forms in Simulated Gastric Fluids Using Low-Field NMR Imaging - Qianyu Ye; Meilai Ding; Ping Zhang; Peng Wu; Yong Wang; Cordelia Selomulya; Xiao Dong Chen (AAPS PharmSciTech, 2022)

Global evaluation of inhibitor impacts on ammonia and nitrous oxide emissions from agricultural soils: A meta‐analysis - Daijia Fan; Wentian He; Ward N. Smith; Craig F. Drury; Rong Jiang; Brian B. Grant; Yaoyao Shi; Daping Song; Yanhua Chen; Xuexia Wang; Ping He; Guoyuan Zou (Global Change Biology, 2022)
Inhibitors are widely considered an efficient tool for reducing nitrogen (N) loss and improving N use efficiency, but their effectiveness is highly variable across agroecosystems. In this study, we synthesized 182 studies (222 sites) worldwide to evaluate the impacts of inhibitors (urease inhibitors [UI], nitrification inhibitors [NI] and combined inhibitors) on crop yields and gaseous N loss (ammonia [NH 3 ] and nitrous oxide [N 2 O] emissions) and explored their responses to different management and environmental factors including inhibitor application timing, fertilization regime, cropping system, water management, soil properties and climatic conditions using subgroup meta‐analysis, meta‐regression and multivariate analyses. The UI were most effective in enhancing crop yields (by 5%) and reducing NH 3 volatilization (by 51%), whereas NI were most effective at reducing N 2 O emissions (by 49%). The application of UI mitigates NH 3 loss and increases crop yields especially in high NH 3 ‐N loss scenarios, whereas NI application would minimize the net N 2 O emissions and the resultant environmental impacts especially in low NH 3 ‐N loss scenarios. Alternatively, the combined application of UI and NI enables producers to balance crop production and environmental conservation goals without pollution tradeoffs. The inhibitor efficacy for decreasing gaseous N loss was dependent upon soil and climatic conditions and management practices. Notably, both meta‐regression and multivariate analyses suggest that inhibitors provide a greater opportunity for reducing fertilizer N inputs in high‐N‐surplus systems and presumably favor crop yield enhancement under soil N deficiency situations. The pursuit of an improved understanding of the interactions between plant‐soil‐climate‐management systems and different types of inhibitors should continue to optimize the effectiveness of inhibitors for reducing environmental losses while increasing productivity.

Oxytocin Receptor in Cerebellar Purkinje Cells Does Not Engage in Autism-Related Behaviors - Li-Ping Shen; Wei Li; Ling-Zhu Pei; Jun Yin; Shu-Tao Xie; Hong-Zhao Li; Chao Yan; Jian-Jun Wang; Qipeng Zhang; Xiao-Yang Zhang; Jing-Ning Zhu (The Cerebellum, 2022)

Fine-mapping and association analysis of candidate genes for papilla number in sea cucumber, Apostichopus japonicus - Xinghai Zhu; Ping Ni; Marc Sturrock; Yangfan Wang; Jun Ding; Yaqing Chang; Jingjie Hu; Zhenmin Bao (Marine Life Science & Technology, 2022)
The papilla number is one of the most economically important traits of sea cucumber in the China marketing trade. However, the genetic basis for papilla number diversity in holothurians is still scarce. In the present study, we conducted genome-wide association studies (GWAS) for the trait papilla number of sea cucumbers utilizing a set of 400,186 high-quality SNPs derived from 200 sea cucumbers. Two significant trait-associated SNPs that passed Bonferroni correction ( P < 1.25E−7) were located in the intergenic region near PATS1 and the genic region of EIF4G , which were reported to play a pivotal role in cell growth and proliferation. The fine-mapping regions around the top two lead SNPs provided precise causative loci/genes related to papilla formation and cellular activity, including PPP2R3C , GBP1 , and BCAS3 . Potential SNPs with P < 1E−4 were acquired for the following GO and KEGG enrichment analysis. Moreover, the two lead SNPs were verified in another population of sea cucumber, and the expressive detection of three potential candidate genes PATS1 , PPP2R3C , and EIF4G that near or cover the two lead SNPs was conducted in papilla tissue of TG (Top papilla number group) and BG (Bottom papilla number group) by qRT-PCR. We found the significantly higher expression profile of PATS1 (3.34-fold), PPP2R3C (4.90-fold), and EIF4G (4.23-fold) in TG, implying their potential function in papilla polymorphism. The present results provide valuable information to decipher the phenotype differences of the papilla trait and will provide a scientific basis for selective breeding in sea cucumbers.

Two new terpenes from the aerial parts of Clematis chinensis Osbeck - Sun Ye; Liu Yan; Yan-Ping Sun; Xiao-Mao Li; Wang Si-Yi; Juan Pan; Wei Guan; Yuan Liu; Anam Naseem; Bing-You Yang; Hai-Xue Kuang (Natural Product Research, 2022)

Comprehensive Transcriptome Analysis of Tea Crabapple (Malus hupehensis Rehd.) Roots Subjected to Mixed Saline–Alkali Stress - Xin-Liang Wang; Ling Peng; Jian Wang; Jing-Jing Jia; Li-Ping Tang (Plant Molecular Biology Reporter, 2022)

Recent advances in metabolic regulation and bioengineering of gibberellic acid biosynthesis in Fusarium fujikuroi - Hao-Nan Wang; Xia Ke; Jun-Ping Zhou; Zhi-Qiang Liu; Yu-Guo Zheng (World Journal of Microbiology and Biotechnology, 2022)

Comparative chloroplast genomes and phylogenetic analyses of Pinellia - Ning Cui; Weixu Chen; Xiwen Li; Ping Wang (Molecular Biology Reports, 2022)
Background Pinellia Tenore (Araceae) is a genus of perennial herbaceous plants, all of which have medicinal value. The chloroplast (cp) genome data of Pinellia are scarce, and the phylogenetic relationship and gene evolution remain unclear. Methods and results We sequenced and annotated the Pinellia pedatisecta cp genome and combined it with previously published genomes for other Pinellia species. We used bioinformatics methods to analyse the genomic structure, repetitive sequences, interspecific variation, divergence hotspots, phylogenetic relationships, divergence time estimation and selective pressure of four Pinellia plastomes. Results showed that the cp genomes of Pinellia varied in length between 168,178 ( P. pedatisecta MN046890) and 164,013 bp ( P. ternata KR270823). A total of 68–111 SSR loci were identified as candidate molecular markers for further genetic diversity study. Eight mutational hotspot regions were determined, including psbI-trnG-UCC, psbM-rpoB, ndhJ-trnT-UGU, trnP-UGG-trnW-CCA, ndhF-trnN-GUU, ndhG-ndhE, ycf1-rps15 and trnR-ycf1 . Gene selection pressure suggested that four genes were subjected to positive selection. Phylogenetic inferences based on the complete cp genomes revealed a sister relationship between Pinellia and Arisaema plants whose divergence was estimated to occur around 22.48 million years ago. All Pinellia species formed a monophyletic evolutionary clade in which P. peltata , rather than P. pedatisecta , earlier diverged, indicating that P. pedatisecta is not the basal taxon of Pinellia but P. peltata may be. Conclusions The cp genomes of Pinellia will provide valuable information for species classification, identification, molecular breeding and evolutionary exploration of the genus Pinellia .

The initial impoundment of the Baihetan reservoir region (China) exacerbated the deformation of the Wangjiashan landslide: characteristics and mechanism - Xiaoyu Yi; Wenkai Feng; Mingtang Wu; Zhiping Ye; Yunfeng Fang; Ping Wang; Renjiang Li; Jiawei Dun (Landslides, 2022)

Transport process and mechanism of the Hongshiyan rock avalanche triggered by the 2014 Ludian earthquake, China - Shi-lin Zhang; Yue-ping Yin; Hai-bo Li; Wen-pei Wang; Jia-wen Zhou (Landslides, 2022)

Recombinant jurkat cells (HMGN2-T cells) secrete cytokines and inhibit the growth of tumor cells - Huanhuan Li; Xueqiang Wu; Dingfang Bu; Lihua Wang; Xueju Xu; Yingchao Wang; Yufeng Liu; Ping Zhu (Journal of Molecular Histology, 2022)

The Effects of Diameter, Length and Insertion Method on the Stability of Orthodontic Miniscrew - Wan-Ping Yu; Jian-Hong Yu; Shiuan-Hui Wang; Jui-Ting Hsu (Journal of Medical and Biological Engineering, 2022)

Trochanteric Nails for the Reduction of Intertrochanteric Fractures: A Biomechanical Analysis Based on Finite Element Analysis and DIC System - Ming-Tzu Tsai; Cheng-Hung Lee; Kun-Hui Chen; Yu-Chun Yen; Chun-Hsiang Wang; Shun-Ping Wang; Kuo-Chih Su (Journal of Medical and Biological Engineering, 2022)
Purpose Intertrochanteric fractures are common among femoral fractures in the elderly population. The trochanteric nail is a standard internal fixator used in treating femoral intertrochanteric fractures. The technique of femoral fracture reduction affects the postoperative outcome. Here, we applied finite element analysis (FEA) to study mechanical effects of different reduction approaches using the trochanteric nail in treating both stable and unstable intertrochanteric fractures. Methods We combined FEA and in vitro experiments using a digital imaging correlation (DIC) technique to study effects of different alignment conditions after treating 4 cases of intertrochanteric fractures using the trochanteric nail system. A downward force of 2250 N was applied to the femoral head, and the distal end of the femur was fixed. The observed indicators were the femur displacement, together with the stress on the femur and trochanteric nail system. In addition, the displacement distribution was analyzed using DIC. Results In the case of space reduction, the force was transmitted by the trochanteric nail system, resulting in greater stress imposed on the femur or the trochanteric nail system. In the case of closed reduction, the stress was much smaller. In the case of unstable fracture reduction, closed reduction was associated with a smaller contact area at the fracture site, resulting in greater stress on both trochanter and the trochanteric nail system. Conclusion When the trochanteric nail system was used for fixation, the fracture site was well aligned, reducing the stress on the femur or the trochanteric nail.

On the Mechanism of Stress Superposition Inducing Outburst Under the Influence of Blind Fault Instability - Xun Zhao; Tao Feng; Ping Wang; Pengfei Wang; Ze Liao; Hongsheng Li; Ze Zhou (Geotechnical and Geological Engineering, 2022)

Microfluidic preparation of a novel phoxim nanoemulsion pesticide against Spodoptera litura - Zong-Nan Li; Yu-Xuan Zhang; Zhi-Ang Zhang; Lian-Han Pan; Ping Li; Yan Xu; Sheng Sheng; Fu-An Wu; Jun Wang (Environmental Science and Pollution Research, 2022)

Hydrogen sulfide supplement preserves mitochondrial function of retinal ganglion cell in a rat glaucoma model - Shouyue Huang; Ping Huang; Huan Yu; Junjue Chen; Xiaohong Liu; Jing Wang; Xi Shen; Yisheng Zhong (Cell and Tissue Research, 2022)

Ginseng volatile oil prolongs the lifespan and healthspan of Caenorhabditis elegans - Lixin Wang; Ping Qiao; Zhuoer Ouyang; Danyang Li; Jingtong Zheng; Guoqiang Wang; Fang Wang (Biogerontology, 2022)

LncRNA LOXL1-AS1 Facilitates the Oncogenic Character in Cervical Cancer by the miR-526b-5p /LYPLA1 Axis - Yanhua Zhang; Meng Zheng; Lingyan Zhang; Ping Yuan; Jianbo Zhou; Yongfang Wang; Haihong Wang (Biochemical Genetics, 2022)

The effects of dietary fermented wheat bran polysaccharides on mucosal and serum immune parameters, hepatopancreas antioxidant indicators, and immune-related gene expression of common carp (Cyprinus carpio) juveniles - Rui-Fang Wang; Yuan Wang; Jun Zhang; Mei-Qi Weng; Yu-Hui Liu; Qiu-Yan Cheng; Min Song; Yan-Ping Yang; Xiao-Ping An; Jing-Wei Qi (Aquaculture International, 2022)

Deepened snow loosens temporal coupling between plant and microbial N utilization and induces ecosystem N losses - Zhou Jia; Ping Li; Yuntao Wu; Pengfei Chang; Meifeng Deng; Luyin Liang; Sen Yang; Chengzhang Wang; Bin Wang; Lu Yang; Xin Wang; Zhenhua Wang; et al. (Global Change Biology, 2022)
Seasonal differences in plant and microbial nitrogen (N) acquisition are believed to be a major mechanism that maximizes ecosystem N retention. There is also a concern that climate change may interrupt the delicate balance in N allocation between plants and microbes. Yet, convincing experimental evidence is still lacking. Using a 15 N tracer, we assessed how deepened snow affects the temporal coupling between plant and microbial N utilization in a temperate Mongolian grassland. We found that microbial 15 N recovery peaked in winter, accounting for 22% of the total ecosystem 15 N recovery, and then rapidly declined during the spring thaw. By stimulating N loss via N 2 O emission and leaching, deepened snow reduced the total ecosystem 15 N recovery by 42% during the spring thaw. As the growing season progresses, the 15 N released from microbial biomass was taken up by plants, and the competitive advantage for N shifted from microbes to plants. Plant 15 N recovery reached its peak in August, accounting for 17% of the total ecosystem 15 N recovery. The Granger causality test showed that the temporal dynamics of plant 15 N recovery can be predicted by microbial 15 N recovery under ambient snow but not under deepened snow. In addition, plant 15 N recovery in August was positively correlated with and best explained by microbial 15 N recovery in March. The lower microbial 15 N recovery under deepened snow in March reduced plant 15 N recovery by 73% in August. Together, our results provide direct evidence of seasonal differences in plant and microbial N utilization that are conducive to ecosystem N retention; however, deepened snow disrupted the temporal coupling between plant–microbial N use and turnover. These findings suggest that changes in snowfall patterns may significantly alter ecosystem N cycling and N‐based greenhouse gas emissions under future climate change. We highlight the importance of better representing winter processes and their response to winter climate change in biogeochemical models when assessing N cycling under global change.

Male Predisposition in Cerebellar Mutism Syndrome: a Cohort Study - Wei Yang; Ming Ge; Kaiyi Zhu; Jiashu Chen; Ping Yang; Yingjie Cai; XiaoJiao Peng; Jia Wang; Hailang Sun; Yuanqi Ji; Fengmao Zhao; Hong Zhang (The Cerebellum, 2022)

Hyperparameter Optimization for the LSTM Method of AUV Model Identification Based on Q-Learning - Dianrui Wang; Junhe Wan; Yue Shen; Ping Qin; Bo He (Journal of Marine Science and Engineering, 2022)
An accurate mathematical model is a basis for controlling and estimating the state of an Autonomous underwater vehicle (AUV) system, so how to improve its accuracy is a fundamental problem in the field of automatic control. However, AUV systems are complex, uncertain, and highly non-linear, and it is not easy to obtain through traditional modeling methods. We fit an accurate dynamic AUV model in this study using the long short-term memory (LSTM) neural network approach. As hyper-parameter values have a significant impact on LSTM performance, it is important to select the optimal combination of hyper-parameters. The present research uses the improved Q-learning reinforcement learning algorithm to achieve this aim by improving its recognition accuracy on the verification dataset. To improve the efficiency of action exploration, we improve the Q-learning algorithm and choose the optimal initial state according to the Q table in each round of learning. It can effectively avoid the ineffective exploration of the reinforcement learning agent between the poor-performing hyperparameter combinations. Finally, the experiments based on simulated or actual trial data demonstrate that the proposed model identification method can effectively predict kinematic motion data, and more importantly, the modified Q-Learning approach can optimize the network hyperparameters in the LSTM.

A review on chemical and physical modifications of phytosterols and their influence on bioavailability and safety - Simin Feng; Liling Wang; Ping Shao; Peilong Sun; Chung S. Yang (Critical Reviews in Food Science and Nutrition, 2022)

Shanzhiside methylester protects against depression by inhibiting inflammation via the miRNA-155-5p/SOCS1 axis - Zhongwen Sun; Honggang Zhan; Cheng Wang; Ping Guo (Psychopharmacology, 2022)

Correction to: Exercise Rehabilitation and/or Astragaloside Attenuate Amyloid-beta Pathology by Reversing BDNF/TrkB Signaling Deficits and Mitochondrial Dysfunction - Yu-Lin Wang; Chung-Ching Chio; Shu-Chun Kuo; Chao-Hung Yeh; Jui-Ti Ma; Wen-Pin Liu; Mao-Tsun Lin; Kao-Chang Lin; Ching-Ping Chang (Molecular Neurobiology, 2022)

Design and synthesis of ludartin derivatives as potential anticancer agents against hepatocellular carcinoma - Jin-Jin Sun; Jin-Ping Wang; Tian-Ze Li; Yun-Bao Ma; Dong Xue; Ji-Jun Chen (Medicinal Chemistry Research, 2022)

Erratum to: Temporal changes in wetland plant communities with decades of cumulative water pollution in two plateau lakes in China’s Yunnan Province - Si-hai Wang; Chao Wu; De-rong Xiao; Juan Wang; Xi-ping Cheng; Fang-bin Guo (Journal of Mountain Science, 2022)

Antioxidant, Transcriptomic and Metabonomic Analysis of Hepatopancreatic Stress Resistance in Exopalaemon carinicauda Following Astaxanthin Feeding - Wenyang Li; Jiajia Wang; Jitao Li; Ping Liu; Jian Li; Fazhen Zhao (Frontiers in Marine Science, 2022)
Astaxanthin (Axn) is a xanthophyll carotenoid that has previously been shown to suppress hepatic inflammation, reduce oxidative liver damage, and improve metabolic profiles. Exopalaemon carinicauda ( E. carinicauda ) is an economically important fishery species in China that has been found to exhibit increased body weight following Axn feeding as compared to a standard diet. In this study, dietary Axn can significantly decreased MDA content, T-AOC and significantly increased SOD, GSH and CAT activities in shrimp hepatopancreas. Moreover, transcriptome and metabolome of E. carinicauda after Axn feeding were investigated to identify the mechanism of the effect of Axn on E. carinicauda . The transcriptomic data revealed that a total 99 different expression genes (DEGs) were identified between the Axn and control groups, of which 47 and 52 were upregulated and downregulated, respectively. DEGs of E. carinicauda such as catherpsin, actin and PARP after Axn feeding were associated with apoptosis and immune system. The metabolomic analysis revealed that A total of 73 different expression metabolites (DEMs) were identified in both metabolites, including 30 downregulated metabolites and 43 upregulated metabolites. And Axn participate in metabolism processes in hepatopancreas of E. carinicauda , including the TCA cycle, amino acid metabolism and lipid metabolism. The multiple comparative analysis implicated that Axn can improve the antioxidant capacity of hepatopancreas and the energy supply of hepatopancreas mitochondria, and then improve the ability of anti-apoptosis. Collectively, all these results will greatly provide new insights into the molecular mechanisms underlying tolerance of adverse environment in E. carinicauda .

Sandstorms cause shrinkage of Haloxylon ammodendron shrubs and limit their self-renewal - Sheng-bo Shi; Dang-wei Zhou; Fang-lin Wang; Rui Shi; Tao Sun; Tian-cai Li; Jia-lin Ma; Xiang Wan; Jian-ping Ma; Jing-nian Tang (Theoretical and Experimental Plant Physiology, 2022)
Haloxylon ammodendron is an excellent windproof and sand-fixing species whose shrubs are widely cultivated in arid desert areas of northwest China but are now at risk of degradation and shrinkage. Using the chlorophyll fluorescence image analysis technique, the response of photosystem II (PSII) photochemical efficiency and non-photochemical quenching capacity to sediment-carrying wind and sand-free wind (both 12 m s −1 ) lasting for 10, 20, and 40 min were studied with seedlings in a wind tunnel. The results indicated that the sand-free wind had little influence on the maximum quantum efficiency of PSII photochemistry, F v / F m , which was approximately 0.80 on average; however, the F v / F m decreased over exposure time in the sediment-carrying wind group, with values smaller than those in the wind-only group. The non-photochemical quenching was sensitive to wind erosion, and sediment-carrying wind could aggravate the reduction in non-photochemical quenching ( NPQ ). Except for the 10 min duration, the maximum quantum efficiency of PSII photochemistry after dark recovery for 15 min, F v r / F m r , was lower in seedlings exposed to sediment-carrying wind than in those in the wind-only group. Compared to wind-only, wind-blown sand led to a water imbalance and withering in seedlings, causing the concentration of photosynthetic pigments (when based on the fresh mass of green branches) to not decrease. With a longer exposure time to sediment-carrying wind, both the probability and extent of lignified spots occurring increased in green assimilative branches. Our results demonstrated that sediment-carrying wind at 12 m s −1 lasting for 20 min or more could cause irreversible damage to the photosynthetic apparatus of H. ammodendron seedlings. Therefore, frequent and strong sandstorms are the main disturbance factors leading to shrinkage of shrubs and limiting their self-renewal.

CD146 as a promising therapeutic target for retinal and choroidal neovascularization diseases - Bai Xue; Ping Wang; Wenzhen Yu; Jing Feng; Jie Li; Rulian Zhao; Zhenglin Yang; Xiyun Yan; Hongxia Duan (Science China Life Sciences, 2022)

Field Study of Compaction Quality Control Parameters and Compaction Mechanism of Large Particle Size Stone-filled Embankment - Ping Xu; Xiong Zhu; Shifan Qiao; Gang Wang; Pengkun Yu (Rock Mechanics and Rock Engineering, 2022)

High-Density Lipoprotein Is Associated with Leukoaraiosis Severity in Patients with Acute Ischemic Stroke - Ping Wang; Zhaoxia Liu; Xuan Liu; Jing Sun; Zhiyuan Qian; Xingshun Xu (Neurotoxicity Research, 2022)

Research on Ecological Security of Shengjin Lake Wetland (Anhui Province of China) Based on TM Images - Zhili Xu; Bin Dong; Xiang Gao; Ping Wang; Qing Wang; Sheng Li; Haifeng Xu; Yaru Liu; Tong Wang; Chunqiu Ren (Journal of the Indian Society of Remote Sensing, 2022)

Salicylic Acid Induces Vanadium Stress Tolerance in Rice by Regulating the AsA-GSH Cycle and Glyoxalase System - Muhammad Mohsin Altaf; Xiao-ping Diao; Haihua Wang; Latif Ullah Khan; Atique ur Rehman; Awais Shakoor; Muhammad Ahsan Altaf; Taimoor Hassan Farooq (Journal of Soil Science and Plant Nutrition, 2022)

Should Plate-Bone Gap be Preserved in Far-Cortical Locking Technique? A Biomechanical Study - Shun-Ping Wang; Yang-Chen Chou; Cheng-En Hsu; Chi-Wen Chou; Chao-Ping Chen; Kun-Jhih Lin; Fuu-Cheng Jiang; Wen-Chuan Chen; Chen-Chiang Lin (Journal of Medical and Biological Engineering, 2022)

Breast Cancer Awareness Based on Health Information Literacy and Influential Factors among Female Nursing Students in China - Shu Yang; Ping Li; Lin Yu; Na Liu; Jie Wang; Pingping Guo; Xuehui Zhang; Wei Zhang (Journal of Cancer Education, 2022)

A20 attenuates pyroptosis and apoptosis in nucleus pulposus cells via promoting mitophagy and stabilizing mitochondrial dynamics - Xin Peng; Cong Zhang; Zhi-Min Zhou; Kun Wang; Jia-Wei Gao; Zhan-Yang Qian; Jun-Ping Bao; Hang-Yu Ji; V. L. F. Cabral; Xiao-Tao Wu (Inflammation Research, 2022)

Genome wide association analysis of acid detergent fiber content of 206 forage sorghum (Sorghum bicolor (L.) Moench) accessions - Hao Niu; Yuanhuai Han; Junai Ping; Yubin Wang; Xin Lv; Jianqiang Chu (Genetic Resources and Crop Evolution, 2022)

Use of DNA nanosensors based on upconverting nanoparticles for detection of Nosema bombycis by fluorescence resonance energy transfer - Ping He; Hongli Chen; Jiancheng Sun; Qiang Wang; Xudong Tang; Yiling Zhang; Feng Zhu; Zhongyuan Shen (Folia Microbiologica, 2022)

Different interventions for preventing postoperative catheter-related bladder discomfort: a systematic review and meta-analysis - Shuying Li; Ping Li; Rurong Wang; Hui Li (European Journal of Clinical Pharmacology, 2022)

Enrichment and occurrence form of rare earth elements during coal and coal gangue combustion - Guoqiang Wu; Nan Shi; Tao Wang; Chin-Min Cheng; Jiawei Wang; Chunxiao Tian; Wei-Ping Pan (Environmental Science and Pollution Research, 2022)

Rapid triage for ischemic stroke: a machine learning-driven approach in the context of predictive, preventive and personalised medicine - Yulu Zheng; Zheng Guo; Yanbo Zhang; Jianjing Shang; Leilei Yu; Ping Fu; Yizhi Liu; Xingang Li; Hao Wang; Ling Ren; Wei Zhang; Haifeng Hou; et al. (EPMA Journal, 2022)
Background Recognising the early signs of ischemic stroke (IS) in emergency settings has been challenging. Machine learning (ML), a robust tool for predictive, preventive and personalised medicine (PPPM/3PM), presents a possible solution for this issue and produces accurate predictions for real-time data processing. Methods This investigation evaluated 4999 IS patients among a total of 10,476 adults included in the initial dataset, and 1076 IS subjects among 3935 participants in the external validation dataset. Six ML-based models for the prediction of IS were trained on the initial dataset of 10,476 participants (split participants into a training set [80%] and an internal validation set [20%]). Selected clinical laboratory features routinely assessed at admission were used to inform the models. Model performance was mainly evaluated by the area under the receiver operating characteristic (AUC) curve. Additional techniques—permutation feature importance (PFI), local interpretable model-agnostic explanations (LIME), and SHapley Additive exPlanations (SHAP)—were applied for explaining the black-box ML models. Results Fifteen routine haematological and biochemical features were selected to establish ML-based models for the prediction of IS. The XGBoost-based model achieved the highest predictive performance, reaching AUCs of 0.91 (0.90–0.92) and 0.92 (0.91–0.93) in the internal and external datasets respectively. PFI globally revealed that demographic feature age, routine haematological parameters, haemoglobin and neutrophil count, and biochemical analytes total protein and high-density lipoprotein cholesterol were more influential on the model’s prediction. LIME and SHAP showed similar local feature attribution explanations. Conclusion In the context of PPPM/3PM, we used the selected predictors obtained from the results of common blood tests to develop and validate ML-based models for the diagnosis of IS. The XGBoost-based model offers the most accurate prediction. By incorporating the individualised patient profile, this prediction tool is simple and quick to administer. This is promising to support subjective decision making in resource-limited settings or primary care, thereby shortening the time window for the treatment, and improving outcomes after IS.

The Joint Toxicity of Organic Three-dimensional Layered Double Hydroxide and Methyl Orange to Green Algae Chlorella Vulgaris - Fangfang Qiu; Yuxuan Xie; Qinyuan Wang; Xuemei Pan; Mingxue Xiang; Ping Zhang (Bulletin of Environmental Contamination and Toxicology, 2022)

Investigation on long-term progressive deformation of engineering slope based on comprehensive monitoring - Shi-shu Zhang; Song-feng Guo; Sheng-wen Qi; Feng-jiao Tang; Jin-shan Hu; Xiao-ping Zhao; Cong-yan Ran; Xin Wang; Yu Zou; Xiao-lin Huang; Bo-wen Zheng; Ning Liang (Journal of Mountain Science, 2022)

Abundance, Diversity and Functional Potentials of Planktonic Bacteria and Microeukaryotes in the Coral-Reef System of Xisha Islands, China - Xiaoli Zhang; Lei Wang; Saijun Peng; Qiyue Wuzhong; Lei Zhang; Zhijun Dong; Tingting Sun; Ping Liu; Qianqian Zhang; Jianmin Zhao (Journal of Ocean University of China, 2022)

Adventitious bud regeneration and Agrobacterium tumefaciens-mediated genetic transformation of Eucalyptus urophylla × E. tereticornis interspecific hybrid - Xiaoping Wang; Ping Luo; Zhenfei Qiu; Xiaodan Li; Bingshan Zeng; Chunjie Fan (In Vitro Cellular & Developmental Biology - Plant, 2022)

Molecular characterization of a novel alternavirus infecting the entomopathogenic fungus Cordyceps chanhua - Yuxiang Zhang; Najie Shi; Ping Wang; Qiuyan Zhu; Guogen Yang; Bo Huang (Archives of Virology, 2022)

Evaluation of genetic variants in nucleosome remodeling and deacetylase (NuRD) complex subunits encoding genes and gastric cancer susceptibility - Yujuan Zhang; Guoquan Tao; Ping Liu; Kai Lu; Zhichao Han; Hanting Liu; Mulong Du; Meilin Wang; Haiyan Chu; Zhengdong Zhang (Archives of Toxicology, 2022)

Wavefield reconstruction inversion with weak-total-variation constraint based on first arrival traveltime tomography - Shao-Shun Zhang; Jian-Ping Huang; Zhen-Yu Wang (Applied Geophysics, 2022)

Expanding the clinical spectrum of adult-onset neuronal intranuclear inclusion disease - Yuwen Cao; Jingying Wu; Yunhua Yue; Chao Zhang; Shihua Liu; Ping Zhong; Shige Wang; Xiaojun Huang; Weiping Deng; Jing Pan; Lan Zheng; Qing Liu; et al. (Acta Neurologica Belgica, 2022)

Bridge to the future: Important lessons from 20 years of ecosystem observations made by the OzFlux network - Jason Beringer; Caitlin E. Moore; Jamie Cleverly; David I. Campbell; Helen Cleugh; Martin G. De Kauwe; Miko U. F. Kirschbaum; Anne Griebel; Sam Grover; Alfredo Huete; Lindsay B. Hutley; Johannes Laubach; et al. (Global Change Biology, 2022)
In 2020, the Australian and New Zealand flux research and monitoring network, OzFlux, celebrated its 20 th anniversary by reflecting on the lessons learned through two decades of ecosystem studies on global change biology. OzFlux is a network not only for ecosystem researchers, but also for those ‘next users’ of the knowledge, information and data that such networks provide. Here, we focus on eight lessons across topics of climate change and variability, disturbance and resilience, drought and heat stress and synergies with remote sensing and modelling. In distilling the key lessons learned, we also identify where further research is needed to fill knowledge gaps and improve the utility and relevance of the outputs from OzFlux. Extreme climate variability across Australia and New Zealand (droughts and flooding rains) provides a natural laboratory for a global understanding of ecosystems in this time of accelerating climate change. As evidence of worsening global fire risk emerges, the natural ability of these ecosystems to recover from disturbances, such as fire and cyclones, provides lessons on adaptation and resilience to disturbance. Drought and heatwaves are common occurrences across large parts of the region and can tip an ecosystem's carbon budget from a net CO 2 sink to a net CO 2 source. Despite such responses to stress, ecosystems at OzFlux sites show their resilience to climate variability by rapidly pivoting back to a strong carbon sink upon the return of favourable conditions. Located in under‐represented areas, OzFlux data have the potential for reducing uncertainties in global remote sensing products, and these data provide several opportunities to develop new theories and improve our ecosystem models. The accumulated impacts of these lessons over the last 20 years highlights the value of long‐term flux observations for natural and managed systems. A future vision for OzFlux includes ongoing and newly developed synergies with ecophysiologists, ecologists, geologists, remote sensors and modellers.

Mycorrhizal fungi alleviate acidification‐induced phosphorus limitation: Evidence from a decade‐long field experiment of simulated acid deposition in a tropical forest in south China - Yuanliu Hu; Ji Chen; Dafeng Hui; Ying‐Ping Wang; Jianling Li; Jingwen Chen; Guoyin Chen; Yiren Zhu; Leiyi Zhang; Deqiang Zhang; Qi Deng (Global Change Biology, 2022)
South China has been experiencing very high rate of acid deposition and severe soil acidification in recent decades, which has been proposed to exacerbate the regional ecosystem phosphorus (P) limitation. We conducted a 10‐year field experiment of simulated acid deposition to examine how acidification impacts seasonal changes of different soil P fractions in a tropical forest with highly acidic soils in south China. As expected, acid addition significantly increased occluded P pool but reduced the other more labile P pools in the dry season. In the wet season, however, acid addition did not change microbial P, soluble P and labile organic P pools. Acid addition significantly increased exchangeable Al 3+ and Fe 3+ and the activation of Fe oxides in both seasons. Different from the decline of microbial abundance in the dry season, acid addition increased ectomycorrhizal fungi and its ratio to arbuscular mycorrhiza fungi in the wet season, which significantly stimulated phosphomonoesterase activities and likely promoted the dissolution of occluded P. Our results suggest that, even in already highly acidic soils, the acidification‐induced P limitation could be alleviated by stimulating ectomycorrhizal fungi and phosphomonoesterase activities. The differential responses and microbial controls of seasonal soil P transformation revealed here should be implemented into ecosystem biogeochemical model for predicting plant productivity under future acid deposition scenarios.

Episodic Neoproterozoic extension-related magmatism in the Altyn Tagh, NW China: implications for extension and breakup processes of Rodinia supercontinent - Jiang-bo Hao; Chao Wang; Ji-heng Zhang; Liang Liu; Yong-sheng Gai; Hang Li; Zun-pu Yu; Joseph G Meert; Xiao-ping Long; Xiao-kui Sun; Shuai Zhang (International Geology Review, 2022)

Medium chain triglyceride and medium-and long chain triglyceride: metabolism, production, health impacts and its applications – a review - Yee-Ying Lee; Teck-Kim Tang; Eng-Seng Chan; Eng-Tong Phuah; Oi-Ming Lai; Chin-Ping Tan; Yong Wang; Nur Azwani Ab Karim; Noorlida Habi Mat Dian; Joo Shun Tan (Critical Reviews in Food Science and Nutrition, 2022)

Changes in Organic Carbon Delivery to the Yangtze River Delta Over the Last 2000 Years - Liang Zhou; Yang Yang; Yong Shi; Xiaomei Xu; Ya Ping Wang; Jianjun Jia; Jian Hua Gao; Shu Gao (Frontiers in Marine Science, 2022)
Natural processes and anthropogenic activities are vital in dictating the amount and character of organic carbon (OC) input into large river deltas and adjacent shelves. Previous studies have indicated that sediment from the Huanghe River (HR) has significantly affected the formation of the northern Yangtze River subaqueous delta (YRD) over the past several hundred years. However, whether this process has changed sedimentary OC burial in the YRD remains unclear. A sediment core was collected from the YRD in 2018 CE for optically stimulated luminescence and 210 Pb dating as well as grain size, total OC, total nitrogen, and stable-isotope analyses to investigate temporal changes in sedimentary OC over the past 2000 years. The results indicate that changes in terrestrial OC inputs to the YRD have been controlled mainly by the East Asian summer monsoon and anthropogenic influences in the past 2000 years. However, the decreased terrestrial OC inputs after 1385 CE, have been significantly affected by increased contribution of HR sediment to the YRD when the HR lower courses shifted to enter the southern Yellow Sea. This study demonstrates that sediment source changes should not be neglected in analyses of mechanisms and variations in OC burial in estuarine and coastal areas.

Dynamic Cause of the Sudden Death Event of Small Yellow Croaker (Larimichthys polyactis) in the East China Sea in Winter 2017 - Zilu Wei; Xiaohui Jiao; Jicai Zhang; Yunfei Du; Zengrui Rong; Hui Wu; Ya Ping Wang (Frontiers in Marine Science, 2022)
Small yellow croaker ( Larimichthys polyactis ), a benthic fish species widely distributed in the Northwest Pacific Ocean, plays an important role in the fishery catch of coastal countries. A large amount of dead small yellow croaker floated on the sea surface near 30.2°N, 125.3°E in the East China Sea on 19 February 2017, and more than 9,000 kilograms were caught by fishermen, which had never been recorded before. This study aims to investigate the dynamic causes of this sudden death event based on available in-situ, satellite and modelling data. The event occurred near the overwintering ground of small yellow croaker, where a majority of these fish assembled in winter. There were persistent ocean fronts at target site with average intensity of 0.05°C/km at sea surface and bottom in February 2017, which was the strongest in the past 5 years from 2015 to 2019. The fronts provided nutrients and food to fish, and the intense gradients prevented fish from crossing, thus forming “water barriers” to restrict the horizontal movement of fish. Due to enhanced convection, the water was well-mixed, enabling the demersal croaker to float to sea surface. The sea temperature was particularly warm in winter 2017, but then experienced a significant drop by more than 4.5°C in 40 days according to satellite and modelling datasets due to the northerly wind and the southeastward movement of cold eddy. The drop of temperature led to ‘cold shock’ of fish, affecting their physiological regulation and survival. Under the combined influence of these factors, a large number of small yellow croaker died and aggregated near the target site. This paper has a great reference value for further study on the living habits of small yellow croaker and their responses to marine dynamic changes.

Citrus flavonoids and their antioxidant evaluation - Yue Wang; Xiao-Juan Liu; Jie-Biao Chen; Jin-Ping Cao; Xian Li; Chong-De Sun (Critical Reviews in Food Science and Nutrition, 2022)

Complete genome sequence of a novel chlorobenzene degrader, Burkholderia stabilis TF-2 - Xiao-Ping Zhang; Yan-Hui Gao; Zhi-Lin Xing; Yong-Qiong Wang; Tian-Tao Zhao (Biologia, 2022)

Determination of fluoroquinolones in chicken muscle by molecularly imprinted graphitic carbon nitride-based solid-phase extraction and ultra-performance liquid chromatography - Su Han Wang; Ning Ma; Xiao Huan Zang; Shuai Hua Zhang; Jian Ping Wang; Ning Peng Wu (Food Additives & Contaminants: Part A, 2022)

One new piperazinedione isolated from a mangrove-derived fungus Aspergillus niger JX-5 - Meng Bai; Yue Wang; Ting Liu; Yu-Xing Lian; Qi-Qi Bai; Xiao-Ping Song; Chang-Ri Han; Cai-Juan Zheng; Guang-Ying Chen (Natural Product Research, 2022)

Expert consensus on organizing the multidisciplinary team (MDT) diagnosis and treatment of hepato-pancreato-biliary diseases in China - Binhao Zhang; Jian Zhou; Weifen Xie; Kaishan Tao; Shichun Lu; Xianglin Yuan; Lianxin Liu; Weilin Wang; Yilei Mao; Ping Bie; Jingfeng Liu; Xinyu Bi; et al. (Science China Life Sciences, 2022)

Ultrasound-induced biophysical effects in controlled drug delivery - Lulu Zhang; Zhuohua Lin; Lan Zeng; Fan Zhang; Lihong Sun; Suhui Sun; Ping Wang; Menghong Xu; Jinxia Zhang; Xiaolong Liang; Huiyu Ge (Science China Life Sciences, 2022)

Mutation of Beclin1 acetylation site at K414 alleviates high glucose-induced podocyte impairment in the early stage of diabetic nephropathy by inhibiting hyperactivated autophagy - Jun Xu; Yujie Deng; Yingying Ke; Yunxia Zhu; Ping Wang; Qing Yu; Chengqian Li; Bimin Shi (Molecular Biology Reports, 2022)

PrPSc Inhibition and Cellular Protection of DBL on a Prion-Infected Cultured Cell via Multiple Pathways - Wei Yang; Cao Chen; Jia Chen; Ying Xia; Chao Hu; Lin Wang; Yue-Zhang Wu; Qi Shi; Zhi-Bao Chen; Xiao-Ping Dong (Molecular Neurobiology, 2022)

Effects of Involuntary and Voluntary Exercise in Combination with Acousto-Optic Stimulation on Adult Neurogenesis in an Alzheimer's Mouse Model - Wan-yi Li; Jun-yan Gao; Su-Yang Lin; Shao-tao Pan; Biao Xiao; Yu-tao Ma; Kai Xie; Wei Shen; Zhi-tao Liu; Guang-yu Li; Jie-jie Guo; Qin-wen Wang; et al. (Molecular Neurobiology, 2022)

Exercise Rehabilitation and/or Astragaloside Attenuate Amyloid-beta Pathology by Reversing BDNF/TrkB Signaling Deficits and Mitochondrial Dysfunction - Yu-Lin Wang; Chung-Ching Chio; Shu-Chun Kuo; Chao-Hung Yeh; Jui-Ti Ma; Wen-Pin Liu; Mao-Tsun Lin; Kao-Chang Lin; Ching-Ping Chang (Molecular Neurobiology, 2022)

First report of Capsicum frutescens endornavirus 1 infecting pepper in China - Ming-xia Gong; Hu Zhao; Xing Wu; Meng Wang; Zeng-jing Zhao; Zhi He; Ru-kui Huang; Jing-ping Sun; Ri-sheng Wang (Journal of Plant Pathology, 2022)

MiR-1260b protects against LPS-induced degenerative changes in nucleus pulposus cells through targeting TCF7L2 - Shijie Chen; Guixia Shi; Jin Zeng; Ping Huang Li; Yi Peng; Zhiyu Ding; Hong Qing Cao; Ruping Zheng; Weiguo Wang (Human Cell, 2022)

Dissociable causal roles of the frontal and parietal cortices in the effect of object location on object identity detection: a TMS study - Ping Yang; Min Wang; Cimei Luo; Xuejin Ni; Ling Li (Experimental Brain Research, 2022)

Response of net ecosystem CO2 exchange to precipitation events in the Badain Jaran Desert - Ping Yang; Liqiang Zhao; Xueran Liang; Zhenmin Niu; Hang Zhao; Yuanyuan Wang; Nai’ang Wang (Environmental Science and Pollution Research, 2022)

Analysis on ecological status and spatial–temporal variation of Tamarix chinensis forest based on spectral characteristics and remote sensing vegetation indices - Jin Wang; Ping Han; Yanhua Zhang; Jinyu Li; Linxu Xu; Xue Shen; Zhigang Yang; Sisi Xu; Guangxue Li; Feiyong Chen (Environmental Science and Pollution Research, 2022)

Study on pressure arch effect of xigeda strata tunnel based on experiment and discrete element simulation - Ping Zhou; Yifan Jiang; Feicong Zhou; Jinyi Li; Ming Lin; Jiayong Lin; Zhijie Wang (Bulletin of Engineering Geology and the Environment, 2022)

Psychroserpens luteolus sp. nov., isolated from Gelidium, reclassification of Ichthyenterobacterium magnum as Psychroserpens magnus comb. nov., Flavihalobacter algicola as Psychroserpens algicola comb. nov., Arcticiflavibacter luteus as Psychroserpens luteus comb. nov - Xiu-Ya Ping; Kai Wang; Jin-Yu Zhang; Shu-Xin Wang; Zong-Jun Du; Da-Shuai Mu (Archives of Microbiology, 2022)

The dynamic behavior of calcareous sand under actual seismic loading - Hai-Ping Wang; Meng Gao; Ying Wang; Qing-Sheng Chen (Arabian Journal of Geosciences, 2022)

A novel mitochondrial genome haplotype in Parantica sita sita (Lepidoptera: Nymphalidae: Danainae) indicates substantial intraspecific genetic divergence - Yifan Zhang; Liangzhi Lu; Ping Hu; Di Wang; Rongjiang Wang (Applied Entomology and Zoology, 2022)

Understanding the impact of climatic variability on terrestrial water storage in the Qinghai-Tibet Plateau of China - Jingkai Xie; Yue-Ping Xu; Yuxue Guo; Yitong Wang; Hao Chen (Hydrological Sciences Journal, 2022)

Two new dammarane-type triterpenoids from the green walnut husks of Juglans mandshurica Maxim - Yuan-Yuan Zhou; Hui-Rui Gao; Hong-Juan Song; Dan-Da Ma; Xiao-Juan Zhang; Yan-Ping Sun; Yan Liu; Xiao-Li Wang; Bing-You Yang; Hai-Xue Kuang (Natural Product Research, 2022)

Five new phloroglucinol derivatives from Syzygium brachyantherum and their α -glucosidase and PTP1B inhibitory activities - Wen Xu; Shao-Hua Xu; Li Wang; Zhen Zang; Yan Zhao; Jing-Ping Liu; Jing Yang; Yong Zhao (Natural Product Research, 2022)

Consolidation behavior and microstructure properties of cement-treated dredged soil during the stress curing - Xingxing He; Yijun Chen; Yuan Li; Dongdong Guo; Qiang Xue; Shiquan Wang; Ping Wang; Yong Wan; Lei Liu (Marine Georesources & Geotechnology, 2022)

Dissection of the practical soybean breeding pipeline by developing ZDX1, a high-throughput functional array - Rujian Sun; Bincheng Sun; Yu Tian; Shanshan Su; Yong Zhang; Wanhai Zhang; Jingshun Wang; Ping Yu; Bingfu Guo; Huihui Li; Yanfei Li; Huawei Gao; et al. (Theoretical and Applied Genetics, 2022)
Key message We developed the ZDX1 high-throughput functional soybean array for high accuracy evaluation and selection of both parents and progeny, which can greatly accelerate soybean breeding. Abstract Microarray technology facilitates rapid, accurate, and economical genotyping. Here, using resequencing data from 2214 representative soybean accessions, we developed the high-throughput functional array ZDX1, containing 158,959 SNPs, covering 90.92% of soybean genes and sites related to important traits. By application of the array, a total of 817 accessions were genotyped, including three subpopulations of candidate parental lines, parental lines and their progeny from practical breeding. The fixed SNPs were identified in progeny, indicating artificial selection during the breeding process. By identifying functional sites of target traits, novel soybean cyst nematode-resistant progeny and maturity-related novel sources were identified by allele combinations, demonstrating that functional sites provide an efficient method for the rapid screening of desirable traits or gene sources. Notably, we found that the breeding index (BI) was a good indicator for progeny selection. Superior progeny were derived from the combination of distantly related parents, with at least one parent having a higher BI. Furthermore, new combinations based on good performance were proposed for further breeding after excluding redundant and closely related parents. Genomic best linear unbiased prediction (GBLUP) analysis was the best analysis method and achieved the highest accuracy in predicting four traits when comparing SNPs in genic regions rather than whole genomic or intergenic SNPs. The prediction accuracy was improved by 32.1% by using progeny to expand the training population. Collectively, a versatile assay demonstrated that the functional ZDX1 array provided efficient information for the design and optimization of a breeding pipeline for accelerated soybean breeding.

Fine mapping of powdery mildew resistance gene MlWE74 derived from wild emmer wheat (Triticum turgidum ssp. dicoccoides) in an NBS-LRR gene cluster - Keyu Zhu; Miaomiao Li; Haibin Wu; Deyun Zhang; Lingli Dong; Qiuhong Wu; Yongxing Chen; Jingzhong Xie; Ping Lu; Guanghao Guo; Huaizhi Zhang; Panpan Zhang; et al. (Theoretical and Applied Genetics, 2022)

OsFLA1 encodes a fasciclin-like arabinogalactan protein and affects pollen exine development in rice - Yao Deng; Yingchun Wan; Weichi Liu; Lisha Zhang; Kai Zhou; Ping Feng; Guanghua He; Nan Wang (Theoretical and Applied Genetics, 2022)

Moment Tensor Inversion and Stress Evolution of Coal Pillar Failure Mechanism - Chun-Hui Song; Cai-Ping Lu; Xiu-Feng Zhang; Chao Wang; Hua-Dong Xie; Xian-Yang Yan; Hong-Wei Yang (Rock Mechanics and Rock Engineering, 2022)

Autophagy modulation in resveratrol protective effects on steroidogenesis in high-fat diet-fed mice and H2O2-challenged TM3 cells - Ping Wang; Mengyu Lin; Chao Chen; Zheng-mei Lv (Molecular Biology Reports, 2022)

The role of Rho/ROCK in epileptic seizure-related neuronal damage - Zhihan Wang; Dabin Ren; Ping Zheng (Metabolic Brain Disease, 2022)
Epilepsy is one of the most severe neurological disorders characterized by spontaneous recurrent seizures. Although more than two-thirds of patients can be cured with anti-epileptic drugs (AEDs), the rest one-third of epilepsy patients are resistant to AEDs. A series of studies have demonstrated Rho/Rho-associated kinase (ROCK) pathway might be involved in the pathogenesis of epilepsy in the recent twenty years. Several related pathway inhibitors of Rho/ROCK have been used in the treatment of epilepsy. We searched PubMed from Jan 1, 2000 to Dec 31, 2020, using the terms "epilepsy AND Rho AND ROCK" and "seizure AND Rho AND ROCK". We selected articles that characterized Rho/ROCK in animal models of epilepsy and patients. We then chose the most relevant research studies including in-vitro , in-vivo and clinical trials. The expression of Rho/ROCK could be a potential non-invasive biomarker to apply in treatment for patients with epilepsy. RhoA and ROCK show significant upregulation in the acute and chronic stage of epilepsy. ROCK inhibitors can reduce the epilepsy, epileptic seizure-related neuronal death and comorbidities. These findings demonstrate the novel development for diagnosis and treatment for patients with epilepsy. Rho/ROCK signaling pathway inhibitors may show more promising effects in epilepsy and related neurological diseases.

Dynamics of nitrogen and phosphorus profile and its driving forces in a subtropical deep reservoir - Cunli Li; Ping Zhang; Guangwei Zhu; Chao Chen; Yucheng Wang; Mengyuan Zhu; Hai Xu; Cuiling Jiang; Wei Zou; Pengcheng Shi; Qing Zheng (Environmental Science and Pollution Research, 2022)

Association between congenital heart defects and maternal manganese and iron concentrations: a case–control study in China - Meixian Wang; Yan Tian; Ping Yu; Nana Li; Ying Deng; Lu Li; Hong Kang; Dapeng Chen; Hui Wang; Zhen Liu; Juan Liang (Environmental Science and Pollution Research, 2022)
To investigate the correlation between maternal manganese and iron concentrations and the risk of CHD among their infant. A multi-center hospital-based case control study was conducted in China. There were 322 cases and 333 controls have been selected from pregnant women who received prenatal examinations. Correlations between CHDs and maternal manganese and iron concentrations were estimated by conditional logistic regression. Moreover, the interaction between manganese and iron on CHDs was analyzed. Compared with the controls, mothers whose hair manganese concentration was 3.01 μg/g or more were more likely to have a child with CHD than those with a lower concentration. The adjusted OR was 2.68 (95%CI = 1.44–4.99). The results suggested that mothers whose iron content was 52.95 μg/g or more had a significantly higher risk of having a child with CHD ( aOR = 2.87, 95%CI = 1.54–5.37). No interaction between maternal manganese and iron concentrations was observed in the multiplicative or additive model. The concurrently existing high concentration of manganese and iron may bring higher risk of CHD ( OR = 7.02). Women with excessive manganese concentrations have a significantly increased risk of having offspring with CHDs. The high maternal iron status also correlates with CHDs. The concurrently existing high concentration of manganese and iron may bring higher risk of CHD.

Stability properties of natural estrogen conjugates in different aqueous samples at room temperature and tips for sample storage - Jun Zhang; Yi-ping Wan; Ze-hua Liu; Hao Wang; Zhi Dang; Yu Liu (Environmental Science and Pollution Research, 2022)

The impact of environmental regulations on export trade at provincial level in China: evidence from panel quantile regression - Ouyang Qiang; Wang Tian-tian; Deng Ying; Li Zhu-ping; Atif Jahanger (Environmental Science and Pollution Research, 2022)

Expression of l-phosphinothricin synthesis enzymes in Pichia pastoris for synthesis of l-phosphinothricin - Yu-Ke Cen; Qi Wang; Huo Gong; Ya-Ping Xue; Yu-Guo Zheng (Biotechnology Letters, 2022)

Activated Nrf-2 Pathway by Vitamin E to Attenuate Testicular Injuries of Rats with Sub-chronic Cadmium Exposure - Zhuo Chen; Zhicai Zuo; Kejie Chen; Zhuangzhi Yang; Fengyuan Wang; Jing Fang; Hengmin Cui; Hongrui Guo; Ping Ouyang; Zhengli Chen; Chao Huang; Yi Geng; et al. (Biological Trace Element Research, 2022)

The genetic engineering of glycine betaine synthesis in tobacco improves the resistance of the photosynthetic apparatus to drought stress - Gui-Ping Wang; Xiao-Min Xue; Xing-hong Yang; Ru Chen; Xue-Ping Han (Plant Biotechnology Reports, 2022)

Reduction research on performance index system of satellite navigation system spoofing - Yue Wang; Fu-Ping Sun; Jin-Ming Hao; Lun-Dong Zhang; Xian Wang (GPS Solutions, 2022)

Epigenetic inactivation of ACAT1 promotes epithelial-mesenchymal transition of clear cell renal cell carcinoma - Peipei Han; Shu Wu; Limei Li; Danping Li; Jun Zhao; Haishan Zhang; Yifang Wang; Xuemin Zhong; Zhe Zhang; Ping Li; Liudmila Matskova; Xiaoying Zhou (Genes & Genomics, 2022)

Complete genome sequence of a novel arlivirus from a yellow spotted stink bug (Erthesina fullo (Thunberg, 1783)) - Zhuang-Xin Ye; Shao-Min Wang; Gang Lu; Jian-Ping Chen; Chuan-Xi Zhang; Liao-Yuan Xu; Jun-Min Li (Archives of Virology, 2022)

Imatinib-induced hepatotoxicity via oxidative stress and activation of NLRP3 inflammasome: an in vitro and in vivo study - Feng-Ru Huang; Wen-Tong Fang; Zi-Ping Cheng; Ye Shen; Dun-Jian Wang; Yong-Qing Wang; Lu-Ning Sun (Archives of Toxicology, 2022)

The Predictability of Ocean Environments that Contributed to the 2020/21 Extreme Cold Events in China: 2020/21 La Niña and 2020 Arctic Sea Ice Loss - Fei Zheng; Ji-Ping Liu; Xiang-Hui Fang; Mi-Rong Song; Chao-Yuan Yang; Yuan Yuan; Ke-Xin Li; Ji Wang; Jiang Zhu (Advances in Atmospheric Sciences, 2022)
Several consecutive extreme cold events impacted China during the first half of winter 2020/21, breaking the low-temperature records in many cities. How to make accurate climate predictions of extreme cold events is still an urgent issue. The synergistic effect of the warm Arctic and cold tropical Pacific has been demonstrated to intensify the intrusions of cold air from polar regions into middle-high latitudes, further influencing the cold conditions in China. However, climate models failed to predict these two ocean environments at expected lead times. Most seasonal climate forecasts only predicted the 2020/21 La Niña after the signal had already become apparent and significantly underestimated the observed Arctic sea ice loss in autumn 2020 with a 1–2 month advancement. In this work, the corresponding physical factors that may help improve the accuracy of seasonal climate predictions are further explored. For the 2020/21 La Niña prediction, through sensitivity experiments involving different atmospheric–oceanic initial conditions, the predominant southeasterly wind anomalies over the equatorial Pacific in spring of 2020 are diagnosed to play an irreplaceable role in triggering this cold event. A reasonable inclusion of atmospheric surface winds into the initialization will help the model predict La Niña development from the early spring of 2020. For predicting the Arctic sea ice loss in autumn 2020, an anomalously cyclonic circulation from the central Arctic Ocean predicted by the model, which swept abnormally hot air over Siberia into the Arctic Ocean, is recognized as an important contributor to successfully predicting the minimum Arctic sea ice extent.

Preparation and In Vitro and In Vivo Evaluation of a Testosterone Film Forming Gel for the Treatment of Hypoactive Sexual Desire Disorder in Women - Jia Zeng; Tan-Fang Xie; Ting Huang; Fang Li; Zhi-Ping Wang; Ling-Lin Feng (AAPS PharmSciTech, 2022)

Microplastic Contamination on the Beaches of South China - Bingwen Chai; Yanping Li; Li Wang; Xiao-Tan Zhang; Yi-Ping Wan; Fengyuan Chen; Jie Ma; Wenlu Lan; Ke Pan (Frontiers in Marine Science, 2022)
Microplastics (MPs) have emerged as a pollutant of significant global concern. The sandy beach is a fragile environment that deserves our special attention with regard to MP contamination, as this area is a hotspot that accumulates large quantities of plastic waste. Notably, our current understanding of the MP distribution on beaches and the scale of contamination is far from sufficient. Hence, this study investigated the occurrence and characteristics of MPs on 14 beaches along the coast of South China. The MPs were ubiquitously distributed in the sand, most were small, less than 1 mm. A total of 18 types of polymers were identified in the sand, suggesting that diverse types of MPs are present on the beaches. Polyethylene, polypropylene, and polystyrene were the dominant types of MPs in most of our sampling sites. The MP abundance was higher in the upper layers (0–20 cm) of the beach than in the deeper layers (20–40 cm) of the sampling site when characterized by depth (Yangjiang beach). Our study demonstrates the extent and severity of MP pollution on the beaches of South China and provides implications for future remediation measures. More effort is needed to clarify the vertical distribution of MPs on beaches, especially for those MPs less than 1 μm.

Four new resorcinol derivatives with neuroprotective activities from Xylaria nigripes - Lan-Qing Li; Jing Li; Hong-Ping Long; Ji-Kai Liu; Xian Wang (Natural Product Research, 2022)

Potent immunosuppressive and anti-inflammatory bisindole alkaloids from Melodinus fusiformis - Lu Liu; Ming-Jun Xie; Wen-Bing Zhou; Jin-Tang Wang; Jia-Yi Wang; Afsar Khan; Ya-Ping Liu; Jian-Xin Cao; Gui-Guang Cheng; Wen-Yuan Mao (Natural Product Research, 2022)

Comparative Analysis of Blood Transcriptome in the Yangtze Finless Porpoise (Neophocaena asiaeorientalis) - Di-An Fang; Kai Liu; Dong-Po Xu; Yin-Ping Wang; Pao Xu (Fishes, 2022)
The Yangtze finless porpoise (Neophocaena asiaeorientalis) is the sole freshwater subspecies of Neophocaenaphocaenoides, and there is a lack of data on its transcriptome. In this study, we applied RNA-seq technology to assemble, de novo, a transcriptome and analyzed differential expressed genes (DEGs). About 6 Gb of clean data was generated for the Yangtze finless porpoise blood (n = 6) through de novo sequencing. In total, 151,211 unigenes were generated and a total of 119,039 of these unigenes (78.72%) were functionally annotated when searched for within the NCBI Nr, SwissProt, GO, COG, and KEGG databases. Diverse and extensive expressed gene catalogs were sampled for the Yangtze finless porpoise. DESeq2 was used to analyze the differential expression genes (DEGs) obtained from the assembled transcriptome. The results indicated that DEGs have close relationships with the Yangtze finless porpoise’s development, evolution and adaptation. Further, we found that genes involved in cetacean TAG synthesis might directly explain the molecular basis of cetacean blubber thickening. These transcriptome data will assist in understanding molecular mechanisms of Yangtze finless porpoise adaptation.

OsMYB103 is essential for tapetum degradation in rice - Ting Lei; Lisha Zhang; Ping Feng; Yang Liu; Wuzhong Yin; Lina Shang; Guanghua He; Nan Wang (Theoretical and Applied Genetics, 2022)

Research on Mechanisms and Precursors of Slip and Fracture of Coal–Rock Parting–Coal Structure - Zhi-Long He; Cai-Ping Lu; Xiu-Feng Zhang; Ying Guo; Chao Wang; Heng Zhang; Bao-Qi Wang (Rock Mechanics and Rock Engineering, 2022)

A Data-Intensive Numerical Modeling Method for Large-Scale Rock Strata and Its Application in Mining Subsidence Prediction - Ya-Qiang Gong; Guang-Li Guo; Li-Ping Wang; Huai-Zhan Li; Guang-Xue Zhang; Zhen Fang (Rock Mechanics and Rock Engineering, 2022)

Transcriptomic analyses reveal the effect of nitric oxide on the lateral root development and growth of mangrove plant Kandelia obovata - Ming-Yue Wei; Huan Li; You-Hui Zhong; Zhi-Jun Shen; Dong-Na Ma; Chang-Hao Gao; Yi-Ling Liu; Wen-Hua Wang; Jing-Ya Zhang; Yan-Ping You; Hai-Lei Zheng (Plant and Soil, 2022)

Probabilistic prediction of the spatial distribution of potential key blocks during tunnel surrounding rock excavation - Peng He; Li-ping Li; Gang Wang; Fei Xu; Shang-qu Sun (Natural Hazards, 2022)

Experimental investigation of propagation and run-up of rockslide- generated impulse waves in a curved mountain reservoir - Linfeng Han; Pingyi Wang; Ping Mu; Qingyang Ren; Yun Liu (Natural Hazards, 2022)

Hippocampal SIRT1-Mediated Synaptic Plasticity and Glutamatergic Neuronal Excitability Are Involved in Prolonged Cognitive Dysfunction of Neonatal Rats Exposed to Propofol - Lin-Hui Ma; Jie Wan; Jing Yan; Ning Wang; Yan-Ping Liu; Hai-Bi Wang; Cheng-Hua Zhou; Yu-Qing Wu (Molecular Neurobiology, 2022)

Best practices for analyzing imputed genotypes from low-pass sequencing in dogs - Reuben M. Buckley; Alex C. Harris; Guo-Dong Wang; D. Thad Whitaker; Ya-Ping Zhang; Elaine A. Ostrander (Mammalian Genome, 2022)
Although DNA array-based approaches for genome-wide association studies (GWAS) permit the collection of thousands of low-cost genotypes, it is often at the expense of resolution and completeness, as SNP chip technologies are ultimately limited by SNPs chosen during array development. An alternative low-cost approach is low-pass whole genome sequencing (WGS) followed by imputation. Rather than relying on high levels of genotype confidence at a set of select loci, low-pass WGS and imputation rely on the combined information from millions of randomly sampled low-confidence genotypes. To investigate low-pass WGS and imputation in the dog, we assessed accuracy and performance by downsampling 97 high-coverage (> 15×) WGS datasets from 51 different breeds to approximately 1× coverage, simulating low-pass WGS. Using a reference panel of 676 dogs from 91 breeds, genotypes were imputed from the downsampled data and compared to a truth set of genotypes generated from high-coverage WGS. Using our truth set, we optimized a variant quality filtering strategy that retained approximately 80% of 14 M imputed sites and lowered the imputation error rate from 3.0% to 1.5%. Seven million sites remained with a MAF > 5% and an average imputation quality score of 0.95. Finally, we simulated the impact of imputation errors on outcomes for case–control GWAS, where small effect sizes were most impacted and medium-to-large effect sizes were minorly impacted. These analyses provide best practice guidelines for study design and data post-processing of low-pass WGS-imputed genotypes in dogs.

Fate of heavy metals and bacterial community composition following biogas slurry application in a single rice cropping system - Qiang Wang; Zhaoming Chen; Jun Zhao; Junwei Ma; Qiaogang Yu; Ping Zou; Hui Lin; Jinchuan Ma (Journal of Soils and Sediments, 2022)

The association between environmental exposure to perchlorate, nitrate, and thiocyanate and all-cause and cause-specific mortality - Long Wang; Zhi Fu; Beibei Gao; Xuming Mo; Ping Liang; Jinyu Huang (Environmental Science and Pollution Research, 2022)

Biological monitoring and health assessment of 21 metal(loid)s in children and adolescents in Liuzhou City, Southwest China - Yaping Li; Yu Zhang; Meng Yu; Liqin Hu; Ting Zeng; Ling Liu; Limei Wang; Liangqiong Deng; Xiang Li; Ping Liu; Dingyuan Zeng; Surong Mei (Environmental Science and Pollution Research, 2022)

Time series analysis of short-term effects of particulate matter pollution on the circulatory system disease mortality risk in Lishui District, China - Xudan Zhou; Ce Wang; Ping Chen; Yuqi Chen; Lihong Yin; Wei Du; Yuepu Pu (Environmental Science and Pollution Research, 2022)

Correlation assessment of NDVI and land use dynamics with water resources for the southern margin of Mu Us Sandy Land, China - Menglong Zhao; Yu Wang; Siyuan Liu; Ping-an Zhong; Hongzhen Liu; Rongrong Li (Environmental Science and Pollution Research, 2022)

Removal of SO2 from flue gas using blast furnace dust as an adsorbent - Binghua Xie; Na Geng; Qian Yu; Di He; Fang Wang; Tiancheng Liu; Jiyun Gao; Ping Ning; Xin Song; Lijuan Jia (Environmental Science and Pollution Research, 2022)

Is Zooplankton Body Size an Indicator of Water Quality in (Sub)tropical Reservoirs in China? - Li Wang; Jun Chen; Haojie Su; Xufa Ma; Zhixu Wu; Hong Shen; Jia Yu; Jiarui Liu; Yao Wu; Guangyi Ding; Ping Xie (Ecosystems, 2022)

The tyrosine kinase inhibitor LPM4870108 impairs learning and memory and induces transcriptomic and gene‑specific DNA methylation changes in rats - Sijin Duan; Chunmei Li; Yonglin Gao; Ping Meng; Shengmin Ji; Yangyang Xu; Yutong Mao; Hongbo Wang; Jingwei Tian (Archives of Toxicology, 2022)

Experiment on the energy damage development process of water-saturated limestone under varied loading rates - Peng Li; Yongjian Zhu; Ping Wang; Heng Ren; Mingxing Wei; Xizhi Wang (Arabian Journal of Geosciences, 2022)

MoOpy2 is essential for fungal development, pathogenicity, and autophagy in Magnaporthe oryzae - Ying‐Ying Cai; Jing‐Yi Wang; Xi‐Yu Wu; Shuang Liang; Xue‐Ming Zhu; Lin Li; Jian‐Ping Lu; Xiao‐Hong Liu; Fu‐Cheng Lin (Environmental Microbiology, 2022)
Summary The development and pathogenicity of the fungus Magnaporthe oryzae , the causal agent of destructive rice blast disease, require it to perceive external environmental signals. Opy2, an overproduction‐induced pheromone‐resistant protein 2, is a crucial protein for sensing external signals in Saccharomyces cerevisiae . However, the biological functions of the homologue of Opy2 in M. oryzae are unclear. In this study, we identified that MoOPY2 is involved in fungal development, pathogenicity, and autophagy in M. oryzae . Deletion of MoOPY2 resulted in pleiotropic defects in hyphal growth, conidiation, germ tube extension, appressorium formation, appressorium turgor generation, and invasive growth, therefore leading to attenuated pathogenicity. Furthermore, MoOpy2 participates in the Osm1 MAPK pathway and the Mps1 MAPK pathway by interacting with the adaptor protein Mst50. The interaction sites of Mst50 and MoOpy2 colocalized with the autophagic marker protein MoAtg8 in the preautophagosomal structure sites (PAS). Notably, the Δ Moopy2 mutant caused cumulative MoAtg8 lipidation and rapid GFP‐MoAtg8 degradation in response to nitrogen starvation, showing that MoOpy2 is involved in the negative regulation of autophagy activity. Taken together, our study revealed that MoOpy2 of M. oryzae plays an essential role in the orchestration of fungal development, appressorium penetration, autophagy and pathogenesis.

Four new prenylflavonol glycosides from the leaves of Cyclocarya paliurus - Zi-Jun Ye; Hui-Hui Sun; Zu-Hui Chen; Jian-Ping Wu; Jing Li; Hui Zhu; Lu-Lu Huang; Xi-Wen Chang; Sai-Yu Ou; Wen-Xuan Wang; Xiao-Ai He; Gang-Zhi Zhu; et al. (Natural Product Research, 2022)

Asian monsoon projection with a new large-scale monsoon definition - Xingang Dai; Yang Yang; Ping Wang (Theoretical and Applied Climatology, 2022)
This paper focuses on Asian monsoon projection with CMIP5 multi-model outputs. A large-scale monsoon herewith is defined as a vector field of vertically integrated moisture flux from the surface to 500 hPa. Results demonstrate that the model ensemble mean underestimated the summer monsoon and overestimated slightly the winter monsoon over South Asia in both CMIP5 historical climate simulation and the monsoon projection for 2006–2015. The major of the bias is the model climate drift (MCD), which is removed in the monsoon projection for 2016–2045 under scenarios RCP4.5 for reducing the uncertainty. The projection shows that two increased moisture flows northward appeared across the Equator of Indian Ocean, the first is nearby Somalia coast toward northwestern part of South Asia, leading to excess rainfall in where the wet jet could reach, and the second starts from the equatorial Sect. (80°E–100°E) toward northeastern Bay of Bengal, leading to more rainfall spreading over the northwestern coast of Indochina Peninsula. In addition, a westward monsoon flow is intensified over the Peninsula leading to local climate moisture transport belt shifted onto South China Sea, which would reduce moisture transport toward Southwest China on one hand, and transport more moisture onto the southeast coast of the China mainland. The anomalous monsoon would result in a dry climate in Northwest China and wet climate in the coast belt during summer monsoon season for the period. Besides, the Asian winter monsoon would be seemingly intensified slightly over South Asia, which would bring a dry winter climate to Indian subcontinent, Northwest China, but would be more rainfall in southeast part of Arabian Peninsula with global climate warming.

A framework for determining lowest navigable water levels with nonstationary characteristics - Lu Wang; Ping Xie; Chong-Yu Xu; Yan-Fang Sang; Jie Chen; Tao Yu (Stochastic Environmental Research and Risk Assessment, 2022)

A comparison of the reproducibility of regional precipitation properties simulated respectively by weather generators and stochastic simulation methods - Luhua Yang; Ping-an Zhong; Feilin Zhu; Yufei Ma; Han Wang; Jieyu Li; Chengjing Xu (Stochastic Environmental Research and Risk Assessment, 2022)

Cancer metabolism and tumor microenvironment: fostering each other? - Yiyuan Yuan; Huimin Li; Wang Pu; Leilei Chen; Dong Guo; Hongfei Jiang; Bo He; Siyuan Qin; Kui Wang; Na Li; Jingwei Feng; Jing Wen; et al. (Science China Life Sciences, 2022)

Estimation of nitrogen status of paddy rice at vegetative phase using unmanned aerial vehicle based multispectral imagery - Yi-Ping Wang; Yu-Chieh Chang; Yuan Shen (Precision Agriculture, 2022)

Plant-derived lignans as potential antiviral agents: a systematic review - Xin-Ya Xu; Dong-Ying Wang; Yi-Ping Li; Stephen T. Deyrup; Hong-Jie Zhang (Phytochemistry Reviews, 2022)

Necrostatin-1 Relieves Learning and Memory Deficits in a Zebrafish Model of Alzheimer’s Disease Induced by Aluminum - Xiaocheng Gao; Ping Zhang; Jianping Chen; Lan Zhang; Nan Shang; Jin Chen; Rong Fan; Yanhong Wang; Tao Huang; Qiao Niu; Qinli Zhang (Neurotoxicity Research, 2022)

Knockdown of circHECTD1 inhibits oxygen-glucose deprivation and reperfusion induced endothelial-mesenchymal transition - Guo-Hua He; Zhen Wang; Wei Xu; Kang-Ping Song; Hui Xiao (Metabolic Brain Disease, 2022)

Mass cultivation of conidia of Pyricularia oryzae - Zhong-na Hao; Hai-ping Qiu; Zhen Zhang; Rong-yao Chai; Shi-zhen Wang; Yan-li Wang; Jiao-yu Wang; Guo-chang Sun (Journal of Plant Pathology, 2022)

The effect of methyltestosterone (MT) on sex differentiation and growth in juvenile yellow perch (Perca flavescens) - Rafidah Othman; Xiao-Jun Ron; Hong Yao; Paul O’Bryant; Dean Rapp; Jing-Chen Pei; Hong-Juan Wu; Han-Ping Wang (Fish Physiology and Biochemistry, 2022)

Oxidative degradation/mineralization of dimethyl phthalate (DMP) from plastic industrial wastewater using ferrate(VI)/TiO2 under ultraviolet irradiation - Ping Wang; Yi Ding; Liting Zhu; Yunhao Zhang; Sijie Zhou; Linbei Xie; Ao Li (Environmental Science and Pollution Research, 2022)

Aberrant functional and effective connectivity of the frontostriatal network in unilateral acute tinnitus patients with hearing loss - Gang-Ping Zhou; Yu-Chen Chen; Wang-Wei Li; Heng-Le Wei; Yu-Sheng Yu; Qing-Qing Zhou; Xindao Yin; Yue-Jin Tao; Hong Zhang (Brain Imaging and Behavior, 2022)

Feature Construction and Identification of Convective Wind from Doppler Radar Data - Yuchen Bao; Juntao Xue; Di Wang; Yue Yuan; Ping Wang (Journal of Meteorological Research, 2022)

The settlement intention of urban-to-urban migrants in China: Spatial differences and driving factors - Xinming Wang; Wei Qi; Shenghe Liu; Zhen Liu; Ping Gao; Haoran Jin (Journal of Geographical Sciences, 2022)

Screening of Biological Target Molecules Related to Glucocorticoid-Induced Cataract (GIC) on the Basis of Constructing ceRNA Network - Zhan Shi; Xiumei Zhao; Ying Su; Chao Wang; Ping Liu; Hongyan Ge (Biochemical Genetics, 2022)

SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration - Zuo-long Wu; Ya-jun Chen; Guang-zhi Zhang; Qi-qi Xie; Ke-ping Wang; Xin Yang; Tai-Cong Liu; Zhi-qiang Wang; Guang-hai Zhao; Hai-Hong Zhang (Apoptosis, 2022)

Improving Water-Absorption and Mechanical Strength: Lyotropic Liquid Crystalline–Based Spray Dressings as a Candidate Wound Management System - Chen Wang; Jingtian Chen; Xiao Yue; Xiao Xia; Ziqiang Zhou; Guanlin Wang; Xuejuan Zhang; Ping Hu; Ying Huang; Xin Pan; Chuanbin Wu (AAPS PharmSciTech, 2022)

Eutrophication and predation mediate zooplankton diversity and network structure - Yun Li; Rong Wang; Haojie Su; Jianjun Wang; Ping Xie; Feizhou Chen (Limnology and Oceanography, 2022)
Anthropogenic activities such as eutrophication and fishing have prominent effects on freshwater ecosystems. However, the ways in which ecosystem function and biodiversity respond to multiple drivers from eutrophication and top‐down predation remains inconclusive. We studied zooplankton communities in 102 subtropical shallow lakes in the eastern plain of China and further examined the joint effects of nutrient enrichment and predation on biodiversity and ecological networks. We found that alpha diversity was negatively influenced by nutrient conditions (such as total phosphorus and total nitrogen [TN]), whereas beta diversity (β‐diversity) was positively related to nutrients and was also structured by omnivorous fish showing a unimodal pattern. Furthermore, the network skewness of zooplankton increased with nutrient enrichment, especially TN, and was negatively related to omnivorous fish. This skewness is more sensitive than β‐diversity, whereas negative skew is primarily caused by omnivorous fish. Our results demonstrated that top‐down effects were dominant for zooplankton communities and resulted in structural adjustment of zooplankton communities, mainly with an increase in fish predation. A negative skewed network indicates the presence of more generalist species and stronger connections among the zooplankton assemblages, as well as decreased β‐diversity.

Tropical tall forests are more sensitive and vulnerable to drought than short forests - Liyang Liu; Xiuzhi Chen; Philippe Ciais; Wenping Yuan; Fabienne Maignan; Jin Wu; Shilong Piao; Ying‐Ping Wang; Jean‐Pierre Wigneron; Lei Fan; Pierre Gentine; Xueqin Yang; et al. (Global Change Biology, 2022)
Our limited understanding of the impacts of drought on tropical forests significantly impedes our ability in accurately predicting the impacts of climate change on this biome. Here, we investigated the impact of drought on the dynamics of forest canopies with different heights using time‐series records of remotely sensed Ku‐band vegetation optical depth (Ku‐VOD), a proxy of top‐canopy foliar mass and water content, and separated the signal of Ku‐VOD changes into drought‐induced reductions and subsequent non‐drought gains. Both drought‐induced reductions and non‐drought increases in Ku‐VOD varied significantly with canopy height. Taller tropical forests experienced greater relative Ku‐VOD reductions during drought and larger non‐drought increases than shorter forests, but the net effect of drought was more negative in the taller forests. Meta‐analysis of in situ hydraulic traits supports the hypothesis that taller tropical forests are more vulnerable to drought stress due to smaller xylem‐transport safety margins. Additionally, Ku‐VOD of taller forests showed larger reductions due to increased atmospheric dryness, as assessed by vapor pressure deficit, and showed larger gains in response to enhanced water supply than shorter forests. Including the height‐dependent variation of hydraulic transport in ecosystem models will improve the simulated response of tropical forests to drought.

Oxidation of organoarsenicals and antimonite by a novel flavin monooxygenase widely present in soil bacteria - Jun Zhang; Jian Chen; Yi‐Fei Wu; Zi‐Ping Wang; Ji‐Guo Qiu; Xiao‐Long Li; Feng Cai; Ke‐Qing Xiao; Xiao‐Xu Sun; Barry P. Rosen; Fang‐Jie Zhao (Environmental Microbiology, 2022)
Summary Arsenic can be biomethylated to form a variety of organic arsenicals differing in toxicity and environmental mobility. Trivalent methylarsenite (MAs(III)) produced in the methylation process is more toxic than inorganic arsenite (As(III)). MAs(III) also serves as a primitive antibiotic and, consequently, some environmental microorganisms have evolved mechanisms to detoxify MAs(III). However, the mechanisms of MAs(III) detoxification are not well understood. In this study, we identified an arsenic resistance ( ars ) operon consisting of three genes, arsRVK , that contribute to MAs(III) resistance in Ensifer adhaerens ST2. ArsV is annotated as an NADPH‐dependent flavin monooxygenase with unknown function. Expression of arsV in the arsenic hypersensitive Escherichia coli strain AW3110 Δars conferred resistance to MAs(III) and the ability to oxidize MAs(III) to MAs(V). In the presence of NADPH and either FAD or FMN, purified ArsV protein was able to oxidize both MAs(III) to MAs(V) and Sb(III) to Sb(V). Genes with arsV ‐like sequences are widely present in soils and environmental bacteria. Metagenomic analysis of five paddy soils showed the abundance of arsV ‐like sequences of 0.12–0.25 ppm. These results demonstrate that ArsV is a novel enzyme for the detoxification of MAs(III) and Sb(III) and the genes encoding ArsV are widely present in soil bacteria.

The Mechanism of Carbonate Alkalinity Exposure on Juvenile Exopalaemon carinicauda With the Transcriptome and MicroRNA Analysis - Kunpeng Shi; Mingdong Li; Zhen Qin; Jiajia Wang; Ping Liu; Jian Li; Jitao Li (Frontiers in Marine Science, 2022)
Saline-alkali water is distributed all over the world and affects the development of fisheries. The ridge tail white prawn Exopalaemon carinicauda is an economically important shrimp in China, which has excellent environmental tolerance. However, due to its complex genetic structure, there have been few studies on its alkalinity-adaptation mechanisms. In order to explore the molecular mechanisms of E. carinicauda in adapting to the alkaline water, mRNA and miRNA transcriptomes from the gills of E. carinicauda were determined. The results showed that after alkalinity stress, the structures of the gill and hepatopancreas were disorganized; however, E. carinicauda could still maintain vital signs. Transcriptome results showed that ATP binding protein and carbonic anhydrase played an important role in alkalinity-adaptation. At the same time, a large number of immune-related genes were up-regulated, which protect E. carinicauda from bacterial infection. MiRNAs also played an important role in alkalinity-adaptation. A total of 24 miRNAs were identified as differentially expressed after alkalinity stress, and up-regulated miRNAs might active the GnRH signaling pathway and accelerate the synthesis and secretion of aldosterone, which might maintain the balance of osmotic pressure in E. carinicauda to adapt to alkaline environment. These results provide a better understanding of the alkalinity-adaptation mechanism of economic aquatic animals and provide theoretical basis for breeding in the future.

Characterization of alkaloids in radix Sophora tonkinensis by UPLC-Q-TOF-MS/MS and its application in the comparison of two different habitats - Xing-Xing Zong; Yu Wang; Jia-Liang Xiong; Yu-Hui Ping; Qiong-Lin Liang (Natural Product Research, 2022)

PCSK9 mediates dyslipidemia induced by olanzapine treatment in schizophrenia patients - Jing Huang; Jingmei Xiao; Zhuang Peng; Ping Shao; Mengxi Sun; Yujun Long; Xiaoyi Wang; Manjun Shen; Dongyu Kang; Ye Yang; Xingjie Peng; Weiyan Wang; et al. (Psychopharmacology, 2022)

Association of Increased Amygdala Activity with Stress-Induced Anxiety but not Social Avoidance Behavior in Mice - Shou-He Huang; Wei-Zhu Liu; Xia Qin; Chen-Yi Guo; Qing-Cheng Xiong; Yu Wang; Ping Hu; Bing-Xing Pan; Wen-Hua Zhang (Neuroscience Bulletin, 2022)

Effects of environmental factors on plant functional traits across different plant life forms in a temperate forest ecosystem - Xiaoqin Cheng; Tain Ping; Zuzheng Li; Tian Wang; Hairong Han; Howard E. Epstein (New Forests, 2022)