Combined effects of predicted climate and land use changes on future hydrological droughts in the Luanhe River basin, China - Xu Chen; Ruiguang Han; Ping Feng; Yongjie Wang (Natural Hazards, 2022)

A community effort to assess and improve computerized interpretation of 12-lead resting electrocardiogram - Zijian Ding; Guijin Wang; Huazhong Yang; Ping Zhang; Dapeng Fu; Zhen Yang; Xinkang Wang; Xia Wang; Zhourui Xia; Chiming Zhang; Wenjie Cai; Binhang Yuan; et al. (Medical & Biological Engineering & Computing, 2022)
Computerized interpretation of electrocardiogram plays an important role in daily cardiovascular healthcare. However, inaccurate interpretations lead to misdiagnoses and delay proper treatments. In this work, we built a high-quality Chinese 12-lead resting electrocardiogram dataset with 15,357 records, and called for a community effort to improve the performances of CIE through the China ECG AI Contest 2019. This dataset covers most types of ECG interpretations, including the normal type, 8 common abnormal types, and the other type which includes both uncommon abnormal and noise signals. Based on the Contest, we systematically assessed and analyzed a set of top-performing methods, most of which are deep neural networks, with both their commonalities and characteristics. This study establishes the benchmarks for computerized interpretation of 12-lead resting electrocardiogram and provides insights for the development of new methods.

Effect of biochar aging on the adsorption and stabilization of Pb in soil - Dandan Chen; Wenhui Liu; Yuxuan Wang; Ping Lu (Journal of Soils and Sediments, 2022)

The difference in the intracellular Arg/Lys-rich and EHLVY motifs contributes to distinct subcellular distribution of HAI-1 versus HAI-2 - Nanxi Huang; Robert B. Barndt; Dajun D. Lu; Qiaochu Wang; Shih-Ming Huang; Jehng-Kang Wang; Ping-Ying Chang; Chao-Yang Chen; Je-Ming Hu; Hui-Chen Su; Michael D. Johnson; Chen-Yong Lin (Human Cell, 2022)

Endophytes Bacillus amyloliquefaciens AW3 (CGMCC1.16683) improves the growth of Populus davidiana × Populus bolleana (PdPap) and induces its resistance to wilt disease by Fusarium oxysporum Fox68 (CFCC86068) - Ping Zhang; Haotian Hao; Lihai Wang; Zhihua Liu; Ling Ma (European Journal of Plant Pathology, 2022)

Coupling isotopic analysis and Ecopath model to detect the ecosystem features based on functional groups of the southwestern Yellow Sea, China - Wei Wang; Ping Zuo; Junjie Wang (Environmental Science and Pollution Research, 2022)

Association between serum folate levels and blood concentrations of cadmium and lead in US adults - Zuxiang Wu; Huan Hu; Chenxi Wang; Ji Wu; Yurong Xiong; Yang Fu; Xiaoshu Cheng; Hai Su; Ping Li (Environmental Science and Pollution Research, 2022)

Performance and mechanisms of fly ash for graphene oxide removal from aqueous solution - Ping Jiang; Lin Zhou; Wei Wang; Na Li; Fang Zhang (Environmental Science and Pollution Research, 2022)

The combined toxicity and mechanism of multi-walled carbon nanotubes and nano zinc oxide toward the cabbage - Mo Hong; Ji-Lai Gong; Wei-Cheng Cao; Rong Fang; Zhe Cai; Jun Ye; Zeng-Ping Chen; Wang-Wang Tang (Environmental Science and Pollution Research, 2022)

Green synthesis of a novel functionalized chitosan adsorbent for Cu(II) adsorption from aqueous solution - Fang Wang; Jiyun Gao; Lijuan Jia; Shixing Wang; Ping Ning (Environmental Science and Pollution Research, 2022)

RETRACTED ARTICLE: Co-delivery of doxorubicin and SIS3 by folate-targeted polymeric micelles for overcoming tumor multidrug resistance - Shuanghu Wang; Xueying Tan; Quan Zhou; Peiwu Geng; Jinhui Wang; Ping Zou; Aiping Deng; Jingbo Hu (Drug Delivery and Translational Research, 2022)

Fracture analysis of central-flawed rock-like specimens under the influence of coplanar or non-coplanar edge flaws - Zhizhen Liu; Ping Cao; Kaihui Li; Fei Wang; Tao Dong; Jingshuo Liu (Bulletin of Engineering Geology and the Environment, 2022)

Laser ablation inductively coupled plasma mass spectrometry analysis of Chinese lead-barium glass: combining multivariate kernel density estimation and maximum mean discrepancy to reinterpret the raw glass used for producing lead-barium glass - Qian Ma; Rui Wen; Yifan Yu; Long Wang; Man Li; Luwu Cai; Li Ping; Zhiqiang Zhao; Dong Wang; Xiang Wang; Ruoyu Shi; A. Mark Pollard (Archaeological and Anthropological Sciences, 2022)

Mitogenomes provide new insights into the evolutionary history of Prodiamesinae (Diptera: Chironomidae) - Xiao‐Long Lin; Yan‐Min Zhao; Li‐Ping Yan; Wen‐Bin Liu; Wen‐Jun Bu; Xin‐Hua Wang; Chen‐Guang Zheng (Zoologica Scripta, 2022)
Evolutionary analysis of Prodiamesinae has long been impeded by lack of information, and its phylogenetic relationship with Orthocladiinae remains questionable. Here, ten complete mitochondrial genomes (mitogenomes) of Orthocladiinae sensu lato were newly sequenced, including three Prodiamesinae species and seven Orthocladiinae species. Coupled with published mitogenomes, a total of 12 mitogenomes of Orthocladiinae sensu lato were selected for a comparative mitogenomic analysis and phylogenetic reconstruction. Mitogenomes of Orthocladiinae sensu lato are conserved in structure, and all genes arrange the same gene order as the ancestral insect mitogenome. Nucleotide composition is highly biased, and the control region displayed the highest A + T content. All protein‐coding genes are under purifying selection, and the ATP8 evolves at the fastest rate. In addition, the mitogenomes of Orthocladiinae sensu lato are highly conserved, and they are practically useful for phylogenetic inference, suggesting a re‐classification of Orthocladiinae by sinking Prodiamesinae as a subgroup of Orthocladiinae.

Nonlinear interactions of land carbon cycle feedbacks in Earth System Models - Yuanyuan Huang; Ying‐Ping Wang; Tilo Ziehn (Global Change Biology, 2022)
Carbon cycle feedbacks were often quantified through the carbon–concentration and carbon–climate feedbacks with the assumption of no significant interaction between the two feedbacks in most previous studies. Here we calculated the strength of the interactions between the two responses using simulations of models participated in the phase 6 of the Coupled Model Intercomparison Project (CMIP6). We found that the nonlinear interaction contributed 11% of the land–atmosphere carbon exchange on average with large intermodel variation (from −20% to +162%). This nonlinear interaction is largely driven by the pattern of net primary production (NPP), with shifts in heterotrophic respiration that dampen the overall positive interactions from NPP. Photosynthetic rate per unit leaf area alone cannot adequately explain a wide variation of interactions in global NPP simulated by CMIP6 models. Plant respiration and processes that regulate leaf area are also important contributors to the interactions. Dominant factors that induce carbon–concentration and carbon–climate interactions are highly variable among models. One of those dominant factors is nutrient limitation. Using additional simulations of ACCESS‐ESM1.5 that include both nitrogen and phosphorus limitation, we found that the estimated interactions by ACCESS‐ESM1.5 with or without nutrient limitations covered the large intermodel variations among the CMIP6 models. It remains largely unknown how nutrient limitation complicates ecosystem's responses to simultaneously CO 2 fertilization and warming at the global scale. Our modeling results point to a potential important role of nutrients, especially phosphorus on the nonlinear interactions. Yet, more studies are needed on ecosystem responses to concurrent changes in nutrient availability, atmospheric CO 2 concentration, and warming.

A thermophile Hydrogenibacillus sp. strain efficiently degrades environmental pollutants polycyclic aromatic hydrocarbons - Xiaoyu Qiu; Weiwei Wang; Lige Zhang; Lihua Guo; Ping Xu; Hongzhi Tang (Environmental Microbiology, 2022)
Summary Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants threatening ecosystems and human health. Here, we isolated and characterized a new strain, Hydrogenibacillus sp. N12, which is a thermophilic PAH‐degrader. Strain N12 utilizes naphthalene as a sole carbon and energy source above 60°C and co‐metabolizes many other PAHs as well. The metabolites were identified in the catabolism of naphthalene by gas chromatography–mass spectrometry (GC–MS) and stable isotopic analysis. Based on the identified metabolites, we proposed two possible metabolic pathways, one via salicylic acid and the other via phthalic acid. Whole‐genome sequencing reveals that strain N12 possesses a small chromosome of 2.6 Mb. Combining genetic and transcriptional information, we reveal a new gene cluster for the naphthalene degradation. The genes, designated as nar AaAb that are predicted to encode the alpha and beta subunits of naphthalene dioxygenase, were subsequently subcloned into Escherichia coli and the enzyme activity was detected by whole‐cell transformation. Capacity to degrade several other tricyclic‐PAHs was also characterized, suggesting co‐existence of other constitutively expressed enzyme systems in strain N12 in addition to the naphthalene degradation gene cluster. Our study provides insights into the potential of the thermophilic PAH‐degrader in biotechnology and environmental management applications.

Biogeography of culturable marine bacteria from both poles reveals that ‘everything is not everywhere’ at the genomic level - Qi‐Long Qin; Zhi‐Bin Wang; Qian‐Qian Cha; Sha‐Sha Liu; Xue‐Bing Ren; Hui‐Hui Fu; Mei‐Ling Sun; Dian‐Li Zhao; Andrew McMinn; Yin Chen; Xiu‐Lan Chen; Yu‐Zhong Zhang; et al. (Environmental Microbiology, 2022)
Summary Based on 16S rRNA gene analyses, the same bacterial operational taxonomic units (OTUs) are common to both the Arctic and Antarctic oceans, supporting the concept ‘everything is everywhere’. However, whether the same OTUs from both poles have identical genomes, i.e. whether ‘everything is still everywhere’ at the genomic level has not yet been examined systematically. Here, we isolated, sequenced and compared the genomes of 45 culturable marine bacteria belonging to three genera of Salinibacterium , Psychrobacter and Pseudoalteromonas from both polar oceans. The bacterial strains with identical 16S rRNA genes were common to both poles in every genus, and four identical genomes were detected in the genus Salinibacterium from the Arctic region. However, no identical genomes were observed from opposite poles in this study. Our data, therefore, suggest that ‘everything is not everywhere’ at the genomic level. The divergence time between bacteria is hypothesized to exert a strong impact on the bacterial biogeography at the genomic level. The geographical isolation between poles was observed for recently diverged, highly similar genomes, but not for moderately similar genomes. This study thus improves our understanding of the factors affecting the genomic‐level biogeography of marine microorganisms isolated from distant locations.

Ichthyoplankton Species Composition and Assemblages From the Estuary to the Hukou Section of the Changjiang River - Di-an Fang; Xiang-ping Xue; Dong-po Xu; Xiao-hao Wang; Ning-ze Sun; Bai-dong Zhang; Peng Ren (Frontiers in Marine Science, 2021)
Estuary river–lake (ERL) complex is critical for the development of ichthyoplankton, which plays an essential role in the breeding, nursing, and recruitment of freshwater fish species. In this study, different ERL sections were selected to investigate the ichthyoplankton assemblage from the Changjiang River estuary to its Hukou section between May 2018 and August 2020. During the study period, fish larvae of 40, 35, 54, and 46 fish species were sampled in the Rugao (RG), Nanjing (NJ) (nearby estuary), Anqing (AQ), and Hukou (HK) (connected river–lake) sections in the Changjiang River, respectively. Results on ichthyoplankton surveys revealed fluctuating assemblage patterns in the different river sections; larval fish species composition presented ecological habitat-dependent characteristics, which supported the importance of ERL complex for ichthyoplankton development. Furthermore, the density of fish larvae was negatively correlated with water transparency but positively correlated with water temperature, the daily rate of water level increase, and runoff in the limitative range. A generalized additive model analysis indicated that the hydrological factors significantly affecting larval fish abundance are water temperature, transparency, the daily rate of water level increase, and runoff ( p < 0.05). These results also indicated that river estuaries and river–lake connected complexes are essential for ichthyoplankton recruitment and migration. In combination with the historical record, ichthyoplankton assemblage’s patterns in the Changjiang River lower reaches were preliminarily elucidated, although additional works are needed such as assessing effects on their survival and recruitment.

The Relationship between Environmental Factors and Catch Abundance of Hairtail in the East China Sea Using Empirical Dynamic Modeling - Jinfei Hu; Ping Wang; Hailong Zhang (Fishes, 2021)
The East China Sea population of hairtail (Trichiurus lepturus, also known as T. japonicus) is a commercially important element of Chinese fisheries. Hairtail has long been widely exploited. Due to overfishing, however, its production declined over the years. One of solutions to this dilemma is to institute reasonable fishery policies. Generally, skillful short-term and long-term prediction of fish catch is a central tool for guiding the development of fishery policy. Accurate predictions require a comprehensive understanding of the relationship between fluctuations in fish catch and variability in both fishing effort and marine environmental conditions. To investigate the combined impact of fishing effort and marine environments on hairtail catch and to develop models to predict hairtail catch, we applied empirical dynamic modeling (EDM) to data on East China Sea fisheries, including hairtail catch, fishing effort, and marine environmental factors. EDM is an equation-free approach that enables the investigation of various complex systems. We constructed all possible multivariate EDM models to investigate the potential mechanisms affecting hairtail catch. Our analysis demonstrates that all key environmental factors (salinity, summer monsoon, sea surface temperature, precipitation, and power dissipation index of tropical cyclones) have an impact on nutrient supply, which we suggest is the central factor influencing hairtail catch. Finally, our comparison of EDM models with parametric models demonstrates that EDM models overwhelmingly outperform parametric models in analysis of these complex interactions.

Antioxidant CPA-type indole alkaloids produced from the deep-sea derived fungus Aspergillus sp. SCSIO 41024 - Wei-Hao Chen; Kun-Long Li; Xiu-Ping Lin; Sheng-Rong Liao; Bin Yang; Xue-Feng Zhou; Jun-Jian Wang; Yong-Hong Liu; Jun-Feng Wang (Natural Product Research, 2021)

Discriminative optimization algorithm with global–local feature for LIDAR point cloud registration - Jia Wang; Ping Wang; Biao Li; Ruigang Fu; Siyi Zhao; Hong Zhang (International Journal of Remote Sensing, 2021)

Identification and molecular mapping of Rps14, a gene conferring broad-spectrum resistance to Phytophthora sojae in soybean - Liyang Chen; Weidong Wang; Jieqing Ping; Joshua C. Fitzgerald; Guohong Cai; Chancelor B. Clark; Rajat Aggarwal; Jianxin Ma (Theoretical and Applied Genetics, 2021)

Novel wing display and divergent agonistic behaviors of two incipient Psolodesmus damselflies - Leocris S. Batucan; Yu-Hsun Hsu; Jak W. Maliszewski; Liang-Jong Wang; Chung-Ping Lin (The Science of Nature, 2021)

Recent advances in tissue stem cells - Xin Fu; Qiang He; Yu Tao; Mengdi Wang; Wei Wang; Yalong Wang; Qing Cissy Yu; Fang Zhang; Xiaoyu Zhang; Ye-Guang Chen; Dong Gao; Ping Hu; et al. (Science China Life Sciences, 2021)

Responses of ecosystem respiration, methane uptake and nitrous oxide emission to drought in a temperate desert steppe - Ping Yue; Xiaoan Zuo; Kaihui Li; Xiangyun Li; Shaokun Wang; Xujun Ma; Hao Qu; Min Chen; Liangxu Liu; Tom Misselbrook; Qiang Yu (Plant and Soil, 2021)

miR-140-3p regulates the osteogenic differentiation ability of bone marrow mesenchymal stem cells by targeting spred2-mediated autophagy - Ping Liu; Yan Zhuang; Binfei Zhang; Hai Huang; Pengfei Wang; Hu Wang; Yuxuan Cong; Shuangwei Qu; Kun Zhang; Xing Wei (Molecular and Cellular Biochemistry, 2021)

Synthesis and evaluation of mycophenolic acid derivatives as potential anti-Toxoplasma gondii agents - Fan-Fan Shang; Mei-Yuan Wang; Jiang-Ping Ai; Qing-Kun Shen; Hong-Yan Guo; Chun-Mei Jin; Fen-Er Chen; Zhe-Shan Quan; Lili Jin; Changhao Zhang (Medicinal Chemistry Research, 2021)

Recurrent high fever with macular papules in an elderly male: a case report - Ying Wang; Ping Geng; Jian Yin; Qin Xiao; Jiali Xiong; Bingyu Ling; Huihui Wang; Jiyang Xu (Immunologic Research, 2021)

Deterioration Characteristics of Pre-flawed Granites Subjected to Freeze-Thaw Cycles and Compression - Chen Qiao; Yu Wang; Yong-jie Tong; He-ping Yang; Chang-hong Li; C. Qiao (Geotechnical and Geological Engineering, 2021)

Correction to: Enhanced adsorption of phosphorus in soil by lanthanum-modified biochar: improving phosphorus retention and storage capacity - Di Zhao; Yuan Luo; Yi-yang Feng; Qiu-ping He; Li-sheng Zhang; Ke-qiang Zhang; Feng Wang (Environmental Science and Pollution Research, 2021)

Enhanced adsorption of phosphorus in soil by lanthanum-modified biochar: improving phosphorus retention and storage capacity - Di Zhao; Yuan Luo; Yi-yang Feng; Qiu-ping He; Li-sheng Zhang; Ke-qiang Zhang; Feng Wang (Environmental Science and Pollution Research, 2021)

Nitrogen contaminants damage on intestinal epithelial tight junctions: a review - Guo-ping Zhao; Jin-wang Li; Fang-wei Yang; Xiao-yu Wang; Fa-zheng Ren; Guo-fang Pang; Yi-xuan Li (Environmental Chemistry Letters, 2021)

FKgrain: A topography-based software tool for grain segmentation and sizing using factorial kriging - Fu-Chun Wu; Chi-Kuei Wang; Hong Ping Lo (Earth Science Informatics, 2021)

Astaxanthin Ameliorates Blood Pressure in Salt-Induced Prehypertensive Rats Through ROS/MAPK/NF-κB Pathways in the Hypothalamic Paraventricular Nucleus - Hong-Li Gao; Xiao-Jing Yu; Yan Zhang; Chen-Long Wang; Yi-Ming Lei; Jia-Yue Yu; Dong-Miao Zong; Kai-Li Liu; Dong-Dong Zhang; Ying Li; Hua Tian; Nian-Ping Zhang; et al. (Cardiovascular Toxicology, 2021)

Review of chemical stabilizing agents for improving the physical and mechanical properties of loess - Yifei Hou; Ping Li; Jiading Wang (Bulletin of Engineering Geology and the Environment, 2021)

Protective Effect of Vitamin E on Cadmium-Induced Renal Oxidative Damage and Apoptosis in Rats - Jing Fang; Shenglan Xie; Zhuo Chen; Fengyuan Wang; Kejie Chen; Zhicai Zuo; Hengmin Cui; Hongrui Guo; Ping Ouyang; Zhengli Chen; Chao Huang; Wentao Liu; et al. (Biological Trace Element Research, 2021)

Microbial reduction of Cr(VI) in the presence of Ni, Cu and Zn by bacterial consortium enriched from an electroplating contaminated site - Wen-Jing Gong; Xing-Run Wang; He-Ping Zhao (Biodegradation, 2021)

Triaxial mechanical properties and micro mechanism of fiber-modified cement soil - Yang Yao; Na Li; Haibo Kang; Wenjie Yu; Chen Zhang; Ping Jiang; Wei Wang (Arabian Journal of Geosciences, 2021)

Synergistic inhibitory effect of berberine and icotinib on non-small cell lung cancer cells via inducing autophagic cell death and apoptosis - Ping Chen; Chun-Hua Dai; Zhi-Hao Shi; Yi Wang; Jian-Nong Wu; Kang Chen; Jin-Yu Su; Jian Li (Apoptosis, 2021)

Stress response mechanisms and description of three novel species Shewanella avicenniae sp. nov., Shewanella sedimentimangrovi sp. nov. and Shewanella yunxiaonensis sp. nov., isolated from mangrove ecosystem - Guo-Hong Liu; Qi Zhang; Manik Prabhu Narsing Rao; Shang Yang; Rong Tang; Huai Shi; Jie-Ping Wang; Guan-Min Huang; Bo Liu; Shun-Gui Zhou; Wen-Jun Li (Antonie van Leeuwenhoek, 2021)

Distribution of functional microorganisms and its significance for iron, sulphur, and nitrogen cycles in reservoir sediments - Shuang Bai; Meilin Yang; Zheng Chen; Ming Yang; Jing Ma; Xue-Ping Chen; Fushun Wang (Acta Geochimica, 2021)

Effect of typhoon‐induced intertidal‐flat erosion on dominant macrobenthic species ( Meretrix meretrix ) - Benwei Shi; Shi Lun Yang; Stijn Temmerman; Tjeerd Bouma; Tom Ysebaert; Sikai Wang; Yingxin Zhang; Jihua Wu; Haifei Yang; Longhui Zhang; Liqin Zuo; Ya Ping Wang (Limnology and Oceanography, 2021)
Benthic animal populations inhabiting intertidal flats provide important ecosystem functions and services that may be disrupted by physical disturbances such as tropical cyclones, which are predicted to increase in frequency and intensity under future climate change. However, the spatial reach at which tropical cyclones impact macrobenthos populations in intertidal flats remains poorly understood. We examined whether a typhoon with a center that remained more than 1400 km away from the study site could trigger severe erosion of intertidal flats and adversely affect macrobenthos populations. We undertook simultaneous measurements of hydrodynamics (waves, currents), morphodynamics (erosion, accretion) and density and biomass of the macrobenthic bivalve Meretrix meretrix during the passage of this typhoon, on an intertidal flat on the Chinese coast. Our results showed that, in spite of the considerable distance from the storm center, the bed shear stress greatly exceeded the critical value for erosion, resulting in rapid erosion of approximately 10 cm and a nearly 50% reduction in both the density and the biomass of the clam species. Our findings suggest that if storms become more frequent and more intense in a future warmer climate, they may increase physical disturbances to intertidal flats and their benthic animal populations, even at great distances from storm centers.

Anticancer activity of oleiferoside B involving autophagy and apoptosis through increasing ROS release in MCF-7 cells and SMMC-7721 cells - Suxiang Feng; Zhengxia Zha; Zhe Wang; Ping Yang; Jiangping Wu; Xia Li; Qiongming Xu; Yanli Liu (Natural Product Research, 2021)

The Innate Immune Response to Infection by Polyascus gregaria in the Male Chinese Mitten Crab (Eriocheir sinensis), Revealed by Proteomic Analysis - Yanping Yang; Fengjiao Ma; Juanjuan Dong; Lianxing Li; Ping Ren; Yuning Zhang; Yatao Wu; Yinping Wang; Kai Liu; Fang Zhang (Fishes, 2021)
The Chinese mitten crab (Eriocheir sinensis) is a representative catadromous invertebrate of the Yangtze River and a commercial species widely cultivated in China. Both cultivated and wild crabs suffer from a variety of parasites and pathogens, which can result in catastrophic economic losses in aquaculture revenue. Polyascus gregaria, a parasitic barnacle with a highly derived morphology, is specialized in invading these crabs. This study examines the immunological mechanism in E. sinensis infected with P. gregaria. Tandem mass tags (TMT), a specialized method of mass-spectrometry, was used to analyze the infection by P. gregaria resistance at the protein level. In the hepatopancreas of infected crabs, 598 proteins differentially expressed relating to physiological change, of which, 352 were upregulated and 246 were downregulated. Based on this differential protein expression, 104 GO terms and 13 KEGG pathways were significantly enriched. Differentially expressed proteins, such as ATG, cathepsin, serpin, iron-related protein, Rab family, integrin, and lectin, are associated with the lysosome GO term and the autophagy-animal KEGG pathways, both of which likely relate to the immune response to the parasitic P. gregaria infection. These results show the benefit of taking a detailed, protein-level approach to understanding the innate immune response of aquatic invertebrates to macroparasite infection.

Cytotoxic triterpenoid glycosides from leaves of Cyclocarya paliurus - Hui-Hui Sun; Wen-Yan Lv; Jie Tan; Yu-Cheng Tang; Hui Zhu; Jian-Bo Qu; Jing Li; Jian-Ping Wu; Xi-Wen Chang; Zhi-Chun Yang; Wen-Xuan Wang; Zu-Hui Chen; et al. (Natural Product Research, 2021)

One new α , β -unsaturated 7-ketone sterol from the mangrove-derived fungus Phomopsis sp.MGF222 - Xiao-Chen Zhu; Guo-Lei Huang; Rong-Qing Mei; Bin Wang; Xue-Ping Sun; You-Ping Luo; Jing Xu; Cai-Juan Zheng (Natural Product Research, 2021)

A new phenol derivative isolated from mangrove-derived fungus Eupenicillium sp. HJ002 - Rong-Qing Mei; Xu-Hua Nong; Bin Wang; Xue-Ping Sun; Guo-Lei Huang; You-Ping Luo; Cai-Juan Zheng; Guang-Ying Chen (Natural Product Research, 2021)

A cytochrome P450 CYP81AM1 from Tripterygium wilfordii catalyses the C-15 hydroxylation of dehydroabietic acid - Jiadian Wang; Ping Su; Linhui Gao; Yifeng Zhang; Jian Wang; Lichan Tu; Yujun Zhao; Yun Lu; Yan Yin; Luqi Huang; Wei Gao (Planta, 2021)

Genetic Prion Disease: Insight from the Features and Experience of China National Surveillance for Creutzfeldt-Jakob Disease - Qi Shi; Cao Chen; Kang Xiao; Wei Zhou; Li-Ping Gao; Dong-Dong Chen; Yue-Zhang Wu; Yuan Wang; Chao Hu; Chen Gao; Xiao-Ping Dong (Neuroscience Bulletin, 2021)

Developments in Biological Mechanisms and Treatments for Negative Symptoms and Cognitive Dysfunction of Schizophrenia - Qiongqiong Wu; Xiaoyi Wang; Ying Wang; Yu-Jun Long; Jing-Ping Zhao; Ren-Rong Wu (Neuroscience Bulletin, 2021)
The causal mechanisms and treatment for the negative symptoms and cognitive dysfunction in schizophrenia are the main issues attracting the attention of psychiatrists over the last decade. The first part of this review summarizes the pathogenesis of schizophrenia, especially the negative symptoms and cognitive dysfunction from the perspectives of genetics and epigenetics. The second part describes the novel medications and several advanced physical therapies (e.g., transcranial magnetic stimulation and transcranial direct current stimulation) for the negative symptoms and cognitive dysfunction that will optimize the therapeutic strategy for patients with schizophrenia in future.

Analysis of Dangchuan 5# landslide on January 27, 2021, in Yongjing County, Gansu Province, China - Wenbin Chang; Aiguo Xing; Ping Wang; Yu Zhuang; Kaiping Jin; Junyi He; Shaofeng Chai (Landslides, 2021)

Geo-structures and deformation-failure characteristics of rockslide areas near the Baige landslide scar in the Jinsha River tectonic suture zone - Shi-lin Zhang; Yue-ping Yin; Xie-wen Hu; Wen-pei Wang; Zong-liang Li; Xin-ming Wu; Gang Luo; Sai-nan Zhu (Landslides, 2021)

Differences in pathogenicity and physiologic races between Pyricularia oryzae isolates from indica and japonica rice varieties - Zhong-na Hao; Zhen Zhang; Hai-ping Qiu; Rong-yao Chai; Shi-zhen Wang; Yan-li Wang; Jiao-yu Wang; Guo-chang Sun (Journal of Plant Pathology, 2021)

Distinct root system acclimation patterns of seagrass Zostera japonica in sediments of different trophic status: a research by X-ray computed tomography - Xiaoyue Song; Yi Zhou; Jiangning Zeng; Lu Shou; Xiaomei Zhang; Shidong Yue; Wei Gao; Weihua Feng; Zhifu Wang; Ping Du (Journal of Oceanology and Limnology, 2021)

Inhibition of miR-129 Improves Neuronal Pyroptosis and Cognitive Impairment Through IGF-1/GSK3β Signaling Pathway: An In Vitro and In Vivo Study - Feng Wang; Lu Wang; Guanghong Sui; Caixia Yang; Mengtian Guo; Xiangyang Xiong; Zheng Chen; Qiang Zhang; Ping Lei (Journal of Molecular Neuroscience, 2021)

Association between ambient air pollution and multiple sclerosis: a systemic review and meta-analysis - Chao Tang; Qing-Ru Li; Yan-Mei Mao; Yuan-Rui Xia; Heng-Sheng Guo; Jun-Ping Wang; Zong-Wen Shuai; Dong-Qing Ye (Environmental Science and Pollution Research, 2021)

Effects of Low‐dose Mercury Exposure in Newborns on mRNA Expression Profiles - Haohao Liu; Chanchan Zhang; Fuli Wen; Lin Feng; Huiqun Wang; Wenjuan Wang; Ping Li (Bulletin of Environmental Contamination and Toxicology, 2021)

Reduced Serum Zinc Ion Concentration Is Associated with Coronary Heart Disease - Heyu Meng; Yueying Wang; Fengfeng Zhou; Jianjun Ruan; Meiyu Duan; Xue Wang; Qiong Yu; Ping Yang; Weiwei Chen; Fanbo Meng (Biological Trace Element Research, 2021)

Hydrological characteristics and changes in the Nu-Salween River basin revealed with model-based reconstructed data - Fan Yang; Hui Lu; Kun Yang; Guang-wei Huang; Yi-shan Li; Wei Wang; Ping Lu; Fu-qiang Tian; Yu-gang Huang (Journal of Mountain Science, 2021)

Surface acoustic wave (SAW) techniques in tissue engineering - Deming Jiang; Jingwen Liu; Yuxiang Pan; Liujing Zhuang; Ping Wang (Cell and Tissue Research, 2021)

Molecular characterization of two dsRNAs that could correspond to the genome of a new mycovirus that infects the entomopathogenic fungus Beauveria bassiana - Najie Shi; Fei Hu; Ping Wang; Yuxiang Zhang; Qiuyan Zhu; Guogen Yang; Bo Huang (Archives of Virology, 2021)

Qaidamihabitans albus gen. nov., sp. nov., a new member of the family Pseudonocardiaceae, and transfer of Prauserella shujinwangii to Qaidamihabitans gen. nov. as Qaidamihabitans shujinwangii comb. nov. - Li-Sha Tian; Gang-Qiang Jiang; Rui Li; Ping Ni; Chuan-En Li; Hong-Yan Zhang; Juan Wang; Xiao-Ping Zhang; Yun Wang; Shu-Kun Tang (Archives of Microbiology, 2021)

Effects of Low Temperature on Shrimp and Crab Physiology, Behavior, and Growth: A Review - Xianyun Ren; Qiong Wang; Huixin Shao; Yao Xu; Ping Liu; Jian Li (Frontiers in Marine Science, 2021)
As important aquaculture species worldwide, shrimps and crabs are thermophilic animals with a feeble thermoregulation ability. Changes in environmental factors are the main reason for the decrease in the immunity and disease resistance ability of cultured organisms. Water temperature is one of the most common abiotic stress factors for aquatic ectotherms. It influences nearly all biochemical and physiological processes in crustaceans, resulting in an imbalance in ion and water homeostasis, neuromuscular function loss, cellular dehydration, and altered metabolic pathways. The present review summarizes the current knowledge on the effects of low temperature on the physiological response, and the behavior, development, and growth of shrimp and crab. We suggest a deeper research to understand the physiological processes involved in thermoregulation; this knowledge could be used to reduce the adverse effects in the shrimps and crabs during the culture.

Comparative Transcriptomic and Proteomic Analysis of Exopalaemon carinicauda in Response to Alkalinity Stress - Zhen Qin; Qianqian Ge; Jiajia Wang; Mingdong Li; Ping Liu; Jian Li; Jitao Li (Frontiers in Marine Science, 2021)
Saline-alkaline waters are stressful environments where most aquatic animals can’t survive normally, and alkalinity is one of the key limited environmental factors. Due to strong adaptability to environment, the ridgetail white prawn Exopalaemon carinicauda is a potential good species suitable for large-scale culture in saline-alkaline waters. Exploring its alkaline adaptability mechanism will help to guide more marine crustaceans to saline-alkaline culture. In this study, an integrative analysis of the gill-specific transcriptome and proteome at 0, 12, and 36 h after alkalinity stress was performed to identify important regulators and pathways involved in alkalinity adaption of E. carinicauda . A total of 3,157 differentially expressed genes (DEGs) and 443 differentially expressed proteins (DEPs) were identified at 12 and 36 h compared with 0 h. Base on the transcriptome analysis, the Gene Ontology (GO) enriched terms were mainly related to ion transport, including “calcium-transporting ATPase activity,” “ATPase coupled ion transmembrane transporter activity,” “divalent inorganic cation transmembrane transporter activity,” etc., and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways mainly refer to the processes of endocrine system at both 12, and 36 h. Based on the proteomic analysis, KEGG pathways related to lipolysis and amino acids metabolism were significantly enriched at 12 h, and carbohydrate metabolism and immune response were significantly enriched at 36 h. There were significantly up-regulated expressions of ion transport related genes including aquaporin, carbonic anhydrase, ammonium transporter Rh type A-like, Na + /H + -exchanger, etc., as well as ion transport proteins including V-type proton ATPase 116 kDa subunit a-like isoform X1, sodium-potassium ATPase beta, vesicle associated membrane protein, etc. after alkalinity exposure, which indicating their important roles in response to alkalinity stress. The results of integrated analysis between proteome and transcriptome showed that up-regulated DEG/DEP (aldehyde dehydrogenase) was significantly enriched at 12 h and the up-regulated DEG/DEP (peptidylglycine alpha) was significantly enriched at 36 h, suggesting the two molecules may be critical in response to alkalinity change. This study reveals the first time-course, gill-specific, combined transcriptomic and proteomic profiling associated with alkalinity adaption of E. carinicauda and provides new insights into the mechanisms underlying the molecular response to alkalinity stress in shrimp.

Liquid–Solid Flow Characteristics in Vertical Swirling Hydraulic Transportation with Tangential Jet Inlet - Jiyang Qi; Jie Yin; Fei Yan; Ping Liu; Tieli Wang; Chen Chen (Journal of Marine Science and Engineering, 2021)
In order to improve the efficiency and safety of vertical hydraulic transport systems for non-spherical particles, a new pipeline transport system with a tangential jet inlet is adopted in this study, and a modified non-spherical drag coefficient model is used to analyze the liquid–solid flow characteristics based on the CFD-DEM (Computational Fluid Dynamics-Discrete Element Method) coupling method. The focus of the study is on the influence of different tangential flow proportions in terms of the velocity distribution, the vorticity, the total pressure, the concentration and drag force of particles of various shapes. The conveying efficiency is measured according to the fluid velocity distribution and the particle concentration, and the safety of conveying is evaluated according to the flow structure and drag force of the particles. The result shows that the velocity of the swirling pipes is significantly higher than the straight pipe. With the increase of the tangential flow proportion, the swirling number and the vorticity magnitude increase, and the vortex core is broken and merged more quickly. Furthermore, the concentration gap and axial drag force gap between particles of various shapes are reduced with the effect of swirling flow, the particle concentration increases, and the particles of each component are uniformly mixed and transported.

Pleosporalins H and I, two new heptaketides from the endophytic fungus Pleosporales sp. F46 by using OSMAC strategy - Hong-Xia Yang; Xiao-Ping Peng; Han Gao; Hui-Min Zhang; Zi-Ru Wang; Gang Li; Hong-Xiang Lou (Natural Product Research, 2021)

Single-cell transcriptomes of peripheral blood cells indicate and elucidate severity of COVID-19 - Xiaowei Xie; Xuelian Cheng; Gaoxiang Wang; Biao Zhang; Mengyao Liu; Liting Chen; Hui Cheng; Sha Hao; Jianfeng Zhou; Ping Zhu; Tao Cheng (Science China Life Sciences, 2021)

Responses of leaf litter decomposability to nitrogen and phosphorus additions are associated with cell wall carbohydrate composition in a subtropical plantation - Xiang-Min Fang; Xiu-Lan Zhang; Ying-Ying Zong; Wen-Qing Li; Jian-Jun Li; Li-Ping Guo; Huimin Wang; Fu-Sheng Chen (Plant and Soil, 2021)

ASIC2 Synergizes with TRPV1 in the Mechano-Electrical Transduction of Arterial Baroreceptors - Xiaodong Yan; Sitao Zhang; Haiyan Zhao; Ping Liu; Haixia Huang; Weizhen Niu; Wei Wang; Chen Zhang (Neuroscience Bulletin, 2021)

Long non-coding RNA Gm11974 aggravates oxygen–glucose deprivation-induced injury via miR-122-5p/SEMA3A axis in ischaemic stroke - Ling Yang; Lijuan Wang; Juan Wang; Ping Liu (Metabolic Brain Disease, 2021)

Uniconazole, 6-Benzyladenine, and Diethyl Aminoethyl Hexanoate Increase the Yield of Soybean by Improving the Photosynthetic Efficiency and Increasing Grain Filling in Maize–Soybean Relay Strip Intercropping System - Kai Luo; Chen Xie; Jin Wang; Qing Du; Ping Cheng; Tian Wang; Yongcheng Wu; Wenyu Yang; Taiwen Yong (Journal of Plant Growth Regulation, 2021)

The interplay of DAMPs, TLR4, and proinflammatory cytokines in pulmonary fibrosis - Siavash Bolourani; Max Brenner; Ping Wang (Journal of Molecular Medicine, 2021)
Pulmonary fibrosis is a chronic debilitating condition characterized by progressive deposition of connective tissue, leading to a steady restriction of lung elasticity, a decline in lung function, and a median survival of 4.5 years. The leading causes of pulmonary fibrosis are inhalation of foreign particles (such as silicosis and pneumoconiosis), infections (such as post COVID-19), autoimmune diseases (such as systemic autoimmune diseases of the connective tissue), and idiopathic pulmonary fibrosis. The therapeutics currently available for pulmonary fibrosis only modestly slow the progression of the disease. This review is centered on the interplay of damage-associated molecular pattern (DAMP) molecules, Toll-like receptor 4 (TLR4), and inflammatory cytokines (such as TNF-α, IL-1β, and IL-17) as they contribute to the pathogenesis of pulmonary fibrosis, and the possible avenues to develop effective therapeutics that disrupt this interplay.

MiR-590-5p inhibits pathological hypertrophy mediated heart failure by targeting RTN4 - Ping Fan; Likun Zhang; Tianyu Cheng; Jing Wang; Junyun Zhou; Li Zhao; Cuie Hua; Quan Xia (Journal of Molecular Histology, 2021)

Emerging role of air pollution in chronic kidney disease - Yue Chen; Fan Cao; Jian-Ping Xiao; Xin-Yu Fang; Xue-Rong Wang; Li-Hong Ding; De-Guang Wang; Hai-Feng Pan (Environmental Science and Pollution Research, 2021)

Innovation’s Spillover Effect in China: Incorporating the Role of Environmental Regulation - Yue Wang; Fuqin Zhang; Mingbo Zheng; Chun-Ping Chang (Environmental Modeling & Assessment, 2021)

Diversity and arsenic-metabolizing gene clusters of indigenous arsenate-reducing bacteria in high arsenic groundwater of the Hetao Plain, Inner Mongolia - Yanhong Wang; Dazhun Wei; Ping Li; Zhou Jiang; Han Liu; Chun Qing; Helin Wang (Ecotoxicology, 2021)

Damage mechanism of tunnels in the high-content salt rock stratum - Ping Zhou; Jinyi Li; Yifan Jiang; Feicong Zhou; Ming Lin; Jiayong Lin; Zhijie Wang (Bulletin of Engineering Geology and the Environment, 2021)

Stable isotopes (δ2H) in feathers identify non-breeding origins of the endangered Jankowski’s Bunting - Zheng Han; Hai-Tao Wang; Kevin J. Kardynal; Keith A. Hobson; Wei-Ping Shang; li-shi Zhang; Yun-lei Jiang; Frédéric Jiguet (Journal of Ornithology, 2021)

Does polar amplification exist in Antarctic surface during the recent four decades? - Shi-meng Wang; Ai-hong Xie; Jiang-ping Zhu (Journal of Mountain Science, 2021)

Deep profile soil moisture distribution characteristics for different micro-topographies on the semi-arid Loess Plateau, China - Qing-ping Gou; Qing-ke Zhu; Yi-xuan Li; Xiang-lei Tian; Peng-xiang Wang; Yun-ling Xin; Shu-yuan Luo (Journal of Mountain Science, 2021)

A Novel Fusion Forecast Model for Hail Weather in Plateau Areas Based on Machine Learning - Yan Zhang; Zhong Ji; Bing Xue; Ping Wang (Journal of Meteorological Research, 2021)

Impacts of human interventions on the seasonal and nodal dynamics of the M2 and K1 tidal constituents in Lingdingyang Bay of the Zhujiang River Delta, China - Ping Zhang; Qingshu Yang; Haidong Pan; Heng Wang; Meifang Xie; Huayang Cai; Nanyang Chu; Liangwen Jia (Acta Oceanologica Sinica, 2021)

A Modified Approach of Extracting Landfast Ice Edge Based on Sentinel-1A InSAR Coherence Image in the Gulf of Bothnia - Zhiyong Wang; Zihao Wang; Hao Li; Ping Ni; Jian Liu (Journal of Marine Science and Engineering, 2021)
Landfast ice is an integral component of the coastal ecosystem. Extracting the edge and mapping the extent of landfast ice are one of the main methods for studying ice changes. In this work, a standardized process for extracting landfast ice edge in the Baltic Sea using the InSAR coherence image is established with Sentinel-1 radar data and InSAR technology. A modified approach combining multiscale segmentation and morphological erosion is then proposed to provide a reliable way to extract landfast ice edge. Firstly, the coherence image is obtained using InSAR technology. Then, the edge is separated and extracted with the modified approach. The modified approach is essentially a four-step procedure involving image segmentation, median filter, morphological erosion, and rejection of small patches. Finally, the full extent of landfast ice can be obtained using floodfill algorithm. Multiple InSAR image pairs of Sentinel-1A acquired from 2018 to 2019 are utilized to successfully extract the landfast ice edge in the Gulf of Bothnia. The results show that the landfast ice edge and the extents obtained by the proposed approach are visually consistent with those shown in the ice chart issued by the Swedish Meteorological and Hydrological Institute (SMHI) over a coastline length of 345 km. The mean distance between land–water boundary and the coastline issued by the National Oceanic and Atmospheric Administration (NOAA) is 109.1 m. The modified approach obviously preserves more details in local edge than the reference method. The experimental results show that the modified approach proposed in this paper can extract the edge and map the extent of landfast ice more accurately and quickly, and is therefore expected to contribute to the further understanding and analyzing the changes of landfast ice in the future.

Characterization of a novel shrimp pathogen, Vibrio brasiliensis , isolated from Pacific white shrimp, Penaeus vannamei - Ge Li; Guosi Xie; Hailiang Wang; Xiaoyuan Wan; Xinshu Li; Chengyin Shi; Ziyan Wang; Miao Gong; Ting Li; Ping Wang; Qingli Zhang; Jie Huang (Journal of Fish Diseases, 2021)
A novel pathogenic strain Vibrio 20190611023 was isolated from the hepatopancreas of moribund cultured Penaeus vannamei suffering from black gill disease. This strain was identified as V . brasiliensis based on the phylogenetic analyses of 16S rDNA gene and five other housekeeping genes (i.e., gapA , ftsZ , mreB , topA and gyrB ). Some biochemical features of this strain were determined with an API 20NE system, and its haemolytic activity was determined using a sheep blood agar plate. The pathogenicity of this isolate 20190611023 was confirmed by the experimental challenge tests and histopathological examinations. P. vannamei were challenged via reverse gavage with different doses of bacterial suspensions. The calculated median lethal dose (LD 50 ) was (3.16 ± 1.78) × 10 5 CFU/g (body weight). Moreover, antibiotic susceptibility tests were performed, the results of which showed that the strain 20190611023 was sensitive to chloramphenicol, compound sulphamethoxazole, ciprofloxacin, doxycycline and oxacillin, but resistant to erythromycin, kanamycin, gentamicin, cefoperazone, ceftriaxone, cefamezin and piperacillin. To our knowledge, this is the first report for demonstrating V . brasiliensis as a shrimp pathogen, which expands the host range of V . brasiliensis infection. The present study highlights that more attention should be paid to this novel pathogen in intensive shrimp aquaculture.

Anti-inflammatory steroids from the fruits of Artocarpus heterophyllus - Yun-Yao Liu; Ting Wang; Rong-Xiang Yang; Hao-Xuan Tang; Lei Qiang; Yan-Ping Liu (Natural Product Research, 2021)

Variable Effects on Benthic Community From Diking to Eradicate Invasive Plants in the Yangtze Estuary Salt Marsh - Sikai Wang; Qiang Sheng; Feng Zhao; Tingting Zhang; Ping Zhuang (Frontiers in Marine Science, 2021)
The removal of invasive plants is a global concern, and ecological restoration methods have been a major research topic in recent years. In the estuarine salt marsh of the Yangtze River, dikes are typically used in ecological restoration projects to eradicate the invasive plant Spartina alterniflora . We explored ways of optimizing dike construction and of providing an effective basis for the wetland ecological control and protection of biodiversity and analyzed the effects on the macrobenthos of fully and partially dikes. The measurement of the quantitative change in macrobenthos diversity and species composition was carried out in the project area and in a control before (2013) and after (2016) dike construction. Results showed that the number of species and average density decreased significantly in the fully diked enclosed area but increased in the partially diked semi-enclosed area. Outside the project area, all site samples showed increased species richness and average density after dike construction. This study indicated that macrobenthos was negatively affected by the dike project in the inside diked area. However, when the tidewater canals were preserved to maintain the connection between the inside and outside areas, there was a positive effect on macrobenthos in the project area. We suggest that canals are preserved while diking in the salt marsh and that gates are opened regularly to maintain the water and nutrient connectedness inside and outside the dike. The diking project mostly affected mollusks and polychaetes, which are the indispensable food sources for birds and fish. The study provides valid evidence for the management of estuarine salt marsh and the protection of macrobenthos.

Detoxification of aflatoxin B 1 in broiler chickens by a triple-action feed additive - Hongwei Guo; Juan Chang; Ping Wang; Qingqiang Yin; Chaoqi Liu; Silu Li; Qun Zhu; Mingfan Yang; Xiaofei Hu (Food Additives & Contaminants: Part A, 2021)

Vine copula and cloud model-based programming approach for agricultural water allocation under uncertainty - Baoying Shan; Shanshan Guo; Youzhi Wang; Hao Li; Ping Guo (Stochastic Environmental Research and Risk Assessment, 2021)

A model integrating the system dynamic model with the risk based two-stage stochastic robust programming model for agricultural-ecological water resources management - Wang Youzhi; Fernald Alexander; Guo Ping (Stochastic Environmental Research and Risk Assessment, 2021)

On the origin of SARS-CoV-2—The blind watchmaker argument - Chung-I Wu; Haijun Wen; Jian Lu; Xiao-dong Su; Alice C. Hughes; Weiwei Zhai; Chen Chen; Hua Chen; Mingkun Li; Shuhui Song; Zhaohui Qian; Qihui Wang; et al. (Science China Life Sciences, 2021)

HDAC inhibitors improve CRISPR-mediated HDR editing efficiency in iPSCs - Jian-Ping Zhang; Zhi-Xue Yang; Feng Zhang; Ya-Wen Fu; Xin-Yue Dai; Wei Wen; Beldon Zhang; Hannah Choi; Wanqiu Chen; Meredith Brown; David Baylink; Lei Zhang; et al. (Science China Life Sciences, 2021)

Problem-solving deficits in methcathinone use disorder - Hang-Bin Zhang; Di Zhao; Yu-Ping Liu; Li-Xun Wang; Bo Yang; Ti-Fei Yuan (Psychopharmacology, 2021)

The Extraction and Analysis of Deformation Features of Hualien Earthquake Based on Sentinel-1A/B SAR Data - Jin Wang; Ping Han; Guangxue Li (Journal of the Indian Society of Remote Sensing, 2021)

Both carbon sequestration and yield are related to particulate organic carbon stability affected by organic amendment origins in mollisol - Xiaojing Qu; Xiaohan Wang; Jinggui Wu; Ping He (Journal of Soils and Sediments, 2021)

Evaluating marginal genetic correlation of associated loci for complex diseases and traits between European and East Asian populations - Haojie Lu; Ting Wang; Jinhui Zhang; Shuo Zhang; Shuiping Huang; Ping Zeng (Human Genetics, 2021)

Removal of SO2 from smelting flue gas by using copper tailings with MnSO4: factors optimization by response surface methodology - Lei Tao; Langlang Wang; Yangjie Zhou; Ningmeng Hu; Jun Cai; Xiaoyu Chen; Xueqian Wang; Ping Ning (Environmental Science and Pollution Research, 2021)

A comparative study of peroxydisulfate and peroxymonosulfate activation by a transition metal–H2O2 system - Yanli Zhu; Yuan Liu; Ping Li; Yue Zhang; Gang Wang; Youxian Zhang (Environmental Science and Pollution Research, 2021)

Insights from comparative proteomic analysis into degradation of phenanthrene and salt tolerance by the halophilic Martelella strain AD-3 - Xin Chen; Weiwei Wang; Haiyang Hu; Hongzhi Tang; Yongdi Liu; Ping Xu; Kuangfei Lin; Changzheng Cui (Ecotoxicology, 2021)

Two new selenite reducing bacterial isolates from paddy soil and the potential Se biofortification of paddy rice - Chunlei Huang; Helin Wang; Xinyan Shi; Yanhong Wang; Ping Li; Hanqin Yin; Yixian Shao (Ecotoxicology, 2021)

Methane Concentration in the Heartwood of Living Trees and Estimated Methane Emission on Stems in Upland Forests - Zhi-Ping Wang; Huan-Long Li; Hong-Hui Wu; Shi-Jie Han; Jian-Hui Huang; Xi-Mei Zhang; Xing-Guo Han (Ecosystems, 2021)

Puerarin reduces impairment of intestinal and adipose immune responses to influenza virus infection in mice - Mao-Seng Zeng; Wen-Di Yu; Hui-Xian Wang; Pei-Ping Xu; Jin-Yuan Liu (Archives of Virology, 2021)

Biological prevention and control of pitaya fruit canker disease using endophytic fungi isolated from papaya - Furun Wang; Ruining Zhang; Zhouyu Yuan; Ping Chen (Archives of Microbiology, 2021)

Spatiotemporal characteristics and trend assessment of Ms ≥ 5.6 earthquakes in the Tianshan area of China based on co-occurrence analysis and commensurability - Jia Wan; Jun-Ping Yan; Zi-Qiang Liu; Xiao-Meng Wang; Yu-Feng Zhang; Cheng-Bo Wang (Applied Geophysics, 2021)

An Exact Algorithm for Task Allocation of Multiple Unmanned Surface Vehicles with Minimum Task Time - Kai Xue; Zhiqin Huang; Ping Wang; Zeyu Xu (Journal of Marine Science and Engineering, 2021)
Task allocation of unmanned surface vehicles (USVs) with low task cost is an important research area which assigns USVs from starting points to different target points to complete tasks. Most of the research lines of task allocation are using heuristic algorithms to obtain suboptimal solutions to reduce both the max task cost and total task cost. In practice, reducing the maximum is more important to task time, which is from the departure of USVs to the last USV arriving at the designated position. In this paper, an exact algorithm is proposed to minimize the max task time and reduce the total task time based on the Hungarian algorithm. In this algorithm, task time is composed of the travel time along the planned path and the turning time at initial and target points. The fast marching square method (FMS) is used to plan the travel path with obstacle avoidance. The effectiveness and practicability of the proposed algorithm are verified by comparing it with the Hungarian algorithm (HA), the auction algorithm (AA), the genetic algorithm (GA) and the ant colony optimization algorithm (ACO). The results of path planning and task allocation are displayed in the simulation.

Modulation of Antioxidant Enzymes, Heat Shock Protein, and Intestinal Microbiota of Large Yellow Croaker (Larimichthys crocea) Under Acute Cold Stress - Huirong Lv; Yanli Liu; Haidong Li; Xiaolong Yin; Ping Wang; Xiaoyu Qu; Yang Gao; Weiye Li; Zhangjie Chu (Frontiers in Marine Science, 2021)
The experiment was conducted in a sealed, temperature-controlled room. The initial water temperature of the treatment group was 12°C, lowered by 1°C a day to 8°C using a chiller, and maintained at that temperature for 3 days. The water temperature was then increased by 1°C per day to 12°C using a heater. The control group were the fish that kept at 12°C at the beginning of the experiment; T1 represents the group that sampled on the first day when the water temperature reached 8 from 12°C; T2 represents the group that sampled when the fish had been kept at 8°C for 3 days; T3 represents the group sampled when the water temperature was increased to 12 from 8°C. The antioxidant abilities of the liver, muscle, and intestine of large yellow croaker at different temperatures and times were determined, and the expression of HSP70 and HSP90 in the liver as well as the changes in intestinal microbiota were investigated. The results showed that the activities of SOD, CAT, GSH-Px, and MDA content increased significantly when the water temperature decreased from 12 to 8°C, significantly higher than those in the control group. The gene expression levels of HSP70 and HSP90 in the liver of large yellow croaker significantly increased under low temperature stress and were significantly higher than those in the control group. The diversity and abundance of intestinal microbiota of large yellow croaker were altered when the water temperature was maintained at 8°C, although the change was not obvious. Proteobacteria, Firmicutes, and Bacteroidetes were the dominate phyla in both the 12 and 8°C groups, and the temperature variation did not change the functional pathways of the microbiota. In conclusion, the acute temperature variation affected the antioxidant ability and heat shock protein expression of large yellow croaker but did not affect the diversity or abundance of the intestinal microbiota. These results will provide a theoretical basis for studying the mechanisms of large yellow croaker overwintering and adaptation to low temperatures.

A new p -terphenyl derivative from the fruiting bodies of Sarcodon imbricatus (L.) P. Karst - Feng-Ming Zhang; Yue-Hu Wang; Ping Zhao; Fu-Qiang Yu (Natural Product Research, 2021)

Association of gut microbiomes with lung and esophageal cancer: a pilot study - Weitao Shen; Derong Tang; Yali Deng; Huilin Li; Tian Wang; Ping Wan; Ran Liu (World Journal of Microbiology and Biotechnology, 2021)

A bean common mosaic virus-resistance gene in the soybean variant V94-5152 was mapped to the Rsv4 locus conferring resistance to soybean mosaic virus - Xue-Ting Liu; Xiao-Yi Wu; Wen-Ping Wu; Mian Wu; Jian-Qun Chen; Bin Wang (Theoretical and Applied Genetics, 2021)

Alpha-Lipoic Acid Attenuates Cadmium- and Lead-Induced Neurotoxicity by Inhibiting Both Endoplasmic-Reticulum Stress and Activation of Fas/FasL and Mitochondrial Apoptotic Pathways in Rat Cerebral Cortex - Yan Yuan; Shi Wen Zhao; Shuang Quan Wen; Qiao Ping Zhu; Li Wang; Hui Zou; Jian Hong Gu; Xue Zhong Liu; Jian Chun Bian; Zong Ping Liu (Neurotoxicity Research, 2021)

Drought disaster risk management based on optimal allocation of water resources - Xiao Liu; Ping Guo; Qian Tan; Fan Zhang; Yan Huang; Youzhi Wang (Natural Hazards, 2021)

DJ-1 activates the noncanonical NF-κB pathway via interaction with Cezanne to inhibit the apoptosis and promote the proliferation of Ishikawa cells - Qi-Zhou Zhu; Hao-Yue Liu; Xiao-Yan Zhao; Le-Jia Qiu; Ting-Ting Zhou; Xue-Ying Wang; He-Ping Chen; Zhong-Qing Xiao (Molecular Biology Reports, 2021)

Extracellular CIRP Activates the IL-6Rα/STAT3/Cdk5 Pathway in Neurons - Archna Sharma; Max Brenner; Asha Jacob; Philippe Marambaud; Ping Wang (Molecular Neurobiology, 2021)

LncRNA MYCNOS promotes glioblastoma cell proliferation by regulating miR-216b/FOXM1 axis - Ping Zhao; Ting Li; Youliang Wang; Yong Wang; Qi Gu; Zhi Li (Metabolic Brain Disease, 2021)

A small attentional YOLO model for landslide detection from satellite remote sensing images - Libo Cheng; Jia Li; Ping Duan; Mingguo Wang (Landslides, 2021)

Overexpression of MdPHR1 Enhanced Tolerance to Phosphorus Deficiency by Increasing MdPAP10 Transcription in Apple (Malus × Domestica) - Rui Li; Jian-Ping An; Chun-Xiang You; Xiao-Fei Wang; Yu-Jin Hao (Journal of Plant Growth Regulation, 2021)

Genetic diversity of potato virus Y potato isolates from Shandong province, China - Meng-Ao Jia; Lu Wang; Ji-Wu Zhang; Yu-Shuang Guo; Xiang-Dong Li; Yan-Ping Tian (Journal of Plant Pathology, 2021)

The Integration of Carbon Price Between European and Chinese Markets: What are the Implications? - Yunpeng Wang; Qiang Fu; Chun-Ping Chang (International Journal of Environmental Research, 2021)

Conversion of rice husk into fermentable sugar and silica using acid-catalyzed ionic liquid pretreatment - YuJie Wang; Jing-yong Liu; Jian Sun; Sumarlin Shangdiar; Kassian T.T. Amesho; Yung-Chang Lin; Yen-Ping Peng; Ken-Lin Chang (Environmental Science and Pollution Research, 2021)

Microbial characteristics response to the soil quality of newly created farmland on the Loess Plateau - Chen Xu; Yi-ping Chen; Cui-cui Su; Ji-fu Ma; Jun-hua Wu; Kai-bo Wang; Yi Wang; Yao Jiang (Environmental Science and Pollution Research, 2021)

Correction to: TIP60 recruits SUV39H1 to chromatin to maintain heterochromatin genome stability and resist hydrogen peroxide-induced cytotoxicity - Bo Tu; Yantao Bao; Ming Tang; Qian Zhu; Xiaopeng Lu; Hui Wang; Tianyun Hou; Ying Zhao; Ping Zhang; Wei-Guo Zhu (Genome Instability & Disease, 2021)

Effect on simultaneous removal of ammonia, nitrate, and phosphorus via advanced stacked assembly biological filter for rural domestic sewage treatment - Ziyun Fan; Zhiwei Liang; Ancheng Luo; Yunlong Wang; Yuanyuan Ma; Yi Zhao; Xiansheng Lou; Ruijie Jia; Yan Zhang; Shaowei Ping (Biodegradation, 2021)

Assessment of the rock slope stability of Fushun West Open-pit Mine - Fei Zhang; Tianhong Yang; Lianchong Li; Jianqing Bu; Tianliang Wang; Ping Xiao (Arabian Journal of Geosciences, 2021)

Enrichment of marine productivity utilizing steelmaking slag: managing conflicting stakeholders’ interests in Taiwan - Yung-Sheng Chen; Ming-Sheng Ko; Yu-Cheng Wang; Ping Chen; Ta-Kang Liu (Aquaculture International, 2021)

The sub-inhibitory concentration of cinnamaldehyde resists Aeromonas hydrophila pathogenicity via inhibition of W-pili production - Ping Ouyang; Jiehao Chen; Lizi Yin; Yi Geng; Defang Chen; Kaiyu Wang; Weiming Lai; Hongrui Guo; Jing Fang; Zhengli Chen; Li Tang; Chao Huang; et al. (Aquaculture International, 2021)

Long‐term nitrogen input alters plant and soil bacterial, but not fungal beta diversity in a semiarid grassland - Weixing Liu; Lingli Liu; Xian Yang; Meifeng Deng; Zhou Wang; Pandeng Wang; Sen Yang; Ping Li; Ziyang Peng; Lu Yang; Lin Jiang (Global Change Biology, 2021)
Anthropogenic nitrogen (N) input is known to alter plant and microbial α‐diversity, but how N enrichment influences β‐diversity of plant and microbial communities remains poorly understood. Using a long‐term multilevel N addition experiment in a temperate steppe, we show that plant, soil bacterial and fungal communities exhibited different responses in their β‐diversity to N input. Plant β‐diversity decreased linearly as N addition increased, as a result of increased directional environmental filtering, where soil environmental properties largely explained variation in plant β‐diversity. Soil bacterial β‐diversity first increased then decreased with increasing N input, which was best explained by corresponding changes in soil environmental heterogeneity. Soil fungal β‐diversity, however, remained largely unchanged across the N gradient, with plant β‐diversity, soil environmental properties, and heterogeneity together explaining an insignificant fraction of variation in fungal β‐diversity, reflecting the importance of stochastic community assembly. Our study demonstrates the divergent effect of N enrichment on the assembly of plant, soil bacterial and fungal communities, emphasizing the need to examine closely associated fundamental components (i.e., plants and microorganisms) of ecosystems to gain a more complete understanding of ecological consequences of anthropogenic N enrichment.

Genetic mapping of highly versatile and solvent‐tolerant Pseudomonas putida B6 ‐2 ( ATCC BAA ‐2545) as a ‘superstar’ for mineralization of PAHs and dioxin‐like compounds - Weiwei Wang; Qinggang Li; Lige Zhang; Jie Cui; Hao Yu; Xiaoyu Wang; Xingyu Ouyang; Fei Tao; Ping Xu; Hongzhi Tang (Environmental Microbiology, 2021)
Summary Polycyclic aromatic hydrocarbons (PAHs) and dioxin‐like compounds, including sulfur, nitrogen and oxygen heterocycles, are widespread and toxic environmental pollutants. A wide variety of microorganisms capable of growing with aromatic polycyclic compounds are essential for bioremediation of the contaminated sites and the Earth's carbon cycle. Here, cells of Pseudomonas putida B6‐2 (ATCC BAA‐2545) grown in the presence of biphenyl (BP) are able to simultaneously degrade PAHs and their derivatives, even when they are present as mixtures, and tolerate high concentrations of extremely toxic solvents. Genetic analysis of the 6.37 Mb genome of strain B6‐2 reveals coexistence of gene clusters responsible for central catabolic systems of aromatic compounds and for solvent tolerance. We used functional transcriptomics and proteomics to identify the candidate genes associated with catabolism of BP and a mixture of BP, dibenzofuran, dibenzothiophene and carbazole. Moreover, we observed dynamic changes in transcriptional levels with BP, including in metabolic pathways of aromatic compounds, chemotaxis, efflux pumps and transporters potentially involved in adaptation to PAHs. This study on the highly versatile activities of strain B6‐2 suggests it to be a potentially useful model for bioremediation of polluted sites and for investigation of biochemical, genetic and evolutionary aspects of Pseudomonas .

Increasing Temperature Alters the Effects of Extracellular Copper on Thalassiosira Pseudonana Physiology and Transcription - Xinjie Wang; Wang Cao; Hong Du; Wenhua Liu; Ping Li (Journal of Marine Science and Engineering, 2021)
Copper (Cu) is essential for many physiological processes in phytoplankton, including electron-transfer reactions and high-affinity Fe transport systems. However, at high concentrations, Cu can have a toxic effect on phytoplankton. Phytoplankton’s tolerance to certain toxicants in marine ecosystems cannot always be solely attributed to the presence of compounds, as various environmental factors including temperature can also indirectly influence their effects on organisms. In this study, we investigated the effects of different Cu concentrations (0, 19.6, 160, 800, and 8000 nM) on the growth and physiological changes in the centric diatom Thalassiosira pseudonana (CCMP 1335) when simultaneously applied with temperature cultivation of 20 °C and 25 °C. At low (0 nM) and high (8000 nM) Cu concentrations, the growth rate of T. pseudonana was inhibited, though an increase in temperature lessened this inhibition. There were no significant changes in the POC:PON ratio during all of the treatments. However, increasing the temperature significantly decreased the POC: POP, PON: POP and BSi: POP ratios of T. pseudonana. The intracellular Cu content of T. pseudonana varied from 0.13 to 13.28 fg cell−1 in response to increases in ambient Cu concentrations. Lastly, an increase in the Cu concentration decreased the transcriptional expression of CTR (copper transporter), 3Hfcp (photosynthetic protein), and Sit1 (silica shell formation) encoding genes. In conclusion, our results indicated that T. pseudonana can adapt to physiological processes and molecular mechanisms in response to varying Cu concentrations and ambient temperatures.

Terpenoids from the South China Sea soft coral Sinularia multiflora - Zheng Wang; Ping-Lin Li; Xiang-Chao Luo; Qi Wang; Leen van Ofwegen; Xu-Li Tang; Guo-Qiang Li (Natural Product Research, 2021)

A new ent -kaurane diterpene from Isodon henryi - Xue Jiang; Ling-Xia Zhang; Qing-Mei Feng; Hong Wu; Ya-Lin Liu; De-Qin Wang; Li-Ping Dai; Zhi-Min Wang (Natural Product Research, 2021)

Development of a molecularly imprinted microspheres-based microplate fluorescence method for detection of amantadine and rimantadine in chicken - Teng Zhang; Lei Zhang; Ju Xiang Liu; Jian Ping Wang; Ning Peng Wu (Food Additives & Contaminants: Part A, 2021)

Cloud-Based Multidimensional Parallel Dynamic Programming Algorithm for a Cascade Hydropower System - Yufei Ma; Ping-an Zhong; Bin Xu; Feilin Zhu; Jieyu Li; Han Wang; Qingwen Lu (Water Resources Management, 2021)

The interval copula-measure Me based multi-objective multi-stage stochastic chance-constrained programming for seasonal water resources allocation under uncertainty - Youzhi Wang; Ping Guo (Stochastic Environmental Research and Risk Assessment, 2021)

Targeted drug delivery strategies for the treatment of rheumatoid arthritis - Jinxia Zhang; Ling Jiang; Lihong Sun; Ping Wang; Suhui Sun; Menghong Xu; Lulu Zhang; Shumin Wang; Xiaolong Liang; Ligang Cui (Science China Life Sciences, 2021)

Risk factors for sleep disorders in patients undergoing peritoneal dialysis - Gui-Ling Liu; Qiu-Nan Zhan; You-Lu Zhao; Zu-Ying Xiong; Jin-Lan Liao; Ye-Ping Ren; Qin Wang; Li-Ping Duan; Zhao-Xia Zheng; Li Hao; Jie Dong (Sleep and Biological Rhythms, 2021)
Sleep disorders in patients with end-stage renal disease are common but have rarely been reported in previous studies. Therefore, we examined the prevalence of sleep disorders and the risk factors for declining sleep quality in patients undergoing peritoneal dialysis (PD). A multicenter prospective cohort study was conducted at five PD centers across different provinces in China. A total of 449 patients who underwent PD between March to November 2013 were enrolled. Demographic data, laboratory indicators, presence of depression, and sleep assessment data were collected. Sleep questionnaires reflecting five categories of sleep disorders, namely, insomnia, restless legs syndrome, excessive daytime sleepiness, possible narcolepsy, and sleepwalking and nightmares, were administered at baseline and at 24 months postoperatively. Sleep disorders were diagnosed when a patient had at least one sleep problem. At baseline, 335 (74.6%) patients had at least one type of sleep disorder. Depression, diabetes mellitus (DM), and male were found to be associated with the presence of a sleep disorder. At follow-up, the prevalence of insomnia, restless legs syndrome, and excessive daytime sleepiness had significantly increased in 285 patients. Furthermore, cardiovascular disease (CVD) was found to be associated with the presence of sleep disorders in patients with one or more disorders at baseline, whereas a low serum albumin level was found to be associated with sleep disorders in patients without any sleep disorders at baseline. The prevalence of sleep disorders was relatively high among PD patients at baseline and increased afterthe2-year follow-up. Depression, DM, and male were associated with all sleep disorders at baseline. CVD was associated with the presence of a sleep disorder at baseline and worse sleep quality at the 2-year follow-up; whereas a low serum albumin level was associated with the risk of acquiring a sleep disorder at the 2-year follow-up among patients with normal sleep status at baseline.

Comparative analysis of sRNAs, degradome and transcriptomics in sweet sorghum reveals the regulatory roles of miRNAs in Cd accumulation and tolerance - Weitao Jia; Kangqi Lin; Tengxue Lou; Juanjuan Feng; Sulian Lv; Ping Jiang; Ze Yi; Xuan Zhang; Duoliya Wang; Zijing Guo; Yetao Tang; Rongliang Qiu; et al. (Planta, 2021)

Citrus NIP5;1 aquaporin regulates cell membrane water permeability and alters PIPs plasma membrane localization - Mingfei Zhang; Ruilian Liu; Hai Liu; Hongbin Yang; Xin Li; Ping Wang; Feng Zhu; Rangwei Xu; Shaowu Xue; Yunjiang Cheng (Plant Molecular Biology, 2021)

MdBZR1 regulates ABA response by modulating the expression of MdABI5 in apple - Ya-Jing Liu; Jian-Ping An; Xiao-Fei Wang; Ning Gao; Xun Wang; Shuai Zhang; Wen-Sheng Gao; Yu-Jin Hao; Chun-Xiang You (Plant Cell Reports, 2021)

Characteristics of RNA alternative splicing and its potential roles in ginsenoside biosynthesis in a single plant of ginseng, Panax ginseng C.A. Meyer - Yilai Han; Lei Zhu; Li Li; Yanfang Wang; Mingzhu Zhao; Kangyu Wang; Chunyu Sun; Jing Chen; Lingyu Liu; Ping Chen; Jun Lei; Yi Wang; et al. (Molecular Genetics and Genomics, 2021)

Potential effect of EGCG on the anti-tumor efficacy of metformin in melanoma cells - An’an Xu; Jeehyun Lee; Yueling Zhao; Yuefei Wang; Xiaoli Li; Ping Xu (Journal of Zhejiang University-SCIENCE B, 2021)

FSTL1 aggravates OVA-induced inflammatory responses by activating the NLRP3/IL-1β signaling pathway in mice and macrophages - Yan Wang; Dong Zhang; Tian Liu; Jun-fei Wang; Jin-xiang Wu; Ji-ping Zhao; Jia-wei Xu; Jin-tao Zhang; Liang Dong (Inflammation Research, 2021)

Evaluation of the differences between biofilm and planktonic Brucella abortus via metabolomics and proteomics - Taishan Tang; Ye Xu; Jianfeng Wang; Xiao Tan; Xiaona Zhao; Ping Zhou; Fande Kong; Changqing Zhu; Chengping Lu; Huixing Lin (Functional & Integrative Genomics, 2021)

Short-term exposure to particulate matter on heart rate variability in humans: a systematic review of crossover and controlled studies - Fangfang Huang; Yuhan Zhao; Ping Wang; Yingfang Wang; Licheng Zhang; Yanxia Luo (Environmental Science and Pollution Research, 2021)

Degradation of octylphenol polyethoxylates with a long ethoxylate chain using the laccase-mediated systems - Dan Wang; Jiangfei Lou; Jin Xu; Jiugang Yuan; Qiang Wang; Ping Wang; Xuerong Fan (Environmental Science and Pollution Research, 2021)

FABP regulates fatty acid metabolism and oxidative response via PPARα/RXR signaling in Litopenaeus vannamei following environmental exposure of clofibric acid - Chang-Sheng Zhao; Wei Wei; Sheng-Wei Luo; Ping Yang; Ying-Hao Ren; Yuan Liu; Wei-Na Wang (Ecotoxicology, 2021)

Blood Lead, Systemic Inflammation, and Blood Pressure: Exploring Associations and Mediation Effects in Workers Exposed to Lead - Ping He; Chengxin Yang; Dongkui He; Shiyu Zhao; Yujia Xie; Haijiao Wang; Jixuan Ma (Biological Trace Element Research, 2021)

Using seismic sedimentology in delineating a distributary channel type shallow-water lacustrine delta: first member of the Cretaceous Yaojia Formation in Changling area, South of Songliao Basin - Jun Wang; Kai Zeng; Bowen Wu; Jianzheng Ji; Zhidong Bao; Bin Cheng; Hongjing Zhang; Ping Xiong; Fan Diao (Arabian Journal of Geosciences, 2021)

Nitrated polycyclic aromatic compounds in the atmospheric environment: A review - Juping Yan; Xiaoping Wang; Ping Gong; Chuanfei Wang (Critical Reviews in Environmental Science and Technology, 2021)

Application of an enhanced BP neural network model with water cycle algorithm on landslide prediction - Yong-gang Zhang; Jun Tang; Rao-ping Liao; Ming-fei Zhang; Yan Zhang; Xiao-ming Wang; Zheng-yang Su (Stochastic Environmental Research and Risk Assessment, 2021)

3D DEM analysis on tractive trafficability of a lunar rover wheel with bionic wheel lugs - Hao Pang; Rui Zhang; Ping Ge; Fang Liu; Chengjin Wang; Wenchao Dong; Tao Li; Jianqiao Li (Rendiconti Lincei. Scienze Fisiche e Naturali, 2021)

Correction to: Genomic Action of Sigma-1 Receptor Chaperone Relates to Neuropathic Pain - Shao-Ming Wang; Nino Goguadze; Yuriko Kimura; Yuko Yasui; Bin Pan; Tzu-Yun Wang; Yoki Nakamura; Yu-Ting Lin; Quinn H. Hogan; Katherine L. Wilson; Tsung-Ping Su; Hsiang-en Wu (Molecular Neurobiology, 2021)
A correction to this paper has been published: 10.1007/s12035-021-02310-3

Genomic Action of Sigma-1 Receptor Chaperone Relates to Neuropathic Pain - Shao-Ming Wang; Nino Goguadze; Yuriko Kimura; Yuko Yasui; Bin Pan; Tzu-Yun Wang; Yoki Nakamura; Yu-Ting Lin; Quinn H. Hogan; Katherine L. Wilson; Tsung-Ping Su; Hsiang-en Wu (Molecular Neurobiology, 2021)
Sigma-1 receptors (Sig-1Rs) are endoplasmic reticulum (ER) chaperones implicated in neuropathic pain. Here we examine if the Sig-1R may relate to neuropathic pain at the level of dorsal root ganglia (DRG). We focus on the neuronal excitability of DRG in a “spare nerve injury” (SNI) model of neuropathic pain in rats and find that Sig-1Rs likely contribute to the genesis of DRG neuronal excitability by decreasing the protein level of voltage-gated Cav2.2 as a translational inhibitor of mRNA. Specifically, during SNI, Sig-1Rs translocate from ER to the nuclear envelope via a trafficking protein Sec61β. At the nucleus, the Sig-1R interacts with cFos and binds to the promoter of 4E-BP1, leading to an upregulation of 4E-BP1 that binds and prevents eIF4E from initiating the mRNA translation for Cav2.2. Interestingly, in Sig-1R knockout HEK cells, Cav2.2 is upregulated. In accordance with those findings, we find that intra-DRG injection of Sig-1R agonist (+)pentazocine increases frequency of action potentials via regulation of voltage-gated Ca2+ channels. Conversely, intra-DRG injection of Sig-1R antagonist BD1047 attenuates neuropathic pain. Hence, we discover that the Sig-1R chaperone causes neuropathic pain indirectly as a translational inhibitor.

Co-seismic landslide mapping using Sentinel-2 10-m fused NIR narrow, red-edge, and SWIR bands - Ping Lu; Wenyang Shi; Qunming Wang; Zhongbin Li; Yuanyuan Qin; Xuanmei Fan (Landslides, 2021)

Effects of Tobacco Stem-Derived Biochar on Soil Properties and Bacterial Community Structure under Continuous Cropping of Bletilla striata - Linyan Zhao; Huilin Guan; Rui Wang; Haoji Wang; Zecheng Li; Wei Li; Ping Xiang; Wumei Xu (Journal of Soil Science and Plant Nutrition, 2021)

IGF-1 Alleviates Mitochondrial Apoptosis through the GSK3β/NF-κB/NLRP3 Signaling Pathway in LPS-Treated PC-12 Cells - Feng Wang; Lu Wang; Guanghong Sui; Caixia Yang; Mengtian Guo; Xiangyang Xiong; Zheng Chen; Ping Lei (Journal of Molecular Neuroscience, 2021)

RHBDD1 silencing inhibited cell growth and invasion of non-small cell lung cancer by mediating ZEB1/PI3K/AKT signaling pathway - Zheyuan Xu; Ran Wang; Xu Li; Limin Yang; Hao Peng; Yang Wang; Ping Wang (Journal of Molecular Histology, 2021)

Cross-network interaction for diagnosis of major depressive disorder based on resting state functional connectivity - Xueling Zhu; Fulai Yuan; Gaofeng Zhou; Jilin Nie; Dongcui Wang; Ping Hu; Lirong Ouyang; Lingyu Kong; Weihua Liao (Brain Imaging and Behavior, 2021)
Previous studies have suggested that resting-state functional connectivity plays a central role in the physiopathology of major depressive disorder (MDD). However, the individualized diagnosis of MDD based on resting-state functional connectivity is still unclear, especially in first episode drug-naive patients with MDD. Resting state functional magnetic resonance imaging was enrolled from 30 first episode drug-naive patients with MDD and age- and gender-matched 31 healthy controls. Whole brain functional connectivity was computed and viewed as classification features. Multivariate pattern analysis (MVPA) was performed to discriminate patients with MDD from controls. The experimental results exhibited a correct classification rate of 82.25% ( p < 0.001) with sensitivity of 83.87% and specificity of 80.64%. Almost all of the consensus connections (125/128) were cross-network interaction among default mode network (DMN), salience network (SN), central executive network (CEN), visual cortex network (VN), Cerebellum and Other. Moreover, the supramarginal gyrus exhibited high discriminative power in classification. Our findings suggested cross-network interaction can be used as an effective biomarker for MDD clinical diagnosis, which may reveal the potential pathological mechanism for major depression. The current study further confirmed reliable application of MVPA in discriminating MDD patients from healthy controls.

Mass spectrometric analysis of digesta does not improve the allergenicity assessment of GM crops - Rod A. Herman; Patricia A. Bauman; Laurie Goodwin; Emir Islamovic; Eric H. Ma; Hector Serrano; Andre Silvanovich; Abigail R. Simmons; Ping Song; Afua O. Tetteh; Rong Wang (Transgenic Research, 2021)
An investigation of the potential allergenicity of newly expressed proteins in genetically modified (GM) crops comprises part of the assessment of GM crop safety. However, allergenicity is not completely predictable from a definitive assay result or set of protein characteristics, and scientific opinions regarding the data that should be used to assess allergenicity are continuously evolving. Early studies supported a correlation between the stability of a protein exposed to digestive enzymes such as pepsin and the protein’s status as a potential allergen, but over time the conclusions of these earlier studies were not confirmed. Nonetheless, many regulatory authorities, including the European Food Safety Authority (EFSA), continue to require digestibility analyses as a component of GM crop risk assessments. Moreover, EFSA has recently investigated the use of mass spectrometry (MS), to make digestion assays more predictive of allergy risk, because it can detect and identify small undigested peptides. However, the utility of MS is questionable in this context, since known allergenic peptides are unlikely to exist in protein candidates intended for commercial development. These protein candidates are pre-screened by the same bioinformatics processes that are normally used to identify MS targets. Therefore, MS is not a standalone allergen identification method and also cannot be used to predict previously unknown allergenic epitopes. Thus, the suggested application of MS for analysis of digesta does not improve the poor predictive power of digestion assays in identifying allergenic risk.

Generation and identification of endothelial-specific Hrh2 knockout mice - Rui Meng; Wen-Ke Cai; Wen-Mang Xu; Qiang Feng; Ping Wang; Yan-hua Huang; Yu-Xin Fan; Tao Zhou; Qin Yang; Zhi-Ran Li; Gong-Hao He (Transgenic Research, 2021)

LAI scale effect research based on compact airborne spectrographic imager data in the Heihe Oasis - Xiao-ai Dai; Chao Liu; Nai-wen Li; Mei-lian Wang; Yu-wei Yang; Xing-ping Yang; Shi-qi Zhang; Xu-wei He; Zheng-li Yang; Heng Lu; Jing-zhong Li; Ze-kun Wang (Journal of Mountain Science, 2021)

Comparison of in Vascular Bioreactors and In Vivo Models of Degradation and Cellular Response of Mg–Zn–Mn Stents - Ningling Zhou; Ping Li; Hua Qiu; Jin Wang; Nan Huang; Ansha Zhao; Juan Wang (Annals of Biomedical Engineering, 2021)

Cytotoxic p -terphenyls from the deep-sea-derived Aspergillus candidus - Yu-Kun Lin; Chun-Lan Xie; Cui-Ping Xing; Bao-Qu Wang; Xiao-Xue Tian; Jin-Mei Xia; Ling-Yun Jia; Ying-Ni Pan; Xian-Wen Yang (Natural Product Research, 2021)

Cytotoxic meroterpenoids from the marine sponge Dactylospongia elegans - Hao-Bing Yu; Zi-Fei Yin; Bin-Bin Gu; Jian-Peng Zhang; Shu-Ping Wang; Fan Yang; Hou-Wen Lin (Natural Product Research, 2021)

Nitrogen fertilization overweighs intercropping in promotion of dissolved organic carbon concentration and complexity in potato-cropped soil - Ding Wang; Ping Zhao; Rui Xiang; Shuran He; Yanli Zhou; Xinhua Yin; Guangqiang Long (Plant and Soil, 2021)

Reduction of OsMPK6 activity by a R89K mutation induces cell death and bacterial blight resistance in rice - Dongfei Wang; Hong Wang; Qunen Liu; Ranran Tu; Xingpeng Zhou; Yingxin Zhang; Weixun Wu; Ping Yu; Daibo Chen; Xiaodeng Zhan; Liyong Cao; Shihua Cheng; et al. (Plant Cell Reports, 2021)

Inhibition of ASIC-Mediated Currents by Activation of Somatostatin 2 Receptors in Rat Dorsal Root Ganglion Neurons - Ting-Ting Liu; Shuang Wei; Ying Jin; Chun-Yu Qiu; Wang-Ping Hu (Molecular Neurobiology, 2021)

Bi-allelic BRWD1 variants cause male infertility with asthenoteratozoospermia and likely primary ciliary dyskinesia - Ting Guo; Chao-Feng Tu; Dan-Hui Yang; Shui-Zi Ding; Cheng Lei; Rong-Chun Wang; Lv Liu; Xi Kang; Xiao-Qing Shen; Yi-Feng Yang; Zhi-Ping Tan; Yue-Qiu Tan; et al. (Human Genetics, 2021)

A complete atmospheric emission inventory of F, As, Se, Cd, Sb, Hg, Pb, and U from coal-fired power plants in Anhui Province, eastern China - Jian Chen; Bofei Zhang; Suan Zhang; Jian Zeng; Ping Chen; Wenzhong Liu; Xingming Wang (Environmental Geochemistry and Health, 2021)

Influence of impulse waves generated by rocky landslides on the pressure exerted on bank slopes - Ting Cao; Ping-yi Wang; Zhen-feng Qiu; Jing-xuan Ren (Journal of Mountain Science, 2021)

Emergent chikungunya fever and vertical transmission in Yunnan Province, China, 2019 - XiaoXiong Yin; Ting-Song Hu; HaiLin Zhang; YongHua Liu; ZhiJian Zhou; LeBin Liu; Ping Li; YiYin Wang; ZhaoLan Yang; Jing Yu; SiYu Chen; Fu-Qiang Zhang (Archives of Virology, 2021)

Genome sequencing and functional annotation of Bacillus sp. strain BS-Z15 isolated from cotton rhizosphere soil having antagonistic activity against Verticillium dahliae - Zhong-Yi Chen; Xieerwanimu Abuduaini; Nuramina Mamat; Qi-Lin Yang; Meng-Jun Wu; Xin-Rui Lin; Ru Wang; Rong-Rong Lin; Wei-Jun Zeng; Huan-Chen Ning; He-Ping Zhao; Jin-Yu Li; et al. (Archives of Microbiology, 2021)

Effect of fermentation bed on bacterial growth in the fermentation mattress material and cecum of ducks - Jian- mei Wang; Xin- meng Gan; Fa-jun Pu; Wan- xia Wang; Min Ma; Ling-li Sun; Ji-wei Hu; Bo Hu; Rong-ping Zhang; Li-li Bai; Liang Li; He-he Liu (Archives of Microbiology, 2021)

Genome analysis of Salmonella phage vB_SalM_8-19 (genus Rosemountvirus) - Cong Cong; Wei Bing Dong; Cui Hui Jing; Yuan Yu Yu; Xu Yong Ping; Wang Li Li; Li Shu Ying; Li Ji Bin; Xu Mu; Li Xiao Yu (Archives of Microbiology, 2021)

Epidemics and electricity CO2 emissions: a feedback investigation - Ya-Hui Huang; Ke Wang; Yiwei Wang; Chun-ping Chang (Air Quality, Atmosphere & Health, 2021)

Mega-Ship-Generated Tsunami: A Field Observation in Tampa Bay, Florida - Ping Wang; Jun Cheng (Journal of Marine Science and Engineering, 2021)
The displacement of a large amount of water in a moderate-sized estuary by a fast-moving mega-ship can generate tsunami-like waves. Such waves, generated by cruise ships, were observed in Tampa Bay, Florida, USA. Two distinct, long tsunami-like waves were measured, which were associated with the passage of a large cruise ship. The first wave had a period of 5.4 min and a height of 0.40 m near the shoreline. The second wave had a period of 2.5 min and was 0.23 m high. The peak velocity of the onshore flow during the second wave reached 0.65 m/s. The shorter, second wave propagated considerably faster than the first wave in the breaking zone. The measured wave celerity was less than 50% of the calculated values, using the shallow water approximation of the dispersion equation, suggesting that nonlinear effects play an important role. A fundamental similarity among the generation of tsunamis, as induced by mega-ships, landslides or earthquakes, is a process that causes a vertical velocity at the sea surface, where a freely propagating wave is produced. This mega-ship-generated tsunami provides a prototype field laboratory for systematically studying tsunami dynamics, particularly the strong turbulent flows associated with the breaking of a tsunami wave in the nearshore, and tsunami–land interactions. It also provides a realistic demonstration for public education, which is essential for the preparation and management of this unpreventable hazard.

Cladosporine A, a new indole diterpenoid alkaloid with antimicrobial activities from Cladosporium sp. - Xue Han; Xue-Feng Bao; Chuan-Xi Wang; Jun Xie; Xiao-Jun Song; Ping Dai; Guo-Dong Chen; Dan Hu; Xin-Sheng Yao; Hao Gao (Natural Product Research, 2021)

Aristololactam alkaloids from the roots of Dasymaschalon rostratum - Yue Wang; Wen-Hao Chen; Xiao-Ping Song; Chang-Ri Han (Natural Product Research, 2021)

Associations of Blood Pressure and Carotid Flow Velocity with Brain Volume and Cerebral Small Vessel Disease in a Community-Based Population - Shao-Yuan Chuang; Pei-Ning Wang; Liang-Kung Chen; Kun-Hsien Chou; Chih-Ping Chung; Chen-Huan Chen; Gary F. Mitchell; Wen-Harn Pan; Hao-Min Cheng (Translational Stroke Research, 2021)

Fine mapping QTL and mining genes for protein content in soybean by the combination of linkage and association analysis - Xiyu Li; Ping Wang; Kaixin Zhang; Shulin Liu; Zhongying Qi; Yanlong Fang; Yue Wang; Xiaocui Tian; Jie Song; Jiajing Wang; Chang Yang; Xu Sun; et al. (Theoretical and Applied Genetics, 2021)

Treatment of Aggressive T Cell Lymphoblastic Lymphoma/leukemia Using Anti-CD5 CAR T Cells - Jia Feng; Haichan Xu; Andrew Cinquina; Zehua Wu; Qi Chen; Ping Zhang; Xingen Wang; Huiming Shan; Lei Xu; Qian Zhang; Lihua Sun; Wenli Zhang; et al. (Stem Cell Reviews and Reports, 2021)
While treatment for B-cell malignancies has been revolutionized through the advent of CAR immunotherapy, similar strategies for T-cell malignancies have been limited. Additionally, T-cell leukemias and lymphomas can commonly metastasize to the CNS, where outcomes are poor and treatment options are associated with severe side effects. Consequently, the development of safer and more effective alternatives for targeting malignant T cells that have invaded the CNS remains clinically important. CD5 CAR has previously been shown to effectively target various T-cell cancers in preclinical studies. As IL-15 strengthens the anti-tumor response, we have modified CD5 CAR to secrete an IL-15/IL-15sushi complex. In a Phase I clinical trial, these CD5-IL15/IL15sushi CAR T cells were tested for safety and efficacy in a patient with refractory T-LBL with CNS infiltration. CD5-IL15/IL15sushi CAR T cells were able to rapidly ablate the CNS lymphoblasts within a few weeks, resulting in the remission of the patient’s lymphoma. Despite the presence of CD5 on normal T cells, the patient only experienced a brief, transient T-cell aplasia. These results suggest that CD5-IL15/IL15sushi CAR T cells may be a safe and useful treatment of T-cell malignancies and may be particularly beneficial for patients with CNS involvement. Graphical Abstract

The highly conserved rps12 gene in ferns provides strong evidence for decreased substitution rates in the inverted repeat region - Jingyao Ping; Aimin Li; Peipei Feng; Ming Zhu; Yingjuan Su; Ting Wang (Plant Systematics and Evolution, 2021)

IMPERFECTIVE EXINE FORMATION (IEF) is required for exine formation and male fertility in Arabidopsis - Kaiqi Wang; Xin Zhao; Chaoting Pang; Sida Zhou; Xuexue Qian; Nan Tang; Naiying Yang; Ping Xu; Xiaofeng Xu; Jufang Gao (Plant Molecular Biology, 2021)

Transcriptomic analysis of saffron at different flowering stages using RNA sequencing uncovers cytochrome P450 genes involved in crocin biosynthesis - Guangchun Gao; Jiming Wu; Bai Li; Qi Jiang; Ping Wang; Jun Li (Molecular Biology Reports, 2021)

Pramipexole attenuates 6-OHDA-induced Parkinson’s disease by mediating the Nurr1/NF-κB pathway - Hua Gao; Dan Wang; Yu-Ling Wang; Jie-Ping Mao; Sen Jiang; Xin-Ling Yang (Molecular Biology Reports, 2021)

Systematic analysis to identify transcriptome-wide dysregulation of Alzheimer’s disease in genes and isoforms - Cong Fan; Ken Chen; Jiaxin Zhou; Ping-pui Wong; Dan He; Yiqi Huang; Xin Wang; Tianze Ling; Yuedong Yang; Huiying Zhao (Human Genetics, 2021)

Increased depression risk for elderly women with high blood levels of strontium and barium - Jia Lv; Yan-ling Li; Wen-qiang Ren; Rong Li; Jian-rong Chen; Chao Bao; Zhi-ping Du; Shun Feng; Ling Gu; Hui Gao; Kai-yong Liu; Lin-sheng Yang; et al. (Environmental Chemistry Letters, 2021)

Simulation of the Q2 loess slope with seepage fissure failure and seismic response via discrete element method - Wenbin Chang; Ping Wang; Huijuan Wang; Shaofeng Chai; Yifan Yu; Shiyang Xu (Bulletin of Engineering Geology and the Environment, 2021)

Polymorphisms in the DC-SIGN gene and their association with the severity of hand, foot, and mouth disease caused by enterovirus 71 - Ya-Ping Li; Mu-Qi Wang; Chen-Rui Liu; Hui-Ling Deng; Yuan Wu; Shuang-Suo Dang; Li-Hong Xu (Archives of Virology, 2021)

Carbon monoxide-triggered health effects: the important role of the inflammasome and its possible crosstalk with autophagy and exosomes - Rong-Jane Chen; Yu-Hsuan Lee; Tzu-Hao Chen; Yu-Ying Chen; Ya-Ling Yeh; Ching-Ping Chang; Chien-Cheng Huang; How-Ran Guo; Ying-Jan Wang (Archives of Toxicology, 2021)

Release mechanisms of major DAMPs - Atsushi Murao; Monowar Aziz; Haichao Wang; Max Brenner; Ping Wang (Apoptosis, 2021)
Damage-associated molecular patterns (DAMPs) are endogenous molecules which foment inflammation and are associated with disorders in sepsis and cancer. Thus, therapeutically targeting DAMPs has potential to provide novel and effective treatments. When establishing anti-DAMP strategies, it is important not only to focus on the DAMPs as inflammatory mediators but also to take into account the underlying mechanisms of their release from cells and tissues. DAMPs can be released passively by membrane rupture due to necrosis/necroptosis, although the mechanisms of release appear to differ between the DAMPs. Other types of cell death, such as apoptosis, pyroptosis, ferroptosis and NETosis, can also contribute to DAMP release. In addition, some DAMPs can be exported actively from live cells by exocytosis of secretory lysosomes or exosomes, ectosomes, and activation of cell membrane channel pores. Here we review the shared and DAMP-specific mechanisms reported in the literature for high mobility group box 1, ATP, extracellular cold-inducible RNA-binding protein, histones, heat shock proteins, extracellular RNAs and cell-free DNA.

Polymetamorphic events in the Jiao-Liao-Ji Belt, North China Craton：Evidence from integrated zircon, xenotime, and monazite LA–ICP–MS U–Pb dating - Ping-Hua Liu; Fu-Lai Liu; Zhong-Hua Tian; Da Wang; Jia Cai; Wen Zhang (International Geology Review, 2021)

Chlamydia trachomatis induces autophagy by p62 in HeLa cell - Fuyan Wang; Hongbo Zhang; Xiaofang Lu; Quan Zhu; Tingting Shi; Rong Lu; Ping Yu; Lei Zhang; Yong Wang (World Journal of Microbiology and Biotechnology, 2021)

Re-use of wasted sludge to treat industrial pollutants - Ru Wang; Li-ping Yu; Bibi Saima Zeb; Lin-jie Yuan; Meng-yu Liu; Lin-jiang Yuan (Water, Air, & Soil Pollution, 2021)

Biopharmaceutics Applications of Physiologically Based Pharmacokinetic Absorption Modeling and Simulation in Regulatory Submissions to the U.S. Food and Drug Administration for New Drugs - Fang Wu; Heta Shah; Min Li; Peng Duan; Ping Zhao; Sandra Suarez; Kimberly Raines; Yang Zhao; Meng Wang; Ho-pi Lin; John Duan; Lawrence Yu; et al. (The AAPS Journal, 2021)

Effects of simulated drought stress on carotenoid contents and expression of related genes in carrot taproots - Rong-Rong Zhang; Ya-Hui Wang; Tong Li; Guo-Fei Tan; Jian-Ping Tao; Xiao-Jun Su; Zhi-Sheng Xu; Yong-Sheng Tian; Ai-Sheng Xiong (Protoplasma, 2021)

Decreased grain size1, a C3HC4-type RING protein, influences grain size in rice (Oryza sativa L.) - Xingjie Zhu; Shengzhong Zhang; Yaping Chen; Changlin Mou; Yunshuai Huang; Xi Liu; Jingli Ji; Jiangfeng Yu; Qixian Hao; Chunyan Yang; Mengying Cai; Thanhliem Nguyen; et al. (Plant Molecular Biology, 2021)

Retraction Note to: Resibufogenin suppresses tumor growth and inhibits glycolysis in ovarian cancer by modulating PIM1 - Qian Li; Chuanwu Jiang; Yan Wang; Minghua Wei; Huijin Zheng; Yanqi Xu; Xuegang Xu; Fengyu Jia; Kai Liu; Gang Sun; Jianhua Zang; Ping Mo (Naunyn-Schmiedeberg's Archives of Pharmacology, 2021)

Larva fish assemblage structure in three-dimensional floating wetlands and non-floating wetlands in the Changjiang River estuary - Xiaofeng Huang; Feng Zhao; Chao Song; Yi Chai; Qian Wang; Ping Zhuang (Journal of Oceanology and Limnology, 2021)

Tyrosine kinase Fyn promotes apoptosis after intracerebral hemorrhage in rats by activating Drp1 signaling - Li Zhang; Lu Wang; Han Xiao; Hui Gan; Hui Chen; Shuyue Zheng; Dan Jian; Xuan Zhai; Ning Jiang; Zhao Jing; Ping Liang (Journal of Molecular Medicine, 2021)

The Biological Role of Optimized Recombinant Oral Long-Acting Glucagon Like Peptide-1 and Its Impact on the Expression of Genes Associated with Glucose Metabolism of Diabetes - Shan He; Jie Zhang; Tao Wang; Ping Wu; Jianyun Liu; Minggang Li; Baicheng Ma (International Journal of Peptide Research and Therapeutics, 2021)

SUSCC: Secondary Construction of Feature Space based on UMAP for Rapid and Accurate Clustering Large-scale Single Cell RNA-seq Data - Hai-Yun Wang; Jian-ping Zhao; Chun-Hou Zheng (Interdisciplinary Sciences: Computational Life Sciences, 2021)