Shrub encroachment balances soil organic carbon pool by increasing carbon recalcitrance in a temperate herbaceous wetland - Xinhou Zhang; Shuangshuang Jiang; Wei Jiang; Wenwen Tan; Rong Mao (Plant and Soil, 2021)

Microvesicles derived from human umbilical cord mesenchyme promote M2 macrophage polarization and ameliorate renal fibrosis following partial nephrectomy via hepatocyte growth factor - Tao Du; Guanqun Ju; Jun Zhou; Liang Zhong; Lu Rong; Wenxia Chen; Xiaoli Zhang; Ruijin Zhou; Degang Ding; Tongyu Ji (Human Cell, 2021)

Surfactant-assisted adsorption of uranyl ions in aqueous solution on TiO2/polythiophene nanocomposite - Youqun Wang; Yinghui Xie; Zhiyang Zheng; Dejun Zeng; Ying Dai; Zhibin Zhang; Xiaohong Cao; Rong Zou; Yunhai Liu (Environmental Science and Pollution Research, 2021)

Remediation of Soil in a Deserted Arsenic Plant Site Using Synthesised MgAlFe-LDHs - Kai Zhong; Chaolan Zhang; Siwei Ren; He Huang; Qun Rong; Yongxin Zhou (Bulletin of Environmental Contamination and Toxicology, 2021)

Retrospective surveillance of porcine circovirus 4 in pigs in Inner Mongolia, China, from 2016 to 2018 - Zhuo Ha; Chengdong Yu; Changzhan Xie; Guanyu Wang; Ying Zhang; Pengfei Hao; Jinfeng Li; Zhuoxin Li; Yanwei Li; Fulong Rong; Fulong Nan; He Zhang; et al. (Archives of Virology, 2021)

Genotypic variation in nitrogen utilization efficiency in oilseed rape is related to the coordination of leaf senescence and root N uptake during reproductive stage - Huiying He; Yuyu Xie; Anyu Zhao; Wencong Hu; Xiao Guo; Anthony J. Miller; Xiaoming Wu; Biyun Chen; Rong Zhang; Hui Tian; Yajun Gao (Plant and Soil, 2021)

Transcutaneous Auricular Vagus Nerve Stimulation: From Concept to Application - Yu Wang; Shao-Yuan Li; Dan Wang; Mo-Zheng Wu; Jia-Kai He; Jin-Ling Zhang; Bin Zhao; Li-Wei Hou; Jun-Ying Wang; Lei Wang; Yi-Fei Wang; Yue Zhang; et al. (Neuroscience Bulletin, 2021)

Syntheses and anticancer activities of novel glucosylated (−)-epigallocatechin-3-gallate derivatives linked via triazole rings - Bo-Ya Shi; Ze-Hao Wang; Ning Zhang; Yin-Rong Xie; Xiu-Li Sun; Hao-Nan Yang; Yi-Long Wu; Cheng-Ting Zi; Xuan-Jun Wang; Jun Sheng (Medicinal Chemistry Research, 2021)

Effects of Diversified Cropping Sequences and Tillage Practices on Soil Organic Carbon, Nitrogen, and Associated Fractions in the North China Plain - Ahmad Latif Virk; Wen-Sheng Liu; Jia-Rui Niu; Cheng-Tang Xu; Qiu-Yue Liu; Zheng-Rong Kan; Xin Zhao; Hai-Lin Zhang (Journal of Soil Science and Plant Nutrition, 2021)

Zinc-based triazole metal complexes for efficient iodine adsorption in water - Jianxian Qin; Wei Zhang; Yuantao Chen; Rong Liu; Yuanrui Fan (Environmental Science and Pollution Research, 2021)

Mucor rongii sp. nov., a New Cold-Tolerant Species from China - Feirong Bai; Su Yao; Chengshan Cai; Tianci Zhang; Yu Wang; Wei Liu; Baowen Ma; Changyuan Rong; Chi Cheng (Current Microbiology, 2021)

Coupling ocean–atmosphere intensity determines ocean chlorophyll-induced SST change in the tropical Pacific - Feng Tian; Rong-Hua Zhang; Xiujun Wang (Climate Dynamics, 2021)

Correction to: Synthetic antimicrobial agents inhibit aflatoxin production - Jing Li; Qing-Qing Zhi; Jie Zhang; Xiao-Yu Yuan; Li-Hong Jia; Yu-Lin Wan; Qiu-Yun Liu; Jian-Rong Shi; Zhu-Mei He (Brazilian Journal of Microbiology, 2021)

Synthetic antimicrobial agents inhibit aflatoxin production - Jing Li; Qing-Qing Zhi; Jie Zhang; Xiao-Yu Yuan; Li-Hong Jia; Yu-Lin Wan; Qiu-Yun Liu; Jian-Rong Shi; Zhu-Mei He (Brazilian Journal of Microbiology, 2021)

Dietary Supplementation with Sea Cucumber Saponins and Exercise Can Significantly Suppress Adipose Accumulation in Mice Fed with High-Fat Diet - Rong Li; Jing Meng; Haohao Shi; Chengcheng Wang; Zhaojie Li; Changhu Xue; Yuming Wang; Tiantian Zhang (Journal of Ocean University of China, 2021)

Simplified calculation method for cumulative deformations of marine structured clay under cyclic loading - Meng Zang; Ling-wei Kong; Rong-tang Zhang; Wei-wei Wang (Arabian Journal of Geosciences, 2021)

Experimental Investigation on Physical and Mechanical Properties of Granite Subjected to Cyclic Heating and Liquid Nitrogen Cooling - Guan Rong; Song Sha; Bowen Li; Zhiheng Chen; Ziyang Zhang (Rock Mechanics and Rock Engineering, 2021)

Identification of two UDP-glycosyltransferases involved in the main oleanane-type ginsenosides in Panax japonicus var. major - Jun-Rong Tang; Geng Chen; Ying-Chun Lu; Qing-Yan Tang; Wan-Ling Song; Yuan Lin; Ying Li; Su-Fang Peng; Sheng-Chao Yang; Guang-Hui Zhang; Bing Hao (Planta, 2021)

Differential responses of litter decomposition in the air and on the soil surface to shrub encroachment in a graminoid-dominated temperate wetland - Xinhou Zhang; Wei Jiang; Shuangshuang Jiang; Wenwen Tan; Rong Mao (Plant and Soil, 2021)

Mesoscale wind stress-SST coupling induced feedback to the ocean in the western coast of South America - Chaoran Cui; Rong-Hua Zhang; Yanzhou Wei; Hongna Wang (Journal of Oceanology and Limnology, 2021)

Effect of fermentation bed on bacterial growth in the fermentation mattress material and cecum of ducks - Jian- mei Wang; Xin- meng Gan; Fa-jun Pu; Wan- xia Wang; Min Ma; Ling-li Sun; Ji-wei Hu; Bo Hu; Rong-ping Zhang; Li-li Bai; Liang Li; He-he Liu (Archives of Microbiology, 2021)

Comparative proteomic analysis of the fungal pathogen Neoscytalidium dimidiatum infection in the pitaya - Limei Pan; Rong Zhang; Fang Lu; Chengming Liu; Jiaxin Fu (Horticulture, Environment, and Biotechnology, 2021)

Molecular Characterization of Hsp47 in Grass Carp (Ctenopharyngodon idella) and Its Correlation with Type I Collagen in Response to Fish Aerobic Exercise - Xiao Liang; Ying Wan; Zhiyuan Shen; Yanmei Liu; Dapeng Li; Li Li; Rong Tang; Xi Zhang (Fishes, 2021)
Heat shock protein 47 (Hsp47) is a collagen-specific molecular chaperone that is indispensable for molecular maturation of collagen. In this study, hsp47 and hsp47-like cDNAs were cloned and characterized in grass carp (Ctenopharyngodon idella). The cDNAs were 1212 and 1218 base pairs long, respectively, and included an open reading frame encoding 403 and 405 amino acids. The molecular phylogeny based on the deduced amino acid sequences indicated that the correct sequences of the hsp47 and hsp47-like cDNA were obtained and the deduced proteins clustered distinctly into teleost clades. Primary structure analysis and characterization of Hsp47 and Hsp47-like shared the basic structure and biofunctions of Hsp47 in vertebrates. The spatial pattern of gene expression revealed that hsp47 and hsp47-like were relatively ubiquitous in different tissues and highly expressed in heart and skin. The expression levels of hsp47 and hsp47-like and type I collagen mRNAs varied similarly in different tissues. Type I collagen content increased significantly with the increase of water velocity in the muscle of grass carp in response to aerobic exercise. Among the gene expression changes of hsp47, hsp47-like, col1a1 and col1a2 in muscle that occurred in response to aerobic exercise, the change of type I collagen was most strongly correlated with hsp47 expression. Additionally, col1a1 showed the highest correlation with hsp47-like and col1a2 showed the highest correlation with hsp47. These findings suggest that grass carp Hsp47 and Hsp47-like are closely related to type I collagen synthesis. This study firstly suggests fish aerobic exercise can improve type I collagen content and Hsp47 gene expression in muscle of grass carp.

Triaxial Compression Testing at Constant and Reducing Confining Pressure for the Mechanical Characterization of a Specific Type of Sandstone - Jiu-chang Zhang; Zhi-nan Lin; Bo Dong; Rong-xin Guo (Rock Mechanics and Rock Engineering, 2021)

Genome-wide identification and characterization of long non-coding RNAs involved in flag leaf senescence of rice - Xiaoping Huang; Hongyu Zhang; Qiang Wang; Rong Guo; Lingxia Wei; Haiyan Song; Weigang Kuang; Jianglin Liao; Yingjin Huang; Zhaohai Wang (Plant Molecular Biology, 2021)
Key message This study showed the systematic identification of long non-coding RNAs (lncRNAs) involving in flag leaf senescence of rice, providing the possible lncRNA-mRNA regulatory relationships and lncRNA-miRNA-mRNA ceRNA networks during leaf senescence. Abstract LncRNAs have been reported to play crucial roles in diverse biological processes. However, no systematic identification of lncRNAs associated with leaf senescence in plants has been studied. In this study, a genome-wide high throughput sequencing analysis was performed using rice flag leaves developing from normal to senescence. A total of 3953 lncRNAs and 38757 mRNAs were identified, of which 343 lncRNAs and 9412 mRNAs were differentially expressed. Through weighted gene co-expression network analysis (WGCNA), 22 continuously down-expressed lncRNAs targeting 812 co-expressed mRNAs and 48 continuously up-expressed lncRNAs targeting 1209 co-expressed mRNAs were considered to be significantly associated with flag leaf senescence. Gene Ontology results suggested that the senescence-associated lncRNAs targeted mRNAs involving in many biological processes, including transcription, hormone response, oxidation–reduction process and substance metabolism. Additionally, 43 senescence-associated lncRNAs were predicted to target 111 co-expressed transcription factors. Interestingly, 8 down-expressed lncRNAs and 29 up-expressed lncRNAs were found to separately target 12 and 20 well-studied senescence-associated genes (SAGs). Furthermore, analysis on the competing endogenous RNA (CeRNA) network revealed that 6 down-expressed lncRNAs possibly regulated 51 co-expressed mRNAs through 15 miRNAs, and 14 up-expressed lncRNAs possibly regulated 117 co-expressed mRNAs through 21 miRNAs. Importantly, by expression validation, a conserved miR164-NAC regulatory pathway was found to be possibly involved in leaf senescence, where lncRNA MSTRG.62092.1 may serve as a ceRNA binding with miR164a and miR164e to regulate three transcription factors. And two key lncRNAs MSTRG.31014.21 and MSTRG.31014.36 also could regulate the abscisic-acid biosynthetic gene BGIOSGA025169 ( OsNCED4 ) and BGIOSGA016313 (NAC family) through osa-miR5809. The possible regulation networks of lncRNAs involving in leaf senescence were discussed, and several candidate lncRNAs were recommended for prior transgenic analysis. These findings will extend the understanding on the regulatory roles of lncRNAs in leaf senescence, and lay a foundation for functional research on candidate lncRNAs.

Involvement of Mitophagy in Aluminum Oxide Nanoparticle–Induced Impairment of Learning and Memory in Mice - Tao Huang; Weiwei Guo; Yanhong Wang; Lijun Chang; Nan Shang; Jin Chen; Rong Fan; Lan Zhang; Xiaocheng Gao; Qiao Niu; Qinli Zhang (Neurotoxicity Research, 2021)

Late Cretaceous granitic magmatism and Sn mineralization in the giant Yinyan porphyry tin deposit, South China: constraints from zircon and cassiterite U–Pb and molybdenite Re–Os geochronology - Peng-Cheng Hu; Wei-Guang Zhu; Hong Zhong; Rong-Qing Zhang; Xiao-Yu Zhao; Wei Mao (Mineralium Deposita, 2021)

A native Trichoderma harzianum strain Th62 displays antagonistic activities against phytopathogenic fungi and promotes the growth of Celosia cristata - Xue-Yue Hou; Yue-Feng Wang; Chuan-Ying Jiang; Tong-Tong Zhai; Rui Miao; Jun-Jie Deng; Zhi-Hong Yao; Rong-Shu Zhang (Horticulture, Environment, and Biotechnology, 2021)

Clinical and microbiological characteristics of adults with hospital-acquired pneumonia: a 10-year prospective observational study in China - Yuyao Yin; Chunjiang Zhao; Henan Li; Longyang Jin; Qi Wang; Ruobing Wang; Yawei Zhang; Jiangang Zhang; Hui Wang; Chunxia Yang; Bin Cao; Yingmei Liu; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Regenerable, anti-biofouling covalent organic frameworks for monitoring and extraction of uranium from seawater - Yi-Di Wu; Wei-Rong Cui; Cheng-Rong Zhang; Ru-Ping Liang; Jian-Ding Qiu (Environmental Chemistry Letters, 2021)

Comparative Transcriptomic Analyses of Haemophilus parasuis Reveal Differently Expressed Genes among Strains with Different Virulence Degrees - Yuan Y. Zhou; Chao Wang; Jing Yuan; Rong L. Yin; Xin Chen; Rui Li; Xue L. Zhang; Jing Wang; Chen Huang; Rong H. Yin (Current Microbiology, 2021)

Marinobacter shengliensis subsp. alexandrii Subsp. Nov., Isolated from Cultivable Phycosphere Microbiota of Highly Toxic Dinoflagellate Alexandrium catenella LZT09 and Description of Marinobacter shengliensis Subsp. shengliensis Subsp. Nov - Xi Yang; Rong Xiang; Nurhezreen Md Iqbal; Yu-Han Duan; Xiao-Ai Zhang; Lei Wang; Lin-Zeng Yu; Jia-Zhou Li; Ming-Fei Sun; Qiao Yang; Chun-Tian Zheng; Shen-Quan Liao (Current Microbiology, 2021)

Modification of the BQ system based on the Lugeon value and RQD: a case study from the Maerdang hydropower station, China - Kangda Chen; Yanhui Song; Yaolin Zhang; Huishi Xue; Juan Rong (Bulletin of Engineering Geology and the Environment, 2021)

Development of a Microfluidics-Based Quantitative Real-Time PCR to Rapidly Identify Photobacterium damselae subsp. damselae with Different Pathogenicity by Detecting the Presence of mcp or dly Gene - Zheng Zhang; Yongxiang Yu; Jing Chen; Yingeng Wang; Yong Jiang; Meijie Liao; Xiaojun Rong; Hao Zhang (Journal of Ocean University of China, 2021)

Chlamydia trachomatis induces autophagy by p62 in HeLa cell - Fuyan Wang; Hongbo Zhang; Xiaofang Lu; Quan Zhu; Tingting Shi; Rong Lu; Ping Yu; Lei Zhang; Yong Wang (World Journal of Microbiology and Biotechnology, 2021)

Anthracycline-Induced Cardiotoxicity: Molecular Insights Obtained from Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes (hiPSC-CMs) - William P. Bozza; Kazuyo Takeda; Wei-Lun Alterovitz; Chao-Kai Chou; Rong-Fong Shen; Baolin Zhang (The AAPS Journal, 2021)
Anthracyclines are a class of chemotherapy drugs that are highly effective for the treatment of human cancers, but their clinical use is limited by associated dose-dependent cardiotoxicity. The precise mechanisms by which individual anthracycline induces cardiotoxicity are not fully understood. Human-induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) are emerging as a physiologically relevant model to assess drugs cardiotoxicity. Here, we describe an assay platform by coupling hiPSC-CMs and impedance measurement, which allows real-time monitoring of cardiomyocyte cellular index, beating amplitude, and beating rate. Using this approach, we have performed comparative studies on a panel of four anthracycline drugs (doxorubicin, epirubicin, idarubicin, and daunorubicin) which share a high degree of structural similarity but are associated with distinct cardiotoxicity profiles and maximum cumulative dose limits. Notably, results from our hiPSC-CMs impedance model (dose-dependent responses and EC 50 values) agree well with the recommended clinical dose limits for these drugs. Using time-lapse imaging and RNAseq, we found that the differences in anthracycline cardiotoxicity are closely linked to extent of cardiomyocyte uptake and magnitude of activation/inhibition of several cellular pathways such as death receptor signaling, ROS production, and dysregulation of calcium signaling. The results provide molecular insights into anthracycline cardiac interactions and offer a novel assay system to more robustly assess potential cardiotoxicity during drug development.

Effects of simulated drought stress on carotenoid contents and expression of related genes in carrot taproots - Rong-Rong Zhang; Ya-Hui Wang; Tong Li; Guo-Fei Tan; Jian-Ping Tao; Xiao-Jun Su; Zhi-Sheng Xu; Yong-Sheng Tian; Ai-Sheng Xiong (Protoplasma, 2021)

Effect of bFGF on fibroblasts derived from the golden snub-nosed monkey - Xin Liu; Hao Wei; Jing Yang; Jingjing Li; Pei Zhang; Yuli Li; Rong Hou; Jinlian Hua; Xingrong Yan; Baoguo Li (Primates, 2021)

Retraction Note: Fibrauretine reduces ischemia/reperfusion injury via RISK/eNOS activation - Chunsheng Wang; Rong Chang; Gan Gao; Xing Liu; Yingwei Zhang (Naunyn-Schmiedeberg's Archives of Pharmacology, 2021)

Prevalence of Depression or Depressive Symptoms in Patients with Narcolepsy: a Systematic Review and Meta-Analysis - Xiao Li; Larry D. Sanford; Qiang Zong; Ye Zhang; Lu Tan; Taomei Li; Rong Ren; Junying Zhou; Fang Han; Xiangdong Tang (Neuropsychology Review, 2021)

Neobacillus sedimentimangrovi sp. nov., a Thermophilic Bacterium Isolated from Mangrove Sediment - Rong Tang; Qi Zhang; Manik Prabhu Narsing Rao; Guo-Hong Liu; Jian-Mei Che; Min Lei; Bo Liu; Wen-Jun Li; Shun-Gui Zhou (Current Microbiology, 2021)

Slight Increases in Salinity Improve Muscle Quality of Grass Carp (Ctenopharyngodon idellus) - Xi Zhang; Zhiyuan Shen; Tianpeng Qi; Rujuan Xi; Xiao Liang; Li Li; Rong Tang; Dapeng Li (Fishes, 2021)
Fish muscle quality is an important parameter in the aquaculture industry. In this study, we analyzed and compared the muscle quality of grass carp (Ctenopharyngodon idellus) cultured at salinities of 0‰, 3‰, and 6‰ (GC0, GC3, GC6). There was no significant difference in crude protein and crude fat content of muscle between GC0 and GC3. Crude fat was significantly lower in GC6 compared to the other groups. GC3 and GC6 had higher hydroxyproline content, which suggested that these groups had higher collagen content. GC3 and GC6 had higher contents of free amino acids and umami amino acids than GC0, but there was no significant difference in sweet or sour amino-acid content among groups. GC3 and GC6 had better texture properties, including hardness, gumminess, chewiness, resilience, and springiness, than GC0. GC3 had the highest water-holding capacity among the groups. As the salinity increased, the diameter of muscle fibers decreased and the sarcolemma showed a thickening trend. These results suggest that a slight increase in salinity (i.e., 3‰) can effectively improve the muscle quality of grass carp.

A New Record of Oxytricha granulifera granulifera Foissner and Adam, 1983 (Protozoa, Ciliophora, Oxytrichidae) From a Hot Spring in Iceland, With Notes on Its Abnormal Form During Cultivation - Rong Zhu; Zhishuai Qu; Qi Zhang; Sabine Filker; Thorsten Stoeck; Fengchao Li; Xiaozhong Hu (Frontiers in Marine Science, 2021)
We isolated a population of Oxytricha granulifera granulifera Foissner and Adam (1983) from a hot spring in Iceland. The pure culture of this isolate was established at room temperature in the laboratory. This allowed for a detailed investigation, informed by integrated approaches, of the isolate’s morphology and morphogenesis, as well as molecular phylogeny. Results showed that the morphological and morphogenetic characteristics of the Iceland population are consistent with those of other populations. During the 3-year long period of laboratory cultivation, some abnormal individuals appeared repeatedly in the culture system. Interestingly, the morphological characteristics of these abnormal cells were rather stable, and were as follows: 1) body slender and elliptical-shaped; 2) remarkably shortened adoral zone and significantly reduced number of adoral membranelles; and 3) loss of undulating membranes. Resting cysts, binary fission and conjugate reproduction were not found in abnormal specimens. Although the morphology of abnormal individuals changed significantly, the sequences of the SSU rDNA of the normal and abnormal morphotypes were the same. Phylogenetic analyses showed that the two morphotypes clustered in a clade with other populations of O. granulifera granulifera .

Long-term Outcomes and Risk Factors Related to Hydrocephalus After Intracerebral Hemorrhage - Rong Hu; Chao Zhang; Jiesheng Xia; Hongfei Ge; Jun Zhong; Xuanyu Fang; Yongjie Zou; Chuan Lan; Lan Li; Hua Feng (Translational Stroke Research, 2021)

Knockdown of Arginyl-tRNA Synthetase Attenuates Ischemia-Induced Cerebral Cortex Injury in Rats After Middle Cerebral Artery Occlusion - Yang Liu; Xue-Bin Hu; Li-Zhi Zhang; Zi Wang; Rong Fu (Translational Stroke Research, 2021)
Some researchers have previously shown that RNAi knockdown of arginyl-tRNA synthetase (ArgRS) before or after a hypoxic injury can rescue animals from death, based on the model organism, C. elegans . However, there has been no study on the application of arginyl-tRNA synthetase knockdown in treating mammalian ischemic stroke, and its potential mechanism and effect on ischemic brain damage are still unknown. Here, we focused on the Rars gene, which encodes an arginyl-tRNA synthetase, and examined the effects of Rars knockdown in a permanent middle cerebral artery occlusion model in rats. To achieve this aim, adult male Sprague-Dawley (SD) rats were given right cerebral cortex injections of short hairpin RNA (shRNA) adenovirus (AV) particles to knock down arginyl-tRNA synthetase, and a non-targeting control (NTC) vector or phosphate-buffered solution served as the controls. After 4 days, the rats were exposed to permanent middle cerebral artery occlusion (pMCAO). Then, the right cerebral cortex level of arginyl-tRNA synthetase was examined, and the effects of the Rars knockdown were evaluated by differences in infarction volume, oxidative stress, blood-brain barrier, mitochondrial function, and glucose metabolism at 1 day and 3 days after MCAO. The injection of shRNA adenovirus particles successfully suppressed the expression of arginyl-tRNA synthetase in the cerebral cortex. We observed an improvement in oxidative stress, mitochondrial function, and glucose utilization and a reduction in brain edema compared with the non-targeting control rats with suppressed expression of arginyl-tRNA synthetase mRNA in the ipsilateral ischemic cortex of the brain. Our findings indicate that knockdown of arginyl-tRNA synthetase in the cerebral cortex exerted neuroprotective effects, which were achieved not only by the improvement of oxidative stress and glucose utilization but also by the maintenance of mitochondrial morphological integrity and the preservation of mitochondrial function. Knockdown of ArgRS administration could be a promising approach to protect ischemic stroke.

Small RNA Sequencing Analysis of Germinating Single-bud Seedcane Sett in Sugarcane - Kai-Chao Wu; Lin Xu; Zhi-Nian Deng; Tian Pang; Rong-Hua Zhang; Yi-Jie Li; Xiao-Yan Liu; Cheng-Feng Huang; Wen-Xian Qin; Jian-Feng Wei; Li-Ping Wei; Yang-Rui Li; et al. (Sugar Tech, 2021)

Systematic identification and characterization of circular RNAs involved in flag leaf senescence of rice - Xiaoping Huang; Hongyu Zhang; Rong Guo; Qiang Wang; Xuanzhi Liu; Weigang Kuang; Haiyan Song; Jianglin Liao; Yingjin Huang; Zhaohai Wang (Planta, 2021)
Main conclusion Circular RNAs (circRNAs) identification, expression profiles, and construction of circRNA-parental gene relationships and circRNA-miRNA-mRNA ceRNA networks indicate that circRNAs are involved in flag leaf senescence of rice. Abstract Circular RNAs (circRNAs) are a class of 3′-5′ head-to-tail covalently closed non-coding RNAs which have been proved to play important roles in various biological processes. However, no systematic identification of circRNAs associated with leaf senescence in rice has been studied. In this study, a genome-wide high-throughput sequencing analysis was performed using rice flag leaves developing from normal to senescence. Here, a total of 6612 circRNAs were identified, among which, 113 circRNAs were differentially expressed (DE) during the leaf senescence process. Moreover, 4601 (69.59%) circRNAs were derived from the exons or introns of their parental genes, while 2110 (71%) of the parental genes produced only one circRNA. The sequence alignment analysis showed that hundreds of rice circRNAs were conserved among different plant species. Gene Ontology (GO) enrichment analysis revealed that parental genes of DE circRNAs were enriched in many biological processes closely related to leaf senescence. Through weighted gene co-expression network analysis (WGCNA), six continuously down-expressed circRNAs, 18 continuously up-expressed circRNAs and 15 turn-point high-expressed circRNAs were considered to be highly associated with leaf senescence. Additionally, a total of 17 senescence-associated circRNAs were predicted to have parental genes, in which, regulations of three circRNAs to their parental genes were validated by qRT-PCR. The competing endogenous RNA (ceRNA) networks were also constructed. And a total of 11 senescence-associated circRNAs were predicted to act as miRNA sponges to regulate mRNAs, in which, regulation of two circRNAs to eight mRNAs was validated by qRT-PCR. It is discussed that senescence-associated circRNAs were involved in flag leaf senescence probably through mediating their parental genes and ceRNA networks, to participate in several well-studied senescence-associated processes, mainly including the processes of transcription, translation, and posttranslational modification (especially protein glycosylation), oxidation–reduction process, involvement of senescence-associated genes, hormone signaling pathway, proteolysis, and DNA damage repair. This study not only showed the systematic identification of circRNAs involved in leaf senescence of rice, but also laid a foundation for functional research on candidate circRNAs.

Antidepressant Effect of Paeoniflorin Is Through Inhibiting Pyroptosis CASP-11/GSDMD Pathway - Dan-Dan Tian; Min Wang; An Liu; Mei-Rong Gao; Chen Qiu; Wen Yu; Wen-Ju Wang; Kun Zhang; Le Yang; Yan-Yan Jia; Chang-Bin Yang; Yu-Mei Wu (Molecular Neurobiology, 2021)

Rhizobium rhizolycopersici sp. nov., Isolated from the Rhizosphere Soil of Tomato Plants in China - Kyu Kyu Thin; Shan-Wen He; Xing Wang; Yao Wang; Ma Rong; Ji-Gang Han; Xiaoxia Zhang (Current Microbiology, 2021)

Correlation of exosomal microRNA clusters with bone metastasis in non-small cell lung cancer - Xiao-Rong Yang; Can Pi; Ruoying Yu; Xiao-Jun Fan; Xiao-Xiao Peng; Xu-Chao Zhang; Zhi-Hong Chen; Xue Wu; Yang Shao; Yi-Long Wu; Qing Zhou (Clinical & Experimental Metastasis, 2021)
20–40% of lung cancer patients develop bone metastasis (BM) with significantly decreased overall survival. Currently, BM is mainly diagnosed by computerized tomography (CT) scan or magnetic resonance imaging (MRI) when symptom develops. Novel biomarkers with higher prediction value of BM are needed. Plasma-derived exosomal microRNAs had been isolated and sequenced of total 30 non-small cell lung cancer (NSCLC) patients including 16 with bone metastasis and 14 without bone metastasis. Hierarchical clustering based on the total miRNA profile can clearly separate cancer patients and healthy individuals (H), but not patients with (BM +) or without (BM−) BM. Weight Co-expression network of miRNAs (WGCNA) analyses identified three consensus clusters (A, B, C) of highly correlated miRNAs, among which cluster B (144 miRNAs) showed significantly differential expression in lung cancer patients, especially in BM + group. Pathway analysis of cluster B miRNAs revealed enrichment in metabolic pathways that may involve in preconditioning of the metastatic niche. Three differentially expressed miRNAs between BM + and BM− patients within cluster B were identified as miR-574-5p, a suppressor of Wnt/β-catenin pathway, was down-regulated, while miR-328-3p and miR-423-3p, two activators of the same pathway, were up-regulated in BM + patients. Cluster A miRNAs (n = 49) also showed trend of upregulation in BM + patients. Interestingly, pathway analysis indicated that 43 of them are associated with chromosome14, which has been suggested to promote epithelial-mesenchymal transition (EMT) and bone metastasis.

Neuroanatomical substrates accounting for the effect of present hedonistic time perspective on risk preference: the mediating role of right posterior parietal cortex - Ting Xu; Zhiyi Chen; Fuschia M. Sirois; Rong Zhang; Yaqi Yang; Tingyong Feng (Brain Imaging and Behavior, 2021)

Selenium Deficiency via the TLR4/TRIF/NF-κB Signaling Pathway Leading to Inflammatory Injury in Chicken Spleen - Ruili Zhang; Rong Guo; Qing Liu; Guangxing Li; Bin Sun; Xiaodan Huang (Biological Trace Element Research, 2021)

The CMIP6 Historical Simulation Datasets Produced by the Climate System Model CAMS-CSM - Xinyao Rong; Jian Li; Haoming Chen; Jingzhi Su; Lijuan Hua; Zhengqiu Zhang; Yufei Xin (Advances in Atmospheric Sciences, 2021)
This paper describes the historical simulations produced by the Chinese Academy of Meteorological Sciences (CAMS) climate system model (CAMS-CSM), which are contributing to phase 6 of the Coupled Model Intercomparison Project (CMIP6). The model description, experiment design and model outputs are presented. Three members’ historical experiments are conducted by CAMS-CSM, with two members starting from different initial conditions, and one excluding the stratospheric aerosol to identify the effect of volcanic eruptions. The outputs of the historical experiments are also validated using observational data. It is found that the model can reproduce the climatological mean states and seasonal cycle of the major climate system quantities, including the surface air temperature, precipitation, and the equatorial thermocline. The long-term trend of air temperature and precipitation is also reasonably captured by CAMS-CSM. There are still some biases in the model that need further improvement. This paper can help the users to better understand the performance and the datasets of CAMS-CSM.

Infestation and distribution of gamasid mites on Himalayan field rat (Rattus nitidus) in Yunnan Province of Southwest China - Rong Xiang; Xian-Guo Guo; Cheng-Fu Zhao; Rong Fan; Ke-Yu Mao; Zhi-Wei Zhang; Xiao-Bin Huang (Biologia, 2021)

Neoproterozoic glaciations and rift evolution in the northwest Tarim Craton, China: new constraints from geochronological, geochemical, and geophysical data - Lin Wu; Shuwei Guan; Rong Ren; Chunyu Zhang; Xingqiang Feng (International Geology Review, 2021)

Construction and characterization of UAA-controlled recombinant Zika virus by genetic code expansion - Rong-Rong Zhang; Qing Ye; Xiao-Feng Li; Yong-Qiang Deng; Yan-Peng Xu; Xing-Yao Huang; Qing Xia; Cheng-Feng Qin (Science China Life Sciences, 2021)

Controlled-release N fertilizer to mitigate ammonia volatilization from double-cropping rice - Chang Tian; Xuan Zhou; Zheli Ding; Qiang Liu; Guixian Xie; Jianwei Peng; Xiangming Rong; Yuping Zhang; Yong Yang; Mamdouh A. Eissa (Nutrient Cycling in Agroecosystems, 2021)
Controlled-release nitrogen fertilizer (CRNF) can effectively enhance crop yields and raise the efficiency of nitrogen fertilizer in agroecosystems. In the present study, the volatilization of NH 3 was determined by airflow enclosure chamber technique after the application of different CRNF rates in double-cropping rice fields in southern China for continuous 3 years. The early and late season rice (ESR and LSR) were cultivated each year. The results showed that the total NH 3 volatilization losses ranged from 25 to 56 kg N ha −1 in ESR and from 32 to 61 kg N ha −1 in LSR. The loss of N to the total applied N ranged from 12 to 29% in ESR and from 12 to 27% in LSR. The application of CRNF significantly reduced the cumulative NH 3 volatilization losses by 20–43% for ESR and by 20–32% for LSR compared with conventional urea application. CRNF in LSR was less effective to reduce NH 3 volatilization than that in ESR. Furthermore, the application of 80% of N rate in the form of CRNF gave higher grain yield and apparent nitrogen recovery efficiency (ANRE) than that of application of 100% of N rate from conventional urea. CRNF can effectively reduce NH 3 volatilization, and increase rice yield and ANRE. Considering higher price of CRNF, the application of CRNF at lower (20% applied N) rate than conventional urea in LSR may be a reasonable fertilization strategy for improving N use efficiency, environment effectiveness, and sustaining the development of rice production systems in double-cropping rice.

Three pleiotropic loci associated with bone mineral density and lean body mass - Yu-Xue Zhang; Shan-Shan Zhang; Shu Ran; Yu Liu; Hong Zhang; Xiao-Lin Yang; Rong Hai; Hui Shen; Qing Tian; Hong-Wen Deng; Lei Zhang; Yu-Fang Pei (Molecular Genetics and Genomics, 2021)

Study on Characteristics of Shear Modulus of Zhanjiang Structured Clay During Triaxial Shearing - Meng Zang; Ling-wei Kong; Rong-tang Zhang; Wei-wei Wang (Geotechnical and Geological Engineering, 2021)

Risk of congenital heart disease due to exposure to common electrical appliances during early pregnancy: a case-control study - Doudou Zhao; Leqian Guo; Ruo Zhang; Qixia Zhu; Hongli Wang; Rong Liu; Hong Yan; Shaonong Dang (Environmental Science and Pollution Research, 2021)

Heavy metal concentrations and associated health risks in edible tissues of marine nekton from the outer Pearl River Estuary, South China Sea - Chang-Ping Yang; Yan Liu; Bin-Bin Shan; Jing Xu; Wei Yu; Dian-Rong Sun; Zai-Wang Zhang (Environmental Science and Pollution Research, 2021)

Thermal equation of state of phase egg (AlSiO3OH): implications for hydrous phases in the deep earth - Yungui Liu; Rong Huang; Ye Wu; Dongzhou Zhang; Junfeng Zhang; Xiang Wu (Contributions to Mineralogy and Petrology, 2021)

Geochemical characteristics and geological significance of chert nodules in Qixia formation, Pingding Mountain, lower Yangtze Plate - Jun Li; Lu-wang Chen; Chun-ming Hao; Jie Zhang; Song Chen; He-rong Gui (Journal of Mountain Science, 2021)

Red elemental selenium (Se 0 ) improves the immunoactivities of EPC cells, crucian carp and zebrafish against spring viraemia of carp virus - Jinbao Tian; Yong Zhang; Rong Zhu; Yeqing Wu; Xiaoxiao Liu; Xingguo Wang (Journal of Fish Biology, 2021)
Selenium, as an essential trace element, interferes through selenoproteins in many physiological processes of plants and mammals. Its antiviral activity has recently attracted much attention because selenium improves the antiviral capacity of animal cells against a few viruses relevant to human diseases. In this study, the red elemental selenium was purified from the fermentative culture of Herbaspirillum camelliae WT00C and then used to culture epithelioma papulosum cyprinid (EPC) cells or feed crucian carp and zebrafish. Finally, its antiviral effects were investigated at the cell level and living fishes after spring viraemia of carp virus infection. At the cell level, 5, 10 and 20 μg ml –1 red elemental selenium significantly induced the expression of interferon ( IFN ) and ISG 15 genes in EPC cells. The viral TCID 50 (50% tissue culture infective dose) values in the EPC cells incubated with 5, 10 and 20 μg ml –1 red elemental selenium were significantly less than those of the control. More expression of IFN and ISG 15 genes and less TCID 50 values indicate that red elemental selenium indeed improves the antiviral capability of EPC cells. In the crucian carp fed with the food containing 5 and 10 μg g –1 red elemental selenium, IFN expressions showed 13‐ and 39‐fold increases at the 16th day of post‐injection, and its expression was dependent on selenium concentrations. Meanwhile, no fish death occurred in all the experimental groups. In the zebrafish fed with the red worm containing 5 μg g –1 red elemental selenium, IFN and Mx expressions and survival rate were significantly higher than those of the control. The results of this study show that red elemental selenium indeed improves the antiviral activity of fish. The antiviral effects of selenium mainly come from its immune regulation through its incorporation into selenoproteins. The optimum level of selenium contributes to improving fish immunity, whereas excess selenium causes excessive immune and inflammatory responses.

Review of Estimating Trophic Relationships by Quantitative Fatty Acid Signature Analysis - Junbo Zhang; Chonglan Ren; Hu Zhang; Fang Yin; Shuo Zhang; Rong Wan; Daisuke Kitazawa (Journal of Marine Science and Engineering, 2020)
The dynamic predator–prey relations in the food web are vital for understanding the function and structure of ecosystems. Dietary estimation is a research hotspot of quantitative ecology, providing key insights into predator–prey relationships. One of the most promising approaches is quantitative fatty acid signature analysis (QFASA), which is the first generation of statistical tools to estimate the quantitative trophic predator–prey relationships by comparing the fatty acid (FA) signatures among predators and their prey. QFASA has been continuously widely applied, refined and extended since its introduction. This article reviewed the research progress of QFASA from development and application. QFASA reflects the long-term diet of predator, and provides the quantitative dietary composition of predator, but it is sensitive to the metabolism of predator. The calibration coefficients (CCs) and the FA subset are two crucial parameters to explain the metabolism of predators, but the incorrect construction or improper use of CCs and the FA subset may cause bias in dietary estimation. Further study and refinement of the QFASA approach is needed to identify recommendations for which CCs and subsets of FA work best for different taxa and systems.

Phytochemical and antitumor studies on Cynanchum mongolicum (Maxim.) Kom - Yong-Cheng Yang; Yan-Ming Wang; Zi-Jian Rong; Li-Na Hong; Qian Zhang; Jing-Ming Jia; An-Hua Wang (Natural Product Research, 2020)

Flavonoids as key bioactive components of Oxytropis falcata bunge, a traditional anti-inflammatory and analgesic Tibetan medicine - Mei-Rong Zhang; Kan Jiang; Jun-Li Yang; Yan-Ping Shi (Natural Product Research, 2020)

Mapping quantitative trait loci associated with stem-related traits in maize (Zea mays L.) - Qiqi Shang; Degui Zhang; Rong Li; Kaixin Wang; Zimeng Cheng; Zhiqiang Zhou; Zhuanfang Hao; Jinbao Pan; Xinhai Li; Liyu Shi (Plant Molecular Biology, 2020)

Quantitative Determination of Glymphatic Flow Using Spectrophotofluorometry - Yu Zhang; Jian Song; Xu-Zhong He; Jian Xiong; Rong Xue; Jia-Hao Ge; Shi-Yu Lu; Die Hu; Guo-Xing Zhang; Guang-Yin Xu; Lin-Hui Wang (Neuroscience Bulletin, 2020)

Lycium barbarum polysaccharide protects against Homocysteine-induced Vascular smooth muscle cell proliferation and phenotypic transformation via PI3K/Akt pathway - Minghao Zhang; Fan Li; Smritee Pokharel; Ting Ma; Xiuyu Wang; Yiyong Wang; Weirong Wang; Rong Lin (Journal of Molecular Histology, 2020)

Management of Gout-associated MSU crystals-induced NLRP3 inflammasome activation by procyanidin B2: targeting IL-1β and Cathepsin B in macrophages - Chun-Ying Qiao; Ying Li; Yue Shang; Min Jiang; Jian Liu; Zi-Ying Zhan; Huan Ye; Yong-Ce Lin; Jing-Ya Jiao; Rong-Hui Sun; Zhi-Hong Zhang; Mei-Hua Piao; et al. (Inflammopharmacology, 2020)

The TOR pathway participates in the regulation of growth development in juvenile spotted drum (Nibea diacanthus) under different dietary hydroxyproline supplementation - Hua Rong; Fan Lin; Yunlong Zhang; Baoliang Bi; Tengfei Dou; Xiangwei Wu; Jude Juventus Aweya; Xiaobo Wen (Fish Physiology and Biochemistry, 2020)

Prenatal diagnosis and neonatal phenotype of a de novo microdeletion of 17p11.2p12 associated with Smith‒Magenis syndrome and external genital defects - Pingping Zhang; Yanmei Sun; Haishen Tian; Limin Rong; Fangna Wang; Xiaoping Yu; Yali Li; Jian Gao (Journal of Genetics, 2020)

Comparative analysis of microsatellite and SNP markers for parentage testing in the golden snub-nosed monkey (Rhinopithecus roxellana) - Chen Ling; Wu Lixia; Hou Rong; Shen Fujun; Zhang Wenping; Tang Yao; Yuan Yaohua; Zhao Bo; Zhang Liang (Conservation Genetics Resources, 2020)
Microsatellite markers are popular for assigning parentage, but single-nucleotide polymorphisms (SNPs) have only been applied in this area recently. To evaluate these two markers which have been previously studied in golden snub-nosed monkeys, we genotyped 12 individuals using 37 microsatellite loci and 37 SNP markers. The data showed that 32 of 37 microsatellite loci were polymorphic, and most microsatellite loci were high informative (mean PIC = 0.599). Meanwhile, 24 of 37 SNP markers were polymorphic and most were low informative (mean PIC = 0.244). For microsatellites, the combined exclusion probability with one-parent-unknown/known (CE-1P/CE-2P) nearly reached 1, while for the SNP markers, CE-2P only reached 0.9582. Under the condition of one parent known/unknown, the CE-2P and CE-1P could meet the international human parental standard (0.9973) by using five or nine microsatellite loci respectively. For SNP markers, we doubled the loci (n = 48) and simulated parentage testing, and the data showed that the CE-2P was 0.998 while the CE-1P was still low. This result indicated that the SNP loci which we used here had low polymorphism and that more loci need to be developed in the future. In addition, we corrected one case of failed identification by excluding siblings and reducing the range of candidate paternities.

The intestine of artificially bred larval turbot (Scophthalmus maximus) contains a stable core group of microbiota - Zheng Zhang; Yongxiang Yu; Yan Jiang; Yingeng Wang; Meijie Liao; Xiaojun Rong; Qian Liu (Archives of Microbiology, 2020)

Soil bio-cementation using an improved 2-step injection method - Ming-Juan Cui; Jun-Jie Zheng; Rong-Jun Zhang; Han-Jiang Lai (Arabian Journal of Geosciences, 2020)

Sulfide ore prospecting in carbon-containing stratum using comprehensive time-domain induced polarization and controlled-source audio-frequency magnetotellurics - Ren-Bin Sun; Li-Xia Chu; Gui-Bin Zhang; Qiu-Ming Cheng; Yun-Chuan Xiang; Bin Hu; Chang-Rong Zhang; Jian-Fu Li; Yi-Jun Zhao (Applied Geophysics, 2020)

FgPal1 regulates morphogenesis and pathogenesis in Fusarium graminearum - Jinrong Yin; Chaofeng Hao; Gang Niu; Wei Wang; Guanghui Wang; Ping Xiang; Jin‐Rong Xu; Xue Zhang (Environmental Microbiology, 2020)
Summary Ascospores are the primary inoculum in Fusarium graminearum , a causal agent of wheat head blight. In a previous study, FgPAL1 was found to be upregulated in the Fgama1 mutant and important for ascosporogenesis. However, the biological function of this well‐conserved gene in filamentous ascomycetes is not clear. In this study, we characterized its functions in growth, differentiation and pathogenesis. The Fgpal1 mutant had severe growth defects and often displayed abnormal hyphal tips. It was defective in infectious growth in rachis tissues and spreading in wheat heads. The Fgpal1 mutant produced conidia with fewer septa and more nuclei per compartment than the wild type. In actively growing hyphal tips, FgPal1‐GFP mainly localized to the subapical collar and septa. The FgPal1 and LifeAct partially co‐localized at the subapical region in an interdependent manner. The Fgpal1 mutant was normal in meiosis with eight nuclei in developing asci but most asci were aborted. Taken together, our results showed that FgPal1 plays a role in maintaining polarized tip growth and coordination between nuclear division and cytokinesis, and it is also important for infectious growth and developments of ascospores by the free cell formation process.

Shortening the sgRNA-DNA interface enables SpCas9 and eSpCas9(1.1) to nick the target DNA strand - Rong Fan; Zhuangzhuang Chai; Sinian Xing; Kunling Chen; Fengti Qiu; Tuanyao Chai; Jin-Long Qiu; Zhengbin Zhang; Huawei Zhang; Caixia Gao (Science China Life Sciences, 2020)

Divergence in flowering time is a major component contributing to reproductive isolation between two wild rice species (Oryza rufipogon and O. nivara) - Xun Xu; Qing-Lin Meng; Mu-Fan Geng; Ning-Ning Ren; Lian Zhou; Yu-Su Du; Zhe Cai; Mei-Xia Wang; Xin Wang; Xiu-Hua Wang; Jing-Dan Han; Shuai Jiang; et al. (Science China Life Sciences, 2020)

Experimental Evaluation of Physical and Mechanical Properties of Geothermal Reservoir Rock after Different Cooling Treatments - Song Sha; Guan Rong; Zhiheng Chen; Bowen Li; Ziyang Zhang (Rock Mechanics and Rock Engineering, 2020)

Cytokinin (6-benzylaminopurine) elevates lignification and the expression of genes involved in lignin biosynthesis of carrot - Ahmed Khadr; Ya-Hui Wang; Rong-Rong Zhang; Xin-Rui Wang; Zhi-Sheng Xu; Ai-Sheng Xiong (Protoplasma, 2020)

Small grain and semi-dwarf 3, a WRKY transcription factor, negatively regulates plant height and grain size by stabilizing SLR1 expression in rice - Jie Lan; Qibing Lin; Chunlei Zhou; Yakun Ren; Xi Liu; Rong Miao; Ruonan Jing; Changling Mou; Thanhliem Nguyen; Xingjie Zhu; Qian Wang; Xin Zhang; et al. (Plant Molecular Biology, 2020)

Influence of soil moisture content on pullout properties of Hippophae rhamnoides Linn. roots - Chao-bo Zhang; Ya-ting Liu; Dong-rong Li; Jing Jiang (Journal of Mountain Science, 2020)

PSD-93 Interacts with SynGAP and Promotes SynGAP Ubiquitination and Ischemic Brain Injury in Mice - Qingxiu Zhang; Hui Yang; Hong Gao; Xiaomei Liu; Qingjie Li; Rong Rong; Zhenqian Liu; Xiu-e Wei; Liping Kong; Yun Xu; Liangqun Rong (Translational Stroke Research, 2020)

Identification, functional characterization, and estrogen regulation on gonadotropin-releasing hormone in the spotted scat, Scatophagus argus - Hua-pu Chen; Xue-fan Cui; Yao-rong Wang; Zhi-yuan Li; Chang-xu Tian; Dong-neng Jiang; Chun-Hua Zhu; Yong Zhang; Shui-sheng Li; Guang-li Li (Fish Physiology and Biochemistry, 2020)

Grape seed proanthocyanidin extract ameliorates hepatic lipid accumulation and inflammation in grass carp (Ctenopharyngodon idella) - Rong-Hua Lu; Chao-Bin Qin; Feng Yang; Wen-Ya Zhang; Yu-Ru Zhang; Guo-Kun Yang; Li-Ping Yang; Xiao-Lin Meng; Xiao Yan; Guo-Xing Nie (Fish Physiology and Biochemistry, 2020)

The impact of particulate matter 2.5 on the risk of preeclampsia: an updated systematic review and meta-analysis - Hongbiao Yu; Yangxue Yin; Jiashuo Zhang; Rong Zhou (Environmental Science and Pollution Research, 2020)
There is increasing and inconsistent evidence of a linkage between maternal exposure to particulate matter 2.5 (PM2.5) and preeclampsia. Therefore, this study was conducted to investigate this relationship. Electronic databases including PubMed, Embase, Web of Science, and Cochrane Library were searched to identify articles published from inception to March 23, 2020, which showed a correlation between PM2.5 and preeclampsia. Finally, 9 of 523 initial studies were deemed eligible for inclusion. A random effect model was adopted to calculate the standardized odds ratio (OR) and 95% confidence interval (CI). Based on potential effect modification, subgroup analyses were further performed. Meta-analysis showed that maternal exposure to PM2.5 (per 10 μg/m 3 increment) elevated the risk of preeclampsia (OR = 1.32, 95% CI 1.10 to 1.58%). Compared with other pregnancy trimesters, the third trimester of pregnancy seems to be the period in which women are more susceptible to PM2.5. Significant effect modification of the correlation between PM2.5 exposure and preeclampsia according to multiple pregnancies, pregnancy stage, maternal-related disease history, and sample size was not observed. The results demonstrated that maternal exposure to PM2.5 may predispose pregnant women to develop preeclampsia, especially in the third trimester of pregnancy. Therefore, more efforts should be made to improve air quality to maintain the health of pregnant women.

Model test of the stability degradation of a prestressed anchored rock slope system in a corrosive environment - Cong Li; Rong-tang Zhang; Jie-bing Zhu; Zhi-jun Liu; Bo Lu; Bin Wang; Yu-zhou Jiang; Jie-sheng Liu; Ping Zeng (Journal of Mountain Science, 2020)

Application of Lightning Data Assimilation to Numerical Forecast of Super Typhoon Haiyan (2013) - Rong Zhang; Wenjuan Zhang; Yijun Zhang; Jianing Feng; Liangtao Xu (Journal of Meteorological Research, 2020)

NLRP6 contributes to inflammation and brain injury following intracerebral haemorrhage by activating autophagy - Han Xiao; Hui Chen; Rong Jiang; Li Zhang; Lu Wang; Hui Gan; Ning Jiang; Jing Zhao; Xuan Zhai; Ping Liang (Journal of Molecular Medicine, 2020)

Changes in leaf vein traits among vein types of alpine grassland plants on the Tibetan Plateau - Chang-shun Wang; Wang-wang Lyu; Li-li Jiang; Shi-ping Wang; Qi Wang; Fan-dong Meng; Li-rong Zhang (Journal of Mountain Science, 2020)

Ecological analysis of gamasid mites on the body surface of Norway rats (Rattus norvegicus) in Yunnan Province, Southwest China - Zhe Liu; Xian-Guo Guo; Rong Fan; Cheng-Fu Zhao; Ke-Yu Mao; Zhi-Wei Zhang; Yue Zhao (Biologia, 2020)

Ice sheet controls on fine-grained deposition at the southern Mendeleev Ridge since the penultimate interglacial - Liming Ye; Xiaoguo Yu; Weiyan Zhang; Rong Wang (Acta Oceanologica Sinica, 2020)

Optimized Algorithm for Processing Outlier of Water Current Data Measured by Acoustic Doppler Velocimeter - Chunyi Zhong; Fang Yin; Junbo Zhang; Shuo Zhang; Rong Wan; Daisuke Kitazawa (Journal of Marine Science and Engineering, 2020)
In the process of pond culture, the usage of an aeration device can increase dissolved oxygen density and form a decent circulation which facilitates the collection of sludge. Acoustic Doppler Velocimeter (ADV) has been widely used to monitor the flow velocity, however, factors such as bubbles and suspended particles can affect the correlation coefficient and signal-to-noise ratio of ADV, which leads to the existence of outliers in velocity data. This study constructs the three-dimensional rousseeuw phase-space (3DRPS) method by optimizing the phase space threshold method and robust estimation method through two-step filtering and three-dimensional simultaneous measurement, where the outliers close to the real value can be detected more accurately and the iterative process can be reduced more effectively. The results show that the detection rate of the optimized 3DRPS method is approximately 99%. It is a promising method that effectively improves the accuracy of outlier detection and greatly reduces the phenomenon of over processing.

Neo-debromoaplysiatoxin C, with new structural rearrangement, derived from debromoaplysiatoxin - Yang-Hua Tang; Ting-Ting Liang; Ting-Ting Fan; Lawrence Jordan Keen; Xiao-Dan Zhang; Lin Xu; Qi Zhao; Rong Zeng; Bing-Nan Han (Natural Product Research, 2020)

Rapid identification and analysis of the major chemical constituents from the fruits of Sapindus mukorossi by HPLC-ESI-QTOF-MS/MS - Yun Ling; Qing Zhang; Wenjuan Zhong; Mengping Chen; Haonan Gong; Shasha He; Rong Liang; Jiao Lv; Liyuan Song (Natural Product Research, 2020)

Effective identification of CRISPR/Cas9-induced and naturally occurred mutations in rice using a multiplex ligation-dependent probe amplification-based method - Sukumar Biswas; Rong Li; Jun Hong; Xiangxiang Zhao; Zheng Yuan; Dabing Zhang; Jianxin Shi (Theoretical and Applied Genetics, 2020)

Molecular Characterization and Promoter Analysis of Novel Sugar Transporter Gene ScERD6 in Sugarcane - Xiao-Rong Miao; Xu-Peng Zeng; Jun-Qi Niu; Aamir Mahmood; Li-Tao Yang; Bao-Qing Zhang; Yang-Rui Li (Sugar Tech, 2020)

Aluminum-Induced Cognitive Impairment and PI3K/Akt/mTOR Signaling Pathway Involvement in Occupational Aluminum Workers - Nan Shang; Ping Zhang; Shuo Wang; Jianping Chen; Rong Fan; Jin Chen; Tao Huang; Yanhong Wang; Jeremy Duncan; Ling Zhang; Qiao Niu; Qinli Zhang (Neurotoxicity Research, 2020)

Responses of Primary Afferent Fibers to Acupuncture-Like Peripheral Stimulation at Different Frequencies: Characterization by Single-Unit Recording in Rats - Ran Huo; Song-Ping Han; Feng-Yu Liu; Xiao-Jing Shou; Ling-Yu Liu; Tian-Jia Song; Fu-Jun Zhai; Rong Zhang; Guo-Gang Xing; Ji-Sheng Han (Neuroscience Bulletin, 2020)

RETRACTED ARTICLE: Fibrauretine reduces ischemia/reperfusion injury via RISK/eNOS activation - Chunsheng Wang; Rong Chang; Gan Gao; Xing Liu; Yingwei Zhang (Naunyn-Schmiedeberg's Archives of Pharmacology, 2020)

Comparison of the effects of deep and moderate neuromuscular block on respiratory system compliance and surgical space conditions during robot-assisted laparoscopic radical prostatectomy: a randomized clinical study - Shao-jun Zhu; Xiao-lin Zhang; Qing Xie; Yan-feng Zhou; Kui-rong Wang (Journal of Zhejiang University-SCIENCE B, 2020)

Two novel pleiotropic loci associated with osteoporosis and abdominal obesity - Lu Liu; Xiao-Lin Yang; Hong Zhang; Zi-Jia Zhang; Xin-Tong Wei; Gui-Juan Feng; Ju Liu; Hui-Ping Peng; Rong Hai; Hui Shen; Qing Tian; Hong-Wen Deng; et al. (Human Genetics, 2020)

Retraction Note to: Explore on the effect of ATF6 on cell growth and apoptosis in cartilage development - Xiaofeng Han; Peng Zhang; Rong Jiang; Fei Xia; Meiling Li; Feng‑Jin Guo (Histochemistry and Cell Biology, 2020)

Removal of boron from water by GO/ZIF-67 hybrid material adsorption - Guangzhuang Hu; Wei Zhang; Yuantao Chen; Cheng Xu; Rong Liu; Zhen Han (Environmental Science and Pollution Research, 2020)

The late parietal event-related potential component is hierarchically sensitive to chunk tightness during chunk decomposition - Zhonglu Zhang; Zheyi Lu; Christopher M. Warren; Cuiliang Rong; Qiang Xing (Cognitive Neurodynamics, 2020)

Remediation of Cd, Pb and as Co-contaminated Paddy Soil by Applying Different Amendments - Xinyu Nong; Chaolan Zhang; Hexiao Chen; Qun Rong; Hefeng Gao; Xiaodan Jin (Bulletin of Environmental Contamination and Toxicology, 2020)

Biochemical Toxicity and Potential Detoxification Mechanisms in Earthworms Eisenia fetida Exposed to Sulfamethazine and Copper - Hong Rong; Chengrun Wang; Haitao Liu; Min Zhang; Yueting Yuan; Yanjie Pu; Jin Huang; Jinyu Yu (Bulletin of Environmental Contamination and Toxicology, 2020)

Fluoride-Induced Alteration in the Diversity and Composition of Bacterial Microbiota in Mice Colon - Rong Fu; Ruiyan Niu; Rui Li; Baijuan Yue; Xuhua Zhang; Qiqi Cao; Jundong Wang; Zilong Sun (Biological Trace Element Research, 2020)

Roles of Wind Stress and Subsurface Cold Water in the Second-Year Cooling of the 2017/18 La Niña Event - Licheng Feng; Rong-Hua Zhang; Bo Yu; Xue Han (Advances in Atmospheric Sciences, 2020)

Habitat fragmentation changes top‐down and bottom‐up controls of food webs - Rong Wang; Xin Zhang; Yi‐Su Shi; Yuan‐Yuan Li; Jianguo Wu; Fangliang He; Xiao‐Yong Chen (Ecology, 2020)
Top‐down and bottom‐up controls regulate the structure and stability of ecosystems, but their relative roles in terrestrial systems have been debated. Here we studied a hydro‐inundated land‐bridge system in subtropical China and tested the relative importance of these two controls in determining the rodent‐mediated regeneration of a locally dominant tree species. Our results showed that both controls operated in terrestrial habitats and that their relative importance switched as habitat size changed. Habitat loss initially removed predators of rodents that released rodent populations and triggered massive seed predation (top‐down control), leading to reduced seedling establishment. A further reduction in habitat size led to decrease in rodent population that was supposed to increase seedling survival of the tree species, but the decline in habitat size deteriorated the abiotic environments (bottom‐up control) that severely prevented seedling recruitment. As the ongoing global land use change is creating increasing number of small‐sized forest fragments, our findings provide novel insights into the restoration of seriously fragmented forests.

Comparative transcriptome analysis reveals a gene expression profile that contributes to rhizome swelling in Panax japonicus var. major - Jun Rong Tang; Ying Chun Lu; Zheng Jie Gao; Wan Ling Song; Kun Hua Wei; Yan Zhao; Qing Yan Tang; Xue Jiao Li; Jun Wen Chen; Guang Hui Zhang; Guang Qiang Long; Wei Fan; et al. (Plant Biosystems, 2020)

Genotoxins exaggerate the stressed state of aneuploid embryonic stem cells via activation of autophagy - Meili Zhang; Rong Xiao; Guang Liu; Yue Huang (Science China Life Sciences, 2020)

GaHD1, a candidate gene for the Gossypium arboreum SMA-4 mutant, promotes trichome and fiber initiation by cellular H2O2 and Ca2+ signals - Mingquan Ding; Yuefen Cao; Shae He; Jian Sun; Huaqin Dai; Hua Zhang; Chendong Sun; Yurong Jiang; Andrew H. Paterson; Junkang Rong (Plant Molecular Biology, 2020)

A Novel Eyes Topical Drug Delivery System: CsA-LNC for the Treatment of DED - Anan Zhang; Rong Sun; Meixin Ran; Yaxin Deng; Ying Ge; Yunjing Zhu; Xiumei Tao; Lixia Shang; Jingxin Gou; Haibing He; Tian Yin; Yanjiao Wang; et al. (Pharmaceutical Research, 2020)

Correlation Between CCG Polymorphisms and CAG Repeats During Germline Transmission in Chinese Patients with Huntington’s Disease - Hong-Rong Cheng; Xiao-Yan Li; Hui-Li Yu; Miao Xu; Yan-Bin Zhang; Shi-Rui Gan; Hong-Lei Li; Zhi-Ying Wu (Neuroscience Bulletin, 2020)

Genetic diversity analysis for narrow-leafed lupin (Lupinus angustifolius L.) by SSR markers - Yishan Ji; Rong Liu; Jinguo Hu; Yuning Huang; Dong Wang; Guan Li; Md. Mosiur Rahman; Hongyan Zhang; Chenyu Wang; Mengwei Li; Tao Yang; Xuxiao Zong (Molecular Biology Reports, 2020)

Ferulic Acid Ameliorates MPP+/MPTP-Induced Oxidative Stress via ERK1/2-Dependent Nrf2 Activation: Translational Implications for Parkinson Disease Treatment - Xu Li; Jing Zhang; Hua Rong; Xiaojie Zhang; Miaoxian Dong (Molecular Neurobiology, 2020)

Identification of Ala2Thr mutation in insulin gene from a Chinese MODY10 family - Juan Zhang; Yanjun Liu; Ming Li; Xiaoxu Ge; Ying Wang; Xin Huang; Di Yang; Rong Zhang; Yating Chen; Ming Lu; Jun Yin; Mingqiang Song; et al. (Molecular and Cellular Biochemistry, 2020)

A review of progress in coupled ocean-atmosphere model developments for ENSO studies in China - Rong-Hua Zhang; Yongqiang Yu; Zhenya Song; Hong-Li Ren; Youmin Tang; Fangli Qiao; Tongwen Wu; Chuan Gao; Junya Hu; Feng Tian; Yuchao Zhu; Lin Chen; et al. (Journal of Oceanology and Limnology, 2020)

Circular RNA hsa_circ_0002052 promotes osteosarcoma via modulating miR-382/STX6 axis - Ping-rong Zhang; Jing Ren; Jian-shan Wan; Rong Sun; Ying Li (Human Cell, 2020)

GDP: an open-source GNSS data preprocessing toolkit - Zhengsheng Chen; Yang Cui; Linyang Li; Qinghua Zhang; Zhiping Lu; Xuerui Li; Yingcai Kuang; Kaichun Yang; Fengjuan Rong (GPS Solutions, 2020)

Farm animals and aquaculture: significant reservoirs of mobile colistin resistance genes - Yingbo Shen; Rong Zhang; Stefan Schwarz; Congming Wu; Jianzhong Shen; Timothy R. Walsh; Yang Wang (Environmental Microbiology, 2020)
Summary Colistin resistance has attracted substantial attention after colistin was considered as a last‐resort drug for the treatment of infections caused by carbapenem‐resistant and/or multidrug‐resistant (MDR) Gram‐negative bacteria in clinical settings. However, with the discovery of highly mobile colistin resistance ( mcr ) genes, colistin resistance has become an increasingly urgent issue worldwide. Despite many reviews, which summarized the prevalence, mechanisms, and structures of these genes in bacteria of human and animal origin, studies on the prevalence of mobile colistin resistance genes in aquaculture and their transmission between animals and humans remain scarce. Herein, we review recent reports on the prevalence of colistin resistance genes in animals, especially wildlife and aquaculture, and their possibility of transmission to humans via the food chain. This review also gives some insights into the routine surveillance, changing policy and replacement of polymyxins by polymyxin derivatives, molecular inhibitors, and traditional Chinese medicine to tackle colistin resistance.

Microalgae for saline wastewater treatment: a critical review - Hoang Nhat Phong Vo; Huu Hao Ngo; Wenshan Guo; Soon Woong Chang; Dinh Duc Nguyen; Zhuo Chen; Xiaochang C. Wang; Rong Chen; Xinbo Zhang (Critical Reviews in Environmental Science and Technology, 2020)

A study on the effects of salinity and pH on PSII function in mulberry seedling leaves under saline–alkali mixed stress - Zhang Huihui; Li Xin; Che Yan-hui; Wang Yue; Li Ma-bo; Yang Rong-yi; Xu Nan; Sun Guang-yu (Trees, 2020)

Effect of expanded shrub litter on decomposition of graminoid litter in a temperate freshwater marsh - Xinhou Zhang; Yiping Wang; Wei Jiang; Rong Mao (Plant and Soil, 2020)

Characterization of Pingliang xiaoheidou (ZDD 11047), a soybean variety with resistance to soybean cyst nematode Heterodera glycines - Wei Guo; Jing S. Chen; Feng Zhang; Ze Y. Li; Hai F. Chen; Chan J. Zhang; Li M. Chen; Song L. Yuan; Rong Li; Dong Cao; Qing N. Hao; Shui L. Chen; et al. (Plant Molecular Biology, 2020)

Synthesis, pharmacological evaluation and molecular docking of novel R-/S-2-(2-hydroxypropanamido)-5-trifluoromethyl benzoic acid as dual anti-inflammatory anti-platelet aggregation agents - Rong Rong; Rui-zhen Zhang; Xin Wang; Yu-han Dan; Yun-li Zhao; Zhi-guo Yu (Naunyn-Schmiedeberg's Archives of Pharmacology, 2020)

CU06-1004 (endothelial dysfunction blocker) ameliorates astrocyte end-feet swelling by stabilizing endothelial cell junctions in cerebral ischemia/reperfusion injury - Dong Young Kim; Haiying Zhang; Songyi Park; Yeaji Kim; Cho-Rong Bae; Young-Myeong Kim; Young-Guen Kwon (Journal of Molecular Medicine, 2020)
Cerebral ischemia, or stroke, is widespread leading cause of death and disability. Surgical and pharmacological interventions that recover blood flow are the most effective treatment strategies for stroke patients. However, restoring the blood supply is accompanied by severe reperfusion injury, with edema and astrocyte end-feet disruption. Here, we report that the oral administration of CU06-1004 (previously Sac-1004), immediately after onset of ischemia/reperfusion (I/R), ameliorated cerebral damage. CU06-1004 stabilized blood‑brain barrier by inhibiting the disruption of the tight junction-related protein zona occludens-1 and the cortical actin ring in endothelial cells (ECs) after I/R. Interestingly, CU06-1004 significantly suppressed astrocyte end-feet swelling following I/R, by reducing aquaporin 4 and connexin 43 levels, which mediates swelling. Furthermore, the degradation of β1-integrin and β-dystroglycan, which anchors to the cortical actin ring in ECs, was inhibited by CU06-1004 administration after I/R. Consistently, CU06-1004 administration following I/R also suppressed the loss of laminin and collagen type IV, which bind to the cortical actin ring anchoring proteins. Unlike the protective effects of CU06-1004 in ECs, astrocyte viability and proliferation were not directly affected. Taken together, our observations suggest that CU06-1004 inhibits I/R-induced cerebral edema and astrocyte end-feet swelling by maintaining EC junction stability. Key messages • CU06-1004 ameliorates I/R-induced cerebral injury. • EC junction integrity was stabilized by CU06-1004 treatment after I/R. • CU06-1004 reduces astrocyte end-feet swelling following I/R. • EC junction stability affects astrocyte end-feet structure maintenance after I/R.

The isolation and culture of giant panda (Ailuropoda melanoleuca) breast milk cells - Chen Yijiao; Wang Donghui; Liu Yuliang; Li Feiping; He Ping; Cai Zhigang; Zhang Hao; Chen Min; Hou Rong; An Junhui (In Vitro Cellular & Developmental Biology - Animal, 2020)

Sugar transporter genes in grass carp (Ctenopharyngodon idellus): molecular cloning, characterization, and expression in response to different stocking densities - Xiao Liang; Fengying Yan; Yu Gao; Mei Xiong; Haishan Wang; Kommaly Onxayvieng; Rong Tang; Li Li; Xi Zhang; Wei Chi; Marina Piria; Mirna Mrkonjić Fuka; et al. (Fish Physiology and Biochemistry, 2020)

Effects of streptozotocin on pancreatic islet β-cell apoptosis and glucose metabolism in zebrafish larvae - Xue Wang; Xue-liang Yang; Ke-chun Liu; Wen-long Sheng; Qing Xia; Rong-chun Wang; Xi-qiang Chen; Yun Zhang (Fish Physiology and Biochemistry, 2020)

Separating freshwater flux effects on ENSO in a hybrid coupled model of the tropical Pacific - Chuan Gao; Rong-Hua Zhang; Kristopher B. Karnauskas; Lei Zhang; Feng Tian (Climate Dynamics, 2020)

Central autonomic network functional connectivity: correlation with baroreflex function and cardiovascular variability in older adults - Kan Ding; Takashi Tarumi; Ciwen Wang; Steven Vernino; Rong Zhang; David C. Zhu (Brain Structure and Function, 2020)

Molecular evolution of GII.P17-GII.17 norovirus associated with sporadic acute gastroenteritis cases during 2013–2018 in Zhoushan Islands, China - Can Chen; Bing Wu; Hui Zhang; Ke-Feng Li; Rong Liu; Hong-Ling Wang; Jian-Bo Yan (Virus Genes, 2020)

Simulation of the landform change process on a purple soil slope due to tillage erosion and water erosion using UAV technology - Chao Yang; Zheng-an Su; Jian-rong Fan; Hai-dong Fang; Liang-tao Shi; Jian-hui Zhang; Zhou-yao He; Tao Zhou; Xiao-yi Wang (Journal of Mountain Science, 2020)

Responses of Cloud-Radiative Forcing to Strong El Niño Events over the Western Pacific Warm Pool as Simulated by CAMS-CSM - Baichao Zhang; Zhun Guo; Xiaolong Chen; Tianjun Zhou; Xinyao Rong; Jian Li (Journal of Meteorological Research, 2020)

High resolution UPLC-MS/MS method for simultaneous separation and determination of six flavonoids from semen cuscutae extract in rat plasma: application to comparative pharmacokinetic studies in normal and kidney-deficient rats - Wei Zhang; Zhi-Tian Fu; Yao Xie; Zhi-Wen Duan; Yu Wang; Rong-Hua Fan (Natural Product Research, 2020)

Iridoid, phenylethanoid and flavonoid glycosides from Forsythia suspensa - Qian Wei; Rong Zhang; Qin Wang; Xin Jia Yan; Quan Wei Yu; Fu Xia Yan; Chang Li; Yue Hu Pei (Natural Product Research, 2020)

Transcript profiling of genes involved in carotenoid biosynthesis among three carrot cultivars with various taproot colors - Ya-Hui Wang; Tong Li; Rong-Rong Zhang; Ahmed Khadr; Yong-Sheng Tian; Zhi-Sheng Xu; Ai-Sheng Xiong (Protoplasma, 2020)

Physiological and proteomic responses of mangrove plant Avicennia marina seedlings to simulated periodical inundation - Huan Li; Zan Li; Zhi-Jun Shen; Mei-Rong Luo; Yi-Ling Liu; Ming-Yue Wei; Wen-Hua Wang; Ying-Ying Qin; Chang-Hao Gao; Ke-Ke Li; Qian-Su Ding; Shan Zhang; et al. (Plant and Soil, 2020)

Representing surface wind stress response to mesoscale SST perturbations in western coast of South America using Tikhonov regularization method - Chaoran Cui; Rong-Hua Zhang; Hongna Wang; Yanzhou Wei (Journal of Oceanology and Limnology, 2020)

MiR-145 alleviates Hcy-induced VSMC proliferation, migration, and phenotypic switch through repression of the PI3K/Akt/mTOR pathway - Minghao Zhang; Fan Li; Xiuyu Wang; Jian Gong; Yushan Xian; Guan Wang; Zihan Zheng; Chenxu Shang; Bo Wang; Yanhao He; Weirong Wang; Rong Lin (Histochemistry and Cell Biology, 2020)

Effects of dietary proline on growth, physiology, biochemistry and TOR pathway-related gene expression in juvenile spotted drum Nibea diacanthus - Hua Rong; Fan Lin; Yunlong Zhang; Jun Yu; Chuanqi Yu; Haoran Zhang; Jude Juventus Aweya; Xiaobo Wen (Fisheries Science, 2020)

The Diversity of Associated Microorganisms in Different Organs and Rhizospheric Soil of Arctium lappa L. - Yanping Xing; Yanyun Yang; Liang Xu; Ning Hao; Rong Zhao; Jiahao Wang; Shengnan Li; Dachuan Zhang; Tingting Zhang; Tingguo Kang (Current Microbiology, 2020)

Composition and functional diversity of fecal bacterial community of wild boar, commercial pig and domestic native pig as revealed by 16S rRNA gene sequencing - Jinqing Huang; Wenjuan Zhang; Rong Fan; Zhanggen Liu; Tao Huang; Junyi Li; Tonghao Du; Tao Xiong (Archives of Microbiology, 2020)

The effects of mesoscale oceanographic structures and ambient conditions on the catch of albacore tuna in the South Pacific longline fishery - Cheng Zhou; Pingguo He; Liuxiong Xu; Pascal Bach; Xuefang Wang; Rong Wan; Hao Tang; Yu Zhang (Fisheries Oceanography, 2020)
Albacore tuna ( Thunnus alalunga ) exhibit patchy concentrations associated with biological process at a wide range of spatial scales, resulting in variations in their catchability by fishing gears. Here, we investigated the association of catch variation for pelagic longlines in the South Pacific Ocean with oceanographic mesoscale structures (in horizontal dimension) and ambient conditions (in vertical dimension). The distribution of albacore tuna as indicated by catch per unit effort (CPUE) of longlines was significantly related to the presence of mesoscale structures, with higher CPUE found at locations closer to thermal fronts and with greater gradient magnitudes, as well as areas marked by peripheral contour line of the anticyclone indicated by Sea Surface Height Anomalies ~0.05 m. Surface mesoscale current velocity had the negative effect on the catch, probably as a result of decreased catchability by shoaling the hook depth. Vertical distribution of albacore in the survey region of South Pacific Ocean was hardly restricted by ambient temperature and oxygen concentration, though effect of ambient temperature was relevant and showed a negatively linear correlation with CPUE at the range of 20–24°C. On the contrary, albacore distribution was evidently dominated by the water depth and showed strong preference on water depth of 200 m, which was likely a representative feeding layer. The presence of prey resources and their accessibility by albacore revealed by mesoscale structures in the biological and physical processes, and catchability determined by the location of the baited hooks comprehensively contribute to the variability of catch.

Toonapolyynes A–D, new polyynes from Toona ciliata - Rong Wang; Fu-Qiang Ni; Jun Sang; Yao Zhang; Jia-Luo Huang; Sheng Yin; Gui-Hua Tang (Natural Product Research, 2020)

Simulating Spatial Variation of Soil Carbon Content in the Yellow River Delta: Comparative Analysis of Two Artificial Neural Network Models - Chen Wang; Yuan Cui; Ziwen Ma; Yutong Guo; Qian Wang; Yujiao Xiu; Rong Xiao; Mingxiang Zhang (Wetlands, 2020)

Immunogenicity noninferiority study of 2 doses and 3 doses of an Escherichia coli-produced HPV bivalent vaccine in girls vs. 3 doses in young women - Yue-Mei Hu; Meng Guo; Chang-Gui Li; Kai Chu; Wen-Gang He; Jing Zhang; Jian-Xiang Gu; Juan Li; Hui Zhao; Xiang-Hong Wu; BiZhen Lin; Zhi-Jie Lin; et al. (Science China Life Sciences, 2020)

Polymer-coated urea effects on maize yield and nitrogen losses for hilly land of southern China - Yong Xie; Li Tang; Lan Yang; Yuping Zhang; Haixing Song; Chang Tian; Xiangmin Rong; Yongliang Han (Nutrient Cycling in Agroecosystems, 2020)

Estradiol regulates the expression of CD45 splicing isoforms in lymphocytes - Tianwei Zhang; Zhaoxia Dong; Haitao Cai; Ju Rong; Zhongjing Su (Molecular Biology Reports, 2020)

Reduced mineral fertilization coupled with straw return in field mesocosm vegetable cultivation helps to coordinate greenhouse gas emissions and vegetable production - Rong Huang; Jiang Liu; Xinhua He; Deti Xie; Jiupai Ni; Chang Xu; Yarong Zhang; En Ci; Zifang Wang; Ming Gao (Journal of Soils and Sediments, 2020)

Photoprotection capacity of microalgae improved by regulating the antenna size of light-harvesting complexes - Guang-Rong Hu; Yong Fan; Yan-Lin Zheng; Feng Xu; Lei Zhang; Fu-Li Li (Journal of Applied Phycology, 2020)

Cell membrane damage induced by continuous stress of artemisinin sustained-release microspheres (ASMs) on Microcystis aeruginosa at different physiological stages - Lixiao Ni; Feifei Yue; Jianhua Zhang; Shiyi Rong; Xuanyu Liu; Yifei Wang; Peifang Wang; Danye Li; Na Wang; Hanqi Wu; Shiyin Li (Environmental Science and Pollution Research, 2020)

Evidence of compliance with and effectiveness of guidelines for noninvasive prenatal testing in China: a retrospective study of 189,809 cases - Chan Tian; Tao Deng; Xiuhuang Zhu; Chen Gong; Yangyu Zhao; Yuan Wei; Rong Li; Xiufeng Xu; Miaonan He; Zhiwei Zhang; Jing Cheng; Mol BenWillem; et al. (Science China Life Sciences, 2020)

Atorvastatin ameliorates depressive behaviors and neuroinflammatory in streptozotocin-induced diabetic mice - Zhang Hai-Na; Yu Xu-Ben; Tang Cong-Rong; Cao Yan-Cheng; Yang Fan; Xu Lei-Mei; Sun Ruo-Lan; Ye-Zi; Wang Ye-Xuan; Liang Jing (Psychopharmacology, 2020)

The Monitoring of the Pollution Degree of Maize Under Copper Stress - Chao Zhang; Keming Yang; Kunpeng Rong; Feng Cheng; Yan Li (Journal of the Indian Society of Remote Sensing, 2020)

Effect of different seasons (spring vs summer) on the microbiota diversity in the feces of dairy cows - Han Li; Rong Li; Huijun Chen; Jing Gao; Yu Wang; Yifeng Zhang; Zhili Qi (International Journal of Biometeorology, 2020)

Comparative profiling of roots small RNA expression and corresponding gene ontology and pathway analyses for low- and high-cadmium–accumulating genotypes of wheat in response to cadmium stress - Min Zhou; Shigang Zheng; Yunfang Li; Rong Liu; Lei Zhang; Yu Wu (Functional & Integrative Genomics, 2020)

Seismic resistance of locking ball devices and optimal design for irregular continuous bridges with one fixed pier - Rong Fang; Wenxue Zhang; Shitong Chen; Hanqing Zhao (Bulletin of Earthquake Engineering, 2020)

Effect of woody plant expansion on decomposition of fine root mixtures in a grass-dominated temperate wetland - Xinhou Zhang; Liping Shan; Wenwen Tan; Rong Mao (Wetlands Ecology and Management, 2020)

Steroidogenic acute regulatory protein/aldosterone synthase mediates angiotensin II-induced cardiac fibrosis and hypertrophy - Wei-Wei Zhang; Rong-Hua Zheng; Feng Bai; Katelyn Sturdivant; Ning-Ping Wang; Erskine A. James; Himangshu S. Bose; Zhi-Qing Zhao (Molecular Biology Reports, 2020)

Utilization of pre-existing competent and barren quartz veins as hosts to later orogenic gold ores at Huangjindong gold deposit, Jiangnan Orogen, southern China - Liang Zhang; David I. Groves; Li-Qiang Yang; Si-Chen Sun; Roberto F. Weinberg; Jiu-Yi Wang; Sheng-Gang Wu; Lei Gao; Lan-Ling Yuan; Rong-Hua Li (Mineralium Deposita, 2020)

Analysis of nicotine-induced metabolic changes in Blakeslea trispora by GC-MS - Yang Liu; You-ran Shao; Xiang-yu Li; Zhi-ming Wang; Li-rong Yang; Yu-zhou Zhang; Mian-bin Wu; Jian-ming Yao (Journal of Zhejiang University-SCIENCE B, 2020)

Developing stripe rust resistant wheat (Triticum aestivum L.) lines with gene pyramiding strategy and marker-assisted selection - Rong Liu; Jing Lu; Min Zhou; Shigang Zheng; Zehou Liu; Chihong Zhang; Mei Du; Minxiu Wang; Yunfang Li; Yu Wu; Lei Zhang (Genetic Resources and Crop Evolution, 2020)

Characterization and diagnostic marker development for Yr28-rga1 conferring stripe rust resistance in wheat - Shigang Zheng; Yu Wu; Min Zhou; Lian Zeng; Rong Liu; Yunfang Li; Zehou Liu; Chihong Zhang; Lu Lu; Lei Zhang (European Journal of Plant Pathology, 2020)

Development of Climate and Earth System Models in China: Past Achievements and New CMIP6 Results - Tianjun Zhou; Ziming Chen; Liwei Zou; Xiaolong Chen; Yongqiang Yu; Bin Wang; Qing Bao; Ying Bao; Jian Cao; Bian He; Shuai Hu; Lijuan Li; et al. (Journal of Meteorological Research, 2020)

Stable Isotope Signatures and Moisture Transport of a Typical Heavy Precipitation Case in the Southern Tianshan Mountains - Liwei Wang; Mingjun Zhang; Shengjie Wang; Athanassios A. Argiriou; Gaofei Wang; Vasileios Salamalikis; Mengyu Shi; Rong Jiao (Chinese Geographical Science, 2020)

Sky islands as foci for divergence of fig trees and their pollinators in southwest China - Jun‐Yin Deng; Rong‐Hua Fu; Stephen G. Compton; Mei Liu; Qin Wang; Chuan Yuan; Lu‐Shui Zhang; Yan Chen (Molecular Ecology, 2020)
The dynamics of populations and their divergence over time have shaped current levels of biodiversity and in the case of the “sky islands” of mountainous southwest (SW) China have resulted in an area of exceptional botanical diversity. Ficus tikoua is a prostrate fig tree subendemic to the area that displays unique intraspecific diversity, producing figs typical of different pollination modes in different parts of its range. By combining climate models, genetic variation in populations of the tree's obligate fig wasp pollinators and distributions of the different plant phenotypes, we examined how this unusual situation may have developed. We identified three genetically distinct groups of a single Ceratosolen pollinator species that have largely parapatric distributions. The complex topography of the region contributed to genetic divergence among the pollinators by facilitating geographical isolation and providing refugia. Migration along elevations in response to climate oscillations further enhanced genetic differentiation of the three pollinator groups. Their distributions loosely correspond to the distributions of the functionally significant morphological differences in the male figs of their host plants, but postglacial expansion of one group has not been matched by spread of its associated plant phenotype, possibly due to a major river barrier. The results highlight how interplay between the complex topography of the “sky island” complex and climate change has shaped intraspecies differentiation and relationships between the plant and its pollinator. Similar processes may explain the exceptional botanical diversity of SW China.

Agrobacterium-mediated genetic transformation of Chinese chestnut (Castanea mollissima Blume) - Zhi-lin Sun; Xiao Li; Wan Zhou; Jun-di Yan; Yue-rong Gao; Xiao-wei Li; Jia-chen Sun; Ke-feng Fang; Qing Zhang; Yu Xing; Ling Qin; Qing-qin Cao (Plant Cell, Tissue and Organ Culture (PCTOC), 2020)
Chinese chestnut ( Castanea mollissima ) is an important germplasm resource for the breeding of Castanea species worldwide with vital ecological and economic value. Biotechnology overcomes the limitations of traditional breeding and accelerates germplasm improvement. However, a genetic transformation system for Chinese chestnut has not yet been established. In this study, a stable and efficient Agrobacterium -mediated genetic transformation method for Chinese chestnut is described. Embryogenic calli of C. mollissima cv. ‘Yanshanhongli’ were used as the target material. The sensitivity of embryogenic calli to kanamycin was determined, whereby the proliferation of non-transformed calli was completely inhibited at 180 mg/L. Antibiotic inhibition results for Chinese chestnut embryogenic calli showed that 50 mg/L cefotaxime and 500 μM timentin completely inhibited the growth of Agrobacterium tumefaciens but did not affect the normal growth of Chinese chestnut embryogenic calli. When embryogenic calli were co-cultured for 2 days with Agrobacterium tumefaciens strain AGL1 harboring the PBI121-EGFP plasmid, an embryogenic callus transformation efficiency of 4.55% was obtained, and two transgenic chimera were acquired. This Agrobacterium -mediated transformation system for Chinese chestnut provides a fundamental platform for genetic improvement of core germplasm and for further verification of gene function.

Preferential insertion of a Ty1 LTR-retrotransposon into the A sub-genome’s HD1 gene significantly correlated with the reduction in stem trichomes of tetraploid cotton - Mengling Tang; Xingcheng Wu; Yuefen Cao; Yuan Qin; Mingquan Ding; Yurong Jiang; Chengdong Sun; Hua Zhang; Andrew H. Paterson; Junkang Rong (Molecular Genetics and Genomics, 2020)

Toxicity and metabolism of 3-bromopyruvate in Caenorhabditis elegans - Qiao-ling Gu; Yan Zhang; Xi-mei Fu; Zhao-lian Lu; Yao Yu; Gen Chen; Rong Ma; Wei Kou; Yong-mei Lan (Journal of Zhejiang University-SCIENCE B, 2020)

Spectral Characteristics and the Study of Pollution Degree of Maize Leaves Under Copper and Lead Stress - Chao Zhang; Keming Yang; Yan Li; Feng Cheng; Kunpeng Rong (Journal of the Indian Society of Remote Sensing, 2020)

Effects of shallow groundwater table fluctuations on nitrogen in the groundwater and soil profile in the nearshore vegetable fields of Erhai Lake, southwest China - Dan Zhang; Maopan Fan; Hongbin Liu; Rong Wang; Jixia Zhao; Yanxian Yang; Rongyang Cui; Anqiang Chen (Journal of Soils and Sediments, 2020)

The effects of climate change and groundwater exploitation on the spatial and temporal variations of heavy metal content in maize in the Luan River catchment of China - Rong Ma; Bin Zhang; Xiaoni Zhou (Environmental Science and Pollution Research, 2020)

Prenatal exposure to organophosphate pesticides, maternal paraoxonase 1 genotype, and childhood neurodevelopment at 24 months of age in Shandong, China - Yiwen Wang; Yan Zhang; Lin Ji; Yijun Zhou; Rong Shi; Michihiro Kamijima; Jun Ueyama; Yu Gao; Ying Tian (Environmental Science and Pollution Research, 2020)

Antler stem cells as a novel stem cell source for reducing liver fibrosis - Xiaoli Rong; Yanyan Yang; Guokun Zhang; Haiying Zhang; Chunyi Li; Yimin Wang (Cell and Tissue Research, 2020)
Liver fibrosis results from collagen fiber deposition. Antler stem cells (ASCs) naturally in vivo differentiate into cartilage, which is only made of Col II in collagen component; whereas liver fibrosis is caused by over-abundance of Col I and III. In addition, ASCs can effectively promote regenerative wound healing in which tissue contains very few collagen fibers (Col I). In this study, we investigate the therapeutic effects of ASCs in a rat model of CCl 4 -induced liver fibrosis. Rats were treated with ASCs for 4 weeks in vivo, then biochemical and histopathological analyses were performed. Furthermore, we established cell co-culture systems of hepatic stellate cells (HSCs) and ASCs and of M1 macrophages and ASCs in vitro. Mesenchymal stem cells (MSCs) were used as a positive control. The results showed that ASC transplantation alleviated liver fibrosis effectively as evidenced by reduced collagen accumulation, decreased fatty degeneration, increased hepatocyte regeneration, decreased inflammation and significantly enhanced liver function; moreover, ASCs decreased the expression of pro-fibrogenic factors including TGF-β and α-SMA. Additionally, our study showed that ASCs inhibit HSC activation and proliferation by controlling the expression of MMPs, TIMP1, TGF-β, α-SMA and COL1A2 involved in these processes. Our results suggested that ASCs alleviate liver fibrosis effectively and inhibit HSC activation. Thus, ASCs may serve as a novel stem cell source for the treatment of liver fibrosis in the clinic.

Three functional variants were identified to affect RPS24 expression and significantly associated with risk of colorectal cancer - Danyi Zou; Hongli Zhang; Juntao Ke; Jiaoyuan Li; Ying Zhu; Yajie Gong; Yang Yang; Jianbo Tian; Yi Zhang; Xiating Peng; Kailin Cai; Rong Zhong; et al. (Archives of Toxicology, 2020)

Preparation and In vitro Evaluation of FDM 3D-Printed Ellipsoid-Shaped Gastric Floating Tablets with Low Infill Percentages - Di Chen; Xiang-Yu Xu; Rui Li; Gen-Ao Zang; Yue Zhang; Ming-Rui Wang; Meng-Fei Xiong; Jia-Rui Xu; Ting Wang; Hui Fu; Qin Hu; Bin Wu; et al. (AAPS PharmSciTech, 2020)

One bis-indole alkaloid-voacamine from Voacanga africana Stapf: biological activity evaluation of PTP1B in vitro utilizing enzymology method based on SPRi expriment - Yan-Qiu Wang; Hong-Xiang Li; Xiao-Chun Liu; Jin-Shuang Zhao; Rong-Qiang Liu; Wen-ying Huai; Wei-Jun Ding; Tian-E Zhang; Yun Deng (Natural Product Research, 2019)

Zizania aquatica–duck ecosystem with recycled biogas slurry maintained crop yield - Guiliang Wang; Jianghong Zhang; Xiangming Kou; Shouhong Wang; Jianfeng Liu; Rong Xu; Guangming Han; Leiming Wu; Lingyu Zhu (Nutrient Cycling in Agroecosystems, 2019)

Molecular cloning and characterization of genes related to the ethylene signal transduction pathway in pomegranate (Punica granatum L.) under different temperature treatments - Rong Huang; Wei Li; Xiao-Wan Guan; Biao Xie; Shui-Ming Zhang (Journal of Biosciences, 2019)

Effects of dietary hydroxyproline on collagen metabolism, proline 4-hydroxylase activity, and expression of related gene in swim bladder of juvenile Nibea diacanthus - Hua Rong; Yunlong Zhang; Meilin Hao; Weiguang Zou; Jun Yu; Chuanqi Yu; Qinchao Shi; Xiaobo Wen (Fish Physiology and Biochemistry, 2019)

Paramyxoviruses respiratory syncytial virus, parainfluenza virus, and human metapneumovirus infection in pediatric hospitalized patients and climate correlation in a subtropical region of southern China: a 7-year survey - Wen-Kuan Liu; De-Hui Chen; Wei-Ping Tan; Shu-Yan Qiu; Duo Xu; Li Zhang; Shu-Jun Gu; Rong Zhou; Qian Liu (European Journal of Clinical Microbiology & Infectious Diseases, 2019)

Interception of sulfate deposition from a closed canopy to a forest gap edge canopy in a subalpine dragon spruce plantation - Yu Zhang; Fu-zhong Wu; Bo Tan; Zhen-feng Xu; Han Li; Jun-cheng Liu; Hai-rong Zhao; Si-yi Tan; Cheng-ming You; Wan-qin Yang (Journal of Mountain Science, 2019)

Effects of Different Preservation Methods on Physicochemical Property of Marine Pathogen Vibrio anguillarum - Yongxiang Yu; Zheng Zhang; Yingeng Wang; Meijie Liao; Xiaojun Rong; Bin Li; Hao Zhang (Journal of Ocean University of China, 2019)

Interaction Between Planetary Boundary Layer and PM2.5 Pollution in Megacities in China: a Review - Yucong Miao; Jing Li; Shiguang Miao; Huizheng Che; Yaqiang Wang; Xiaoye Zhang; Rong Zhu; Shuhua Liu (Current Pollution Reports, 2019)
Purpose of Review During the past decades, the number and size of megacities have been growing dramatically in China. Most of Chinese megacities are suffering from heavy PM 2.5 pollution. In the pollution formation, the planetary boundary layer (PBL) plays an important role. This review is aimed at presenting the current state of understanding of the PBL-PM 2.5 interaction in megacities, as well as to identify the main gaps in current knowledge and further research needs. Recent Findings The PBL is critical to the formation of urban PM 2.5 pollution at multiple temporal scales, ranging from diurnal change to seasonal variation. For the essential PBL structure/process in pollution, the coastal megacities have different concerns from the mountainous or land-locked megacities. In the coastal cities, the recirculation induced by sea-land breeze can accumulate pollutants, whereas in the valley/basin, the blocking effects of terrains can lead to stagnant conditions and thermal inversion. Within a megacity, although the urbanization-induced land use change can cause thermodynamic perturbations and facilitate the development of PBL, the increases in emissions outweigh this impact, resulting in a net increase of aerosol concentration. Moreover, the aerosol radiative effects can modify the PBL by heating the upper layers and reducing the surface heat flux, suppressing the PBL and exacerbating the pollution. Summary This review presented the PBL-PM 2.5 interaction in 13 Chinese megacities with various geographic conditions and elucidated the critical influencing processes. To further understand the complicated interactions, long-term observations of meteorology and aerosol properties with multi-layers in the PBL need to be implemented.

The complete chloroplast genome of the daimyo oak, Quercus dentata Thunb. - Hua-Lei Hu; Jing-Yu Zhang; Yu-Ping Li; Lu Xie; Dong-Bin Chen; Qun Li; Yan-Qun Liu; Shu-Rong Hui; Li Qin (Conservation Genetics Resources, 2019)

Impact of CYP2R1, CYP27A1 and CYP27B1 genetic polymorphisms controlling vitamin D metabolism on susceptibility to hepatitis C virus infection in a high-risk Chinese population - Jing-jing Yang; Hao-zhi Fan; Ting Tian; Meng-ping Wu; Chao-nan Xie; Peng Huang; Rong-bin Yu; Hong-Gang Yi; Yun Zhang; Jie Wang (Archives of Virology, 2019)

The Optimal Precursors for ENSO Events Depicted Using the Gradient-definition-based Method in an Intermediate Coupled Model - Bin Mu; Juhui Ren; Shijin Yuan; Rong-Hua Zhang; Lei Chen; Chuan Gao (Advances in Atmospheric Sciences, 2019)

Downscaling climate change of mean climatology and extremes of precipitation and temperature: Application to a Mediterranean climate basin - Rong Zhang; João Corte‐Real; Madalena Moreira; Chris Kilsby; Aidan Burton; Hayley J. Fowler; Stephen Blenkinsop; Stephen Birkinshaw; Nathan Forsythe; João P. Nunes; Elsa Sampaio (International Journal of Climatology, 2019)
Downscaling is usually necessary for robust hydrological impact assessments. This may be undertaken using a wide range of methods, including a combination of dynamical and statistical‐stochastic downscaling. This study uses the Spatial–Temporal Neyman‐Scott Rectangular Pulses model—RainSimV3, the precipitation‐conditioned daily weather generator—ICAAM‐WG, and the change factor approach for downscaling synthetic climate scenarios for robust hydrological impact assessment at middle‐sized basins. The ICAAM‐WG was developed based on the concept of the Climate Research Unit daily weather generator (CRU‐WG), motivated by the need for improved representation of heat waves by downscaling methods given the positive feedback between low soil moisture and high air temperature. We demonstrated the validity of the proposed methodology in the 705‐km 2 Mediterranean climate basin in southern Portugal. The results show that, for the control period 1980–2010, both RainSimV3 and ICAAM‐WG reproduced not only the mean climatology, but also extreme wet and low precipitation events, as well as the extremes of temperature and heat waves. We found that downscaling with ICAAM‐WG (SIM6), which uses second‐order autoregressive processes for the simulation of temperature during consecutive dry and wet days, outperformed ICAAM‐WG (SIM4), which used only first‐order autoregressive processes, leading to improved simulation of heat waves. ICAAM‐WG (SIM6) well reproduced observed heatwave extremes with return periods of up to 30 years; however, ICAAM‐WG (SIM4) overestimated these extremes substantially. This indicates the importance of incorporating second‐order autoregressive processes in the simulation of heatwave length. In the context of climate warming, the proposed methodology provides a tool to improve downscaled projections of future extremes with confidence intervals for not only wet events but also dry spells and heat waves.

Root diversity in sesame (Sesamum indicum L.): insights into the morphological, anatomical and gene expression profiles - Ruqi Su; Rong Zhou; Marie Ali Mmadi; Donghua Li; Lu Qin; Aili Liu; Jianqiang Wang; Yuan Gao; Mengyuan Wei; Lisong Shi; Ziming Wu; Jun You; et al. (Planta, 2019)

Combined gastroscopic and choledochoscopic transabdominal nasobiliary drainage - Song-mei Lou; Min Zhang; Zheng-rong Wu; Gui-xing Jiang; Hua Shen; Yi Dai; Yue-long Liang; Li-ping Cao; Guo-ping Ding (Journal of Zhejiang University-SCIENCE B, 2019)

METTL1 overexpression is correlated with poor prognosis and promotes hepatocellular carcinoma via PTEN - Qiu-Hong Tian; Mei-Fang Zhang; Jin-Sheng Zeng; Rong-Guang Luo; Yang Wen; Jun Chen; Liu-Gen Gan; Jian-Ping Xiong (Journal of Molecular Medicine, 2019)

Observed structural relationships between ocean chlorophyll variability and its heating effects on the ENSO - Rong-Hua Zhang; Feng Tian; Hai Zhi; Xianbiao Kang (Climate Dynamics, 2019)

Synergistic effects of stromal cell-derived factor-1α and bone morphogenetic protein-2 treatment on odontogenic differentiation of human stem cells from apical papilla cultured in the VitroGel 3D system - Min Xiao; Jun Qiu; Rong Kuang; Beidi Zhang; Wei Wang; Qing Yu (Cell and Tissue Research, 2019)

Urinary Metal Concentrations and the Incidence of Hypertension Among Adult Residents Along the Yangtze River, China - Qi Zhong; Chun-xiao Jiang; Chi Zhang; Qian Zhang; Qi-rong Qin; Xiao-dong Wang; Fen Huang (Archives of Environmental Contamination and Toxicology, 2019)

Network parameters quantify loss of assemblage structure in human‐impacted lake ecosystems - Rong Wang; John A. Dearing; C. Patrick Doncaster; Xiangdong Yang; Enlou Zhang; Peter G. Langdon; Hui Yang; Xuhui Dong; Zhujun Hu; Min Xu; Yanjie Zhao; Ji Shen (Global Change Biology, 2019)
Lake biodiversity is an incomplete indicator of exogenous forcing insofar as it ignores underlying deformations of community structure. Here, we seek a proxy for deformation in a network of diatom assemblages comprising 452 species in 273 lakes across China. We test predictions from network theory that nodes of similar type will tend to self‐organize in an unstressed system to a positively skewed frequency distribution of nodal degree. The empirical data reveal shifts in the frequency distributions of species associations across regions, from positive skew in lakes in west China with a history of low human impacts, to predominantly negative skew amongst lakes in highly disturbed regions in east China. Skew values relate strongly to nutrient loading from agricultural activity and urbanization, as measured by total phosphorus in lake water. Reconstructions through time show that positive skew reduces with temporal intensification of human impacts in the lake and surrounding catchments, and rises as lakes recover from disturbance. Our study illustrates how network parameters can track the loss of aquatic assemblage structure in lakes associated with human pressures.