Process and applications of alginate oligosaccharides with emphasis on health beneficial perspectives - Chunhua Zhang; Mingxi Li; Abdur Rauf; Anees Ahmed Khalil; Zhiguo Shan; Chuying Chen; Kannan R. R. Rengasamy; Chunpeng Wan (Critical Reviews in Food Science and Nutrition, 2023)

Sources, distribution and decomposition of soil organic matter based on an effective biomarker in the pastoral areas of Zoige Plateau, China - Bin Wang; Tingqian Shan; Junjie Wang; Fuyang Huang; Wei Liu; Weiguo Tu; Sen Li; Qingsong Chen (Chemosphere, 2023)

Co-existence effect of copper oxide nanoparticles and ciprofloxacin on simultaneous nitrification, endogenous denitrification, and phosphorus removal by aerobic granular sludge - Yu-Qi Li; Bai-Hang Zhao; Xiao-Tang Chen; Yu-Qing Zhang; Hai-Shan Yang (Chemosphere, 2023)

Highly efficient in-situ cleaner degradation of difenoconazole by two novel dominant strains: Microflora diversity, monoclonal isolation, growth factor optimization, intermediates, and pathways - Xiaoxin Chen; Shan Peng; Miao Liu; Lei Wang; Kyongjin Pang; Liyuan Zhang; Ziyi Cui; An Liu (Chemosphere, 2023)

Establishment of the first cell line from the small yellow croaker (Larimichthys polyactis) and its application in unraveling the mechanism of ROS-induced apoptosis under hypoxia - Jingqian Wang; Xinming Gao; Li Wang; Chen Du; Congcong Hou; Feng Liu; Qingping Xie; Bao Lou; Shan Jin; Junquan Zhu (Aquaculture, 2023)

A study of the critical velocity and the confinement velocity of fire accident in a longitudinally ventilated underground train with different door opening scenarios - Zhihe Su; Yanfeng Li; Shan Feng; Hua Zhong; Junmei Li; Wenbo Liu; Chao Chen; Jiaxin Li (Tunnelling and Underground Space Technology, 2023)

Seasonal variation and ecological risk assessment of Pharmaceuticals and Personal Care Products (PPCPs) in a typical semi-enclosed bay — The Bohai Bay in northern China - Kun Lin; Rui Wang; Tongzhu Han; Liju Tan; Xue Yang; Mengmeng Wan; Yanshan Chen; Ting Zhao; Shan Jiang; Jiangtao Wang (Science of The Total Environment, 2023)

Toxicity of ceria nanoparticles to the regeneration of freshwater planarian Dugesia japonica: The role of biotransformation - Changjian Xie; Xiaowei Li; Lisha Hei; Yiqing Chen; Yuling Dong; Shujing Zhang; Shan Ma; Jianing Xu; Qiuxiang Pang; Iseult Lynch; Zhiling Guo; Peng Zhang (Science of The Total Environment, 2023)

Synergistic effect of hydrogen and nanoscale zero-valent iron on ex-situ biogas upgrading and acetate recovery - Kai-Kai Wu; Lei Zhao; Zhong-Fang Sun; Zi-Han Wang; Chuan Chen; Hong-Yu Ren; Shan-Shan Yang; Nan-Qi Ren (Science of The Total Environment, 2023)

Banana MaERF124 negatively modulates carotenoid accumulation during fruit ripening through repression of carotenogenesis genes - Danling Cai; Hong Xu; Zongli Liu; Nanhui Chen; Lisha Zhu; Zengxiang Lin; Chaojie Wu; Wei Shan; Jianye Chen; Wangjin Lu; Lin Chen; Jianfei Kuang (Postharvest Biology and Technology, 2023)

Undescribed isoquinolines from Zanthoxylum nitidum and their antiproliferative effects against human cancer cell lines - Feng Qin; Cai Yi Wang; Chun-Gu Wang; Yao Chen; Jin-Jun Li; Mei-Shan Li; Yan-Kui Zhu; Sang Kook Lee; Heng-Shan Wang (Phytochemistry, 2023)

Mid-Miocene uplift and tectonic-sedimentary evolution of the Taiwan accretionary prism: Constraints from sedimentary records in the Hengchun Peninsula, southern Taiwan - Xinchang Zhang; Yi Yan; Yildirim Dilek; Wen-Huang Chen; Yehua Shan (Marine and Petroleum Geology, 2023)

Review on recent progress in on-line monitoring technology for atmospheric pollution source emissions in China - Huanqin Wang; Jitong Zhou; Xue Li; Qiang Ling; Hongyuan Wei; Lei Gao; Ying He; Ming Zhu; Xiao Xiao; Youjiang Liu; Shan Li; Chilai Chen; et al. (Journal of Environmental Sciences, 2023)

Element mobility and Mg isotope fractionation during peridotite serpentinization - Mei-Shan Zhao; Yi-Xiang Chen; Jia-Wei Xiong; Yong-Fei Zheng; Xiang-Ping Zha; Fang Huang (Geochimica et Cosmochimica Acta, 2023)

Superior PbO-resistance of CeO2/ZrO2 catalyst promoted by solid superacid SO42−/ZrO2 for selective catalytic reduction of NO with NH3 - Xiaodi Li; Shan Ren; Lian Liu; Xiangdong Xing; Lin Chen; Jiangling Li; Jian Yang; Qingcai Liu (Fuel, 2023)

Catalytic performance and sulfur resistance of OMS-2 modified by copper for mercury removal at low temperature - Jun Han; Weiwei Shan; Bo Zhao; Yiming Wang; Qiang Zhang; Linbo Qin; Wangsheng Chen (Fuel, 2023)

Study on engineering application method of large-scale reaction mechanism in knock prediction - Hanjun Xu; Jian Wu; Jingsi Wei; Ceyuan Chen; Mingjia Liu; Shan Wu (Fuel, 2023)

Kinetic study for thermocatalytic degradation of waste mixed cloth over antibiotic residue derived carbon-based solid acids - Chengyu Li; Jun Zhang; Rui Shan; Haoran Yuan; Yong Chen (Fuel, 2023)

Assessment soil cadmium and copper toxicity on barley growth and the influencing soil properties in subtropical agricultural soils - Xiaoqing Zhang; Yuanjie Zhu; Zhuangzhuang Li; Jiong Li; Shan Wei; Wangsheng Chen; Dajun Ren; Shuqin Zhang (Environmental Research, 2023)

Heme-oxygenase-1 as a target for phthalate-induced cardiomyocytes ferroptosis - Jia-Xin Wang; Yi Zhao; Ming-Shan Chen; Hao Zhang; Jia-Gen Cui; Jin-Long Li (Environmental Pollution, 2023)

Numerical study on flexural and bond-slip behaviours of GFRP profiled-concrete composite beams with groove shear connector - Wenjie Ge; Zhiwen Zhang; Zhongwei Guan; Ashraf Ashour; Yue Ge; Yiwen Chen; Hongbo Jiang; Chuanzhi Sun; Shan Yao; Weihua Yan; Dafu Cao (Engineering Structures, 2023)

Zincophilic polymer semiconductor as multifunctional protective layer enables Dendrite-Free zinc metal anodes - Jiangmin Jiang; Zhenghui Pan; Jiaren Yuan; Jun Shan; Chenglong Chen; Shaopeng Li; HaiXu; Yaxin Chen; Quanchao Zhuang; Zhicheng Ju; Hui Dou; Xiaogang Zhang; et al. (Chemical Engineering Journal, 2023)

Near-infrared I/II emission and absorption carbon dots via constructing localized excited/charge transfer state for multiphoton imaging and photothermal therapy - Wen-Bo Zhao; Dan-Dan Chen; Kai-Kai Liu; Yong Wang; Rui Zhou; Shi-Yu Song; Fu-Kui Li; Lai-Zhi Sui; Qing Lou; Lin Hou; Chong-Xin Shan (Chemical Engineering Journal, 2023)

A review on the NOx precursors release during biomass pyrolysis - Hongyuan Chen; Rui Shan; Fengxiao Zhao; Jing Gu; Yuyuan Zhang; Haoran Yuan; Yong Chen (Chemical Engineering Journal, 2023)

Synthesis of amorphous Nickel-Cobalt hydroxides with high areal capacitance by one-step electrodeposition using polymeric additive - Wenxuan Hu; Huakang Fu; Lu Chen; Xing Wu; Biao Geng; Yanling Huang; Yifei Xu; Miao Du; Guorong Shan; Yihu Song; Ziliang Wu; Qiang Zheng (Chemical Engineering Journal, 2023)

Preparation of polyethyleneimine-modified chitosan/Ce-UIO-66 composite hydrogel for the adsorption of methyl orange - Zhi Chen; Zhi-Bo Zhang; Jun Zeng; Zhi-Jie Zhang; Shan Ma; Cong-Ming Tang; Jun-Qiang Xu (Carbohydrate Polymers, 2023)

Effect of alkaline washing treatment on leaching behavior of municipal solid waste incineration bottom ash - Zhen Chen; Jiang-Shan Li; Dongxing Xuan; Chi Sun Poon; Xiao Huang (Environmental Science and Pollution Research, 2023)

Exploration of long afterglow luminescent materials composited with graphitized carbon nitride for photocatalytic degradation of basic fuchsin - Shan-Shan Li; Min Liu; Li Wen; Zhou Xu; Yun-Hui Cheng; Mao-Long Chen (Environmental Science and Pollution Research, 2023)

Self-powered photoelectrochemical aptasensor for sensitive detection of Microcystin-RR by integrating TiO2/S-doped Ti3C2 MXene photoanode and MoS2/S-doped Ti3C2 MXene photocathode - Yude Zhang; Xiaojiao Du; Meng Wei; Xueling Shan; Wenchang Wang; Ding Jiang; Hiroshi Shiigi; Zhidong Chen (Analytica Chimica Acta, 2023)

An assessment of the subduction rate in the CMIP6 historical experiment - Shan Liu; Xueyi Jing; Xingrong Chen; Huijun Wang (Acta Oceanologica Sinica, 2023)

Associations between residential proximity to agricultural land use as pesticides exposure and birth outcomes - Kuna-Chun Chen; Shuo-Fang Lee; Shyang-Woei Lin; Jia-Shan Xie; Yu‐Hsun Chang; Lih-Ming Yiin; Chia-Jung Hsieh (Environmental Science and Pollution Research, 2022)

Mesenchymal Stem Cell Secreted-Extracellular Vesicles are Involved in Chondrocyte Production and Reduce Adipogenesis during Stem Cell Differentiation - Yu-Chen Tsai; Tai-Shan Cheng; Hsiu-Jung Liao; Ming-Hsi Chuang; Hui-Ting Chen; Chun-Hung Chen; Kai-Ling Zhang; Chih-Hung Chang; Po-Cheng Lin; Chi-Ying F. Huang (Tissue Engineering and Regenerative Medicine, 2022)
Background: Extracellular vesicles (EVs) are derived from internal cellular compartments, and have potential as a diagnostic and therapeutic tool in degenerative disease associated with aging. Mesenchymal stem cells (MSCs) have become a promising tool for functional EVs production. This study investigated the efficacy of EVs and its effect on differentiation capacity. Methods: The characteristics of MSCs were evaluated by flow cytometry and stem cell differentiation analysis, and a production mode of functional EVs was scaled from MSCs. The concentration and size of EVs were quantitated by Nanoparticle Tracking Analysis (NTA). Western blot analysis was used to assess the protein expression of exosome-specific markers. The effects of MSC-derived EVs were assessed by chondrogenic and adipogenic differentiation analyses and histological observation. Results: The range of the particle size of adipose-derived stem cells (ADSCs)- and Wharton’s jelly -MSCs-derived EVs were from 130 to 150 nm as measured by NTA, which showed positive expression of exosomal markers. The chondrogenic induction ability was weakened in the absence of EVs in vitro . Interestingly, after EV administration, type II collagen, a major component in the cartilage extracellular matrix, was upregulated compared to the EV-free condition. Moreover, EVs decreased the lipid accumulation rate during adipogenic induction. Conclusion: The results indicated that the production model could facilitate production of effective EVs and further demonstrated the role of MSC-derived EVs in cell differentiation. MSC-derived EVs could be successfully used in cell-free therapy to guide chondrogenic differentiation of ADSC for future clinical applications in cartilage regeneration.

Infrared Radiation and Acoustic Emission of Damage Evolution and Failure Precursory for Water-Bearing Coal - Tiancheng Shan; Zhonghui Li; Xin Zhang; Yue Niu; He Tian; Quancong Zhang; Zesheng Zang; Zhoujie Gu; Chao Cai; Chen Liu (Rock Mechanics and Rock Engineering, 2022)

Detailed numerical modeling for breach hydrograph and morphology evolution during landslide dam breaching - Shengyao Mei; Shengshui Chen; Qiming Zhong; Yibo Shan (Landslides, 2022)

SIRT1-Enriched Exosomes Derived from Bone Marrow Mesenchymal Stromal Cells Alleviate Peripheral Neuropathy via Conserving Mitochondrial Function - Lizhen Shan; Fenfen Zhan; Detao Lin; Fabo Feng; Xinji Chen; Xiaolin Li; Di Yang (Journal of Molecular Neuroscience, 2022)

Combined cadmium and fluorine inhibit lettuce growth through reducing root elongation, photosynthesis, and nutrient absorption - Mei Wang; Zhiqin Chen; Dan Chen; Lei Liu; Yasir Hamid; Shijun Zhang; Anqi Shan; Kyong Ju Kang; Ying Feng; Xiaoe Yang (Environmental Science and Pollution Research, 2022)

Effects of cadmium (Cd) on fungal richness, diversity, and community structure of Haplic Cambisols and inference of resistant fungal genera - Na Luo; Xiajie Zhang; Shan Chen; Haixia Wang; Ding Liu; Jinfeng Song (Environmental Science and Pollution Research, 2022)

MiR-139-5p/ENAH Affects Progression of Hepatocellular Carcinoma Cells - Yueming Zhang; Meng Li; Yinghuan Qiu; Yuhua Wu; Shan Chen; Bin Ni; Ding Tang; Zhouzi Deng; Zhiqiang Hu (Biochemical Genetics, 2022)

Detailed seafloor geomorphology of the western region of the North Yellow Sea, China: The result of Holocene erosional and depositional processes sculpting the offshore continental shelf - Xiaoyu Liu; Yilan Chen; Chenguang Liu; Qiuhua Tang; Yanhong Wang; Shan Gao (Acta Oceanologica Sinica, 2022)

Environmental DNA metabarcoding reveals the biological community structure in Poyang Lake, China - Chunhua Zhou; Jinping Chen; Ting Guo; Shan Ouyang; Xiaoping Wu (Conservation Genetics Resources, 2022)

Associations of single and multiple organophosphate pesticide exposure with female infertility in the USA: data from the 2015–2018 National Health and Nutrition Examination Survey - Yingying Wu; Xueqiong Weng; Shan Liu; Yuxuan Tan; Huanzhu Liang; Yexin Li; Lin Wen; Qian Chen; Chunxia Jing (Environmental Science and Pollution Research, 2022)

Release of Endogenous Brain-derived Neurotrophic Factor into the Lateral Entorhinal Cortex from the Paraventricular Thalamus Ameliorates Social Memory Deficits in a Mouse Model of Alzheimer’s Disease - Yun-Long Xu; Lin Zhu; Zi-Jun Chen; Xiao-Fei Deng; Pei-Dong Liu; Shan Li; Bing-Chun Lin; Chuan-Zhong Yang; Wei Xu; Kui-Kui Zhou; Ying-Jie Zhu (Neuroscience Bulletin, 2022)

Genomic prediction of drought tolerance during seedling stage in maize using low-cost molecular markers - Ao Zhang; Shan Chen; Zhenhai Cui; Yubo Liu; Yuan Guan; Shuang Yang; Jingtao Qu; Juchao Nie; Dongdong Dang; Cong Li; Xiaomei Dong; Jinjuan Fan; et al. (Euphytica, 2022)
Drought tolerance in maize is a complex and polygenic trait, especially in the seedling stage. In plant breeding, complex genetic traits can be improved by genomic selection (GS), which has become a practical and effective breeding tool. In the present study, a natural maize population named Northeast China core population (NCCP) consisting of 379 inbred lines were genotyped with diversity arrays technology (DArT) and genotyping-by-sequencing (GBS) platforms. Target traits of seedling emergence rate (ER), seedling plant height (SPH), and grain yield (GY) were evaluated under two natural drought stress environments in northeast China. Adequate genetic variations were observed for all the target traits, but they were divergent across environments. Similarly, the heritability of the target trait also varied across years and environments, the heritabilities in 2019 (0.88, 0.82, 0.85 for ER, SPH, GY) were higher than those in 2020 (0.65, 0.53, 0.33) and cross-2-years (0.32, 0.26, 0.33). In total, three marker datasets, 11,865 SilicoDArT markers obtained from the DArT-seq platform, 7837 SNPs obtained from the DArT-seq platform, and 91,003 SNPs obtained from the GBS platform, were used for GS analysis after quality control. The results of phylogenetic trees showed that broad genetic diversity existed in the NCCP population. Genomic prediction results showed that the average prediction accuracies estimated using the DArT SNP dataset under the two-fold cross-validation scheme were 0.27, 0.19, and 0.33, for ER, SPH, and GY, respectively. The result of SilicoDArT is close to the SNPs from DArT-seq, those were 0.26, 0.22, and 0.33. For the trait with lower heritability, the prediction accuracy can be improved using the dataset filtered by linkage disequilibrium. For the same trait, the prediction accuracies estimated with two DArT marker datasets were consistently higher than that estimated with the GBS SNP dataset under the same genotyping cost. The prediction accuracy was improved by controlling population structure and marker quality, even though the marker density was reduced. The prediction accuracies were improved by more than 30% using the significant-associated SNPs. Due to the complexity of drought tolerance under the natural stress environments, multiple years of data need to be accumulated to improve prediction accuracy by reducing genotype-by-environment interaction. Modeling genotype-by-environment interaction into genomic prediction needs to be further developed for improving drought tolerance in maize. The results obtained from the present study provides valuable pathway for improving drought tolerance in maize using GS.

Numerical analysis of pile—slope stability and the soil arching around two adjacent piles - Chien-Yuan Chen; Chun-Kai Chang; Yu-Shan Lin (Journal of Mountain Science, 2022)

CFD-FEM Simulation of Slamming Loads on Wedge Structure with Stiffeners Considering Hydroelasticity Effects - Zhenwei Chen; Jialong Jiao; Qiang Wang; Shan Wang (Journal of Marine Science and Engineering, 2022)
In this paper, both numerical and experimental methods are adopted to study the fluid–structure interaction (FSI) problem of a wedge structure with stiffeners impacted with water during the free-falling water entry process. In the numerical model, a partitioned two-way couple of CFD and FEM solvers is applied to deal with the FSI problem, where the external fluid pressure exported from the CFD simulation is used to derive the structural responses in the FEM solver, and the structural deformations are fed back into the CFD solver to deform the mesh. Moreover, a tank experiment using a steel wedge model that has the same structural properties is also conducted to compare with the numerical results. Verification and validation of the numerical results indicate that the CFD-FEM coupled method is feasible and reliable. The slamming response results by numerical simulation and experiments, including displacement, velocity, acceleration, slamming pressure, deformation, structural stresses and total forces on the wedge, accounting for hydroelasticity effects in different free falling height conditions are comprehensively analyzed and discussed.

Associations between short-term exposure to ambient PM2.5 and incident cases of cerebrovascular disease in Yantai, China - Junyan Liu; Maobo Wang; Yang Zhao; Haotian Chen; Haiyun Liu; Baoshun Yang; Haifeng Shan; Hongyu Li; Yukun Shi; Luyang Wang; Guangcheng Wang; Chunlei Han (Environmental Science and Pollution Research, 2022)

Long-term changes in the spatio-temporal distribution of snailfish Liparis tanakae in the Yellow Sea under fishing and environmental changes - Yunlong Chen; Xiujuan Shan; Qingpeng Han; Harry Gorfine; Fangqun Dai; Xianshi Jin (Frontiers in Marine Science, 2022)
Tanaka’s snailfish ( Liparis tanakae ) is a low-economic but ecologically important fish in the Yellow Sea, which is one of the most threatened marine ecosystems in the world due to environmental changes and human activities. Although it serves as both a dominant species and an apex predator, our knowledge about the long-term changes in the spatio-temporal distribution of this snailfish remains limited in the threatened ecosystem. In this study, by developing eight alternative vector autoregressive spatio-temporal (VAST) models including various combinations of sea surface temperature (SST), fishing pressure (FP) and the density of the prey (DP), we investigated the spatio-temporal distribution patterns of snailfish based on fishery-independent surveys conducted between 2003 and 2019 and examined the relative importance of different covariates. We found that SST was the most important factor in explaining variation in encounter probability and DP was the most important factor in explaining temporal variation in biomass density of snailfish. Surprisingly, incorporation of FP in the spatio-temporal models neither improved explanation of the variance in encounter probability nor biomass density. Based on Akaike’s information criterion, we selected a spatio-temporal model with SST in preference to seven alternative models. The inter-annual distribution range of snailfish was relatively stable whereas the spatial patterns varied over time. In 2003–2006 and 2011, the hotspots of snailfish were widely distributed throughout almost the entire Yellow Sea area. In contrast, in other survey years, especially in 2007–2009, 2015–2016 and 2019, the distribution was more concentrated within the central Yellow Sea. No significant shift in centers of gravity (COGs) was detected for the population. The estimated effective area occupied correlated significantly with biomass density of snailfish ( r = -0.71, P< 0.05). Outputs from this study enhanced our understanding of how and the extent to which multiple pressures influence the observed long-term changes in spatio-temporal distribution of snailfish in the Yellow Sea.

Toxicological effects of fipronil on laying hens and its residue elimination in eggs - Qiaoyan Zhang; Xiajun Wang; Qiang Wang; Dake Qi; Yali Huang; Riping Chen; Ying Shan; Weihuan Fang (Environmental Science and Pollution Research, 2022)

Mesenchymal Stem Cells Alleviate Inflammatory Bowel Disease Via Tr1 Cells - Lingli Qi; Jing Wu; Shan Zhu; Xue Wang; Xinping Lv; Chunyan Liu; Yong-Jun Liu; Jingtao Chen (Stem Cell Reviews and Reports, 2022)

Epigallocatechin-3-Gallate Pretreatment Improves Autologous Adipose-derived Stem Cells Against Rheumatoid Arthritis-induced Neuroinflammation in the Brain of Collagen-induced Rats - Ming-Shan Chen; Bruce Chi-Kang Tsai; Maria Angelina Sitorus; Chia-Hua Kuo; Wei-Wen Kuo; Tung-Sheng Chen; Chien-Yao Fu; Tsung-Jung Ho; Chih-Yang Huang; Da-Tong Ju (Neurotoxicity Research, 2022)

Characterizing diversity based on phenotypes and molecular marker analyses of purple yam (Dioscorea alata L.) germplasm in southern China - Xin Chen; Jingyu Sun; Qianglong Zhu; Yao Xiao; Hongyu Zhang; Yingjin Huang; Putao Wang; Tianxu Cao; Rui Hu; Zijin Xiang; Nan Shan; Qinghong Zhou (Genetic Resources and Crop Evolution, 2022)

Clinical profiles and antimicrobial resistance patterns of invasive Salmonella infections in children in China - Wen Song; Qingwen Shan; Yue Qiu; Xianyao Lin; Chunhui Zhu; Zhiqiang Zhuo; Caihong Wang; Jianning Tong; Rui Li; Chaomin Wan; Yu Zhu; Minxia Chen; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2022)
Invasive Salmonella infections result in a significant burden of disease including morbidity, mortality, and financial cost in many countries. Besides typhoid fever, the clinical impact of non-typhoid Salmonella infections is increasingly recognized with the improvement of laboratory detection capacity and techniques. A retrospective multicenter study was conducted to analyze the clinical profiles and antimicrobial resistance patterns of invasive Salmonella infections in hospitalized children in China during 2016–2018. A total of 130 children with invasive Salmonella infections were included with the median age of 12 months (range: 1–144 months). Seventy-nine percent of cases occurred between May and October. Pneumonia was the most common comorbidity in 33 (25.4%) patients. Meningitis and septic arthritis caused by nontyphoidal Salmonella (NTS) infections occurred in 12 (9.2%) patients and 5 (3.8%) patients. Patients < 12 months (OR: 16.04) and with septic shock (OR: 23.4), vomit (OR: 13.33), convulsion (OR: 15.86), C-reactive protein (CRP) ≥ 40 g/L (OR: 5.56), and a higher level of procalcitonin (PCT) (OR: 1.05) on admission were statistically associated to an increased risk of developing meningitis. Compared to 114 patients with NTS infections , 16 patients with typhoid fever presented with higher levels of CRP and PCT ( P < 0.05). The rates of resistance to ampicillin, sulfamethoxazole/trimethoprim, ciprofloxacin, and ceftriaxone among Salmonella Typhi and NTS isolates were 50% vs 57.3%, 9.1% vs 24.8%, 0% vs 11.2%, and 0% vs 9.9%, respectively. NTS has been the major cause of invasive Salmonella infections in Chinese children and can result in severe diseases. Antimicrobial resistance among NTS was more common.

Relationship between urinary dichlorophenols and cognitive function among people over 60 years old from NHANES - Xueqiong Weng; Huanzhu Liang; Kun Liu; Jingmin Chen; Qiaoyuan Fei; Shan Liu; Xinrong Guo; Lin Wen; Yingying Wu; Zhiqiang Nie; Chunxia Jing (Environmental Science and Pollution Research, 2022)

Influences of human waste–based ectopic fermentation bed fillers on the soil properties and growth of Chinese pakchoi - Jiabin Li; Xue Liu; Changxiong Zhu; Liangguo Luo; Zhuobo Chen; Shan Jin; Bing Geng (Environmental Science and Pollution Research, 2022)

Starch, cellulose and plant extracts as green inhibitors of metal corrosion: a review - Li Huang; Wei-Qiang Chen; Shan-Shan Wang; Qing Zhao; Hui-Jing Li; Yan-Chao Wu (Environmental Chemistry Letters, 2022)

Sestrin2 attenuates renal damage by regulating Hippo pathway in diabetic nephropathy - Yawei Bian; Chonglin Shi; Shan Song; Lin Mu; Ming Wu; Duojun Qiu; Jiajia Dong; Wei Zhang; Chen Yuan; Dongyun Wang; Zihui Zhou; Xuan Dong; et al. (Cell and Tissue Research, 2022)

LIC color texture enhancement algorithm for ocean vector field data based on HSV color mapping and cumulative distribution function - Hongbo Zheng; Qin Shao; Jie Chen; Yangyang Shan; Xujia Qin; Ji Ma; Xiaogang Xu (Acta Oceanologica Sinica, 2022)

Fishing for fish environmental DNA: Ecological applications, methodological considerations, surveying designs, and ways forward - Meng Yao; Shan Zhang; Qi Lu; Xiaoyu Chen; Si‐Yu Zhang; Yueqiao Kong; Jindong Zhao (Molecular Ecology, 2022)
Vast global declines of freshwater and marine fish diversity and population abundance pose serious threats to both ecosystem sustainability and human livelihoods. Environmental DNA (eDNA)‐based biomonitoring provides robust, efficient, and cost‐effective assessment of species occurrences and population trends in diverse aquatic environments. Thus, it holds great potential for improving conventional surveillance frameworks to facilitate fish conservation and fisheries management. However, the many technical considerations and rapid developments underway in the eDNA arena can overwhelm researchers and practitioners new to the field. Here, we systematically analysed 416 fish eDNA studies to summarize research trends in terms of investigated targets, research aims, and study systems, and reviewed the applications, rationales, methodological considerations, and limitations of eDNA methods with an emphasis on fish and fisheries research. We highlighted how eDNA technology may advance our knowledge of fish behaviour, species distributions, population genetics, community structures, and ecological interactions. We also synthesized the current knowledge of several important methodological concerns, including the qualitative and quantitative power eDNA has to recover fish biodiversity and abundance, and the spatial and temporal representations of eDNA with respect to its sources. To facilitate ecological applications implementing fish eDNA techniques, recent literature was summarized to generate guidelines for effective sampling in lentic, lotic, and marine habitats. Finally, we identified current gaps and limitations, and pointed out newly emerging research avenues for fish eDNA. As methodological optimization and standardization improve, eDNA technology should revolutionize fish monitoring and promote biodiversity conservation and fisheries management that transcends geographic and temporal boundaries.

Improving language model of human genome for DNA–protein binding prediction based on task-specific pre-training - Hanyu Luo; Wenyu Shan; Cheng Chen; Pingjian Ding; Lingyun Luo (Interdisciplinary Sciences: Computational Life Sciences, 2022)

Interactive effects of water management and liming on CH4 emissions and rice cadmium uptake in an acid paddy soil - Yong Wang; Yanni Sun; Le Chen; Hua Shao; Yanhua Zeng; Yongjun Zeng; Feiyu Tang; Junhuo Cai; Shan Huang (Environmental Science and Pollution Research, 2022)

Discovery of immunosuppressive Lupane-type Triterpenoids from Hypericum longistylum - Shan Yan; Hao Feng; Lingjuan Sun; Zhengyi Shi; Hong Hu; Yulin Duan; Yi Guo; Xiaosheng Tan; Gang Chen; Changxing Qi; Yonghui Zhang (Natural Product Research, 2022)

Contact toxicity and repellence of essential oil from Senecio scandens and its major components against three stored product insects - Fang He; Jing-Yu Liu; Li-Jiang Chen; Zi-Qian Cheng; Meng-Qi Cheng; Shu-Shan Du; Yu-Li Sang; Yan-Jun Hao (Natural Product Research, 2022)

Shallow-water hydrothermal vent system as an extreme proxy for discovery of microbiome significance in a crustacean holobiont - Ling Chiu; Min-Chen Wang; Kuang-Yu Tseng; Chih-Lin Wei; Huei-Ting Lin; Shan-Hua Yang; Yung-Che Tseng (Frontiers in Marine Science, 2022)
The shallow-water hydrothermal vent (HV) system off Kueishan Island lies at the end of the Okinawa Trough to the northeast of Taiwan. Near its submarine vent openings, aperiodic vent discharges generate a dynamic acidic (pH 5.5-8.1) and sulfidic (9-3000 μM) ecosystem. The dominant metazoan in this unique environment is the brachyuran vent crab, Xenograpsus testudinatus , which has developed robust metabolic strategies and highly adaptive acid-base regulatory mechanisms to maintain its physiological homeostasis. X. testudinatus is considered a holobiont, but the symbiotic mechanisms underlying acid and sulfur tolerance in the host-microbe system remain largely unclear. In this study, we used LoopSeq long-read sequencing of the full-length 16S rRNA gene to identify the bacterial communities present in the gills and carapace surface of X. testudinatus . The alpha diversity analysis, Venn diagram, and principal coordinate analysis (PCoA) indicated that the gills and carapace surface exhibit different bacterial constituents. Further measurements of relative abundance, coupled with functional predictions and fluorescence in situ hybridization (FISH), revealed a predominance of Sulfurovum sp. NBC37-1, a key bacterium that can perform sulfur and hydrogen oxidation to support denitrification processes. Consequently, our findings suggest that the symbiotic bacteria may play a critical role in conferring the extraordinary acid and sulfur tolerances of X. testudinatus , allowing the crustacean holobiont to thrive in its ecological niche within one of the most extreme marine habitats on Earth.

The MAP-Kinase HOG1 Controls Cold Adaptation in Rhodosporidium kratochvilovae by Promoting Biosynthesis of Polyunsaturated Fatty Acids and Glycerol - Wei Chen; Xiaoqing Zhang; Shan Li; Jinjin Cui; Xiaoxia Yang; Qi Zhang (Current Microbiology, 2022)

An enhanced method for estimating snow water equivalent in the central part of the Tibetan Plateau using raster segmentation and eigenvector spatial filtering regression model - Qi-shan Cheng; Yu-min Chen; Jia-xin Yang; Yue-jun Chen; Zhe-xin Xiong; An-nan Zhou (Journal of Mountain Science, 2022)

Exploiting the gut microbiota to predict the origins and quality traits of cultured sea cucumbers - Zelong Zhao; Jingwei Jiang; Jie Zheng; Yongjia Pan; Ying Dong; Zhong Chen; Shan Gao; Yao Xiao; Pingzhe Jiang; Xuda Wang; Gaohua Zhang; Bai Wang; et al. (Environmental Microbiology, 2022)
Summary Nowadays, the true economic and nutritional value of food is underpinned by both origin and quality traits, more often expressed as increased quality benefits derived from the origin source. Gut microbiota contribute to food metabolism and host health, therefore, it may be suitable as a qualifying indicator of origin and quality of economic species. Here, we investigated relationships between the gut microbiota of the sea cucumber ( Apostichopus japonicus ), a valuable aquaculture species in Asia, with their origins and quality metrics. Based on data from 287 intestinal samples, we generated the first biogeographical patterns for A . japonicus gut microbiota from origins across China. Importantly, A . japonicus origins were predicted using the random forest model that was constructed using 20 key gut bacterial genera, with 97.6% accuracy. Furthermore, quality traits such as saponin, fat and taurine were also successfully predicted by random forest models based on gut microbiota, with approximately 80% consistency between predicted and true values. We showed that substantial variations existed in the gut microbiota and quality variables in A . japonicus across different origins, and we also demonstrated the great potential of gut microbiota to track A . japonicus origins and predict their quality traits.

A mini-review: mechanism of antimicrobial action and application of surfactin - Xiaoyu Chen; Yajun Lu; Mengyuan Shan; Hongyuan Zhao; Zhaoxin Lu; Yingjian Lu (World Journal of Microbiology and Biotechnology, 2022)

Human Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorate Skin Aging of Nude Mice Through Autophagy-Mediated Anti-Senescent Mechanism - Ting Li; Li Zhou; Mengqiang Fan; Zuxiang Chen; Li Yan; Haishan Lu; Ming Jia; Huiling Wu; Letian Shan (Stem Cell Reviews and Reports, 2022)

Nanoscale storage encryption: data storage in synthetic DNA using a cryptosystem with a neural network - Yue Teng; Shan Yang; Liyan Liu; Ruicun Liu; Yaofeng Chen; Jinyu Li; Qian Yang; Tuoyu Liu; Yujun Cui; Peng Cheng; Shengqi Wang (Science China Life Sciences, 2022)

History of suicide attempts associated with the thinning right superior temporal gyrus among individuals with schizophrenia - Yi Yin; Jinghui Tong; Junchao Huang; Baopeng Tian; Song Chen; Shuping Tan; Zhiren Wang; Fude Yang; Yongsheng Tong; Fengmei Fan; Peter Kochunov; Neda Jahanshad; et al. (Brain Imaging and Behavior, 2022)

Influence of nitrogen wet deposition on nitrogen output in a typical watershed in the Three Gorges Reservoir Area - Chen-dong Lu; Liu-yi Zhang; Kun Yan; Yu-kuan Wang; Shan-gao Xiong; Chen-tao Huang; Ting-zhen Li; Mao-fei Ni (Journal of Mountain Science, 2022)

Expression Characteristics and Putative Functions of KIF3A/KIF3B During Spermiogenesis of Phascolosoma esculenta - Chen Du; Danli Mu; Xinming Gao; Shengyu Luo; Jianping Wang; Shan Jin; Junquan Zhu (Journal of Ocean University of China, 2022)

ML323, a USP1 inhibitor triggers cell cycle arrest, apoptosis and autophagy in esophageal squamous cell carcinoma cells - Yaxin Sun; Beibei Sha; Wenjing Huang; Miaomiao Li; Shan Zhao; Yuan Zhang; Jie Yan; Zheng Li; Jingwen Tang; Peiyan Duan; Jianxiang Shi; Pei Li; et al. (Apoptosis, 2022)

Variations in nutrients and microbes during the occurrence and extinction of algal blooms: A mesocosm experiment with the addition of marine aquaculture sediment - Yuanmin Sun; Kunxian Tang; Yong Ma; Xuan Zhu; Heyang Li; Fei Zhang; Shan Chen; Haiping Huang (Frontiers in Marine Science, 2022)
The release of pollutants in sediment often causes secondary pollution of seawater. In this paper, marine aquaculture sediment was added to seawater in a coastal land–based mesocosm, and the changes in microbial and physicochemical parameters were measured to study the influence of sediment disturbance on seawater. The results showed that sediment disturbance had adverse effects on seawater. After adding and stirring the aquaculture sediment, the concentration of dissolved oxygen (DO) gradually decreased, and those of nutrients gradually increased; in particular, the concentrations of ammonia and dissolved inorganic phosphorus (DIP) increased most sharply. After day 9, a bloom dominated by Chaetoceros occurred. Concentrations of chlorophyll a (Chl-a) increased, and two obvious Chl-a peaks were observed; the trends of DO and pH were similar to that of Chl-a during the bloom period; and DIP and ammonia were exhausted during periods of Chl-a peaks. During the extinction of algal blooms, the concentrations of Chl-a and DO decreased, whereas those of DIP and ammonia increased. The variation trends of bacteria and viruses were similar to that of Chl-a, with two obvious peaks, which were later than those of Chl-a. There were close connections between Chl-a and nutrients, bacteria and viruses and they showed a trend of changes in turn from nutrients to phytoplankton to bacteria to viruses during the experiment. We concluded that bloom formation was mainly affected by nutrients and weather, and the main reason for bloom decline was the depletion of nutrients. The increase in zooplankton, bacteria, and virus abundance was the ecological effect after the occurrence of algal blooms, and they affected the development of algal blooms.

The transcription factor HcERF4 confers salt and drought tolerance in kenaf (Hibiscus cannabinus L.) - Jiao Yue; Meiqiong Tang; Hui Zhang; Dengjie Luo; Shan Cao; Yali Hu; Zhen Huang; Qijing Wu; Xia Wu; Jiao Pan; Canni Chen; Caijin Wang; et al. (Plant Cell, Tissue and Organ Culture (PCTOC), 2022)

Lipofundin mediates major inhibition of intravenous propofol on phorbol myristate acetate and Escherichia coli-induced neutrophil extracellular traps - Ming-Shan Chen; Kung-Ssu Yang; Wen-Chun Lin; Chien-Liang Fang; Hsin-Fu Chen; Shew-Meei Sheu (Molecular Biology Reports, 2022)

Association between secondhand smoke and peripheral arterial disease: a meta-analysis of cross-sectional studies - Chih-Wei Wu; Hung-Yi Chuang; Kazuhiro Watanabe; Pei-Shan Wu; Hui-Chen Pan; Chao-Ling Wang; Chen-Cheng Yang; Chih-Hsing Hung; Chia-Yen Dai; Chi-Kung Ho; Norito Kawakami (International Archives of Occupational and Environmental Health, 2022)

Changes in Distribution Patterns for Larimichthys polyactis in Response to Multiple Pressures in the Bohai Sea Over the Past Four Decades - Qingpeng Han; Xiujuan Shan; Xianshi Jin; Harry Gorfine; Yunlong Chen; Chengcheng Su (Frontiers in Marine Science, 2022)
Understanding patterns of change in the distribution of species among their critical habitats is important for analyzing population dynamics and adaptive responses to environmental shifts. We investigated spatio-temporal changes in small yellow croaker ( Larimichthys polyactis ) using eight alternative models fitted to data from bottom trawl surveys conducted in the Bohai Sea each spring (spawning period) and summer during 1982–2018. These models included different combinations of local sea temperature, fishing pressure, and individual climate index (i.e., North Pacific index, NPI, and West Pacific index, WPI) as explanatory variables. Selection of the most parsimonious model for each season was based on Akaike’s Information Criterion (AIC). The model with NPI as its only explanatory variable was used as a base case for pre-analysis. In spring, a spatio-temporal model with sea temperature as a quadratic effect, plus the spatially varying effects of a climate index and fishing pressure was selected, as the AIC value of this model was reduced by 41.491 compared to the base case model without these effects. In the summer after spawning, the spatio-temporal model with WPI as a climate index covariate lagged by 1-year best explained the spatio-temporal distribution patterns of the stock. The results suggested that small yellow croaker populations significantly decreased in biomass in the Bohai Sea over the study period. A statistically significant northeastward shift in the center of gravity (COG) and a contraction in the distribution range occurred in summer throughout the study period ( p <0.05). During the spring sequence (1993–2018), a statistically significant northeastward shift in the COG was also found ( p <0.05). Our results showed that biomass-density hotspots of small yellow croaker in both seasons have shrunk or disappeared in recent years. Overall, these findings suggest that the spatio-temporal patterns of the populations in their spawning, feeding and nursery grounds have been influenced over the past 40 years by multiple pressures, and population density in the southwestern areas of the Bohai Sea declined faster and more drastically than in the northeastern areas. This study has important implications for developing targeted spatial conservation measures for small yellow croaker at various stages of its life history under different levels of stress.

Effects of Mixing and Stratification on the Vertical Distribution and Size Spectrum of Zooplankton on the Shelf and Slope of the Northern South China Sea - Kaixuan Chen; Meng Zhou; Yisen Zhong; Joanna J. Waniek; Congwen Shan; Zhaoru Zhang (Frontiers in Marine Science, 2022)
The northern shelf and off-shelf regions of the South China Sea (SCS) present a stark contrast between being eutrophic from terrestrial runoffs of nutrients and biota and being oligotrophic with multiple nutrient limitations due to the distance to land sources and stable permanent stratification. The abundance, size, and trophic structures of plankton in the shelf and off-shelf regions were studied in a joint Sino-German cruise conducted between September 1 and 24, 2018. A laser optical plankton counter was mounted on a water sampler-CTD (conductivity–temperature–depth) system for studying the horizontal and vertical distributions of plankton structures in a size range between 0.1 and 35 mm and their relationships with hydrographic and biological features in the northern SCS and its shelf region. Results revealed the subsurface chlorophyll maximum layer (SCM) below the pycnocline and plankton aggregation near the SCM about a depth of 50–60 m. The distributions of small plankton between 0.1 and 0.5 mm were strongly correlated with stratification and SCM compared to those of large plankton. Analyzing the intercept and slope of a normalized biovolume spectrum (NBVS) as an indicator for abundance and size structure of a plankton community, results revealed that in the shelf region, the slopes exhibited no significant vertical variations in the water column regardless of stratification and SCM. In contrast, in the off-shelf stratified water column, the intercepts and slopes were lower and flatter in the surface layer, higher and steeper in the SCM layer, and the lowest and flattest in the deep layer. Stirring by the typhoon also altered both the abundances and size structures of the plankton communities, with significant regional differences. This study elucidates the variances of plankton abundances, distributions, NBVS slopes, and intercepts among different water column structures in both shelf and off-shelf regions of the northern SCS.

The fine mapping of dwarf gene Rht5 in bread wheat and its effects on plant height and main agronomic traits - Chunge Cui; Qiumei Lu; Zhangchen Zhao; Shan Lu; Shan Duan; Yang Yang; Yue Qiao; Liang Chen; Yin-Gang Hu (Planta, 2022)

A Deep Mesencephalic Nucleus Circuit Regulates Licking Behavior - Di Zheng; Jia-Yu Fu; Meng-Yu Tang; Xiao-Dan Yu; Yi Zhu; Chen-Jie Shen; Chun-Yue Li; Shi-Ze Xie; Shan Lin; Minmin Luo; Xiao-Ming Li (Neuroscience Bulletin, 2022)

Development of an empirical model for predicting peak breach flow of landslide dams considering material composition - Yibo Shan; Shengshui Chen; Qiming Zhong; Shengyao Mei; Meng Yang (Landslides, 2022)

Whole Genome Sequencing and Biological Characteristics of Two Strains of Porcine Escherichia coli Isolated from Saba Pigs - Bo Zhang; Weiwei Zhao; Bin Gao; Chunlan Shan; Xi Wang; Quan Wan; Jing Deng; Jinglong Cha; Bingxun Chen; Dongmei Han; Libo Gao; Pingxing Ao; et al. (Current Microbiology, 2022)

Particle breakage and shape analysis of calcareous sand under consolidated-undrained triaxial shear - Jianhua Shen; Xing Wang; Yi Shan; Jie Cui; Xiang Chen; Xinzhi Wang; Changqi Zhu (Bulletin of Engineering Geology and the Environment, 2022)

Photobacterium damselae subsp. damselae in mariculture - Moussa Gouife; Suyang Chen; Kejing Huang; Mateen Nawaz; Shan Jin; Rongrong Ma; Yajun Wang; Liangyi Xue; Jiasong Xie (Aquaculture International, 2022)

The response of ABA and hydraulic indicator-mediated leaf gas exchange and nonstructural carbohydrate of Ginkgo biloba saplings to drought and rehydration - Zhicheng Chen; Chang Liu; Xin Li; Shan Li; Xianchong Wan; Shirong Liu (Acta Physiologiae Plantarum, 2022)

Estimating seasonal habitat suitability for migratory species in the Bohai Sea and Yellow Sea: A case study of Tanaka’s snailfish (Liparis tanakae) - Yunlong Chen; Xiujuan Shan; Dingyong Zeng; Harry Gorfine; Yinfeng Xu; Qiang Wu; Tao Yang; Xianshi Jin (Acta Oceanologica Sinica, 2022)

An adaptive data cleaning framework: a case study of the water quality monitoring system in China - Zeng Chen; Peng Jiang; Jun Liu; Song Zheng; Zhenyu Shan; Zhihua Li; Huan Xu; Igor V. Bychkov; Alexei E. Hmelnov (Hydrological Sciences Journal, 2022)

Metagenomic analysis reveals wide distribution of phototrophic bacteria in hydrothermal vents on the ultraslow-spreading Southwest Indian Ridge - Hong Chen; Deng Hui Li; Ai Jun Jiang; Xue Gong Li; Shi Jun Wu; Jian Wei Chen; Meng Jie Qu; Xiao Qing Qi; Jie Dai; Rui Zhao; Wei-Jia Zhang; Shan Shan Liu; et al. (Marine Life Science & Technology, 2022)

Mixed effects of perfluoroalkyl and polyfluoroalkyl substances exposure on cognitive function among people over 60 years old from NHANES - Xueqiong Weng; Huanzhu Liang; Yuxuan Tan; Jingmin Chen; Qiaoyuan Fei; Shan Liu; Xinrong Guo; Lin Wen; Yingying Wu; Chunxia Jing (Environmental Science and Pollution Research, 2022)

Attribution of the seasonality of atmospheric heating changes over the western tropical Pacific with a focus on the spring season - Shuheng Lin; Song Yang; Shan He; Zhenning Li; Jiaxin Chen; Wenjie Dong; Jiaxue Wu (Climate Dynamics, 2022)
Atmospheric diabatic heating, a major driving force of atmospheric circulation over the tropics, is strongly confined to the tropical western North Pacific (TWNP) region, with the global warmest sea surface temperature (SST). The changes in diabatic heating over the TWNP, which exert great impacts on the global climate system, have recently exhibited a noticeable seasonal dependence with a remarkable increase in boreal spring. In this study, we applied observations, reanalysis data, and numerical experiments to investigate the causes of the seasonality in heating changes. Results show that in boreal spring convection is more sensitive to the TWNP SST, leading to a more significant enhancement of deep convection, although the increase in the SST is nearly the same as that in the other seasons. In the non-spring seasons, the enhanced convection due to increased local SST is suppressed by the anomalous anticyclonic wind shear over the TWNP, generated by the easterly wind anomalies induced by the tropical Indian Ocean (TIO) warming via the Kevin waves. However, the TIO warming does not show any suppressing effect in spring because it is much weaker than that in the other seasons and thus the warming itself cannot induce sufficient convective heating anomalies to excite the Kelvin waves.

Research on the Reduction Performance of Surface Runoff Pollution Through Permeable Pavement with Different Structures - Mulian Zheng; Wang Chen; Qian Gao; Shan Liu; Chaoxian Deng; Yue Ma; Guoqiang Ji (Water, Air, & Soil Pollution, 2022)

Influence of the spatial distribution pattern of buildings on the distribution of PM2.5 concentration - Zhixuan Zhang; Baoyan Shan; Qikai Lin; Yanqiu Chen; Xinwei Yu (Stochastic Environmental Research and Risk Assessment, 2022)

Low-temperature adaptation and preservation revealed by changes in physiological–biochemical characteristics and proteome expression patterns in post-harvest Hami melon during cold storage - Ming Ning; Fengxian Tang; Jiluan Chen; Wen Song; Wenchao Cai; Qin Zhang; Xinxin Zhao; Xinquan Yang; Chunhui Shan; Guangfei Hao (Planta, 2022)

Inhibition of caspase-1 ameliorates tauopathy and rescues cognitive impairment in SAMP8 mice - Meng-Shan Tan; Yi Liu; Hao Hu; Chen-Chen Tan; Lan Tan (Metabolic Brain Disease, 2022)

Liposome-Encapsulated Rec8 and Dmrt1 Plasmids Induce Red-Spotted Grouper (Epinephelus akaara) Testis Maturation - Xuzhuo Duan; Xianze Jia; Kaishan Liang; Fengqi Huang; Jinhong Shan; Huitao Chen; Xinhe Ruan; Lihua Li; Huihong Zhao; Qing Wang (Marine Biotechnology, 2022)

Fine mapping and candidate gene analysis of dwarf gene Rht14 in durum wheat (Triticum durum) - Shan Duan; Chunge Cui; Liang Chen; Zujun Yang; Yin-Gang Hu (Functional & Integrative Genomics, 2022)

Oceanospirillum sediminis sp. nov., Isolated From Coastal Sediment in the Yellow Sea - Huilin Zhao; Yue Tian; Xunke Sun; Qianwen Wu; Si Chen; Jiangfan Shan; Yu Zhong; Xinyu Chen; Xiaoxue Gao; Shengnan Liu; Ruochen Wang; Zongjun Du; et al. (Current Microbiology, 2022)

The impact of Alzheimer's disease susceptibility loci on lateral ventricular surface morphology in older adults - Shan Li; Na An; Nan Chen; Yin Wang; Lin Yang; Yalin Wang; Zhijun Yao; Bin Hu (Brain Structure and Function, 2022)

Identify runoff generation patterns of check dams and terraces and the effects on runoff: a case study - Youqian Chen; Shengqi Jian; Qiang Wu; Caihong Hu; Shan-e-hyder Soomro (Acta Geophysica, 2022)

Physiological and histological responses of Phascolosoma esculenta (Sipuncula: Phascolosomatidea) to acute heat stress - Xinming Gao; Haiyan Yang; Daojun Tang; Chen Du; Shan Jin; Congcong Hou; Chundan Zhang; Junquan Zhu; Jianping Wang (Journal of Oceanology and Limnology, 2022)

Photocatalytic degradation of imidacloprid by optimized Bi2WO6/NH2-MIL-88B(Fe) composite under visible light - Mao-Long Chen; Tian-Hui Lu; Shan-Shan Li; Li Wen; Zhou Xu; Yun-Hui Cheng (Environmental Science and Pollution Research, 2022)

Estimation of Avian Influenza Viruses in Water Environments of Live Poultry Markets in Changsha, China, 2014 to 2018 - Xiaoyu Li; Rusheng Zhang; Zheng Huang; Dong Yao; Lei Luo; Jingfang Chen; Wen Ye; Lingzhi Li; Shan Xiao; Xiaolei Liu; Xinhua Ou; Biancheng Sun; et al. (Food and Environmental Virology, 2022)

Development and characterization of 36 SNP markers for Hynobius yiwuensis - Shuangshuang Shan; Xia Kan; Jie Gong; Chen Shao; Yu Wang (Conservation Genetics Resources, 2022)

Correction to: Hepatitis C virus core protein activates Wnt/β-catenin signaling through multiple regulation of upstream molecules in the SMMC-7721 cell line - Jiao Liu; Zengchan Wang; Jia Tang; Renkuan Tang; Xiaoliang Shan; Wenlu Zhang; Qingmei Chen; Fan Zhou; Ke Chen; Ailong Huang; Ni Tang (Archives of Virology, 2022)

Mitogenomic phylogeny resolves Cuneopsis (Bivalvia: Unionidae) as polyphyletic: The description of two new genera and a new species - Xiao‐Ping Wu; Yu‐Ting Dai; Nan Yin; Feng‐Yue Shu; Zhong‐Guang Chen; Liang Guo; Chun‐Hua Zhou; Shan Ouyang; Xiao‐Chen Huang (Zoologica Scripta, 2022)
Freshwater mussels are known to have two types of mitochondrial DNA (mtDNA) transmitted separately through oocytes and sperms, namely, maternal (F‐type) and paternal (M‐type) mtDNA. The additional suite of mitochondrial genes provides a great opportunity to resolve phylogenetically problematic relationships. East Asian freshwater mussels of the genus Cuneopsis were considered a compact group of taxa having wedge‐shaped shells. However, preliminary results from previous studies challenged the monophyly of Cuneopsis , and the exact phylogenetic relationships among Cuneopsis and its allied genera are yet to be determined with comprehensive species sampling. Here, we evaluated species boundaries in Cuneopsis based on COI barcoding and obtained 11 new F‐ and M‐type mitogenomes via genome skimming to elucidate the evolutionary history of Cuneopsis . COI barcode data supported the validity of all sampled six Cuneopsis species (missing C. kiangsiensis ). Our mitochondrial phylogenomic analyses confirmed that the currently recognized genus Cuneopsis sensu lato was polyphyletic, recovering three well‐supported clades. Molecular dating analysis suggested Cuneopsis s.l . diversified at ~58.06 million years ago in the Paleogene. Hereby, we propose two new genera, that is, Arcuneopsis gen. nov. and Pseudocuneopsis gen. nov. Additionally, we report a new species, Pseudocuneopsis sichuanensis sp. nov., from Chengdu, Sichuan, China, and a newly recorded species from China, Cuneopsis demangei .

Classifications and Characteristics of Marine Heatwaves in the Northern South China Sea - Yinxia Wang; Jisheng Zeng; Zheng Wei; Shan Li; Song Tian; Fan Yang; Qidong Chen; Yinghui He (Frontiers in Marine Science, 2022)
The classifications and associated characteristics of marine heatwaves (MHWs) in the northern South China Sea (SCS) have been investigated. Based on the ratio of the area with MHWs to the total area of the northern SCS, the MHWs are divided into three categories, i.e., narrow coverage, moderate coverage, and wide coverage. Different kinds of MHWs (i.e., narrow coverage, moderate coverage, and wide coverage) contribute around 64, 28, and 8% to the total days with MHWs, respectively. Narrow coverage MHW scatters over the northern SCS continental shelf, and moderate (wide) coverage MHWs are concentrated east of Hainan Island (mid of northern SCS continental shelf). Wide coverage MHWs contribute more than 50% to the total MHW cumulative sea surface temperature (SST) anomalies. The cumulative days and temperature anomalies of all kinds of MHWs exhibit significant long-term trends and decadal variability.

Precision agriculture technology adoption: a qualitative study of small-scale commercial “family farms” located in the North China Plain - Helen Kendall; Beth Clark; Wenjing Li; Shan Jin; Glyn. D. Jones; Jing Chen; James Taylor; Zhenhong Li; Lynn. J. Frewer (Precision Agriculture, 2022)
Precision agriculture (PA) technologies offer a potential solution to food security and environmental challenges but, will only be successful if adopted by farmers. Adoption in China lags behind that in some developed agricultural economies despite scientifically proven benefits of PA technologies for Chinese agriculture. Adoption is dependent on farmer attitudes and perceptions towards PA technologies. An exploratory qualitative study using in-depth interviews was conducted with Chinese arable farmers (n = 27) to explore their perceptions towards and adoption intentions of PA technologies in two Chinese provinces (Hebei and Shandong). A thematic analysis revealed five central themes to have emerged from the data, these were: “socio-political landscape”, “farming culture”, “agricultural challenges”, “adoption intentions (barriers/facilitators” and “practical support mechanisms” . All were likely to influence the level and rate of adoption of PA technologies amongst family farmers in China. The research revealed an openness to the potential of PA technologies amongst family farmers, although there was heterogeneity in the perceptions of PA technology and willingness to adopt. Improved rates of adoption will be achieved by reducing the barriers to adoption, including the need for low-cost PA applications that can be applied at small scale, improved information provision, financial support mechanisms including more accessible subsidies and credit, and reliable, regulated and affordable service provision.

Trimetazidine affects pyroptosis by targeting GSDMD in myocardial ischemia/reperfusion injury - Xudong Chen; Shuang Lin; Shanshan Dai; Jibo Han; Peiren Shan; Weiqi Wang; Zhouqing Huang; Bozhi Ye; Weijian Huang (Inflammation Research, 2022)

N,P-codoped carbon quantum dots-decorated TiO2 nanowires as nanosized heterojunction photocatalyst with improved photocatalytic performance for methyl blue degradation - Liming Bai; Lumin Liu; Jinghui Pang; Zhao Chen; Minghui Wei; Yang Wu; Guohua Dong; Jianwei Zhang; Dan Shan; Baiqi Wang (Environmental Science and Pollution Research, 2022)

Effect of Copper Ion Sterilization on Bacterial Community in a Freshwater Recirculating Aquaculture System - Jianjun Shan; Xiaoqing Tian; Chongwu Guan; Chenglin Zhang; Yulei Zhang; Shi Chen (Current Microbiology, 2022)
The study aimed to evaluate the safety of copper ion sterilization based on copper ion residues in zebrafish ( Brachydanio rerio ), as well as bacterial community structure and diversity in recirculating aquaculture systems (RASs). The copper ion content was determined using national food safety standard GB 5009.13-2017. Bacterial community structures and alpha and beta diversity indexes were examined using the 16S rRNA gene sequences produced by Illumina HiSeq sequencing. The results revealed no significant copper ion enrichment in B. rerio when the copper ion concentration was 0.15 mg/L. The relative abundances of Erythrobacter , nitrite bacteria, and Flavanobacteria were clearly higher in the treatment group than in the control and differences in bacterial species richness and diversity were obvious. In addition, there was no sharp decrease in the microflora at the outflow of the copper ion generator. In conjunction with the changes in ammonia nitrogen, nitrate, and nitrite concentrations during the experiment, the results indicated that there were no significant effects on the purification efficacy of the biological filter, but the abundances of beneficial bacteria increased significantly. This is of great relevance in order to understand the response of bacterial communities affected by changing environmental conditions, such as copper ion sterilization.

Multiple Modulating Processes for Intensive Tropical Cyclone Activity Affecting Taiwan in September 2016 - Wei-Teh Li; Jau-Ming Chen; Ruo-Shan Tseng; Tzu-Ling Lai (Asia-Pacific Journal of Atmospheric Sciences, 2022)

Natural ingredient paeoniflorin could be a lead compound against white spot syndrome virus infection in Litopenaeus vannamei - Yang Hu; Lei Liu; Li‐peng Shan; Jiong Chen (Journal of Fish Diseases, 2022)
White spot syndrome virus (WSSV) is an important pathogen causing high mortality in the shrimp industry in aquaculture, yet there is no treatment available to date. In order to find a treatment against WSSV infection, this study examined the anti‐WSSV activity of eight natural compounds using shrimp larvae as a model. Among the eight compounds, paeoniflorin showed the most obvious anti‐WSSV effect, with a maximum protection efficiency of WSSV‐infected shrimp >60% at 100 μM. Furthermore, pretreatment and post‐treatment experiments revealed that paeoniflorin could prevent and treat WSSV infection in shrimp. The antiviral activity of paeoniflorin in aquaculture water decreased rapidly with time, and the results showed that the stable anti‐WSSV activity of paeoniflorin could only remain in water for 1 day. Thus, the dosing pattern of continuous medication changes was evaluated. Obviously, in the model of continuous change of paeoniflorin, WSSV copy numbers in the virus‐treated shrimp group still progressively increased, while the virus content in WSSV paeoniflorin ‐treated group continued to decrease. Interestingly, paeoniflorin inhibited horizontal transmission of WSSV to a certain extent. Notably, paeoniflorin significantly increased the expression of antimicrobial peptides of shrimp to resist WSSV. In conclusion, paeoniflorin has the potential to protect shrimp against WSSV.

Combined Use of eDNA Metabarcoding and Bottom Trawling for the Assessment of Fish Biodiversity in the Zhoushan Sea - Shan Zhou; Chenrong Fan; Haoming Xia; Jian Zhang; Wei Yang; Dengjie Ji; Lei Wang; Li Chen; Nannan Liu (Frontiers in Marine Science, 2022)
With the increase in fishing intensity and the intensification of marine pollution, the fishery resources in the Zhoushan Sea are seriously degraded, and the difficulty of censusing fish diversity hampers effective management in marine fishes. Environmental DNA metabarcoding and bottom trawl methods were used to determine the ability of the methods to distinguish fish assemblages in the Zhoushan Sea. The species composition and diversity of the Zhoushan Sea were assessed via high-throughput sequencing analysis of eDNA coupled with bottom trawl fishery survey data, after which the two methods were compared. eDNA screening identified 38.2% more fish species than bottom trawls. Combining these two methods, 33 orders, 65 families, and 130 species of fishes were identified. Perciformes and Clupeiformes, the most abundant orders in the catch, represented 31.5 and 10.0% of the total fish abundance, respectively. The results of ANOSIM and redundancy analyses indicated that the fish community structure varied significantly between summer and winter, however depth and temperature being the main environmental factors influencing fish distribution. The biodiversity index was higher in summer than in winter. Thus, our work provides more detailed seasonal data on biodiversity in the Zhoushan Sea, which is essential for the long-term management and conservation of coastal biodiversity. Compared with traditional survey methods, eDNA determination is highly sensitive, accurate, cost-efficient, and suitable for fish diversity studies in relevant sea areas. Although this approach cannot completely replace traditional methods, our findings demonstrate that it provides a reliable complementary method for assessing fish diversity in marine ecosystems.

Nfe2l2 Regulates Metabolic Rewiring and Epigenetic Reprogramming in Mediating Cancer Protective Effect by Fucoxanthin - Lujing Wang; Renyi Wu; Davit Sargsyan; Shan Su; Hsiao-Chen Kuo; Shanyi Li; Pochung Chou; Md Shahid Sarwar; Ameya Phadnis; Yujue Wang; Xiaoyang Su; Ah-Ng Kong (The AAPS Journal, 2022)

Distinct Recovery Process of Consciousness and Cognition After Anesthesia - Jiani Chen; Liang Shan; Ji Dai (Neuroscience Bulletin, 2022)

A community effort to assess and improve computerized interpretation of 12-lead resting electrocardiogram - Zijian Ding; Guijin Wang; Huazhong Yang; Ping Zhang; Dapeng Fu; Zhen Yang; Xinkang Wang; Xia Wang; Zhourui Xia; Chiming Zhang; Wenjie Cai; Binhang Yuan; et al. (Medical & Biological Engineering & Computing, 2022)
Computerized interpretation of electrocardiogram plays an important role in daily cardiovascular healthcare. However, inaccurate interpretations lead to misdiagnoses and delay proper treatments. In this work, we built a high-quality Chinese 12-lead resting electrocardiogram dataset with 15,357 records, and called for a community effort to improve the performances of CIE through the China ECG AI Contest 2019. This dataset covers most types of ECG interpretations, including the normal type, 8 common abnormal types, and the other type which includes both uncommon abnormal and noise signals. Based on the Contest, we systematically assessed and analyzed a set of top-performing methods, most of which are deep neural networks, with both their commonalities and characteristics. This study establishes the benchmarks for computerized interpretation of 12-lead resting electrocardiogram and provides insights for the development of new methods.

Antiviral activity of esculin against white spot syndrome virus: A new starting point for prevention and control of white spot disease outbreaks in shrimp seedling culture - Li‐Peng Shan; Xu Zhang; Yang Hu; Lei Liu; Jiong Chen (Journal of Fish Diseases, 2022)
White spot syndrome virus (WSSV) is a pathogenic and threatening virus in shrimp culture for which there is no effective control strategy. Finding antiviral lead compounds for the development of anti‐WSSV drugs is urgent and necessary; in this study, esculin from 12 monomeric compounds exhibited an excellent anti‐WSSV activity. The results showed that esculin increased the survival rate of WSSV‐infected shrimps by 59% and reduced the virus copy number in vivo over 90% at 100 μM. In the pre‐treatment and post‐treatment experiments, esculin could prevent and treat WSSV infection. Compared with the control group, the virus copy number decreased by 30% after 6 h of esculin pre‐incubation with WSSV particles and inhibited horizontal transmission of WSSV to a certain extent. Considering that the antiviral activity of esculin was stable in the aquacultural water for 2 days, we evaluated the dosing pattern of continuous medication changes. Obviously, the survival rate of WSSV‐infected shrimps was 0% at 108 h when no esculin exchange was made, while at 120 h the survival rate was over 40% at continuous medicine changes. In addition, esculin significantly increased the expression of antimicrobial peptides and thus improved the ability of shrimp to resist WSSV. Overall, our findings suggest that esculin has the potential to be developed into an anti‐WSSV medicine.

Efficient induction of neural progenitor cells from human ESC/iPSCs on Type I Collagen - Pengfei Liu; Shubin Chen; Yaofeng Wang; Xiaoming Chen; Yiping Guo; Chunhua Liu; Haitao Wang; Yifan Zhao; Di Wu; Yongli Shan; Jian Zhang; Chuman Wu; et al. (Science China Life Sciences, 2021)

Anti-Adhesion Effects of Lactobacillus Strains on Caco-2 Cells Against Escherichia Coli and Their Application in Ameliorating the Symptoms of Dextran Sulfate Sodium-Induced Colitis in Mice - Tao Wang; Huimin Sun; Jiaxin Chen; Lingli Luo; Yaxin Gu; Xin Wang; Yuanyuan Shan; Yanglei Yi; Bianfang Liu; Yuan Zhou; Xin Lü (Probiotics and Antimicrobial Proteins, 2021)

Hotter and drier climate made the Mediterranean Europe and Northern Africa region a shrubbier landscape - Wei Fang; Chuixiang Yi; Deliang Chen; Peipei Xu; George Hendrey; Nir Krakauer; Katherine Jensen; Shan Gao; Zihan Lin; Gabriella Lam; Qin Zhang; Tao Zhou (Oecologia, 2021)

Synthesis and evaluation of mycophenolic acid derivatives as potential anti-Toxoplasma gondii agents - Fan-Fan Shang; Mei-Yuan Wang; Jiang-Ping Ai; Qing-Kun Shen; Hong-Yan Guo; Chun-Mei Jin; Fen-Er Chen; Zhe-Shan Quan; Lili Jin; Changhao Zhang (Medicinal Chemistry Research, 2021)

A comparison of atmospheric geochemistry through lichens from volcanic and non-volcanic areas, north Taiwan - Le-Qi Lin; Hsueh-Yu Lu; Ju-Lien Pi; Tai-Sheng Liou; Wen-Fu Chen; Pei-Shan Hsieh (Journal of Earth System Science, 2021)

Catalytic ozone oxidation toluene over supported manganese cobalt composite: influence of catalyst support - Jingxiu Shen; Ning Gao; Yao Shan; Mingqing Liu; Jining Liu; Yuan Xu; Shubao Shen; Yingwen Chen (Environmental Science and Pollution Research, 2021)

Dielectric constants of organic pollutants determine their strength for enhancing microbial iron reduction - Shan Liu; Hui Liu; Yao Huang; Jie Ma; Zhu Wang; Rong Chen (Environmental Science and Pollution Research, 2021)

Antibiotic accumulation, growth performance, intestinal diversification, and function of Nile tilapia (Oreochromis niloticus) feed by diets supplemented with different doses of sulfamethoxazole - Longxiang Fang; Xi Chen; Xiangbao Shan; Liping Qiu; Limin Fan; Shunlong Meng; Chao Song (Environmental Science and Pollution Research, 2021)

Study on Tailings Covering System Constructed by Geological Polymerization of Mine Waste, Part 1: Material Characterization and Cover Construction - Yunjian Chen; Senlin Tian; Jiangli Fu; Yichao Lin; Jianhong Huang; Shan Chen; Xuewei Hu (Bulletin of Environmental Contamination and Toxicology, 2021)

Plant Species Diversity of Plant Communities and Heavy Metal Accumulation in Buffer Zone of Momianhe Stream Along a Long-Term Mine Wastes Area, China - Jiangdi Deng; Bo Li; Shan Zhang; Zuran Li; Yanqun Zu; Yongmei He; Jianjun Chen; Tianguo Li (Bulletin of Environmental Contamination and Toxicology, 2021)

Generation and characterization of a Myh6-driven Cre knockin mouse line - Xinyan Huang; Lei Yan; Shan Kou; Jufeng Meng; Zhengkai Lu; Chao-Po Lin; Chen Liu; Hui Zhang (Transgenic Research, 2021)
Gene deletion by the Cre-Loxp system has facilitated functional studies of many critical genes in mice, offering important insights and allowing deeper understanding on the mechanisms underlying organ development and diseases, such as heart development and diseases. In this study, we generated a Myh6-Cre knockin mouse model by inserting the IRES-Cre-wpre-polyA cassette between the translational stop codon and the 3′ untranslated region of the endogenous Myh6 gene. By crossing knockin mice with the Rosa26 reporter lines, we found that Myh6-Cre targeted cardiomyocytes at the embryonic and postnatal stages. In addition, we were able to inactivate the desmosome gene Desmoplakin (Dsp) by breeding Myh6-Cre mice with a conditional Dsp flox knockout mouse line, which resulted in embryonic lethality during the mid-term pregnancy. These results suggest that the new Myh6-Cre mouse line can serve as a robust tool to dissect the distinct roles of genes involved in heart development and function.

Development and characterization of 33 SNP markers in a critically endangered Hynobius amjiensis using ddRAD sequencing - Xia Kan; Guoliang Wang; Lili Zhang; Xin Zhao; Shuangshuang Shan; Guiming Liu; Chen Shao; Yu Wang (Conservation Genetics Resources, 2021)

Experimental Research on Cavitation Evolution and Movement Characteristics of the Projectile during Vertical Launching - Siru Chen; Yao Shi; Guang Pan; Shan Gao (Journal of Marine Science and Engineering, 2021)
Aiming at the problem of unsteady cavitation during a projectile’s vertical water-exit process, scaled model experiments were carried out based on the self-designed underwater launch platform and high-speed cameras, which focus on changes in cavitation shape and projectile posture. In this paper, the general process of the cavitation evolution and projectile’s movement is described; the relationship between the re-entry jet, local cavitation number and cavitation stability is discussed. Meanwhile, the effect of head forms and launch speeds on the cavitation evolution and movement characteristics is analyzed, including 60° cone, 90° cone and hemispherical head with velocity of 16.8 m/s, 18.5 m/s and 20.0 m/s, whose launch cavitation number is 0.714, 0.589 and 0.504. The results show that the attached cavities fall off from the bottom up under the influence of the end-re-entry jet and the shedding frequency declines when the launch cavitation number decreases. The cavitation growth of 60° cone is easily disturbed by the air mass near the launcher, the cavitation development of 90° cone is characterized by small-scale and high-frequency growth and shedding, while the hemispherical head is not prone to cavitation. Moreover, increasing the speed can improve the stability of cavitation development and the projectile’s movement.

Evaluation of long-term performance of plant microbial fuel cells using agricultural plants under the controlled environment - Natagarn Tongphanpharn; Chung-Yu Guan; Wei-Shan Chen; Chao-Chin Chang; Chang-Ping Yu (Clean Technologies and Environmental Policy, 2021)

Evidence for the role of KIF17 in fish spermatid reshaping: expression pattern of KIF17 in Larimichthys polyactis spermiogenesis - Jingqian Wang; Xinming Gao; Xuebin Zheng; Chen Du; Congcong Hou; Qingping Xie; Bao Lou; Feng Liu; Shan Jin; Junquan Zhu (Journal of Oceanology and Limnology, 2021)

Influence of water and salt on suction characteristics of unsaturated clay: variation, mechanism, and fitting - Huie Chen; Jinfeng Li; Xiaoqing Yuan; Bin Shi; WenChong Shan (Bulletin of Engineering Geology and the Environment, 2021)

Fe induces a dynamic and biased allocation of material flux within terpenoid metabolism controlled by CbNudix in Conyza blinii - Tianrun Zheng; Junyi Zhan; Maojia Wang; Wenjun Sun; Jun Yan; Zhi Shan; Hui Chen (Plant and Soil, 2021)

A review of the botany, traditional uses, phytochemistry and pharmacology of Nepeta tenuifolia Briq. - Mingqiu Shan; Yulan Jiang; Yuanyuan Fu; Yongyi Zhou; Zhihui Lu; Sheng Yu; Hui Yan; Chanchan Liu; Peidong Chen; Beihua Bao; Li Zhang; Qinan Wu (Phytochemistry Reviews, 2021)

Metabolic responses of Chinese perch (Siniperca chuatsi) to different levels of dietary carbohydrate - Yanpeng Zhang; Xu-fang Liang; Shan He; Jie Wang; Ling Li; Zhen Zhang; Jiao Li; Xu Chen; Lu Li; Muhammad Shoaib Alam (Fish Physiology and Biochemistry, 2021)

Pollution Characteristics of Microplastics in Mollusks from the Coastal Area of Yantai, China - Jiajia Liu; Xiaopeng Zhu; Jia Teng; Jianmin Zhao; Chenghua Li; Encui Shan; Chen Zhang; Qing Wang (Bulletin of Environmental Contamination and Toxicology, 2021)

Dynamic characteristics of Xianyang loess based on microscopic analysis: a quantitative evaluation - Huie Chen; Wenchong Shan; Yaling Jiang (Bulletin of Engineering Geology and the Environment, 2021)

Impact of diagenesis on the sandstone reservoir quality: a case study from the Lower Jurassic Sangonghe Formation, Junggar Basin, China - Xiang Shan; Huajun Guo; Wenjun He; Xiguang Chen; Xueqiang Si; Yang Xu (Arabian Journal of Geosciences, 2021)

Preparation, Characterization, and In Vitro/In Vivo Evaluation of 3-O-β-D-Galactosylated Resveratrol-Loaded Polydopamine Nanoparticles - Beilei Wang; Xiaoxiao Shan; Shujie Lv; Liqiong Zha; Caiyun Zhang; Qiannian Dong; Weidong Chen (AAPS PharmSciTech, 2021)

Large-scale integration of meta-QTL and genome-wide association study discovers the genomic regions and candidate genes for yield and yield-related traits in bread wheat - Yang Yang; Aduragbemi Amo; Di Wei; Yongmao Chai; Jie Zheng; Pengfang Qiao; Chunge Cui; Shan Lu; Liang Chen; Yin-Gang Hu (Theoretical and Applied Genetics, 2021)

Research on numerical simulation of typhoon waves with different return periods in nearshore areas: case study of Guishan island Waters in Guangdong province, China - Shi Xianwu; Zheng Shuxian; Liu Qiang; Fang Jian; Chen Qiang; Jia Ning; Liu Shan; Zhou Shuihua (Stochastic Environmental Research and Risk Assessment, 2021)

Lipidomic analyses reveal enhanced lipolysis in planthoppers feeding on resistant host plants - Xiaohong Zheng; Yeyun Xin; Yaxin Peng; Junhan Shan; Ning Zhang; Di Wu; Jianping Guo; Jin Huang; Wei Guan; Shaojie Shi; Cong Zhou; Rongzhi Chen; et al. (Science China Life Sciences, 2021)

Maternal Subclinical Hypothyroidism in Rats Impairs Spatial Learning and Memory in Offspring by Disrupting Balance of the TrkA/p75NTR Signal Pathway - Fan Zhang; Xinyue Lin; Aihua Liu; Jian Chen; Zhongyan Shan; Weiping Teng; Xiaohui Yu (Molecular Neurobiology, 2021)
Maternal subclinical hypothyroidism (SCH) during pregnancy can adversely affect the neurodevelopment of the offspring. The balance of nerve growth factor (NGF)-related tropomyosin receptor kinase A/p75 neurotrophin receptor (TrkA/p75 NTR ) signaling in the hippocampus is important in brain development, and whether it affects cognitive function in maternal SCH’s offspring is not clear. In this study, we found that compared with the control (CON) group, expression of proliferation-related proteins [NGF, p-TrkA, phospho-extracellular signal-regulated kinase 1/2 (p-ERK1/2) and phospho-cAMP response element-binding protein (p-CREB)] decreased in the hippocampus of the offspring in the SCH group, overt hypothyroidism (OHT) group, and the group with levothyroxine (L-T 4 ) treatment for SCH from gestational day 17 (E17). In contrast, expression of apoptosis-related proteins [pro-NGF, p75 NTR , phospho-C-Jun N-terminal kinase (p-JNK), p53, Bax and cleaved caspase-3] was increased. The two groups with treatment with L-T 4 for SCH from E10 and E13, respectively, showed no significant difference compared with the CON group. L-T 4 treatment enhanced relative expression of NGF by increasing NGF/proNGF ratio in offspring from maternal SCH rats. In conclusion, L-T 4 treatment for SCH from early pregnancy dramatically ameliorated cognitive impairment via TrkA/p75 NTR signaling, which involved activation of the neuronal proliferation and inhibition of neuronal apoptosis in SCH rats’ offspring.

Octamer transcription factor-1 induces the Warburg effect via up-regulation of hexokinase 2 in non-small cell lung cancer - Zhen Li; Jin Su; Mingming Sun; Jiaqi Song; Huanran Sun; Jun Fan; Guo Chen; Changliang Shan; Qi Qi; Shuai Zhang (Molecular and Cellular Biochemistry, 2021)

The advances of topology optimization techniques in orthopedic implants: A review - Naichao Wu; Shan Li; Boyan Zhang; Chenyu Wang; Bingpeng Chen; Qing Han; Jincheng Wang (Medical & Biological Engineering & Computing, 2021)

Taurine Reduces Liver Damage in Non-Alcoholic Fatty Liver Disease Model in Rats by Down-Regulating IL-9 and Tumor Growth Factor TGF-β - Z. Yao; G. Liang; Z. L. Lv; L. C. Lan; F. L. Zhu; Q. Tang; L. Huang; X. Q. Chen; M. X. Yang; Q. W. Shan (Bulletin of Experimental Biology and Medicine, 2021)

Efficient and high-fidelity base editor with expanded PAM compatibility for cytidine dinucleotide - Zhiquan Liu; Siyu Chen; Yingqi Jia; Huanhuan Shan; Mao Chen; Yuning Song; Liangxue Lai; Zhanjun Li (Science China Life Sciences, 2021)

Atg7 Knockout Alleviated the Axonal Injury of Neuro-2a Cells Induced by Tri-Ortho-Cresyl Phosphate - Cuiqin Zhang; Kang Kang; Yisi Chen; Shulin Shan; Keqin Xie; Fuyong Song (Neurotoxicity Research, 2021)

Patient Confidential Information Transmission Using the Integration of PSO-Based Biomedical Signal Steganography and Threshold-Based Compression - Shih-Ying Chen; Shan-Ju Lin; Ming-Cheng Tsai; Ming-Dar Tsai; Yih-Jing Tang; Shuo-Tsung Chen; Li-Hsiang Wang (Journal of Medical and Biological Engineering, 2021)

Porcine circovirus type 2 (PCV2) infection in Hebei Province from 2016 to 2019: a retrospective study - Lei Han; Guang-fu Yuan; Shao-jie Chen; Fei Dai; Lin-shan Hou; Jing-hui Fan; Yu-zhu Zuo (Archives of Virology, 2021)

Geographic and subsequent biotic isolations led to a diversity anomaly of section Heterotropa (genus Asarum : Aristolochiaceae) in insular versus continental regions of the Sino‐Japanese Floristic Region - Daiki Takahashi; Shota Sakaguchi; Yu Feng; Yuji Isagi; Ying‐Xiong Qiu; Pan Li; Rui‐Sen Lu; Chang‐Tse Lu; Shih‐Wen Chung; Yang‐Shan Lin; Yun‐Chao Chen; Atsushi J. Nagano; et al. (Journal of Biogeography, 2021)
Aim The Sino‐Japanese Floristic Region has extremely high species diversity with respect to temperate plants; however, the reasons for this diversity are poorly understood because most studies have only considered geographic isolation caused by climatic oscillations. In some plant groups, high floral trait diversity and uneven species diversity between insular systems and the continental area suggest other factors may have important roles too. The primary purpose of this study is to reveal how abiotic and biotic factors have shaped the species diversity anomaly of Heterotropa between the insular systems and the continental area. Location The Sino‐Japanese Floristic Region. Taxon Section Heterotropa (genus Asarum ; Aristolochiaceae). Methods Using ddRAD‐seq and chloroplast genome data, we built a time‐calibrated phylogenetic tree including 79 species. We estimated the patterns of floral traits (flowering time and floral size) evolution using macroevolutionary modelling, and tested the correlation of speciation rate with the trait evolution rates. Finally, we estimated the isolation factors of all taxa pairs and sister‐taxa pairs based on distribution range and floral traits. Results Phylogenetic analysis indicated that Heterotropa was diverged into two clades (continental clade and insular clade) in the Miocene, and the major subclades corresponded to geographic entities. Most rate shifts accelerating floral trait's evolution occurred during the Pleistocene period. Evolution rate of floral traits showed positive correlation with the speciation rate. Large proportion of taxa in the insular clade are distributed allopatrically. Several sister pairs showed floral trait divergence with geographic overlap. Main Conclusions The diversification of Heterotropa appears to have been triggered by geographic and climatic events, and subsequent repeated floral trait evolution with and without geographic isolation. Furthermore, the high species diversity in the insular systems would have been formed by the repeated range fragmentations and contractions. Our study demonstrates the importance of multidimensional studies to understand the diversification process of temperate plants in the Sino‐Japanese Floristic Region.

Two new pregnane steroidal glycosides from Cynanchum taihangense - Yu-Bo Wang; Shan-Shan Su; Ming-Xu Tang; Dan Zhao; Gang Chen; Shao-Fei Chen; Hai-Feng Wang; Yue-Hu Pei (Natural Product Research, 2021)

Variation in Micro-Pores during Dynamic Consolidation and Compression of Soft Marine Soil - Chen-Xiang Dai; Qiong-Fang Zhang; Shao-Heng He; An Zhang; Hua-Feng Shan; Tang-Dai Xia (Journal of Marine Science and Engineering, 2021)
In this study, to explore the microstructure deformation mechanism of marine soft marine soil under cyclic loading, we analyzed the dynamic properties of soft marine soil under cyclic loading via dynamic consolidation compression testing. Then, using Image-Pro Plus (IPP) 6.0 image analysis software, and according to the dynamic consolidation compression test results and the images from a scanning electron microscope (SEM), we determined the weakening effect of soft soils under different consolidation confining pressures, different cyclic stress ratios, and different over-consolidation ratios. After dynamic consolidation and compression, the pore structure of undisturbed soft marine soil tends to compact, the degree of soil particle fragmentation intensifies, small pores increase, large pores decrease, the pores become more regular, and the distribution of pores is directional. Subsequently, for undisturbed soft marine soil, the higher the consolidated confining pressure, cyclic dynamic stress ratio, and over-consolidation ratio, the greater the damage to the pore structure, and the more obvious the structural weakening effect exhibited under cyclic loading.

Hemin-induced increase in saponin content contributes to the alleviation of osmotic and cold stress damage to Conyza blinii in a heme oxygenase 1-dependent manner - Tianrun Zheng; Junyi Zhan; Ming Yang; Maojia Wang; Wenjun Sun; Zhi Shan; Hui Chen (Journal of Zhejiang University-SCIENCE B, 2021)

TRIM21 inhibits porcine epidemic diarrhea virus proliferation by proteasomal degradation of the nucleocapsid protein - Hua Wang; Xiaoyong Chen; Ning Kong; Yajuan Jiao; Dage Sun; Sujie Dong; Wenzhen Qin; Huanjie Zhai; Lingxue Yu; Hao Zheng; Wu Tong; Hai Yu; et al. (Archives of Virology, 2021)

Detection of Vestibular Schwannoma on Triple-parametric Magnetic Resonance Images Using Convolutional Neural Networks - Tzu-Hsuan Huang; Wei-Kai Lee; Chih-Chun Wu; Cheng-Chia Lee; Chia-Feng Lu; Huai-Che Yang; Chun-Yi Lin; Wen-Yuh Chung; Po-Shan Wang; Yen-Ling Chen; Hsiu-Mei Wu; Wan-You Guo; et al. (Journal of Medical and Biological Engineering, 2021)
Purpose The first step in typical treatment of vestibular schwannoma (VS) is to localize the tumor region, which is time-consuming and subjective because it relies on repeatedly reviewing different parametric magnetic resonance (MR) images. A reliable, automatic VS detection method can streamline the process. Methods A convolutional neural network architecture, namely YOLO-v2 with a residual network as a backbone, was used to detect VS tumors from MR images. To heighten performance, T1-weighted–contrast-enhanced, T2-weighted, and T1-weighted images were combined into triple-channel images for feature learning. The triple-channel images were cropped into three sizes to serve as input images of YOLO-v2. The VS detection effectiveness levels were evaluated for two backbone residual networks that downsampled the inputs by 16 and 32. Results The results demonstrated the VS detection capability of YOLO-v2 with a residual network as a backbone model. The average precision was 0.7953 for a model with 416 × 416-pixel input images and 16 instances of downsampling, when both the thresholds of confidence score and intersection-over-union were set to 0.5. In addition, under an appropriate threshold of confidence score, a high average precision, namely 0.8171, was attained by using a model with 448 × 448-pixel input images and 16 instances of downsampling. Conclusion We demonstrated successful VS tumor detection by using a YOLO-v2 with a residual network as a backbone model on resized triple-parametric MR images. The results indicated the influence of image size, downsampling strategy, and confidence score threshold on VS tumor detection.

Genetic Architecture of Childhood Kidney and Urological Diseases in China - Ye Fang; Hua Shi; Tianchao Xiang; Jiaojiao Liu; Jialu Liu; Xiaoshan Tang; Xiaoyan Fang; Jing Chen; Yihui Zhai; Qian Shen; Guomin Li; Li Sun; et al. (Phenomics, 2021)
Kidney disease is manifested in a wide variety of phenotypes, many of which have an important hereditary component. To delineate the genotypic and phenotypic spectrum of pediatric nephropathy, a multicenter registration system is being implemented based on the Chinese Children Genetic Kidney Disease Database (CCGKDD). In this study, all the patients with kidney and urological diseases were recruited from 2014 to 2020. Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features. The genetic diagnosis was confirmed in 883 of 2256 (39.1%) patients from 23 provinces in China. Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome (SRNS, 23.5%), glomerulonephritis (GN, 32.2%), congenital anomalies of the kidney and urinary tract (CAKUT, 21.2%), cystic renal disease (3.9%), renal calcinosis/stone (3.6%), tubulopathy (9.7%), and chronic kidney disease of unknown etiology (CKDu, 5.8%). The pathogenic variants of 105 monogenetic disorders were identified. Ten distinct genomic disorders were identified as pathogenic copy number variants (CNVs) in 11 patients. The diagnostic yield differed by subgroups, and was highest in those with cystic renal disease (66.3%), followed by tubulopathy (58.4%), GN (57.7%), CKDu (43.5%), SRNS (29.2%), renal calcinosis /stone (29.3%) and CAKUT (8.6%). Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions. We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed. Our data demonstrate the utility of family-based exome sequencing, and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease.

Recreational Nitrous Oxide Abuse: Prevalence, Neurotoxicity, and Treatment - Yuanyuan Xiang; Lei Li; Xiaotong Ma; Shan Li; Yuan Xue; Peng Yan; Meijie Chen; Junwei Wu (Neurotoxicity Research, 2021)

The Antibacterial Properties of 4, 8, 4′, 8′-Tetramethoxy (1,1′-biphenanthrene) -2,7,2′,7′-Tetrol from Fibrous Roots of Bletilla striata - Xue-Jiao Huang; Nan Xiong; Bo-Chen Chen; Fan Luo; Min Huang; Zhi-Shan Ding; Chao-Dong Qian (Indian Journal of Microbiology, 2021)

The effects of autophagy in rat tracheal epithelial cells induced by silver nanoparticles - Hangjun Zhang; Feifei Chen; Yan Li; Xiaodong Shan; Lu Yin; Xiaojing Hao; Yuchi Zhong (Environmental Science and Pollution Research, 2021)

Pore and compression characteristics of clay solidified by ionic soil stabilizer - Xue-Ting Wu; Jin-Shan Sun; Yi Qi; Bin Chen (Bulletin of Engineering Geology and the Environment, 2021)

Tritonibacter aquimaris sp. nov. and Tritonibacter litoralis sp. nov., two novel members of the Roseobacter group isolated from coastal seawater - Na Li; Xiao-yan He; Ning-hua Liu; Tie-ji Gu; Jian Li; Yu-hui Geng; Shan Zhang; Peng Wang; Hui-hui Fu; Mei Shi; Xiu-lan Chen; Yu-zhong Zhang; et al. (Antonie van Leeuwenhoek, 2021)

Marinobacter orientalis sp. nov., a thiosulfate-oxidizing bacterium isolated from a marine solar saltern - Feng-Bai Lian; Xu-Yang Chen; Shan Jiang; Guang-Yu Li; Zong-Jun Du (Antonie van Leeuwenhoek, 2021)

Microbial community structure in PM2.5 affected by burning fireworks during the 2019 Spring Festival in Guilin, a touristic city in South China - Tengfa Long; Bin Peng; Zhihui Yang; Ziwei Ye; Chunqiang Chen; Qiang Huo; Shan Zhong (Aerobiologia, 2021)

Formyl tetrahydrofolate deformylase affects hydrogen peroxide accumulation and leaf senescence by regulating the folate status and redox homeostasis in rice - Erhui Xiong; Guojun Dong; Fei Chen; Chen Zhang; Shan Li; Yanli Zhang; Jahidul Islam Shohag; Xiaoe Yang; Yihua Zhou; Qian Qian; Limin Wu; Yanchun Yu (Science China Life Sciences, 2021)

Spatial prediction of soil calcium carbonate content based on Bayesian maximum entropy using environmental variables - Mei Shan; Shuang Liang; Hongchen Fu; Xiaoli Li; Yu Teng; Jingwen Zhao; Yaxin Liu; Chen Cui; Li Chen; Hai Yu; Shunbang Yu; Yanling Sun; et al. (Nutrient Cycling in Agroecosystems, 2021)

The hand-arm vibration syndrome associated with the grinding of handheld workpieces in a subtropical environment - Nuoyan Wei; Hansheng Lin; Ting Chen; Bin Xiao; Maosheng Yan; Li Lang; Hongyu Yang; Shan Wu; Paul-Émile Boileau; Qingsong Chen (International Archives of Occupational and Environmental Health, 2021)

Building change detection in very high-resolution remote sensing image based on pseudo-orthorectification - Hui Chen; Ka Zhang; Wen Xiao; Yehua Sheng; Liang Cheng; Wei Zhou; Pengbo Wang; Dong Su; Longjie Ye; Shan Zhang (International Journal of Remote Sensing, 2021)

An Effective Method for Wetland Park Health Assessment: a Case Study of the Guangdong Xinhui National Wetland Park in the Pearl River Delta, China - Xiao-Shan Fang; Shuang Liu; Wei-Zhi Chen; Ren-Zhi Wu (Wetlands, 2021)
The Guangdong Xinhui National Wetland Park (GXNWP) in the Pearl River Delta is an important stopover for migratory birds in China and East Asia. Due to high levels of interference, high sensitivity and fragile environmental constraints, an efficient method to assess the health status of wetland parks such as the GXNWP is urgently needed for sustainable development. In this study, we proposed a habitat-landscape-service (HLS) conceptual model that can be used at the site scale to evaluate health status in terms of habitats, landscapes and services by considering the complex ecosystem of wetland parks. This HLS model included 28 evaluation indicators, and the indicator weights and health-grade divisions were based on expert scores using both the analytic hierarchy process (AHP) and fuzzy comprehension evaluation (FCE) methods. The results showed that the health status of the GXNWP was at the “subhealthy” level, with a membership function of 0.4643. This study found that habitat indicators (0.5715) were the key factors affecting the GXNWP health status, followed by service indicators (0.2856) and landscape indicators (0.1429). The HLS-AHP-FCE method provides a holistic health evaluation indicator system and diagnostic approach for rapidly developing wetland parks in the Pearl River Delta, China.

Exogenous ABA and its inhibitor regulate flower bud induction of apple cv. ‘Nagafu No. 2′ grafted on different rootstocks - Wen-Fang Li; Juan Mao; Jing Su; Xin-Wen Li; Mohammed Mujitaba Dawuda; Zong-Huan Ma; Cun-Wu Zuo; Ze-Shan An; Bai-Hong Chen (Trees, 2021)

Treatment of Aggressive T Cell Lymphoblastic Lymphoma/leukemia Using Anti-CD5 CAR T Cells - Jia Feng; Haichan Xu; Andrew Cinquina; Zehua Wu; Qi Chen; Ping Zhang; Xingen Wang; Huiming Shan; Lei Xu; Qian Zhang; Lihua Sun; Wenli Zhang; et al. (Stem Cell Reviews and Reports, 2021)
While treatment for B-cell malignancies has been revolutionized through the advent of CAR immunotherapy, similar strategies for T-cell malignancies have been limited. Additionally, T-cell leukemias and lymphomas can commonly metastasize to the CNS, where outcomes are poor and treatment options are associated with severe side effects. Consequently, the development of safer and more effective alternatives for targeting malignant T cells that have invaded the CNS remains clinically important. CD5 CAR has previously been shown to effectively target various T-cell cancers in preclinical studies. As IL-15 strengthens the anti-tumor response, we have modified CD5 CAR to secrete an IL-15/IL-15sushi complex. In a Phase I clinical trial, these CD5-IL15/IL15sushi CAR T cells were tested for safety and efficacy in a patient with refractory T-LBL with CNS infiltration. CD5-IL15/IL15sushi CAR T cells were able to rapidly ablate the CNS lymphoblasts within a few weeks, resulting in the remission of the patient’s lymphoma. Despite the presence of CD5 on normal T cells, the patient only experienced a brief, transient T-cell aplasia. These results suggest that CD5-IL15/IL15sushi CAR T cells may be a safe and useful treatment of T-cell malignancies and may be particularly beneficial for patients with CNS involvement. Graphical Abstract

Comparison of myocardial ischemic/hypoxic staining techniques for evaluating the alleviation of exhaustive exercise-induced myocardial injury by exercise preconditioning - Yue Huang; Shan- Shan Pan; Yuan-Pan Guo; Jia-Yin Wang; Dong-Feng Wan; Tian-Ran Chen; Jian-Qi Yuan (Journal of Molecular Histology, 2021)

Microbiological profiles and antimicrobial resistance patterns of pediatric bloodstream pathogens in China, 2016–2018 - Yue Qiu; Junwen Yang; Yiping Chen; Jinhong Yang; Qingxiong Zhu; Chunhui Zhu; Shuangjie Li; Jing Liu; Chaomin Wan; Yu Zhu; Minxia Chen; Yi Xu; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Characteristics of Atmospheric Rivers over the East Asia in Middle Summers from 2001 to 2016 - Gang Fu; Shan Liu; Xiaodong Li; Pengyuan Li; Lijia Chen (Journal of Ocean University of China, 2021)

Numerical simulation of roof movement and fill strength of coal deep mining - Tao Li; Baogui Yang; Zheng Qi; Chengjin Gu; Qiyuan Shan; Weixin Chen (Arabian Journal of Geosciences, 2021)

Effects of habitat fragmentation on the demography of the critically endangered tree Pterospermum kingtungense (Sterculiaceae) in Yunnan, China - Chun-Ming Yuan; Shan-Shan Zhang; Guo-Ping Yang; Jian Chen; Yun-Fen Geng; Xiao-Shuang Li; Wen-Zhong Yang (Tropical Ecology, 2021)

Elevated L-lactate Promotes Major Cellular Pathologies Associated with Neurodegenerative Diseases - Andrew D. Chapp; Jessica E. Behnke; Kyle M. Driscoll; Taija Hahka; Zoe LaLonde; Zhiying Shan; Qing-Hui Chen (Neuroscience Bulletin, 2021)

Enhanced antioxidant capacity and upregulated transporter genes contribute to the UV-B-induced increase in blinin in Conyza blinii - Junyi Zhan; Qin Yang; Zhiyi Lin; Tianrun Zheng; Maojia Wang; Wenjun Sun; Tongliang Bu; Zizhong Tang; Chenglei Li; Xueyi Han; Haixia Zhao; Qi Wu; et al. (Environmental Science and Pollution Research, 2021)

Mechanism of pore water seepage in soil reinforced by step vacuum preloading - Wenchong Shan; Hui-e Chen; Xiaoqing Yuan; Wenliang Ma; Hui Li (Bulletin of Engineering Geology and the Environment, 2021)

Continental shelf morphology controlled by bottom currents, mud diapirism, and submarine slumping to the east of the Gaoping Canyon, off SW Taiwan - Yi-Ching Yeh; Chung-Lin Tsai; Shu-Kun Hsu; Hsiao-Shan Lin; Kuan-Ting Chen; Yen-Yu Cho; Chin-Wei Liang (Geo-Marine Letters, 2021)

Molecular characterization of structural protein genes of dengue virus serotype 1 epidemic in Yunnan, Southwest China, in 2018 - Qingping Lan; Yun Shu; Linhao Li; Xiyun Shan; Dehong Ma; Tingting Li; Xiaodan Wang; Yue Pan; Junying Chen; Juan Zhang; Pinghua Liu; Qiangming Sun (Archives of Virology, 2021)

Disinfection efficiency of hospital infectious disease wards with chlorine dioxide and hypochlorous acid - Ming-Chun Lu; Po-Lin Chen; Da-Ji Huang; Chih-Kuo Liang; Ching-Shan Hsu; Wei-Ting Liu (Aerobiologia, 2021)

Sea surface temperature retrieval based on simulated microwave polarimetric measurements of a one-dimensional synthetic aperture microwave radiometer - Mengyan Feng; Weihua Ai; Wen Lu; Chengju Shan; Shuo Ma; Guanyu Chen (Acta Oceanologica Sinica, 2021)

A burned area mapping method for the FY-3D MERSI based on the single-temporal L1 data and multi-temporal daily active fire products - Tianchan Shan; Wei Zheng; Jie Chen; Shihao Tang (International Journal of Remote Sensing, 2021)

Coupling Singular Spectrum Analysis with Least Square Support Vector Machine to Improve Accuracy of SPI Drought Forecasting - Quoc Bao Pham; Tao-Chang Yang; Chen-Min Kuo; Hung-Wei Tseng; Pao-Shan Yu (Water Resources Management, 2021)

iTRAQ-based proteomic analysis reveals positive impacts of arbuscular mycorrhizal fungi inoculation on photosynthesis and drought tolerance in blueberry - Liang-Xian Gui; Shan-Shan Lu; Qiang Chen; Lu Yang; Jia-Xin Xiao (Trees, 2021)

Regulation of Cued Fear Expression via Corticotropin-Releasing-Factor Neurons in the Ventral Anteromedial Thalamic Nucleus - Yin Lv; Peng Chen; Qing-Hong Shan; Xin-Ya Qin; Xiu-Hong Qi; Jiang-Ning Zhou (Neuroscience Bulletin, 2021)

Morphological, cytological, and pigment analysis of leaf color variants regenerated from long-term subcultured caladium callus - Jin-Jin Chen; Yuan-Shan Zhang; Jia-Xin Duan; Yun-Mei Cao; Xiao-Dong Cai (In Vitro Cellular & Developmental Biology - Plant, 2021)

Genome-Wide Investigation and Expression Profiling Under Abiotic Stresses of a Soybean Unknown Function (DUF21) and Cystathionine-β-Synthase (CBS) Domain-Containing Protein Family - Qingnan Hao; Yanyan Yang; Zhihui Shan; Haifeng Chen; Chanjuan Zhang; Limiao Chen; Songli Yuan; Xiaojuan Zhang; Shuilian Chen; Zhonglu Yang; Dezhen Qiu; Xinan Zhou (Biochemical Genetics, 2021)
Cystathionine-β-synthase (CBS) domain-containing proteins (CDCPs) constitute a large family in plants, and members of this family have been implicated in a variety of biological processes. However, the precise functions and the underlying mechanisms of most members of this family in plants remain to be elucidated. CBSDUF proteins belong to the CDCP superfamily, which contains one domain of unknown function (DUF21) and an N terminus that is adjacent to two intracellular CBS domains. In this study, a comprehensive genome database analysis of soybean was performed to investigate the role(s) of these CBSDUFs and to explore their nomenclature, classification, chromosomal distribution, exon–intron organization, protein structure, and phylogenetic relationships; the analysis identified a total of 18 putative CBSDUF genes. Using specific protein domains and phylogenetic analysis, the CBSDUF gene family was subdivided into eight groups. The soybean CBSDUF genes showed an uneven distribution on 12 chromosomes of Glycine max . RNA-seq transcriptome data from different tissues in public databases revealed tissue-specific and differential expression profiles of the GmCBSDUFs, and qPCR analysis revealed that certain groups of soybean CBSDUFs are likely involved in specific stress responses. In addition, GmCBSDUF3 transgenic Arabidopsis was subjected to phenotypic analysis under NaCl, PEG, and ABA stress treatments. The overexpression of GmCBSDUF3 could enhance tolerance to drought and salt stress in Arabidopsis. This study presents a first comprehensive look at soybean CBSDUF proteins and provides valuable resources for functionally elucidating this protein subgroup within the CBS domain-containing protein family.

Interactions of the Cyanobacterium Chrysosporum ovalisporum with Antibiotics in Water - Jiahui Zhang; Shan Chen; Mingzhe Yuan; Wei Zhang; Houtao Xu; Xianyun Wang; Xiaoyan Zheng; Liqing Wang (Archives of Environmental Contamination and Toxicology, 2021)

Comprehensive evaluation of urban air quality using the relative entropy theory and improved TOPSIS method - Hong Lin; Tianhong Pan; Shan Chen (Air Quality, Atmosphere & Health, 2021)

Nitrogen in Atmospheric Wet Depositions Over the East Indian Ocean and West Pacific Ocean: Spatial Variability, Source Identification, and Potential Influences - Shan Jiang; Jie Jin; Shuo Jiang; Ying Wu; Jianing Wang; Ju Chen; Zhenqiu Zhang; Sumei Liu; Yan Chang; Lingyan Wang; Jing Zhang (Frontiers in Marine Science, 2021)
Atmospheric deposition is the dominant pathway for the loading of exogenous nitrogen (N) to open ocean. Here, rainwater samples were collected from 31 stations in the equatorial East Indian Ocean (EIO) and West Pacific Ocean (WPO) to explore the spatial variability of N species, potential sources, and related ecological influences. Among two oceans, nitrate (NO 3 – ) and ammonium (NH 4 + ) were the main components in the rainwater N inventory. NO 3 – concentrations varied from 0.19 to 100.5 μM, whereas NH 4 + concentrations ranged from 0.54 to 110.6 μM. Among all stations, low concentrations of NO 3 – and NH 4 + appeared in the remote ocean, whereas high concentrations were observed at the stations near the Malacca Strait and New Guinea, coupled with an enhancement of non-sea salt major ions, e.g., calcium ions (Ca 2+ ) and sulfate (SO 4 2– ), revealing the influence from coastal human activities, such as coal and gasoline combustion. In the remote ocean, δ 15 N–NH 4 + ranged from −5.7 to −9.3‰, whereas it dropped to -15.5‰ near coasts. A logarithmic decay between δ 15 N–NH 4 + and NH 4 + concentrations in rainwater samples was obtained, suggesting a shift from natural source (seawater emission) in oceanic precipitation events to anthropogenic source (chemical fertilizer volatilization and vehicle exhaust) in coastal rainwaters. δ 15 N–NO 3 – in the remote ocean varied between −1.7 and 0.4‰ with low levels found in the WPO, likely related to the ascending air flow driven by the Walker Circulation. In coastal oceans, δ 15 N–NO 3 – ranged from 1.5 to 3.5‰. The linkage between δ 15 N–NO 3 – and NO 3 – concentrations varied in two oceans, resulting from difference in biological and fossil fuel combustion contributions. Compared with ocean surface water, N in the rainwater was markedly enriched, suggesting that N from atmospheric wet depositions could rapidly enhance the dissolved N availability in ocean surface water. However, the N redundancy according to the Redfield–Brzezinski ratio (N:Si:P = 16:16:1) in the rainwater might benefit from the growth of N-preference phytoplankton species and microbes. As the first study on N concentrations, sources, and stoichiometry balance in rainwater over the equatorial WPO and EIO, the results could be a support to the global N budget estimation and oceanic primary production modeling.

A new quinolone alkaloid from the fruits of Tetradium ruticarpum - Chen Ma; Xiao Liu; Yu Shan; Shu Xu; Xu Feng; Qi-Zhi Wang (Natural Product Research, 2021)

Preparation, Characterization, and In Vitro Pharmacodynamics and Pharmacokinetics Evaluation of PEGylated Urolithin A Liposomes - Shengfu Yi; Cong Zhang; Junjie Hu; Yan Meng; Liang Chen; Huifan Yu; Shan Li; Guihong Wang; Guohua Zheng; Zhenpeng Qiu (AAPS PharmSciTech, 2021)

Multiple Hydropower Reservoirs Operation by Hyperbolic Grey Wolf Optimizer Based on Elitism Selection and Adaptive Mutation - Wen-jing Niu; Zhong-kai Feng; Shuai Liu; Yu-bin Chen; Yin-shan Xu; Jun Zhang (Water Resources Management, 2021)

The effect of aging on VEGF/VEGFR2 signal pathway genes expression in rat liver sinusoidal endothelial cell - Wan-Li Wang; Xing-Long Zheng; Qing-Shan Li; Wen-Yan Liu; Liang-Shuo Hu; Huan-Chen Sha; Kun Guo; Yi Lv; Bo Wang (Molecular and Cellular Biochemistry, 2021)

Alkaloids derived from the genus Daphniphyllum - Xu Liang; Xin-Zhou Yang; Lu Chen; Shan Jiang; Yu-Dan Chen; Qiao-Yu Deng; Xing-Guang Chen; Jing-Quan Yuan (Medicinal Chemistry Research, 2021)

Comparative genomic analysis of different virulence strains reveals reasons for the increased virulence of Aeromonas veronii - Bintong Yang; Chong Chen; Yufeng Sun; Linan Cao; Dongxing Zhang; Wuwen Sun; Lei Zhang; Guiqin Wang; Xiaofeng Shan; Yuanhuan Kang; Aidong Qian (Journal of Fish Diseases, 2021)
Aeromonas veronii is an important zoonotic and aquatic agent. More and more cases have shown that it has caused huge economic losses in the aquaculture industry in addition to threatening human health. But the reasons for the increasing virulence of A. veronii are still unclear. In order to further understand the reasons for the increased virulence of A. veronii , we conducted a comparative analysis of the genomes of A. veronii with different virulence. The analysis revealed that there are multiple virulence factors, such as those related to fimbriae, flagella, toxins, iron ion uptake systems and type II, type III and type VI secretion systems in the virulent strain TH0426 genome. And comparative analysis showed that there were two complete type III secretion systems (API1 and API2), of which the API2 and iron ion transport system were unique to the TH0426 strain. In addition, TH0426 strain also has unique functional gene clusters, which may play important roles in terms of resisting infection, adapting to different environments and genetic evolution. These particular virulence factors and gene clusters may be the important reasons for the increased virulence. These insights will provide a reference for the study of the pathogenesis of A. veronii .