Transcranial Direct-Current Stimulation Regulates MCT1-PPA-PTEN-LONP1 Signaling to Confer Neuroprotection After Rat Cerebral Ischemia–Reperfusion Injury - Xiangyi Kong; Wenjie Hu; Yu Cui; Jingchen Gao; Xujin Yao; Jinyang Ren; Tao Lin; Jiangdong Sun; Yunyi Gao; Xiaohua Li; Hui Wang; Huanting Li; et al. (Molecular Neurobiology, 2022)
Propionic acid (PPA) is a critical metabolite involved in microbial fermentation, which functions to reduce fat production, inhibit inflammation, and reduce serum cholesterol levels. The role of PPA in the context of cerebral ischemia–reperfusion (I/R) injury has yet to be clarified. Increasing evidence indicate that transcranial direct-current stimulation (tDCS) is a safe approach that confers neuroprotection in cerebral ischemia injury. Here, we show that the levels of PPA were reduced in the ischemic brain following a rat cerebral I/R injury and in the cultured rat cortical neurons after oxygen–glucose deprivation (OGD), an in vitro model of ischemic injury. We found that the decreased levels of transporter protein monocarboxylate transporter-1 (MCT1) were responsible for the OGD-induced reduction of PPA. Supplementing PPA reduced ischemia-induced neuronal death after I/R. Moreover, our results revealed that the neuroprotective effect of PPA is mediated through downregulation of phosphatase PTEN and subsequent upregulation of Lon protease 1 (LONP1). We demonstrated that direct-current stimulation (DCS) increased MCT1 expression and PPA level in OGD-insulted neurons, while tDCS decreased the brain infarct volume in the MCAO rats via increasing the levels of MCT1 expression and PPA. This study supports a potential application of tDCS in ischemic stroke.

Applying a deep residual network coupling with transfer learning for recyclable waste sorting - Kunsen Lin; Youcai Zhao; Xiaofeng Gao; Meilan Zhang; Chunlong Zhao; Lu Peng; Qian Zhang; Tao Zhou (Environmental Science and Pollution Research, 2022)

The association between essential trace element mixture and atherosclerotic cardiovascular disease risk among Chinese community-dwelling older adults - Xiang-long Meng; Yuan Wang; Hong-li Wang; Huan-huan Nie; Bei-jing Cheng; Hong-juan Cao; Xiu-de Li; Su-fang Wang; Gui-mei Chen; Fang-biao Tao; Jie Sheng; Lin-sheng Yang (Environmental Science and Pollution Research, 2022)

HIV-1 Tat drives the Fabp4/NF-κB feedback loop in microglia to mediate inflammatory response and neuronal apoptosis - Xiaodan Zhou; Shuhui Zhou; Jian Tao; Yanan Gao; Gaoqiang Meng; Duo Cao; Lin Gao (Journal of NeuroVirology, 2022)

Recent development in zebrafish model for bioactivity and safety evaluation of natural products - Fang-Jun Lin; Hang Li; Ding-Tao Wu; Qi-Guo Zhuang; Hua-Bin Li; Fang Geng; Ren-You Gan (Critical Reviews in Food Science and Nutrition, 2022)

7,8-Dihydroxyflavone attenuates the virulence of Staphylococcus aureus by inhibiting alpha-hemolysin - Nan Bian; Xiangqian Chen; Xinran Ren; Zishu Yu; Mengli Jin; Xiaoyu Chen; Chang Liu; Yanhe Luan; Lin Wei; Ying Chen; Wu Song; Yicheng Zhao; et al. (World Journal of Microbiology and Biotechnology, 2022)

Detection of the role of intestinal flora and tryptophan metabolism involved in antidepressant-like actions of crocetin based on a multi-omics approach - Susu Lin; Qiaoqiao Li; Zijin Xu; Ziwei Chen; Yi Tao; Yingpeng Tong; Ting Wang; Suhong Chen; Ping Wang (Psychopharmacology, 2022)

GDH promotes isoprenaline-induced cardiac hypertrophy by activating mTOR signaling via elevation of α-ketoglutarate level - Zhi-Rong Lin; Zhen-Zhen Li; Yan-Jun Cao; Wen-Jing Yu; Jian-Tao Ye; Pei-Qing Liu (Naunyn-Schmiedeberg's Archives of Pharmacology, 2022)

Incineration disposal of organic waste bio-residue via a deep dewatering process using refuse incineration bottom ash: moisture transfer and low calorific value improvement - Ran Wei; Ruina Zhang; Lijie Song; Xiong Zhou; Shunhong Lin; Youcai Zhao; Tao Zhou (Environmental Science and Pollution Research, 2022)

Two new physalins from Physalis alkekengi L. var. franchetii (Mast.) Makino - Jia-Min Sun; Ji-Xiang He; Min Huang; Hui-Xin Hu; Lin-Tao Xu; Kai-Li Fang; Xiao-Ning Wang; Tao Shen (Natural Product Research, 2022)

Coastal landscape pattern optimization based on the spatial distribution heterogeneity of ecological risk - Lin Yi; Sunjie Ma; Shiwei Tao; Jiyi Zhang; Jiujuan Wang (Frontiers in Marine Science, 2022)
The increasingly intensified development of coastal cities causes excessive consumption of natural resources, leading to environmental damage and increasing conflict between development and ecological protection. In addition to emphasizing ecological development, planners should pay more attention to the practical optimization and regulation of the developed landscape pattern. Taking Dafeng as an example, this study constructs a landscape-pattern optimization method suitable for the spatial distribution heterogeneity of ecological risk-level units in the coastal zone. The study is based on (a) an analysis of the composition and evolution characteristics of Dafeng’s coastal landscape elements, (b) the landscape pattern index of the ecosystem’s overall risk assessment, and (c) the minimal cumulative resistance (MCR) model. The study uses an ecosystem service value to build a resistance model by analyzing the medium and high-risk composition and distribution characteristics of space unit elements. Finally, 23 ecological sources, 14 ecological nodes, and 17 ecological corridors (total length 169.63 km) were built. The optimized coastal zone landscape pattern jointly protects the landscape area of high ecological value by 462.02 km 2 . The total ecological value is 105,01.71 million yuan. Landscape connectivity has been optimized, as well as the ecosystem’s stability and total service value. The optimization method proposed in this paper can reduce the protection area and cost. The spatial optimization unit is highly targeted, providing new ideas for the coastal cities to implement their ecological development and protection strategies.

Bifunctional Ni@NiO catalyst supported on loofah sponge-derived carbon for electrocatalytic air oxidation of biorefractory pollutant in a coupling system - Min Sun; Xiong-Fei Tao; Sheng-Nan Tang; Jun Yu; Yan Wang; Lin-Feng Zhai (Environmental Science and Pollution Research, 2022)

Risk evaluation and warning threshold of unstable slope using tilting sensor array - Lin Wang; Ichiro Seko; Makoto Fukuhara; Ikuo Towhata; Taro Uchimura; Shangning Tao (Natural Hazards, 2022)

HC-1119, a deuterated Enzalutamide, inhibits Migration, Invasion and Metastasis of the AR-positive triple-negative breast Cancer cells - Xuehong Wu; Wanru Feng; Mao Yang; Xunxi Liu; Mengdi Gao; Xinghai Li; Lin Gan; Tao He (Molecular Biology Reports, 2022)
Triple-negative breast cancers (TNBCs) are aggressive, and they develop metastasis at earlier stages, relapse more frequently, and exhibits poorer prognosis than other subtypes of breast cancer. Due to the lack of estrogen receptor for endocrine therapy and HER2 for targeted therapy, new targeted therapies for TNBCs are urgently needed. Enzalutamide is a second-generation androgen receptor (AR) inhibitor, and HC-1119 is a new synthetic deuterated enzalutamide. Owing to the isotope effect, HC-1119 has many advantages over enzalutamide, including slow metabolism, high plasma concentration and low brain exposure. However, the efficacy of HC-1119 in inhibition of AR function in triple-negative breast cancer (TNBC) has not been studied. In this study, we found high-level AR expression in both Hs578T and SUM159PT TNBC cell lines. Activation of AR by dihydrotestosterone (DHT) in both cell lines increased AR protein, induced AR-nuclear localization, enhanced cell migration and invasion in culture, and promoted liver metastasis in mice. Importantly, cotreatment with HC-1119 of these cells efficiently abolished all of these effects of DHT on both Hs578T and SUM159PT cells. These results indicate that HC-1119 is a very effective new second-generation AR antagonist that can inhibit the migration, invasion and metastasis of the AR-positive TNBC cells.

Fracture Mechanical Properties of Three—Dimensional Irregular Sandstone Particles Based on Digital-Image - Kai-wen Shi; Yu-jun Zuo; Wen-ji-bin Sun; Hao Liu; Jian-yun Lin; Tao-tao Li; Bin Chen; Lu-lin Zheng (Geotechnical and Geological Engineering, 2022)

Identification of a 5-gene-risk score model for predicting luminal A-invasive lobular breast cancer survival - Yi-Huan Chen; Tao-Feng Zhang; Yi-Yuan Liu; Jie-Hua Zheng; Wei-Xun Lin; Yao-Kun Chen; Jie-Hui Cai; Juan Zou; Zhi-Yang Li (Genetica, 2022)

How will Chinese cities reduce their carbon emissions? Evidence from spatial differences - Junna Yan; Zhonghua Zhang; Mingli Chen; Tao Lin; Ke Yuan (Environmental Science and Pollution Research, 2022)

Dynamic networks of P300-related process - Qin Tao; Lin Jiang; Fali Li; Yuan Qiu; Chanlin Yi; Yajing Si; Cunbo Li; Tao Zhang; Dezhong Yao; Peng Xu (Cognitive Neurodynamics, 2022)

Gregarious larval settlement mediates the responses of new recruits of the reef coral Acropora austera to ocean warming and acidification - Lei Jiang; Yu-Yang Zhang; Cheng-Yue Liu; Lin-Tao Huang; Hao-Ya Tong; Guo-Wei Zhou; Ming-Lan Guo; Tao Yuan; Hui Huang (Frontiers in Marine Science, 2022)
Gregarious larval settlement represents an important window for chimera formation in reef corals, yet it remains largely unknown how aggregated settlement and early chimerism could modify the performance and responses of coral recruits under elevated temperature and p CO 2 . In this study, single and aggregated recruits of the broadcast spawning coral Acropora austera were exposed to contrasts of two temperatures (28 versus 30.5°C) and p CO 2 levels (~500 versus 1000 μatm) for two weeks, and algal symbiont infection success, survivorship and growth were assessed. Results showed that symbiont infection success was mainly affected by temperature and recruit type, with reduced symbiont infection at increased temperature and consistently higher infection success in chimeric recruits compared to single recruits. Furthermore, although chimeric recruits with larger areal size had significantly higher survivorship in all treatments, the polyp-specific growth rates were considerably lower in chimeric entities than individual recruits. More importantly, the recruit type significantly influenced the responses of recruit polyp-specific growth rates to elevated temperature, with chimeras exhibiting lowered skeletal lateral growth under elevated temperature. These results demonstrate the benefits and costs associated with gregarious larval settlement for juvenile corals under ocean warming and acidification, and highlight the ecological role of larval settlement behavior in mediating the responses of coral recruits to climate change stressors.

Determining In-Situ Stress State by Anelastic Strain Recovery Method Beneath Xiamen: Implications for the Coastal Region of Southeastern China - Chongyuan Zhang; Weiren Lin; Manchao He; Zhigang Tao; Wen Meng (Rock Mechanics and Rock Engineering, 2022)

Insecticide resistance and its underlying synergism in field populations of Spodoptera frugiperda (J. E. Smith) from Hainan Island, China - Junbin Liu; Zheng Hao; Shengyuan Yang; Yuying Lin; Hao Zhong; Tao Jin (Phytoparasitica, 2022)

Activation of Dopamine D2 Receptors Alleviates Neuronal Hyperexcitability in the Lateral Entorhinal Cortex via Inhibition of HCN Current in a Rat Model of Chronic Inflammatory Pain - Shi-Hao Gao; Yong Tao; Yang Zhu; Hao Huang; Lin-Lin Shen; Chang-Yue Gao (Neuroscience Bulletin, 2022)

Extracellular histones induce inflammation and senescence of vascular smooth muscle cells by activating the AMPK/FOXO4 signaling pathway - Hang Yang; Yong-Yan Luo; Lue-Tao Zhang; Kai-Ran He; Xiao-Jun Lin (Inflammation Research, 2022)

Recyclable structured toxic industrial nickel-containing sludge for efficient anionic contaminant adsorption - Qiong Tian; Zhipeng Lin; Fengxian Qiu; Zhangdi Li; Qing Guo; Tao Zhang (Environmental Science and Pollution Research, 2022)

Geomechanics model test and numerical simulation of 2G-NPR bolt support effect in an active fault tunnel - Shu-lin Ren; Man-chao He; Wei-jun Lin; Teng-wu Zhang; Zhi-gang Tao (Journal of Mountain Science, 2022)

Effect of Zn2+-Cu2+ combined heavy metal on mechanical properties and microstructure of clayey soil - Qiang Ma; Nian-ze Wu; Heng-lin Xiao; Wen-tao Li; Jun-chen Xiang (Journal of Mountain Science, 2022)

Correction: Co-axial Projective Imaging for Augmented Reality Telementoring in Skin Cancer Surgery - Fan Zhang; Carlo M. Contreras; Pengfei Shao; Liping Zhao; Bingxuan Wu; Chenmeng Li; Tao Lin; Xiaohong Zhong; Zhongliang Lang; Peng Liu; Ronald X. Xu (Annals of Biomedical Engineering, 2022)

Climatology of aerosol types and their vertical distribution over East Asia based on CALIPSO lidar measurements - Lu Gui; Minghui Tao; Yi Wang; Lunche Wang; Liangfu Chen; Changqing Lin; Jinhua Tao; Jun Wang; Chao Yu (International Journal of Climatology, 2022)
Aerosol vertical distribution generally determines their health impacts and climate effects. By using long‐term (2007–2019) CALIPSO lidar measurements, we present a large‐scale insight into the climatology of aerosol types and their vertical structure over East Asia. Despite the low sampling frequency, comparison with MODIS aerosol optical depth (AOD) shows that the integrated CAIPSO vertical extinction can reasonably reproduce spatial patterns of the aerosol loading. With the unique advantage of active detection, CALIPSO reveals an obvious enhancement of the night‐time AOD due to worse diffusion conditions. Moreover, long‐range transport of different aerosols including dust, polluted dust, and smoke has substantial contribution to the aerosol loading over East Asia. Pure dust particles are mainly concentrated over the deserts with notable dust transport belts (dust AOD > 0.2 at 532 nm) along downwind regions during winter and spring. By contrast, polluted dust is prevalent over the downstream eastern China with much higher AODs throughout the year. In particular, AOD of polluted dust (~0.5) is higher in winter rather than in spring, which is consistent with their seasonal occurrences. Smoke aerosols usually appear in the night‐time over southern China. The top heights of aerosols are around 4–6 km, with dust and smoke having higher extinction at upstream regions. The climatology of these aerosol types and vertical distribution can provide a significant constraint for associated studies of air quality and climate effects.

PTEN-induced kinase 1 enhances the reparative effects of bone marrow mesenchymal stromal cells on mice with renal ischaemia/reperfusion-induced acute kidney injury - Chenyu Lin; Wen Chen; Yong Han; Yujie Sun; Xiaoqiong Zhao; Yuan Yue; Binyu Li; Wenmei Fan; Tao Zhang; Li Xiao (Human Cell, 2022)
Acute kidney injury (AKI) is a common severe acute syndrome caused by multiple factors and is characterized by a rapid decline in renal function during a short period. Bone marrow mesenchymal stromal cells (BMSCs) are effective in treating AKI. However, the mechanism of their beneficial effects remains unclear. PTEN-induced kinase 1 (PINK1) may play an important role in kidney tissue repair. In this study, we explored the effect of PINK1 overexpression on enhancing BMSC-mediated repair of AKI. In this study, ischaemia/reperfusion-induced AKI (IRI-AKI) in mice and a hypoxia-reoxygenation model in cells were established, and the indices were examined by pathology and immunology experiments. After ischaemia/reperfusion, PINK1 overexpression reduced apoptosis in injured kidney tissue cell, decreased T lymphocyte infiltration, increased macrophage infiltration, and alleviated the inflammatory response. PINK1 relieved the stress response of BMSCs and renal tubular epithelial cells (RTECs), reduced apoptosis, altered the release of inflammatory factors, and reduced the proliferation of peripheral blood mononuclear cells (PBMCs). In conclusion, BMSCs and RTECs undergo stress responses in response to hypoxia, inflammation and other conditions, and overexpressing PINK1 in BMSCs could enhance their ability to resist these stress reactions. Furthermore, PINK1 overexpression can regulate the distribution of immune cells and improve the inflammatory response. The regulation of mitochondrial autophagy during IRI-AKI maintains mitochondrial homeostasis and protects renal function. The results of this study provide new strategies and experimental evidence for BMSC-mediated repair of IRI-AKI.

Geochronology and geochemistry of the felsic-intermediate dikes from Xiangshan uranium ore field, South China: Implications for petrogenesis, tectonic setting and uranium mineralization - Yong-Jian Wang; Jiang-Tao Nie; Jin-Rong Lin; Hong-Zuo Wang (Mineralogy and Petrology, 2022)

Negative Poisson’s ratio and peripheral strain of an NPR anchor cable - Zhi-gang Tao; Hao-tian Xu; Shu-lin Ren; Long-ji Guo; Ke Qin; Yi-fei Zhu (Journal of Mountain Science, 2022)

LncRNA BACE1-AS promotes the progression of osteosarcoma through miR-762/SOX7 axis - Chunlei Wang; Tao Zhang; Lin Yang; Xinyu Na; Yanlong Qu (Molecular Biology Reports, 2022)

Transformation of HBCDs by Rhodococcus sp. stu-38 - Fei Yu; Wenqi Luo; Yuyang Li; Shanshan Meng; Xianbin Lin; Lele Li; Xueying Ye; Hui Wang; Tao Peng; Tongwang Huang; Zhong Hu (Current Microbiology, 2022)

Influence of asymmetric blockage of the drainage system of a deep-buried tunnel on water gushing - He-lin Fu; Peng-tao An; Yi-min Wu; Jie Li; Long Chen (Journal of Mountain Science, 2022)

Secretory phospholipase A2 group XIIBs play potential roles in intestine antibacterial responses in seahorse - Wanghong Xiao; Geng Qin; Yanhong Zhang; Bo Zhang; Tao Li; Zelin Chen; Qiang Lin (Journal of Fish Diseases, 2022)

Effects of micronized bamboo powder on growth performance, serum biochemical indexes, cecal chyme microflora and metabolism of broilers aged 1–22 days - Fawen Dai; Tao Lin; Lumin Cheng; Jian Wang; Jianjun Zuo; Dingyuan Feng (Tropical Animal Health and Production, 2022)
Adding insoluble fiber to diet of broilers has been reported to improve intestinal health and promote growth performance. Bamboo powder is a cheap raw material with rich insoluble fiber. This study aims to explore the effects of feeding micronized bamboo powder (MBP) on growth performance, serum biochemical indexes, intestinal microflora, and metabolism of broilers. A total of 1440 1-day-old slow-growing Ephedra chickens were randomly divided into three groups considering gender and body weight: (1) Group D: feeding with basal diet without antibiotics; (2) Group E: feeding with basal diet supplemented with 5% rice bran (RB); (3) Group F: feeding with basal diet supplemented with 1% MBP. Each group involved 8 replicates feeding for 22 days, with 60 chickens per replicate. Various indexes were detected. For the growth performance, the weight gain and feed consumption ratio (G: F) of Group F supplemented with MBP is 0.57 ± 0.04, which is significantly higher than that of E group supplemented with RB (0.52 ± 0.01, P < 0.05). For the serum biochemical indexes, the glutathione peroxidase activity in Group F is significantly higher than that of Group D, while the malondialdehyde content is significantly lower than that of Group D and Group E ( P < 0.05 for all). The fresh cecal chyme is taken for determination. In Group F, the α diversity index Faith_pd is significantly lower in Group F than that of Group D. The microorganism species in cecal chyme of Group F and Group E are also different. The metabolic pathways of Group F, mainly in fatty acid metabolism, amino acid metabolism and intestinal immune IgA production, were different from those of Group D and Group E. Adding 1% MBP to broiler diet can enhance the anti-oxidant capacity, improve chyme microflora, regulate the metabolism pathways responsible for intestinal fatty acids, amino acids, and immunity.

Characterization of Water Transport in Porous Building Materials Based on an Analytical Spontaneous Imbibition Model - Ming-Liang Qu; Sheng-Yue Lu; Qingyang Lin; Sajjad Foroughi; Zi-Tao Yu; Martin J. Blunt (Transport in Porous Media, 2022)

Sandstorms cause shrinkage of Haloxylon ammodendron shrubs and limit their self-renewal - Sheng-bo Shi; Dang-wei Zhou; Fang-lin Wang; Rui Shi; Tao Sun; Tian-cai Li; Jia-lin Ma; Xiang Wan; Jian-ping Ma; Jing-nian Tang (Theoretical and Experimental Plant Physiology, 2022)
Haloxylon ammodendron is an excellent windproof and sand-fixing species whose shrubs are widely cultivated in arid desert areas of northwest China but are now at risk of degradation and shrinkage. Using the chlorophyll fluorescence image analysis technique, the response of photosystem II (PSII) photochemical efficiency and non-photochemical quenching capacity to sediment-carrying wind and sand-free wind (both 12 m s −1 ) lasting for 10, 20, and 40 min were studied with seedlings in a wind tunnel. The results indicated that the sand-free wind had little influence on the maximum quantum efficiency of PSII photochemistry, F v / F m , which was approximately 0.80 on average; however, the F v / F m decreased over exposure time in the sediment-carrying wind group, with values smaller than those in the wind-only group. The non-photochemical quenching was sensitive to wind erosion, and sediment-carrying wind could aggravate the reduction in non-photochemical quenching ( NPQ ). Except for the 10 min duration, the maximum quantum efficiency of PSII photochemistry after dark recovery for 15 min, F v r / F m r , was lower in seedlings exposed to sediment-carrying wind than in those in the wind-only group. Compared to wind-only, wind-blown sand led to a water imbalance and withering in seedlings, causing the concentration of photosynthetic pigments (when based on the fresh mass of green branches) to not decrease. With a longer exposure time to sediment-carrying wind, both the probability and extent of lignified spots occurring increased in green assimilative branches. Our results demonstrated that sediment-carrying wind at 12 m s −1 lasting for 20 min or more could cause irreversible damage to the photosynthetic apparatus of H. ammodendron seedlings. Therefore, frequent and strong sandstorms are the main disturbance factors leading to shrinkage of shrubs and limiting their self-renewal.

Chaperone-mediated Autophagy Regulates Cell Growth by Targeting SMAD3 in Glioma - Hanqun Liu; Yuxuan Yong; Xingjian Li; Panghai Ye; Kai Tao; Guoyou Peng; Mingshu Mo; Wenyuan Guo; Xiang Chen; Yangfu Luo; Yuwan Lin; Jiewen Qiu; et al. (Neuroscience Bulletin, 2022)

Diagnostic Performance of miR-485-3p in Patients with Parkinson’s Disease and its Relationship with Neuroinflammation - Xia Lin; Rui Wang; Ran Li; Taotao Tao; Danhong Zhang; Yuxiang Qi (NeuroMolecular Medicine, 2022)

Environmental risks and the potential benefits of nanopesticides: a review - Zhenlan Xu; Tao Tang; Qin Lin; Jianzhong Yu; Changpeng Zhang; Xueping Zhao; Melanie Kah; Lingxiangyu Li (Environmental Chemistry Letters, 2022)

Basement excavation influences zones for deformation of the adjacent side tunnel - Shengfeng Huang; Zhibo Chen; Tao Jiang; Yongning Xie; Zhiyuan Lin; Yuchen Deng (Arabian Journal of Geosciences, 2022)

Comparison of different inversion methods of D-T2 two-dimensional nuclear magnetic resonance logging and applicability analysis - Cheng-Lin Li; Mao-Jin Tan; Ke-Wen Wang; Feng Zhou; Ying-Ming Liu; Hai-Tao Zhang; Li-Zhi Xiao (Applied Geophysics, 2022)

Massive Heat Shock Protein 70 Genes Expansion and Transcriptional Signatures Uncover Hard Clam Adaptations to Heat and Hypoxia - Zhi Hu; Hao Song; Jie Feng; Cong Zhou; Mei-Jie Yang; Pu Shi; Zheng-Lin Yu; Yong-Ren Li; Yong-Jun Guo; Hai-Zhou Li; Tao Zhang (Frontiers in Marine Science, 2022)
Heat shock protein 70 (HSP70) members participate in a wide range of housekeeping and stress-related activities in eukaryotic cells. In marine ecosystems, bivalves encounter abiotic stresses, including high temperatures and low dissolved oxygen. Here, 133 MmHSP70 genes were identified through combined methods including Blastp, HMM and manual filtration, based on the whole Mercenaria mercenaria genome. The MmHSP70 genes were unevenly distributed, and 41 genes (33.08%) were located on Chr 7. Phylogenetic analyses indicated that the MmHSP70 gene family mainly consisted of two clusters and the Hspa12 subfamily underwent lineage-specific expansion. A high-density collinear gene block was observed between M. mercenaria Chr 7 and Cyclina sinensis Chr 14. Tandem duplication MmHSP70 gene pairs experienced different levels of purifying selection, which could be an important source of sequence and functional constraints. MmHSP70 genes showed tissue-specific and stress-specific expression. Most tandem duplication HSP70 gene pairs had high expression under hypoxia stress. HSP70 B2 tandem duplication gene pairs showed significantly increased expression under heat plus severe hypoxia stress. This study provided a comprehensive understanding of the MmHSP70 gene family in the M. mercenaria and laid a significant foundation for further studies on the functional characteristics of MmHSP70 genes during exposure to heat and hypoxia stress.

Complete genome sequence of a novel chlorobenzene degrader, Burkholderia stabilis TF-2 - Xiao-Ping Zhang; Yan-Hui Gao; Zhi-Lin Xing; Yong-Qiong Wang; Tian-Tao Zhao (Biologia, 2022)

A New Non-stationary Hydrological Drought Index Encompassing Climate Indices and Modified Reservoir Index as Covariates - Youxin Wang; Tao Peng; Qingxia Lin; Vijay P. Singh; Xiaohua Dong; Chen Chen; Ji Liu; Wenjuan Chang; Gaoxu Wang (Water Resources Management, 2022)

Effects of Involuntary and Voluntary Exercise in Combination with Acousto-Optic Stimulation on Adult Neurogenesis in an Alzheimer's Mouse Model - Wan-yi Li; Jun-yan Gao; Su-Yang Lin; Shao-tao Pan; Biao Xiao; Yu-tao Ma; Kai Xie; Wei Shen; Zhi-tao Liu; Guang-yu Li; Jie-jie Guo; Qin-wen Wang; et al. (Molecular Neurobiology, 2022)

Interleukin-13 Affects the Recovery Processes in a Mouse Model of Hemorrhagic Stroke with Bilateral Tibial Fracture - Ya’nan Yan; Cheng Gao; Guang Chen; Xueshi Chen; Yanglin Wu; Heng Xu; Zhiqi Cheng; Chengliang Luo; Mingyang Zhang; Tao Wang; Jun Lin; Xiping Chen; et al. (Molecular Neurobiology, 2022)

Metabolic tuning of a stable microbial community in the surface oligotrophic Indian Ocean revealed by integrated meta-omics - Zhang-Xian Xie; Ke-Qiang Yan; Ling-Fen Kong; Ying-Bao Gai; Tao Jin; Yan-Bin He; Ya-Yu Wang; Feng Chen; Lin Lin; Zhi-Long Lin; Hong-Kai Xu; Zong-Ze Shao; et al. (Marine Life Science & Technology, 2022)
Understanding the mechanisms, structuring microbial communities in oligotrophic ocean surface waters remains a major ecological endeavor. Functional redundancy and metabolic tuning are two mechanisms that have been proposed to shape microbial response to environmental forcing. However, little is known about their roles in the oligotrophic surface ocean due to less integrative characterization of community taxonomy and function. Here, we applied an integrated meta-omics-based approach, from genes to proteins, to investigate the microbial community of the oligotrophic northern Indian Ocean. Insignificant spatial variabilities of both genomic and proteomic compositions indicated a stable microbial community that was dominated by Prochlorococcus , Synechococcus , and SAR11. However, fine tuning of some metabolic functions that are mainly driven by salinity and temperature was observed. Intriguingly, a tuning divergence occurred between metabolic potential and activity in response to different environmental perturbations. Our results indicate that metabolic tuning is an important mechanism for sustaining the stability of microbial communities in oligotrophic oceans. In addition, integrated meta-omics provides a powerful tool to comprehensively understand microbial behavior and function in the ocean.

Community structure and assembly of denitrifying bacteria in epiphytic biofilms in a freshwater lake ecosystem - Guoqing Li; Dingbo Yan; Pinhua Xia; Haipeng Cao; Tao Lin; Yin Yi (Journal of Oceanology and Limnology, 2022)

Identification of PDXDC1 as a novel pleiotropic susceptibility locus shared between lumbar spine bone mineral density and birth weight - Yu-Qian Song; Shi-Di Hu; Xu Lin; Xiang-He Meng; Xiao Wang; Yin-Hua Zhang; Cheng Peng; Rui Gong; Tao Xu; Tong Zhang; Chen-Zhong Li; Dao-Yan Pan; et al. (Journal of Molecular Medicine, 2022)
An increasing number of epidemiological studies have suggested that birth weight (BW) may be a determinant of bone health later in life, although the underlying genetic mechanism remains unclear. Here, we applied a pleiotropic conditional false discovery rate (cFDR) approach to the genome-wide association study (GWAS) summary statistics for lumbar spine bone mineral density (LS BMD) and BW, aiming to identify novel susceptibility variants shared between these two traits. We detected 5 novel potential pleiotropic loci which are located at or near 7 different genes ( NTAN1 , PDXDC1 , CACNA1G , JAG1 , FAT1P1 , CCDC170 , ESR1 ), among which PDXDC1 and FAT1P1 have not previously been linked to these phenotypes. To partially validate the findings, we demonstrated that the expression of PDXDC1 was dramatically reduced in ovariectomized (OVX) mice in comparison with sham-operated (SHAM) mice in both the growth plate and trabecula bone. Furthermore, immunohistochemistry assay with serial sections showed that both osteoclasts and osteoblasts express PDXDC1 , supporting its potential role in bone metabolism. In conclusion, our study provides insights into some shared genetic mechanisms for BMD and BW as well as a novel potential therapeutic target for the prevention of OP in the early stages of the disease development. Key messages We investigated pleiotropy-informed enrichment between LS BMD and BW. We identified genetic variants related to both LS BMD and BW by utilizing a cFDR approach. PDXDC1 is a novel pleiotropic gene which may be related to both LS BMD and BW. Elevated expression of PDXDC1 is related to higher BMD and lower ratio n-6/n-3 PUFA indicating a bone protective effect of PDXDC1.

Insight into the dynamic microbial community and core bacteria in composting from different sources by advanced bioinformatics methods - Yabin Zhan; Yuan Chang; Yueyue Tao; Hao Zhang; Yongfeng Lin; Jie Deng; Tiantian Ma; Guochun Ding; Yuquan Wei; Ji Li (Environmental Science and Pollution Research, 2022)

TRIP13 knockdown inhibits the proliferation, migration, invasion, and promotes apoptosis by suppressing PI3K/AKT signaling pathway in U2OS cells - De-Chen Yu; Xiang-Yi Chen; Hai-Yu Zhou; De-Quan Yu; Xiao-Lei Yu; Yi-Cun Hu; Rui-Hao Zhang; Xiao-Bo Zhang; Kun Zhang; Mao-Qiang Lin; Xi-Dan Gao; Tao-Wen Guo (Molecular Biology Reports, 2022)

Associations of air pollutants with pneumonia hospital admissions in Qingdao, China: a prospective cohort study - Hai-Tao Wang; Hong Zhang; Fu-Zhong Xue; Lin Zhao; Wu-Chun Cao (Environmental Science and Pollution Research, 2022)

Production of sesquiterpene patchoulol in mitochondrion-engineered Saccharomyces cerevisiae - Xin-Yi Tao; Yang-Chen Lin; Feng-Qing Wang; Qing-Hai Liu; Yu-Shu Ma; Min Liu; Dong-Zhi Wei (Biotechnology Letters, 2022)

Taxonomy and Phylogeny of Two Tintinnid Ciliates of Leprotintinnus (Protista, Ciliophora, Choreotrichida) Combining the Loricae, Cytological, Ontogenetic Features, and Barcoding Genes - Tao Hu; Zhaoyi Wang; Weiwei Liu; Xiaofeng Lin (Frontiers in Marine Science, 2022)
Tintinnid ciliates are a highly diverse and essential group in the marine planktonic microbial loop. However, most of the known tintinnids were recorded only by the lorica characters and very few of them had been studied on their cytological features. In this study, the morphological characters of the lorica, ciliary pattern, nuclear apparatus, ontogenesis, and the molecular phylogeny of two poorly known tintinnid ciliates, Leprotintinnus nordqvisti ( Brandt, 1906 ) Kofoid and Campbell (1929) and L. simplex Schmidt (1902) , isolated from coastal waters of southern China, were investigated based on living observation, silver staining, three nuclear ribosomal DNA markers (18S, ITS1-5.8S-ITS2, and 28S genes) and one mitochondrial DNA marker ( CO1 gene). For the first time, the somatic ciliary pattern of the genus Leprotintinnus was disclosed, viz ., comprising a ventral, a dorsal, and a posterior kinety as well as a right, a left, and a lateral ciliary field. The diagnoses of both Leprotintinnus species were improved and the neotype was assigned. The ontogenesis of L. nordqvisti was in enantiotropic division mode with the new dorsal and posterior kineties generated de novo . The molecular phylogeny confirmed that Leprotintinnus species are closely related to some species of Tintinnopsis , Stylicauda , Rhizodomus , and Climacocylis . The anterior extending of the ventral kinety together with some of the lateral kinety is likely to be a distinguishing feature to determine their systematic relationships. This study also revealed that (i) the lorica of L. nordqvisti is polymorphic or plastic; (ii) Leprotintinnus tubulosus Roxas (1941) might be a synonym of L . nordqvisti ; (iii) Leprotintinnus neriticus sensu Yoo et al. (1988) might be a misidentification of L. simplex .

Extensive sequence divergence between the reference genomes of Taraxacum kok-saghyz and Taraxacum mongolicum - Tao Lin; Xia Xu; Huilong Du; Xiuli Fan; Qingwen Chen; Chunyan Hai; Zijian Zhou; Xiao Su; Liquan Kou; Qiang Gao; Lingwei Deng; Jinsheng Jiang; et al. (Science China Life Sciences, 2022)

Contrasting effects of plant-soil feedbacks on growth and morphology of physically-connected daughter and mother ramets in two clonal plants - Wei Xue; Lin Huang; Wei-Jia Sheng; Jia-Tao Zhu; Shu-Qi Li; Fei-Hai Yu (Plant and Soil, 2022)

A Review of Parallel Implementations for the Smith–Waterman Algorithm - Zeyu Xia; Yingbo Cui; Ang Zhang; Tao Tang; Lin Peng; Chun Huang; Canqun Yang; Xiangke Liao (Interdisciplinary Sciences: Computational Life Sciences, 2022)

Can transportation infrastructure reduce haze pollution in China? - Chenggang Li; Tao Lin; Zhifei Zhang; Dan Xu; Lei Huang; Wanping Bai (Environmental Science and Pollution Research, 2022)

Sphingobacterium bovistauri sp. nov., Isolated from the Faeces of Bos Taurus - Qiong Wang; Zhi-Qin Fang; Chen-Lu Zhang; Jian-Qiang Shen; Jian-Dong Lai; Xiu-Lin Han; Tao Lu (Current Microbiology, 2022)

Selenium Deficiency Leads to Changes in Renal Fibrosis Marker Proteins and Wnt/β-Catenin Signaling Pathway Components - Tingting Lin; Jiaqi Tao; Ying Chen; Yitong Zhang; Fenglan Li; Yutong Zhang; Xueqing Han; Zihui Zhao; Guiyan Liu; Hui Li (Biological Trace Element Research, 2022)

Numerical Simulation of Mine Water Inflow with an Embedded Discrete Fracture Model: Application to the 16112 Working Face in the Binhu Coal Mine, China - Tao Chen; Huiyong Yin; Yutao Zhai; Lin Xu; Cuiyue Zhao; Lifeng Zhang (Mine Water and the Environment, 2022)

Stability and deformation of Xiaozhuang landslide: A large-scale creeping landslide in Gansu, China - Ze-lin Zhang; Tao Wang (Journal of Mountain Science, 2022)

Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis - Jie Luo; Zhimin Song; Tao Zhang; Ketan Chu; Jingyi Li; Jianhong Zhou; Jun Lin (Journal of Zhejiang University-SCIENCE B, 2022)

Research on cropping intensity mapping of the Huai River Basin (China) based on multi-source remote sensing data fusion - Yihang Wang; Lin Fan; Ranting Tao; Letao Zhang; Wei Zhao (Environmental Science and Pollution Research, 2022)

Different effects of the DRD4 genotype on intrinsic brain network connectivity strength in drug-naïve children with ADHD and healthy controls - Shuangli Chen; Andan Qian; Jiejie Tao; Ronghui Zhou; Chuqi Fu; Chuang Yang; Qingxia Lin; JieJie Zhou; Jiance Li; Xiaoqi Huang; Meihao Wang (Brain Imaging and Behavior, 2022)
The dopamine D4 receptor gene (DRD4) has been consistently reported to be associated with attention-deficit/hyperactivity disorder (ADHD). Recent studies have linked DRD4 to functional connectivity among specific brain regions. The current study aimed to compare the effects of the DRD4 genotype on functional integrity in drug-naïve ADHD children and healthy children. Resting-state functional MRI images were acquired from 49 children with ADHD and 37 healthy controls (HCs). We investigated the effects of the 2-repeat allele of DRD4 on brain network connectivity in both groups using a parameter called the degree of centrality (DC), which indexes local functional relationships across the entire brain connectome. A voxel-wise two-way ANCOVA was performed to examine the diagnosis-by-genotype interactions on DC maps. Significant diagnosis-by-genotype interactions with DC were found in the temporal lobe, including the left inferior temporal gyrus (ITG) and bilateral middle temporal gyrus (MTG) (GRF corrected at voxel level p < 0.001 and cluster level p < 0.05, two-tailed). With the further subdivision of the DC network according to anatomical distance, additional brain regions with significant interactions were found in the long-range DC network, including the left superior parietal gyrus (SPG) and right middle frontal gyrus (MFG). The post-hoc pairwise analysis found that altered network centrality related to DRD4 differed according to diagnostic status (p < 0.05). This genetic imaging study suggests that the DRD4 genotype regulates the functional integration of brain networks in children with ADHD and HCs differently. This may have important implications for our understanding of the role of DRD4 in altering functional connectivity in ADHD subjects.

Advenella mandrilli sp. nov., a bacterium isolated from the faeces of Mandrillus sphinx - Qiong Wang; Xiu-Lin Han; Zhi-Qin Fang; Chen-Lu Zhang; Chun Li; Tao Lu (Antonie van Leeuwenhoek, 2022)

Highly selective monoclonal antibody-based lateral flow immunoassay for visual and sensitive determination of conazole fungicides propiconazole in vegetables - Ze-Ke Xu; Jing-Nan Meng; Yi Lei; Xing-Xing Yang; Yi-Yong Yan; Hai-Hong Liu; Hong-Tao Lei; Ting-Cai Wang; Xing Shen; Zhen-Lin Xu (Food Additives & Contaminants: Part A, 2022)

Adenine base-editing-mediated exon skipping induces gene knockout in cultured pig cells - Xiang-xing Zhu; Jia-sheng Pan; Tao Lin; Ye-cheng Yang; Qiu-yan Huang; Shuai-peng Yang; Zi-xiao Qu; Zi-sheng Lin; Jian-cong Wen; Ai-fen Yan; Juan Feng; Lian Liu; et al. (Biotechnology Letters, 2022)

A novel alphahypovirus that infects the fungal plant pathogen Sclerotinia sclerotiorum - Weibo Liang; Zhongbo Lu; Jie Duan; Daohong Jiang; Jiatao Xie; Jiasen Cheng; Yanping Fu; Tao Chen; Bo Li; Xiao Yu; Weidong Chen; Yang Lin (Archives of Virology, 2022)

210Po-210Pb Disequilibrium in the Western North Pacific Ocean: Particle Cycling and POC Export - Qiangqiang Zhong; Tao Yu; Hui Lin; Jing Lin; Jianda Ji; Jialin Ni; Jinzhou Du; Dekun Huang (Frontiers in Marine Science, 2021)
Estimating the particulate organic carbon (POC) export flux from the upper ocean is fundamental for understanding the efficiency of the biological carbon pump driven by sinking particles in the oceans. The downward POC flux from the surface ocean based on 210 Po- 210 Pb disequilibria in seawater samples from the western North Pacific Ocean (w-NPO) was measured in the early summer (May-June) of 2018. All the profiles showed a large 210 Po deficiency relative to 210 Pb in the euphotic zone (0–150 m), while this 210 Po deficiency vanished below ∼500 m (with 210 Po/ 210 Pb ∼1 or > 1). A one-dimensional steady-state irreversible scavenging model was used to quantify the scavenging and removal fluxes of 210 Po and 210 Pb in the euphotic zone of the w-NPO. In the upper ocean (0–150 m), dissolved 210 Po (D-Po) was scavenged into particles with a residence time of 0.6–5.5 year, and the 210 Po export flux out of the euphotic zone was estimated as (0.33–3.49) × 10 4 dpm/m 2 /year, resulting in a wide range of particulate 210 Po (P-Po) residence times (83–921 days). However, in the deep ocean (150–1,000 m), 210 Po was transferred from the particulate phase to the dissolved phase. Using an integrated POC inventory and the P-Po residence times (Eppley model) in the w-NPO euphotic zone, the POC export fluxes (mmol C/m 2 /d) varied from 0.6 ± 0.2 to 8.8 ± 0.4. In comparison, applying the POC/ 210 Po ratio of all (>0.45 μm) particles to 210 Po export flux (Buesseler model), the obtained POC export fluxes (mmol C/m 2 /d) ranged from 0.7 ± 0.1 to 8.6 ± 0.8. Both Buesseler and Eppley methods showed enhanced POC export fluxes at stations near the continental shelf (i.e., Luzon Strait and the Oyashio-Kuroshio mixing region). The Eppley model-based 210 Po-derived POC fluxes agreed well with the Buesseler model-based fluxes, indicating that both models are suitable for assessing POC fluxes in the w-NPO. The POC export efficiency was < 15%, suggesting a moderate biological carbon pump efficiency in the w-NPO. These low export efficiencies may be associated with the dominance of smaller particles and the processes of degradation and subsequent remineralization of these small particles in the euphotic zone of oligotrophic regions in the w-NPO.

Hotter and drier climate made the Mediterranean Europe and Northern Africa region a shrubbier landscape - Wei Fang; Chuixiang Yi; Deliang Chen; Peipei Xu; George Hendrey; Nir Krakauer; Katherine Jensen; Shan Gao; Zihan Lin; Gabriella Lam; Qin Zhang; Tao Zhou (Oecologia, 2021)

M1 macrophages-derived exosomes miR-34c-5p regulates interstitial cells of Cajal through targeting SCF - Su Xu; Jinhai Zhai; Ke Xu; Xingguo Zuo; Chenghua Wu; Tao Lin; Li Zeng (Journal of Biosciences, 2021)

Experimental study on the discharge characteristics of viscous debris flow with grid-type dam - Jinfeng Liu; Dong Yuan; Ming Lu; Yong You; Guangze Zhang; Tao Feng; Dong Wang; Zhiheng Lin (Environmental Fluid Mechanics, 2021)

The Therapeutic Role of Slit2 in Anti-fibrosis, Anti-inflammation and Anti-oxidative Stress in Rats with Coronary Heart Disease - Ji-Wei Liu; Hai-Tao Liu; Lin Chen (Cardiovascular Toxicology, 2021)

Evolution of pore structure in organic shale with type III kerogen and high kaolinite content in Ningwu Basin - Qiang Xu; Hangbing Lin; Yue Zhao; Bo Wang; Bin Ma; Rong Ding; Jianxin Wang; Tao Hou (Frontiers of Earth Science, 2021)

Correction to: 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Bernard R. Agwanda; Rim Al Kubrusli; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Christopher F. Basler; et al. (Archives of Virology, 2021)

2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Bernard R. Agwanda; Rim Al Kubrusli; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Christopher F. Basler; et al. (Archives of Virology, 2021)

A New Instrumental Array in Sichuan, China, to Monitor Vibrations and Perturbations of the Lithosphere, Atmosphere, and Ionosphere - Chieh-Hung Chen; Yang-Yi Sun; Kai Lin; Chen Zhou; Rui Xu; Haiyin Qing; Yongxin Gao; Tao Chen; Fei Wang; Huaizhong Yu; Peng Han; Chi-Chia Tang; et al. (Surveys in Geophysics, 2021)

Fouling characteristics of cnidarians (Hydrozoa and Anthozoa) along the coast of China - Tao Yan; Mingqing Lin; Wenhao Cao; Shuaishuai Han; Xikun Song (Journal of Oceanology and Limnology, 2021)

Oceanic vertical mixing of the lower halocline water in the Chukchi Borderland and Mendeleyev Ridge - Long Lin; Hailun He; Yong Cao; Tao Li; Yilin Liu; Mingfeng Wang (Acta Oceanologica Sinica, 2021)

Late Cretaceous adakitic rocks from the western Tibetan Plateau: implications for the subduction of the Neo-Tethys Ocean - Wei Wang; Qing-Guo Zhai; Pei-Yuan Hu; Sun-Lin Chung; Yue Tang; Hai-Tao Wang; Zhi-Cai Zhu; Hao Wu; Zhi-Qiang Huang (International Geology Review, 2021)

Complement C3 Aggravates Post-epileptic Neuronal Injury Via Activation of TRPV1 - Guang-Tong Jiang; Lin Shao; Shuo Kong; Meng-Liu Zeng; Jing-Jing Cheng; Tao-Xiang Chen; Song Han; Jun Yin; Wan-Hong Liu; Xiao-Hua He; Yu-Min Liu; Lanzi Gongga; et al. (Neuroscience Bulletin, 2021)

Effects of a compound microbial agent and plants on soil properties, enzyme activities, and bacterial composition of Pisha sandstone - Lin Deng; Tao Wang; Wei Luo; Linyan He; Zhishui Liang (Environmental Science and Pollution Research, 2021)

Degraded polysaccharides from Porphyra haitanensis: purification, physico-chemical properties, antioxidant and immunomodulatory activities - Yun-Feng Huo; Yin-Ting Li; Wei Xia; Chong Wang; Yuan-Yuan Xie; Yan-Bo Wang; Tao Zhou; Ling-Lin Fu (Glycoconjugate Journal, 2021)

Health risk assessment of heavy metals in soils and screening of accumulating plants around the Wanshan mercury mine in Northeast Guizhou Province, China - Xiangchen Tang; Xianliang Wu; Pinhua Xia; Tao Lin; Xianfei Huang; Zhenming Zhang; Jiachun Zhang (Environmental Science and Pollution Research, 2021)

Neuroanatomical correlates of self-awareness of highly practiced visuomotor skills - Junjun Li; Zhenglong Lin; Ran Tao; Min Xu; Shihong Kong; Hong-Yan Bi; Yang Yang (Brain Structure and Function, 2021)

Sphingobacterium rhinopitheci sp. Nov., isolated from the faeces of Rhinopithecus bieti in China - Xiu-Lin Han; Qiong Wang; Chen-Lu Zhang; Zhi-Qin Fang; Jian-Qiang Shen; Song Huang; Tao Lu (Archives of Microbiology, 2021)

Assessment of climate change effects on alpine summit vegetation in the transition of tropical to subtropical humid climate - Chu-Chia Kuo; Yu Su; Ho-Yih Liu; Cheng-Tao Lin (Plant Ecology, 2021)

Synthesis and biological evaluation of novel 1,3-diphenylurea quinoxaline derivatives as potent anticancer agents - Gui-Zhen Li; Xi-Lin Ouyang; Zu-Yu Mo; Yao Gu; Xiao-Lin Cao; Li Yang; Hai-Tao Tang; Ying-Ming Pan (Medicinal Chemistry Research, 2021)

Using stratified Bayesian model averaging in probabilistic forecasts of precipitation over the middle and lower Yangtze River region - Haixia Qi; Xiefei Zhi; Tao Peng; YongQing Bai; Chunze Lin; Wen Chen (Meteorology and Atmospheric Physics, 2021)

Comparative Transcriptome Analysis of Heart Tissue in Response to Hypoxia in Silver Sillago (Sillago sihama) - Wanida Saetan; Minghui Ye; Xinghua Lin; Xiaozhan Lin; Yulei Zhang; Yang Huang; Tao Du; Guangli Li; Changxu Tian (Journal of Ocean University of China, 2021)

The Characteristic of Critical Genes in Neuroendocrine System and Their Regulation on Food Habit Transition and Metamorphosis of Veined Rapa Whelk Rapana venosa (Valenciennes, 1846) - Mei-Jie Yang; Jie Feng; Hao Song; Zheng-Lin Yu; Pu Shi; Jian Liang; Zhi Hu; Cong Zhou; Xiao-Lin Wang; Tao Zhang (Frontiers in Marine Science, 2021)
Metamorphosis is a critical developmental event in mollusks, and neuroendocrine system plays an essential role in this process. Rapana venosa is an economically important shellfish in China, but the artificial technology of R. venosa aquaculture is limited by metamorphosis. As a carnivorous gastropod, food habit transition makes the mechanism of R. venosa metamorphosis more complex. To investigate the changes in the neuroendocrine system and to reveal its role in regulating the food habit transition and metamorphosis of R. venosa , we cloned the cDNA sequences encoding 5-hydroxytryptamine receptor ( Rv-5HTR ), nitric oxide synthetase ( Rv-NOS ) and cholecystokinin receptor ( Rv-CCKR ), and investigated their expression by quantitative real-time PCR analysis, and explore the spatio-temporal changes of 5-HT protein expression using Immunohistochemical (IHC) analysis. The expression of the three geens was significantly increased in the early intramembrane veliger stage, which indicates that the three genes are related to the development of digestive system. Additionally, expression of the three genes was decreased after metamorphosis, while Rv-NOS and Rv-CCKR were increasingly expressed in competent larvae, which may help the larvae find suitable environments and promote digestive system development for metamorphosis, and the result of 5-HT IHC analysis also reflects the development of neuroendocrine system. Furthermore, results show that CCK can effect the expression of digestive enzyme, NOS and 5-HT receptor. Finally, based on the present results, we hypothesized that CCK and CCK receptor may be critical regulatory factors of food habit transition and metamorphosis. These results might provide information on the development of neuroendocrine system of R. venosa , and new insight into the regulation of the food habit transition and metamorphosis of gastropods.

Nanoemulgel for Improved Topical Delivery of Desonide: Formulation Design and Characterization - Qiuyan Ma; Jing Zhang; Bohong Lu; Huaqing Lin; Rajib Sarkar; Tao Wu; Xuee Li (AAPS PharmSciTech, 2021)

Al-PHOSLOCK thin-layer capping to control phosphorus release from sediment: effect of hydraulic retention time and phosphorus migration/transformation mechanism - Canyang Lin; Shuwen Li; Bolin Zhu; Shupo Liu; Fei Li; Zhenming Zhou; Tao Li (Journal of Soils and Sediments, 2021)

Research on temporal and spatial variations in the degree of coupling coordination of tourism–urbanization–ecological environment: a case study of Heilongjiang, China - Tao Zhang; Lin Li (Environment, Development and Sustainability, 2021)

Detection of Human Sapoviruses in Sewage in China by Next Generation Sequencing - Ke Song; Xiaojuan Lin; Yao Liu; Feng Ji; Li Zhang; Peng Chen; Chenxu Zhao; Yanyan Song; Zexin Tao; Aiqiang Xu (Food and Environmental Virology, 2021)

The resurgent landscape of xenotransplantation of pig organs in nonhuman primates - Xuan Zhang; Quancheng Wang; Jingjun Zhao; Xiao Li; Wei Peng; Zhaoxu Yang; Zhibin Lin; Long Yang; Rui Ding; Kaishan Tao; Kefeng Dou (Science China Life Sciences, 2021)

Identification of miRNA targets in eggplant in response to Verticillium dahliae by degradome sequencing - Ting Li; Nianjiao Tao; Yuanmi Lin; Min Chen; Dongli Jiao; Chunmei Xue; Wenjiao Zhu; Qing Yang (European Journal of Plant Pathology, 2021)

Impact factors of the accumulation, migration and spread of antibiotic resistance in the environment - Zibo Lin; Tao Yuan; Lai Zhou; Sen Cheng; Xu Qu; Ping Lu; Qiyan Feng (Environmental Geochemistry and Health, 2021)

The Effects of Installation on the Elastic Stiffness Coefficients of Spudcan Foundations - Wen-Long Lin; Zhen Wang; Fei Liu; Jiang-Tao Yi (Journal of Marine Science and Engineering, 2021)
Subjected to pre-load, spudcan foundations, widely utilized to support offshore jack-up rigs, may penetrate in a few diameters into soft clays before mobilizing sufficient resistance from soil. While its stress–strain behavior is known to be affected by the embedment condition and soil backflow, the small-strain calculation with wished-in-place assumption was previously adopted to analyze its elastic stiffness coefficients. This study takes advantage of a recently developed dual-stage Eulerian–Lagrangian (DSEL) technique to re-evaluate the elastic stiffness coefficients of spudcans after realistically modelling the deep, continuous spudcan penetration. A numerical parametric exercise is conducted to investigate the effects of strength non-homogeneity, embedment depths, and the spudcan’s size on the elastic stiffness. On these bases, an expression is provided such that the practicing engineers can conveniently factor the installation effects into the estimation of elastic stiffness coefficients of spudcans.

Mortality burden caused by diurnal temperature range: a nationwide time-series study in 364 Chinese locations - Min Cai; Jianxiong Hu; Chunliang Zhou; Zhulin Hou; Yanjun Xu; Maigeng Zhou; Yize Xiao; Biao Huang; Xiaojun Xu; Lifeng Lin; Tao Liu; Jianpeng Xiao; et al. (Stochastic Environmental Research and Risk Assessment, 2021)

Mesenchymal Stromal Cell-Derived Extracellular Vesicles in the Treatment of Diabetic Foot Ulcers: Application and Challenges - Tao An; Yi Chen; Yingchun Tu; Ping Lin (Stem Cell Reviews and Reports, 2021)

Phylogeny and taxonomy of two new Alternaria (Ascomycota: Pleosporaceae) species in section Gypsophilae from China - Lin He; Hong Cheng; Aye Aye Htun; Hui Ge; Zhen Zhou Xia; Jian Wei Guo; Jian Xin Deng; Tao Du (Mycological Progress, 2021)

Increased depression risk for elderly women with high blood levels of strontium and barium - Jia Lv; Yan-ling Li; Wen-qiang Ren; Rong Li; Jian-rong Chen; Chao Bao; Zhi-ping Du; Shun Feng; Ling Gu; Hui Gao; Kai-yong Liu; Lin-sheng Yang; et al. (Environmental Chemistry Letters, 2021)

Relative contributions of global warming, AMO and IPO to the land precipitation variabilities since 1930s - Li Tao; X. San Liang; Lin Cai; Jiuwei Zhao; Meng Zhang (Climate Dynamics, 2021)

Experimental and numerical study on the fragmentation mechanism of a single calcareous sand particle under normal compression - Du-min Kuang; Zhi-lin Long; Rui-qi Guo; Tao Zhao; Kai Wu (Bulletin of Engineering Geology and the Environment, 2021)

Clinical phenotypes combined with saturation genome editing identifying the pathogenicity of BRCA1 variants of uncertain significance in breast cancer - Qiting Wan; Li Hu; Tao Ouyang; Jinfeng Li; Tianfeng Wang; Zhaoqing Fan; Tie Fan; Benyao Lin; Ye Xu; Yuntao Xie (Familial Cancer, 2021)

Correction to: Effect of Surface Property on the Release and Oral Absorption of Solid Sirolimus-Containing Self-Microemulsifying Drug Delivery System - Xueting Zhang; Zhenzhen Chen; Chun Tao; Jing Zhang; Minxin Zhang; Jialiang Zhang; Zhihong Liu; Jiao Lin; Hang Xu; Qian Zhang; Hongtao Song (AAPS PharmSciTech, 2021)

Effect of Surface Property on the Release and Oral Absorption of Solid Sirolimus-Containing Self-microemulsifying Drug Delivery System - Xueting Zhang; Zhenzhen Chen; Chun Tao; Jing Zhang; Minxin Zhang; Jialiang Zhang; Zhihong Liu; Jiao Lin; Hang Xu; Qian Zhang; Hongtao Song (AAPS PharmSciTech, 2021)

Remediation of contaminated soil and groundwater using chemical reduction and solidification/stabilization method: a case study - Shi-Feng Lu; Yu-Lin Wu; Zhan Chen; Tao Li; Chao Shen; Lin-Kang Xuan; Ling Xu (Environmental Science and Pollution Research, 2021)

Model test on support scheme for carbonaceous slate tunnel in high geostress zone at high depth - Zhi-gang Tao; Shu-lin Ren; Gan Li; Hao-tian Xu; Sen-lin Luo; Man-chao He (Journal of Mountain Science, 2021)

Projections from Infralimbic Cortex to Paraventricular Thalamus Mediate Fear Extinction Retrieval - Yan Tao; Cheng-Yun Cai; Jia-Yun Xian; Xiao-Lin Kou; Yu-Hui Lin; Cheng Qin; Hai-Yin Wu; Lei Chang; Chun-Xia Luo; Dong-Ya Zhu (Neuroscience Bulletin, 2021)

Genome-Wide Association Study Identifies Genomic Loci of Sex Determination and Gonadosomatic Index Traits in Large Yellow Croaker (Larimichthys crocea) - Huanling Lin; Zhixiong Zhou; Ji Zhao; Tao Zhou; Huaqiang Bai; Qiaozhen Ke; Fei Pu; Weiqiang Zheng; Peng Xu (Marine Biotechnology, 2021)

H2S probe CPC inhibits autophagy and promotes apoptosis by inhibiting glutathionylation of Keap1 at Cys434 - Na Li; JuYuan Wang; XiaoLing Zang; ZhaoYang Wang; Tao Zhang; BaoXiang Zhao; JunYing Miao; ZhaoMin Lin (Apoptosis, 2021)

Simulated Relationship between Wintertime ENSO and East Asian Summer Rainfall: From CMIP3 to CMIP6 - Yuanhai Fu; Zhongda Lin; Tao Wang (Advances in Atmospheric Sciences, 2021)

Community structure of bacterioplankton and its relationship with environmental factors in the upper reaches of the Heihe River in Qinghai Plateau - Zhang Qian‐Qian; Jian Sheng‐Long; Li Ke‐Mao; Wu Zhen‐Bing; Guan Hong‐Tao; Hao Jin‐Wen; Wang Shu‐Yi; Lin Yao‐Yao; Wang Guo‐Jie; Li Ai‐Hua (Environmental Microbiology, 2021)
Summary Planktonic microorganisms play a key role in the biogeochemical processes of the aquatic system, and they may be affected by many factors. High‐throughput sequencing technology was used in this study to investigate and study the bacterioplankton community of water bodies in the upper reaches of the Heihe River Basin in Qinghai Plateau. Results showed that Proteobacteria, Firmicutes, Bacteroidetes and Actinobacteria are the predominant phyla in this river section, while the main genera are Thiomonas , Acidibacillus , Acidocella , Rhodanobacter , Acidithiobacter and Gallionella , which are autochthonous in the acid‐mine drainage. Additionally, total nitrogen, total phosphorus, permanganate index and pH are significantly correlated with the bacterioplankton abundance and are the main limiting factors for the spatial distribution of the bacterioplankton. PICRUSt inferred that the mainstream microbial assemblages had a higher abundance of KOs belong to metabolism of terpenoids and polyketides, while the tributary had higher abundance of KOs belong to the immune system. The relationship between bacterioplankton community composition and environmental factors in the Heihe River basin was discussed for the first time in this study, which provides a theoretical basis for the healthy, orderly development of the water environment in the Heihe River Basin.

Mechanisms of high-frequency dinoflagellate blooms of Scrippsiella trochoidea in Daya Bay, South China Sea - Yuan Tian; Simin Hu; Xianzhi Lin; Hui Huang; Xingyu Song; Yan Yan; Xuedong Xie; Tao Li; Sheng Liu (Journal of Oceanology and Limnology, 2021)

Facile Microwave-Assisted Synthesis of Functionalized Carbon Nitride Quantum Dots as Fluorescence Probe for Fast and Highly Selective Detection of 2,4,6-Trinitrophenol - Shikong Lu; Meihua Xue; Aojia Tao; Yuhui Weng; Bixia Yao; Wen Weng; Xiuchun Lin (Journal of Fluorescence, 2021)

Discrimination of Tourette Syndrome Based on the Spatial Patterns of the Resting–State EEG Network - Keyi Duan; Qian Wu; Yuanyuan Liao; Yajing Si; Joyce Chelangat Bore; Fali Li; Qin Tao; Li Lin; Wei Lei; Xudong Hu; Dezhong Yao; Changfu Pei; et al. (Brain Topography, 2021)

Selenium Deficiency-Induced Damage and Altered Expression of Mitochondrial Biogenesis Markers in the Kidneys of Mice - Hehuan Lai; Tingting Nie; Yitong Zhang; Ying Chen; Jiaqi Tao; Tingting Lin; Tangdong Ge; Fenglan Li; Hui Li (Biological Trace Element Research, 2021)

Artificial Neural Network-based prediction of glacial debris flows in the ParlungZangbo Basin, southeastern Tibetan Plateau, China - Wang Tang; Hai-tao Ding; Ning-sheng Chen; Shang-Chang Ma; Li-hong Liu; Kang-lin Wu; Shu-feng Tian (Journal of Mountain Science, 2021)

Phylogenetic analysis of infectious bronchitis virus circulating in southern China in 2016–2017 and evaluation of an attenuated strain as a vaccine candidate - Libin Chen; Bin Xiang; Yanfen Hong; Qian Li; Haoyun Du; Qiuyan Lin; Ming Liao; Tao Ren; Chenggang Xu (Archives of Virology, 2021)

Influences of Physical Vegetation Management on Odonata Abundance in Urbanized Ecosystem: a Case Study in Northern Taiwan - Pin-Yuan Chen; Cheng-Tao Lin; Rita S. W. Yam; Hsiao-Wei Yuan (Wetlands, 2020)

Long non-coding RNA LINC00460 promotes proliferation and inhibits apoptosis of cervical cancer cells by targeting microRNA-503-5p - Lin Lin; Bing Xin; Tao Jiang; Xin-lu Wang; Hua Yang; Tie-mei Shi (Molecular and Cellular Biochemistry, 2020)

Association of in-hospital intensive statins dosage and death in arteriosclerotic cardiovascular disease with percutaneous coronary intervention: insights of multicentre cohort from China - Peng-yuan Chen; Yuan-hui Liu; Chong-yang Duan; Hua-lin Fan; Li-huan Zeng; Wei Guo; Lei Jiang; Xue-biao Wei; Wen-fei He; Sha Tao; Zhi-qiang Guo; Ji-yan Chen; et al. (European Journal of Clinical Pharmacology, 2020)

Urbanization and carbon emission: causality evidence from the new industrialized economies - Khalid Khan; Chi-Wei Su; Ran Tao; Lin-Na Hao (Environment, Development and Sustainability, 2020)

Stability analysis of open-pit gold mine slopes and optimization of mining scheme in Inner Mongolia, China - Shu-lin Ren; Zhi-gang Tao; Man-chao He; Shi-hui Pang; Meng-nan Li; Hao-tian Xu (Journal of Mountain Science, 2020)

Prevalence and Bayesian Phylogenetics of Enteroviruses Derived From Environmental Surveillance Around Polio Vaccine Switch Period in Shandong Province, China - Chenxu Zhao; Xiaojuan Lin; Feng Ji; Ping Xiong; Yao Liu; Suting Wang; Peng Chen; Qing Xu; Li Zhang; Zexin Tao; Aiqiang Xu (Food and Environmental Virology, 2020)

Two new sesquiterpenoid glycosides from the stems of Zanthoxylum armatum DC - Ya-Lin Liu; Liang-Liang Gao; Tong-Tong Song; Tao Guo; Jun Chang (Natural Product Research, 2020)

One-pot synthesis of substituted pyrrole–imidazole derivatives with anticancer activity - Ming Zhang; Yong Ding; Hong-Xia Qin; Zhi-Gang Xu; Hai-Tao Lan; Dong-Lin Yang; Cheng Yi (Molecular Diversity, 2020)

Quantitative Assessment of Hippocampal Tau Pathology in AD and PART - Lei Zhang; Yankai Jiang; Jie Zhu; Huazheng Liang; Xiangyang He; Jiahong Qian; Hai Lin; Yubo Tao; Keqing Zhu (Journal of Molecular Neuroscience, 2020)
To quantitatively assess the distribution pattern of hippocampal tau pathology in Alzheimer’s disease (AD) and primary age-related tauopathy (PART), we investigated the distribution of phosphorylated tau protein (AT8) in 6 anatomically defined subregions of the hippocampal formation and developed a mathematical algorithm to compare the patterns of tau deposition in PART and AD. We demonstrated regional patterns of selective vulnerability as distinguishing features of PART and AD in functionally relevant structures of the hippocampus. In AD cases, tau pathology was high in both CA1 and subiculum, followed by CA2/3, entorhinal cortex (EC), CA4, and dentate gyrus (DG). In PART, the severity of tau pathology in CA1 and subiculum was high, followed by EC, CA2/3, CA4, and DG. There are significant differences between sector DG and CA1, DG and subiculum in both AD and PART.

Numerical analysis of loess and weak intercalated layer failure behavior under direct shearing and cyclic loading - Ze-lin Zhang; Tao Wang (Journal of Mountain Science, 2020)

Identification and characterization of Diaporthe eres causing leaf blight disease on the medicinal herb Polygonatum sibiricum - Hang Tao; Hao Wang; Shen-Xin Huang; Ye Zhang; Zi-Hui Zhang; Wang Liu; Ning-Xue Shi; Feng Zhu; Zhao-Lin Ji; Xiao-Ren Chen (Journal of General Plant Pathology, 2020)

Complete genome sequence of a novel recombinant avian leukosis virus isolated from a three-yellow chicken - Tao Sun; Ximei Wang; Wei Han; Xiaoling Ma; Weili Yin; Baohai Fang; Xiao Lin; Yang Li (Archives of Virology, 2020)

New sorbicillinoid derivatives with GLP-1R and eEF2K affinities from a sponge-derived fungus Penicillium chrysogenum 581F1 - Min-Jia Cao; Tao Zhu; Jing-Tang Liu; Liang Ouyang; Fan Yang; Hou-Wen Lin (Natural Product Research, 2020)

Effect of recombinant human granulocyte colony-stimulating factor on lymphocyte subsets in patients with COVID-19 - Guang-Bin Chen; Jian-Tao Lin; Zheng Zhang; Lei Liu (Infectious Diseases, 2020)

Genome-Wide Association Study of Body Shape-Related Traits in Large Yellow Croaker (Larimichthys crocea) - Shengnan Kong; Zhixiong Zhou; Tao Zhou; Ji Zhao; Lin Chen; Huanling Lin; Fei Pu; Qiaozhen Ke; Huaqiang Bai; Peng Xu (Marine Biotechnology, 2020)

Typical gene expression profile of pseudorabies virus reactivation from latency in swine trigeminal ganglion - Hai-Hua Wang; Jie Liu; Lin-Tao Li; Huan-Chun Chen; Wan-Po Zhang; Zheng-Fei Liu (Journal of NeuroVirology, 2020)

Assessing major factors impacts on the hydrogeochemistry in a riverside alluvial aquifer, northeast China - Li Wang; Tao Du; Qing Hu; Sijie Lin; Mingzhu Liu; Honghan Chen (Arabian Journal of Geosciences, 2020)

A study on the application of the distributed optical fiber sensing monitoring technology in the process of dismantling temporary tunnel shoring - Zi-Xiang Li; Gong-Yu Hou; Tao Hu; Tian-Ci Zhou; Hai-Lin Xiao (Arabian Journal of Geosciences, 2020)

Genesis of the Maoping carbonate-hosted Pb–Zn deposit, northeastern Yunnan Province, China: evidences from geology and C–O–S–Pb isotopes - Yufan He; Tao Wu; Zhilong Huang; Lin Ye; Ping Deng; Zhenzhong Xiang (Acta Geochimica, 2020)

Menaquinone-7 production in engineered Escherichia coli - Quanxiu Gao; Hao Chen; Wenzhao Wang; Jianzhong Huang; Yong Tao; Baixue Lin (World Journal of Microbiology and Biotechnology, 2020)

A novel peroxiredoxin from the antagonistic endophytic bacterium Enterobacter sp. V1 contributes to cotton resistance against Verticillium dahliae - Lin Zhang; Ye Tao; Suya Zhao; Xiaoyan Yin; Junmei Chen; Miao Wang; Yingfan Cai; Qiuhong Niu (Plant and Soil, 2020)

The dominant model analysis of Sirt3 genetic variants is associated with susceptibility to tuberculosis in a Chinese Han population - Tao Wu; Lin Jiao; Hao Bai; Xuejiao Hu; Minjin Wang; Zhenzhen Zhao; Hui Xue; Binwu Ying (Molecular Genetics and Genomics, 2020)

Cu(OH)2 nanorods undergo sulfidation in water: in situ formation of CuO nanorods as intermediates and enhanced toxicity to Escherichia coli - Heming Su; Xiaoting Qian; Zhouhang Gu; Zhenlan Xu; Haijin Lou; Xinyun Bian; Tao Zeng; Daohui Lin; Juliane Filser; Lingxiangyu Li (Environmental Chemistry Letters, 2020)

Immune effect of a Newcastle disease virus DNA vaccine with IL-12 as a molecular adjuvant delivered by electroporation - Peng Xie; Yanling Li; Yaling Li; Jianpeng Liang; Bin Xiang; Qiuyan Lin; Jiaqi Jin; Chan Ding; Chenggang Xu; Tao Ren (Archives of Virology, 2020)

Electrolytic enrichment method for tritium determination in the Arctic Ocean using liquid scintillation counter - Feng Lin; Tao Yu; Wen Yu; Jialin Ni; Li Lin (Acta Oceanologica Sinica, 2020)

Identification and validation of stable quantitative trait loci for grain filling rate in common wheat (Triticum aestivum L.) - Yu Lin; Xiaojun Jiang; Yang Tao; Xilan Yang; Zhiqiang Wang; Fangkun Wu; Shihang Liu; Caixia Li; Mei Deng; Jian Ma; Guangdeng Chen; Yuming Wei; et al. (Theoretical and Applied Genetics, 2020)

RETRACTED ARTICLE: Paeoniflorin attenuates early brain injury through reducing oxidative stress and neuronal apoptosis after subarachnoid hemorrhage in rats - Tao Wang; Ling Xu; Lei Gao; Lin Zhao; Xin-hong Liu; Yan-yan Chang; Yun-lin Liu (Metabolic Brain Disease, 2020)

Size Effect on Mechanical Properties of Rock-Like Materials with Three Joints - Tao Dong; Ping Cao; Qibin Lin; Fei Wang; Zhizhen Liu; Ji Hao; Yezhen Xie (Geotechnical and Geological Engineering, 2020)

Lignin – An underutilized, renewable and valuable material for food industry - Jianming Tao; Sheng Li; Fayin Ye; Yun Zhou; Lin Lei; Guohua Zhao (Critical Reviews in Food Science and Nutrition, 2020)

MiR-615 Regulates NSC Differentiation In Vitro and Contributes to Spinal Cord Injury Repair by Targeting LINGO-1 - Hongfu Wu; Lu Ding; Yuhui Wang; Tang-Bin Zou; Tao Wang; Wenjin Fu; Yong Lin; Xiaomin Zhang; Kangzhen Chen; Yutian Lei; Caitang Zhong; Chuanming Luo (Molecular Neurobiology, 2020)

Long interpregnancy interval and adverse perinatal outcomes: A retrospective cohort study - Jing Lin; Han Liu; Dan-Dan Wu; Hong-Tao Hu; Hui-Hui Wang; Cheng-Liang Zhou; Xin-Mei Liu; Xiao-Jun Chen; Jian-Zhong Sheng; He-Feng Huang (Science China Life Sciences, 2020)

Leaf-mimicking katydids from the Middle Miocene of Yunnan, southwestern China (Orthoptera: Tettigoniidae) - André Nel; Bo Wang; Michael S. Engel; Jian Huang; Lin-Bo Jia; Tao Su; Torsten Wappler (PalZ, 2020)

3D-QSAR, HQSAR, molecular docking, and new compound design study of 1,3,6-trisubstituted 1,4-diazepan-7-ones as human KLK7 inhibitors - Le Fu; Yi Chen; Chun-mei Xu; Tao Wu; Hong-mei Guo; Zhi-hua Lin; Rui Wang; Mao Shu (Medicinal Chemistry Research, 2020)

Nr1d1 affects autophagy in the skeletal muscles of juvenile Nile tilapia by regulating the rhythmic expression of autophagy-related genes - Ping Wu; Jia Cheng; Lin Chen; Jing Xiang; Yaxiong Pan; Yongzhan Zhang; Tao Zheng; Naiyuan Liu; Wuying Chu; Jianshe Zhang (Fish Physiology and Biochemistry, 2020)

Effect of proton pump inhibitors on voriconazole concentrations in Chinese patients with malignant hematological diseases - Qi Huang; Qiong Liu; Tao Yin; Lin Hu; Hanjun Ding; Shao Liu; Yueping Jiang (European Journal of Clinical Pharmacology, 2020)

Detection of serum IgM and IgG for COVID-19 diagnosis - Ling Zhong; Junlan Chuan; Bo Gong; Ping Shuai; Yu Zhou; Yi Zhang; Zhilin Jiang; Dingding Zhang; Xiaoqi Liu; Shi Ma; Yi Huang; He Lin; et al. (Science China Life Sciences, 2020)

Resequencing 93 accessions of coffee unveils independent and parallel selection during Coffea species divergence - Lifang Huang; Xiaoyang Wang; Yunping Dong; Yuzhou Long; Chaoyun Hao; Lin Yan; Tao Shi (Plant Molecular Biology, 2020)

Duplex real-time quantitative PCR for simultaneous detection and quantification of Pratylenchus neglectus and P. thornei - Borong Lin; Ye Tao; Honghong Wang; Jinling Liao; Kan Zhuo (European Journal of Plant Pathology, 2020)

Formation mechanism of a rainfall triggered complex landslide in southwest China - Qiu-xiang Huang; Xiang-tao Xu; P. H. S. W. Kulatilake; Feng Lin (Journal of Mountain Science, 2020)

Effects of small nucleolar RNA SNORD44 on the proliferation, apoptosis and invasion of glioma cells - Xian-Ru Xia; Wen-Cui Li; Zong-Tao Yu; Jie Li; Chun-Yan Peng; Li Jin; Guo-Lin Yuan (Histochemistry and Cell Biology, 2020)

Impacts of elevated temperature and pCO2 on the brooded larvae of Pocillopora damicornis from Luhuitou Reef, China: evidence for local acclimatization - Lei Jiang; Ming-Lan Guo; Fang Zhang; Yu-Yang Zhang; Guo-Wei Zhou; Xin-Ming Lei; Xiang-Cheng Yuan; You-Fang Sun; Tao Yuan; Lin Cai; Jian-Sheng Lian; Sheng Liu; et al. (Coral Reefs, 2020)

Asymmetric crustal structure of the ultraslow-spreading Mohns Ridge - Tao Zhang; Jian Lin; Jinyao Gao (International Geology Review, 2020)

Electroacupuncture ameliorates learning and memory deficits via hippocampal 5-HT1A receptors and the PKA signaling pathway in rats with ischemic stroke - Zhifu Wang; Bingbing Lin; Weilin Liu; Hongwei Peng; Changming Song; Jia Huang; Zuanfang Li; Lidian Chen; Jing Tao (Metabolic Brain Disease, 2020)

Potential Genes Related to Levofloxacin Resistance in Mycobacterium tuberculosis Based on Transcriptome and Methylome Overlap Analysis - Hai-cheng Li; Hui-xin Guo; Tao Chen; Wei Wang; Zhu-hua Wu; Liang Chen; Hui-zhong Wu; Gao-po Xu; Xun-xun Chen; Lin Zhou (Journal of Molecular Evolution, 2020)
Drug-resistant Mycobacterium tuberculosis ( M. tuberculosis ) has become an increasingly serious public health problem and has complicated tuberculosis (TB) treatment. Levofloxacin (LOF) is an ideal anti-tuberculosis drug in clinical applications. However, the detailed molecular mechanisms of LOF-resistant M. tuberculosis in TB treatment have not been revealed. Our study performed transcriptome and methylome sequencing to investigate the potential biological characteristics of LOF resistance in M. tuberculosis H37Rv. In the transcriptome analysis, 953 differentially expressed genes (DEGs) were identified; 514 and 439 DEGs were significantly downregulated and upregulated in the LOF-resistant group and control group, respectively. The KEGG pathway analysis revealed that 97 pathways were enriched in this study. In the methylome analysis, 239 differentially methylated genes (DMGs) were identified; 150 and 89 DMGs were hypomethylated and hypermethylated in the LOF-resistant group and control group, respectively. The KEGG pathway analysis revealed that 74 pathways were enriched in this study. The overlap study suggested that 25 genes were obtained. It was notable that nine genes expressed downregulated mRNA and upregulated methylated levels, including pgi , fadE4 , php , cyp132 , pckA , rpmB1 , pfkB , acg , and ctpF , especially cyp132 , pckA , and pfkB , which were vital in LOF-resistant M. tuberculosis H37Rv. The overlapping genes between transcriptome and methylome could be essential for studying the molecular mechanisms of LOF-resistant M. tuberculosis H37Rv. These results may provide informative evidence for TB treatment with LOF.

Southward subduction of the Bangong-Nujiang Tethys Ocean: insights from ca. 161–129 Ma arc volcanic rocks in the north of Lhasa terrane, Tibet - Yue Tang; Qing-Guo Zhai; Pei-Yuan Hu; Sun-Lin Chung; Xu-Chang Xiao; Hai-Tao Wang; Zhi-Cai Zhu; Wei Wang; Hao Wu; Hao-Yang Lee (International Journal of Earth Sciences, 2020)

The NADPH oxidase in Volvariella volvacea and its differential expression in response to mycelial ageing and mechanical injury - Jun-Jie Yan; Zong-Jun Tong; Yuan-Yuan Liu; Zi-Yan Lin; Ying Long; Xing Han; Wei-Nan Xu; Qian-Hui Huang; Yong-Xin Tao; Bao-Gui Xie (Brazilian Journal of Microbiology, 2020)

Distribution and features of landslides in the Tianshui Basin, Northwest China - Ze-lin Zhang; Tao Wang; Shu-ren Wu (Journal of Mountain Science, 2020)

A deep learning approach to conflating heterogeneous geospatial data for corn yield estimation: A case study of the US Corn Belt at the county level - Hao Jiang; Hao Hu; Renhai Zhong; Jinfan Xu; Jialu Xu; Jingfeng Huang; Shaowen Wang; Yibin Ying; Tao Lin (Global Change Biology, 2020)
Understanding large‐scale crop growth and its responses to climate change are critical for yield estimation and prediction, especially under the increased frequency of extreme climate and weather events. County‐level corn phenology varies spatially and interannually across the Corn Belt in the United States, where precipitation and heat stress presents a temporal pattern among growth phases (GPs) and vary interannually. In this study, we developed a long short‐term memory (LSTM) model that integrates heterogeneous crop phenology, meteorology, and remote sensing data to estimate county‐level corn yields. By conflating heterogeneous phenology‐based remote sensing and meteorological indices, the LSTM model accounted for 76% of yield variations across the Corn Belt, improved from 39% of yield variations explained by phenology‐based meteorological indices alone. The LSTM model outperformed least absolute shrinkage and selection operator (LASSO) regression and random forest (RF) approaches for end‐of‐the‐season yield estimation, as a result of its recurrent neural network structure that can incorporate cumulative and nonlinear relationships between corn yield and environmental factors. The results showed that the period from silking to dough was most critical for crop yield estimation. The LSTM model presented a robust yield estimation under extreme weather events in 2012, which reduced the root‐mean‐square error to 1.47 Mg/ha from 1.93 Mg/ha for LASSO and 2.43 Mg/ha for RF. The LSTM model has the capability to learn general patterns from high‐dimensional (spectral, spatial, and temporal) input features to achieve a robust county‐level crop yield estimation. This deep learning approach holds great promise for better understanding the global condition of crop growth based on publicly available remote sensing and meteorological data.

NOD1 inhibits proliferation and enhances response to chemotherapy via suppressing SRC-MAPK pathway in hepatocellular carcinoma - Xiaomin Ma; Yumin Qiu; Lihui Zhu; Yunxue Zhao; Yueke Lin; Dapeng Ma; Zhenzhi Qin; Caiyu Sun; Xuecheng Shen; Tao Li; Lihui Han (Journal of Molecular Medicine, 2020)

Non-motor Symptoms in Parkinson’s Disease Patients with Parkin Mutations: More Depression and Less Executive Dysfunction - Jie Song; Bo Shen; Yu-Jie Yang; Feng-tao Liu; Jue Zhao; Yi-Lin Tang; Chen Chen; Zheng-Tong Ding; Yu An; Jian-Jun Wu; Yi-Min Sun; Jian Wang (Journal of Molecular Neuroscience, 2020)

Classification of Tectonic and Nontectonic Earthquakes by an Integrated Learning Algorithm - Tao Ren; Pengyu Wang; Mengnan Lin; Xiaoyu Liu; Hongfeng Chen; Jie Liu (Pure and Applied Geophysics, 2020)

The Arabidopsis kinase-associated protein phosphatase KAPP, interacting with protein kinases SnRK2.2/2.3/2.6, negatively regulates abscisic acid signaling - Kai Lu; Ya-Dong Zhang; Chun-Fang Zhao; Li-Hui Zhou; Qing-Yong Zhao; Tao Chen; Cai-Lin Wang (Plant Molecular Biology, 2020)

C, N, and P stoichiometry and their interaction with different plant communities and soils in subtropical riparian wetlands - Meng-Fei Yu; Yongxia Tao; Wenzhi Liu; Wei Xing; Guihua Liu; Lai Wang; Lin Ma (Environmental Science and Pollution Research, 2020)

Expression of the small cysteine-rich protein SCR96 from Phytophthora cactorum in mammalian cells: phytotoxicity and exploitation of its polyclonal antibody - Shen-Xin Huang; Zi-Hui Zhang; Wang Liu; Hang Tao; Ye Zhang; Ning-Xue Shi; Feng Zhu; Zhao-Lin Ji; Xiao-Ren Chen (Biotechnology Letters, 2020)

Metabolomic profiling on rat brain of prenatal malnutrition: implicated for oxidative stress and schizophrenia - Fei Xu; Xin Li; Weibo Niu; Gaini Ma; Qianqian Sun; Yan Bi; Zhenming Guo; Decheng Ren; Jiaxin Hu; Fan Yuan; Ruixue Yuan; Lei Shi; et al. (Metabolic Brain Disease, 2019)

Phosphorus losses under heavy rain from the sloping farmlands in the purple hilly region of Southwestern China - Xiaoling He; Yongdong Wang; Tingxuan Li; Shuqin He; Zicheng Zheng; Xizhou Zhang; Huagang Huang; Haiying Yu; Tao Liu; Chaowen Lin (Journal of Soils and Sediments, 2019)

Correction to: Human skin-derived ABCB5+ stem cell injection improves liver disease parameters in Mdr2KO mice - Vanessa Hartwig; Bedair Dewidar; Tao Lin; Anne Dropmann; Christoph Ganss; Mark Andreas Kluth; Nils Tappenbeck; Lysann Tietze; Bruno Christ; Markus Hermann Frank; Roger Vogelmann; Matthias Philip Alexander Ebert; et al. (Archives of Toxicology, 2019)

A simple and sensitive SYBR Gold-based assay to quantify DNA–protein interactions - Spencer Schreier; Bhanu Prakash Petla; Tao Lin; Suvobrata Chakravarty; Senthil Subramanian (Plant Molecular Biology, 2019)

Integrated analysis of hypoxia-induced miR-210 signature as a potential prognostic biomarker of hepatocellular carcinoma: a study based on The Cancer Genome Atlas - Yi Dai; Ji-liang Shen; Xue-yong Zheng; Tian-yu Lin; Hai-tao Yu (Journal of Zhejiang University-SCIENCE B, 2019)

Effect of Different Glucose Concentrations on Small RNA Levels and Adherence of Streptococcus mutans - Shanshan Liu; Yan Zhou; Ye Tao; Peilin Zhuang; Liangyue Pang; Qinghui Zhi; Huancai Lin (Current Microbiology, 2019)

A new indole-type alkaloid from the roots of Clematis florida var. plena - Kai-Hui Sun; Xin-Hua Ma; Xian-Ming Zeng; Zhong-Yue Lin; Yu-Mei Cai; Hai-Tao Zhang; Xiao-Yan Lin; Shi-Biao Feng; Tian-Hua Zhong; Yong-Hong Zhang (Natural Product Research, 2019)

Two-factor ANOVA of SSH and RNA-seq analysis reveal development-associated Pi-starvation genes in oilseed rape - Zhong-Wei Zhang; Ling-Yang Feng; Jian-Hui Wang; Yu-Fan Fu; Xin Cai; Chang-Quan Wang; Jun-Bo Du; Ming Yuan; Yang-Er Chen; Pei-Zhou Xu; Ting Lan; Guang-Deng Chen; et al. (Planta, 2019)

Genetic dissection of stalk lodging-related traits using an IBM Syn10 DH population in maize across three environments (Zea mays L.) - Yanling Zhang; Tianhu Liang; Min Chen; Yinchao Zhang; Tao Wang; Haijian Lin; Tingzhao Rong; Chaoying Zou; Peng Liu; Michael Lee; Guangtang Pan; Yaou Shen; et al. (Molecular Genetics and Genomics, 2019)

Reducing ammonia and greenhouse gas emission with adding high levels of superphosphate fertilizer during composting - Juan Wu; Shengzhou He; Guoxue Li; Zehua Zhao; Yuquan Wei; Zhong Lin; De Tao (Environmental Science and Pollution Research, 2019)

Selective feeding of bay scallop Argopecten irradians on phytoplankton community revealed by HPLC analysis of phytopigments in Bohai Sea, China - Tao Jiang; Longhua Wang; Fuchong Zhang; Xiao Fang; Lin Lu; Jihong Zhang; Wei Wang; Keming Qu; Chao Chai (Journal of Oceanology and Limnology, 2019)

Exosomes from patients with Parkinson’s disease are pathological in mice - Chao Han; Nian Xiong; Xingfang Guo; Jinsha Huang; Kai Ma; Ling Liu; Yun Xia; Yan Shen; Jie Li; Haiyang Jiang; Luxi Wang; Shiyi Guo; et al. (Journal of Molecular Medicine, 2019)

Different removal efficiency of disinfection-byproduct precursors between dichloroacetonitrile (DCAN) and dichloroacetamide (DCAcAm) by up-flow biological activated carbon (UBAC) process - Han Chen; Tao Lin; Wei Chen; Hang Xu; Hui Tao (Environmental Science and Pollution Research, 2019)

Assessment of slope construction risk uncertainty based on index importance ranking - Daming Lin; Ping Chen; Jilei Ma; Yun Zhao; Tao Xie; Renmao Yuan; Lin Li (Bulletin of Engineering Geology and the Environment, 2019)

Human skin-derived ABCB5+ stem cell injection improves liver disease parameters in Mdr2KO mice - Vanessa Hartwig; Bedair Dewidar; Tao Lin; Anne Dropmann; Christoph Ganss; Mark Andreas Kluth; Nils Tappenbeck; Lysann Tietze; Bruno Christ; Markus Frank; Roger Vogelmann; Matthias Philip Alexander Ebert; et al. (Archives of Toxicology, 2019)

Analysis of the elemental spectral characteristics of single elemental capture spectrum log using Monte-Carlo simulation - Chang-Lin Lan; Xu-Wen Zhan; Hong-Liang Wu; Yi Zhang; Tong Liu; Zhou Feng; Tao Lv (Applied Geophysics, 2019)

MOF Capacitates Cyclodextrin to Mega-Load Mode for High-Efficient Delivery of Valsartan - Wei Zhang; Tao Guo; Caifen Wang; Yuanzhi He; Xi Zhang; Guangyu Li; Yizhi Chen; Jun Li; Yangjing Lin; Xu Xu; Li Wu; Suxia Zhang; et al. (Pharmaceutical Research, 2019)

Age-Related Reduction in Cortical Thickness in First-Episode Treatment-Naïve Patients with Schizophrenia - Yin Lin; Mingli Li; Yi Zhou; Wei Deng; Xiaohong Ma; Qiang Wang; Wanjun Guo; Yinfei Li; Lijun Jiang; Xun Hu; Nanyin Zhang; Tao Li (Neuroscience Bulletin, 2019)

Development of polymorphic microsatellite markers for tree peony Paeonia delavayi (Paeoniaceae) using ddRAD-seq data - Shao-Lin Tan; Peter M. Hollingsworth; Han-Tao Qin; Lin-Jiang Ye; Jia-Yun Zou; Lian-Ming Gao (Molecular Biology Reports, 2019)

A structure–activity relationship study of phenyl sesquiterpenoids on efflux inhibition against Staphylococcus aureus - Zhong-Lin Sun; Tao Liu; Simon Gibbons; Qing Mu (Medicinal Chemistry Research, 2019)

Comparative Transcriptome Analysis Reveals Differentially Expressed Genes and Signaling Pathways Between Male and Female Red-Tail Catfish (Mystus wyckioides) - Jun-Jie Wu; Yu-Lin Zhou; Zhong-Wei Wang; Guang-Hua Li; Fang-Peng Jin; Li-Li Cui; Hai-Tao Gao; Xin-Ping Li; Li Zhou; Jian-Fang Gui (Marine Biotechnology, 2019)

Transport of colloidal phosphorus in runoff and sediment on sloping farmland in the purple soil area of south-western China - Xiaoling He; Zicheng Zheng; Tingxuan Li; Shuqin He; Xizhou Zhang; Yongdong Wang; Huagang Huang; Haiying Yu; Tao Liu; Chaowen Lin (Environmental Science and Pollution Research, 2019)