Shear behavior of bio-cemented calcareous sand treated through bio-stimulation under the direct shear condition - Yi-Jie Wang; Ning-Jun Jiang; Xiao-Le Han; Ogul Doygun; Yan-Jun Du (Bulletin of Engineering Geology and the Environment, 2022)

Reciprocal modulation between cigarette smoking and internet gaming disorder on participation coefficient within functional brain networks - Xianxin Qiu; Xu Han; Yao Wang; Weina Ding; Yawen Sun; Hao Lei; Yan Zhou; Fuchun Lin (Brain Imaging and Behavior, 2022)

Childhood trauma is associated with social anhedonia and brain gray matter volume differences in healthy subjects - Jie Fan; Wanting Liu; Jie Xia; Feng Gao; Chuyi Meng; Yan Han; Huan Zhou; Jinyao Yi; Changlian Tan; Xiongzhao Zhu (Brain Imaging and Behavior, 2022)

Machine learning-based methods for sea surface rainfall detection from CYGNSS delay-doppler maps - Jinwei Bu; Kegen Yu; Jun Ni; Qingyun Yan; Shuai Han; Jin Wang; Changyang Wang (GPS Solutions, 2022)

Temporal and spatial distribution characteristics and source analysis of dissolved organic nitrogen in the surface sediment of the Caohai Lake, southwest China - Xinting Yan; Jiahao Liao; Xingxing Cao; Zhiwei Han (Environmental Science and Pollution Research, 2022)

Correction to: MicroRNA-124 upregulation inhibits proliferation and invasion of osteosarcoma cells by targeting sphingosine kinase 1 - Yan Zhou; Yanzhen Han; Zhitao Zhang; Zhe Shi; Liyuan Zhou; Xiaohong Liu; Xiaoyan Jia (Human Cell, 2022)

Variations in terrestrial oxygen sources under climate change - Lei Ding; Jianping Huang; Changyu Li; Dongliang Han; Xiaoyue Liu; Haiyun Li; Yan Bai; Jiping Huang (Science China Earth Sciences, 2022)

Feasibility Studies of Nebulized SARS-CoV-2 Neutralizing Antibody in Mice and Cynomolgus Monkeys - Jilei Jia; Zhaojuan Yin; Xiao Zhang; Huimin Li; Dan Meng; Qianqian Liu; Hongfang Wang; Meng Han; Shixiang Suo; Yan Liu; Ping Hu; Chunyun Sun; et al. (Pharmaceutical Research, 2022)
Purpose Neutralizing antibodies, administrated through intravenous infusion, have shown to be highly efficacious in treating mild and moderate COVID-19 caused by SARS-CoV-2 infection in the lung. However, antibodies do not transport across the plasma-lung barrier efficiently, and up to 100 mg/kg dose was used in human causing significant supply and cost burdens. This study was to explore the feasibility of nebulized antibodies inhalation delivery as an alternative route. Methods HB27, a potent RBD-specific humanized monoclonal antibody (Zhu et al. in National Sci Rev. 8:nwaa297, 2020), showed excellent protection against SARS-CoV-2 in animal model and good safety profile in clinical studies. The pharmacokinetics and preliminary safety of HB27 administrated through the respiratory tract were studied in mice and cynomolgus monkeys here. Results At a single 5 mg/kg dose, the peak HB27 concentration in mice pulmonary epithelial lining fluid (ELF) reached 857.8 μg/mL, 670-fold higher than the PRNT 90 value of 1.28 μg/mL, and maintained above PRNT 90 over 240 h. In contrast, when administrated by intravenous injection at a 5 mg/kg dose, the antibody concentrations in mice ELF were below PRNT 90 value throughout, and were about 50-fold lower than that in the serum. In cynomolgus monkeys administrated with a single dose through inhalation, the antibody concentration in ELF remained high within 3 days. No drug-related safety concerns were observed in the studies. Conclusions The study demonstrated that nebulized neutralizing antibody delivery though inhalation could be a more efficient and efficacious alternative approach for treating COVID-19 and other respiratory infectious diseases, and warrants further evaluation in clinical studies.

Movement Disorder and Neurotoxicity Induced by Chronic Exposure to Microcystin-LR in Mice - Minghao Yan; Haibo Jin; Chun Pan; Hexing Hang; Dongmei Li; Xiaodong Han (Molecular Neurobiology, 2022)

A Highly Selective Fluorescent Probe for the Detection of Nitroreductase Based on a Naphthalimide Scaffold - Han Li; Feng Jintao; Zhen Wang; Yan Jia; Peng Li; Cuixia Yao; Zongjin Qu (Journal of Fluorescence, 2022)

Retraction Note: Bimatoprost Imprinted Silicone Contact Lens to Treat Glaucoma - Feng Yan; Yanxia Liu; Shulan Han; Qingsong Zhao; Nannan Liu (AAPS PharmSciTech, 2022)

Environment variables affect CPUE and spatial distribution of fishing grounds on the light falling gear fishery in the northwest Indian Ocean at different time scales - Haibin Han; Chao Yang; Heng Zhang; Zhou Fang; Bohui Jiang; Bing Su; Jianghua Sui; Yunzhi Yan; Delong Xiang (Frontiers in Marine Science, 2022)
To better develop and protect the pelagic fishery in the northwest Indian Ocean, China’s fishing enterprises have been producing pelagic fisheries in the said area for a long time. Based on the fishing log data of light falling gear in the northwest Indian Ocean from 2016 to 2020, this study analyzed the impact of different time scales on the catch rate and fishing ground center of gravity of light falling gear fishing grounds. We also explored the relationship between different time scales and catch per unit effort (CPUE) by using the fishing ground center of gravity, the Random Forest model (RF), and the generalized additive model (GAM). The results were shown as follows: (1) From 2016 to 2020, 76,576 t were captured, and 16,496 nets were operated; (2) The gravity center of fishing ground in the Northwest Indian Ocean moved to the northeast as a whole, and the monthly fishing ground gravity center changed first to the Southern and then to the northern; (3) RF model (R² = 0.709, RMSE = 0.2034, and prediction accuracy is 55.8%), which is better than the GAM model (R² = 0.632, RMSE = 0.2242, and prediction accuracy is 37.3%). In the RF model, the importance of time variables on CPUE was in the order of week, year, operation time, and lunar phase; in the GAM model, it was week, year, lunar phase, and operation time. On the whole, the importance of the long time scale (year, week) is greater than that of the short time scale (lunar phase and operation time). (4) The RF model and GAM model show that the most critical environmental variables were SST, DO, SSS, and Chla, and the least important were SSH, Δ50, and CV50. SST, Chla, and DO significantly impact pelagic fishing and CPUE and are critical reference indexes for predicting the Northwest Indian Ocean light falling gear fishing ground. (5) The 95% confidence interval showed that the suitable interval of time, space, and environmental variables in the RF model was much smaller than in the GAM model.

Stachybotranes A–D, phenylspirodrimanes from the wetland fungus Stachybotrys chartarum with cytotoxic activities - Yan-Ru Bao; Han-Lin Feng; Xin-Sheng Yao (Natural Product Research, 2022)

Comparative study on inhibitory effects of ferulic acid and p-coumaric acid on Salmonella Enteritidis biofilm formation - Jing-Guo Xu; Hui-Xue Hu; Jing-Yu Chen; Yan-Song Xue; Bekhzod Kodirkhonov; Bei-Zhong Han (World Journal of Microbiology and Biotechnology, 2022)

Cellular Heterogeneity and Plasticity of Skin Epithelial Cells in Wound Healing and Tumorigenesis - Jingru Wang; Jia He; Meishu Zhu; Yan Han; Ronghua Yang; Hongwei Liu; Xuejuan Xu; Xiaodong Chen (Stem Cell Reviews and Reports, 2022)
Cellular differentiation, the fundamental hallmark of cells, plays a critical role in homeostasis. And stem cells not only regulate the process where embryonic stem cells develop into a complete organism, but also replace ageing or damaged cells by proliferation, differentiation and migration. In characterizing distinct subpopulations of skin epithelial cells, stem cells show large heterogeneity and plasticity for homeostasis, wound healing and tumorigenesis. Epithelial stem cells and committed progenitors replenish each other or by themselves owing to the remarkable plasticity and heterogeneity of epidermal cells under certain circumstance. The development of new assay methods, including single-cell RNA sequence, lineage tracing assay, intravital microscopy systems and photon-ablation assay, highlight the plasticity of epidermal stem cells in response to injure and tumorigenesis. However, the critical mechanisms and key factors that regulate cellular plasticity still need for further exploration. In this review, we discuss the recent insights about the heterogeneity and plasticity of epithelial stem cells in homeostasis, wound healing and skin tumorigenesis. Understanding how stem cells collaborate together to repair injury and initiate tumor will offer new solutions for relevant diseases. Graphical Abstract Schematic abstract of cellular heterogeneity and plasticity of skin epithelial cells in wound healing and tumorigenesis

Silicon isotope fractionation dynamics during uptake and translocation by various crop species under three soil types - Jingjie Zhou; Sheng Tang; Wankun Pan; Han Xiao; Qingxu Ma; Yan Sun; Meng Xu; Mengjiao Liu; Lianghuan Wu (Plant and Soil, 2022)

Genetic architecture of embryogenic callus induction in maize from the perspective of population genomics - Liqiang Dai; Siping Han; Yan Zhang; Dongyun Hao (Plant Cell, Tissue and Organ Culture (PCTOC), 2022)

Prediction of Water Inflow into Tunnel Crossing Intersecting Faults Based on IDB Seepage Model - Jing Wu; Li Wu; Ya-ni Lu; Yan-hua Han; Jun-jie Jiang (Geotechnical and Geological Engineering, 2022)

Microfluidic preparation of a novel phoxim nanoemulsion pesticide against Spodoptera litura - Zong-Nan Li; Yu-Xuan Zhang; Zhi-Ang Zhang; Lian-Han Pan; Ping Li; Yan Xu; Sheng Sheng; Fu-An Wu; Jun Wang (Environmental Science and Pollution Research, 2022)

The Influence Mechanism of Vegetation Type on the Characteristics of nirS-Type Denitrifying Microbial Communities in Qinghai Lake Wetlands - Ni Zhang; Kelong Chen; Yan’gong Du; Yang Yang; Jun’an Yan; Han Bao; Dizhao Zuo; Wen Qi; Boliang Cui (Current Microbiology, 2022)

Spontaneous neural activity in the right fusiform gyrus and putamen is associated with consummatory anhedonia in obsessive compulsive disorder - Hongyu Du; Jie Xia; Jie Fan; Feng Gao; Xiang Wang; Yan Han; Changlian Tan; Xiongzhao Zhu (Brain Imaging and Behavior, 2022)

Longitalea arenae gen. nov., sp. nov. and Longitalea luteola sp. nov., two new members of the family Chitinophagaceae isolated from desert soil - Shuai Li; Lei Dong; Jia-Rui Han; Guo-Yuan Shi; Chun-Yan Lu; Lu Xu; Wen-Hui Lian; Dalal Hussien M. Alkhalifah; Wael N. Hozzein; Wen-Jun Li (Archives of Microbiology, 2022)

Effect of Angiogenesis in Bone Tissue Engineering - Jianhao Huang; Qixiu Han; Meng Cai; Jie Zhu; Lan Li; Lingfeng Yu; Zhen Wang; Gentao Fan; Yan Zhu; Jingwei Lu; Guangxin Zhou (Annals of Biomedical Engineering, 2022)

Post-transcriptional control of bacterial nitrogen metabolism by regulatory noncoding RNAs - Yueyue Han; Chao Li; Yongliang Yan; Min Lin; Xiubin Ke; Yunhua Zhang; Yuhua Zhan (World Journal of Microbiology and Biotechnology, 2022)
Nitrogen metabolism is the most basic process of material and energy metabolism in living organisms, and processes involving the uptake and use of different nitrogen sources are usually tightly regulated at the transcriptional and post-transcriptional levels. Bacterial regulatory noncoding RNAs are novel post-transcriptional regulators that repress or activate the expression of target genes through complementarily pairing with target mRNAs; therefore, these noncoding RNAs play an important regulatory role in many physiological processes, such as bacterial substance metabolism and stress response. In recent years, a study found that noncoding RNAs play a vital role in the post-transcriptional regulation of nitrogen metabolism, which is currently a hot topic in the study of bacterial nitrogen metabolism regulation. In this review, we present an overview of recent advances that increase our understanding on the regulatory roles of bacterial noncoding RNAs and describe in detail how noncoding RNAs regulate biological nitrogen fixation and nitrogen metabolic engineering. Furthermore, our goal is to lay a theoretical foundation for better understanding the molecular mechanisms in bacteria that are involved in environmental adaptations and metabolically-engineered genetic modifications.

A review of seismo-electromagnetic research in China - Guoze Zhao; Xuemin Zhang; Juntao Cai; Yan Zhan; Qinzhong Ma; Ji Tang; Xuebin Du; Bing Han; Lifeng Wang; Xiaobin Chen; Qibin Xiao; Xiangyu Sun; et al. (Science China Earth Sciences, 2022)

Isolation and characterization of SGF3, a novel Microviridae phage infecting Shigella flexneri - Han Lu; Wenbin Xiong; Zong Li; Peihan Yan; Ruyin Liu; Xinchun Liu (Molecular Genetics and Genomics, 2022)

Cellulomonas triticagri sp. nov., isolated from the rhizosphere soil of wheat (Triticum aestivum L.) - Chuanyu Han; Yuting Zhang; Bing Yu; Qiqi Shan; Junwei Zhao; Haoran Shi; Yuanyuan Tian; Yan Zhang; Chunyu Zhu; Wensheng Xiang (Archives of Microbiology, 2022)

Roseicella aquatilis sp. nov., isolated from freshwater lake - Dan-Dan Zhang; Ya-Nan Zhao; Rui-Han He; Yu-Qi Yan; Zong-Jun Du (Archives of Microbiology, 2022)

Comparative Study on Added Resistance and Seakeeping Performance of X-Bow and Wave-Piercing Monohull in Regular Head Waves - Shuling Chen; Beilei Zou; Changzhi Han; Shiqiang Yan (Journal of Marine Science and Engineering, 2022)
Bow shape has been recognized as an important factor influencing the seakeeping performance and added resistance of ships. This paper presents a numerical comparative study on added resistance and seakeeping of model ships with ‘X-bow’ and a wave-piercing monohull in regular head waves using a computational fluid dynamics (CFD) software. Different wave heights, wavelengths and forward speeds are considered in the systematic investigation in order to characterize the added resistance and wave-induced motions, and to explore the local wave patterns. The results show a considerably different hydrodynamic characteristic by different bow shapes.

High On-Treatment Platelet Reactivity as Predictor of Long-term Clinical Outcomes in Stroke Patients with Antiplatelet Agents - Huihui Lv; Zidong Yang; Haibo Wu; Mingyuan Liu; Xiaowei Mao; Xu Liu; Hongyan Ding; Zhuqing Shi; Yang Zhou; Qianyun Liu; Yongkang Zhang; Yinting Zhou; et al. (Translational Stroke Research, 2022)

Knowledge Difference of Tumor Nutrition Risk Among Thoracic Cancer Patients, Their Family Members, Physicians, and Nurses - Jiaojiao Suo; Yu Sun; Weigang Xiu; Yan Fu; Yijia Qin; Lili Zhong; Jialong Han; Huijie Zhou; Hao Wei; Yan Wang; Jiang Zhu (Journal of Cancer Education, 2022)

Modified effects of air pollutants on the relationship between temperature variability and hand, foot, and mouth disease in Zibo City, China - Chunyu Li; Yuchen Zhu; Kaili She; Yan Jia; Tingxuan Liu; Chuang Han; Qidi Fang; Chuanlong Cheng; Luyi Han; Ying Liu; Ying Zhang; Xiujun Li (Environmental Science and Pollution Research, 2022)

Characteristics of a capnophilic small colony variant of Escherichia coli co-isolated with two other strains from a patient with bacteremia in China - Shuo Gao; Zhifeng Zhang; Xuejing Xu; Hui Zhou; Hong Zhu; Yan Zhang; Xiaoli Cao; Wanqing Zhou; Han Shen (Archives of Microbiology, 2022)

Toxic encephalopathy induced by radix Sophorae tonkinensis - Xue-Lin Li; Hao-Tian Zhao; Jinming Han; Zhong-Rui Yan; Hai-Yang Wang (Acta Neurologica Belgica, 2022)

Spatial asynchrony matters more than alpha stability in stabilizing ecosystem productivity in a large temperate forest region - Xuetao Qiao; Yan Geng; Chunyu Zhang; Zhuoxiu Han; Zhonghui Zhang; Xiuhai Zhao; Klaus von Gadow (Global Ecology and Biogeography, 2022)
Aim Understanding the biodiversity–stability relationship has become a central issue in ecology and conservation biology. Although the stabilizing effects of tree species diversity on ecosystem productivity are well recorded in small local communities, they remain poorly understood across scales (from local to larger spatial scales). This study evaluates biodiversity–stability effects from local to larger spatial scales in a large temperate forest region, considering a range of environmental conditions and environmental heterogeneity. Location North‐eastern China ( c . 700,000 km 2 ). Time period 2005–2017. Major taxa studied Woody plants. Methods We define stability as the temporal invariability of biomass productivity. Regional metacommunities representing larger spatial scales were developed by aggregating multiple sets of local field plots. Simple regression analysis was used to test biodiversity–stability relationships in metacommunities. Piecewise structural equation modelling was then used to disentangle the effects of diversity and abiotic variables on forest stability at local and larger spatial scales. Multiple mixed‐effects regression models were used to determine the relative contribution of individual predictive variables to stability across spatial scales. Results We found that local diversity (alpha diversity) was positively related to the stability of local communities (alpha stability), whereas species turnover across space (beta diversity) was positively related to asynchronous dynamics among local communities (spatial asynchrony), regardless of whether abiotic factors were considered or not. We also found that environmental conditions and environmental heterogeneity affected forest stability across scales. The effect of spatial asynchrony on gamma stability was greater than that of alpha stability. Main conclusions Our results imply that spatial asynchrony is a key to maintaining the stability of ecosystem productivity within a large temperate forest region. We suggest that diverse forests and heterogeneous landscapes should be sustained at multiple spatial scales to buffer the negative effects of climate change and forest degradation.

The regulation of shrimp metabolism by the white spot syndrome virus (WSSV) - Ramya Kumar; Jiun‐Yan Huang; Yen‐Siong Ng; Cong‐Yan Chen; Han‐Ching Wang (Reviews in Aquaculture, 2022)
For more than three decades, infectious diseases have been one of the major causes of economic losses in the global shrimp industry. One of the deadliest of the shrimp pathogens is white spot syndrome virus (WSSV), which causes mass mortality in farmed shrimp. Various aspects of WSSV pathogenicity have been studied, but in this review, we will focus only on one of them, namely metabolic reprogramming. WSSV’s modulation of host metabolism affects glycolysis, the tricarboxylic acid (TCA) cycle, glutaminolysis and lipid metabolism. Several signaling pathways are involved in this regulation, including JAK‐STAT, PI3K‐AKT‐mTOR, MAPK and Ras‐Raf‐MEK, with the PI3K‐Akt‐mTOR pathway in particular playing a critical role in activating the WSSV‐induced Warburg effect. Taken together, these changes benefit the virus by facilitating WSSV replication. In this review, we summarize current knowledge regarding the metabolism‐related aspects of WSSV pathogenesis, and discuss the mechanisms by which this virus reprograms its host's metabolic pathways. A deeper understanding of these pathways, key metabolic enzymes and signaling mechanisms is potentially important for the development of effective anti‐WSSV strategies.

Assessing the Resilience of the Marine Economy: A Case Study of Southern China’s Marine Economy Circle - Yue Hu; Han Qian Zhou; Xiao Mei Jin; Ya Fang Shen; Yong Zhe Yan (Frontiers in Marine Science, 2022)
As an important part of the national economy, the marine economy will be subject to various internal and external disturbances in the process of development. Different regions will show different resilience. Based on four dimensions of “resistance–recovery–reorientation–renewal,” this paper measures the marine economic resilience of the four provinces covered within the China’s Southern Marine Economy Circle from 2008 to 2018 by establishing an evaluation index system. The results show that 1) the overall resilience of economy in the Southern Marine Economy Circle showed a fluctuating upward trend from 2008 to 2018. Although there was a decline in 2011–2012 due to natural disasters, the value quickly resumed its increasing trend. 2) At present, there are obvious relative differences in the resilience of marine economy in each region of China’s Southern Marine Economy Circle, and the polarization phenomenon is serious. Among them, Guangdong belongs to the high-value region and Fujian is in the middle, while Hainan and Guangxi are temporarily in the low-value area.

Early stem growth mutation alters metabolic flux changes enhance sesquiterpenoids biosynthesis in Atractylodes lancea (Thunb.) DC. - Di Wang; Fei Chen; Chun-Yan Wang; Xu Han; Chuan-Chao Dai (Plant Cell, Tissue and Organ Culture (PCTOC), 2022)

SOCE-mediated NFAT1–NOX2–NLRP1 inflammasome involves in lipopolysaccharide-induced neuronal damage and Aβ generation - Zhenghao Sun; Xuewang Li; Liu Yang; Xianan Dong; Yuli Han; Yan Li; Jing Luo; Weizu Li (Molecular Neurobiology, 2022)

The Epigenetic Regulation of OLIG2 by Histone Demethylase KDM6B in Glioma Cells - Aixia Sui; Biaogang Han; Wenjun Ren; Weiliang He; Chao Gao; Xiaohui Han; Shifeng Liu; Yan Zhang; Xueling Qi; Xiaoqiang Guo (Journal of Molecular Neuroscience, 2022)

Experimental investigation on hydrate dissociation in near-wellbore region caused by invasion of drilling fluid: ultrasonic measurement and analysis - Qingchao Li; Yuanfang Cheng; Ubedullah Ansari; Ying Han; Xiao Liu; Chuanliang Yan (Environmental Science and Pollution Research, 2022)

Variation of mercury fractionation and speciation in municipal sewage treatment plant: effects of mercury on the atmosphere - Yunpeng Li; Yan Wang; Ruhai Liu; Long Shao; Xiaoyu Liu; Kun Han; Peng Song (Environmental Science and Pollution Research, 2022)

The impact of high-tech product export trade on regional carbon performance in China: the mediating roles of industrial structure supererogation, low-carbon technological innovation, and human capital accumulation - Miao Han; Yan Zhou (Environmental Science and Pollution Research, 2022)

Analysis and Health Risk Assessment of Potentially Toxic Elements in Three Codonopsis Radix Varieties in China - Ruibin Bai; Yanping Wang; Yajie Zhang; Yan Wang; Jiabing Han; Zixia Wang; Jing Zhou; Fangdi Hu (Biological Trace Element Research, 2022)

Microfossil analysis of dental calculus and isotopic measurements reveal the complexity of human-plant dietary relationships in Late Bronze Age Yunnan - Tingting Wang; Dong Wei; Zhilong Jiang; Xiumin Xia; Yan Wu; Zhen Han; Yating Qu; Yaowu Hu; Benjamin T. Fuller (Archaeological and Anthropological Sciences, 2022)

Chemical constituents of Viscum coloratum (Kom.) Nakai and their cytotoxic activities - Ying-Ying Chen; Jiang-Ping Hou; Ling Huang; Afsar Khan; Fei-Fei Xing; Xiao-Han Zhang; De-Feng Han; Shi-Li Yan; Gui-Dong Cao; Qi-Yang Jiao; Dejie Liu; Xuwei Zhu; et al. (Natural Product Research, 2022)

Effects of the Parameter C4ε in the Extended k-ε Turbulence Model for Wind Farm Wake Simulation Using an Actuator Disc - Ning Li; Li Li; Yongqian Liu; Yulu Wu; Hang Meng; Jie Yan; Shuang Han (Journal of Marine Science and Engineering, 2022)
The actuator disc model (ADM) incorporated into the k-ε turbulence model of EI Kasmi is able to simulate the wind farm wakes with high fidelity, which is essential for layout optimization and the evaluation of power production in modern wind farms. However, the effects of the parameter C4ε in the k-ε model of EI Kasmi on turbulent kinetic energy (TKE) in the superposition areas and the recovery of wind farm wake velocity have rarely been studied. To this end, the k-ε model of EI Kasmi is coupled with the advanced ADM in PHOENICS to investigate the influence of the parameter C4ε on the wake simulation of wind farms (e.g., two offshore wind farms, one onshore wind farm). It is concluded that a decreased parameter C4ε makes the generation range of TKE in the vicinity of the rotor smaller, but the TKE near the rotor becomes larger, and the wake recovery rate of the downstream turbine is less affected by the near wake. As the interwind turbine spacing increases, the influence area of TKE in the wake region of each downstream machine gradually reduces, and atmospheric turbulence plays a dominant role in wake recovery. A decreased parameter C4ε can effectively promote the inflow wind velocity and power output of downstream turbines. The power output simulated compares well with the measured power value when the parameter C4ε = 0.15.

Curcumin Inhibits Cell Damage and Apoptosis Caused by Thapsigargin-Induced Endoplasmic Reticulum Stress Involving the Recovery of Mitochondrial Function Mediated by Mitofusin-2 - He-Yan Zhou; Yu-Ying Sun; Ping Chang; Han-Chang Huang (Neurotoxicity Research, 2022)

Targeting GATA1 and p2x7r Locus Binding in Spinal Astrocytes Suppresses Chronic Visceral Pain by Promoting DNA Demethylation - Yan-Yan Wu; Hai-Long Zhang; Xiaomin Lu; Han Du; Yong-Chang Li; Ping-An Zhang; Guang-Yin Xu (Neuroscience Bulletin, 2022)
Irritable bowel syndrome is a gastrointestinal disorder of unknown etiology characterized by widespread, chronic abdominal pain associated with altered bowel movements. Increasing amounts of evidence indicate that injury and inflammation during the neonatal period have long-term effects on tissue structure and function in the adult that may predispose to gastrointestinal diseases. In this study we aimed to investigate how the epigenetic regulation of DNA demethylation of the p2x7r locus guided by the transcription factor GATA binding protein 1 (GATA1) in spinal astrocytes affects chronic visceral pain in adult rats with neonatal colonic inflammation (NCI). The spinal GATA1 targeting to DNA demethylation of p2x7r locus in these rats was assessed by assessing GATA1 function with luciferase assay, chromatin immunoprecipitation, patch clamp, and interference in vitro and in vivo . In addition, a decoy oligodeoxynucleotide was designed and applied to determine the influence of GATA1 on the DNA methylation of a p2x7r CpG island. We showed that NCI caused the induction of GATA1, Ten-eleven translocation 3 (TET3), and purinergic receptors (P2X7Rs) in astrocytes of the spinal dorsal horn, and demonstrated that inhibiting these molecules markedly increased the pain threshold, inhibited the activation of astrocytes, and decreased the spinal sEPSC frequency. NCI also markedly demethylated the p2x7r locus in a manner dependent on the enhancement of both a GATA1–TET3 physical interaction and GATA1 binding at the p2x7r promoter. Importantly, we showed that demethylation of the p2x7r locus (and the attendant increase in P2X7R expression) was reversed upon knockdown of GATA1 or TET3 expression, and demonstrated that a decoy oligodeoxynucleotide that selectively blocked the GATA1 binding site increased the methylation of a CpG island in the p2x7r promoter. These results demonstrate that chronic visceral pain is mediated synergistically by GATA1 and TET3 via a DNA-demethylation mechanism that controls p2x7r transcription in spinal dorsal horn astrocytes, and provide a potential therapeutic strategy by targeting GATA1 and p2x7r locus binding.

Remediation of 1,2-dichlorobenzene contaminated soil by activated persulfate using green synthesized nanoscale zero valent iron: activation mechanism and degradation pathways - Jingchun Yan; Linchao Hu; Weiguo Gao; Lei Yang; Linbo Qian; Lu Han; Mengfang Chen (Journal of Soils and Sediments, 2022)

Circ_0003159 upregulates LIFR expression through competitively binding to miR-221-3p/miR-222-3p to block gastric cancer development - Liansheng Zheng; Boshi Yan; Guoliang Jin; Weijie Han; Hailong Wang; Zhepeng Wang; Yongqiang Ma; Yuanyuan Nian; Xianmei Meng; Zhenyu Jiang (Journal of Molecular Histology, 2022)

Dihydroartemisinin ameliorates chronic nonbacterial prostatitis and epithelial cellular inflammation by blocking the E2F7/HIF1α pathway - Yan Zhou; Jun-hao Wang; Jian-peng Han; Jian-yong Feng; Kuo Guo; Fei Du; Wen-bin Chen; Yong-zhang Li (Inflammation Research, 2022)

Rapid and sensitive detection of Karenia mikimotoi by loop-mediated isothermal amplification combined with a lateral flow dipstick - Xiaotian Han; Ting Zhao; Tian Yan; Rencheng Yu (Environmental Science and Pollution Research, 2022)

Evaluation of the effects of three different cooling methods on the dynamic mechanical properties of thermal-treated sandstone - Lifeng Fan; Han Li; Yan Xi (Bulletin of Engineering Geology and the Environment, 2022)

Lanthanum Impairs Learning and Memory by Activating Microglia in the Hippocampus of Mice - Licheng Yan; Jinghua Yang; Miao Yu; Wenchang Sun; Yarao Han; Xiaobo Lu; Cuihong Jin; Shengwen Wu; Yuan Cai (Biological Trace Element Research, 2022)

Combined overexpression of four transcription factors promotes effector T cell dedifferentiation toward early phenotypes - Lijun Yan; Yusheng Ou; Shengfang Xia; Jianqing Huang; Wenfeng Zhang; Hongwei Shao; Han Shen; Huaben Bo; Changli Tao; Jinquan Wang; Fenglin Wu (Immunogenetics, 2022)

Seasonal Responses of Net Primary Productivity of Vegetation to Phenological Dynamics in the Loess Plateau, China - Hongzhu Han; Jianjun Bai; Gao Ma; Jianwu Yan; Xiaohui Wang; Zhijie Ta; Pengtao Wang (Chinese Geographical Science, 2022)

Early changes to the extracellular space in the hippocampus under simulated microgravity conditions - Yajuan Gao; Hongbin Han; Jichen Du; Qingyuan He; Yanxing Jia; Junhao Yan; Hui Dai; Bin Cui; Jing Yang; Xunbin Wei; Liu Yang; Rui Wang; et al. (Science China Life Sciences, 2022)

Baicalin attenuates amyloid β oligomers induced memory deficits and mitochondria fragmentation through regulation of PDE-PKA-Drp1 signalling - Hai-Yang Yu; Ye Zhu; Xin-Li Zhang; Lei Wang; Yan-Meng Zhou; Fang-Fang Zhang; Han-Ting Zhang; Xiao-Min Zhao (Psychopharmacology, 2022)

Overexpression of Polypogon fugax Type I–Like MADS-Box Gene PfAGL28 Affects Flowering Time and Pod Formation in Transgenic Arabidopsis - Feng-Yan Zhou; Yun-Jing Han; Yan-Hui Wang; Chuan-Chun Yao; Yong Zhang (Plant Molecular Biology Reporter, 2022)

Aligned Organization of Synapses and Mitochondria in Auditory Hair Cells - Jing Liu; Shengxiong Wang; Yan Lu; Haoyu Wang; Fangfang Wang; Miaoxin Qiu; Qiwei Xie; Hua Han; Yunfeng Hua (Neuroscience Bulletin, 2022)

Polysaccharide Krestin Prevents Alzheimer’s Disease-type Pathology and Cognitive Deficits by Enhancing Monocyte Amyloid-β Processing - Si-Han Chen; Chen-Yang He; Ying-Ying Shen; Gui-Hua Zeng; Ding-Yuan Tian; Yuan Cheng; Man-Yu Xu; Dong-Yu Fan; Cheng-Rong Tan; An-Yu Shi; Xian-Le Bu; Yan-Jiang Wang (Neuroscience Bulletin, 2022)

Tidal currents in the coastal waters east of Hainan Island in winter - Min Li; Lingling Xie; Xiaolong Zong; Junyi Li; Mingming Li; Tong Yan; Ronglei Han (Journal of Oceanology and Limnology, 2022)

Analysis and Research on Blasting Network Delay of Deep-Buried Diversion Tunnel Crossing Fault Zone Based on EP-CEEMDAN-INHT - Jing Wu; Li Wu; Miao Sun; Ya-ni Lu; Yan-hua Han (Geotechnical and Geological Engineering, 2022)

Electrochemically activated peroxymonosulfate for the abatement of chloramphenicol in water: performance and mechanism - Yu-Qiong Gao; Jin-Qiang Zhou; Han Ning; Yan-Yan Rao; Nai-Yun Gao (Environmental Science and Pollution Research, 2022)

Pore-scale study on the characteristic hydraulic conductivity of a dispersive lean clay affected by salinity and freeze–thaw - Yan Han; Qing Wang; Jing Liu; Weitong Xia; Jiaqi Wang; Jiejie Shen; Yating Chen (Bulletin of Engineering Geology and the Environment, 2022)

Consistency correction of echo intensity data for multiple radar systems and its application in quantitative estimation of typhoon precipitation - Shuai Zhang; Jing Han; Bingke Zhao; Zhigang Chu; Jie Tang; Limin Lin; Xiaoqin Lu; Jiaming Yan (Frontiers of Earth Science, 2022)

Numerical simulation of water inrush in a tunnel crossing faults: impacts of fault width, damage zone width, and fault permeability - Jing Wu; Xintong Wang; Li Wu; Ya-ni Lu; Yan-hua Han (Arabian Journal of Geosciences, 2022)

Extracellular Vesicle Application as a Novel Therapeutic Strategy for Ischemic Stroke - Yiyang Li; Bowen Liu; Ying Chen; Xingping Quan; Yan Han; Ying Zheng; Yonghua Zhao (Translational Stroke Research, 2022)

Shifting from homogeneous to heterogeneous surfaces in estimating terrestrial evapotranspiration: Review and perspectives - Yuanbo Liu; Guoyu Qiu; Hongsheng Zhang; Yonghui Yang; Yinsheng Zhang; Quan Wang; Wenzhi Zhao; Li Jia; Xibin Ji; Yujiu Xiong; Chunhua Yan; Ning Ma; et al. (Science China Earth Sciences, 2022)

Notch activation suppresses endothelial cell migration and sprouting via miR-223-3p targeting Fbxw7 - Ruonan Wang; Ziyan Yang; Liang Liang; Xingxing Feng; Bo Che; Xiaoyan Zhang; Qijun Zheng; Xianchun Yan; Hua Han (In Vitro Cellular & Developmental Biology - Animal, 2022)

Utility of a pharmacogenetic-driven algorithm in guiding dual antiplatelet therapy for patients undergoing coronary drug-eluting stent implantation in China - Si-qi Lyu; Jun Zhu; Juan Wang; Shuang Wu; Han Zhang; Xing-hui Shao; Yan-min Yang (European Journal of Clinical Pharmacology, 2022)

Does the institutional environment influence corporate social responsibility? Consideration of green investment of enterprises—evidence from China - Shu-Rong Han; Pei Li; Jian-Jun Xiang; Xiang-Hua Luo; Chun-Yan Chen (Environmental Science and Pollution Research, 2022)

Oxygen isotope temperature calibrations for modern Tridacna shells in western Pacific - Guozhen Wang; Hong Yan; Chengcheng Liu; Tao Han; Pengchao Zhou; Nanyu Zhao; Hanfeng Wen; Haobai Fei; John Dodson (Coral Reefs, 2022)

Description of different cracking processes affecting dispersive saline soil slopes subjected to the effects of frost and consequences for the stability of low slopes - Mengxia Han; Qing Wang; Yan Han; Huicheng Fu; Jiejie Shen; Yaowu Liu (Bulletin of Engineering Geology and the Environment, 2022)

GATA4 Is a Transcriptional Regulator of SOX2 in Japanese Flounder (Paralichthys olivaceus) - Xiumei Liu; Zan Li; Weijie Yan; Haitao Zhao; Yuxiang Liu; Miao Han; Xubo Wang; Yan He; Haiyang Yu; Quanqi Zhang (Journal of Ocean University of China, 2022)

Progressive multifocal leukoencephalopathy and peripheral neuropathy in a patient with Good’s syndrome - Qinqin Deng; Zhaofen Yan; Yujiao Yang; Jing Wang; Yixian Han; Xing Feng; Minghui Wang; Liping Zhang; Mengyang Wang (Journal of NeuroVirology, 2022)

TERT Gene rs2736100 and rs2736098 Polymorphisms are Associated with Increased Cancer Risk: A Meta-Analysis - Xinyu Zhang; Yan Chen; Donglin Yan; Jing Han; Longbiao Zhu (Biochemical Genetics, 2022)

2328Pollution characteristics, source identification and potential ecological risk of 50 elements in atmospheric particulate matter during winter in Qingdao - Xiaoyu Liu; Yan Wang; Ruhai Liu; Yanyan Zhang; Long Shao; Kun Han; Yuqing Zhang (Arabian Journal of Geosciences, 2022)

Comparative phylogeography of Acanthocalyx (Caprifoliaceae) reveals distinct genetic structures in the Himalaya–Hengduan Mountains - Qi-Yong Mu; Chih-Chieh Yu; Yan Wang; Ting-Shen Han; Hui Wang; Wen-Na Ding; Qiu-Yue Zhang; Shook Ling Low; Quan-Jing Zheng; Chuan Peng; Zheng-Yan Hu; Yao-Wu Xing (Alpine Botany, 2022)

Two new nor -lignans from Selaginella pulvinata (Hook. & Grev.) Maxim and their antihyperglycemic activities - Hua-Wei Lv; Yu-Xia Li; Meng Luo; Jia-Meng Qi; Ze-Fei Fu; Hong-Jian Zhang; Yuan-Qiang Guo; Chu Chu; Han-Bing Li; Ji-Zhong Yan (Natural Product Research, 2022)

Biocompatible chitosan/polyethylene glycol/multi-walled carbon nanotube composite scaffolds for neural tissue engineering - Shengbo Sang; Rong Cheng; Yanyan Cao; Yayun Yan; Zhizhong Shen; Yajing Zhao; Yanqing Han (Journal of Zhejiang University-SCIENCE B, 2022)

The phenolic acids from Oplopanax elatus Nakai stems and their potential photo-damage prevention activity - Yu Han; Dongsheng Cheng; Mimi Hao; Jiejing Yan; Jingya Ruan; Lifeng Han; Yi Zhang; Tao Wang (Journal of Natural Medicines, 2022)

Synthesis and Characterization of Compounds Based on Carbazole and Sulfone Groups - Huixian Jia; Chenghong Feng; Wanfei Han; Yan Xue; Yanren Jin; Dongfeng Li (Journal of Fluorescence, 2022)

Williamsia soli sp. nov., an actinobacterium isolated from soil at a thermal power plant in Yantai, China - Ming-Jing Zhang; Xue-Han Li; Li-Yang Peng; Shuai-Ting Yun; Zhuo-Cheng Liu; Yan-Xia Zhou (Archives of Microbiology, 2022)

Alteribacter salitolerans sp. nov., isolated from a saline-alkaline soil - Shuang Wang; Lei Sun; Manik Prabhu Narsing Rao; Guo-Hong Liu; Pin-Jiao Jin; Zhou-Yan Dong; Zheng-Han Lian; Xiao-Yu Hao; Ming-Yi Zhang; Wen-Jun Li (Archives of Microbiology, 2022)

Effects of different compaction methods on the performance of reinforced earth retaining wall - Lihua Li; Chengbin Fan; Han Yan; Hang Li; Xinlong Zhou; Na Chen; Jie Huang; Zhi Chen (Arabian Journal of Geosciences, 2022)

Lathyrane diterpenoids from Jatropha podagrica and their antitumor activities in human osteosarcoma cells - Han-Tao Yuan; Qun-Feng Li; Tian Tian; Chun-Yan Zhang; Zou-Qin Huang; Chun-Xiang Fan; Ke Mei; Jie Zhou; Xiao-Xiang Zhai; Si-Bo Li; Jian-Yong Zhu (Natural Product Research, 2021)

Evaluation of the Crack Propagation Capacity of Hard Rock Based on Stress-Induced Deformation Anisotropy and the Propagation Angle of Volumetric Strain - Qiang Han; Xia-Ting Feng; Chengxiang Yang; Rui Kong; Jun Zhao; Yan Zhang (Rock Mechanics and Rock Engineering, 2021)

Study on Dynamic Characteristics of Diorite Under Dry–Wet Cycle - Jiangbo Xu; Haohui Sun; Yilun Cui; Dongyang Fei; Hengxing Lan; Changgen Yan; Han Bao; Faquan Wu (Rock Mechanics and Rock Engineering, 2021)

Quantitative proteomic and lipidomics analyses of high oil content GmDGAT1-2 transgenic soybean illustrate the regulatory mechanism of lipoxygenase and oleosin - Yang Xu; Fan Yan; Yajing Liu; Ying Wang; Han Gao; Shihui Zhao; Youcheng Zhu; Qingyu Wang; Jingwen Li (Plant Cell Reports, 2021)

Role of the PD‐1/PD‐L1 Signaling in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Recent Insights and Future Directions - Yan Mi; Jinming Han; Jie Zhu; Tao Jin (Molecular Neurobiology, 2021)
Multiple sclerosis (MS) is an autoimmunity-related chronic demyelination disease of the central nervous system (CNS), causing young disability. Currently, highly specific immunotherapies for MS are still lacking. Programmed cell death 1 (PD-1) is an immunosuppressive co-stimulatory molecule, which is expressed on activated T lymphocytes, B lymphocytes, natural killer cells, and other immune cells. PD-L1, the ligand of PD-1, is expressed on T lymphocytes, B lymphocytes, dendritic cells, and macrophages. PD-1/PD-L1 delivers negative regulatory signals to immune cells, maintaining immune tolerance and inhibiting autoimmunity. This review comprehensively summarizes current insights into the role of PD-1/PD-L1 signaling in MS and its animal model experimental autoimmune encephalomyelitis (EAE). The potentiality of PD-1/PD-L1 as biomarkers or therapeutic targets for MS will also be discussed.

TUG1 knockdown suppresses cardiac fibrosis after myocardial infarction - Qingsong Sun; Man Luo; Zhiwei Gao; Xiang Han; Zhuan Yan; Shouxiang Xie; Hongmei Zhao; Hong Sun (Mammalian Genome, 2021)

Effects of Nitrogen Fertilizer Applications on Photosynthetic Production and Yield of Japonica Rice - Chanchan Zhou; Baoyan Jia; Shu Wang; Yuancai Huang; Yan Wang; Kai Han; Wendi Wang (International Journal of Plant Production, 2021)

Pollution characteristics, spatial distribution, and source identification of heavy metals in road dust in a central eastern city in China: a comprehensive survey - Guoyong Zhao; Ronglei Zhang; Yan Han; Jianing Meng; Qiang Qiao; Hetan Li (Environmental Monitoring and Assessment, 2021)

Abdominal Massage Alleviates Skeletal Muscle Insulin Resistance by Regulating the AMPK/SIRT1/PGC-1α Signaling Pathway - Yiran Han; Zeyuan Lu; Shaotao Chen; Chongwen Zhong; Minghui Yan; Heran Wang; Meng Meng; Mingjun Liu (Cell Biochemistry and Biophysics, 2021)
Abdominal massage (AM), a traditional Chinese medicine-based treatment method, has received considerable attention in the recent years. The aim of the present study was to investigate the effect of AM on high-fat diet (HFD)-induced insulin resistance (IR) in comparison with resveratrol (RSV) treatment. Forty-eight male Sprague-Dawley rats were randomly divided into the following four groups: standard chow diet (control group), high-fat diet (model group), HFD + abdominal massage (AM group), and HFD + resveratrol (RSV group). A rat model of IR was established by feeding HFD to rats for 8 weeks followed by treatment with AM or RSV for 4 weeks. The underlying HFD-induced IR molecular mechanisms were studied in rat serum and skeletal muscles. RSV and AM significantly improved glucose intolerance, hyperglycemia, obesity, and significantly reduced lipid accumulation [triglyceride (TC), total cholesterol (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C)], adipocytokine [free fatty acids (FFA), adiponectin (ADPN)] and serum pro-inflammatory cytokines (IL-6 and TNF-α) secretion. In addition, AM activated the AMPK/SIRT1 signaling pathway in rat skeletal muscle. In conclusion, our results showed that AM could improve IR by regulating the secretion of adipocytokines, pro-inflammatory cytokines as well as related signaling pathways in the skeletal muscle of rats, which might provide insights into development of new treatment methods for the clinical treatment of IR.

Erratum to: Settlement patterns of mountainous half-filled and half-cut widened subgrade with retaining wall - Yong-guo Fu; Xin Jiang; Han-yan Gu; Yan-jun Qiu (Journal of Mountain Science, 2021)

Complete genome sequence of a putative novel ilarvirus isolated from Eleocharis dulcis - Lanqing Lv; Xinyang Wu; Jiajia Weng; Yuchao Lai; Kelei Han; Yuwen Lu; Jiejun Peng; Lin Lin; Shaofei Rao; Guanwei Wu; Jianping Chen; Hongying Zheng; et al. (Archives of Virology, 2021)

Molecular identification and phylogenetic analysis of fungal pathogens isolated from diseased fish in Xinjiang, China - Yan‐Zhen Zhang; Qing‐Dian Han; Long‐Wei Fu; Yong‐Xing Wang; Zhi‐Hai Sui; Yun‐Guo Liu (Journal of Fish Biology, 2021)
The outbreaks of fungal diseases in cultured fish have been severe in recent years, which is harmful to the healthy and sustainable development of fish farming. In this study, an investigation was conducted for significant fungal infections of 12 species of fish in four regions in Xinjiang, China, to understand the distribution of local fish fungal pathogens. Twenty‐six fungal strains with pathogenicity were isolated, and the challenge experiment showed that eight strains from Changji area had high infection rate to fish eggs. Based on internal transcribed spacer sequence data and molecular analysis, the 26 strains were classified into nine different species of six fungal genera. Phylogenetic analysis showed that all strains were divided into two clades, namely Cluster 1 (contains only the genus Mucor ) and Cluster 2 (consists of five small branches), and the distribution of strains from the same region was scattered in two clusters. There is no strict host selectivity for these fungi to infect fish. Mucor sp. are the main fungal pathogen of fish in these four regions, whereas Hypophthalmichthys molitrix and Carassius auratus are two types of fish that were susceptible to pathogen. In addition, the environmental adaptability experiments showed that eight highly pathogenic strains have different adaptability to the environment, and their optimum temperature and pH were 25°C and 7.0, respectively, whereas the concentration of NaCl was negatively correlated with the growth of strains. Therefore, these results indicated that the coinfection of multiple fungal pathogens in a culture region should be considered in the future study.

Three new diterpenoids from Euphorbia peplus - Yan-Ni Chen; Qing-Yun Lu; Dong-Mei Li; Ying-Yao Li; Xue-Xue Pu; Bo-Ting Li; Xiao-Han Tang; Hong-Yu Tang; Shuai Liu; Lei Yang; Yu Zhang; Ying-Tong Di; et al. (Natural Product Research, 2021)

Loganin ameliorates depression-like behaviors of mice via modulation of serotoninergic system - Chen-Hao Pan; Cong-Yuan Xia; Yu Yan; Yan Han; Rui Shi; Jun He; Ze-Xing Wang; Yu-Ming Wang; Wei-Ku Zhang; Jie-Kun Xu (Psychopharmacology, 2021)

GhWRKY21 regulates ABA-mediated drought tolerance by fine-tuning the expression of GhHAB in cotton - Jiayu Wang; Lijun Wang; Yan Yan; Shuxin Zhang; Han Li; Zheng Gao; Chen Wang; Xingqi Guo (Plant Cell Reports, 2021)

Fouling characteristics of cnidarians (Hydrozoa and Anthozoa) along the coast of China - Tao Yan; Mingqing Lin; Wenhao Cao; Shuaishuai Han; Xikun Song (Journal of Oceanology and Limnology, 2021)

Comparative transcriptome analysis reveals that deletion of CheY influences gene expressions of ABC transports and metabolism in Haemophilus parasuis - Lvqin He; Xuefeng Yan; Ke Dai; Xintian Wen; Sanjie Cao; Xiaobo Huang; Rui Wu; Qin Zhao; Yong Huang; Qigui Yan; Xiaoping Ma; Xinfeng Han; et al. (Functional & Integrative Genomics, 2021)

Pepsinogen C expression–related lncRNA/circRNA/mRNA profile and its co-mediated ceRNA network in gastric cancer - Li-rong Yan; Han-xi Ding; Shi-xuan Shen; Xiao-dong Lu; Yuan Yuan; Qian Xu (Functional & Integrative Genomics, 2021)

Comparative activities of sitafloxacin against recent clinical isolates in hospitals across China - Shi Wu; Yang Yang; Yan Guo; Dandan Yin; Yonggui Zheng; Renru Han; Li Ding; Demei Zhu; Fupin Hu (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Characteristics of ambient ammonia and its effects on particulate ammonium in winter of urban Beijing, China - Rui Zhang; Yuhua Han; Aijun Shi; Xuesong Sun; Xiao Yan; Yuhu Huang; Yu Wang (Environmental Science and Pollution Research, 2021)

Eutrophication model driven by light and nutrients condition change in sluice-controlled river reaches - Ming Dou; Li Liang; Yuping Han; Ruipeng Jia; Yan Zhang (Environmental Science and Pollution Research, 2021)

Correlation between the positive rate of SAA in children with respiratory tract infection and ambient temperature - Shanshui Zeng; Mengru Han; Fei Liu; Yan Long; Ming Jiang; Hongling Yang (Environmental Science and Pollution Research, 2021)

The mechanism of mudstone skin friction of large-diameter and long piles based on the pile test of the Longhua Songhua River Bridge in Jilin Province, China - Yan Xu; Fansheng Kong; Kang Gao; Zhongjun Hu; Lingmin Han (Arabian Journal of Geosciences, 2021)

Echinicola salinicaeni sp. nov., a novel bacterium isolated from saltern mud - Han Zhao; Chun-Yi Song; Rui Yin; Yan-Jun Yi; Shuai-Ting Yun; Ying-Xiu Li; Yan-Xia Zhou (Antonie van Leeuwenhoek, 2021)

Influences of the Great Whirl on surface chlorophyll a concentration off the Somali Coast in 2017 - Lingxing Dai; Bing Han; Shilin Tang; Chuqun Chen; Yan Du (Acta Oceanologica Sinica, 2021)

Two new cephalochromin derivative from the Alternaria sp. ZG22 - Xin-Ming Song; Xue-Ming Zhou; Ya-Ling Li; Li-Bing Huang; Cai-Cui Chen; Yan Gao; Lin He; Xiao-qun Mao; Bing Chen; Jing-Wen Liu; Hui-Jie Liu; Xiao-Ping Song; et al. (Natural Product Research, 2021)

Master regulator NtrC controls the utilization of alternative nitrogen sources in Pseudomonas stutzeri A1501 - Zhimin Yang; Qin Li; Yongliang Yan; Xiubin Ke; Yueyue Han; Shaoyu Wu; Fanyang Lv; Yahui Shao; Shanshan Jiang; Min Lin; Yunhua Zhang; Yuhua Zhan (World Journal of Microbiology and Biotechnology, 2021)
Pseudomonas stutzeri A1501 is a model strain used to study associative nitrogen fixation, and it possesses the nitrogen regulatory NtrC protein in the core genome. Nitrogen sources represent one of the important factors affecting the efficiency of biological nitrogen fixation in the natural environment. However, the regulation of NtrC during nitrogen metabolism in P. stutzeri A1501 has not been clarified. In this work, a phenotypic analysis of the ntrC mutant characterized the roles of NtrC in nitrogen metabolism and the oxidative stress response of P. stutzeri A1501. To systematically identify NtrC-controlled gene expression, RNA-seq was performed to further analyse the gene expression differences between the wild-type strain and the ∆ ntrC mutant under nitrogen fixation conditions. A total of 1431 genes were found to be significantly altered by ntrC deletion, among which 147 associative genes had NtrC-binding sites, and the pathways for nitrogen fixation regulation, nitrogenous compound acquisition and catabolism and nitrate assimilation were discussed. Furthermore, the oxidative stress-related gene ( katB ), which was upregulated by ntrC deletion, was suggested to be a potential target gene of NtrC, thus highlighting the importance of NtrC in nitrogenase protection against oxygen damage. Based on these findings, we propose that NtrC is a high-ranking element in the regulatory network of P. stutzeri A1501 that controls a variety of nitrogen metabolic and oxidative stress responsive traits required for adaptation to complex rhizosphere environments.

Expression of the SPL-like gene LaSPL9 in Japanese larch (Larix leptolepis) is regulated by miR156 during somatic embryogenesis - Li-feng Zhang; Yan-ru Fan; Qian Lan; Li-wang Qi; Su-ying Han (Trees, 2021)

Interdecadal variations of persistent extreme heat events in eastern China under global warming - Naihui Zang; Junhu Zhao; Pengcheng Yan; Han Zhang; Shankai Tang; Guolin Feng (Theoretical and Applied Climatology, 2021)

3D-printed models improve surgical planning for correction of severe postburn ankle contracture with an external fixator - Youbai Chen; Zehao Niu; Weiqian Jiang; Ran Tao; Yonghong Lei; Lingli Guo; Kexue Zhang; Wensen Xia; Baoqiang Song; Luyu Huang; Qixu Zhang; Yan Han (Journal of Zhejiang University-SCIENCE B, 2021)

Long-term nitrogen addition further increased carbon sequestration in a boreal forest - Guancheng Liu; Guoyong Yan; Mengyu Chang; Binbin Huang; Xingyu Sun; Shijie Han; Yajuan Xing; Qinggui Wang (European Journal of Forest Research, 2021)

Diversity, abundance, and distribution of anammox bacteria in shipping channel sediment of Hong Kong by analysis of DNA and RNA - Xiaowei Zhang; Han Meng; Yuchun Yang; Wensheng Lan; Weidong Wang; Paul K. S. Lam; Xiao-Yan Li; Ji-Dong Gu (Ecotoxicology, 2021)

Association of myostatin deficiency with collagen related disease-umbilical hernia and tippy toe standing in pigs - Hyo-Jin Paek; Zhao-Bo Luo; Hak-Myong Choe; Biao-Hu Quan; Kai Gao; Sheng-Zhong Han; Zhou-Yan Li; Jin-Dan Kang; Xi-Jun Yin (Transgenic Research, 2021)

Settlement patterns of mountainous half-filled and half-cut widened subgrade with retaining wall - Yong-guo Fu; Xin Jiang; Han-yan Gu; Yan-jun Qiu (Journal of Mountain Science, 2021)

Effects on the STAT3-shRNA in Non-Small-Cell Lung Cancer Therapy: Design, Induction of Apoptosis, and Conjugation with Chitosan-Based Gene Vectors - Wangwang Zhang; Yan Zhang; Zhiwen Jiang; Le Sun; Litong Wang; Zhiyang Gu; Wenya Li; Lili Guo; Xiaotong Chen; Haibin Zhang; Baoqin Han; Jing Chang (Journal of Ocean University of China, 2021)

Raspberry (Rubus idaeus L.) NCED1 gene enhances high salinity and cold tolerance in Arabidopsis - Guohui Yang; Yuxiao Chen; Heng Yu; Hang Zhang; Deguo Han; Xiaoyu Guo; Enqing Yan; Hanyi Quan; Tiemei Li (In Vitro Cellular & Developmental Biology - Plant, 2021)

The influence of Stokes drift on oil spills: Sanchi oil spill case - Yiqiu Yang; Yan Li; Juan Li; Jingui Liu; Zhiyi Gao; Kaixuan Guo; Han Yu (Acta Oceanologica Sinica, 2021)

Sesquiterpenoids from Artemisia argyi and their NO production inhibitory activity in RAW264.7 cells - Gui-Min Xue; Jin-Feng Xue; Chen-Guang Zhao; Zhen-Zhu Zhao; Yan-Jun Sun; Kun Du; Han-Wei Li; Wei-Sheng Feng (Natural Product Research, 2021)

Association between large artery stenosis, cerebral small vessel disease and risk of ischemic stroke - Fei Han; Ding-Ding Zhang; Fei-Fei Zhai; Jun Xue; Jiang-Tao Zhang; Shuang Yan; Li-Xin Zhou; Jun Ni; Ming Yao; Meng Yang; Ming-Li Li; Zheng-Yu Jin; et al. (Science China Life Sciences, 2021)

Descending Modulation of Spinal Itch Transmission by Primary Somatosensory Cortex - Zi-Han Wu; Han-Yu Shao; Yuan-Yuan Fu; Xiao-Bo Wu; De-Li Cao; Sheng-Xiang Yan; Wei-Lin Sha; Yong-Jing Gao; Zhi-Jun Zhang (Neuroscience Bulletin, 2021)

Differential DNA Methylation Profiles in Patients with Temporal Lobe Epilepsy and Hippocampal Sclerosis ILAE Type I - Wang Zhang; Haiyang Wang; Binchao Liu; Miaomiao Jiang; Yifei Gu; Shi Yan; Xian Han; Alicia Y. Hou; Chongyang Tang; Zhenfeng Jiang; Hong Shen; Meng Na; et al. (Journal of Molecular Neuroscience, 2021)

Health and economic impacts from PM2.5 pollution transfer attributed to domestic trade in China: a provincial-level analysis - Xueyuan Hu; Han Sun; Xi Luo; Shan Ni; Yingying Yan (Environmental Science and Pollution Research, 2021)

Magnetic monitoring of topsoil and street dust in Xinyang (China) and their environmental implications - Yan Han; Xiuming Liu; Guoyong Zhao; Bin Lü; Qu Chen (Environmental Monitoring and Assessment, 2021)

Apigenin Improves Hypertension and Cardiac Hypertrophy Through Modulating NADPH Oxidase-Dependent ROS Generation and Cytokines in Hypothalamic Paraventricular Nucleus - Hong-Li Gao; Xiao-Jing Yu; Han-Bo Hu; Qian-Wen Yang; Kai-Li Liu; Yan-Mei Chen; Yan Zhang; Dong-Dong Zhang; Hua Tian; Guo-Qing Zhu; Jie Qi; Yu-Ming Kang (Cardiovascular Toxicology, 2021)

Identification and spatial pattern analysis of alpine timberline by remote sensing methods in Yarlung Zangpo Grand Canyon - Bei Zhu; Shi-yan Wang; Wei Su; Kai-qi Chen; Chang Liu; Yan-liang Du; Liang Wang; Zhen Han; Jiang-xiang Zou (Journal of Mountain Science, 2021)

Puerarin protects cardiomyocytes from ischemia–reperfusion injury by upregulating LncRNA ANRIL and inhibiting autophagy - Yanhui Han; Honglei Wang; Yan Wang; Pingshuan Dong; Jingjing Jia; Shaohui Yang (Cell and Tissue Research, 2021)

Correlation of CD38 expression with the progression of hemorrhagic fever with renal syndrome - Han-Dong Zhao; Yan-Ping Li; Wei-Wei Zhao; Peng Li; Hong-Li Liu (Archives of Virology, 2021)

Interaction between the cell walls of microalgal host and fungal carbohydrate‐activate enzymes is essential for the pathogenic parasitism process - Juan Lin; Hailong Yan; Liang Zhao; Yanhua Li; Bahareh Nahidian; Mianmian Zhu; Qiang Hu; Danxiang Han (Environmental Microbiology, 2021)
Summary Fungi can parasitize microalgae, exerting profound impacts on both the aquatic ecosystems and microalgal mass cultures. In this study, the unicellular green alga Haematococcus pluvialis and the blastocladialean fungus Paraphysoderma sedebokerense were used as a model system to address the mechanisms underlying the fungal parasitism on the algal host. High‐throughput metabolic assay indicated that P . sedebokerense can utilize several carbon sources with a preference for mannose, glucose and their oligosaccharides, which was compatible with the profile of the host algal cell walls enriched with glucan and mannan. The results of dual transcriptomics analysis suggested that P . sedebokerense can upregulate a large number of putative carbohydrate‐activate enzymes (CAZymes) encoding genes, including those coding for the endo‐1,4‐β‐glucanase and endo‐1,4‐β‐mannanase during the infection process. The cell walls of H . pluvialis can be decomposed by both P . sedebokerense and commercial CAZymes (e.g. cellulase and endo‐1,4‐β‐mannanase) to produce mannooligomers, while several putative parasitism‐related genes of P . sedebokerense can be in turn upregulated by mannooligomers. In addition, the parasitism can be blocked by interfering the selected CAZymes including glucanase, mannanase and lysozyme with the specific inhibitors, which provided a framework for screening suitable compounds for pathogen mitigation in algal mass culture.

The downregulation of PpPG21 and PpPG22 influences peach fruit texture and softening - Ming Qian; Ze Xu; Zehua Zhang; Qin Li; Xiangyan Yan; Hangkong Liu; Mingyu Han; Furui Li; Jicheng Zheng; Dong Zhang; Caiping Zhao (Planta, 2021)

Secondary Packages cannot Protect Liquid Biopharmaceutical Formulations from Dropping-Induced Degradation - Wei-Jie Fang; Jia-Wei Liu; Han Gao; Yan-Chen Qian; Jian-Qing Gao; Haibin Wang (Pharmaceutical Research, 2021)

Inhibition of Ca2+-dependent protein kinase C rescues high calcium–induced pro-arrhythmogenic cardiac alternans in rabbit hearts - Pei-pei Zhang; Liangkun Hu; You-jia Tian; Zefu Zhang; Pei-hua Zhang; Yan-yan Yang; Shi-han Li; Jihua Ma (Pflügers Archiv - European Journal of Physiology, 2021)

Loop-mediated isothermal amplification and PCR combined assay to detect and distinguish latent Colletotrichum spp. infection on strawberry - Ya Liu; Ying Ji; Yongchao Han; Lili Song; Liqing Zhang; Zhiyuan Ning; Weizhong Yan; Qinghua Gao; Ke Duan (Journal of Plant Pathology, 2021)

Frequency-specific altered global signal topography in drug-naïve first-episode patients with adolescent-onset schizophrenia - Xiao Wang; Wei Liao; Shaoqiang Han; Jiao Li; Yifeng Wang; Yan Zhang; Jingping Zhao; Huafu Chen (Brain Imaging and Behavior, 2021)

Mild encephalitis/encephalopathy with a reversible splenial lesion associated with respiratory syncytial virus infection in infants - Xue-Lin Li; Jinming Han; Zhong-Rui Yan; Bing-Wei Zhang; Hai-Yang Wang (Journal of NeuroVirology, 2021)

Coxsackievirus B4: an underestimated pathogen associated with a hand, foot, and mouth disease outbreak - Jinbo Xiao; Jianxing Wang; Yong Zhang; Dapeng Sun; Huanhuan Lu; Zhenzhi Han; Yang Song; Dongmei Yan; Shuangli Zhu; Yaowen Pei; Wenbo Xu; Xianjun Wang (Archives of Virology, 2021)

Molecular authentication of medicinal and edible plant Gnaphalium affine (cudweed herb, “Shu-qu-cao”) based on DNA barcode marker ITS2 - Mengdi Zheng; Die Liu; Han Zhang; Yan Zhang (Acta Physiologiae Plantarum, 2021)

Shrub‐rings used to reconstruct drought history of the central Alxa desert, northwest China - Ai‐Jun Ding; Sheng‐Chun Xiao; Xiao‐Mei Peng; Quan‐Yan Tian; Chao Han (International Journal of Climatology, 2021)
The climate history of the Alxa desert of northwestern China must be sought both in recent instrumental records (dating from 1960) and in high‐resolution proxy data. Climate proxies are scarce in desert areas; however, long‐lived desert shrubs can offer one such proxy. We have used shrub‐ring data from Zygophyllum xanthoxylum , collected in the central Alxa desert, to reconstruct the Self‐calibrating Palmer Drought Severity Index (scPDSI) for the period 1880–2015. The data covers the May–July growth season. When we compared the history constructed from the shrub‐ring data with the instrumental data collected 1960–2015, we found that the reconstructed history explained 41% of the variance in scPDSI data (40% after adjusting for loss of degrees of freedom). The reconstructed history shows that this region has experienced six persistent droughts and four seasons wetter than usual during the period under study. Of note is a severe drought event in 1920s that affected much of northern China (as noted in contemporary documents). The droughts and wet seasons identified in our reconstruction are consistent with reports from other researchers who have studied the climate history or the region. Our study suggests that it is feasible to reconstruct climate history using shrub‐ring data from long‐lived desert shrubs.

Geochronology and geochemistry of late Jurassic–Early Cretaceous volcanic rocks in the southern Great Xing’an range, NE China: constraints for late Mesozoic tectono-magmatic evolution - Shi-Jiong Han; Xi Wang; Xin Wang; Yan Wang; Yang Zhang (International Geology Review, 2021)

Correction to: TAK1 is involved in sodium L‑lactate‑stimulated p38 signaling and promotes apoptosis - Qingen Da; Zilong Yan; Zhangfu Li; Zhen Han; Mingming Ren; Lei Huang; Xiaowei Zhang; Jikui Liu; Tao Wang (Molecular and Cellular Biochemistry, 2021)

A novel approach to simulating debris flow runout via a three-dimensional CFD code: a case study of Xiaojia Gully - Yansong Zhang; Jianping Chen; Chun Tan; Yiding Bao; Xudong Han; Jianhua Yan; Qaiser Mehmood (Bulletin of Engineering Geology and the Environment, 2021)

Archaeal and bacterial community structures of rural household biogas digesters with different raw materials in Qinghai Plateau - Rui Han; Li Liu; Yan Meng; Hairong Han; Rongbo Xiong; Yi Li; Laisheng Chen (Biotechnology Letters, 2021)

Serum Iron and Ferritin Levels Are Correlated with Complement C3 - Shuang Wen; Yeqin Sha; Yinling Li; Zhilian Rui; Chenhong Si; Yuning Zhou; Fengfeng Yan; Bicheng Wang; Jingming Hu; Xu Han; Dongyan Shi (Biological Trace Element Research, 2021)

2D anisotropic nonslant stack beam migration for multicomponent seismic data - Jianguang Han; Zhiwei Liu; Yun Wang; Jiayong Yan; Bingluo Gu (Arabian Journal of Geosciences, 2021)

Shattering-resistance of an elite soybean variety ‘Heihe 43’ and identification of shattering-resistant genes - Dezhi Han; Jianan Han; Siqi Jiang; Bohong Su; Bo Zhang; Zhangxiong Liu; Hongrui Yan; Li-Juan Qiu (Euphytica, 2021)

Comparison of DEM accuracies generated from different stereo pairs over a plateau mountainous area - Han-hu Liu; Yin-jun Zhao; Lei Wang; Yan-yan Liu (Journal of Mountain Science, 2021)

Fine-grained rock fabric facies classification and its control on shale oil accumulation: a case study from the Paleogene Kong 2 Member, Bohai Bay Basin - Wenzhong Han; Xianzheng Zhao; Xiugang Pu; Shiyue Chen; Hu Wang; Yan Liu; Zhannan Shi; Wei Zhang; Jiapeng Wu (Frontiers of Earth Science, 2021)

A cloud classification method based on random forest for FY-4A - Zhuofu Yu; Shuo Ma; Ding Han; Guanlin Li; Ding Gao; Wei Yan (International Journal of Remote Sensing, 2021)

Identification and functional characterization of a PDR transporter in Tripterygium wilfordii Hook.f. that mediates the efflux of triptolide - Guopeng Miao; Juan Han; Yan-bo Huo; Cheng-run Wang; Shun-chang Wang (Plant Molecular Biology, 2021)

Resolvin D1 Attenuates Innate Immune Reactions in Experimental Subarachnoid Hemorrhage Rat Model - Guang-Jie Liu; Tao Tao; Xiang-Sheng Zhang; Yue Lu; Ling-Yun Wu; Yong-Yue Gao; Han Wang; Hai-Bin Dai; Yan Zhou; Zong Zhuang; Chun-Hua Hang; Wei Li (Molecular Neurobiology, 2021)

Comprehensive evaluation of ecological environment quality of mining area based on sustainable development indicators: a case study of Yanzhou Mining in China - Xiuyan Han; Tianyi Cao; Xinlin Yan (Environment, Development and Sustainability, 2021)

Prediction of oral hepatotoxic dose of natural products derived from traditional Chinese medicines based on SVM classifier and PBPK modeling - Size Li; Yiqun Yu; Xiaolan Bian; Li Yao; Min Li; Yan-Ru Lou; Jing Yuan; Hai-shu Lin; Lucy Liu; Bing Han; Xiaoqiang Xiang (Archives of Toxicology, 2021)

Puerhibacterium puerhi gen. nov., sp. nov., a novel member of the family Promicromonosporaceae, isolated from Pu-erh tea pile-fermentation - Rui-Juan Yang; De Zhou; Qiao-Mei Wang; Lu Han; Wen-Shu Peng; Li Liu; Xuan-Jun Wang; Liang Yan; Jie Lv; Jun Sheng (Archives of Microbiology, 2021)

Estimating cloud base height from Himawari-8 based on a random forest algorithm - Zhonghui Tan; Juan Huo; Shuo Ma; Ding Han; Xin Wang; Shensen Hu; Wei Yan (International Journal of Remote Sensing, 2021)

Changes in the physiological characteristics of Panax ginseng embryogenic calli and molecular mechanism of ginsenoside biosynthesis under cold stress - Tao Zhang; Yan Gao; Mei Han; Linmin Yang (Planta, 2021)

Recanalization Treatment for Acute Stroke: Can We Skip the Bridge? - Wen-Xiao Yu; Shu-Han Huang; Yan-Jiang Wang; Meng Zhang (Neuroscience Bulletin, 2021)

Physical Simulations of Gas Production Mechanism in Constant-Rate Co-production from Multiple Coal Reservoirs - Qixian Li; Jiang Xu; Shoujian Peng; Fazhi Yan; Bin Zhou; Ende Han; Cheng Jiang (Natural Resources Research, 2021)

The prevalence and risks of major comorbidities among inpatients with pulmonary tuberculosis in China from a gender and age perspective: a large-scale multicenter observational study - Wanli Kang; Jian Du; Song Yang; Jiajia Yu; Hongyan Chen; Jianxiong Liu; Jinshan Ma; Mingwu Li; Jingmin Qin; Wei Shu; Peilan Zong; Yi Zhang; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Genome-wide linkage mapping for canopy activity related traits using three RIL populations in bread wheat - Faji Li; Weie Wen; Jindong Liu; Shengnan Zhai; Xinyou Cao; Cheng Liu; Dungong Cheng; Jun Guo; Yan Zi; Ran Han; Xiaolu Wang; Aifeng Liu; et al. (Euphytica, 2021)

The Fe3O4-modified biochar reduces arsenic availability in soil and arsenic accumulation in indica rice (Oryza sativa L.) - Yao Yao; Hang Zhou; Xiu-Lan Yan; Xiao Yang; Kang-Wen Huang; Juan Liu; Li-Juan Li; Jing-Yi Zhang; Jiao-Feng Gu; Yaoyu Zhou; Bo-Han Liao (Environmental Science and Pollution Research, 2021)

Transformation of China’s urbanization and eco-environment dynamics: an insight with location-based population-weighted indicators - Lijian Han; Xiaoyan Zhang; Weiqi Zhou; Miaogen Shen; Yan Huang; Weifeng Li; Yuguo Qian (Environmental Science and Pollution Research, 2021)

Nitrogen Enrichment Reduces Nitrogen and Phosphorus Resorption Through Changes to Species Resorption and Plant Community Composition - Xiao-Tao Lü; Shuang-Li Hou; Sasha Reed; Jiang-Xia Yin; Yan-Yu Hu; Hai-Wei Wei; Zhi-Wei Zhang; Guo-Jiao Yang; Zhuo-Yi Liu; Xing-Guo Han (Ecosystems, 2021)

Construction and experimental analysis of permeability prediction model of unsaturated clay - Yong Wang; Zihan Wang; Han Yan; Shiyu Li; Yunhao Cui (Arabian Journal of Geosciences, 2021)

Summer pruning improves the branch growth and tea quality of tea trees (Camellia sinensis) - Liping Zhang; Menghan Li; Xin Li; Peng Yan; Lan Zhang; Wenyan Han (Acta Physiologiae Plantarum, 2021)

EmhR is an indole‐sensing transcriptional regulator responsible for the indole‐induced antibiotic tolerance in Pseudomonas fluorescens - Jian‐Ting Han; Di‐Yin Li; Meng‐Yuan Zhang; Xiao‐Quan Yu; Xiang‐Xue Jia; Hang Xu; Xu Yan; Wen‐Juan Jia; Shaomin Niu; Megan L. Kempher; Xuanyu Tao; Yong‐Xing He (Environmental Microbiology, 2021)
Summary Indole is well known as an interspecies signalling molecule to modulate bacterial physiology; however, it is not clear how the indole signal is perceived and responded to by plant growth promoting rhizobacteria (PGPR) in the rhizosphere. Here, we demonstrated that indole enhanced the antibiotic tolerance of Pseudomonas fluorescens 2P24, a PGPR well known for its biocontrol capacity. Proteomic analysis revealed that indole influenced the expression of multiple genes including the emhABC operon encoding a major multidrug efflux pump. The expression of emhABC was regulated by a TetR‐family transcription factor EmhR, which was demonstrated to be an indole‐responsive regulator. Molecular dynamics simulation showed that indole allosterically affected the distance between the two DNA‐recognizing helices within the EmhR dimer, leading to diminished EmhR–DNA interaction. It was further revealed the EmhR ortholog in Pseudomonas syringae was also responsible for indole‐induced antibiotic tolerance, suggesting this EmhR‐dependent, indole‐induced antibiotic tolerance is likely to be conserved among Pseudomonas species. Taken together, our results elucidated the molecular mechanism of indole‐induced antibiotic tolerance in Pseudomonas species and had important implications on how rhizobacteria sense and respond to indole in the rhizosphere.

Evaluation Method of Rock Brittleness under True Triaxial Stress States Based on Pre-peak Deformation Characteristic and Post-peak Energy Evolution - Yan Zhang; Xia-Ting Feng; Chengxiang Yang; Qiang Han; Zhaofeng Wang; Rui Kong (Rock Mechanics and Rock Engineering, 2021)

Unraveling Physiological and Metabolomic Responses Involved in Phlox subulata L. Tolerance to Drought Stress - Yan Xiong; Yanting Qu; Hui Han; Fei Chen; Li Li; Huanwei Tang; Daidi Che; Xing Zhang (Plant Molecular Biology Reporter, 2021)

Cloning, characterization, and transcriptional activity of β-actin promoter of African catfish (Clarias gariepinus) - Sanghyok Ri; Wenho Hwang; Sangryong Ri; Wei Shi; Yu Han; Yu Tang; Lining Zhang; Maocang Yan; Guangxu Liu (Molecular Biology Reports, 2021)

2,3,5,6-Tetramethylpyrazine protects retinal photoreceptors against endoplasmic reticulum stress by modulating ATF4-mediated inhibition of PRP aggregation - Hao Huang; Xiaobo Zhu; Hao Cheng; Xielan Kuang; Chongde Long; Xizhi Deng; Yuxiu Zou; Han Zhang; Yue Xing; Xiangtian Ling; Renchun Wang; Han Tang; et al. (Journal of Molecular Medicine, 2021)

Interannual variability of body size and beak morphology of the squid Ommastrephes bartramii in the North Pacific Ocean in the context of climate change - Zhou Fang; Peiwu Han; Yan Wang; Yangyang Chen; Xinjun Chen (Hydrobiologia, 2021)
Oceanic squids are typical species that sensitive to the environment change. Previous studies on oceanic squids mainly focus on its annually fluctuated abundance under the background of climate change. The changes of individual morphological sizes, including body and beak, have been observed in recent years. In this study, Ommastrephes bartramii , an important cephalopod species in North Pacific Ocean, has been selected to analyze the annual morphological changes of body and beak under different scales of climate events. Geometric morphometrics was used to analyze the shape variations of both upper beak and lower beak. The possible phenotypic plasticity of body and beak was also discussed in different aspects. Body size showed different variations among different climatic years. The size at the maturity stage in 2015 (El Niño year) was much smaller than that in other years for both sexes. The centroid size representing the beak size showed the significant difference between two types of Pacific Decadal Oscillation phases. The shapes of upper and lower beaks showed significant differences between small-scale climatic patterns in which El Niño or La Niña event occurred, displaying different growth patterns.

Construction of a new plant expression vector and the development of maize germplasm expressing the Aspergillus ficuum phytase gene PhyA2 - Peng Jiao; Wen-Ya Yuan; Han-Dan Zhao; Jing Qu; Pi-Wu Wang; Shu-Yan Guan; Yi-Yong Ma (Genetic Resources and Crop Evolution, 2021)
Phytases, which belong to a special category of orthophosphoric monoester phosphohydrolases, degrade inositol hexaphosphate to produce lower-grade inositol phosphate derivatives and inorganic phosphate. Thus, phytases may improve phosphorus utilization, eliminate the anti-nutrient properties of phytic acid, and mitigate environmental pollution due to phosphorus contamination. In this study, we constructed a new root-specific expression vector by inserting the Aspergillus ficuum phytase gene PhyA2 into pCAMBIA3301-ZmGLU1P-Nos. The subsequent molecular analysis confirmed that six T 4 generation transgenic plants carried and expressed PhyA2 . A quantitative real-time PCR analysis indicated PhyA2 was highly expressed in the transgenic roots. Additionally, the phytase activity was 10.9-fold higher in the transgenic roots (peak activity of 5.432 U/g) than in the control roots. Moreover, compared with the control rhizosphere, the organic phosphorus content in the rhizosphere of the transgenic plants decreased significantly (by up to 5.21 mg/kg). An agronomic trait analysis indicated that PhyA2 expression can increase maize seed weight by up to 25.8 g. Therefore, the integration of PhyA2 into the maize genome can enhance the ability of maize plants to use the phosphorus compounds in soil, while also improving the plant growth status and increasing the seed yield.

Effects of Dietary Zinc-Methionine Supplementation During Pregnancy on the Whole-Genome Methylation and Related Gene Expression in the Liver and Spleen of Growing Goats: a Short Communication - Qiushuang Li; Qiongxian Yan; Chuanshe Zhou; Shaoxun Tang; Xuefeng Han; Zhiliang Tan (Biological Trace Element Research, 2021)

Mechanisms of niche‐neutrality balancing can drive the assembling of microbial community - Lixiao Wang; Maozhen Han; Xi Li; Bingbing Yu; Huading Wang; Amjed Ginawi; Kang Ning; Yunjun Yan (Molecular Ecology, 2021)
One hotspot of present community ecology is to uncover the mechanisms of community succession. In this study, two popular concepts, niche‐neutrality dynamic balancing and co‐occurrence network analysis, were integrated to investigate the dispersal dynamics of microbial communities in a freshwater river continuum in subtropical China. Results showed that when habitat conditions were mild and appropriate, such as in the clean upstream river, free of heavy pollution or long‐lasting extreme disturbances, stochastic processes could increase species diversities, and organize communities into relatively loosely linked and stable networks with higher modularity and more modules. However, when conditions became degraded under heavy pollution, the influence of neutrality diminished, and niche‐based selection imposed more constraints on communities and guided the assembling processes in certain directions: depleting species richness, strengthening interspecies connections and breaking boundaries of modules. Consequently, communities became more sensitive to fluctuations so as to deal with the harsh conditions efficiently. Another interesting finding was that, both as keystone taxa of communities, module hubs were mostly neutrally distributed generalists with high abundances, and were beneficial to many related operational taxonomic units. In contrast, connectors were less abundant and their distributions were more subjected to the environments. Therefore, connectors were probably responsible for the information transmission between microbial communities and environments, as well as between different modules, and thus could restrict the dispersal of microbes and guide the direction of community assembly.

TAK1 is involved in sodium L-lactate-stimulated p38 signaling and promotes apoptosis - Qingen Da; Zilong Yan; Zhangfu Li; Zhen Han; Mingming Ren; Lei Huang; Xiaowei Zhang; Jikui Liu; Tao Wang (Molecular and Cellular Biochemistry, 2021)

The reduction of lipid-sourced energy production caused by ATGL inhibition cannot be compensated by activation of HSL, autophagy, and utilization of other nutrients in fish - Si-Lan Han; Yan Liu; Samwel M. Limbu; Li-Qiao Chen; Mei-Ling Zhang; Zhen-Yu Du (Fish Physiology and Biochemistry, 2021)

Association between selected urinary heavy metals and asthma in adults: a retrospective cross-sectional study of the US National Health and Nutrition Examination Survey - Xiuzhu Li; Yun Fan; Yan Zhang; Xiaomin Huang; Zhenyao Huang; Mingming Yu; Qiaoqiao Xu; Xiumei Han; Chuncheng Lu; Xinru Wang (Environmental Science and Pollution Research, 2021)

Cerebral blood flow alterations in hemodialysis patients with and without restless legs syndrome: an arterial spin labeling study - Hao Wang; Xue Han; Mei Jin; Li-yan Wang; Zong-li Diao; Wang Guo; Peng Zhang; Zheng Wang; Han Lv; He-yu Ding; Zheng-yu Zhang; Peng-fei Zhao; et al. (Brain Imaging and Behavior, 2021)

Sex-specific effects of cigarette smoking on caudate and amygdala volume and resting-state functional connectivity - Fuchun Lin; Xu Han; Yao Wang; Weina Ding; Yawen Sun; Yan Zhou; Hao Lei (Brain Imaging and Behavior, 2021)

Quantitatively determine the dominant driving factors of the spatial—temporal changes of vegetation NPP in the Hengduan Mountain area during 2000–2015 - Shu-ting Chen; Bing Guo; Rui Zhang; Wen-qian Zang; Cui-xia Wei; Hong-wei Wu; Xiao Yang; Xiao-yan Zhen; Xing Li; Da-fu Zhang; Bao-min Han; Hai-ling Zhang (Journal of Mountain Science, 2021)

Geological, Fluid Inclusion, H-O-S-Pb Isotope Constraints on the Genesis of the Erdaogou Gold Deposit, Liaoning Province - Fan Yang; Xuejiao Pang; Bin Li; Jingsheng Chen; Jilong Han; Miao Liu; Zhongzhu Yang; Yan Wang; Yi Shi (Journal of Earth Science, 2021)

Reduced magnitude and shifted seasonality of CO 2 sink by experimental warming in a coastal wetland - Baoyu Sun; Liming Yan; Ming Jiang; Xinge Li; Guangxuan Han; Jianyang Xia (Ecology, 2021)
Coastal wetlands have the highest carbon sequestration rate per unit area among all unmanaged natural ecosystems. However, how the magnitude and seasonality of the CO 2 sink in coastal wetlands will respond to future climate warming remains unclear. Here, based on measurements of ecosystem CO 2 fluxes in a field experiment in the Yellow River Delta, we found that experimental warming (i.e., a 2.4°C increase in soil temperature) reduced net ecosystem productivity (NEP) by 23.7% across two growing seasons of 2017–2018. Such a reduction in NEP resulted from the greater decrease in gross primary productivity (GPP) than ecosystem respiration (ER) under warming. The negative warming effect on NEP mainly occurred in summer (−43.9%) but not in autumn (+61.3%), leading to a shifted NEP seasonality under warming. Further analyses showed that the warming effects on ecosystem CO 2 exchange were mainly controlled by soil salinity and its corresponding impacts on species composition. For example, warming increased soil salinity (+35.0%), reduced total aboveground biomass (−9.9%), and benefited the growth of plant species with high salt tolerance and late peak growth. To the best of our knowledge, this study provides the first experimental evidence on the reduced magnitude and shifted seasonality of CO 2 exchange under climate warming in coastal wetlands. These findings underscore the high vulnerability of wetland CO 2 sink in coastal regions under future climate change.

Modes of genetic adaptations underlying functional innovations in the rumen - Xiangyu Pan; Yudong Cai; Zongjun Li; Xianqing Chen; Rasmus Heller; Nini Wang; Yu Wang; Chen Zhao; Yong Wang; Han Xu; Songhai Li; Ming Li; et al. (Science China Life Sciences, 2021)

Enteromorpha prolifera Diet Drives Intestinal Microbiome Composition in Siganus oramin - Yan Xu; Jin Li; Xuefeng Han; Zhibiao Zhang; Mingqi Zhong; Zhong Hu (Current Microbiology, 2021)

Speciation Analysis of Chromium in Chromium-Enriched Yeast by Ion Chromatography-Inductively Coupled Plasma Mass Spectrometry - Shuang-Qing Zhang; Sui-Han Cheng; Shi Shen; Bi-Ying Luo; Yan Zhang (Biological Trace Element Research, 2021)

Complete genome sequence of a new achyranthes virus A isolate from Achyranthes bidentata in China - Xinyang Wu; Yuchao Lai; Lanqing Lv; Kelei Han; Ziqiang Chen; Yuwen Lu; Jiejun Peng; Lin Lin; Jianping Chen; Hongying Zheng; Fei Yan (Archives of Virology, 2021)

A new cyclic peptide from the fibrous root of Pseudostellaria heterophylla - Xiao-fei Zhao; Qian Zhang; Han-tao Zhao; Yan-da Zhang; Han-ru Liu; Lu-jiang Yuan; Qian-feng Chen (Natural Product Research, 2020)

Dynamic Variations in Brain Glycogen are Involved in Modulating Isoflurane Anesthesia in Mice - Ze Fan; Zhihao Zhang; Shiyi Zhao; Yuanyuan Zhu; Dong Guo; Bo Yang; Lixia Zhuo; Jiao Han; Rui Wang; Zongping Fang; Hailong Dong; Yan Li; et al. (Neuroscience Bulletin, 2020)
General anesthesia severely affects the metabolites in the brain. Glycogen, principally stored in astrocytes and providing the short-term delivery of substrates to neurons, has been implicated as an affected molecule. However, whether glycogen plays a pivotal role in modulating anesthesia–arousal remains unclear. Here, we demonstrated that isoflurane-anesthetized mice exhibited dynamic changes in the glycogen levels in various brain regions. Glycogen synthase (GS) and glycogen phosphorylase (GP), key enzymes of glycogen metabolism, showed increased activity after isoflurane exposure. Upon blocking glycogenolysis with 1,4-dideoxy-1,4-imino-D-arabinitol (DAB), a GP antagonist, we found a prolonged time of emergence from anesthesia and an enhanced δ frequency in the EEG (electroencephalogram). In addition, augmented expression of glycogenolysis genes in glycogen phosphorylase, brain (Pygb) knock-in (Pygb H11/H11 ) mice resulted in delayed induction of anesthesia, a shortened emergence time, and a lower ratio of EEG-δ. Our findings revealed a role of brain glycogen in regulating anesthesia–arousal, providing a potential target for modulating anesthesia.

Calcimicrobes in Cambrian microbialites (Shandong, North China) and comparison with experimentally produced biomineralization precipitates - Yanyang Zhao; Huaxiao Yan; Maurice E. Tucker; Mei Han; Hui Zhao; Guangzhou Mao; Chao Peng; Zuozhen Han (Carbonates and Evaporites, 2020)

Frequency-dependent changes in fractional amplitude of low-frequency oscillations in Alzheimer’s disease: a resting-state fMRI study - Liu Yang; Yan Yan; Yuxia Li; Xiaochen Hu; Jie Lu; Piu Chan; Tianyi Yan; Ying Han (Brain Imaging and Behavior, 2020)

Construction and immune protection evaluation of recombinant virus expressing Newcastle disease virus F protein by the largest intergenic region of fowlpox virus NX10 - Yan Zhao; Zongxi Han; Xiaocai Zhang; Xuemei Zhang; Junfeng Sun; Deying Ma; Shengwang Liu (Virus Genes, 2020)

Updating and identifying three novel variants of the CARD14 gene in Chinese Han patients with psoriasis - Yike Huang; Chenhui Zhang; Lu Tao; Jiaqing Zhou; Jie Zhu; Kexiang Yan; Ling Han; Qiong Huang; Jinxiu Shi; Zhenghua Zhang (Journal of Genetics, 2020)

SNP of AHSA2 gene in three cattle breeds using snapshot technology - Shu-Zhu Cheng; E. Guang-Xin; Cheng-Li Liu; Wang-Dui Basang; Yan-Bin Zhu; Ri-Su Na; Yan-Guo Han; Yan Zeng; Xiao Wang; Wei-Wei Ni; Bai-Gao Yang; Xing-Hai Duan; et al. (Journal of Genetics, 2020)

Identification of hybrid green peafowl using mitochondrial and nuclear markers - Han Yu Du; Xin Yuan Zhang; Thi Dao Dinh; Yue Ma; Cheng Zong; Guang Long Li; Thomas D. Dahmer; Yan Chun Xu (Conservation Genetics Resources, 2020)

Light grazing facilitates carbon accumulation in subsoil in Chinese grasslands: A meta‐analysis - Zhi‐Yun Jiang; Zhong‐Min Hu; Derrick Y. F. Lai; Dao‐Rui Han; Mei Wang; Min Liu; Meng Zhang; Ming‐Yan Guo (Global Change Biology, 2020)
Grazing by livestock greatly affects the soil carbon (C) cycle in grassland ecosystems. However, the effects of grazing at different intensities and durations on the dynamics of soil C in its subsoil layers are not clearly understood. Here, we compiled data from 78 sites (in total 122 published studies) to examine the effects of varying grazing intensities and durations on soil C content at different depths for grasslands in China. Our meta‐analysis revealed that grazing led to an overall decrease in soil C content and productivity of above‐ground vegetation (e.g., above‐ground biomass and litter) but an increase in below‐ground biomass. Specifically, the effects of grazing on soil C content became less negative or even positive with increasing soil depths. An increase of soil C content was consequently found under light grazing (LG), although soil C content still decreased under moderate and heavy grazing. The increase in soil C content under LG could be largely attributed to the increase of soil C content in subsoil layers (>20 cm), despite that soil C content in surface soil layer (0–20 cm) decreased. Moreover, the magnitude of increase in soil C content under LG in subsoil layers increased with grazing duration. A possible reason of the increase in soil C content in the subsoil layers was due to the increases in below‐ground biomass. Our study highlights that LG may modify the allocation of C input and promote its accumulation in subsoil layers, thus offsetting the negative impact of grazing on surface soil C content, a finding that has significant implications for C sequestration in grasslands.