First report of plum bark necrosis stem pitting-associated virus affecting sweet cherry in Yunnan, China - Miao Guo; Jing Zhong; Chaowen Wang; Yue Chen; Zhengsong Yang; Tingting Li; Yongbin Wu; Yongqing Mu; Ming Ding; Jiawei He (Journal of Plant Pathology, 2022)

A Significant Fluorescent Aptamer Sensor Based on Carbon Dots and Graphene Oxide for Highly Selective Detection of Progesterone - Hanyue Cui; Huan Lu; Jing Yang; Yao Fu; Yan Huang; Li Li; Yaping Ding (Journal of Fluorescence, 2022)

The genes for sensory perception of sound should be considered in gene diagnosis of congenital sensorineural hearing loss and microtia - Ken Lin; Ding-Yun You; Li-Huan Zhang; Li-Juan Zhou; Jin-Yan Zu; Yang Xiao; Mei-Hua Sun; Dong-Su; Xue Cao; Tie-Song Zhang; Jing Ma (Journal of Applied Genetics, 2022)

Dexmedetomidine post-conditioning alleviates myocardial ischemia–reperfusion injury in rats by ferroptosis inhibition via SLC7A11/GPX4 axis activation - Peng Yu; Jing Zhang; Yi Ding; Dandan Chen; Haijian Sun; Fenglai Yuan; Siyuan Li; Xiaozhong Li; Pingping Yang; Linghua Fu; Shuchun Yu; Jiru Zhang (Human Cell, 2022)

Carbon emission intensity and biased technical change in China’s different regions: a novel multidimensional decomposition approach - Lili Ding; Kaixuan Zhang; Ying Yang (Environmental Science and Pollution Research, 2022)

Evaluation and structural analysis of the functions of the Tibetan Plateau National Park Cluster - Dongjun Chen; Linsheng Zhong; Jie Fan; Hu Yu; Ding Yang; Yuxi Zeng (Journal of Geographical Sciences, 2022)

Detailed amount of particle breakage in multi-sized coral sands under impact loading - Yu Peng; Xuanming Ding; Yang Xiao; Xin Deng; Weiting Deng (European Journal of Environmental and Civil Engineering, 2022)

Experimental Investigation of Wave-Induced Forces on a Large Quasi-Elliptical Cylinder during Extreme Events - Zhiying Yang; Hao Ding; Ke Li; Liang Cheng; Bo Huang; Qingyang Ren (Journal of Marine Science and Engineering, 2022)
Large quasi-elliptical cylinders are extensively used in ocean engineering. To enhance a better understanding of the hydrodynamic wave force on such quasi-elliptical cylinders during extreme events, a series of experiments on extreme wave interaction with a quasi-elliptical cylinder were conducted. A series of waves with various wave heights, wave periods, and wave incident directions were tested to investigate the wave parameter effect and wave directionality effect on the wave forces on the quasi-elliptical structure. The experimental results indicate that the extreme wave-induced forces on the quasi-elliptical cylinder are strongly correlated to the wave period and wave incident direction. The peak forces on the quasi-elliptical model do not vary monotonically with the increasing wave period but show an increase followed by a decrease. Both the longitudinal and transversal forces are significantly increased when the wave incident direction changes from 0° to 45° and the wave directionality effect is enhanced when the wave period is decreased. Additionally, the inertial force equation was applied to the wave force estimation for such quasi-elliptical cylinders, and the inertia coefficient CM was fitted based on the experimental results of α = 0°.

Viscoelastic-plastic constitutive model with non-constant parameters for brittle rock under high stress conditions - Shuling Huang; Chuanqing Zhang; Xiuli Ding; Liu Yang (European Journal of Environmental and Civil Engineering, 2022)

Localization of QTL for cold tolerance at the germination stage of rice (Oryza sativa L.) using recombinant inbred lines - Liangzi Cao; Shukun Jiang; Guohua Ding; Tongtong Wang; Liangming Bai; Jinsong Zhou; Yu Luo; Tianshu Xia; Hui Jiang; Kai Liu; Xueyang Wang; Guang Yang; et al. (Genetic Resources and Crop Evolution, 2022)
The cold tolerance of germinating direct-sown rice ( Oryza sativa L.) has an increased rate of emergence, which ensures vigorous seedling growth. Research on QTL localization for cold tolerance at the germination stage can assist in molecular marker-assisted selection and enhance breeding efficiency. In this study, 94 populations of recombinant self-incompatible lines from Heigu and Ha 9366 were selected to investigate germination rates at low temperatures. It was found that two QTL loci (qLTG-3 and qLTG-12) were located at different germination times on chromosomes 3 and 12, respectively. The two QTLs at three different germination times, located using QTL, accounted for 21.3–25.9% of the phenotypic variation. Moreover, a reciprocal effect was detected between the two QTLs. The double QTLs increased the germination rate by 22–27% in this population. Additionally, qLTG-12 improved cold tolerance at the seedling stage. The results of this study might provide the materials and molecular markers for future molecular marker-assisted breeding for cold tolerance at the germination stage.

Indoor air pollution from solid fuel on children pneumonia in low- and middle-income countries: a systematic review and meta-analysis - Tianming Chen; Chao Zou; Yang Yuan; Jingjing Pan; Baoping Zhang; Liang Qiao; Yanping Li; Jia-yan Qian; Qingyuan Guo; Ye Yuan; Cheng Ding (Environmental Science and Pollution Research, 2022)

Short-term effect of ambient air pollutant change on the risk of tuberculosis outpatient visits: a time-series study in Fuyang, China - Xin-Qiang Wang; Ying-Qing Li; Cheng-Yang Hu; Kai Huang; Kun Ding; Xiao-Jing Yang; Xin Cheng; Kang-Di Zhang; Wen-Jie Yu; Jie Wang; Yong-Zhong Zhang; Zhen-tao Ding; et al. (Environmental Science and Pollution Research, 2022)

The Value of China’s Legislation on Plastic Pollution Prevention in 2020 - Jianli Liu; Yunfei Yang; Lihui An; Qiang Liu; Jiannan Ding (Bulletin of Environmental Contamination and Toxicology, 2022)

The selective contributions of right cerebellar lobules to reading - Hehui Li; Rebecca A. Marks; Lanfang Liu; Xiaoxia Feng; Manli Zhang; Feng Ai; Yue Gao; Mengyu Tian; Xiujie Yang; Jia Zhang; Hejing Zhong; Li Liu; et al. (Brain Structure and Function, 2022)

Vegetation-related dry deposition of global PM2.5 from satellite observations - Huihui Feng; Ying Ding; Bin Zou; Jason Blake Cohen; Shuchao Ye; Zhuolin Yang; Kai Qin; Lei Liu; Xiaodong Gu (Journal of Geographical Sciences, 2022)

The chronological and geochemical characteristics of Triassic gabbro diorite in the Hongshuihe area of the East Kunlun Orogenic Belt, Northwest China - Xuan Zhou; Qing-feng Ding; Rui-zhe Wu; Yang Gao (Arabian Journal of Geosciences, 2022)

The rainfall thresholds and soil characteristics of large geological disasters in Zhejiang, China - Jin Ding; Guoping Zhang; Jinbing Gao; Shudong Wang; Bing Xue; Kuoyin Wang; Jing Yang; Ruijiao Jiang; Junbiao Lian (Arabian Journal of Geosciences, 2022)
Based on observed minute precipitation data during Lekima influencing Zhejiang (from 2019–08-07 00:00:00 to 2019–08-12 23:55:00), the rainfall thresholds for debris flow and landslide are investigated. The rainfall intensity and duration (I-D) thresholds are I = 1247.73D −403.44 + 19.09 and I = 142.63D −0.58 –3.37 for debris flow and landslide, respectively. Hourly meteorological data and soil data reveal that (1) the soil volume water content (SVWC) at deep soil layers (50–100 cm) fluctuated continuously during the occurrence of debris flow and landslide. At the end of the landslide period, SVWC at deep soil layers returned stable. (2) At the same soil layer, there was little difference between the upper adjacent values of SVWC in the periods of debris flow and landslide, but the lower adjacent values in the period of landslide were smaller. However, different from the distribution of soil moisture, the lower adjacent values of the soil temperature at all layers were basically the same when debris flow and landslide occurred, while the upper adjacent values were higher when landslide occurred than when debris flow occurred. (3) Compared with the whole typhoon influencing period and debris flow occurrence period, ground surface temperature and surface air temperature, soil temperature, and surface air temperature showed better correlations in landslide occurrence period. (4) Both during debris flow and landslide occurrence time, the soil temperature at all layers did not change with the change of soil depth. Soil temperature and moisture at shallow soil layers owned better correlations than at deep soil layers.

MOG antibody-associated disease presenting with tumefactive lesions and closed-ring enhancement - Yin-Xi Zhang; Yang Zheng; Meng-Ting Cai; Qiang Du; Mei-Ping Ding (Acta Neurologica Belgica, 2022)

Future changes in the meteorological potential for winter haze over Beijing during periods of peak carbon emissions and carbon neutrality in China projected by Coupled Model Intercomparison Project Phase 6 models - Jing Wang; Yanju Liu; Yihui Ding; Yang Yang; Ying Xu; Qiaoping Li; Yingxian Zhang; Meng Gao; Jianbo Yang; Qingyuan Wu; Chunhui Li; Mingcai Li (International Journal of Climatology, 2022)
Hazy conditions have a significant impact on the environment and societal development. Their occurrence and persistence depend largely on climatological conditions, including the important role of climate change. Based on monthly data from 15 Coupled Model Intercomparison Project Phase 6 (CMIP6) models under three Tier 1 scenarios (SSP1–2.6, SSP2–4.5, and SSP5–8.5), the meteorological potential for winter haze pollution over Beijing was assessed during periods of peak carbon emissions (P CP ; 2021–2030) and carbon neutrality (approximate net‐zero emissions) (P CN ; 2051–2060) in China. The results show that a possible high‐emission strategy during P CP may not obviously enhance winter hazy conditions over Beijing in the near future. Rather, the high‐emission scenario in this period may decrease the meteorological potential that is favourable for the enhanced Beijing haze pollution by inducing a Northeast Asia cyclonic anomaly, compared to situations under SSP2–4.5, with medium emissions. Further analyses indicated that, under the continued sustainable pathway (SSP1–2.6 in P CN plus SSP1–2.6 in P CP ; the better pathway simulating the effects of approximate net‐zero emissions during P CN through model results), atmospheric conditions such as the East Asian winter monsoon as well as decadal oceanic forcings of the mega‐El Niño and the warm Atlantic Multidecadal Oscillation, which are conducive to more frequent Beijing haze, are significantly suppressed in the farther future P CN . Under such circumstances, in situ haze pollution is highly repressed, suggesting a critical and positive role for the low‐carbon policy advocated by China during P CN in suppressing longer‐term hazy conditions over Beijing. In contrast, Beijing haze pollution during P CN is frequent under the discontinued sustainable pathway (SSP2–4.5/SSP5–8.5 in P CN plus SSP1–2.6 in P CP ). Our findings demonstrate the possible insignificant impact of the high‐emission strategy of China during the near‐future P CP on Beijing haze exacerbation, and an important role for carbon neutrality advocated by China to suppress the haze potential in the farther future P CN , highlighting the significance of future pathway selections.

Impact of Wave–Current Interactions on the Detachment of Low-Salinity Water From Changjiang River Plume and Its Subsequent Evolution - Zhipeng Jiang; Dehai Song; Qinsheng Wei; Yang Ding (Frontiers in Marine Science, 2022)
The evolution of low-salinity water (LSW) detached from river plumes is critical to coastal systems and inner-shelf biogeochemical processes. In this study, the impact of wave–current interactions on the LSW detachment from the Changjiang River plume and its subsequent evolution is explored. Waves can advance the detachment of LSW through enhancing the vertical mixing, the northward intrusion of the inshore branch of the Taiwan Warm Current, and the upwelling. The wave-enhanced vertical mixing increases the core salinity of the initially isolated LSW and the growth rate of the core salinity during its subsequent evolution. Waves can lengthen the journey of the isolated LSW and accelerate its movement. Five wave–current interaction processes are compared and it is found that the wave-induced form drag contributes the most to the LSW detachment and its subsequent evolution. It enhances the vertical mixing and alters the wave-driven flow through the vertical transfer of wave-generated pressure to the momentum equation and the turbulent kinetic energy (TKE) equations. The wave dissipation working in the TKE equations weakens the northeastward flow off the Changjiang River estuary, which restrains the diluted water expansion. The current advection and refraction of wave energy contribute most to the enhancement of the double-core upwelling system.

Influences of the 1855 AD Huanghe (Yellow River) Relocation on Sedimentary Organic Carbon Burial in the Southern Yellow Sea - Jianying Liu; Da-Wei Li; Yang Ding; Tiantian Ge; Weifang Chen; Chih-An Huh; Meixun Zhao (Frontiers in Marine Science, 2022)
The Huanghe (Yellow River) supplies large amount of sediments and terrestrial organic carbon (OC) to the eastern Chinese marginal seas. A relocation of the Huanghe outlet from the southern Yellow Sea (YS) to the Bohai Sea occurred in 1855 AD, however, detailed knowledge about the impact of this relocation on sedimentary source and OC burial in Chinese marginal seas is still critically lacking. In this study, we present total OC content and its isotope (δ 13 C), along with bulk total organic carbon (TOC)/total nitrogen (TN) molar ratio and lipid biomarker contents, in a sediment core HH12 from the southern YS with sediment age spanning the last 300 years. We find that TOC and terrestrial lipid biomarker mass accumulation rates were lower between 1855 AD and 1950 AD than that prior to 1855 AD in core HH12; and in accordance, both TOC/TN ratio and δ 13 C records indicate a gradual decrease of terrigenous source contributions to sedimentary OC. This suggests that the relocation of the Huanghe outlet reduced the transport of terrestrial OC to the southern YS. However, the δ 13 C record also indicates a relative increase of terrestrial OC contribution to sedimentary OC after 1950 AD, and the most likely explanation is increased contributions from the old Huanghe delta erosion and Korean rivers. Future studies should focus on better constraining the variations of terrestrial and marine endmembers with δ 13 C and Δ 14 C analyses of specific biomarkers to examine these linkages.

Sorption of pharmaceuticals and personal care products (PPCPs) from water and wastewater by carbonaceous materials: A review - Ming Zhang; Jialing Shen; Yuchi Zhong; Tao Ding; Pavani Dulanja Dissanayake; Yi Yang; Yiu Fai Tsang; Yong Sik Ok (Critical Reviews in Environmental Science and Technology, 2022)

Polysaccharide Krestin Prevents Alzheimer’s Disease-type Pathology and Cognitive Deficits by Enhancing Monocyte Amyloid-β Processing - Si-Han Chen; Chen-Yang He; Ying-Ying Shen; Gui-Hua Zeng; Ding-Yuan Tian; Yuan Cheng; Man-Yu Xu; Dong-Yu Fan; Cheng-Rong Tan; An-Yu Shi; Xian-Le Bu; Yan-Jiang Wang (Neuroscience Bulletin, 2022)

Genetic variation of pharmacogenomic VIP variants in the Chinese Li population: an updated research - Shuangyu Yang; Xia Dou; Zhen Wang; Wenjie Zhang; Kefan Ding; Wenting Meng; Haiyue Li; Jianfeng Liu; Yuanwei Liu; Tianbo Jin (Molecular Genetics and Genomics, 2022)

Two new species of Tricholoma sect. Genuina (Agaricales) from China based on molecular phylogenetic and morphological evidence - Xiao-Xia Ding; Yang-Yang Cui; Zhu L. Yang (Mycological Progress, 2022)

Tricholoma sect. Tricholoma (Tricholomataceae) from China: molecular phylogeny and taxonomy - Yang-Yang Cui; Xiao-Xia Ding; G. Kost; Zhu L. Yang (Mycological Progress, 2022)

Replacing fishmeal with soybean meal affects survival, antioxidant capacity, intestinal microbiota, and mRNA expression of TOR and S6K1 in Macrobrachium rosenbergii - Zhili Ding; Dongsheng Zhou; Jinxian Zheng; Xuefeng Chen; Youqin Kong; Changle Qi; Yan Liu; Qiongying Tang; Guoliang Yang; Jinyun Ye (Journal of Oceanology and Limnology, 2022)

Facile Synthesis of Carbon Dots from Biomass Material and Multi-Purpose Applications - Lina Xu; Na Yao; Haiyang Ding; Xiaohua Yang; Shouhai Li; Jianling Xia; Mei Li (Journal of Fluorescence, 2022)

Simulating the Effects of Conventional Tillage Versus No-Tillage on Nitrogen Uptake and Utilization of Winter Wheat with RZWQM2 in a 7-year Field Experiment - Jinli Ding; Sen Li; Wei Hu; Jicheng Wu; Yonghui Yang (International Journal of Plant Production, 2022)

Blockade of ASIC1a inhibits acid-induced rat articular chondrocyte senescence through regulation of autophagy - Yang Yang; Jie Ding; Yong Chen; Ganggang Ma; Xin Wei; Renpeng Zhou; Wei Hu (Human Cell, 2022)

The impact of technological progress on China’s haze pollution—based on decomposition and rebound research - Huihui Xia; Lei Ding; Shuwang Yang (Environmental Science and Pollution Research, 2022)

Katabatic Flow Structures Indicative of the Flux Dissimilarity for Stable Stratification - Xiaofeng Guo; Wei Yang; Zhiqiu Gao; Linlin Wang; Jinkyu Hong; Baohong Ding; Long Zhao; Degang Zhou; Kun Yang (Boundary-Layer Meteorology, 2022)

Magnetotelluric responses of a vertical inhomogeneous and anisotropic resistivity structure with a transitional layer - Linjiang Qin; Changfu Yang; Weifeng Ding (Acta Geodaetica et Geophysica, 2022)

Sweet tea ( Lithocarpus polystachyus rehd.) as a new natural source of bioactive dihydrochalcones with multiple health benefits - Ao Shang; Hong-Yan Liu; Min Luo; Yu Xia; Xiao Yang; Hang-Yu Li; Ding-Tao Wu; Quancai Sun; Fang Geng; Ren-You Gan (Critical Reviews in Food Science and Nutrition, 2022)

NPC1-regulated dynamic of clathrin-coated pits is essential for viral entry - Guoli Li; Bingqian Su; Pengfei Fu; Yilin Bai; Guangxu Ding; Dahua Li; Jiang Wang; Guoyu Yang; Beibei Chu (Science China Life Sciences, 2022)

Transformation of fertilizer nitrogen in fluvo-aquic soils with different textures and its influencing factors - Shijie Ding; Xiuli Xin; Wenliang Yang; Xianfeng Zhang; Anning Zhu; Shaomin Huang; Jiao Yang; Guocui Ren; Mengrou Li (Plant and Soil, 2022)

Immunodominant membrane protein (Imp) promotes the transmission of wheat blue dwarf (WBD) phytoplasma by directly interacting with α-tubulin in leafhoppers - Lei Ding; Wenjing Lu; Yanjun Yang; Qinrong Zhong; Tong Zhou; Guiling Wang; Chengyan Song; Wendong Ma; Wei Chen; Yunfeng Wu (European Journal of Plant Pathology, 2022)

Identification of candidate genes for panicle length in Oryza sativa L. ssp. japonica via genome-wide association study and linkage mapping - Hongliang Zheng; Shichen Sun; Liangming Bai; Shukun Jiang; Guohua Ding; Tongtong Wang; Hongwei Zhao; Jingguo Wang; Hualong Liu; Luomiao Yang; Yan Jia; Xin Wei; et al. (Euphytica, 2022)

MiR-582-3p participates in the regulation of biological behaviors of A549 cells by ambient PM2.5 exposure - Mei Yang; Liangliang Ju; Changlian Li; Han Cheng; Na Li; Qi Zhang; Shu Sun; Liu Ding; Xinmiao Sui; Chao Zhang; Mingwei Yang; Jiyu Cao; et al. (Environmental Science and Pollution Research, 2022)

Fixed-bed column dynamics of ultrasound and Na-functionalized diatomite to remove phosphate from water - Junxiu Ye; Min Yang; Xuemei Ding; Wei Tan; Guizhen Li; Shuju Fang; Hongbin Wang (Environmental Science and Pollution Research, 2022)

Numerical investigation of the control factors driving Zhe-Min Coastal Current - Yang Zhang; Fei Chai; Joseph Zhang; Yang Ding; Min Bao; Yunwei Yan; Hong Li; Wei Yu; Liang Chang (Acta Oceanologica Sinica, 2022)

Identification and Characterization of Immunoglobulin T Heavy Chain in Large Yellow Croaker (Larimichthys crocea) - Yan Teng; Qiuling Fu; Yuanzhen Tan; Yangyang Ding; Yang Ding; Xinhua Chen (Fishes, 2022)
Three immunoglobulin (Ig) isotypes have been identified in teleosts, IgM, IgD, and IgT or IgZ. IgT, a new teleost Ig isotype, plays a vital role in mucosal immunity. However, information on molecular and functional characteristics of fish IgT is still limited. In this study, an IgT heavy chain (LcIgT) gene was cloned and characterized in large yellow croaker (Larimichthys crocea). Complete cDNA of LcIgT was 1930 bp in length, encoding a protein of 554 amino acids. The deduced LcIgT contains a VH region and only three CH regions (CH1, CH2, CH4), but no transmembrane region was predicted. Phylogenetic analysis showed that IgT heavy chain sequences from all fish species are grouped together. Homology comparison showed that LcIgT shares the highest amino acid identity of 58.73% with IgT heavy chain in Scophthalmus maximus. The VH domain of LcIgT has the highest identity of 72.50% with that of Scophthalmus maximus IgT. Relatively, each constant domain of LcIgT exhibits the highest amino acid identity with that of IgT in Oreochromis niloticus (67.61% identity for CH1, 61.11% identity for CH2, and 63.74% identity for CH4). LcIgT was constitutively expressed in various tissues tested, with the highest levels in mucosa-associated tissues such as gills and skin. After Cryptocaryon irritans infection, the mRNA levels of LcIgT were significantly up-regulated in the spleen (3.27-fold) at 4 d, in the head kidney (3.98-fold) and skin (2.11-fold) at 7 d, and in gills (4.45-fold) at 14 d. The protein levels in these detected tissues were all significantly up-regulated; the peak of its up-regulation was 6.33-fold at 28d in gills, 3.44-fold at 7d in skin, and 3.72-fold at 14d in spleen. These results showed that IgT response could be simultaneously induced in both systemic and mucosal tissues after parasitic infection and that IgT may be involved in systemic immunity and mucosal immunity against parasitic infection.

The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives - Arakkaveettil Kabeer Farha; Ren-You Gan; Hua-Bin Li; Ding-Tao Wu; Atanas G. Atanasov; Khalid Gul; Jia-Rong Zhang; Qiong-Qiong Yang; Harold Corke (Critical Reviews in Food Science and Nutrition, 2022)

Prediction of the Influence of Runner Tip Clearance on the Performance of Tubular Turbine - Yanzhao Wu; Xiaohang Wang; Xiaolong Yang; Junfeng Ding; Di Zhu; Ran Tao; Huanmao Wang; Ruofu Xiao (Journal of Marine Science and Engineering, 2022)
Tubular turbine is a type of turbine with low-head. Due to the fact that the runner of a tubular turbine is of axial-flow type, there will be a certain width of blade tip between the blade and the chamber. In order to explore the influence of tip clearance width on the flow inside the turbine, taking the model tubular turbine as the research object, six different tip clearance widths were compared and analyzed. The research shows that the increase in blade tip clearance width affects the performance of the turbine, reduces the minimum pressure at blade tip and causes cavitation in advance. Larger tip clearance width significantly increases pressure pulsation intensity inside the turbine, especially in the vaneless region between the runner and guide vane and the area of the runner tip. However, the increase in tip clearance width can greatly reduce the axial force for about 100 N and radial excitation force for about 50% of rotating parts. Therefore, during the design and processing of tubular turbines, the blade tip clearance width should be carefully selected to ensure safe and stable operation of the unit.

Nanofiltration Membrane Fouling and Control Caused by Residual Aluminum in Feed Water - Hui-Bo Yu; Xian-Qiu Zhang; Xue Han; Zhen-Zhen Yang; Ya-Wen Zhou; Wen Ding; Ming-Xia Du (Water, Air, & Soil Pollution, 2022)

Rice functional genomics: decades’ efforts and roads ahead - Rongzhi Chen; Yiwen Deng; Yanglin Ding; Jingxin Guo; Jie Qiu; Bing Wang; Changsheng Wang; Yongyao Xie; Zhihua Zhang; Jiaxin Chen; Letian Chen; Chengcai Chu; et al. (Science China Life Sciences, 2022)

Identification of WRKY transcription factors responding to abiotic stresses in Brassica napus L. - Hao Chen; Yongfeng Wang; Jiong Liu; Tian Zhao; Cuiling Yang; Qunying Ding; Yanfeng Zhang; Jianxin Mu; DaoJie Wang (Planta, 2022)

A community effort to assess and improve computerized interpretation of 12-lead resting electrocardiogram - Zijian Ding; Guijin Wang; Huazhong Yang; Ping Zhang; Dapeng Fu; Zhen Yang; Xinkang Wang; Xia Wang; Zhourui Xia; Chiming Zhang; Wenjie Cai; Binhang Yuan; et al. (Medical & Biological Engineering & Computing, 2022)
Computerized interpretation of electrocardiogram plays an important role in daily cardiovascular healthcare. However, inaccurate interpretations lead to misdiagnoses and delay proper treatments. In this work, we built a high-quality Chinese 12-lead resting electrocardiogram dataset with 15,357 records, and called for a community effort to improve the performances of CIE through the China ECG AI Contest 2019. This dataset covers most types of ECG interpretations, including the normal type, 8 common abnormal types, and the other type which includes both uncommon abnormal and noise signals. Based on the Contest, we systematically assessed and analyzed a set of top-performing methods, most of which are deep neural networks, with both their commonalities and characteristics. This study establishes the benchmarks for computerized interpretation of 12-lead resting electrocardiogram and provides insights for the development of new methods.

Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity - Chiara Fallerini; Nicola Picchiotti; Margherita Baldassarri; Kristina Zguro; Sergio Daga; Francesca Fava; Elisa Benetti; Sara Amitrano; Mirella Bruttini; Maria Palmieri; Susanna Croci; Mirjam Lista; et al. (Human Genetics, 2022)
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management.

Prenatal air pollution exposure increases the risk of macrosomia: evidence from a prospective cohort study in the coastal area of China - Changlian Li; Liangliang Ju; Mei Yang; Qi Zhang; Shu Sun; Jiyu Cao; Rui Ding (Environmental Science and Pollution Research, 2022)

Quercetin improves the adipose inflammatory response and insulin signaling to reduce “real-world” particulate matter-induced insulin resistance - Jinjin Jiang; Guofu Zhang; Min Yu; Juan Gu; Yang Zheng; Jinxia Sun; Shibin Ding (Environmental Science and Pollution Research, 2022)

Microbial controls on heavy metals and nutrients simultaneous release in a seasonally stratified reservoir - Xuecheng Zhang; Shiyuan Ding; Hong Lv; Gaoyang Cui; Mengdi Yang; Yiyao Wang; Tianhao Guan; Xiao-Dong Li (Environmental Science and Pollution Research, 2022)

Measuring the environmental protection efficiency and productivity of the 49 largest iron and steel enterprises in China - Shijie Ding; Jing Zhao; Meng Zhang; Sheng Yang; Hongwei Zhang (Environment, Development and Sustainability, 2022)

Alcanivorax limicola sp. nov., isolated from a soda alkali-saline soil - Lin Zhu; Yuan Wang; Yiwei Ding; Kai Luo; Biyue Yang; Sai Yang; Shenkui Liu; Henglin Cui; Wei Wei (Archives of Microbiology, 2022)

Nakamurella leprariae sp. nov., isolated from a lichen sample - De-Feng An; Shao-Juan Yang; Long-Qian Jiang; Xin-Yu Wang; Xiao-Yu Huang; Lei Lang; Xue-Mei Chen; Ming-Qun Fan; Gui-Ding Li; Ming-Guo Jiang; Li-Song Wang; Cheng-Lin Jiang; et al. (Archives of Microbiology, 2022)

Comprehensive effects of salt stress and peanut cultivars on the rhizosphere bacterial community diversity of peanut - Yang Xu; Zhimeng Zhang; Hong Ding; Saiqun Wen; Guanchu Zhang; Feifei Qin; Liangxiang Dai (Archives of Microbiology, 2022)

Impacts of the seesaw mode between the Indian and East Asian summer monsoons on interannual variations in surface solar radiation across the low‐latitude highlands of China - Yuchao Ding; Ruowen Yang; Jie Cao (International Journal of Climatology, 2022)
The relationship between the seesaw mode that connects the Indian summer monsoon (ISM) and East Asian summer monsoon (EASM), and variations in summer surface solar radiation (SSR) across the low‐latitude highlands of China (CLLH), was investigated using atmospheric reanalysis and NOAA global gridded precipitation and outgoing longwave radiation datasets. Singular value decomposition, correlation analysis, and composite analysis were employed. The results indicate that the interannual variations in summer SSR in the CLLH are significantly modulated by the seesaw mode that connects the ISM with the EASM. During the boreal summer, the CLLH SSR variability is positively correlated with ISM intensity, but negatively correlated with EASM intensity. When a strong ISM and a weak EASM occur together, significant anomalous northeasterly winds appear over the CLLH, which reduces the moisture supply to the region from the Bay of Bengal. In addition, significant anomalous descending motion dominates the CLLH, leading to significant negative relative humidity anomalies over the CLLH. Consequently, water vapour, total liquid water form column clouds and high cloud cover decreased significantly over the CLLH, resulting in a higher CLLH SSR than average. Conversely, a lower‐than‐normal CLLH SSR seems to result from the approximately opposite physical process during the years where the ISM is weak and EASM is strong over the CLLH. Given the fact that the correlation between the aerosol optical depth (AOD) and the CLLH SSR is relatively weak, the AOD variability may not be the main control on interannual variations of summer CLLH SSR.

Species Composition and Assemblages of Ichthyoplankton in Sansha Bay, Fujian Province, China - Yan Jiang; Bai-an Lin; Hao-yang He; Guang-mao Ding; Li-ting Yan; Ge Zhang; Min Liu; Lian-ming Zheng (Frontiers in Marine Science, 2021)
Sansha Bay (26.40−27.00°N, 119.50−120.20°E) is a typical semi-enclosed bay, located in northern Fujian Province, China, and adjacent to the East China Sea. The ichthyoplankton species composition and assemblage structure were investigated based on monthly sampling at 25 stations in April−September 2019, covering the important spring and summer spawning seasons in the region. Sampling was conducted in the first 3−5 days of the full moon or new moon phases using a standard plankton net through horizontal and vertical tows during daytime. In total, 25,819 ichthyoplankton samples were collected, of which 25,449 samples (i.e., 24,757 eggs and 692 larvae) were from horizontal tows. For horizontal tow samples, the ichthyoplankton were classified into 58 taxa in 15 orders and 23 families with a combination of external morphology and DNA barcoding analyses, from pelagic to demersal and benthic species. The dominant order was the Gobiiformes, including 23 species (39.7% of all species). The dominant taxa, in terms of relative abundance and frequency of occurrence, consisted of commercially important fishes, such as Setipinna tenuifilis (Valenciennes, 1848) (Engraulidae), Epinephelus akaara (Temminck and Schlegel, 1842) (Serraenidae), Collichthys lucidus (Richardson, 1844), Nibea albiflora (Richardson, 1846) (Sciaenidae), Acanthopagrus schlegelii (Bleeker, 1854), and Pagrus major (Temminck and Schlegel, 1843) (Sparidae), accounting for 78.9% of the horizontal tow samples. Low-valued and small-sized fishes, such as Stolephorus commersonnii Lacepède, 1803 (Engraulidae), Solea ovata Richardson, 1846 (Soleidae), Nuchequula nuchalis (Temminck and Schlegel, 1845), and Photopectoralis bindus (Valenciennes, 1835) (Leiognathidae), were also dominant species, accounting for 11.4% of the horizontal tow samples. The ichthyoplankton assemblage was categorized into five different temporal assemblages based on the cluster and nonmetric multidimensional scaling analysis, namely, April, May, June, July, and August−September (ANOSIM, Global R = 0.656, p < 0.01) with the highest density and richness of ichthyoplankton occurred in May. The spatial distribution pattern showed that the high density (ind./m 3 ) of ichthyoplankton occurred mainly in S12–S25 in Guanjingyang and along the Dongchong Peninsula coastline into Dongwuyang, while low density occurred mainly in S01–S11 in the northwest waters of Sandu Island (ANOVA, F = 8.270, p < 0.05). Temperature, salinity, and chlorophyll a were key factors structuring the ichthyoplankton assemblages in Sansha Bay. In addition, this study revealed the changes of the ichthyoplankton composition, density, and spatial distribution in Sansha Bay over the past three decades.

Diversity and dynamics of microbial ecosystem on berry surface during the ripening of Ecolly (Vitis vinifera L.) grape in Wuhai, China - Yinting Ding; Ruteng Wei; Lin Wang; Chenlu Yang; Hua Li; Hua Wang (World Journal of Microbiology and Biotechnology, 2021)

Transcriptome analysis reveals MYB and WRKY transcription factors involved in banana (Musa paradisiaca AA) magnesium deficiency - Yong Yang; Xinping Li; Baolin Kan; Hongsu He; Ting Li; Yuanhao Ding; Pengmeng Du; Wenjie Lai; Haiyan Hu; Jiaquan Huang (Planta, 2021)

Analysis of the changes of electron transfer and heterogeneity of photosystem II in Deg1-reduced Arabidopsis plants - Xiaogang Wen; Zhipan Yang; Shunhua Ding; Huixia Yang; Lixin Zhang; Congming Lu; Qingtao Lu (Photosynthesis Research, 2021)

Life cycle greenhouse gas emissions of aluminum based on regional industrial transfer in China - Ning Ding; Ning Liu; Bin Lu; Jianxin Yang (Journal of Industrial Ecology, 2021)
Aluminum production is a major energy consumer and source of greenhouse gas (GHG) emissions. The regional transfer of the primary aluminum (PA) industry, which mainly consists of the processes of electrolysis and aluminum ingot casting, is currently an important international trend in aluminum industrial development. However, the changes in GHG emissions from aluminum production for such transfers are unclear. This study has established a life cycle assessment model of aluminum industry based on regional transfers in the context of China, determined the GHG emissions of PA and secondary aluminum (SA) production, examined the GHG emission changes of PA production based on regional industry transfer between the years 2007 and 2017, and explored seven driving factors that affect GHG emissions in the aluminum industry. GHG emissions per unit PA and SA production in China decreased by 18.6% and 6.3%, respectively, but the total GHG emissions from aluminum industry still increased by 2.2 times between the years 2007 and 2017. The driving factor analysis showed that the major positive effects of GHG emissions from China's aluminum industry from 2007 to 2017 included the production scale effect of SA and the energy structure effect. Existing regional transfers (between the years 2007 and 2017) did not deliver significant annual GHG emissions reductions. Currently, Xinjiang, Henan, Shandong, and Inner Mongolia are the main PA production provinces in China, although regional transfers have been implemented. This study provides a basis for the improvement and sustainable development of the aluminum industry, suggests policies for regional aluminum development, and proposes a beneficial layout of the aluminum industry.

Osteoarthritic infrapatellar fat pad aggravates cartilage degradation via activation of p38MAPK and ERK1/2 pathways - Zuoqing Zhou; Su’an Tang; Xiaoyu Nie; Yiqun Zhang; Delong Li; Yang Zhao; Yumei Cao; Jianwen Yin; Tianyu Chen; Guangfeng Ruan; Zhaohua Zhu; Xiaochun Bai; et al. (Inflammation Research, 2021)

Kcnk3, Ggta1, and Gpr84 are involved in hyperbaric oxygenation preconditioning protection on cerebral ischemia–reperfusion injury - Chunhui Yang; Minjun Ding; Guiqiang Shao; Shengjie Jia; Xue Yin; Yuhui Cui; Zetian Wang; Chunrong Wu (Experimental Brain Research, 2021)
The present study aimed to explore the potential mechanism of the effect of hyperbaric oxygenation (HBO) preconditioning on cerebral ischemia and reperfusion injury (CIRI). GSE23160 dataset was used to identify differentially expressed genes (DEGs) from striatum between the middle cerebral artery occlusion (MCAO)/reperfusion and sham rats. The gene clusters with continuous increase and decrease were identified by soft clustering analysis in Mfuzz, and functional enrichment analysis of these genes was performed using clusterProfiler package. The intersection set of the genes with significantly altered expression at post-reperfusion 2, 8, and 24 h were screened in comparison to 0 h (sham group), and the expression of these genes was detected in the MCAO/reperfusion model and HBO preconditioning groups by real-time PCR (RT-PCR) and western blotting. A total of 41 upregulated DEGs, and 7 downregulated DEGs were detected, among which the expression of Gpr84 and Ggta1 was significantly upregulated at each reperfusion phase as compared to the sham group, while the expression of Kcnk3 was significantly downregulated except in the postreperfusion 8 h in the striatum group. RT-PCR and western blotting analyses showed that the expression of Ggta1 , Gpr84 , and Kcnk3 genes between the MCAO/reperfusion and sham rats were consistent with the bioinformatics analysis. In addition, the HBO preconditioning reduced the expression of Ggta1 and Gpr84 and increased the expression of Kcnk3 in MCAO/reperfusion rats. Kcnk3 , Ggta1 , and Gpr84 may play a major role in HBO-mediated protection of the brain against CIRI.

External evaluation of published population pharmacokinetic models of polymyxin B - Ya-qian Li; Kai-feng Chen; Jun-jie Ding; Hong-yi Tan; Nan Yang; Ya-qi Lin; Cui-fang Wu; Yue-liang Xie; Guo-ping Yang; Jing-Jing Liu; Qi Pei (European Journal of Clinical Pharmacology, 2021)

Implications for emergency response to the severe odor incident occurred in source water: Potential odorants and control strategy - Qingyuan Guo; Zhaoxia Li; Tianming Chen; Bairen Yang; Cheng Ding (Environmental Science and Pollution Research, 2021)

Omi inhibition ameliorates neuron apoptosis and neurological deficit after subarachnoid hemorrhage in rats - Yuanfeng Du; Dingbo Yang; Xiaoqiao Dong; Quan Du; Ding Wang; Yongfeng Shen; Wenhua Yu (Genes & Genomics, 2021)
Background Subarachnoid hemorrhage (SAH) is a severe neurological emergency, resulting in cognitive impairments and threatening human's health. Currently, SAH has no effective treatment. It is urgent to search for an effective therapy for SAH. Objective To explore the expression of Omi protein after subarachnoid hemorrhage in rats. Methods SAH rat model was established by injecting blood into the prechiasmatic cistern. Neurological deficit was assessed by detecting neurological deficit scores and brain tissue water contents. Apoptotic cells were evaluated by TUNEL staining and IHC staining. Omi and Cleaved caspase 3 expressions in nerve cells were determined by double staining using IF. Apoptosis-related proteins were measured by Western blotting assay. Results SAH rat model was successfully established, showing more apoptotic cells and high neurological deficit scores in SAH rat. In SAH rat model, Omi expression in nerve cells was elevated and the upregulation of Omi mainly occurred in cytoplasm, accompanied by the degradation of XIAP and the increased cleaved caspase 3/9 and cleaved PARP. Once treated with UCF-101, a specific inhibitor of Omi, the increased cell apoptosis, left/right brain moisture contents and neurological deficits were notably reversed in SAH rat brain. Of note, SAH-induced the increases of apoptosis-related protein in nerve cells were also rescued by the administration of UCF-101. Conclusions UCF-101-mediated Omi inhibition decreased the degradation of XIAP and subsequently inhibited the activation of apoptosis-related proteins, decreased nerve cell apoptosis, leading to the improvement on early brain injury in SAH rat. UCF-101-based Omi inhibition may be used to treat SAH with great potential application.

Identification and Expression Analyses of the Special 14–3-3 Gene Family in Papaya and its Involvement in Fruit Development, Ripening, and Abiotic Stress Responses - Meiying Li; Licheng Ren; Zhi Zou; Wei Hu; Susheng Xiao; Xiaoliang Yang; Zehong Ding; Yan Yan; Weiwei Tie; Jinghao Yang; Anping Guo (Biochemical Genetics, 2021)

Prediction model of fractal dimensions of rock roadway formation by blasting based on Weibull distribution - Renshu Yang; Chenglong Xiao; Chenxi Ding; Peng Xu; Yong Zhao; Guoli Shi (Arabian Journal of Geosciences, 2021)

Immersion vaccines against Yersinia ruckeri infection in rainbow trout: Comparative effects of strain differences - He Yang; Ding Zhujin; Moonika H. Marana; Inger Dalsgaard; Jaafar Rzgar; Mathiessen Heidi; Karami M. Asma; Kania W. Per; Buchmann Kurt (Journal of Fish Diseases, 2021)
The protective effects of autogenous and commercial ERM immersion vaccines (bacterins based on Yersinia ruckeri, serotype O1, biotypes 1 and 2) for rainbow trout ( Oncorhynchus mykiss ) were compared in order to evaluate whether the use of local pathogen strains for immunization can improve protection. In addition, the effect of the bacterin concentration was established for the commercial product. Following sublethal challenge of vaccinated and non‐vaccinated control fish with live bacteria, we followed the bacterial count in the fish (gills, liver and spleen). The expression of genes encoding immune factors (IL‐1β, IL‐6, IL‐8, IL‐10, IFN‐γ, MHCI, MHCII, CD4, CD8, TCRβ, IgM, IgT, IgD, cathelicidins 1 and 2, SAA and C3) and densities of immune cells in organs were recorded. Both vaccines conferred protection as judged from the reduced bacterial load in exposed fish. Innate immune genes were upregulated in all groups following bacterial challenge but significantly more in non‐vaccinated naive fish in which densities of SAA‐positive immune cells increased. Immunoglobulin genes were upregulated on day 5 post‐challenge, and fish vaccinated with the high commercial bacterin dosage showed increased IgM levels by ELISA on day 14 post‐challenge, reflecting that the vaccine dosage was correlated to protection. In conclusion, both vaccine types offered protection to rainbow trout when exposed to live Y. ruckeri and no significant difference between commercial and autogenous vaccines was established.

A sesquiterpenoid from Ligularia pleurocaulis modulated macrophages polarisation through TLR4 pathway - Yang Hu; Hua Yang; Xiaoqian Ding; Lijun Tao; Minyan Liu; Chaofeng Zhang (Natural Product Research, 2021)

Correction to: Foliation Effects on Mechanical and Failure Characteristics of Slate in 3D Space Under Brazilian Test Conditions - Changdong Ding; Yang Zhang; Dawei Hu; Hui Zhou; Jianfu Shao (Rock Mechanics and Rock Engineering, 2021)

Deep rice root systems reduce methane emissions in rice paddies - Huina Ding; Yang Jiang; Cougui Cao (Plant and Soil, 2021)

Comparative activities of sitafloxacin against recent clinical isolates in hospitals across China - Shi Wu; Yang Yang; Yan Guo; Dandan Yin; Yonggui Zheng; Renru Han; Li Ding; Demei Zhu; Fupin Hu (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Associations between air pollution exposure and birth defects: a time series analysis - Shu Sun; Qi Zhang; Xinmiao Sui; Liu Ding; Jie Liu; Mei Yang; Qihong Zhao; Chao Zhang; Jiahu Hao; Xiujun Zhang; Shilei Lin; Rui Ding; et al. (Environmental Geochemistry and Health, 2021)

Comparison of the Bulk and Rhizosphere Soil Prokaryotic Communities Between Wild and Reintroduced Manglietiastrum sinicum Plants, a Threatened Species with Extremely Small Populations - Dai-Fa Su; Qing-Qing Shen; Jun-Yu Yang; Zhi-Ying Li; Wei Xiao; Yong-Xia Wang; Zhang-Gui Ding; Xiao-Long Cui (Current Microbiology, 2021)

Screening and heterologous expression of flavone synthase and flavonol synthase to catalyze hesperetin to diosmetin - Zhen Wang; Xu Huang; Juan Liu; Feiyao Xiao; Miaomiao Tian; Shenghua Ding; Yang Shan (Biotechnology Letters, 2021)

Diversity and abundance of diazotrophic communities of seagrass Halophila ovalis based on genomic and transcript level in Daya Bay, South China Sea - Weiguo Zhou; Dewen Ding; Qingsong Yang; Juan Ling; Manzoor Ahmad; Xiancheng Lin; Liyun Lin; Ying Zhang; Junde Dong (Archives of Microbiology, 2021)

Geochemistry of the Lower Cretaceous limestones in the Eastern Tethys Gyabula Formation (Himalaya, southern Tibet): implications for the depositional environment and tectonic setting - Qing Li; Feng Ding; Micha Ruhl; Yongdong Wang; Ying Li; Lei Yang; Kunzhi Xu; Xiangang Xie (Arabian Journal of Geosciences, 2021)

Combination of Polyethylene Glycol-Conjugated Urokinase Nanogels and Urokinase for Acute Ischemic Stroke Therapeutic Implications - Ding Nan; Haiqiang Jin; Di Yang; Weiwei Yu; Jingjing Jia; Zemou Yu; Hui Tan; Yongan Sun; Hongjun Hao; Xiaozhong Qu; Yining Huang (Translational Stroke Research, 2021)

Loss of MIC60 Aggravates Neuronal Death by Inducing Mitochondrial Dysfunction in a Rat Model of Intracerebral Hemorrhage - Ruming Deng; Wenjie Wang; Xiang Xu; Jiasheng Ding; Jiahe Wang; Siyuan Yang; Haiying Li; Haitao Shen; Xiang Li; Gang Chen (Molecular Neurobiology, 2021)

Evaluating the mercury distribution and release risks in sediments using high-resolution technology in Nansi Lake, China - Min Zhang; Cai Li; Xin Ma; Liyuan Yang; Shiming Ding (Journal of Soils and Sediments, 2021)

Depression Augments Plasma APOA4 without Changes of Plasma Lipids and Glucose in Female Adolescents Carrying G Allele of APOA4 rs5104 - Qi Wei Guo; Yan Jun Si; Yi Lin Shen; Xu Chen; Mei Yang; Ding Zhi Fang; Jia Lin (Journal of Molecular Neuroscience, 2021)

Apportioning above- and below-ground effects of moss biocrusts on soil detachment by overland flow in a subtropical climate - Guan-hua Zhang; Liang Yi; Wen-feng Ding; Xu Lei; Yi-ran Wang; Bao-yang Sun; Jian-ming Li (Journal of Mountain Science, 2021)

Research on the evolution law of permafrost under the influence of urbanization based on remote sensing technology - Kai Gao; Yanjie Liu; Lin Ding; Shuai Huang; Kaichi Qiu; Zhongpan Wang; Yang Yang; Xing Liu; Jiaxin Li (Earthquake Engineering and Engineering Vibration, 2021)

High-frequency interference waves in low strain dynamic testing of X-section concrete piles - Liming Qu; Yuming Fan; Xuanming Ding; Changwei Yang; Yanling Zhang (Earthquake Engineering and Engineering Vibration, 2021)

Retraction Note to: CiRS-126 inhibits proliferation of ovarian granulosa cells through targeting the miR-21-PDCD4-ROS axis in a polycystic ovarian syndrome model - Jiafeng Lu; Ying Xue; Yuhang Wang; Yang Ding; Qinyan Zou; Min Pan; Longwei Qiao; Chunhua Zhang; Qinyu Ge; Ting Wang; Hong Li (Cell and Tissue Research, 2021)

Coordinated development of agricultural water resources and the socio‐economy in Shanxi province considering uncertainty * - Gaiqiang Yang; Lirui Ding; Lijuan Huo; Yuxian Hu (Irrigation and Drainage, 2021)
The conflict between agricultural water resources and socio‐economic development is a global problem. Accurate evaluation of coordinated development of agricultural water resources and socio‐economic factors and risk mitigation is necessary for sustainable development under uncertainty. In order to accurately evaluate the coordination between agricultural water resources and socio‐economic development under uncertainty, an evaluation method was applied in this study by coupling an analytic hierarchy process method with an uncertainty analysis method. The evaluation method, including selection of criteria, data collection, determination of indicator weights, evaluation of coordinated development, prediction of parameters, and judgment of coordinated development state, has been proposed to study the degree of coordinated development. To deal with uncertainties, the Monte Carlo method and the fuzzy set method were used. The overall method was demonstrated to solve a real‐world evaluation problem in Shanxi province, China. Results showed that degrees of coordinated development were (0.7, 0.8) for most of the cities in Shanxi in 2015, indicating that the state of coordinated development was intermediate. In 2020, the degree of coordinated development was expected to markedly decrease, the state of coordinated development to be minimal, and agricultural water resources utilization to lag behind socio‐economic development.

Reduction of mussel metamorphosis by inactivation of the bacterial thioesterase gene via alteration of the fatty acid composition - Xiao-Meng Hu; Junbo Zhang; Wen-Yang Ding; Xiao Liang; Rong Wan; Sergey Dobretsov; Jin-Long Yang (Biofouling, 2021)

Shelf-Life Prediction of Glazed Large Yellow Croaker (Pseudosciaena crocea) during Frozen Storage Based on Arrhenius Model and Long-Short-Term Memory Neural Networks Model - Yuanming Chu; Mingtang Tan; Zhengkai Yi; Zhaoyang Ding; Dazhang Yang; Jing Xie (Fishes, 2021)
In this study, the changes in centrifugal loss, TVB-N, K-value, whiteness and sensory evaluation of glazed large yellow croaker were analyzed at −10, −20, −30 and −40 °C storage. The Arrhenius prediction model and long-short-term memory neural networks (LSTM-NN) prediction model were developed to predict the shelf-life of the glazed large yellow croaker. The results showed that the quality of glazed large yellow croaker gradually decreased with the extension of frozen storage time, and the decrease in quality slowed down at lower temperatures. Both the Arrhenius model and the LSTM-NN prediction model were good tools for predicting the shelf-life of glazed large yellow croaker. However, for the relative error, the prediction accuracy of LSTM-NN (with a mean value of 7.78%) was higher than that of Arrhenius model (with a mean value of 11.90%). Moreover, the LSTM-NN model had a more intelligent, convenient and fast data processing capability, so the new LSTM-NN model provided a better choice for predicting the shelf-life of glazed large yellow croaker.

Association between large artery stenosis, cerebral small vessel disease and risk of ischemic stroke - Fei Han; Ding-Ding Zhang; Fei-Fei Zhai; Jun Xue; Jiang-Tao Zhang; Shuang Yan; Li-Xin Zhou; Jun Ni; Ming Yao; Meng Yang; Ming-Li Li; Zheng-Yu Jin; et al. (Science China Life Sciences, 2021)

Construction of a high-density genetic linkage map and QTL analysis of morphological traits in an F1 Malusdomestica × Malus baccata hybrid - Huacheng Cai; Qian Wang; Jingdong Gao; Chunyan Li; Xuemei Du; Baopeng Ding; Tingzhen Yang (Physiology and Molecular Biology of Plants, 2021)

The ATP Level in the mPFC Mediates the Antidepressant Effect of Calorie Restriction - Qian Wang; Ying Kong; Song Lin; Ding-Yu Wu; Jian Hu; Lang Huang; Wen-Si Zang; Xiao-Wen Li; Jian-Ming Yang; Tian-Ming Gao (Neuroscience Bulletin, 2021)

ACHP: A Web Server for Predicting Anti-Cancer Peptide and Anti-Hypertensive Peptide - Deling Xu; Yanyan Wu; Zhixing Cheng; Jing Yang; Yanrui Ding (International Journal of Peptide Research and Therapeutics, 2021)

Study on the comprehensive utilization of solid residues of Flammulina velutipes and vinegar and their application as feed in Eisenia fetida earthworm culture - Tong Xu; Fan Fei; Yangyang Ding; Yongchao Liu; Guanghua Mao; Liuqing Yang; Ting Zhao; Taotao Liao; Weiwei Feng; Xiangyang Wu (Environmental Science and Pollution Research, 2021)

Jatrophacine, a 4,5- seco -rhamnofolane diterpenoid with potent anti-inflammatory activity from Jatropha curcas - Yang Hu; Huimin Zhao; Aiping Yang; Qi Lv; Ning Ding; Tu-Lin Lu; Lihong Hu; Xiachang Wang (Natural Product Research, 2021)

Flexural Toppling Mechanism and Stability Analysis of an Anti-dip Rock Slope - Bingdong Ding; Zhangyi Han; Guangcheng Zhang; Xingtao Beng; Yichen Yang (Rock Mechanics and Rock Engineering, 2021)

Design, synthesis, biological evaluation, and molecular docking of 1,7-dibenzyl-substituted theophylline derivatives as novel BRD4-BD1-selective inhibitors - Yingjie Chang; Jinge Zhang; Shuangshuang Yang; Wanying Lu; Lina Ding; Yichao Zheng; Wen Li (Medicinal Chemistry Research, 2021)

Construction and application of easy-to-detect cyanobacteria with vp28 gene - Min-Min Zhuang; Wen Peng; Yang Xu; Xiao-Hui Jia; Ding-Ji Shi; Pei-Min He; Rui Jia (Journal of Applied Phycology, 2021)

Microfiber pollution: an ongoing major environmental issue related to the sustainable development of textile and clothing industry - Jianli Liu; Jianyao Liang; Jiannan Ding; Guangming Zhang; Xianyi Zeng; Qingbo Yang; Bo Zhu; Weidong Gao (Environment, Development and Sustainability, 2021)

Altered gray matter structural covariance networks at both acute and chronic stages of mild traumatic brain injury - Jie Song; Jie Li; Lixiang Chen; Xingqi Lu; Senning Zheng; Ying Yang; Bolin Cao; Yihe Weng; Qinyuan Chen; Jianping Ding; Ruiwang Huang (Brain Imaging and Behavior, 2021)

Quantifying nitrate pollution sources of the drinking water source area using a Bayesian isotope mixing model in the northeastern suburbs of Beijing, China - Liangsuo Ren; Lirong Cheng; Shurong Zhang; Aizhong Ding; Yi Zhu; Chunlei Lu; Yu Li; Qing Yang; Jie Li (Isotopes in Environmental and Health Studies, 2021)

Myosin light chain 2 marks differentiating ventricular cardiomyocytes derived from human embryonic stem cells - Xiao-Ling Luo; Peng Zhang; Xiangyuan Liu; Shiqian Huang; Sen-Le Rao; Qiurong Ding; Huang-Tian Yang (Pflügers Archiv - European Journal of Physiology, 2021)

Individual variation in metabolic rate, locomotion capacity and hypoxia tolerance and their relationships in juveniles of three freshwater fish species - Xu Pang; De-Yong Pu; Dan-Yang Xia; Xiao-Hong Liu; Shi-Hua Ding; Yun Li; Shi-Jian Fu (Journal of Comparative Physiology B, 2021)

Thermosensitive quaternized chitosan hydrogel scaffolds promote neural differentiation in bone marrow mesenchymal stem cells and functional recovery in a rat spinal cord injury model - Cheng Huang; Yuanbing Liu; Jian Ding; Yongping Dai; Lixiang Le; Liangliang Wang; Erhu Ding; Jiandong Yang (Cell and Tissue Research, 2021)

Remodeling of Arctic char ( Salvelinus alpinus ) lipidome under a stimulated scenario of Arctic warming - Chao Wang; Yufeng Gong; Fuchang Deng; Enmin Ding; Jie Tang; Garry Codling; Jonathan K. Challis; Derek Green; Jing Wang; Qiliang Chen; Yuwei Xie; Shu Su; et al. (Global Change Biology, 2021)
Arctic warming associated with global climate change poses a significant threat to populations of wildlife in the Arctic. Since lipids play a vital role in adaptation of organisms to variations in temperature, high‐resolution mass‐spectrometry‐based lipidomics can provide insights into adaptive responses of organisms to a warmer environment in the Arctic and help to illustrate potential novel roles of lipids in the process of thermal adaption. In this study, we studied an ecologically and economically important species—Arctic char ( Salvelinus alpinus )—with a detailed multi‐tissue analysis of the lipidome in response to chronic shifts in temperature using a validated lipidomics workflow. In addition, dynamic alterations in the hepatic lipidome during the time course of shifts in temperature were also characterized. Our results showed that early life stages of Arctic char were more susceptible to variations in temperature. One‐year‐old Arctic char responded to chronic increases in temperature with coordinated regulation of lipids, including headgroup‐specific remodeling of acyl chains in glycerophospholipids (GP) and extensive alterations in composition of lipids in membranes, such as less lyso‐GPs, and more ether‐GPs and sphingomyelin. Glycerolipids (e.g., triacylglycerol, TG) also participated in adaptive responses of the lipidome of Arctic char. Eight‐week‐old Arctic char exhibited rapid adaptive alterations of the hepatic lipidome to stepwise decreases in temperature while showing blunted responses to gradual increases in temperature, implying an inability to adapt rapidly to warmer environments. Three common phosphatidylethanolamines (PEs) (PE 36:6|PE 16:1_20:5, PE 38:7|PE 16:1_22:6, and PE 40:7|PE 18:1_22:6) were finally identified as candidate lipid biomarkers for temperature shifts via machine learning approach. Overall, this work provides additional information to a better understanding of underlying regulatory mechanisms of the lipidome of Arctic organisms in the face of near‐future warming.

Analysis of Seismic Damage Zones: A Case Study of the Ordovician Formation in the Shunbei 5 Fault Zone, Tarim Basin, China - Zhan Zhao; Jingtao Liu; Wenlong Ding; Ruiqiang Yang; Gang Zhao (Journal of Marine Science and Engineering, 2021)
Fault damage zone has an important influence on subsurface fluid flow and petrophysical properties. Therefore, it is of great significance to study the characteristics of fault damage zone for oil and gas development of ultra-deep carbonate formation. This study uses seismic data and the derived variance attribute to identify two types of damage zones and analyze the spatial geometric characteristics of the damage zones. The results show that the type 1 damage zone is wider than the type 2 damage zone. The width of damage zones distributed on both sides of the Shunbei 5 fault core shows obvious asymmetry, and the damage zone width and throw conforms to the typical power-law distribution on the log-log plot. We discuss the factors affecting the width of the damage zone and its formation process. Finally, we discuss the influence of the damage zones on oil and gas exploration. It seems that the seismic variance attribute is a useful technique for characterizing the ultra-deep strike-slip fault damage zones.

Programmed sequential cutting endows Cas9 versatile base substitution capability in plants - Wei Yang; Wei Qi; Yucai Li; Jiyao Wang; Yanmin Luo; Dehui Ding; Sudong Mo; Bo Chen; Yu Lu; Huarong Li; Linjian Jiang (Science China Life Sciences, 2021)

A New Approach to Embed Complex Fracture Network in Tight Oil Reservoir and Well Productivity Analysis - Jiaxiang Xu; Lifeng Yang; Zhe Liu; Yunhong Ding; Rui Gao; Zhen Wang; Shaoyuan Mo (Natural Resources Research, 2021)

Understanding the failure mechanism of a large underground cavern in steeply dipping layered rock mass using an enhanced ubiquitous-joint model - Yang-Yi Zhou; Ding-Ping Xu; Ke Liu; Dong-Fang Chen (Bulletin of Engineering Geology and the Environment, 2021)

Numerical analysis of deep hole multi-stage cut blasting of vertical shaft using a continuum-based discrete element method - Chenxi Ding; Renshu Yang; Changda Zheng; Liyun Yang; Songlin He; Chun Feng (Arabian Journal of Geosciences, 2021)

The resurgent landscape of xenotransplantation of pig organs in nonhuman primates - Xuan Zhang; Quancheng Wang; Jingjun Zhao; Xiao Li; Wei Peng; Zhaoxu Yang; Zhibin Lin; Long Yang; Rui Ding; Kaishan Tao; Kefeng Dou (Science China Life Sciences, 2021)

Modeled Stokes drift in the marginal ice zones of the Arctic Ocean - Jingkai Li; Rui Li; Yang Ding; Yunrui Ma (Ocean Dynamics, 2021)

KCNQ Channels in the Mesolimbic Reward Circuit Regulate Nociception in Chronic Pain in Mice - Hao-Ran Wang; Su-Wan Hu; Song Zhang; Yu Song; Xiao-Yi Wang; Lei Wang; Yang-Yang Li; Yu-Mei Yu; He Liu; Di Liu; Hai-Lei Ding; Jun-Li Cao (Neuroscience Bulletin, 2021)
Mesocorticolimbic dopaminergic (DA) neurons have been implicated in regulating nociception in chronic pain, yet the mechanisms are barely understood. Here, we found that chronic constructive injury (CCI) in mice increased the firing activity and decreased the KCNQ channel-mediated M-currents in ventral tegmental area (VTA) DA neurons projecting to the nucleus accumbens (NAc). Chemogenetic inhibition of the VTA-to-NAc DA neurons alleviated CCI-induced thermal nociception. Opposite changes in the firing activity and M-currents were recorded in VTA DA neurons projecting to the medial prefrontal cortex (mPFC) but did not affect nociception. In addition, intra-VTA injection of retigabine, a KCNQ opener, while reversing the changes of the VTA-to-NAc DA neurons, alleviated CCI-induced nociception, and this was abolished by injecting exogenous BDNF into the NAc. Taken together, these findings highlight a vital role of KCNQ channel-mediated modulation of mesolimbic DA activity in regulating thermal nociception in the chronic pain state.

Fluvastatin attenuated ischemia/reperfusion-induced autophagy and apoptosis in cardiomyocytes through down-regulation HMGB1/TLR4 signaling pathway - Hua-Sheng Ding; Jun Yang; Jian Yang; Xin Guo; Yan-Hong Tang; Yan Huang; Zhen Chen; Zhi-Xing Fan; Cong-Xin Huang (Molecular Biology Reports, 2021)

Dual-Specificity Phosphatase 15 (DUSP15) Modulates Notch Signaling by Enhancing the Stability of Notch Protein - Noopur Bhore; Bo-Jeng Wang; Po-Fan Wu; Yen-Lurk Lee; Yun-Wen Chen; Wen-Ming Hsu; Hsinyu Lee; Yi-Shuian Huang; Ding-I Yang; Yung-Feng Liao (Molecular Neurobiology, 2021)

New insights into the fine-scale history of western–eastern admixture of the northwestern Chinese population in the Hexi Corridor via genome-wide genetic legacy - Hongbin Yao; Mengge Wang; Xing Zou; Yingxiang Li; Xiaomin Yang; Ailin Li; Hui-Yuan Yeh; Peixin Wang; Zheng Wang; Jingya Bai; Jianxin Guo; Jinwen Chen; et al. (Molecular Genetics and Genomics, 2021)

Bi-allelic BRWD1 variants cause male infertility with asthenoteratozoospermia and likely primary ciliary dyskinesia - Ting Guo; Chao-Feng Tu; Dan-Hui Yang; Shui-Zi Ding; Cheng Lei; Rong-Chun Wang; Lv Liu; Xi Kang; Xiao-Qing Shen; Yi-Feng Yang; Zhi-Ping Tan; Yue-Qiu Tan; et al. (Human Genetics, 2021)

Characterizing temporal behavior of a thermal tracer in porous media by time-lapse electrical resistivity measurements - Ze Yang; Yaping Deng; Jiazhong Qian; Rui Ding; Lei Ma (Hydrogeology Journal, 2021)

Montmorillonite-supported nanoscale zero-valent iron for thiamethoxam removal: response surface optimization and degradation pathway - Chunxia Ding; Wei-ai Zeng; A-juan Zhao; Mengyun Yang; Yanlan Xie; Yaocheng Deng; Daoxin Gong; Meizheng Duan; Hailin Cai; Pengfei Xie; Yong Zhou; Zhiyong Wen (Environmental Science and Pollution Research, 2021)

Two new 3-hexenol glycosides from the calyces of Physalis alkekengi var. franchetii - Zunpeng Shu; Yun Tang; Yanni Yang; Zihe Ding; Renxing Zhong; Tianyi Xia; Xinjia Li; Cuiying Zheng; Zhixiong Wen; Wei Li; Yi Wang (Natural Product Research, 2021)

Design and experimental study of an effective, low-cost, naturally ventilated radiation shield for monitoring surface air temperature - Jie Yang; Xuan Deng; Qingquan Liu; Renhui Ding (Meteorology and Atmospheric Physics, 2021)

Rhizosphere microbiome dynamics in tropical seagrass under short-term inorganic nitrogen fertilization - Weiguo Zhou; Junde Dong; Dewen Ding; Lijuan Long; Anning Suo; Xiancheng Lin; Qingsong Yang; Liyun Lin; Yanying Zhang; Juan Ling (Environmental Science and Pollution Research, 2021)

Abnormalities in the thalamo-cortical network in patients with functional constipation - Lei Liu; Chunxin Hu; Yang Hu; Wenchao Zhang; Zhida Zhang; Yueyan Ding; Yuanyuan Wang; Karen M. von Deneen; Lijuan Sun; Huaning Wang; Shijun Duan; Kuanrong Mao; et al. (Brain Imaging and Behavior, 2021)

Altered resting-state functional networks in patients with hemodialysis: a graph-theoretical based study - Mei Jin; Liyan Wang; Hao Wang; Xue Han; Zongli Diao; Wang Guo; Zhenghan Yang; Heyu Ding; Zheng Wang; Peng Zhang; Pengfei Zhao; Han Lv; et al. (Brain Imaging and Behavior, 2021)

miR-491-3p is Downregulated in Retinoblastoma and Inhibit Tumor Cells Growth and Metastasis by Targeting SNN - Yang Hu; Ming Zhao; Li Li; Jie Ding; Yu-Min Gui; Tan-Wei Wei (Biochemical Genetics, 2021)
Retinoblastoma (Rb) is the most common pediatric malignant tumor of the eyes. Previous studies demonstrated that miR-491-3p is downregulated in various cancers. However, its function in Rb remains unknown. A total of 15 pairs of primary Rb tissues and adjacent noncancerous tissues were collected. Quantitative real-time PCR (qRT-PCR) was used to investigate the expression profiles of miR-491-3p. qRT-PCR, western blotting and in situ immunocytochemistry were performed to investigate the expression profiles of epithelial–mesenchymal transition-related proteins (E-cadherin, Vimentin and N-cadherin) in Rb tissues and Rb cell lines as well as cell morphology. Cell proliferation was estimated by MTS and colony formation assays. Apoptosis was determined by FACS, cell migration and invasion were analyzed using transwell chambers. MiR-491-3p’s target genes were predicted using target gene prediction databases. The interplay between miR-491-3p and SNN was evaluated through dual luciferase reporter gene assay. MiR-491-3p was significantly downregulated in mixed collection of 15 pairs of Rb tissues and Rb cell lines. Overexpression of miR-491-3p enhanced apoptosis, and significantly suppressed proliferation, migration and invasion of Rb cells. In contrast, the present of miR-491-3p inhibitor showed reversed results which apoptosis decreased, while cell proliferation of ARPE-19 cells increased. In addition, miR-491-3p increased the expression of E-cadherin, and dramatically decreased the expression of Vimentin and N-cadherin in Rb tissues and Rb cell lines, noticeable changes in morphology, too, as cells became less cohesive and more adhering. We found out that SNN was the pairing target of miR-491-3p and result showed that miR-491-3p and SNN interacted with each other. We also found out that the effects of miR-491-3p were in Rb cells were almost entirely canceled out at the overexpression of SNN. Our findings collectively suggest that miR-491-3p is an important tumor suppressor in Rb, which inhibits tumor growth and metastasis in Rb. These implicate it may be explored as a new therapeutic target in Rb.

Numerical simulations of lowering boulder yield based on delay time and double-primer initiation - Renshu Yang; Yong Zhao; Chenxi Ding; Jinjing Zuo; Yatian Liu; Liyun Ding (Arabian Journal of Geosciences, 2021)

Salinity and nutrient modulate soil bacterial communities in the coastal wetland of the Yellow River Delta, China - Qingli Cheng; Huiping Chang; Xue Yang; Ding Wang; Wenlin Wang (Environmental Science and Pollution Research, 2021)

Effects of traditional block morphology on wind environment at the pedestrian level in cold regions of Xi’an, China - Wei Feng; Wei Ding; Miaomiao Fei; Yujun Yang; Weihan Zou; Ling Wang; Meng Zhen (Environment, Development and Sustainability, 2021)

Green reclaiming of riboflavin from crystallization mother liquor by macroporous resin and electrodialysis - Amjad Hussain Memon; Runsheng Ding; Yi Guo; Feibao Tian; Jianhua Hu; Zijian Yang; Hao Liang (Environment, Development and Sustainability, 2021)

Exploring the secrets of brain transcriptional regulation: developing methodologies, recent significant findings, and perspectives - Zhe Ding; Luyun Sun; Cen Yang; Aihua Liu; Fukai Bao (Brain Structure and Function, 2021)

Development and characterization of 31 SNP markers for the Crested ibis (Nipponia nippon) - Wenhui Niu; Yongjie Huang; Chenglin Zhang; Tianchun Pu; Yan Lu; Ting Jia; Yuyan You; Yang Du; Yu Mao; Changqing Ding (Conservation Genetics Resources, 2021)

Metabolomics analysis for skin ulceration syndrome of Apostichopus japonicus based on UPLC/Q-TOF MS - Yang Zhang; Youquan Wang; Xiaoyu Liu; Beichen Ding; Yi Sun; Yaqing Chang; Jun Ding (Journal of Oceanology and Limnology, 2021)

Down-regulation of MANNANASE7 gene in Brassica napus L. enhances silique dehiscence-resistance - Yu-Long Li; Yan-Kun Yu; Ke-Ming Zhu; Li-Na Ding; Zheng Wang; Yan-Hua Yang; Jun Cao; Li-Zhang Xu; Yao-Ming Li; Xiao-Li Tan (Plant Cell Reports, 2021)

Molecular Regulatory Mechanism and Toxicology of Neurodegenerative Processes in MPTP/Probenecid-Induced Progressive Parkinson’s Disease Mice Model Revealed by Transcriptome - Weiwei Yang; Wenwen Hao; Zhuo Meng; Shiyan Ding; Xiaodi Li; Tao Zhang; Weixiao Huang; Lian Xu; Yu Zhang; Jian Yang; Xiaosong Gu (Molecular Neurobiology, 2021)
Parkinson’s disease (PD) is a neurodegenerative disease caused by a variety of unclear complex pathogenic factors. The 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine/probenecid (MPTP/p)-induced progressive PD mice is a well-recognized classic model for studying PD, but the molecular toxicology of this model is still unclear. Here, for the first time, we report gradual neurodegenerative processes in MPTP/p-induced progressive PD mice model using RNA-seq. Transcriptional responses are orchestrated to regulate the expression of many genes in substantia nigra, such as Ntf3 , Pitx3 , Th , and Drd2 , leading to the degeneration of dopaminergic neurons at last. We proposed that the established model could be divided into three phases based on their molecular toxicological features: “the stress response phase” which maintained the microenvironment homeostasis, “the pre-neurodegenerative phase” which demonstrated observed MPTP/p cytotoxicity and gradual degeneration of dopaminergic neurons, and “the neurodegenerative phase” which reflected distinct damage and dopaminergic neuron apoptotic process. Glia cells exhibited a certain protective effect on dopaminergic neurons in 3rd and 6th MPTP/p-induced cytotoxicity. But in 10th MPTP/p injection, glia cells play a promoting role in PD and tissue damages caused by oxidative stress. This study also indicated that the substantia nigra of PD mice showed unique patterns of changes at each stage. Moreover, neurotrophic signaling pathway, ECM-receptor interaction, oxidative phosphorylation, apoptosis and necroptosis were enriched at 3rd and 6th MPTP/p injection, which might be associated with the PD progress. This study provided an extensive data set of molecular toxicology for elucidating of PD progression and offered comprehensive theoretical knowledge for the development of new therapy.

First report of cucumber mosaic virus infecting Morinda officinalis in China - Chong Feng; Ti-Jiang Shan; Li Yang; Miao-Miao Cai; De-Po Yang; Zhi-Min Zhao; Ping Ding (Journal of Plant Pathology, 2021)

Effects of seasonal ambient heat stress on expression of microRNAs in the mammary gland of Holstein cows - Caiyun Fan; Ruiting Hu; Haixiao Fan; Ying Yang; Bin Gong; Shaoze Zhang; Jianping Ding; Yanjing Su; Zhao Zhuo; Jianbo Cheng (International Journal of Biometeorology, 2021)

Potential risk assessment of groundwater to address the agricultural and domestic challenges in Ordos Basin - Lujiao Ding; Qingchun Yang; Yuesuo Yang; Hongyun Ma; Jordi Delgado Martin (Environmental Geochemistry and Health, 2021)

An Environmental Dilemma for China During the COVID-19 Pandemic: The Explosion of Disposable Plastic Wastes - Jianli Liu; A. Dick Vethaak; Lihui An; Qiang Liu; Yunfei Yang; Jiannan Ding (Bulletin of Environmental Contamination and Toxicology, 2021)

Cerebral blood flow alterations in hemodialysis patients with and without restless legs syndrome: an arterial spin labeling study - Hao Wang; Xue Han; Mei Jin; Li-yan Wang; Zong-li Diao; Wang Guo; Peng Zhang; Zheng Wang; Han Lv; He-yu Ding; Zheng-yu Zhang; Peng-fei Zhao; et al. (Brain Imaging and Behavior, 2021)

Controlled-release N fertilizer to mitigate ammonia volatilization from double-cropping rice - Chang Tian; Xuan Zhou; Zheli Ding; Qiang Liu; Guixian Xie; Jianwei Peng; Xiangming Rong; Yuping Zhang; Yong Yang; Mamdouh A. Eissa (Nutrient Cycling in Agroecosystems, 2021)
Controlled-release nitrogen fertilizer (CRNF) can effectively enhance crop yields and raise the efficiency of nitrogen fertilizer in agroecosystems. In the present study, the volatilization of NH 3 was determined by airflow enclosure chamber technique after the application of different CRNF rates in double-cropping rice fields in southern China for continuous 3 years. The early and late season rice (ESR and LSR) were cultivated each year. The results showed that the total NH 3 volatilization losses ranged from 25 to 56 kg N ha −1 in ESR and from 32 to 61 kg N ha −1 in LSR. The loss of N to the total applied N ranged from 12 to 29% in ESR and from 12 to 27% in LSR. The application of CRNF significantly reduced the cumulative NH 3 volatilization losses by 20–43% for ESR and by 20–32% for LSR compared with conventional urea application. CRNF in LSR was less effective to reduce NH 3 volatilization than that in ESR. Furthermore, the application of 80% of N rate in the form of CRNF gave higher grain yield and apparent nitrogen recovery efficiency (ANRE) than that of application of 100% of N rate from conventional urea. CRNF can effectively reduce NH 3 volatilization, and increase rice yield and ANRE. Considering higher price of CRNF, the application of CRNF at lower (20% applied N) rate than conventional urea in LSR may be a reasonable fertilization strategy for improving N use efficiency, environment effectiveness, and sustaining the development of rice production systems in double-cropping rice.

The sensitivity of numerical simulation to vertical mixing parameterization schemes: a case study for the Yellow Sea Cold Water Mass - Congcong Bi; Zhigang Yao; Xianwen Bao; Cong Zhang; Yang Ding; Xihui Liu; Junru Guo (Journal of Oceanology and Limnology, 2021)

Recovery experiences mediate the effect of burnout on life satisfaction among Chinese physicians: a structural equation modeling analysis - Yang Song; Yajing Jia; Kristin Sznajder; Jialin Ding; Xiaoshi Yang (International Archives of Occupational and Environmental Health, 2021)

Comparative analysis of mitochondrial genomes of soybean cytoplasmic male-sterile lines and their maintainer lines - Tingting He; Xianlong Ding; Hao Zhang; Yanwei Li; Linfeng Chen; Tanliu Wang; Longshu Yang; Zhixing Nie; Qijian Song; Junyi Gai; Shouping Yang (Functional & Integrative Genomics, 2021)

High-resolution Simulation of an Extreme Heavy Rainfall Event in Shanghai Using the Weather Research and Forecasting Model: Sensitivity to Planetary Boundary Layer Parameterization - Rui Wang; Yiting Zhu; Fengxue Qiao; Xin-Zhong Liang; Han Zhang; Yang Ding (Advances in Atmospheric Sciences, 2021)

Shear-Thinning Viscous Materials for Subconjunctival Injection of Microparticles - Shiyu Xia; Zheng Ding; Lixia Luo; Baiwei Chen; Joanna Schneider; Jin Yang; Charles G. Eberhart; Walter J. Stark; Qingguo Xu (AAPS PharmSciTech, 2021)

Research progress on gut health of farmers teleost fish: a viewpoint concerning the intestinal mucosal barrier and the impact of its damage - Hongling Zhang; Chao Ran; Tsegay Teame; Qianwen Ding; Seyed Hossein Hoseinifar; Mingxu Xie; Zhen Zhang; Yalin Yang; Rolf Erik Olsen; Delbert M. Gatlin; Einar Ringø; Ming Duan; et al. (Reviews in Fish Biology and Fisheries, 2020)

Clinical features in 52 patients with COVID-19 who have increased leukocyte count: a retrospective analysis - Kaochang Zhao; Ruiyun Li; Xiaojun Wu; Yang Zhao; Tao Wang; Zhishui Zheng; Shaolin Zeng; Xuhong Ding; Hanxiang Nie (European Journal of Clinical Microbiology & Infectious Diseases, 2020)

High heterogeneity of bacterioplankton community shaped by spatially structured environmental factors in West Lake, a typical urban lake in eastern China - Yi Du; Wen Yang; Xiuying Ding; Jinjie Zhang; Zhongming Zheng; Jinyong Zhu (Environmental Science and Pollution Research, 2020)

Analysis and prediction of land subsidence along significant linear engineering - Pengpeng Ding; Chao Jia; Shengtong Di; Linlin Wang; Chao Bian; Xiao Yang (Bulletin of Engineering Geology and the Environment, 2020)

Larger regional volume of the thalamus in diarrhea-predominant irritable bowel syndrome: a cross-sectional study - Cui Ping Mao; Fen Rong Chen; Hong Hong Sun; Mei Juan Shi; Hua Juan Yang; Xiao Hui Li; Dun Ding (Brain Imaging and Behavior, 2020)

Groundwater Hydrogeochemical Mechanisms and the Connectivity of Multilayer Aquifers in a Coal Mining Region - Zhongyuan Yang; Pinghua Huang; Fengfan Ding (Mine Water and the Environment, 2020)

Listeria rhombencephalitis mimicking acute disseminated encephalomyelitis in a patient without predisposing medical conditions - Hongna Yang; Cuilan Wang; Hao Wang; Shifang Ding (Journal of NeuroVirology, 2020)

Physiological and molecular responses to ocean acidification among strains of a model diatom - Ruiping Huang; Jiancheng Ding; Jiazhen Sun; Yang Tian; Chris Bowler; Xin Lin; Kunshan Gao (Limnology and Oceanography, 2020)
Differential responses of diatoms, an important group of marine primary producers to ocean acidification, have been well documented. However, studies so far are based on limited representative strains from key species. Investigation of strain level responses will help us better understand the contrasting discrepancy in diatom responses to ocean acidification. Here, we selected four strains of the model diatom Phaeodactylum tricornutum isolated from different regions of the global ocean, representing all genotypes based on internal transcribed spacer 2 sequences, and investigated strain‐specific responses to ocean acidification. In response to ocean acidification, changes in carbon metabolism varied among strains, although no significant effects of ocean acidification on growth rates or pigments were observed in any strains. The expression of genes encoding plasma membrane bicarbonate transporters was downregulated in strain Pt4, reflecting a potential decrease in active uptake, which was not observed in the other strains. Reduction of CO 2 concentrating mechanism efficiency was also indicated by the regulated expression of genes encoding carbonic anhydrases that catalyze the interconversion of and CO 2 in the pyrenoids and pyrenoid‐penetrating thylakoid, which exhibited different patterns among the strains. Under ocean acidification conditions, C4‐like metabolism appeared to redistribute carbon flux to gluconeogenesis in strain Pt1, and lipid synthesis in strains Pt8 and Pt11, rather than participating in net photosynthetic carbon fixation. These variations were incompletely correlated with phylogenetic relationship in different strains, implying that the habitat‐adapted imprints of the different strains could also be responsible for their differential responses to ocean acidification.

The performance of LS and SVD methods for SBAS InSAR deformation model solutions - Qiuxiang Tao; Liujian Ding; Leyin Hu; Yang Chen; Tongwen Liu (International Journal of Remote Sensing, 2020)

Estimation of surface energy fluxes in the permafrost region of the Tibetan Plateau based on in situ measurements and the surface energy balance system model - Jimin Yao; Lianglei Gu; Cheng Yang; Hao Chen; Jiemin Wang; Yongjian Ding; Ren Li; Lin Zhao; Yao Xiao; Yongping Qiao; Jianzong Shi; Caiping Chen (International Journal of Climatology, 2020)
The surface energy balance is a key issue in land surface process research and important for studies of climate and hydrology. In this paper, the surface energy fluxes (net radiation, ground heat flux, sensible heat flux and latent heat flux) at the Tanggula (TGL) and Xidatan (XDT) sites were measured and the distributions of the regional surface energy fluxes on the Tibetan Plateau were obtained using a revised surface energy balance system (SEBS) model. The results show that the surface energy fluxes have obvious seasonal variations. At both sites, the sensible heat flux is highest in spring and lowest in summer, and the latent heat flux is highest in summer and lowest in winter. The high elevation, snow cover, freeze–thaw process, precipitation, vegetation and soil texture are important influencing factors for land surface energy fluxes. The time‐phase difference between the net radiation and ground heat flux for bare soils is estimated to be 2–3 hr. The ratio of ground heat flux and net radiation ranged from approximately 0.18 to 0.33, and a parameterization scheme for the remote sensing of ground heat flux over the Tibetan Plateau bare soil in summer is developed. The simulation results of the regional surface energy fluxes show that the distributions of surface parameters, such as vegetation, soil texture and soil moisture content, are important for understanding regional changes in the surface energy fluxes.

Inducing secondary metabolite production from Daldinia eschscholzii JC-15 by red ginseng medium - Bang-Yan Wang; Ya-Bin Yang; Xue-Qiong Yang; Chen-Hao Zhu; Shuang Yang; Ting-Ting Xu; Xue-Yin Wang; Ning-Hua Tan; Hao Zhou; Zhong-Tao Ding (Natural Product Research, 2020)

Dynamic transcriptome analysis indicates extensive and discrepant transcriptomic reprogramming of two rapeseed genotypes with contrasting NUE in response to nitrogen deficiency - Ningmei Yang; Shuang Li; Sheliang Wang; Quan Li; Fangsen Xu; Lei Shi; Chuang Wang; Xiangsheng Ye; Hongmei Cai; Guangda Ding (Plant and Soil, 2020)

Negligible transcriptome and metabolome alterations in RNAi insecticidal maize against Monolepta hieroglyphica - Xiaolei Zhang; Ruiying Zhang; Liang Li; Yang Yang; Yijia Ding; Haitao Guan; Xiaoqin Wang; Aihong Zhang; Hongtao Wen (Plant Cell Reports, 2020)
Key message RNAi-based genetically modified maize resistant to Monolepta hieroglyphica (Motschulsky) was demonstrated with negligible transcriptome and metabolome alterations compared to its unmodified equivalent. Abstract As one of the most prevalent insect pests afflicting various crops, Monolepta hieroglyphica (Motschulsky) causes severe loss of agricultural and economic productivity for many years in China. In an effort to reduce damages, in this study, an RNA interference (RNAi)-based genetically modified (GM) maize was developed. It was engineered to produce MhSnf7 double-stranded RNAs (dsRNAs), which can suppress the Snf7 gene expression and then lead M. hieroglyphica to death . Field trail analysis confirmed the robustly insecticidal ability of the MhSnf7 GM maize to resist damages by M. hieroglyphica . RNA sequencing analysis identified that only one gene was differentially expressed in the MhSnf7 GM maize compared to non-GM maize, indicating that the transcriptome in MhSnf7 GM maize is principally unaffected by the introduction of the MhSnf7 dsRNA expression vector. Likewise, metabolomics analysis identified that only 8 out of 5787 metabolites were significantly changed. Hence, the integration of transcriptomics and metabolomics demonstrates that there are negligible differences between MhSnf7 GM maize and its unmodified equivalent. This study not only presents a comprehensive assessment of cellular alteration in terms of gene transcription and metabolite abundance in RNAi-based GM maize, but also could be used as a reference for evaluating the unintended effect of GM crops.

Analysis of provincial total-factor air pollution efficiency in China by using context-dependent slacks-based measure considering undesirable outputs - Ke-Liang Wang; Li-Li Ding; Jian-Min Wang; Mian Yang (Natural Hazards, 2020)

One-pot synthesis of substituted pyrrole–imidazole derivatives with anticancer activity - Ming Zhang; Yong Ding; Hong-Xia Qin; Zhi-Gang Xu; Hai-Tao Lan; Dong-Lin Yang; Cheng Yi (Molecular Diversity, 2020)

Identification and analysis of new mycoviruses from melon powdery mildew - Yushanjiang Maimaiti; Lei Ding; Min Chai; Xiaoya Jing; Du Yang; Sheng Han; Liuqing Sun; Wei Chen (Journal of Plant Pathology, 2020)

Application of DGT/DIFS combined with BCR to assess the mobility and release risk of heavy metals in the sediments of Nansi Lake, China - Min Zhang; Cai Li; Liyuan Yang; Shiming Ding; Xin Ma; You Zhang; Tingting Zhao (Environmental Geochemistry and Health, 2020)

Representing the Heat-to-Moisture Transport Efficiency in Stable Conditions: An Extension of Two Different Approaches - Xiaofeng Guo; Kun Yang; Wei Yang; Long Zhao; Shenghai Li; Baohong Ding (Asia-Pacific Journal of Atmospheric Sciences, 2020)

Sulfur isotopic compositions of sulfides along the Southwest Indian Ridge: implications for mineralization in ultramafic rocks - Teng Ding; Chunhui Tao; Ágata Alveirinho Dias; Jin Liang; Jie Chen; Bin Wu; Dongsheng Ma; Rongqing Zhang; Jia Wang; Shili Liao; Yuan Wang; Weifang Yang; et al. (Mineralium Deposita, 2020)

Wave Simulation by the SWAN Model and FVCOM Considering the Sea-Water Level around the Zhoushan Islands - Zhehao Yang; Weizeng Shao; Yang Ding; Jian Shi; Qiyan Ji (Journal of Marine Science and Engineering, 2020)
In this study, the numerical wave model Simulating Waves Nearshore (SWAN), which resolves nearshore wave processes, and a hydrodynamic model, the Finite-Volume Community Ocean Model (FVCOM), were coupled to simulate waves and currents during Typhoon Fung-wong (2014) and Typhoon Chan-hom (2015) around the Zhoushan Islands. Both of these models employ the same unique unstructured grid. In particular, the influence of sea-surface currents, e.g., typhoon-induced and tidal currents, as well as the sea-water level, on wave simulation was studied. The composite wind field, which is derived from the parametric Holland model and European Centre for Medium-Range Weather Forecasts (ECMWF) winds (H-E winds), was taken as the forcing field. TPXO.5 tide data, sea-surface temperatures from the HYbrid Coordinate Ocean Model (HYCOM), HYCOM sea-surface salinity, and HYCOM sea-surface current were treated as open-boundary conditions. The comparison of sea-surface-current speed between the FVCOM simulation and the National Centers for Environmental Prediction (NCEP) Climate Forecast System Version 2 (CFSv2) data revealed a root-mean-square error (RMSE) of about 0.1206 m/s, with a correlation (Cor) more than 0.8, while the RMSE of the simulated sea-water level when compared with the HYCOM data was around 0.13 m, with a Cor of about 0.86. The validation indicated that the simulated results in this study were reliable. A sensitive experiment revealed that the sea-water level affected the typhoon-induced wave simulation. Validation against the measurements from the moored buoys showed an RMSE of

Cortical morphometry alterations in brain regions involved in emotional, motor-control and self-referential processing in patients with functional constipation - Chunxin Hu; Li Liu; Lei Liu; Junwang Zhang; Yang Hu; Wenchao Zhang; Yueyan Ding; Yuanyuan Wang; Zhida Zhang; Karen M. von Deneen; Long Qian; Huaning Wang; et al. (Brain Imaging and Behavior, 2020)

Effects of moss-dominated biocrusts on soil detachment by overland flow in the Three Gorges Reservoir Area of China - Guan-hua Zhang; Wen-feng Ding; Jian Pu; Jian-ming Li; Feng Qian; Bao-yang Sun (Journal of Mountain Science, 2020)

Eddy-resolving Simulation of CAS-LICOM3 for Phase 2 of the Ocean Model Intercomparison Project - Yiwen Li; Hailong Liu; Mengrong Ding; Pengfei Lin; Zipeng Yu; Yongqiang Yu; Yao Meng; Yunlong Li; Xiaodong Jian; Jinrong Jiang; Kangjun Chen; Qian Yang; et al. (Advances in Atmospheric Sciences, 2020)
A 61-year (1958–2018) global eddy-resolving dataset for phase 2 of the Ocean Model Intercomparison Project has been produced by the version 3 of Chinese Academy of Science, the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics/Institute of Atmospheric Physics (LASG/IAP) Climate system Ocean Model (CAS-LICOM3). The monthly and a part of the surface daily data in this study can be accessed on the Earth System Grid Federation (ESGF) node. Besides the details of the model and experiments, the evolutions and spatial patterns of large-scale and mesoscale features are also presented. The mesoscale features are reproduced well in the high-resolution simulation, as the mesoscale activities can contribute up to 50% of the total SST variability in eddy-rich regions. Also, the large-scale circulations are remarkably improved compared with the low-resolution simulation, such as the climatological annual mean SST (the RMSE is reduced from 0.59°C to 0.47°C, globally) and the evolution of Atlantic Meridional Overturning Circulation. The preliminary evaluation also indicates that there are systematic biases in the salinity, the separation location of the western boundary currents, and the magnitude of eddy kinetic energy. All these biases are worthy of further investigation.

FGOALS-g3 Model Datasets for CMIP6 Flux-Anomaly-Forced Model Intercomparison Project - Yaqi Wang; Zipeng Yu; Pengfei Lin; Hailong Liu; Jiangbo Jin; Lijuan Li; Yanli Tang; Li Dong; Kangjun Chen; Yiwen Li; Qian Yang; Mengrong Ding; et al. (Advances in Atmospheric Sciences, 2020)
The Flux-Anomaly-Forced Model Intercomparison Project (FAFMIP) is an endorsed Model Intercomparison Project in phase 6 of the Coupled Model Intercomparison Project (CMIP6). The goal of FAFMIP is to investigate the spread in the atmosphere-ocean general circulation model projections of ocean climate change forced by increased CO 2 , including the uncertainties in the simulations of ocean heat uptake, global mean sea level rise due to ocean thermal expansion and dynamic sea level change due to ocean circulation and density changes. The FAFMIP experiments have already been conducted with the Flexible Global Ocean-Atmosphere-Land System Model, gridpoint version 3.0 (FGOALS-g3). The model datasets have been submitted to the Earth System Grid Federation (ESGF) node. Here, the details of the experiments, the output variables and some baseline results are presented. Compared with the preliminary results of other models, the evolutions of global mean variables can be reproduced well by FGOALS-g3. The simulations of spatial patterns are also consistent with those of other models in most regions except the North Atlantic and the Southern Ocean, indicating large uncertainties in the regional sea level projections of these two regions.

Foliation Effects on Mechanical and Failure Characteristics of Slate in 3D Space Under Brazilian Test Conditions - Changdong Ding; Yang Zhang; Dawei Hu; Hui Zhou; Jianfu Shao (Rock Mechanics and Rock Engineering, 2020)

Antagonistic interactions between above- and belowground biota reduce their negative effects on a tree species - Qiang Yang; Arjen Biere; Jeffrey A. Harvey; Jianqing Ding; Evan Siemann (Plant and Soil, 2020)

Screening of optimal reference genes for qRT-PCR and preliminary exploration of cold resistance mechanisms in Prunus mume and Prunus sibirica varieties - Anqi Ding; Fei Bao; Tengxun Zhang; Weiru Yang; Jia Wang; Tangren Cheng; Qixiang Zhang (Molecular Biology Reports, 2020)

Silencing of LRP1 Exacerbates Inflammatory Response Via TLR4/NF-κB/MAPKs Signaling Pathways in APP/PS1 Transgenic Mice - Yingying He; John Bosco Ruganzu; Quzhao Zheng; Xiangyuan Wu; Hui Jin; Xiaoqian Peng; Bo Ding; Chengheng Lin; Shengfeng Ji; Yanbing Ma; Weina Yang (Molecular Neurobiology, 2020)

Occurrence and characteristics of iron-bearing minerals in surface road dusts: a case study in the coastal areas of southern Fujian, China - Dan Yang; Meina Wang; Jingchun Liu; Ting Deng; Chongling Yan; Zhenhua Ding; Haoliang Lu (Journal of Soils and Sediments, 2020)

Retraction Note: Assessing the influence of highway and high-speed railway construction on local climate using Landsat images in karst areas - Hua Zhou; Yang Luo; Fang-jun Ding; Qi-nan Lin (Journal of Mountain Science, 2020)

Good news: we can identify Ulva species erupted in the Yellow Sea more easily and cheaply now - Jinlin Liu; Xiaohui Zhao; Xinyu Kang; Minmin Zhuang; Xiaowei Ding; Lijuan Zhao; Qinlin Wen; Ying Zhu; Kai Gu; Qunjing Bao; Xiaoqian Yang; Jianheng Zhang; et al. (Conservation Genetics Resources, 2020)

Synthesis and antitumor activity of camptothecin- 4β-triazolopodophyllotoxin conjugates - Cheng-Ting Zi; Liu Yang; Fa-Wu Dong; Qing-Hua Kong; Zhong-Tao Ding; Jun Zhou; Zi-Hua Jiang; Jiang-Miao Hu (Natural Product Research, 2020)

Comprehensive analysis of miRNA-gene regulatory network with clinical significance in human cancers - Xiuliang Cui; Yang Liu; Wen Sun; Jin Ding; Xiaochen Bo; Hongyang Wang (Science China Life Sciences, 2020)

Exosomal HOTAIR promotes proliferation, migration and invasion of lung cancer by sponging miR-203 - Chengcheng Zhang; Lisha Xu; Guoying Deng; Yajie Ding; Ke Bi; Hansong Jin; Jixin Shu; Jia Yang; Haibin Deng; Zhongqi Wang; Yin Wang (Science China Life Sciences, 2020)

Atractylodes lancea volatiles induce physiological responses in neighboring peanut plant during intercropping - Xiaogang Li; Zhen Yang; Ya’nan Zhang; Li Yu; Changfeng Ding; Yangwenke Liao; Chuanchao Dai; Xingxiang Wang (Plant and Soil, 2020)

Predictive mechanics-based model for depth of cut (DOC) of waterjet in soft tissue for waterjet-assisted medical applications - Mahdieh Babaiasl; Stefano Boccelli; Yao Chen; Fan Yang; Jow-Lian Ding; John P. Swensen (Medical & Biological Engineering & Computing, 2020)

Insights into Dietary Switch in Cetaceans: Evidence from Molecular Evolution of Proteinases and Lipases - Guiting Li; Huiyuan Wei; Juanjuan Bi; Xiaoyue Ding; Lili Li; Shixia Xu; Guang Yang; Wenhua Ren (Journal of Molecular Evolution, 2020)

Privet golden leaves adapt unexpectedly well to light changes - Ming Yuan; Bo Huang; Li-Hua Dong; Qiao-Hong Han; Yong Yang; Chun-Bang Ding; Chao Hu; Yang-Er Chen; Zhong-Wei Zhang; Shu Yuan (Horticulture, Environment, and Biotechnology, 2020)

Socioeconomic factors of industrial air pollutants in Zhejiang Province, China: Decoupling and Decomposition analysis - Huihui Xia; Lei Ding; Shuwang Yang; Anping Wu (Environmental Science and Pollution Research, 2020)

Transcriptome Analysis of Two Strains of Proteus mirabilis with Swarming Migration Deficiency Isolated from Patients with Urinary Tract Infection - Liang Peng; Ding-Qiang Chen; Guan-Ming Jiang; Jing-Yi Ou; Qiao Jiang; Li-Ting Zeng; Yi Xiao; Qiong-Yan Jiang; Ling Yang; Ning Sun (Current Microbiology, 2020)

Comparing the Influence of High Doses of Different Zinc Salts on Oxidative Stress and Energy Depletion in IPEC-J2 Cells - Lingjun Chen; Xiaonan Yu; Haoxuan Ding; Yang Zhao; Caihong Hu; Jie Feng (Biological Trace Element Research, 2020)

Generation of mice with hepatocyte-specific conditional deletion of sphingosine kinase 1 - Jinfeng Yu; Jiale Dong; Kangdi Chen; Yaping Ding; Zhicheng Yang; Tian Lan (Transgenic Research, 2020)

Evolution of Palaeoenvironment of the South Yellow Sea Since the Last Deglaciation - Haoyin Wang; Guangxue Li; Yang Zhang; Yong Liu; Dongsheng Liu; Dong Ding; Jishang Xu; Yanyan Ma; Lulu Qiao; Liyan Wang; Qian Li (Journal of Ocean University of China, 2020)

Effects of light intensity on Opsin4 , Opsin5, and Pax6 expressions of the sea urchin Strongylocentrotus intermedius - Mingfang Yang; Yushi Yu; Jingyun Ding; Jia Luo; Jiangnan Sun; Fangyuan Hu; Yaqing Chang; Chong Zhao (Marine Ecology, 2020)
The detection of light intensity and subsequent phototaxis are essential for the fitness of sea urchins in intertidal and shallow subtidal waters, where light intensity varies in accordance with the depth and other hydrographic conditions. The molecular basis of photoresponse, however, remains largely unknown. We compared the expression of SiOpsin4 , SiPax6, and SiOpsin5 among tube feet, coelomocytes, gonads, and gut of the sea urchin Strongylocentrotus intermedius . All three genes showed the significantly highest expression in tube feet. To test whether r‐opsin genes (for example, Opsin4 ) and Pax6 in tube feet, rather than chaopsin genes (for example, Opsin5 ), are involved in the molecular responses to light intensity, we investigated the expression of Opsin4 , Pax6, and Opsin5 among four light intensities. Both Opsin4 and Pax6 expressions were significantly higher in the sea urchins at 1,500 lx than at 100, 300, and 700 lx, indicating a co‐upregulation of Opsin4 and Pax6 expressions in sea urchins exposed to the high light intensity (for example, 1,500 lx). However, there was no significant difference of SiOpsin5 expression among the four light intensity groups. Consistent with our hypothesis, there was no significant difference in either Opsin4 or Pax6 expression between the two light intensity environments (low light intensity environment: 50–100 lx; high light intensity environment: 330–1400 lx). This indicates that positive phototaxis and negative phototaxis probably regulate the expression of Opsin4 and Pax6 to a similar level when sea urchins are exposed to the high and low light intensities, respectively. The present study provides new insights into the molecular basis of light intensity detection and subsequent phototaxis of eyeless species.

Duration of SARS-CoV-2 viral shedding during COVID-19 infection - Guo-Qing Qian; Xue-Qin Chen; Ding-Feng Lv; Ada Hoi Yan Ma; Li-Ping Wang; Nai-Bin Yang; Xiao-Min Chen (Infectious Diseases, 2020)

A review of public and environmental consequences of organic germanium - Jiangfu Zheng; Lihua Yang; Yaocheng Deng; Chenyu Zhang; Yang Zhang; Sheng Xiong; Chunxia Ding; Jia Zhao; Chanjuan Liao; Daoxin Gong (Critical Reviews in Environmental Science and Technology, 2020)

An Experimental Study on Scale-Dependent Velocity and Anisotropy in Fractured Media Based on Artificial Rocks with Controlled Fracture Geometries - Pinbo Ding; Ding Wang; Xiang-Yang Li (Rock Mechanics and Rock Engineering, 2020)

Hydraulic Characteristics of Rough Joints Under Coupled Shear-Flow Conditions: An Experimental Study - Yang Gui; Caichu Xia; Wenqi Ding; Xin Qian; Shigui Du (Rock Mechanics and Rock Engineering, 2020)

Astrocytic GABAB Receptors in Mouse Hippocampus Control Responses to Behavioral Challenges through Astrocytic BDNF - Ji-Hong Liu; Ze-Lin Li; Yi-Si Liu; Huai-De Chu; Neng-Yuan Hu; Ding-Yu Wu; Lang Huang; Shu-Ji Li; Xiao-Wen Li; Jian-Ming Yang; Tian-Ming Gao (Neuroscience Bulletin, 2020)

Hepatitis B virus X protein promotes liver cell pyroptosis under oxidative stress through NLRP3 inflammasome activation - Wen-hui Xie; Jian Ding; Xiao-xia Xie; Xiao-huang Yang; Xiao-Fan Wu; Zhi-xin Chen; Qi-lan Guo; Wen-yu Gao; Xiao-zhong Wang; Dan Li (Inflammation Research, 2020)
Objective Hepatitis B virus X protein (HBx) is a pivotal factor for HBV-induced hepatitis. Herein, we sought to investigate HBx-mediated NLR pyrin domain containing 3 (NLRP3) inflammasome activation and pyroptosis under oxidative stress. Methods The effect of HBx on the NLRP3 inflammasome was analyzed by enzyme-linked immunosorbent assays, quantitative reverse transcription-polymerase chain reaction, western blotting, and immunofluorescence in hepatic HL7702 cells. Pyroptosis was evaluated by western blotting, lactate dehydrogenase release, propidium iodide staining, and transmission electron microscopy. NLRP3 expression in the inflammasome from liver tissues was assessed by immunohistochemistry. Results In hydrogen peroxide (H 2 O 2 )-stimulated HL7702 cells, HBx triggered the release of pro-inflammatory mediators apoptosis-associated speck-like protein containing a CARD (ASC), interleukin (IL)-1β, IL-18, and high-mobility group box 1 (HMGB1); activated NLRP3; and initiated pro-inflammatory cell death (pyroptosis). HBx localized to the mitochondria, where it induced mitochondrial damage and production of mitochondrial reactive oxygen species (mitoROS). Treatment of HL7702 cells with a mitoROS scavenger attenuated HBx-induced NLRP3 activation and pyroptosis. Expression levels of NLRP3, ASC, and IL-1β in liver tissues from patients were positively correlated with HBV DNA concentration. Conclusions The NLRP3 inflammasome was activated by elevated mitoROS levels and mediated HBx-induced liver inflammation and hepatocellular pyroptosis under H 2 O 2 -stress conditions.

Biosynthesis of the starch is improved by the supplement of nickel (Ni2+) in duckweed (Landoltia punctata) - Jin Shao; Zhibin Liu; Yongqiang Ding; Jianmei Wang; Xufeng Li; Yi Yang (Journal of Plant Research, 2020)

RETRACTED ARTICLE: CiRS-126 inhibits proliferation of ovarian granulosa cells through targeting the miR-21-PDCD4-ROS axis in a polycystic ovarian syndrome model - Jiafeng Lu; Ying Xue; Yuhang Wang; Yang Ding; Qinyan Zou; Min Pan; Longwei Qiao; Chunhua Zhang; Qinyu Ge; Ting Wang; Hong Li (Cell and Tissue Research, 2020)

AGA-SVR-based selection of feature subsets and optimization of parameter in regional soil salinization monitoring - Hongtao Xu; Chunbo Chen; Hongwei Zheng; Geping Luo; Liao Yang; Weisheng Wang; Shixin Wu; Jianli Ding (International Journal of Remote Sensing, 2020)

Genome-Wide Analysis of NAC Transcription Factors and Characterization of the Cold Stress Response in Sweet Osmanthus - Yuanzheng Yue; Ling Li; Yuli Li; Haiyan Li; Wenjie Ding; Tingting Shi; Gongwei Chen; Xiulian Yang; Lianggui Wang (Plant Molecular Biology Reporter, 2020)