Exploiting Sentinel-1 data and machine learning–based random forest for collectively mapping rice fields in Taiwan - Nguyen-Thanh Son; Chi-Farn Chen; Cheng-Ru Chen; Youg-Sin Cheng; Piero Toscano; Chein-Hui Syu; Horng-Yuh Guo; Shu-Ling Chen; Tsang-Sen Liu; Yi-Ting Zhang; Huan-Sheng Lin; Shih-Hsiang Chen; et al. (Applied Geomatics, 2022)

Community Competition Is the Microorganism Feedback to Sedimentary Carbon Degradation Process in Aquaculture Tidal Flats - Min Zhou; Fu-Tao Fang; Cong Zeng; Li-Hong Zhang; Cheng-Xu Zhou; Zhuo-Yi Zhu (Frontiers in Marine Science, 2022)
How the microbial community response to carbon degradation is unclear, while it plays an essential role in predicting microbial community shift and determining carbon cycling. Surface sediments in two contrasting aquacultural tidal flat sites in Fujian Province, China, were collected in October, 2020. In addition to 16s rRNA gene high-throughput sequencing for determining bacteria and archaea biodiversity, an amino acids-based molecular degradation index DI was used to quantify the carbon degradation status. The results revealed that the microorganism response to DI at the family level was community competition. Specifically, the winning microbes that grew under carbon degradation (i.e., operational taxa unit numbers negatively related with the degradation index) accounted for only 18% of the total family number, but accounted for 54% of the total operational taxa unit numbers. Network analysis confirmed the oppressive relation between winners and the rest (losers + centrists), and further suggested the losers survival strategy as uniting the centrists. These findings shed new light on microorganism feedback to carbon degradation, and provide a scientific basis for the explanation of microbial community shift under progressive carbon degradation.

Kuroshio Intrusion and Its Impact on Swordtip Squid (Uroteuthis edulis) Abundance in the Southern East China Sea - Yi-Chen Cheng; Sen Jan; Chung-Chi Chen (Frontiers in Marine Science, 2022)
Swordtip squid ( Uroteuthis edulis ) is a primary target species of the commercial fishery in the southern East China Sea (ECS), and they normally migrate to a quasi-permanent upwelling zone (called a cold dome) off northeastern Taiwan for spawning and growth during spring (March–May) and fall (October–December) in a year. We examined the connection of the variability in its standardized annual catch per unit effort (CPUE) during 2009–2017 in regard to the physical processes on the southern shelf of the ECS using temperature and wind observations from an isle north of Taiwan (Peng-jia-yu) as well as satellite sea surface temperature and absolute geostrophic velocity. The annual CPUE is positively correlated with the daily temperature anomaly at Peng-jia-yu in the cold dome in October of the previous year and April of the year. A warmer environment favors the recruitment and consequently the catch of the swordtip squid. During the spawning periods of the 9 years, the warm water carried by the Kuroshio frequently intruded atop the cold dome, which benefited the growth of the larvae and consequently helped maintain a certain value of the standardized annual CPUE. The anomalously low CPUE in 2012 and 2016 is attributed to the blocking of the Kuroshio intrusion due to cold and less salty China Coastal Water atop the cold dome in the spring spawning of 2012 and 2016. Based on the velocity strength in the cold dome and in a specified shelf region together with the daily temperature anomaly at Peng-jia-yu, an occupation intensity factor is used to evaluate the dominance of warm Kuroshio water and cold shelf water in the cold dome, which could help predict annual catches.

Cracking and Photo-Oxidation of Polyoxymethylene Degraded in Terrestrial and Simulated Marine Environments - Chih-Cheng Tang; Ying-Ting Chen; Yi-Ming Zhang; Huey-Ing Chen; Peter Brimblecombe; Chon-Lin Lee (Frontiers in Marine Science, 2022)
Marine plastic debris is an environmental problem, and its degradation into microplastics (1-5000 μm) introduces them into the food chain. In this study, small polyoxymethylene (global production ~3000 Tg per year) pellets were exposed in terrestrial and simulated marine environments to heat and light, resulting in cracking during decay with increasing IR absorption (OH-bonds). Furthermore, sunlight over three years reduced pellet mass and diameter (~10% and ~40%), initially yielding 100-300 μm fragments. Changes under UV irradiation were smaller as it could not penetrate into particle interiors. Characteristic spacing of surface striations (100-300 µm) initiated radial cracks to pellet interiors, and breakdown ultimately meant 95% of particles were <300 µm, which are potentially incorporated in marine turbidites.

A new highly oxygenated germacranolide from Carpesium nepalense var. lanatum (C.B.Clarke) Kitam - Yi-Fan Yu; Yue-Qian Li; Ru-Yue Wang; Xu Liu; Wen-Bo Cui; Xiao-Han Chen; Cheng-Mu Zhao; Feng-Ming Qi; Zhan-Xin Zhang; Dong-Qing Fei (Natural Product Research, 2022)

The Effects of Ground and Treadmill Running on Energy Metabolism and Muscle Contractile Properties: A Randomized Cross-Over Study - Yuan Zhou; Jian-gang Chen; Xiao-long Li; Xin-liang Pan; Yi-zheng Zhou; Zheng-ao Li; Zhi-cheng Liang; Jia-min Long; Ming-ze Qin; Jing Zhang; Bing Shi; Bing-jun Wan; et al. (Journal of Science in Sport and Exercise, 2022)
Purpose This study aimed to compare the effects of ground and treadmill running on energy metabolism and muscle contractile properties, providing a basis for the general public to choose running venues. Methods Ten male college students (age, 20.10 ± 1.53 years; height, 176.20 ± 5.49 cm; weight, 72.14 ± 8.25 kg; body fat percent, 12.41% ± 4.65%) were recruited in this study. Energy expenditure (EE) was measured using the accelerometer (GT9X) combined with specific estimation equations. Average heart rate (HR) was measured using a heart rate band (Polar). Muscle contractile properties were assessed by measuring muscle displacement (Dm) and contraction velocity (Vc) using tensiomyography (TMG-S1). Blood glucose (Glu) and lactate (Lac) were measured by portable devices (eB-G and Lactate Scout). The running speed was 9 km/h and the duration was 25 min. Two-way ANOVA (protocol × time) was used to analyze the effect of running protocols on energy metabolism and muscle contractile properties. Results EE of treadmill running was significantly higher than EE of ground running (protocol main effect, P < 0.001), and HR of treadmill running was significantly higher than that of ground running in the first testing time (protocol simple effect, P = 0.026; protocol × time interaction P = 0.043). The decrease in Dm of the rectus femoris after treadmill running was significantly higher than that of ground running (protocol main effect, P = 0.009). The interaction of different running protocols and testing times on Lac was significant ( P = 0.025), but all results of the simple effects analysis were not statistically significant ( P > 0.05). Conclusion Our study found a difference in energy expenditure between treadmill and ground running at 9 km/h with duration of 25 min. In addition, treadmills are more likely to cause a decrease in muscle displacement distance of the rectus femoris measured after exercise than ground running. Future studies are needed to further investigate whether the differences are induced by internal metabolism or the environmental conditions of running.

Identification of PDXDC1 as a novel pleiotropic susceptibility locus shared between lumbar spine bone mineral density and birth weight - Yu-Qian Song; Shi-Di Hu; Xu Lin; Xiang-He Meng; Xiao Wang; Yin-Hua Zhang; Cheng Peng; Rui Gong; Tao Xu; Tong Zhang; Chen-Zhong Li; Dao-Yan Pan; et al. (Journal of Molecular Medicine, 2022)
An increasing number of epidemiological studies have suggested that birth weight (BW) may be a determinant of bone health later in life, although the underlying genetic mechanism remains unclear. Here, we applied a pleiotropic conditional false discovery rate (cFDR) approach to the genome-wide association study (GWAS) summary statistics for lumbar spine bone mineral density (LS BMD) and BW, aiming to identify novel susceptibility variants shared between these two traits. We detected 5 novel potential pleiotropic loci which are located at or near 7 different genes ( NTAN1 , PDXDC1 , CACNA1G , JAG1 , FAT1P1 , CCDC170 , ESR1 ), among which PDXDC1 and FAT1P1 have not previously been linked to these phenotypes. To partially validate the findings, we demonstrated that the expression of PDXDC1 was dramatically reduced in ovariectomized (OVX) mice in comparison with sham-operated (SHAM) mice in both the growth plate and trabecula bone. Furthermore, immunohistochemistry assay with serial sections showed that both osteoclasts and osteoblasts express PDXDC1 , supporting its potential role in bone metabolism. In conclusion, our study provides insights into some shared genetic mechanisms for BMD and BW as well as a novel potential therapeutic target for the prevention of OP in the early stages of the disease development. Key messages We investigated pleiotropy-informed enrichment between LS BMD and BW. We identified genetic variants related to both LS BMD and BW by utilizing a cFDR approach. PDXDC1 is a novel pleiotropic gene which may be related to both LS BMD and BW. Elevated expression of PDXDC1 is related to higher BMD and lower ratio n-6/n-3 PUFA indicating a bone protective effect of PDXDC1.

Quantitative detection of parasitic ciliate Cryptocaryon irritans in seawater with an optimized sample processing method - Jia‐Jia Tang; Zhi‐Hong Zhong; Zhi‐Cheng Li; Qing‐Kai Guo; Shi‐Yu Li; Yi‐Xuan Guo; Biao Jiang; An‐Xing Li (Journal of Fish Diseases, 2022)
The protozoan Cryptocaryon irritans is one of the most important ectoparasites of marine fish, causing ‘white spot disease’ and mass mortality in aquaculture. To accurately predict disease outbreaks and develop prevention strategies, improved detection methods are required that are sensitive, convenient and rapid. In this study, a pair of specific primers based on the C . irritans 18S rRNA gene was developed and used in a real‐time PCR (qPCR) assay. This assay was able to detect five theronts in 1 L of natural seawater. Furthermore, a linear model was established to analyse the log of Ct value and parasite abundance in seawater (y = –2.9623x + 24.2930), and the coefficient of determination (R 2 ) value was 0.979. A lysis buffer was optimized for theront DNA extraction and used for storage sample. This method was superior to the commercial water DNA kit, and there was no significant degradation of DNA at room temperature for 24–96 hr. A dilution method was developed to manage qPCR inhibitors and used to investigate natural seawater samples in a net cage farm with diseased fish, and the findings were consistent with the actual situation. This study provides a valuable tool for assisting in the early monitoring and control of cryptocaryoniasis in aquaculture.

Chrysomutanin and related meroterpenoids from a DES mutant of the marine-derived fungus Penicillium chrysogenum S-3-25 - Hua Qiao; Shu-Hua Zhang; Yuan Dong; Yu Yang; Rui Xu; Bo Chen; Yi Wang; Tian-Jiao Zhu; Cheng-Bin Cui; Guo-Gang Zhang; Chang-Wei Li (Natural Product Research, 2022)

Flavonoid components and gene expression analysis reveal flower pigmentation difference between Magnolia biondii and its variety M. biondii var. purpurascens - Ning-hang Wang; Meng-yi Dai; Gang Zheng; Peng-jie Chang; Ling-juan Xuan; Zhi-gao Liu; Ya-ling Wang; Shao-yu Cheng; Zhuo-wei Wang; Hai-long Wang; Cui-hua Gu; Chao Zhang; et al. (Trees, 2022)

Quantifying effect of tassels on near-ground maize canopy RGB images using deep learning segmentation algorithm - Mingchao Shao; Chenwei Nie; Minghan Cheng; Xun Yu; Yi Bai; Bo Ming; Hongli Song; Xiuliang Jin (Precision Agriculture, 2022)

Subcellular localization and identification of acyl-CoA: lysophosphatidylethanolamine acyltransferase (LPEAT) in the arachidonic acid-rich green microalga, Myrmecia incisa Reisigl - Yi Liu; Hong Bao; Mei-Li Zhu; Cheng-Xi Hu; Zhi-Gang Zhou (Journal of Applied Phycology, 2022)

The significance of riparian communities in the energy flow of subtropical stream ecosystems - Yi-Chang Liao; An-Cheng Lin; Han-Ni Tsai; Yu-Ting Yen; Chyng-Shyan Tzeng; Man-Miao Yang; Hsing-Juh Lin (Aquatic Sciences, 2022)

Potent immunosuppressive and anti-inflammatory bisindole alkaloids from Melodinus fusiformis - Lu Liu; Ming-Jun Xie; Wen-Bing Zhou; Jin-Tang Wang; Jia-Yi Wang; Afsar Khan; Ya-Ping Liu; Jian-Xin Cao; Gui-Guang Cheng; Wen-Yuan Mao (Natural Product Research, 2022)

Wave Forces on a Partially Reflecting Wall by Oblique Bragg Scattering with Porous Breakwaters over Uneven Bottoms - Jen-Yi Chang; Chia-Cheng Tsai (Journal of Marine Science and Engineering, 2022)
In this study, the scattering of oblique water waves by multiple variable porous breakwaters near a partially reflecting wall over uneven bottoms are investigated using the eigenfunction matching method (EMM). In the solution procedure, the variable breakwaters and bottom profiles are sliced into shelves separated steps and the solutions on the shelves are composed of eigenfunctions with unknown coefficients representing the wave amplitudes. Using the conservations of mass and momentum as well as the condition for the partially reflecting sidewall, a system of linear equations is resulted that can be solved by a sparse-matrix solver. The proposed EMM is validated by comparing its results with those in the literature. Then, the EMM is applied for studying oblique Bragg scattering by periodic porous breakwaters near a partially reflecting wall over uneven bottoms. The constructive and destructive Bragg scattering are discussed. Numerical results suggest that the partially reflecting wall should be separated from the last breakwater by half wavelength of the periodic breakwaters to migrate the wave force on the vertical wall.

Synthesis and biological activity of amide derivatives derived from natural product Waltherione F - Hongbin Fang; Zhanfang Chen; Xuewen Hua; Wenrui Liu; Chenmeng Xue; Yi Liu; Xiaohe Zhu; Man Yuan; Shuang Cheng; Bingxiang Wang; Jing Ru; Dzmitry Bazhanau; et al. (Medicinal Chemistry Research, 2022)

Protease-Catalyzed Rational Synthesis of Uric Acid-Lowering Peptides in Non-aqueous Medium - Xiao-Ni Huang; Yan-Mei Zhang; You Wen; Yi Jiang; Cheng-Hua Wang (International Journal of Peptide Research and Therapeutics, 2022)

Effects of extreme precipitation on hospitalization risk and disease burden of schizophrenia in urban and rural Lu’an, China, from 2010 to 2019 - Yudong Wu; Zhenghai Yao; Gongyan Ma; Jian Cheng; Huabin Xu; Wei Qin; Weizhuo Yi; Rubing Pan; Qiannan Wei; Chao Tang; Xiangguo Liu; Yangyang He; et al. (Environmental Science and Pollution Research, 2022)

Correction to: Chitosan‑based hydrogels to treat hydrofluoric acid burns and prevent infection - Shu‑Wei Huang; Fang‑Ching Yeh; You‑Ren Ji; Ying‑Fu Su; Ying‑shih Su; Ming‑Hsien Chiang; Shian‑Chiuan Tzeng; Chien‑Yao Fu; Aristine Cheng; Yung‑Chih Wang; Yi‑Tzu Lee (Drug Delivery and Translational Research, 2022)

MoOpy2 is essential for fungal development, pathogenicity, and autophagy in Magnaporthe oryzae - Ying‐Ying Cai; Jing‐Yi Wang; Xi‐Yu Wu; Shuang Liang; Xue‐Ming Zhu; Lin Li; Jian‐Ping Lu; Xiao‐Hong Liu; Fu‐Cheng Lin (Environmental Microbiology, 2022)
Summary The development and pathogenicity of the fungus Magnaporthe oryzae , the causal agent of destructive rice blast disease, require it to perceive external environmental signals. Opy2, an overproduction‐induced pheromone‐resistant protein 2, is a crucial protein for sensing external signals in Saccharomyces cerevisiae . However, the biological functions of the homologue of Opy2 in M. oryzae are unclear. In this study, we identified that MoOPY2 is involved in fungal development, pathogenicity, and autophagy in M. oryzae . Deletion of MoOPY2 resulted in pleiotropic defects in hyphal growth, conidiation, germ tube extension, appressorium formation, appressorium turgor generation, and invasive growth, therefore leading to attenuated pathogenicity. Furthermore, MoOpy2 participates in the Osm1 MAPK pathway and the Mps1 MAPK pathway by interacting with the adaptor protein Mst50. The interaction sites of Mst50 and MoOpy2 colocalized with the autophagic marker protein MoAtg8 in the preautophagosomal structure sites (PAS). Notably, the Δ Moopy2 mutant caused cumulative MoAtg8 lipidation and rapid GFP‐MoAtg8 degradation in response to nitrogen starvation, showing that MoOpy2 is involved in the negative regulation of autophagy activity. Taken together, our study revealed that MoOpy2 of M. oryzae plays an essential role in the orchestration of fungal development, appressorium penetration, autophagy and pathogenesis.

Transcriptomic analysis of formic acid stress response in Saccharomyces cerevisiae - Lingjie Zeng; Jinxiang Huang; Pixue Feng; Xuemei Zhao; Zaiyong Si; Xiufeng Long; Qianwei Cheng; Yi Yi (World Journal of Microbiology and Biotechnology, 2022)

Galectin-1 Contributes to Vascular Remodeling and Blood Flow Recovery After Cerebral Ischemia in Mice - Yin-hong Cheng; Yi-fan Jiang; Chuan Qin; Ke Shang; Yuan Yuan; Xian-jie Wei; Zhe Xu; Xiang Luo; Wei Wang; Wen-sheng Qu (Translational Stroke Research, 2022)

L-Theanine Ameliorated Rotenone-Induced Parkinsonism-like Symptoms in Rats - Cheng-Neng Chen; Mao-Hsien Wang; Hung-Sheng Soung; Shu-Mei Chen; Chih-Hsiang Fang; Yi-Wen Lin; Hsiang-Chien Tseng (Neurotoxicity Research, 2022)

Microglial SIRPα Deletion Facilitates Synapse Loss in Preclinical Models of Neurodegeneration - Chongyun Wu; Luodan Yang; Hannah Youngblood; Timon Cheng-Yi Liu; Rui Duan (Neuroscience Bulletin, 2022)

Revealing the Precise Role of Calretinin Neurons in Epilepsy: We Are on the Way - Yingbei Qi; Heming Cheng; Yi Wang; Zhong Chen (Neuroscience Bulletin, 2022)

Dysregulated miR-29a-3p/PMP22 Modulates Schwann Cell Proliferation and Migration During Peripheral Nerve Regeneration - Yinying Shen; Zhangchun Cheng; Sailing Chen; Yunsong Zhang; Qi Chen; Sheng Yi (Molecular Neurobiology, 2022)

Common Subtype of Small Renal Mass MR Imaging Characterisation: A Medical Center Experience in Taiwan - Ming-Cheng Liu; Yi-Jui Liu; Yen-Ting Lin; Siu-Wan Hung; Jyh-Wen Chai; Si-Wa Chan; Kun-Yuan Chiu; Ya-Ling Tsou (Journal of Medical and Biological Engineering, 2022)
Purpose Many studies have shown that multiparametric magnetic resonance imaging (MRI) may be helpful for differentiating malignant renal cell carcinomas (RCCs) from benign lesions. However, the key imaging characteristics that differ between malignant and benign tumors still require further discussion. Methods We analyzed 60 adult patients diagnosed with 72 small renal masses (SRMs) who received preoperative MRI from 2014 to 2019 at a hospital in Taiwan. The MRI features included conventional MRI parameters, diffusion-weighted imaging (DWI) data, and dynamic contrast-enhanced (DCE) patterns, which were documented and compared among the four common subtypes: clear cell RCC (ccRCC), papillary RCC (pRCC), angiomyolipoma (AML) and other types of RCC. The apparent diffusion coefficient (ADC) values of high- and low-grade RCCs were also analyzed. Results The results show that ccRCC had higher T2-weighted signal intensity than the other three subgroups, a higher arterial wash-in index (AWI) and ADC value than AML and pRCC, and manifested a plateau ( n = 9, 25%) or washout (n = 27, 75%) enhancement pattern. AMLs exhibited more intravoxel fat than the other three subtype groups, and half of the AMLs (6 in 12) contained bulk fat. pRCC demonstrated a more progressive (n = 3, 60%) enhancement pattern than the other three subgroups. The ADC value of high-grade RCCs was significantly lower than that of low-grade RCCs. Conclusion These findings may indicate that multiparametric MRI is useful in differentiating among four common pathological types of SRMs, and the ADC value may be helpful in evaluating the histological grade of malignancy.

Impact of long-term tillage management on utilization of microbial carbon sources in rhizosphere and non-rhizosphere soils under a double-cropping rice paddy field - Kaikai Cheng; Haiming Tang; Chao Li; Wenguang Tang; Xiaoping Xiao; Zhenxie Yi (Environmental Science and Pollution Research, 2022)

Dissipation and residue of fosthiazate in tomato and cherry tomato and a risk assessment of dietary intake - Sukun Lin; Yi Zhou; Jiyingzi Wu; Zhixiang Zhang; Dongmei Cheng (Environmental Science and Pollution Research, 2022)

A Hydroponic Study on Effect of Zinc Against Mercury Uptake by Triticale: Kinetic Process and Accumulation - Ting Liu; Yi Man; Ping Li; Hua Zhang; Huangxin Cheng (Bulletin of Environmental Contamination and Toxicology, 2022)

miRNA–mRNA Integrative Analysis Reveals the Roles of miRNAs in Hypoxia-Altered Embryonic Development- and Sex Determination-Related Genes of Medaka Fish - Keng Po Lai; Nathan Yi Kan Tam; Yuelong Chen; Chi Tim Leung; Xiao Lin; Chau Fong Tsang; Yin Cheung Kwok; William Ka Fai Tse; Shuk Han Cheng; Ting Fung Chan; Richard Yuen Chong Kong (Frontiers in Marine Science, 2022)
Recent studies have shown hypoxia to be an endocrine disruptor that impairs sex differentiation and reproductive function, leading to male-biased F1 populations in fish. However, the molecular mechanisms through which hypoxia alters fish sex differentiation and therefore sex ratios remain poorly understood. In order to understand the potential role of miRNAs in mediating hypoxia-altered sex determination and differentiation in fish, we conducted small RNA sequencing and transcriptome sequencing on marine medaka ( Oryzias melastigma ) embryos that were exposed to hypoxia (2.0 ± 0.2 mg O 2 L – 1) for 40 h (encompassing a critical window of sex determination). We identified dysregulated miRNAs and mRNAs in the hypoxia-exposed embryo, and bioinformatic analysis of the integrative small RNA sequencing and transcriptome sequencing results revealed hypoxia to cause alterations of genes related to embryonic development through miRNA regulation. Importantly, we have identified miRNA-mRNA pairs that were reported to play roles in gonad development (novel miR-145-col9a3 and novel miRNA-94- arid5b), in sex hormone response (novel miRNA-210-ca2, novel miRNA-106-nr2f2, nbr-miR-29c-nr4a1, and ola-miR-92b-akr1d1), and in sex characteristic development (novel miRNA-145-mns1, nle-miR-20-sord, and ipu-miR-219b-abcc8). Our findings highlighted the possible roles of miRNA–mRNA in regulation of embryonic development and sex determination in response to hypoxic stress.

Identifying Priority Conservation Areas of Largehead Hairtail (Trichiurus japonicus) Nursery Grounds in the East China Sea - Zunlei Liu; Yan Jin; Liping Yan; Yi Zhang; Hui Zhang; Chuyi Shen; Linlin Yang; Jiahua Cheng (Frontiers in Marine Science, 2022)
Identifying the spatio-temporal distribution hotspots of fishes and allocating priority conservation areas could facilitate the spatial planning and efficient management. As a flagship commercial fishery species, Largehead hairtail ( Trichiurus japonicus ) has been over-exploited since the early 2000s. Therefore, the spatio-temporal management of largehead hairtail nursery grounds could effective help its recovery. This study aims to predict juvenile largehead hairtail distribution patterns and identify priority conservation areas for nursery grounds. A two-stage hierarchical Bayesian spatio-temporal model was applied on independent scientific survey data (Catch per unit effort, CPUE) and geographic/physical variables (Depth, Distance to the coast, Sea bottom temperature, Dissolved oxygen concentration and Net primary production) to analyze the probability of occurrence and abundance distribution of juvenile largehead hairtail. We assessed the importance of each variable for explaining the occurrence and abundance. Using persistence index, we measured the robustness of hotspots and identified persistent hotspots for priority conservation areas. Selected models showed good predictive capacity on occurrence probability (AUC = 0.81) and abundance distribution ( r = 0.89) of juvenile largehead hairtail. Dissolved oxygen, net primary production, and sea bottom temperature significantly affected the probability of occurrence, while distance to the coast also affected the abundance distribution. Three stable nursery grounds were identified in Zhejiang inshore waters, the largest one was located on the east margin of the East China Sea hairtail national aquatic germplasm resources conservation zones (TCZ), suggesting that the core area of nursery grounds occurs outside the protected areas. Therefore, recognition of these sites and their associated geographic/oceanic attributes provides clear targets for optimizing largehead hairtail conservation efforts in the East China Sea. We suggested that the eastern and southern areas of TCZ should be included in conservation planning for an effective management within a network of marine protected areas.

Distribution of Coomassie Blue Stainable Particles in the Pearl River Estuary, China, Insight Into the Nitrogen Cycling in Estuarine System - Cui-Ci Sun; Wei-Zhong Yue; You-Shao Wang; Wei-Hong He; Yi-Guo Hong; Fu-Lin Sun; Hao Cheng; Mei-Lin Wu; Zhao-Yu Jiang; Fei Jiao; Yu-Tu Wang (Frontiers in Marine Science, 2022)
Distributions of Coomassie Blue stainable particles (CSP), the sources and transports, as well as their implications for nitrogen biogeochemical cycles in the Pearl River estuary (PRE) were investigated during two cruises in August 2016 and January 2017. CSP color concentrations (CSP concentration determined spectrophotometrically) were 73.7–685.3 μg BSA eq L –1 [μg Bovine serum albumin (BSA) equivalent liter –1 ] in August 2016 and 100.6–396.4 μg BSA eq L –1 in January 2017, respectively. CSP concentrations were high in low-salinity waters (<5), and declined from the river to the middle estuary by 80% in the wet season and 55.6% in the dry season, respectively, then increased again in the lower estuary due to high primary production. CSP concentrations were mainly associated with chlorophyll a (Chl a ) concentration except for the turbid mixing zone, suggesting that autochthonous phytoplankton production served as the primary source of CSP in the PRE. The concentrations of nitrogen (N) as CSP in the PRE were comparable to the nitrogen content of particulate hydrolysable amino acids (PHAA). Pictures of CSP taken by microscopy and the correlation between composition of PHAA and the ratio of Chl a /CSP color showed that CSP were relatively degraded due to delivery of old terrestrial protein to river section and extensive microbial degradation during mixing at the upper and middle parts of the estuary, whereas CSP in lower estuary appeared to be more labile due to higher fresh algal production. The contribution of CSP nitrogen (CSP-N) to the particulate nitrogen (PN) pool was 34.98% in summer and 30.8% in winter. The conservative estimate of CSP-N input flux in the Pearl River Delta was about 6 × 10 6 mol N d –1 . These results suggested that CSP was a significant pool of organic nitrogen in the PRE. The study of CSP composition in terms of nitrogen provides new insight into the roles of CSP on nitrogen biogeochemical processes in the turbid and productive estuarine system.

Joint Inversion and Application of DC and Full-Domain TEM with Particle Swarm Optimization - Yi Dong; Jiulong Cheng; Haijun Xie; Fei Li; Junjie Xue; Laifu Wen; Zhi Chen; Junjun Jiao (Pure and Applied Geophysics, 2022)

Association of Increased Amygdala Activity with Stress-Induced Anxiety but not Social Avoidance Behavior in Mice - Shou-He Huang; Wei-Zhu Liu; Xia Qin; Chen-Yi Guo; Qing-Cheng Xiong; Yu Wang; Ping Hu; Bing-Xing Pan; Wen-Hua Zhang (Neuroscience Bulletin, 2022)

Flood vulnerability assessment using the triangular fuzzy number-based analytic hierarchy process and support vector machine model for the Belt and Road region - Yu Duan; Junnan Xiong; Weiming Cheng; Nan Wang; Yi Li; Yufeng He; Jun Liu; Wen He; Gang Yang (Natural Hazards, 2022)

The phenolic acids from Oplopanax elatus Nakai stems and their potential photo-damage prevention activity - Yu Han; Dongsheng Cheng; Mimi Hao; Jiejing Yan; Jingya Ruan; Lifeng Han; Yi Zhang; Tao Wang (Journal of Natural Medicines, 2022)

Effects of pH values and application methods of potassium silicate on nutrient uptake and bacterial spot of tomato - Yi-Chun Chien; Cheng-Hua Huang (European Journal of Plant Pathology, 2022)

Temporal trends of the association between temperature variation and hospitalizations for schizophrenia in Hefei, China from 2005 to 2019: a time-varying distribution lag nonlinear model - Rubing Pan; Zhenhai Yao; Weizhuo Yi; Qiannan Wei; Yangyang He; Chao Tang; Xiangguo Liu; Shasha Son; Yanhu Ji; Jian Song; Jian Cheng; Yifu Ji; et al. (Environmental Science and Pollution Research, 2022)

Impact of diabetes and modifiable risk factors on pancreatic cancer survival in a population-based study after adjusting for clinical factors - Mei-Chin Hsieh; Lu Zhang; Cruz Velasco-Gonzalez; Yong Yi; Lisa A. Pareti; Edward J. Trapido; Vivien W. Chen; Xiao-Cheng Wu (Cancer Causes & Control, 2022)

Probing the Functional and Structural Connectivity Underlying EEG Traveling Waves - Yun Qin; Nan Zhang; Yan Chen; Yue Tan; Zhenglin Yang; Yi Shi; Cheng Luo; Tiejun Liu; Dezhong Yao (Brain Topography, 2022)

Isolation and partial characterization of a novel bacteriocin from Pseudomonas azotoformans with antimicrobial activity against Pasterella multocida - Yu Wang; Shuang Lei; Inam Muhammad; Yu Jia; Cheng-guang He; Yi-Ming Wang; Yun-Hang Gao; Ling-Cong Kong; Hong-Xia Ma (Archives of Microbiology, 2022)

Nakamurella leprariae sp. nov., isolated from a lichen sample - De-Feng An; Shao-Juan Yang; Long-Qian Jiang; Xin-Yu Wang; Xiao-Yu Huang; Lei Lang; Xue-Mei Chen; Ming-Qun Fan; Gui-Ding Li; Ming-Guo Jiang; Li-Song Wang; Cheng-Lin Jiang; et al. (Archives of Microbiology, 2022)

Cytotoxic activity of phytochemicals from Garcinia mangostana L. and G. benthamiana (Planch. & Triana) Pipoly against breast cancer cells - Irene See; Gwendoline Cheng Lian Ee; Vivien Yi Mian Jong; Soek Sin Teh; Carlos L. Céspedes Acuña; Siau Hui Mah (Natural Product Research, 2021)

Cytotoxicity and nitric oxide inhibitory activities of Xanthones isolated from Calophyllum hosei Ridl. - Shaari Daud; Thiruventhan Karunakaran; Rameshkumar Santhanam; Suman Raj Nagaratnam; Vivien Yi Mian Jong; Gwendoline Cheng Lian Ee (Natural Product Research, 2021)

Neonatal Anesthesia by Ketamine in Neonatal Rats Inhibits the Proliferation and Differentiation of Hippocampal Neural Stem Cells and Decreases Neurocognitive Function in Adulthood via Inhibition of the Notch1 Signaling Pathway - He Huang; Chao Zhao; Qian Hu; Qiang Liu; Yi-Man Sun; Chen Chen; Hui Huang; Cheng-Hua Zhou; Yu-Qing Wu (Molecular Neurobiology, 2021)

Failure mechanism and kinematics of the Tonghua landslide based on multidisciplinary pre- and post-failure data - Qiang Cheng; Yinghui Yang; Yi Du (Landslides, 2021)

Effects of different heat exposure patterns (accumulated and transient) and schizophrenia hospitalizations: a time-series analysis on hourly temperature basis - Chao Tang; Yifu Ji; Qingru Li; Zhenhai Yao; Jian Cheng; Yangyang He; Xiangguo Liu; Rubing Pan; Qiannan Wei; Weizhuo Yi; Hong Su (Environmental Science and Pollution Research, 2021)

Evaluation of life expectancy loss associated with submicron and fine particulate matter (PM1 and PM2.5) air pollution in Nanjing, China - Hao Zheng; Weizhuo Yi; Zhen Ding; Zhiwei Xu; Hung Chak Ho; Jian Cheng; Mohammad Zahid Hossain; Jian Song; Yinguang Fan; Jing Ni; Qingqing Wang; Yan Xu; et al. (Environmental Science and Pollution Research, 2021)

Does the smart city policy promote the green growth of the urban economy? Evidence from China - Yu Qian; Jun Liu; Zhonghua Cheng; Jeffrey Yi-Lin Forrest (Environmental Science and Pollution Research, 2021)

The r-X1 deletion induces terminal deficiencies in the maize B chromosome - Yen-Hua Huang; Tzu-Che Lin; Wan-Yi Chiou; Ya-Ming Cheng (Chromosome Research, 2021)

Correction to: 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Bernard R. Agwanda; Rim Al Kubrusli; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Christopher F. Basler; et al. (Archives of Virology, 2021)

2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Bernard R. Agwanda; Rim Al Kubrusli; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Christopher F. Basler; et al. (Archives of Virology, 2021)

Active earth pressure against inclined rigid retaining wall considering rotation of principal stresses under translation mode - Cai-Song Luo; Peng-Zhi Yang; Cheng Dong; Pei-Cheng Zhang; Yi-Tao Zhou (Arabian Journal of Geosciences, 2021)

Global gross nitrification rates are dominantly driven by soil carbon‐to‐nitrogen stoichiometry and total nitrogen - Ahmed S. Elrys; Jing Wang; Mohamed A. S. Metwally; Yi Cheng; Jin‐Bo Zhang; Zu‐Cong Cai; Scott X. Chang; Christoph Müller (Global Change Biology, 2021)
Soil gross nitrification (GN) is a critical process in the global nitrogen (N) cycle that results in the formation of nitrate through microbial oxidation of ammonium or organic N, and can both increase N availability to plants and nitrous oxide emissions. Soil GN is thought to be mainly controlled by soil characteristics and the climate, but a comprehensive analysis taking into account the climate, soil characteristics, including microbial characteristics, and their interactions to better understand the direct and indirect controlling factors of GN rates globally is lacking. Using a global meta‐analysis based on 901 observations from 330 15 N‐labeled studies, we show that GN differs significantly among ecosystem types, with the highest rates found in croplands, in association with higher pH which stimulates nitrifying bacteria activities. Autotrophic and heterotrophic nitrifications contribute 63% and 37%, respectively, to global GN. Soil GN increases significantly with soil total N, microbial biomass, and soil pH, but decreases significantly with soil carbon (C) to N ratio (C:N). Structural equation modeling suggested that GN is mainly controlled by C:N and soil total N. Microbial biomass and pH are also important factors controlling GN and their effects are similar. Precipitation and temperature affect GN by altering C:N and/or soil total N. Soil total N and temperature drive heterotrophic nitrification, whereas C:N and pH drive autotrophic nitrification. Moreover, GN is positively related to nitrous oxide and carbon dioxide emissions. This synthesis suggests that changes in soil C:N, soil total N, microbial population size, and/or soil pH due to anthropogenic activities may influence GN, which will affect nitrate accumulation and gaseous emissions of soils under global climate and land‐use changes.

Study of Heavy Metals and Microbial Communities in Contaminated Sediments Along an Urban Estuary - Jun Yi; Linus Shing Him Lo; Hongbin Liu; Pei-Yuan Qian; Jinping Cheng (Frontiers in Marine Science, 2021)
Estuarine sediments are increasingly contaminated by heavy metals as a result of urbanization and human activities. Continuous multi-heavy metal accumulation in the ecosystem can provoke new effects on top of the complex environmental interactions already present in estuarine ecosystems. It is important to study their integrated influence on imperative microbial communities to reflect on the environmental and ecological risks they may impose. Inductively coupled plasma optical emission spectroscopy analysis for five metals Cd, Cr, Cu, Pb, and Zn showed that Cr and Cu concentrations in intertidal sediments of the urbanized Yangtze River estuary in China have consistently exceeded respective threshold effect concentration (TEC) levels. The geo-accumulation and potential ecological risk index results of the five metals showed that all sampling sites were weakly to moderately polluted, and at considerable to high ecological risk, respectively. Redundancy and correlation analyses showed that Zn followed by Cr in the ecosystem were explanatory of the shifts in recorded microbial community structures. However, the spatial variation in metal concentrations did not correspond to the selection of metal resistance genes (MRGs). Unlike many other dominant bacterial taxa, most of the sulfate-reducing bacteria (SRB) and associated sulfate respiration as the dominant microbially contributed ecological function were found to negatively correlate with Zn and total heavy metal pollution. Zn concentration was proposed to be a potent indicator for heavy metal pollution-associated microbial community compositional shifts under urbanized estuarine conditions. The associations between heavy metals and estuarine microbial communities in this study demonstrate the influence of heavy metals on microbial community structure and adaptations that is often overshadowed by environmental factors (i.e., salinity and nutrients).

The Eyes Have It: Perception of Social Interaction Unfolds Through Pupil Dilation - Yuhui Cheng; Wenjie Liu; Xiangyong Yuan; Yi Jiang (Neuroscience Bulletin, 2021)

Paternal exposure to microcystin-LR induces fetal growth restriction partially through inhibiting cell proliferation and vascular development in placental labyrinth - Lan Gao; An-Qi Cui; Jing Wang; Jing Chen; Xiao-Yi Zhang; Zhi-Jing Lin; Yuan-Hua Chen; Cheng Zhang; Hua Wang; De-Xiang Xu (Environmental Science and Pollution Research, 2021)

Research on the innovation incentive effect and heterogeneity of the market-incentive environmental regulation on mineral resource enterprises - Yi Wei; Deyi Xu; Kangkang Zhang; Jinhua Cheng (Environmental Science and Pollution Research, 2021)

The effect of the PARK16 rs11240572 variant on brain structure in Parkinson's disease - Lu-yan Gu; Shao-bing Dai; Cheng Zhou; Ting Gao; Jing-jing Wu; Yi Fang; Xiao-jun Guan; Tao Guo; Ran Zheng; Chongyao Jin; Xiao-jun Xu; Zhe Song; et al. (Brain Structure and Function, 2021)

A prediction model of coal structure based on logging parameters in Liupanshui Coalfield, Guizhou, China - Fang Lv; ·Ruidong Yang; ·Tongsheng Yi; Wei Gao; ·Wei Cheng; ·Zhihua Yan (Arabian Journal of Geosciences, 2021)

Divergence in the Aquilegia ecalcarata complex is correlated with geography and climate oscillations: Evidence from plastid genome data - Cheng Xue; Fang‐Dong Geng; Jiao‐Jie Li; Dan‐Qing Zhang; Fei Gao; Lei Huang; Xiao‐Hui Zhang; Ju‐Qing Kang; Jian‐Qiang Zhang; Yi Ren (Molecular Ecology, 2021)
Quaternary climate oscillations and geographical heterogeneity play important roles in determining species and genetic diversity distribution patterns, but how these factors affect the migration and differentiation of East Asian plants species at the population level remains poorly understood. The Aquilegia ecalcarata complex, a group that originated in the Late Tertiary and is widely distributed throughout East Asia, displays high genetic variation that is suitable for studying elaborate phylogeographic patterns and demographic history related to the impact of Quaternary climate and geography. We used plastid genome data from 322 individuals in 60 populations of the A . ecalcarata complex to thoroughly explore the impact of Quaternary climate oscillations and geography on the phylogeographic patterns and demographic history of the A . ecalcarata complex through a series of phylogenetic, divergence time estimation, and demographic history analyses. The dry, cold climate and frequent climate oscillations that occurred during the early Pleistocene and the Mid‐Pleistocene transition led to the differentiation of the A . ecalcarata complex, which was isolated in various areas. Geographically, the A . ecalcarata complex can be divided into Eastern and Western Clades and five subclades, which conform to the divergence of the East Asian flora. Our results clearly show the impact of Quaternary climate and geography on evolutionary history at the population level. These findings promote the understanding of the relationship between plant genetic differentiation and climate and geographical factors of East Asia at the population level.

Patterns and drivers of global gross nitrogen mineralization in soils - Ahmed S. Elrys; Ahmad Ali; Huimin Zhang; Yi Cheng; Jinbo Zhang; Zu‐Cong Cai; Christoph Müller; Scott X. Chang (Global Change Biology, 2021)
Soil gross nitrogen (N) mineralization (GNM), a key microbial process in the global N cycle, is mainly controlled by climate and soil properties. This study provides for the first time a comprehensive analysis of the role of soil physicochemical properties and climate and their interactions with soil microbial biomass (MB) in controlling GNM globally. Through a meta‐analysis of 970 observations from 337 published papers from various ecosystems, we found that GNM was positively correlated with MB, total carbon, total N and precipitation, and negatively correlated with bulk density (BD) and soil pH. Our multivariate analysis and structural equation modeling revealed that GNM is driven by MB and dominantly influenced by BD and precipitation. The higher total N accelerates GNM via increasing MB. The decrease in BD stimulates GNM via increasing total N and MB, whereas higher precipitation stimulates GNM via increasing total N. Moreover, the GNM varies with ecosystem type, being greater in forests and grasslands with high total carbon and MB contents and low BD and pH compared to croplands. The highest GNM was observed in tropical wet soils that receive high precipitation, which increases the supply of soil substrate (total N) to microbes. Our findings suggest that anthropogenic activities that affect soil microbial population size, BD, soil substrate availability, or soil pH may interact with changes in precipitation regime and land use to influence GNM, which may ultimately affect ecosystem productivity and N loss to the environment.

Implantation of Bone Marrow Mesenchymal Stem Cells into Small Intestinal Submucosa Improves Bile Duct Injury in Rabbits - Ying Li; Piao Wang; Xiao-dong Hu; Jing-da Zeng; Cheng Fang; Yu Gan; Fang-yi Peng; Xiao-li Yang; De Luo; Bo Li; Song Su (Tissue Engineering and Regenerative Medicine, 2021)

Indication of paleoecological evidence on the evolution of alpine vegetation productivity and soil erosion in central China since the mid-Holocene - Ying Cheng; Hongyan Liu; Hongya Wang; Deliang Chen; Philippe Ciais; Yao Luo; Xiuchen Wu; Yi Yin (Science China Earth Sciences, 2021)

Qingbo, a common cyprinid fish, responds diversely in behavior and locomotion to predators with different hunting modes - Cheng Fu; Lian-Chun Yi; Wen-Pei Wu; Chun-Xiao Sun; Rui-Na Liu; Shi-Jian Fu (Fish Physiology and Biochemistry, 2021)

The Protective Role of the Long Pentraxin PTX3 in Spontaneously Hypertensive Rats with Heart Failure - Wei Chen; Ya-Se Zhuang; Chun-Xia Yang; Zhi-Cheng Fang; Bo-Yi Liu; Xiang Zheng; Ying-Ying Liao (Cardiovascular Toxicology, 2021)

Functional connectivity patterns of the subgenual anterior cingulate cortex in first-episode refractory major depressive disorder - Bochao Cheng; Yajing Meng; Yan Zuo; Yi Guo; Xiuli Wang; Song Wang; Ran Zhang; Wei Deng; Yingkun Guo; Gang Ning (Brain Imaging and Behavior, 2021)

A new IMU-aided multiple GNSS fault detection and exclusion algorithm for integrated navigation in urban environments - Rui Sun; Junhui Wang; Qi Cheng; Yi Mao; Washington Yotto Ochieng (GPS Solutions, 2021)

Effects of Fatigue on Inter-joint Coordination in Ballet Dancers During a Ballet Jumping Movement (petit échappé sauté) - Chai-Wei Lin; Jeng-Feng Yang; Yi-An Chen; Cheng-Feng Lin (Journal of Medical and Biological Engineering, 2021)

Experimental study on integrated and autonomous conductivity-temperature-depth (CTD) sensor applied for underwater glider - Bin Lv; Hai-lin Liu; Yi-fan Hu; Cheng-xuan Wu; Jie Liu; Hai-jing He; Jie Chen; Jian Yuan; Zhao-wen Zhang; Lin Cao; Hui Li (Marine Georesources & Geotechnology, 2021)

Correction to: Chemical Speciation and Interaction Mechanism of U in “Shewanella putrefaciens-Mineral-U” System - J. Gao; W. Yuan; J. Cheng; J. Zhang; S. Feng; F. Huang; F. Yi; H. Huang; H. Zhang (Water, Air, & Soil Pollution, 2021)

BnA1.CER4 and BnC1.CER4 are redundantly involved in branched primary alcohols in the cuticle wax of Brassica napus - Jie Liu; Lixia Zhu; Benqi Wang; Huadong Wang; Imran khan; Shuqin Zhang; Jing Wen; Chaozhi Ma; Cheng Dai; Jinxing Tu; Jinxiong Shen; Bin Yi; et al. (Theoretical and Applied Genetics, 2021)

Association between large artery stenosis, cerebral small vessel disease and risk of ischemic stroke - Fei Han; Ding-Ding Zhang; Fei-Fei Zhai; Jun Xue; Jiang-Tao Zhang; Shuang Yan; Li-Xin Zhou; Jun Ni; Ming Yao; Meng Yang; Ming-Li Li; Zheng-Yu Jin; et al. (Science China Life Sciences, 2021)

Applying Artificial Intelligence (AI) Techniques to Implement a Practical Smart Cage Aquaculture Management System - Chung-Cheng Chang; Jung-Hua Wang; Jenq-Lang Wu; Yi-Zeng Hsieh; Tzong-Dar Wu; Shyi-Chy Cheng; Chin-Chun Chang; Jih-Gau Juang; Chyng-Hwa Liou; Te-Hua Hsu; Yii-Shing Huang; Cheng-Ting Huang; et al. (Journal of Medical and Biological Engineering, 2021)
Purpose This paper presents our team’s results to establish an AIoT smart cage culture management system. Methods According to the built system, the farmed field information is transmitted to the data platform of Ocean Cloud, and all collected data and analysis results can be applied to the cage culture field after the bigdata analysis. Results This management system successfully integrates AI and IoT technologies and is applied in cage culture. Using underwater biological analysis images and AI feeding as examples, this paper explains how the system integrates AI and IoT into a feasible framework that can constantly acquire information about the health status of fish, survival rate of fish, as well as the feed residuals. Conclusion The results of our research enable the aquaculture operators or owners to efficiently reduce the feed residual, monitor the growth of fish, and increase fish survival rate, thereby increasing the feed conversion rate.

Complex analysis of the personalized pharmacotherapy in the management of COVID-19 patients and suggestions for applications of predictive, preventive, and personalized medicine attitude - Lei-Yun Wang; Jia-Jia Cui; Qian-Ying OuYang; Yan Zhan; Yi-Min Wang; Xiang-Yang Xu; Lu-Lu Yu; Hui Yin; Yang Wang; Chen-Hui Luo; Cheng-Xian Guo; Ji-Ye Yin (EPMA Journal, 2021)
Aims Coronavirus disease 2019 (COVID-19) is rapidly spreading worldwide. Drug therapy is one of the major treatments, but contradictory results of clinical trials have been reported among different individuals. Furthermore, comprehensive analysis of personalized pharmacotherapy is still lacking. In this study, analyses were performed on 47 well-characterized COVID-19 drugs used in the personalized treatment of COVID-19. Methods Clinical trials with published results of drugs use for COVID-19 treatment were collected to evaluate drug efficacy. Drug-to-Drug Interactions (DDIs) were summarized and classified. Functional variations in actionable pharmacogenes were collected and systematically analysed. “Gene Score” and “Drug Score” were defined and calculated to systematically analyse ethnicity-based genetic differences, which are important for the safer use of COVID-19 drugs. Results Our results indicated that four antiviral agents (ritonavir, darunavir, daclatasvir and sofosbuvir) and three immune regulators (budesonide, colchicine and prednisone) as well as heparin and enalapril could generate the highest number of DDIs with common concomitantly utilized drugs. Eight drugs (ritonavir, daclatasvir, sofosbuvir, ribavirin, interferon alpha-2b, chloroquine, hydroxychloroquine (HCQ) and ceftriaxone had actionable pharmacogenomics (PGx) biomarkers among all ethnic groups. Fourteen drugs (ritonavir, daclatasvir, prednisone, dexamethasone, ribavirin, HCQ, ceftriaxone, zinc, interferon beta-1a, remdesivir, levofloxacin, lopinavir, human immunoglobulin G and losartan) showed significantly different pharmacogenomic characteristics in relation to the ethnic origin of the patient. Conclusion We recommend that particularly for patients with comorbidities to avoid serious DDIs, the predictive, preventive, and personalized medicine (PPPM, 3 PM) strategies have to be applied for COVID-19 treatment, and genetic tests should be performed for drugs with actionable pharmacogenes, especially in some ethnic groups with a higher frequency of functional variations, as our analysis showed. We also suggest that drugs associated with higher ethnic genetic differences should be given priority in future pharmacogenetic studies for COVID-19 management. To facilitate translation of our results into clinical practice, an approach conform with PPPM/3 PM principles was suggested. In summary, the proposed PPPM/3 PM attitude should be obligatory considered for the overall COVID-19 management.

Combined effect of nanoscale zero-valent iron and linear alkylbenzene sulfonate (LAS) to the freshwater algae Scenedesmus obliquus - Rong Cheng; Ya-ping Liu; Yi-hui Chen; Liang-jie Shen; Jiao-jiao Wu; Lei Shi; Xiang Zheng (Ecotoxicology, 2021)

Viable and Heat-Killed Probiotic Strains Improve Oral Immunity by Elevating the IgA Concentration in the Oral Mucosa - Wen-Yang Lin; Yi-Wei Kuo; Ching-Wei Chen; Yu-Fen Huang; Chen-Hung Hsu; Jia-Hung Lin; Cheng-Ruei Liu; Jui-Fen Chen; Ko-Chiang Hsia; Hsieh-Hsun Ho (Current Microbiology, 2021)
Oral-nasal mucosal immunity plays a crucial role in protecting the body against bacterial and viral invasion. Safe probiotic products have been used to enhance human immunity and oral health. In this study, we verified the beneficial effects of mixed viable probiotic tablets, consisting of Lactobacillus salivarius subsp. salicinius AP-32, Bifidobacterium animalis subsp. lactis CP-9, and Lactobacillus paracasei ET-66, and heat-killed probiotic tablets, consisting of L. salivarius subsp. salicinius AP-32 and L. paracasei ET-66, on oral immunity among 45 healthy participants. Participants were randomly divided into viable probiotic, heat-killed probiotic, and placebo groups. The administration of treatment lasted for 4 weeks. Saliva samples were collected at Weeks 0, 2, 4, and 6, and Lactobacillus , Bifidobacterium and Streptococcus mutans populations and IgA concentration were measured. IgA concentrations, levels of TGF-beta and IL-10 in PBMCs cells were quantified by ELISA method. Results showed that salivary IgA levels were significantly increased on administration of both the viable (119.30 ± 12.63%, *** P < 0.001) and heat-killed (116.78 ± 12.28%, *** P < 0.001) probiotics for 4 weeks. Among three probiotic strains, AP-32 would effectively increase the levels of TGF-beta and IL-10 in PBMCs. The oral pathogen Streptococcus mutans was significantly reduced on viable probiotic tablet administration (49.60 ± 31.01%, *** P < 0.001). The in vitro antibacterial test confirmed that viable probiotics effectively limited the survival rate of oral pathogens. Thus, this clinical pilot study demonstrated that oral probiotic tablets both in viable form or heat-killed form could exert beneficial effects on oral immunity via IL-10, TGB-beta mediated IgA secretion. The effective dosage of viable probiotic content in the oral tablet was 10 9 CFUs/g and the heat-killed oral tablet was 1 × 10 10 cells/g.

Chemical Speciation and Interaction Mechanism of U in “Shewanella putrefaciens-Mineral-U” System - Jingqi Gao; Fengyu Huang; Wenjuan Yuan; Juan Cheng; Hexiang Huang; Jie Zhang; Facheng Yi; Hailing Zhang; Su Feng (Water, Air, & Soil Pollution, 2021)

Proteomics provides individualized options of precision medicine for patients with gastric cancer - Wenwen Huang; Dongdong Zhan; Yazhuo Li; Nairen Zheng; Xin Wei; Bin Bai; Kecheng Zhang; Mingwei Liu; Xuefei Zhao; Xiaotian Ni; Xia Xia; Jinwen Shi; et al. (Science China Life Sciences, 2021)

The major photoprotective role of anthocyanins in leaves of Arabidopsis thaliana under long-term high light treatment: antioxidant or light attenuator? - Xiao-Ting Zheng; Zheng-Chao Yu; Jun-Wei Tang; Min-Ling Cai; Yi-Lin Chen; Cheng-Wei Yang; Wah Soon Chow; Chang-Lian Peng (Photosynthesis Research, 2021)

The mTOR/NF-κB Pathway Mediates Neuroinflammation and Synaptic Plasticity in Diabetic Encephalopathy - Ting Xu; Jiao Liu; Xin-rui Li; Yinghua Yu; Xuan Luo; Xian Zheng; Yuan Cheng; Pei-quan Yu; Yi Liu (Molecular Neurobiology, 2021)

Mediation Effect of Health Beliefs in the Relationship Between Health Knowledge and Uptake of Mammography in a National Breast Cancer Screening Program in Taiwan - Hui-Min Hsieh; Wei-Chieh Chang; Cheng-Ting Shen; Yi Liu; Fang-Ming Chen; Ya-Ting Kang (Journal of Cancer Education, 2021)

Active components from Lagotis brachystachya maintain uric acid homeostasis by inhibiting renal TLR4-NLRP3 signaling in hyperuricemic mice - Ji-Xiao Zhu; Hai-Yan Yang; Wei-Qiong Hu; Jie Cheng; Yang Liu; Li-Tao Yi; Hong-Yu Cheng (Inflammopharmacology, 2021)

Extensions of the distributed lag non-linear model (DLNM) to account for cumulative mortality - Chao-Yu Guo; Xing-Yi Huang; Pei-Cheng Kuo; Yi-Hau Chen (Environmental Science and Pollution Research, 2021)
The effects of meteorological factors on health outcomes have gained popularity due to climate change, resulting in a general rise in temperature and abnormal climatic extremes. Instead of the conventional cross-sectional analysis that focuses on the association between a predictor and the single dependent variable, the distributed lag non-linear model (DLNM) has been widely adopted to examine the effect of multiple lag environmental factors health outcome. We propose several novel strategies to model mortality with the effects of distributed lag temperature measures and the delayed effect of mortality. Several attempts are derived by various statistical concepts, such as summation, autoregressive, principal component analysis, baseline adjustment, and modeling the offset in the DLNM. Five strategies are evaluated by simulation studies based on permutation techniques. The longitudinal climate and daily mortality data in Taipei, Taiwan, from 2012 to 2016 were implemented to generate the null distribution. According to simulation results, only one strategy, named MV DLNM , could yield valid type I errors, while the other four strategies demonstrated much more inflated type I errors. With a real-life application, the MV DLNM that incorporates both the current and lag mortalities revealed a more significant association than the conventional model that only fits the current mortality. The results suggest that, in public health or environmental research, not only the exposure may post a delayed effect but also the outcome of interest could provide the lag association signals. The joint modeling of the lag exposure and the delayed outcome enhances the power to discover such a complex association structure. The new approach MV DLNM models lag outcomes within 10 days and lag exposures up to 1 month and provide valid results.

Chitosan-based hydrogels to treat hydrofluoric acid burns and prevent infection - Shu-Wei Huang; Fang-Ching Yeh; You-Ren Ji; Ying-Fu Su; Ying-shih Su; Ming-Hsien Chiang; Shian-Chiuan Tzeng; Chien-Yao Fu; Aristine Cheng; Yung-Chih Wang; Yi-Tzu Lee (Drug Delivery and Translational Research, 2021)

Transdermal drug delivery systems for fighting common viral infectious diseases - Fang-Ying Wang; Yunching Chen; Yi-You Huang; Chao-Min Cheng (Drug Delivery and Translational Research, 2021)

Aestuariibaculum sediminum sp. nov., a marine bacterium isolated from a tidal flat in Zhoushan - Zhi-Cheng Wu; Xin-Yin Zhang; Cong Sun; Lin Xu; Ge-Yi Fu; Xue-Wei Xu (Archives of Microbiology, 2021)

Transcriptome analysis reveals hub genes in the hepatopancreas of Exopalaemon carinicauda in response to hypoxia and reoxygenation - Wenjun Shi; Pan Wang; Runhao Hu; Xihe Wan; Hui Shen; Hui Li; Libao Wang; Yi Qiao; Ge Jiang; Jie Cheng; Zeyu Yang (Aquaculture International, 2021)

Quantifying nitrate pollution sources of the drinking water source area using a Bayesian isotope mixing model in the northeastern suburbs of Beijing, China - Liangsuo Ren; Lirong Cheng; Shurong Zhang; Aizhong Ding; Yi Zhu; Chunlei Lu; Yu Li; Qing Yang; Jie Li (Isotopes in Environmental and Health Studies, 2021)

Short-term waterlogging-induced autophagy in root cells of wheat can inhibit programmed cell death - Li-Lang Zhou; Kai-Yue Gao; Li-Sha Cheng; Yue-Li Wang; Yi-Keng Cheng; Qiu-Tao Xu; Xiang-Yi Deng; Ji-Wei Li; Fang-Zhu Mei; Zhu-Qing Zhou (Protoplasma, 2021)

Transcriptome analysis of differentially expressed genes in chrysanthemum MET1 RNA interference lines - Dong-ru Kang; Yi Zhu; Shuai-lei Li; Peng-hui Ai; Muhammad Ayoub Khan; Hong-xu Ding; Ying Wang; Zi-cheng Wang (Physiology and Molecular Biology of Plants, 2021)

Genetic Analysis of ZNF Protein Family Members for Early-Onset Parkinson’s Disease in Chinese Population - Chun Yu Li; Ru Wei Ou; Yong Ping Chen; Xiao Jing Gu; Qian Qian Wei; Bei Cao; Ling Yu Zhang; Yan Bing Hou; Kun Cheng Liu; Xue Ping Chen; Wei Song; Bi Zhao; et al. (Molecular Neurobiology, 2021)

Fusarium solani G6, a novel vitexin-producing endophytic fungus: characterization, yield improvement and osteoblastic proliferation activity - Pei-jia Tang; Zhi-hui Zhang; Li-li Niu; Cheng-bo Gu; Wen-yi Zheng; Hai-chao Cui; Xiao-han Yuan (Biotechnology Letters, 2021)

Glaciibacter flavus sp. nov., isolated from a lichen sample - De-Feng An; Long-Qian Jiang; Kun Zhang; Gui-Ding Li; Xin-Yu Wang; Ming-Guo Jiang; Lei Lang; Li-Song Wang; Johannes F. Imhoff; Cheng-Lin Jiang; Yi Jiang (Archives of Microbiology, 2021)

Detection of Vestibular Schwannoma on Triple-parametric Magnetic Resonance Images Using Convolutional Neural Networks - Tzu-Hsuan Huang; Wei-Kai Lee; Chih-Chun Wu; Cheng-Chia Lee; Chia-Feng Lu; Huai-Che Yang; Chun-Yi Lin; Wen-Yuh Chung; Po-Shan Wang; Yen-Ling Chen; Hsiu-Mei Wu; Wan-You Guo; et al. (Journal of Medical and Biological Engineering, 2021)
Purpose The first step in typical treatment of vestibular schwannoma (VS) is to localize the tumor region, which is time-consuming and subjective because it relies on repeatedly reviewing different parametric magnetic resonance (MR) images. A reliable, automatic VS detection method can streamline the process. Methods A convolutional neural network architecture, namely YOLO-v2 with a residual network as a backbone, was used to detect VS tumors from MR images. To heighten performance, T1-weighted–contrast-enhanced, T2-weighted, and T1-weighted images were combined into triple-channel images for feature learning. The triple-channel images were cropped into three sizes to serve as input images of YOLO-v2. The VS detection effectiveness levels were evaluated for two backbone residual networks that downsampled the inputs by 16 and 32. Results The results demonstrated the VS detection capability of YOLO-v2 with a residual network as a backbone model. The average precision was 0.7953 for a model with 416 × 416-pixel input images and 16 instances of downsampling, when both the thresholds of confidence score and intersection-over-union were set to 0.5. In addition, under an appropriate threshold of confidence score, a high average precision, namely 0.8171, was attained by using a model with 448 × 448-pixel input images and 16 instances of downsampling. Conclusion We demonstrated successful VS tumor detection by using a YOLO-v2 with a residual network as a backbone model on resized triple-parametric MR images. The results indicated the influence of image size, downsampling strategy, and confidence score threshold on VS tumor detection.

Step Approximation for Water Wave Scattering by Multiple Thin Barriers over Undulated Bottoms - Chang-Thi Tran; Jen-Yi Chang; Chia-Cheng Tsai (Journal of Marine Science and Engineering, 2021)
This paper investigates the scattering of oblique water waves by multiple thin barriers over undulation bottoms using the eigenfunction matching method (EMM). In the solution procedures of the EMM, the bottom topographies are sliced into shelves separated by steps. On each step, surface-piercing or/and bottom-standing barriers can be presented or not. For each shelf, the solution is composed of eigenfunctions with unknown coefficients representing the wave amplitudes. Then applying the conservations of mass and momentum, a system of linear equations is resulted and can be solved by a sparse-matrix solver. If no barriers are presented on the steps, the proposed EMM formulation degenerates to the water wave scattering over undulating bottoms. The effects on the barrier lengths, barrier positions and oblique wave incidences by different undulated bottoms are studied. In addition, the EMM is also applied to solve the Bragg reflections of normal and oblique water waves by periodic barrier over sinusoidal bottoms. The accuracy of the solution is demonstrated by comparing it with the results in the literature.

Syntheses and anticancer activities of novel glucosylated (−)-epigallocatechin-3-gallate derivatives linked via triazole rings - Bo-Ya Shi; Ze-Hao Wang; Ning Zhang; Yin-Rong Xie; Xiu-Li Sun; Hao-Nan Yang; Yi-Long Wu; Cheng-Ting Zi; Xuan-Jun Wang; Jun Sheng (Medicinal Chemistry Research, 2021)

Enhancement of IUdR Radiosensitization in Cancer Therapy by Low-Energy Transmission X Ray Irradiation - Chien-Chih Ke; Jia-Je Li; Hsueh-Peng Wu; Wen-Wang Kuo; Yi-An Chen; Cheng-Hsiu Lu; Hsin-Ell Wang; Shih-Ming Hsu; Ya-Ju Hsieh; Ren-Shyan Liu (Journal of Medical and Biological Engineering, 2021)

Sodium azide induced high-oleic peanut (Arachis hypogaea L.) mutant of Virginia type - Rivalani Theorent Nkuna; Chuan Tang Wang; Xiu Zhen Wang; Yue Yi Tang; Zhi Wei Wang; Jian Cheng Zhang (Genetic Resources and Crop Evolution, 2021)

Response of water quality to land use in hydrologic response unit and riparian buffer along the Dan River, China - Xiaojun Liu; Yi Zhang; Zhanbin Li; Peng Li; Guoce Xu; Yuting Cheng; Tiegang Zhang (Environmental Science and Pollution Research, 2021)

Detection of Abandoned Coal Mine Goaf in China’s Ordos Basin Using the Transient Electromagnetic Method - Peng Wang; Qing Wang; Yi Wang; Cheng Wang (Mine Water and the Environment, 2021)

A mitochondria-localized pentatricopeptide repeat protein is required to restore hau cytoplasmic male sterility in Brassica napus - Huadong Wang; Qing Xiao; Chao Wei; Hui Chen; Xiaohan Chen; Cheng Dai; Jing Wen; Chaozhi Ma; Jinxing Tu; Tingdong Fu; Jinxiong Shen; Bin Yi (Theoretical and Applied Genetics, 2021)

Angiotensin converting enzyme inhibitors and angiotensin receptor blockers improved the outcome of patients with severe COVID-19 and hypertension - Xiao Meng; Ya Liu; Chenchen Wei; Kai Zhang; Yi Zhang; Ming Zhong; Cheng Zhang; Yun Zhang (Science China Life Sciences, 2021)

Paraventricular Nucleus P2X7 Receptors Aggravate Acute Myocardial Infarction Injury via ROS-Induced Vasopressin-V1b Activation in Rats - Wenjing Cheng; Yinggang Sun; Qin Wu; Kokwin Ooi; Yi Feng; Chunmei Xia; Danian Zhu (Neuroscience Bulletin, 2021)
The present study was designed to investigate the mechanisms by which P2X7 receptors (P2X7Rs) mediate the activation of vasopressinergic neurons thereby increasing sympathetic hyperactivity in the paraventricular nucleus (PVN) of the hypothalamus of rats with acute myocardial ischemia (AMI). The left anterior descending branch of the coronary artery was ligated to induce AMI in rats. The rats were pretreated with BBG (brilliant blue G, a P2X7R antagonist), nelivaptan (a vasopressin V1b receptor antagonist), or diphenyleneiodonium (DPI) [an nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor]. Hemodynamic parameters of the heart were monitored. Myocardial injury and cardiomyocyte apoptosis were assessed. In the PVN of AMI rats, P2X7R mediated microglial activation, while reactive oxygen species (ROS) and NADPH oxidase 2 (NOX2) were higher than in the sham group. Intraperitoneal injection of BBG effectively reduced ROS production and vasopressin expression in the PVN of AMI rats. Moreover, both BBG and DPI pretreatment effectively reduced sympathetic hyperactivity and ameliorated AMI injury, as represented by reduced inflammation and apoptosis of cardiomyocytes. Furthermore, microinjection of nelivaptan into the PVN improved cardiac function and reduced the norepinephrine (AE) levels in AMI rats. Collectively, the results suggest that, within the PVN of AMI rats, P2X7R upregulation mediates microglial activation and the overproduction of ROS, which in turn activates vasopressinergic neuron-V1b receptors and sympathetic hyperactivity, hence aggravating myocardial injury in the AMI setting.

Fibroblast Growth Factor 9 Stimulates Neuronal Length Through NF-kB Signaling in Striatal Cell Huntington’s Disease Models - Issa Olakunle Yusuf; Hsiu-Mei Chen; Pei-Hsun Cheng; Chih-Yi Chang; Shaw-Jenq Tsai; Jih-Ing Chuang; Chia-Ching Wu; Bu-Miin Huang; H. Sunny Sun; Chuan-Mu Chen; Shang-Hsun Yang (Molecular Neurobiology, 2021)

First report of cucurbit chlorotic yellows virus infecting melon, watermelon and wild melon in the Philippines - Hsin-Yi Chang; Li-Cheng Chen; Chung-Cheng Lin; Wen-Shi Tsai (Journal of Plant Pathology, 2021)

Bi-allelic BRWD1 variants cause male infertility with asthenoteratozoospermia and likely primary ciliary dyskinesia - Ting Guo; Chao-Feng Tu; Dan-Hui Yang; Shui-Zi Ding; Cheng Lei; Rong-Chun Wang; Lv Liu; Xi Kang; Xiao-Qing Shen; Yi-Feng Yang; Zhi-Ping Tan; Yue-Qiu Tan; et al. (Human Genetics, 2021)

Establishment and characterization of 38 novel patient-derived primary cancer cell lines using multi-region sampling revealing intra-tumor heterogeneity of gallbladder carcinoma - Feiling Feng; Qingbao Cheng; Bin Li; Chen Liu; Huizhen Wang; Bin Li; Xiaoya Xu; Yong Yu; Zishuo Chen; Xiaobing Wu; Hua Dong; Kaijian Chu; et al. (Human Cell, 2021)
Gallbladder carcinoma (GBC) is a lethal biliary tract malignant neoplasm. Patient-derived primary cancer cell lines (PDPCs) are appropriate models to explore biological characteristics and potential therapeutics; however, there is a lack of PDPCs in GBC. In this study, we aimed to establish and characterize the GBC PDPCs, and further investigated the intra-tumor heterogeneity (ITH). Multi-region sampling (3–9 regions) of the operable tumor tissue samples was used to establish PDPCs. Short tandem repeat genotyping for cell authentication and karyotyping was performed, followed by whole-exome sequencing and RNA sequencing to assess the ITH at the genetic and transcriptional levels, respectively. Thirty-eight PDPCs were successfully established from seven GBC patients and characterized. ITH was observed with a median of 38.3% mutations being heterogeneous (range, 26.6–59.4%) across all patients. Similar with other tumor types, TP53 mutations were always truncal. In addition, there were three genes, KMT2C , CDKN2A , and ARID1A , with truncal mutations in at least two patients. A median of 370 differentially expressed genes (DEGs) was identified per patient. Distinct expression patterns were observed between major histocompatibility complex (MHC) class I and II genes. We found the expression of MHC class II genes in the PDPC samples was closely regulated by CIITA , while that of MHC class I genes were not correlated with CIITA expression. The PDPCs established from GBC patients can serve as novel in vitro models to identify the ITH, which may pave a crucial molecular foundation for enhanced understanding of tumorigenesis and progression.

Application of Métier-Based Approaches for Spatial Planning and Management: A Case Study on a Mixed Trawl Fishery in Taiwan - Yi-Jou Lee; Nan-Jay Su; Hung-Tai Lee; William Wei-Yuan Hsu; Cheng-Hsin Liao (Journal of Marine Science and Engineering, 2021)
Mixed fisheries refer to fishing activities that catch more than one species simultaneously, and a species may be fished using different gear. A trawl fishery shares these features to exploit multiple species simultaneously, with diverse fishing gear and strategies. The situation becomes more complex when interactions among fleet dynamics, fishing activities, and fishery resources are involved and influence each other. Information regarding the operational patterns may be hidden in a set of long-term big data. This study aims to investigate the fishery structure and fleet dynamics of trawl fisheries in Taiwan for spatial planning and management, based on a long-term dataset from a management system that collects information by using voyage data recorders (VDR) and dockside observers. We applied a two-step data mining process with a clustering algorithm to classify the main groups of fishery resources and then identified 18 catch métiers based on catch composition. The target species, operation pattern, and fishing season were determined for each métier, and associated with the relevant fishery resources and the fishing gear used. Additionally, fishing effects on target species were estimated using information on fishing grounds and trajectories from VDR. The métier-based approach was successfully applied to define the six major fishery resources targeted by trawlers. We examined the key features of fishing activity associated with catch composition and spatial-temporal fishing metrics, which could be used to provide suggestions for the spatial planning and management of the mixed trawl fishery in the offshore waters of Taiwan.

Orbital-scale Asian summer monsoon variations: Paradox and exploration - Hai Cheng; Haiwei Zhang; Yanjun Cai; Zhengguo Shi; Liang Yi; Chenglong Deng; Qingzhen Hao; Youbing Peng; Ashish Sinha; Hanying Li; Jingyao Zhao; Ye Tian; et al. (Science China Earth Sciences, 2021)

Microbiological profiles and antimicrobial resistance patterns of pediatric bloodstream pathogens in China, 2016–2018 - Yue Qiu; Junwen Yang; Yiping Chen; Jinhong Yang; Qingxiong Zhu; Chunhui Zhu; Shuangjie Li; Jing Liu; Chaomin Wan; Yu Zhu; Minxia Chen; Yi Xu; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Regenerable, anti-biofouling covalent organic frameworks for monitoring and extraction of uranium from seawater - Yi-Di Wu; Wei-Rong Cui; Cheng-Rong Zhang; Ru-Ping Liang; Jian-Ding Qiu (Environmental Chemistry Letters, 2021)

Crenobacter intestini sp. nov., Isolated from the Intestinal Tract of Konosirus punctatus - Song-Biao Shi; Jia-Fa Wu; Li-Fang Yang; Ming-Guo Jiang; Cai-Mi Gao; Cheng-Lin Jiang; Yi Jiang (Current Microbiology, 2021)

Altered white matter structural networks in drug-naïve patients with obsessive-compulsive disorder - Cong Zhou; Liangliang Ping; Wei Chen; Mengxin He; Jian Xu; Zonglin Shen; Yi Lu; Binli Shang; Xiufeng Xu; Yuqi Cheng (Brain Imaging and Behavior, 2021)

Improving Oral Bioavailability of Luteolin Nanocrystals by Surface Modification of Sodium Dodecyl Sulfate - Jiali Liu; Yongbing Sun; Meng Cheng; Qiaoming Liu; Wan Liu; Chao Gao; Jianfang Feng; Yi Jin; Liangxing Tu (AAPS PharmSciTech, 2021)

COVID-19: advance in laboratory diagnostic strategy and technology - Kezhen Yi; Yuan Rong; Cheng Wang; Lanxiang Huang; Fubing Wang (Molecular and Cellular Biochemistry, 2021)

Correction to: Bibliometrics and visualization analysis regarding research on the development of microplastics - Mengjiao Zhou; Rou Wang; Shuiping Cheng; Yingfeng Xu; Sha Luo; Yi Zhang; Lingwei Kong (Environmental Science and Pollution Research, 2021)

A novel method for extraction of polypropylene microplastics in swine manure - Rui-Ting Wu; Ying-Feng Cai; Si-Cheng Xing; Yi-Wen Yang; Jian-Dui Mi; Xin-Di Liao (Environmental Science and Pollution Research, 2021)

Effects of degradation succession of alpine wetland on soil organic carbon and total nitrogen in the Yellow River source zone, west China - Chun-ying Lin; Xi-lai Li; Jing Zhang; Hua-fang Sun; Juan Zhang; Hui-bang Han; Qi-hua Wang; Cheng-biao Ma; Cheng-yi Li; Yu-xing Zhang; Xue-qian Ma (Journal of Mountain Science, 2021)

Small RNA Sequencing Analysis of Germinating Single-bud Seedcane Sett in Sugarcane - Kai-Chao Wu; Lin Xu; Zhi-Nian Deng; Tian Pang; Rong-Hua Zhang; Yi-Jie Li; Xiao-Yan Liu; Cheng-Feng Huang; Wen-Xian Qin; Jian-Feng Wei; Li-Ping Wei; Yang-Rui Li; et al. (Sugar Tech, 2021)

Detection of Shallow Buried Water-Filled Goafs Using the Fixed-Loop Transient Electromagnetic Method: A Case Study in Shaanxi, China - Peng Wang; Weihua Yao; Jianlei Guo; Chao Su; Qing Wang; Yi Wang; Buwen Zhang; Cheng Wang (Pure and Applied Geophysics, 2021)

Lactobacillus rhamnosus JYLR-005 Prevents Thiram-Induced Tibial Dyschondroplasia by Enhancing Bone-Related Growth Performance in Chickens - Fang Liu; Anan Kong; Pengfei Fu; Qin-qin Cao; Kun-sheng Tao; Di-yi Liu; Xue-bing Wang; Zong-xi Tong; Mujeeb Ur Rehman; Shu-cheng Huang (Probiotics and Antimicrobial Proteins, 2021)

Assisted selection of eating quality progeny of indica (O. sativa L. ssp. indica) and japonica (O. sativa L. ssp. japonica) hybrids using rice starch properties - Ting Mao; Zhan Zhang; Shan Jun Ni; Yi Zhou Zhao; Xin Li; Li Li Zhang; Yan Liu; Cheng Shun Zhong; He Huang; Shao Lin Wang; Xu Li (Genetic Resources and Crop Evolution, 2021)

Bibliometrics and visualization analysis regarding research on the development of microplastics - Mengjiao Zhou; Rou Wang; Shuiping Cheng; Yingfeng Xu; Sha Luo; Yi Zhang; Lingwei Kong (Environmental Science and Pollution Research, 2021)

Paracoccus lichenicola sp. nov., Isolated from Lichen - Lei Lang; De-Feng An; Long-Qian Jiang; Gui-Ding Li; Li-Song Wang; Xin-Yu Wang; Qin-Yuan Li; Cheng-Lin Jiang; Yi Jiang (Current Microbiology, 2021)

Aberrant methylation of the 16q23.1 tumor suppressor gene ADAMTS18 promotes tumorigenesis and progression of clear cell renal cell carcinoma - Ben Xu; Yi-ji Peng; Bing-lei Ma; Si-da Cheng (Genes & Genomics, 2021)

Status, spatial distribution, and health risk assessment of potentially harmful element from road dust in steel industry city, China - Jinjin Wang; Yi Huang; Xin Cheng (Arabian Journal of Geosciences, 2021)

Rapid assessment of landslide risk level based on deep learning - Fei Tan; Jin Yu; Yu-Yong Jiao; Dawei Lin; Jiahe Lv; Yi Cheng (Arabian Journal of Geosciences, 2021)

MiR396 regulatory network and its expression during grain development in wheat - Yi Yu; Fangyao Sun; Ning Chen; Genlou Sun; Cheng-Yu Wang; De-Xiang Wu (Protoplasma, 2021)

A CCR4-associated factor 1, OsCAF1B, confers tolerance of low-temperature stress to rice seedlings - Jhen-Cheng Fang; Yin-Chuan Tsai; Wei-Lun Chou; Hsin-Yi Liu; Chun-Chen Chang; Shaw-Jye Wu; Chung-An Lu (Plant Molecular Biology, 2021)

Effects of Different Component Contents of Colistin Methanesulfonate on the Pharmacokinetics of Prodrug and Formed Colistin in Human - Ya-Xin Fan; Yuan-Cheng Chen; Yi Li; Ji-Cheng Yu; Xing-Chen Bian; Xin Li; Wan-Zhen Li; Bei-Ning Guo; Hai-Lan Wu; Xiao-Fen Liu; Yu Wang; Xiao-Yong Xu; et al. (Pharmaceutical Research, 2021)

Assessment of toxic elements in road dust from Hutou Village, China: implications for the highest incidence of lung cancer - Zailin Chen; Yi Huang; Xin Cheng; Shijun Ni; Jinjin Wang; Bangzheng Ren; Qiulian Yu (Environmental Science and Pollution Research, 2021)

Improving the observation and prediction capabilities for Arctic marine environment: from the perspective of Arctic Shipping - Hui Wang; Qizhen Sun; Lin Zhang; Xi Liang; Qinghua Yang; Na Liu; Chunhua Li; Qingsheng Liu; Bingrui Li; Qian Feng; Xiao Cheng; Yi Yu (Acta Oceanologica Sinica, 2021)

Nitrogen placement at sowing affects root growth, grain yield formation, N use efficiency in maize - Yi Cheng; Hui-Qin Wang; Peng Liu; Shu-Ting Dong; Ji-Wang Zhang; Bin Zhao; Bai-Zhao Ren (Plant and Soil, 2020)

Concurrent increases in post-pacing action potential duration and contractility predict occurrence of ventricular arrhythmia - Chih-Min Liu; Feng-Zhi Lin; Yao-Chang Chen; Yung-Kuo Lin; Yen-Yu Lu; Cheng-I Wu; Satoshi Higa; Shih-Ann Chen; Yi-Jen Chen (Pflügers Archiv - European Journal of Physiology, 2020)

Evaluation of crustal inhomogeneity parameters in the southern Longmenshan fault zone and adjacent regions - Xiao-Ping Fan; Yi-Cheng He; Cong-Jie Yang; Jun-Fei Wang (Journal of Seismology, 2020)
Broadband teleseismic waveform data from 13 earthquakes recorded by 70 digital seismic stations were selected to evaluate the inhomogeneity parameters of the crustal medium in the southern Longmenshan fault zone and its adjacent regions using the teleseismic fluctuation wavefield method. Results show that a strong inhomogeneity exists beneath the study region, which can be divided into three blocks according to its structure and tectonic deformation features. These are known as the Sichuan-Qinghai Block, the Sichuan-Yunnan Block, and the Mid-Sichuan Block. The velocity fluctuation ratios of the three blocks are approximately 5.1%, 3.6%, and 5.1% in the upper crust and 5.1%, 3.8%, and 4.9% in the lower crust. The inhomogeneity correlation lengths of the three blocks are about 10.1 km, 14.0 km, and 10.7 km in the upper crust and 11.8 km, 17.0 km, and 11.8 km in the lower crust. The differences in the crustal medium inhomogeneity beneath the Sichuan-Yunnan Block, the Sichuan-Qinghai Block, and the Mid-Sichuan Block may be related to intensive tectonic movement and material flow in the crust and upper mantle.

A Clipless Pedal-Sensor System for Three Dimensional Kinetic Analysis During Cycling - Kai-Han Liang; Hong-Wen Wu; Li-Cheng Hsieh; Yi-Wen Chang (Journal of Medical and Biological Engineering, 2020)

Melatonin ameliorates spatial memory and motor deficits via preserving the integrity of cortical and hippocampal dendritic spine morphology in mice with neurotrauma - Xiao-Jing Lin; Ruoxu Liu; Chenyi Li; Xueqing Yi; Bo Fu; M. J. Walker; Xiao-Ming Xu; Gang Sun; Cheng-Hsien Lin (Inflammopharmacology, 2020)

Effect on intestinal microbiota, bioaccumulation, and oxidative stress of Carassius auratus gibelio under waterborne cadmium exposure - Nan Wang; Zhengyao Guo; Yilin Zhang; Peijun Zhang; Jia Liu; Yi Cheng; Lei Zhang; Yuehong Li (Fish Physiology and Biochemistry, 2020)

Identifying ephemeral gullies from high-resolution images and DEMs using flow-directional detection - Wen Dai; Guang-hui Hu; Xin Yang; Xian-wu Yang; Yi-han Cheng; Li-yang Xiong; Josef Strobl; Guo-an Tang (Journal of Mountain Science, 2020)

Sulfide ore prospecting in carbon-containing stratum using comprehensive time-domain induced polarization and controlled-source audio-frequency magnetotellurics - Ren-Bin Sun; Li-Xia Chu; Gui-Bin Zhang; Qiu-Ming Cheng; Yun-Chuan Xiang; Bin Hu; Chang-Rong Zhang; Jian-Fu Li; Yi-Jun Zhao (Applied Geophysics, 2020)

Structural insights into Arabidopsis ethylene response factor 96 with an extended N-terminal binding to GCC box - Chun-Yen Chen; Pei-Hsuan Lin; Kun-Hung Chen; Yi-Sheng Cheng (Plant Molecular Biology, 2020)
The phytohormone ethylene is widely involved in many developmental processes and is a crucial regulator of defense responses against biotic and abiotic stresses in plants. Ethylene-responsive element binding protein, a member of the APETALA2/ethylene response factor (AP2/ERF) superfamily, is a transcription factor that regulates stress-responsive genes by recognizing a specific cis -acting element of target DNA. A previous study showed only the NMR structure of the AP2/ERF domain of AtERF100 in complex with a GCC box DNA motif. In this report, we determined the crystal structure of AtERF96 in complex with a GCC box at atomic resolution. We analyzed the binding residues of the conserved AP2/ERF domain in the DNA recognition sequence. In addition to the AP2/ERF domain, an N-terminal α-helix of AtERF96 participates in DNA interaction in the flanking region. We also demonstrated the structure of AtERF96 EDLL motif, a unique conserved motif in the group IX of AP2/ERF family, might involve in the transactivation of defense-related genes. Our study establishes the structural basis of the AtERF96 transcription factor in complex with the GCC box, as well as the DNA binding mechanisms of the N-terminal α-helix and AP2/ERF domain.

One-pot synthesis of substituted pyrrole–imidazole derivatives with anticancer activity - Ming Zhang; Yong Ding; Hong-Xia Qin; Zhi-Gang Xu; Hai-Tao Lan; Dong-Lin Yang; Cheng Yi (Molecular Diversity, 2020)

Functional Analysis of a Fibronectin Binding Protein of Streptococcus parasanguinis FW213 - Yi-Ywan M. Chen; Pei-Shan Lu; Pei-Hua Tsai; Cheng-Hsun Chiu (Current Microbiology, 2020)

Correction to: Complete genome sequences of two novel dicistroviruses detected in yellow crazy ants (Anoplolepis gracilipes) - Chih-Chi Lee; Chun-Yi Lin; Hung-Wei Hsu; Chin-Cheng Scotty Yang (Archives of Virology, 2020)

Complete genome sequences of two novel dicistroviruses detected in yellow crazy ants (Anoplolepis gracilipes) - Chih-Chi Lee; Chun-Yi Lin; Hung-Wei Hsu; Chin-Cheng Scotty Yang (Archives of Virology, 2020)

Antibacterial effect of Blumea balsamifera DC. essential oil against Haemophilus parasuis - Changliang He; Peiyi Yang; Lu Wang; Xiaolin Jiang; Wei Zhang; Xiaoxia Liang; Lizi Yin; Zhongqiong Yin; Yi Geng; Zhijun Zhong; Xu Song; Yuanfeng Zou; et al. (Archives of Microbiology, 2020)

Dynamics of Microbial Community Structure and Ecological Functions in Estuarine Intertidal Sediments - Jun Yi; Linus Shing Him Lo; Jinping Cheng (Frontiers in Marine Science, 2020)

Lysosomal Hydrolase Cathepsin D Non-proteolytically Modulates Dendritic Morphology in Drosophila - Ting Zhang; Daxiao Cheng; Cunjin Wu; Xingyue Wang; Qiang Ke; Huifang Lou; Liya Zhu; Xiao-Dong Wang; Shumin Duan; Yi-Jun Liu (Neuroscience Bulletin, 2020)
The main lysosomal protease cathepsin D (cathD) is essential for maintaining tissue homeostasis via its degradative function, and its loss leads to ceroid accumulation in the mammalian nervous system, which results in progressive neurodegeneration. Increasing evidence implies non-proteolytic roles of cathD in regulating various biological processes such as apoptosis, cell proliferation, and migration. Along these lines, we here showed that cathD is required for modulating dendritic architecture in the nervous system independent of its traditional degradative function. Upon cathD depletion, class I and class III arborization (da) neurons in Drosophila larvae exhibited aberrant dendritic morphology, including over-branching, aberrant turning, and elongation defects. Re-introduction of wild-type cathD or its proteolytically-inactive mutant dramatically abolished these morphological defects. Moreover, cathD knockdown also led to dendritic defects in the adult mushroom bodies, suggesting that cathD-mediated processes are required in both the peripheral and central nervous systems. Taken together, our results demonstrate a critical role of cathD in shaping dendritic architecture independent of its proteolytic function.

Liquiritin inhibits proliferation and induces apoptosis in HepG2 hepatocellular carcinoma cells via the ROS-mediated MAPK/AKT/NF-κB signaling pathway - Jia-Ru Wang; Tian-Zhu Li; Cheng Wang; Shu-Mei Li; Ying-Hua Luo; Xian-Ji Piao; Yu-Chao Feng; Yi Zhang; Wan-Ting Xu; Yu Zhang; Tong Zhang; Shi-Nong Wang; et al. (Naunyn-Schmiedeberg's Archives of Pharmacology, 2020)

Characterization of Model Uncertainty for the Vertical Pullout Capacity of Helical Anchors in Cohesive Soils - Po Cheng; Jiang Tao Yi; Fei Liu; Jun Jie Dong (Journal of Marine Science and Engineering, 2020)
This paper conducts coupled Eulerian–Lagrangian (CEL) analysis to characterize the model uncertainty of using the cylindrical shear method (CSM) to predict the pullout capacity of helical anchors in cohesive soils. The model factor M is adopted to represent the model uncertainty, which is equal to the value of measured capacity divided by estimated solution. The model factor Mcel can be considered to be a random variable with a lognormal distribution, and its mean value and coefficient of variation (COV) are 1.02 and 0.1, respectively. Correction factor η is introduced when comparing CSM and CEL, which is found to be influenced by input parameters. The dependence on input parameters is removed by performing regression analysis and the regression equation f is obtained. Substituting the regression equation f into the original CSM constitutes the modified CSM (MCSM), and the model factor of MCSM can be modeled as a random variable with a lognormal distribution, and its mean value and COV are 1.02 and 0.13, respectively. Finally, 13 filed tests are collected to compare the prediction accuracy, the results show that the prediction error range of MCSM is mostly within 15%. The present findings might be helpful for engineers and designers to estimate the pullout capacity of helical anchors in cohesive soils more confidently.

2(5H)-Furanone Disrupts Bacterial Biofilm Formation and Indirectly Reduces the Settlement of Plantigrades of the Mussel Mytilus coruscus - Yi-Feng Li; Xin Zhu; Zhi-Yang Cheng; Xiao Liang; You-Ting Zhu; Dan-Dan Feng; Sergey Dobretsov; Jin-Long Yang (Frontiers in Marine Science, 2020)

Archaeobotanical evidence reveals the human–environment interactions during the 9th–13th centuries at Turpan, Xinjiang on the ancient Silk Road - Yi-Feng Yao; Xia Wang; Wu Guo; Hong-En Jiang; Min Li; David K. Ferguson; Yu-Fei Wang; Cheng-Sen Li (Vegetation History and Archaeobotany, 2020)

Powder Mass of Coal After Impact Crushing: A New Fractal-Theory-Based Index to Evaluate Rock Firmness - Chenghao Wang; Yuanping Cheng; Minghao Yi; Yang Lei; Xinxin He (Rock Mechanics and Rock Engineering, 2020)

Upregulation of miR-133a-3p in the Sciatic Nerve Contributes to Neuropathic Pain Development - Lin-Li Chang; Hung-Chen Wang; Kuang-Yi Tseng; Miao-Pei Su; Jaw-Yuan Wang; Yi-Ta Chuang; Yi-Hsuan Wang; Kuang-I Cheng (Molecular Neurobiology, 2020)

Protein phosphorylation profiling of peripheral nerve regeneration after autologous nerve grafting - Zhangchun Cheng; Yinying Shen; Tianmei Qian; Sheng Yi; Jianghong He (Molecular and Cellular Biochemistry, 2020)

New gravimetric-only and hybrid geoid models of Taiwan for height modernisation, cross-island datum connection and airborne LiDAR mapping - Cheinway Hwang; Hung-Jui Hsu; W. E. Featherstone; Ching-Chung Cheng; Ming Yang; Wenhsuan Huang; Chong-You Wang; Jiu-Fu Huang; Kwo-Hwa Chen; Chi-Hsun Huang; Hechin Chen; Wen-Yi Su (Journal of Geodesy, 2020)

Key Role of Pro-inflammatory Cytokines in the Toxic Effect of Fluoride on Hepa1-6 Cells - Yan Zhang; Bian-hua Zhou; Pan-pan Tan; Yu Chen; Cheng-yi Miao; Hong-wei Wang (Biological Trace Element Research, 2020)

Potential probiotic of Lactobacillus strains isolated from the intestinal tracts of pigs and feces of dogs with antibacterial activity against multidrug-resistant pathogenic bacteria - Chuen-Fu Lin; Meng-Yi Lin; Chao-Nan Lin; Ming-Tang Chiou; Jia-Wen Chen; Kai-Chieh Yang; Ming-Cheng Wu (Archives of Microbiology, 2020)

Comparing Subsurface Seasonal Deoxygenation and Acidification in the Yellow Sea and Northern East China Sea Along the North-to-South Latitude Gradient - Tian-qi Xiong; Qin-sheng Wei; Wei-dong Zhai; Cheng-long Li; Song-yin Wang; Yi-xing Zhang; Shuo-jiang Liu; Si-qing Yu (Frontiers in Marine Science, 2020)

A new phenanthropyran and a new biphenanthrene from the rhizomes of Dioscorea septemloba and their antioxidant activities - Tao He; Yi Liu; Rui-Feng Xiong; Xiao-Yu Li; Shou-Feng Wang; Chun-Ru Cheng (Natural Product Research, 2020)

Clinical and Genetic Characterization of Autosomal Recessive Spinocerebellar Ataxia Type 16 (SCAR16) in Taiwan - Hsu-Huai Chiu; Cheng-Tsung Hsaio; Yu-Shuen Tsai; Yi-Chu Liao; Yi-Chung Lee; Bing-Wen Soong (The Cerebellum, 2020)

The effect of follower load on the range of motion, facet joint force, and intradiscal pressure of the cervical spine: a finite element study - Xin-Yi Cai; Chen-Xi YuChi; Cheng-Fei Du; Zhong-Jun Mo (Medical & Biological Engineering & Computing, 2020)

The Health Promoting Mindfulness or Qigong Educational Programs for Beneficial Lifestyle Changes of Cancer Survivors - Tse-Chou Cheng; Yi-Hua Lee; Chun-Lin Mar; Wen-Tsung Huang; Yuan-Ping Chang (Journal of Cancer Education, 2020)

Nakamurella albus sp. nov.: A Novel Actinobacterium Isolated from a Lichen Sample - Long-Qian Jiang; De-Feng An; Kun Zhang; Gui-Ding Li; Xin-Yu Wang; Lei Lang; Ming-Guo Jiang; Li-Song Wang; Cheng-Lin Jiang; Yi Jiang (Current Microbiology, 2020)

Reconnaissance and learning after the February 6, 2018, earthquake in Hualien, Taiwan - Jui-Liang Lin; Chun-Hsiang Kuo; Yu-Wen Chang; Shu-Hsien Chao; Yi-An Li; Wen-Cheng Shen; Chung-Han Yu; Cho-Yen Yang; Fan-Ru Lin; Hsiao-Hui Hung; Chun-Chung Chen; Chin-Kuo Su; et al. (Bulletin of Earthquake Engineering, 2020)

Annual Characteristics, Source Analysis of PM1-Bound Potentially Harmful Elements in the Eastern District of Chengdu, China - Jinjin Wang; Yi Huang; Ting Li; Huibin Shi; Min He; Xin Cheng; Shijun Ni; Chengjiang Zhang (Archives of Environmental Contamination and Toxicology, 2020)

Composition, Distribution, and Assembly Patterns of Eukaryotic Communities Under Vertical Geochemical Gradients in a Polluted Urban River - Wei Cai; Yi Li; Wenlong Zhang; Lihua Niu; Longfei Wang; Haomiao Cheng (Water, Air, & Soil Pollution, 2020)

Relationship Between Seismic Moment and Source Duration for Seismogenic Earthquakes in Taiwan: Implications for the Product of Static Stress Drop and the Cube of Rupture Velocity - Ruey-Der Hwang; Cheng-Ying Ho; Tzu-Wei Lin; Wen-Yen Chang; Yi-Ling Huang; Cai-Yi Lin; Chiung-Yao Lin (Pure and Applied Geophysics, 2020)

Metabolomics analysis of nitrogen-containing metabolites between two Dendrobium plants - Cheng Song; Chunyan Jiao; Qing Jin; Cunwu Chen; Yongping Cai; Yi Lin (Physiology and Molecular Biology of Plants, 2020)

Risk perception and response toward climate change for higher education students in Taiwan - Tai-Kuei Yu; Joseph P. Lavallee; Bruno Di Giusto; I-Cheng Chang; Tai-Yi Yu (Environmental Science and Pollution Research, 2020)

Dredging method effects on sediment resuspension and nutrient release across the sediment-water interface in Lake Taihu, China - Chao Chen; Ming Kong; Yi-Yao Wang; Qiu-Shi Shen; Ji-Cheng Zhong; Cheng-Xin Fan (Environmental Science and Pollution Research, 2020)

Toxicity assessment of electrochemical advanced oxidation process-treated groundwater from a gas station with petrochemical contamination - How-Ran Chao; Danielle E. Que; Alisha C. Aquino; Yan-You Gou; Lemmuel L. Tayo; Yi-Hsien Lin; Ming-Hsien Tsai; Fu-Lin Hsu; I-Cheng Lu; Sheng-Lun Lin; Natwat Srikhao; Cherng-Gueih Shy; et al. (Environmental Monitoring and Assessment, 2020)

Source apportionment and health risk assessment of air pollution particles in eastern district of Chengdu - Yi Huang; Li Wang; Shipeng Zhang; Meng Zhang; Jinjin Wang; Xin Cheng; Ting Li; Min He; Shijun Ni (Environmental Geochemistry and Health, 2020)

Beach ridges of Dali Lake in Inner Mongolia reveal precipitation variation during the Holocene - Mengyao Jiang; Zhiyong Han; Xusheng Li; Yong Wang; Thomas Stevens; Jun Cheng; Cunjuan Lv; Yuwen Zhou; Qianqian Yang; Zhiwei Xu; Shuangwen Yi; Huayu Lu (Journal of Quaternary Science, 2020)
Variability in East Asian summer monsoon precipitation during the Holocene remains of debate. In this study, we use a closed lake with well‐dated lake beach ridges located on the margin of the East Asian summer monsoon, a region highly sensitive to monsoon precipitation changes, to obtain a temporal sequence of water volume in North China. The elevation of each beach ridge calibrated to the modern lake level was surveyed. Optically stimulated luminescence dating of undisturbed sediments of beach ridges was performed. The lake area and water volume corresponding to each beach ridge were calculated using a digital elevation model. This study reveals relatively reduced monsoon precipitation from ~12 to 7 ka interrupted by strengthening of the monsoon circulation to a maximum from ~7 to ~5 ka and followed by greatly reduced monsoon intensity until the present day. These results demonstrate that changes in the East Asian summer monsoon precipitation may not be directly driven by global temperature or atmospheric CO 2 content. Rather, we suggest that variation in the the monsoon margin precipitation is probably mainly driven by ice volume and subordinately by the summer solar insolation difference between mid‐latitude land and low‐latitude ocean.

Population Genetic Analysis for Stock Enhancement of Silver Sea Bream (Rhabdosargus sarba) in Taiwan - Te-Hua Hsu; Chang-Wen Huang; Hung-Tai Lee; Yi-Hsuan Kuo; Kwang-Ming Liu; Cheng-Hui Lin; Hong-Yi Gong (Fishes, 2020)
Stock enhancement is a method for replenishing depleted wild finfish populations by supplementing them with hatchery-raised fish. In Taiwan, silver sea bream (Rhabdosargus sarba) is a predominant commercial species involved in stock enhancement projects. Although management agencies conduct stock enhancement projects, there are a lot of private releases without records. Stock enhancement is performed by the private aquaculture sector without accurate genetic records, potentially leading to unintended consequences for wild populations. We analyzed the genetics of 459 wild and 701 hatchery-reared specimens from nine batches produced by various hatcheries. Wild and hatchery-reared samples could be considered two separate clades by using a set of stable and informative microsatellite markers including type I (from gene introns and 3′UTR) and type II markers (randomly picked up from genome). Type I microsatellite markers could more sensitively reflect the loss of genetic diversity more than type II markers in the domestication process. All specimens were considered native by using mtDNA COI and microsatellites. The genetic composition of the wild population is relatively simple, and the estimated low contribution rate of the hatchery stock (1.3–10.9%; 6–50/459) indicated a weak but significant genetic effect of stock enhancement. Therefore, establishing standards for the stock enhancement of silver sea bream for more effective supplementation of wild populations is imperative.

Genetic analysis and fine mapping of the gall midge resistance gene Gm5 in rice (Oryza sativa L.) - Hailian Zhou; Xinyi Wang; Yi Mo; Yang Li; Liuhui Yan; Zhihua Li; Wan Shu; Ling Cheng; Fengkuan Huang; Yongfu Qiu (Theoretical and Applied Genetics, 2020)

Outflow sediment concentration forecasting by integrating machine learning approaches and time series analysis in reservoir desilting operation - Ming-Jui Chang; Gwo-Fong Lin; Fong-Zuo Lee; Yi-Cheng Wang; Peng-An Chen; Ming-Chang Wu; Jihn-Sung Lai (Stochastic Environmental Research and Risk Assessment, 2020)

Hispidulin Inhibits Neuroinflammation in Lipopolysaccharide-Activated BV2 Microglia and Attenuates the Activation of Akt, NF-κB, and STAT3 Pathway - Chung-I Yu; Cheng-I Cheng; Ya-Fei Kang; Po-Chih Chang; In-Pin Lin; Yu-His Kuo; An-Jie Jhou; Mei-Ying Lin; Chung-Yi Chen; Chien-Hsing Lee (Neurotoxicity Research, 2020)

Reversal of Social Recognition Deficit in Adult Mice with MECP2 Duplication via Normalization of MeCP2 in the Medial Prefrontal Cortex - Bin Yu; Bo Yuan; Jian-Kun Dai; Tian-lin Cheng; Sheng-Nan Xia; Ling-Jie He; Yi-Ting Yuan; Yue-Fang Zhang; Hua-Tai Xu; Fu-Qiang Xu; Zhi-Feng Liang; Zi-Long Qiu (Neuroscience Bulletin, 2020)

P-wave velocity structures of the crust across the Southern Taiwan Strait imaged by using air-gun data recorded from ocean-bottom seismometers - Tan K. Wang; Jia Ming Deng; Jing Wang; Yu Hsuan Cheng; Zhi Zhao Xie; Yi Feng Zhang (Marine Geophysical Research, 2020)

Cognitive Load of Exercise Influences Cognition and Neuroplasticity of Healthy Elderly: An Exploratory Investigation - Yi-Ping Chao; Changwei W. Wu; Li-Jung Lin; Cheng-Hung Lai; Hong-Yi Wu; Ai-Ling Hsu; Chiao-Nan Chen (Journal of Medical and Biological Engineering, 2020)
This study explored the effects of exercise with either high cognitive load or low cognitive load on cognitive performance and neuroplasticity in healthy elderly. Twenty-eight sedentary community-dwelling seniors participated in this study. Participants were assigned to one of three groups: the control group (C), low-cognitive load exercise group (LE), or high-cognitive load exercise group (HE). Individuals in both exercise groups engaged in moderate-intensity aerobic exercise for 4 months. Resting-state functional MRI and diffusion MRI were used to investigate the effects of intervention on functional and structural connectivity, respectively. Analysis of covariance with baseline, age and the education year as covariates was used to determine the effects of intervention. We found 4 months of exercise with high-cognitive load, but not exercise with low-cognitive load, improved the overall cognitive function of healthy elderly. Additionally, the HE group showed increased resting-state functional connectivity of superior frontal gyrus and anterior cingulate cortex and decreased functional connectivity of middle occipital gyrus and postcentral gyrus. The age-related alterations in local efficiency and betweenness were protected by exercise. Our findings might suggest that exercise with greater cognitive load likely results in greater training effects on cognition and brain connectivity than exercise requiring lower cognitive loads for healthy elderly.

Statistical Analysis on Heart Rate Variability for Graded Cardiopulmonary Groups with Different Exercise Intensities - Ching-Kun Chen; Shyan-Lung Lin; Cheng-Yi Huang; Tasi-Chu Wang; Ting-Yen Yao; Chieh-Liang Wu (Journal of Medical and Biological Engineering, 2020)

Short-term associations between ambient fine particulate matter pollution and hospital visits for chronic obstructive pulmonary disease in Yinzhou District, China - Cheng-yi Lin; Die Li; Jie-ming Lu; Zhe-bin Yu; Yao Zhu; Peng Shen; Meng-ling Tang; Ming-juan Jin; Hong-bo Lin; Li-ming Shui; Kun Chen; Jian-bing Wang (Environmental Science and Pollution Research, 2020)

Effects of Hyperbaric Oxygen Therapy on Acute Myocardial Infarction Following Carbon Monoxide Poisoning - Chien-Cheng Huang; Chung-Han Ho; Yi-Chen Chen; Chien-Chin Hsu; Hung-Jung Lin; Jhi-Joung Wang; Shih-Bin Su; How-Ran Guo (Cardiovascular Toxicology, 2020)

Recent advances in targeting cancer stem cells using oncolytic viruses - You-Ni Zhang; Shi-Bing Wang; Shu-Shu Song; Pei-Yang Hu; Yu-Cheng Zhou; Yi-Ping Mou; Xiao-Zhou Mou (Biotechnology Letters, 2020)

Genetic sequence changes related to the attenuation of avian infectious bronchitis virus strain TW2575/98 - Cheng-Ta Tsai; Hung-Yi Wu; Ching-Ho Wang (Virus Genes, 2020)

A special symptom of olfactory dysfunction in coronavirus disease 2019: report of three cases - Chen Chen; Moxian Chen; Cong Cheng; Yun Chi; Zhiliang Hu; Yuan Liu; Shan Huang; Yanling Lv; Chongfeng Liang; Damin Jiao; Yongxiang Yi; Xia Zhang; et al. (Journal of NeuroVirology, 2020)

Reverse time migration imaging of tunnels via the finite element method using an unstructured mesh - Jing Wang; Jiang-Ping Liu; Fei Cheng; Huai-Jie Yang; Yi-Fan Huang (Applied Geophysics, 2020)

Anti-phytopathogenic Bacterial Metabolites From the Seaweed-Derived Fungus Aspergillus sp. D40 - Rui-Huan Huang; Wei Lin; Peng Zhang; Jian-Yang Liu; Dan Wang; Yi-Qiang Li; Xiao-Qiang Wang; Cheng-Sheng Zhang; Wei Li; Dong-Lin Zhao (Frontiers in Marine Science, 2020)

CmCYC2-like transcription factors may interact with each other or bind to the promoter to regulate floral symmetry development in Chrysanthemum morifolium - Cunquan Yuan; Di Huang; Yi Yang; Ming Sun; Tangren Cheng; Jia Wang; Huitang Pan; Qixiang Zhang (Plant Molecular Biology, 2020)

Complete mitogenomic and phylogenetic characteristics of the speckled wood-pigeon (Columba hodgsonii) - Hong-Yi Liu; Cheng-He Sun; Ying Zhu; Qing-Zheng Zhang (Molecular Biology Reports, 2020)

Overexpression of MYBL2 promotes proliferation and migration of non-small-cell lung cancer via upregulating NCAPH - Yu-Chao Xiong; Jiao Wang; Yong Cheng; Xin-Yi Zhang; Xiao-Qun Ye (Molecular and Cellular Biochemistry, 2020)

Correction to: Galangin inhibits hypertrophic scar formation via ALK5/Smad2/3 signaling pathway - Yifan Zhang; Shengzhou Shan; Jing Wang; Xinyu Cheng; Bo Yi; Jia Zhou; Qingfeng Li (Molecular and Cellular Biochemistry, 2020)

Biocontrol potential of Bacillus subtilis IBFCBF-4 against Fusarium wilt of watermelon - Jiuxiang Zhu; Taimeng Tan; Airong Shen; Xiebin Yang; Yongting Yu; Chunsheng Gao; Zhimin Li; Yi Cheng; Jia Chen; Litao Guo; Xiangping Sun; Zhun Yan; et al. (Journal of Plant Pathology, 2020)

Genome-wide identification and characterization of long non-coding RNAs during differentiation of visceral preadipocytes in rabbit - Kun Du; Guo-Ze Wang; An-yong Ren; Ming-cheng Cai; Gang Luo; Xian-bo Jia; Shen-qiang Hu; Jie Wang; Shi-Yi Chen; Song-Jia Lai (Functional & Integrative Genomics, 2020)

Multiple genetic factors affecting the pharmacokinetic and pharmacodynamic processes of tacrolimus in Chinese myasthenia gravis patients - Huan-Yu Meng; Xi Li; Wan-Lin Jin; Cheng-Kai Yan; Xiao-Hua Dong; Qiu Xu; Yu-Yao Peng; Zhi-Bin Li; Yi Li; Zhao-Hui Luo; Li-Qun Xu; Huan Yang (European Journal of Clinical Pharmacology, 2020)

Shewanella oneidensis MR-1 impregnated Ca-alginate capsule for efficient Cr(VI) reduction and Cr(III) adsorption - Cheng Yu; Yi Zhang; Yu Fang; Yujie Tan; Ke Dai; Shilin Liu; Qiaoyun Huang (Environmental Science and Pollution Research, 2020)

Sub-type source profiles of fine particles for fugitive dust and accumulative health risks of heavy metals: a case study in a fast-developing city of China - Fangqi Wu; Shaofei Kong; Qin Yan; Wei Wang; Haibiao Liu; Jian Wu; Huang Zheng; Shurui Zheng; Yi Cheng; Zhenzhen Niu; Dantong Liu; Shihua Qi (Environmental Science and Pollution Research, 2020)