Experimental study on the pore and solid structures of municipal solid waste under compression based on computed tomography (CT) scans - Han Ke; Ying Liu; Meng Meng; Jie Hu; Shi Yu Zhao; Rui Qin; Xiao Wen Wu (Environmental Science and Pollution Research, 2022)

Genome-based reclassification of the genus Meiothermus along with the proposal of a new genus Allomeiothermus gen. nov - Jian-Yu Jiao; Zheng-Han Lian; Ze-Tao Liu; Lan Liu; Meng-Meng Li; Ai-Ping Lv; Wen-Dong Xian; Ting Zhou; Zhitang Lyu; Nimaichand Salam; Wen-Jun Li (Antonie van Leeuwenhoek, 2022)

Albumin-Embellished Arsenic Trioxide-Loaded Polymeric Nanoparticles Enhance Tumor Accumulation and Anticancer Efficacy via Transcytosis for Hepatocellular Carcinoma Therapy - Yu Huang; Zhishi Xu; Yinghui Wei; Shunping Han; Xinjun Cai; Danfei Chen (AAPS PharmSciTech, 2022)

Hypothermal Effects on Energy Supply for Ionocytes in Gills of Freshwater- and Seawater-Acclimated Milkfish, Chanos chanos - Chia-Hao Chang; Chia-Jui Liu; Wei-Jie Lu; Li-Yang Wu; Kuang-Jie Lai; Yu-Ting Lin; Tsung-Han Lee (Frontiers in Marine Science, 2022)
The milkfish, Chanos chanos , is an important aquaculture species that can be cultured in freshwater (FW) and seawater (SW) ponds because of its high euryhalinity. In winter, cold snap leading to high mortality of this tropical species is a critical issue for the aquaculture industry in Taiwan. Under hypothermal stress, however, changes in energy supply for osmoregulation of this euryhaline species is intriguing. In this study, we used an antibody against glycogen phosphorylase (GP) to identify glycogen-rich (GR) cells distributed adjacent to the mitochondria-rich (MR) ionocytes in milkfish gills. Glucose transporter 1 (GLUT1), which plays a major role in energy supply, was also identified and localized in GR cells. Moreover, the expression of indicators of aerobic metabolism and energy production, citrate synthase (CS) and cytochrome c oxidase (COX), were analyzed in gills of FW- and SW-acclimated milkfish to reveal different strategies of energy utilization under hypothermal stress. When exposed to a low-temperature environment, SW individuals used branchial glycogen and lactate to match the energy demands of aerobic metabolism in ionocytes, and elevated aerobic capacity to support and maintain normal functions in gills. However, branchial glycogen mainly localized in the GR cells of FW milkfish was not utilized under hypothermal stress. Meanwhile, a similar level of branchial COX activity and COXIV protein abundance at low temperatures between FW and SW milkfish indicated similar energy requirements in gills. This suggested that another source, but not branchial glycogen, maintained the energy demand in FW milkfish. The present study illustrated differential energy supply strategies in gills between SW- and FW-acclimated milkfish for osmoregulation under low temperatures.

Alleviation of salt stress and promotion of growth in peanut by Tsukamurella tyrosinosolvens and Burkholderia pyrrocinia - Yu Xu; Ying Li; Changmei Long; Lizhen Han (Biologia, 2022)

Pollution levels and toxicity risks of heavy metals in different reed wetland soils following channel diversion in the Yellow River Delta - Qiutang Wu; Fuhua Bian; Franziska Eller; Mengdi Wu; Guangxuan Han; Junbao Yu; Bo Guan (Wetlands, 2022)

Enhanced genome editing to ameliorate a genetic metabolic liver disease through co-delivery of adeno-associated virus receptor - Shuming Yin; Lie Ma; Tingting Shao; Mei Zhang; Yuting Guan; Liren Wang; Yaqiang Hu; Xi Chen; Honghui Han; Nan Shen; Wenjuan Qiu; Hongquan Geng; et al. (Science China Life Sciences, 2022)

Resistance of steppe communities to extreme drought in northeast China - Wang Ma; Xiaosa Liang; Zhengwen Wang; Wentao Luo; Qiang Yu; Xingguo Han (Plant and Soil, 2022)

Chronic and intense droughts differentially influence grassland carbon-nutrient dynamics along a natural aridity gradient - Wentao Luo; Xiaoan Zuo; Robert J. Griffin-Nolan; Chong Xu; Jordi Sardans; Qiang Yu; Zhengwen Wang; Xingguo Han; Josep Peñuelas (Plant and Soil, 2022)

Curcumin Inhibits Cell Damage and Apoptosis Caused by Thapsigargin-Induced Endoplasmic Reticulum Stress Involving the Recovery of Mitochondrial Function Mediated by Mitofusin-2 - He-Yan Zhou; Yu-Ying Sun; Ping Chang; Han-Chang Huang (Neurotoxicity Research, 2022)

Involvement of Opioid Peptides in the Analgesic Effect of Spinal Cord Stimulation in a Rat Model of Neuropathic Pain - Fu-Jun Zhai; Song-Ping Han; Tian-Jia Song; Ran Huo; Xing-Yu Lan; Rong Zhang; Ji-Sheng Han (Neuroscience Bulletin, 2022)

Altered Connectedness of the Brain Chronnectome During the Progression to Alzheimer’s Disease - Maryam Ghanbari; Zhen Zhou; Li-Ming Hsu; Ying Han; Yu Sun; Pew-Thian Yap; Han Zhang; Dinggang Shen (Neuroinformatics, 2022)

Exploring the Potential Antidepressant Mechanisms of Pinellia by Using the Network Pharmacology and Molecular Docking - Yu-Gang Xiao; Han-Biao Wu; Ji-Sheng Chen; Xiong Li; Zhi-Kun Qiu (Metabolic Brain Disease, 2022)

Application of the hydrothermally treated oxytetracycline fermentation residue in agriculture: concentrations of antibiotic and resistance genes in soil and plant - Mohammed Awad; Zhe Tian; Ziming Han; Xiao Luan; Yu Zhang; Min Yang; Liping Dong (Journal of Soils and Sediments, 2022)

Analysis of genotype–phenotype relationships in 90 Chinese probands with Waardenburg syndrome - Guojian Wang; Xiaohong Li; Xue Gao; Yu Su; Mingyu Han; Bo Gao; Chang Guo; Dongyang Kang; Shasha Huang; Yongyi Yuan; Pu Dai (Human Genetics, 2022)

Phthalate’s multiple hormonal effects and their supplementary dietary regulation scheme of health risks for children - Zhenzhen Han; Jiaqi Xue; Yu Li (Environmental Science and Pollution Research, 2022)

Application of exogenous glycinebetaine alleviates lead toxicity in pakchoi (Brassica chinensis L.) by promoting antioxidant enzymes and suppressing Pb accumulation - Yu Ji; Yanfang Ren; Chuan Han; Wenjia Zhu; jinyu Gu; Junyu He (Environmental Science and Pollution Research, 2022)

Rapid and sensitive detection of Karenia mikimotoi by loop-mediated isothermal amplification combined with a lateral flow dipstick - Xiaotian Han; Ting Zhao; Tian Yan; Rencheng Yu (Environmental Science and Pollution Research, 2022)

Lanthanum Impairs Learning and Memory by Activating Microglia in the Hippocampus of Mice - Licheng Yan; Jinghua Yang; Miao Yu; Wenchang Sun; Yarao Han; Xiaobo Lu; Cuihong Jin; Shengwen Wu; Yuan Cai (Biological Trace Element Research, 2022)

Overexpression of MxFRO6, a FRO gene from Malus xiaojinensis, increases iron and salt tolerance in Arabidopsis thaliana - Yingmei Li; Jiliang Zhong; Pengfei Huang; Bangtao Shao; Wenhui Li; Wanda Liu; Yu Wang; Liping Xie; Meina Han; Deguo Han (In Vitro Cellular & Developmental Biology - Plant, 2022)

Overexpression of MxWRKY53 increased iron and high salinity stress tolerance in Arabidopsis thaliana - Deguo Han; Tianlong Xu; Jiaxin Han; Wanda Liu; Yu Wang; Xingguo Li; Xiaohan Sun; Xinhui Wang; Tiemei Li; Guohui Yang (In Vitro Cellular & Developmental Biology - Plant, 2022)

Correction to: Role of HMGB1 in TNF-α Combined with Z-VAD-fmk-Induced L929 Cells Necroptosis - Zhao Lei; Can Yu; Xia Li; Li-Hua Huang; Zhi-Qiang Li; Hong-Wei Zhu; Duo Han; Hui Huang; Xiao Yu (Biochemical Genetics, 2022)

Role of HMGB1 in TNF-α Combined with Z-VAD-fmk-Induced L929 Cells Necroptosis - Can Yu; Zhao Lei; Xia Li; Li-Hua Huang; Zhi-Qiang Li; Hong-Wei Zhu; Duo Han; Hui Huang; Xiao Yu (Biochemical Genetics, 2022)

Influence of rock bridge length on geomechanical behaviors of granite containing a hole and fissures under uniaxial increasing-amplitude decreasing-frequency cyclic loads - Yu Wang; Dayu Long; Jianqiang Han (Arabian Journal of Geosciences, 2022)

The significance of riparian communities in the energy flow of subtropical stream ecosystems - Yi-Chang Liao; An-Cheng Lin; Han-Ni Tsai; Yu-Ting Yen; Chyng-Shyan Tzeng; Man-Miao Yang; Hsing-Juh Lin (Aquatic Sciences, 2022)

Expansion of bilin‐based red light sensors in the subaerial desert cyanobacterium Nostoc flagelliforme - Hai‐Feng Xu; Guo‐Zheng Dai; Yu‐Jie Wang; Chao Cheng; Jin‐Long Shang; Ren‐Han Li; Ke Liu; Deqiang Duanmu; Bao‐Sheng Qiu (Environmental Microbiology, 2022)
Summary Light is the crucial environmental signal for desiccation‐tolerant cyanobacteria to activate photosynthesis and prepare for desiccation at dawn. However, the photobiological characteristics of desert cyanobacteria adaptation to one of the harshest habitats on Earth remain unresolved. In this study, we surveyed the genome of a subaerial desert cyanobacterium Nostoc flagelliforme and identified two phytochromes and seven cyanobacteriochromes (CBCRs) with one or more bilin‐binding GAF (cGMP phosphodiesterase/adenylyl cyclase/FhlA) domains. Biochemical and spectroscopic analyses of 69 purified GAF‐containing proteins from recombinant phycocyanobilin (PCB), biliverdin or phycoerythrobilin‐producing Escherichia coli indicated that nine of these proteins bind chromophores. Further investigation revealed that 11 GAFs form covalent adducts responsive to near‐UV and visible light: eight GAFs contained PCB chromophores, three GAFs contained biliverdin chromophores and one contained the PCB isomer, phycoviolobilin. Interestingly, COO91_03972 is the first‐ever reported GAF‐only CBCR capable of sensing five wavelengths of light. Bioinformatics and biochemical analyses revealed that residue P132 of COO91_03972 is essential for chromophore binding to dual‐cysteine CBCRs. Furthermore, the complement of N . flagelliforme CBCRs is enriched in red light sensors. We hypothesize that these sensors are critical for the acclimatization of N . flagelliforme to weak light environments at dawn.

Unexpected role of electron‐transfer hub in direct degradation of pollutants by exoelectrogenic bacteria - Ting‐Ting Zhu; Zhou‐Hua Cheng; Sheng‐Song Yu; Wen‐Wei Li; Dong‐Feng Liu; Han‐Qing Yu (Environmental Microbiology, 2022)
Summary Exoelectrogenic bacteria (EEB) are capable of anaerobic respiration with diverse extracellular electron acceptors including insoluble minerals, electrodes and flavins, but the detailed electron transfer pathways and reaction mechanisms remain elusive. Here, we discover that CymA, which is usually considered to solely serve as an inner‐membrane electron transfer hub in Shewanella oneidensis MR‐1 (a model EEB), might also function as a reductase for direct reducing diverse nitroaromatic compounds (e.g. 2,4‐dichloronitrobenzene) and azo dyes. Such a process can be accelerated by dosing anthraquinone‐2,6‐disulfonate. The CymA‐based reduction pathways in S . oneidensis MR‐1 for different contaminants could be functionally reconstructed and strengthened in Escherichia coli . The direct reduction of lowly polar contaminants by quinol oxidases like CymA homologues might be universal in diverse microbes. This work offers new insights into the pollutant reduction mechanisms of EEB and unveils a new function of CymA to act as a terminal reductase.

Phytoplankton Species Diversity Patterns and Associated Driving Factors in China’s Jiulong River Estuary: Roles That Nutrients and Nutrient Ratios Play - Feiyang Ge; Zhiyuan Ma; Bin Chen; Yu Wang; Xiaoqian Lu; Shenqun An; Dian Zhang; Wanting Zhang; Weiwei Yu; Wenxuan Han; Xingguang Yu; Zhenghua Liu; et al. (Frontiers in Marine Science, 2022)
Understanding diversity patterns and associated driving factors are the critical topics in macroecology and conservation biology. Phytoplankton are highly susceptible to environmental changes in estuaries, particularly eutrophication. This study examined phytoplankton alpha and beta diversity using investigation data in May (springtime), August (summer) and November (autumn) 2009 in China’s Jiulong River estuary, where it was easily polluted because of considerable discharge from a highly dense human population and low self-purification capacity with its limited river basin area, potentially resulting in eutrophication and then influencing phytoplankton diversity. Potential influencing factors were also explored, including dissolved oxygen, salinity, nutrients, nutrient ratios, geographic and hydrologic distance, and so on. The results indicated that Shannon’s index ( H’ ) and Pielou’s index ( J ) decreased from the estuary’s upper to middle and then increased from middle to lower reaches, Simpson’s ( D ) observed the opposite trend and species number ( S ) gradually increased from the estuary’s upper to lower reaches. For beta diversity, all the indices showed a gradual decrease trend from the estuary’s upper to lower reaches, where also, turnover dominated beta diversity for all seasons. It is noteworthy that the significant roles that nutrients and nutrient ratios played in shaping phytoplankton diversity patterns and the nutrient balance were characterized by excess nitrogen (N) and silicon (Si) and limited phosphorus (P), which could potentially cause diatom blooms. Findings also showed that decreasing Si concentrations can help to reduce overall pollution levels as well as the restoration of the estuary’s ecosystem better than just reducing N alone. Accordingly, this study advocates for the protection of the entire estuary system with particular emphasis on its upper reaches. Moreover, greater attention should also be paid to impacts associated with N input and nutrient ratio trade-offs to the prospective watershed management of this estuary. This study provides a practical approach to explore estuarine diversity in a comprehensive way, which can inform effective biodiversity conservation and also be applied to other marine ecosystems to better guide sustainable management and conservation practices.

Screening and identification of HLA-A2-restricted neoepitopes for immunotherapy of non-microsatellite instability-high colorectal cancer - Ranran Shi; Yubing Li; Ling Ran; Yu Dong; Xiuman Zhou; Jingwen Tang; Lu Han; Mingshuang Wang; Liwei Pang; Yuanming Qi; Yahong Wu; Yanfeng Gao (Science China Life Sciences, 2022)

Baicalin attenuates amyloid β oligomers induced memory deficits and mitochondria fragmentation through regulation of PDE-PKA-Drp1 signalling - Hai-Yang Yu; Ye Zhu; Xin-Li Zhang; Lei Wang; Yan-Meng Zhou; Fang-Fang Zhang; Han-Ting Zhang; Xiao-Min Zhao (Psychopharmacology, 2022)

Polysaccharide Krestin Prevents Alzheimer’s Disease-type Pathology and Cognitive Deficits by Enhancing Monocyte Amyloid-β Processing - Si-Han Chen; Chen-Yang He; Ying-Ying Shen; Gui-Hua Zeng; Ding-Yuan Tian; Yuan Cheng; Man-Yu Xu; Dong-Yu Fan; Cheng-Rong Tan; An-Yu Shi; Xian-Le Bu; Yan-Jiang Wang (Neuroscience Bulletin, 2022)

Analysis of Influencing Factors of Temperature Field in Freezing Construction of Metro Connecting Passage - Ping Xu; Shuqi Han; Yu Xing (Geotechnical and Geological Engineering, 2022)

QTL mapping integrated with BSA-Seq analysis identifies a novel gene conferring resistance to brown planthopper from common wild rice (Oryza rufipogon Griff.) - Xuan Wang; Yue Han; Yue-xiong Zhang; Biao Deng; Bi-qiu Wu; Xin-ying Guo; Yu-fen Qin; Yao-yu Fang; Fang Liu; Bao-xiang Qin; Ji-jing Luo; Rong-bai Li (Euphytica, 2022)

Effects of anthropogenic activities on hydrochemical characteristics of ground water of Da’an irrigation area in Western of Jilin Province - Zhiqi Gu; Jianmin Bian; Juanjuan Wu; Dongmei Ruan; Yexiang Yu; Han Zhang (Environmental Science and Pollution Research, 2022)

Cr release after Cr(III) and Cr(VI) enrichment from different layers of cast iron corrosion scales in drinking water distribution systems: the impact of pH, temperature, sulfate, and chloride - Yimei Tian; Tiantian Yu; Jingyi Shen; Guolei Zheng; Han Li; Weigao Zhao (Environmental Science and Pollution Research, 2022)

Electrochemically activated peroxymonosulfate for the abatement of chloramphenicol in water: performance and mechanism - Yu-Qiong Gao; Jin-Qiang Zhou; Han Ning; Yan-Yan Rao; Nai-Yun Gao (Environmental Science and Pollution Research, 2022)

Construction of cleaner production management system in China: mode innovation of cleaner production - Han Yu; Yinglun Zhao; Nan Yang; Zhicheng Pan; Hongbing Yu (Environmental Science and Pollution Research, 2022)

An investigation on the promoting effect of Pr modification on SO2 resistance over MnOx catalysts for selective reduction of NO with NH3 - Guangpeng Zhai; Zhitao Han; Huan Du; Yu Gao; Xinxiang Pan (Environmental Science and Pollution Research, 2022)

Distribution, bioavailability, and human health risk assessment of arsenic in groundwater-soil-rice system in the Jianghan Plain, Central China - Haotian Yu; Teng Ma; Yao Du; Shuai Shen; Zhihui Han (Environmental Science and Pollution Research, 2022)

The adaptation mechanism based on an integrated vulnerability assessment of potato production to climate change in Inner Mongolia, China - Na Huang; Jialin Wang; Yu Song; Yuying Pan; Guolin Han; Ziyuan Zhang; Shangqian Ma; Guofeng Sun; Cong Liu; Zhihua Pan (Mitigation and Adaptation Strategies for Global Change, 2022)

Rapid visual detection of Micropterus salmoides rhabdovirus using recombinase polymerase amplification combined with lateral flow dipsticks - Zizhao Feng; Xin Chu; Minzhen Han; Chenwei Yu; Yousheng Jiang; Hao Wang; Liqun Lu; Dan Xu (Journal of Fish Diseases, 2022)
Largemouth bass ( Micropterus salmoides ) is an important freshwater‐cultured species in China. Recently, a lethal and epidemic disease caused by Micropterus salmoides rhabdovirus (MSRV) results in huge economic losses to the largemouth bass industry. Current diagnostics for detecting MSRV are limited in sensitivity and speed and are inconvenient to be used for non‐laboratory detection. In this study, three rapid and convenient detection assays of MSRV by recombinase polymerase amplification (RPA) and lateral flow dipsticks (LFD), targeting the conserved sequences of the MSRV‐SS N gene, are described. With these RPA methods, the detection could achieve within 50 min at 38°C. Both methods of RPA‐AGE and RPA‐LFD could detect the viral DNA as low as 170 copies/μl of the MSRV standard plasmid and were 100‐fold more sensitive than that in the method of routine PCR. Meanwhile, these RPA methods were highly specific for the detection of MSRV and can be feasibly applied to the diagnostic of MSRV infection. In brief, RPA‐AGE, RPA‐LFD and RT‐RPA‐LFD provide convenient, rapid, sensitive and reliable methods that could improve field diagnosis of MSRV with limited machine resources, and would enhance the production of largemouth bass.

Prevalence, complete genome, and metabolic potentials of a phylogenetically novel cyanobacterial symbiont in the coral‐killing sponge, Terpios hoshinota - Yu‐Hsiang Chen; Hsing‐Ju Chen; Cheng‐Yu Yang; Jia‐Ho Shiu; Daphne Z. Hoh; Pei‐Wen Chiang; Wenhua Savanna Chow; Chaolun Allen Chen; Tin‐Han Shih; Szu‐Hsien Lin; Chi‐Ming Yang; James Davis Reimer; et al. (Environmental Microbiology, 2022)
Summary Terpios hoshinota is an aggressive, space‐competing sponge that kills various stony corals. Outbreaks of this species have led to intense damage to coral reefs in many locations. Here, the first large‐scale 16S rRNA gene survey across three oceans revealed that bacteria related to the taxa Prochloron , Endozoicomonas , SAR116, Ruegeria , and unclassified Proteobacteria were prevalent in T . hoshinota . A Prochloron ‐related bacterium was the most dominant and prevalent cyanobacterium in T . hoshinota . The complete genome of this uncultivated cyanobacterium and pigment analysis demonstrated that it has phycobiliproteins and lacks chlorophyll b , which is inconsistent with the definition of Prochloron . Furthermore, the cyanobacterium was phylogenetically distinct from Prochloron , strongly suggesting that it should be a sister taxon to Prochloron . Therefore, we proposed this symbiotic cyanobacterium as a novel species under the new genus Candidatus Paraprochloron terpiosi. Comparative genomic analyses revealed that ‘Paraprochloron’ and Prochloron exhibit distinct genomic features and DNA replication machinery. We also characterized the metabolic potentials of ‘Paraprochloron terpiosi’ in carbon and nitrogen cycling and propose a model for interactions between it and T. hoshinota . This study builds a foundation for the study of the T . hoshinota microbiome and paves the way for better understanding of ecosystems involving this coral‐killing sponge.

Propagation and Separation of Downslope Gravity Currents over Rigid and Emergent Vegetation Patches in Linearly Stratified Environments - Ying-Tien Lin; Yi-Qi Ye; Dong-Rui Han; Yu-Jia Chiu (Journal of Marine Science and Engineering, 2022)
Large eddy simulation (combined with the mixture model) and laboratory experiment were used to investigate the impact of emergent and rigid vegetation on the dynamics of downslope gravity currents in stratified environments. The reliability of the numerical model was assessed with the corresponding laboratory measurements. The results show that the vegetation cylinders lead to severe lateral non-uniformity of the current front, causing more evident lobe and cleft structures. In stratified environments, the smaller driving force leads to less propagating velocity until the current separates from the slope. The transition point (from acceleration to deceleration phases) of current velocity appears earlier as the vegetation becomes denser. The peak value of the bulk entrainment coefficient Ebuik is inversely proportional to the vegetation density, while the final converged value of Ebuik is proportional to the vegetation density. Vegetation patches make the degree of fluctuation of the instantaneous entrainment coefficient Einst more intense, and even negative values appear locally, indicating that the gravity current is detrained into the ambient fluid. The velocity profiles of gravity current develop multi-peak patterns in stratified environments due to fingering intrusive patterns. Our analysis reveals that as the vegetation density increases, the generated wakes behind vegetation cylinders increase local entrainment and mixing, causing the density of current flow from vegetation to decrease and reach the neutral buoyancy layer of ambient fluids earlier, finally leading to a smaller separation depth.

Phylogeography and Genetic Structure of the Swimming Crabs Portunus sanguinolentus (Herbst, 1783) in East Asia - Yu-Ming Lu; Chun-Han Shih; Po-Cheng Chen; Wei-Chieh Kao; Ying-Chou Lee; Yu-San Han; Tzong-Der Tzeng (Journal of Marine Science and Engineering, 2022)
The three-spot swimming crab (Portunus sanguinolentus) is mainly distributed in South East Asia. An analysis of mitochondrial control region partial sequences allows us to determine the population genetic structure, phylogeography and historical demography of this species in East Asia. The seven populations, which included 110 individuals, were collected from mainland China (Shanghai, SH, Xiamen, XM and Hong Kong, HK), Taiwan (Yilan, YL, Taichung, TC, Donggang, DG) and Singapore (Singapore, SGP). The nucleotide diversity (π) of all individuals was 0.01149, with values ranging from 0.00372 (SGP) to 0.01345 (YL). In total, 90 haplotypes have been identified, which can be divided into two major lineages: lineage A consists of specimens from SH, YL, XM, TC and DG, and lineage B corresponds to specimen from SGP. From the second to the most recent interglacial period, population expansion was observed in each lineage. However, a low level of genetic differentiation was also observed in the three-spotted swimming crab, P. sanguinolentus, according to FST values. Our results suggest that several past and present habitat configurations have shaped the genetic patterns of P. sanguinolentus until now. During Pleistocene glaciations, when sea levels were low, this species may have moved along the coast from Southeast Asia to China. It first colonized the Hong Kong area during this era. After sea levels rose and shorelines receded, it subsequently spread to the coast of mainland China.

Bacteria-based nanosystems for enhanced antitumor therapy - Yu Han; Miao Fan; Dandan Han; Kun Ge; Jin Chang; Jinchao Zhang (Science China Life Sciences, 2022)

Mechanism of interactions between α-conotoxin RegIIA and carbohydrates at the human α3β4 nicotinic acetylcholine receptor - Meiling Zheng; Han-Shen Tae; Liang Xue; Tao Jiang; Rilei Yu (Marine Life Science & Technology, 2022)
Conotoxins are marine peptide toxins from marine cone snails. The α-conotoxin RegIIA can selectively act on human (h) α3β4 nicotinic acetylcholine receptor (nAChR), and is an important lead for drug development. The high-resolution cryo-electron microscopy structure of the α3β4 nAChR demonstrates several carbohydrates are located near the orthosteric binding sites, which may affect α-conotoxin binding. Oligosaccharide chains can modify the physical and chemical properties of proteins by changing the conformation, hydrophobicity, quality and size of the protein. The purpose of this study is to explore the effect of oligosaccharide chains on the binding modes and activities of RegIIA and its derivatives at hα3β4 nAChRs. Through computational simulations, we designed and synthesized RegIIA mutants at position 14 to explore the importance of residue H14 to the activity of the peptide. Molecular dynamics simulations suggest that the oligosaccharide chains affect the binding of RegIIA at the hα3β4 nAChR through direct interactions with H14 and by affecting the C-loop conformation of the binding sites. Electrophysiology studies on H14 analogues suggest that in addition to forming direct interactions with the carbohydrates, the residue might play an important role in maintaining the conformation of the peptide. Overall, this study further clarifies the structure–activity relationship of α-conotoxin RegIIA at the hα3β4 nAChR and, also provides important experimental and theoretical basis for the development of new peptide drugs.

First report of a crinivirus infecting mulberry (Morus alba L.) in China - Peng Zhang; Yu Ma; Tao-Tao Han; William Kojo Smith; Jing Yu; Yong-Yuan Cheng; Quan-You Lu (Journal of Plant Pathology, 2022)

An Accurate Segmentation Framework for Static Ultrasound Images of the Gestational Sac - Chenghuan Yin; Yu Wang; Qixin Zhang; Fangfang Han; Zhengwei Yuan; Yudong Yao (Journal of Medical and Biological Engineering, 2022)

Leveraging sustainable development of agriculture with sustainable water management: The empirical investigation of “Five Water Cohabitation” of Zhejiang Province in China - Jiaqi Tian; Yunyan Han; Jinhui Shen; Yu Zhu (Environmental Monitoring and Assessment, 2022)

The lining responses for shallow mountain tunnels subjected to frost heaving - Xian-zhang Ling; Yuan Yu; Liang Tang; Lin Geng; Xiao Han (Journal of Mountain Science, 2022)

GATA4 Is a Transcriptional Regulator of SOX2 in Japanese Flounder (Paralichthys olivaceus) - Xiumei Liu; Zan Li; Weijie Yan; Haitao Zhao; Yuxiang Liu; Miao Han; Xubo Wang; Yan He; Haiyang Yu; Quanqi Zhang (Journal of Ocean University of China, 2022)

Mesenchymal-to-epithelial transition of osteoblasts induced by Fam20c knockout - Ya-Wei Geng; Zhen Zhang; Han Jin; Jun-Long Da; Kai Zhang; Jian-Qun Wang; Yu-Yao Guo; Bin Zhang; Ying Li (Genes & Genomics, 2022)

Comparative phylogeography of Acanthocalyx (Caprifoliaceae) reveals distinct genetic structures in the Himalaya–Hengduan Mountains - Qi-Yong Mu; Chih-Chieh Yu; Yan Wang; Ting-Shen Han; Hui Wang; Wen-Na Ding; Qiu-Yue Zhang; Shook Ling Low; Quan-Jing Zheng; Chuan Peng; Zheng-Yan Hu; Yao-Wu Xing (Alpine Botany, 2022)

Research on hoop capacity of composite foundation of discarded rubber tires - Feng-Chi Wang; Jun Li; Zhen-Huan Lin; Pei-Pei Tian; Han-Yu Zhao (European Journal of Environmental and Civil Engineering, 2022)

A new N -containing phenolic glycoside from Capsicum annuum L. - Changwei Song; Changyan Yu; Xinting Zhu; Xirong Luo; Yong Zhang; Lingjie Meng; Yong Luo; Han Chang; Cheng Qin; Yun Liu (Natural Product Research, 2022)

Current Dependent Dispersal Characteristics of Japanese Glass Eel around Taiwan - Kuan-Mei Hsiung; Yen-Ting Lin; Yu-San Han (Journal of Marine Science and Engineering, 2022)
Japanese eel larvae are passively transported to the East Asian Continental Shelf by the North Equatorial Current, Kuroshio and Kuroshio intrusion currents, and coastal currents. Previous studies have investigated the dispersal characteristics and pathways of Japanese glass eels. However, there are still limitations in these studies. According to long-term (2010–2020) catch data from the Fisheries Agency in Taiwan, the distribution and time series of glass eels recruitment to Taiwan are closely related to the surrounding ocean currents. Recruitment begins in eastern Taiwan via the mainstream Kuroshio and in southern Taiwan via the Taiwan Strait Warm Current. In central Taiwan, recruitment occurs from southern Taiwan, as well as from mainland China via the southern branch of the China Coast Current (CCC). The latest recruitment occurred in northern Taiwan and mainly comprised glass eels from mainland China via the northern branch of the CCC. A stronger monsoon during the La Niña phase could affect the recruitment time series in northern and eastern Taiwan. This study suggests that the recruitment directionality of glass eels is an indicator of the flow field of ocean/coastal currents and elucidates the dispersal characteristics of glass eels in the waters around Taiwan.

Two new nor -lignans from Selaginella pulvinata (Hook. & Grev.) Maxim and their antihyperglycemic activities - Hua-Wei Lv; Yu-Xia Li; Meng Luo; Jia-Meng Qi; Ze-Fei Fu; Hong-Jian Zhang; Yuan-Qiang Guo; Chu Chu; Han-Bing Li; Ji-Zhong Yan (Natural Product Research, 2022)

Nanofiltration Membrane Fouling and Control Caused by Residual Aluminum in Feed Water - Hui-Bo Yu; Xian-Qiu Zhang; Xue Han; Zhen-Zhen Yang; Ya-Wen Zhou; Wen Ding; Ming-Xia Du (Water, Air, & Soil Pollution, 2022)

Enhanced stripe rust resistance obtained by combining Yr30 with a widely dispersed, consistent QTL on chromosome arm 4BL - Shengjie Liu; Xiaoting Wang; Yayun Zhang; Yangang Jin; Zhonghua Xia; Mingjie Xiang; Shuo Huang; Linyi Qiao; Weijun Zheng; Qingdong Zeng; Qilin Wang; Rui Yu; et al. (Theoretical and Applied Genetics, 2022)

Distinct durability of IgM/IgG antibody responses in COVID-19 patients with differing severity - Junyan Han; Ning Zhang; Danying Chen; Yuhuan Gong; Guoli Li; Yaxian Kong; Lin Pu; Chen Chen; Jingyuan Liu; Qi Wang; Ju Zhang; Xuesen Zhao; et al. (Science China Life Sciences, 2022)

The complete plastomes of red fleshed pitaya (Selenicereus monacanthus) and three related Selenicereus species: insights into gene losses, inverted repeat expansions and phylogenomic implications - Qiulin Qin; Jingling Li; Siyuan Zeng; Yiceng Xu; Fang Han; Jie Yu (Physiology and Molecular Biology of Plants, 2022)

The phenolic acids from Oplopanax elatus Nakai stems and their potential photo-damage prevention activity - Yu Han; Dongsheng Cheng; Mimi Hao; Jiejing Yan; Jingya Ruan; Lifeng Han; Yi Zhang; Tao Wang (Journal of Natural Medicines, 2022)

Comparative profiling of genome-wide small RNAs in non-heading Chinese cabbage [Brassica rapa subsp. chinensis (L.) Hanelt] - Xuxin Liu; Xiang Yu; Han Wang; Yuke He (Genetic Resources and Crop Evolution, 2022)

Subjective visual vertical imprecision during lateral head tilt in patients with chronic dizziness - Ariel A. Winnick; Chia-Han Wang; Yu-Hung Ko; Tzu-Pu Chang (Experimental Brain Research, 2022)

The adaptability of Phytophthora sojae to different types of soil determines the distribution of Phytophthora root rot of soybean in Heilongjiang Province of China - Haixu Liu; Han Yu; Zhuoqun Zhang; Xiangqi Bi; Zhiyue Yang; Yufei Chen; Xin Gu; Jingzhi Wen (European Journal of Plant Pathology, 2022)

A cooperative game model with bankruptcy theory for water allocation: a case study in China Tarim River Basin - Jiahe Tian; Yang Yu; Tongshu Li; Yi Zhou; Jingjun Li; Xingpeng Wang; Yu Han (Environmental Science and Pollution Research, 2022)

Characterization of a strong constitutive promoter from paper mulberry vein banding virus - William K. Smith; Yu Ma; Jing Yu; Yong-Yuan Cheng; Peng Zhang; Tao-Tao Han; Quan-You Lu (Archives of Virology, 2022)

Alteribacter salitolerans sp. nov., isolated from a saline-alkaline soil - Shuang Wang; Lei Sun; Manik Prabhu Narsing Rao; Guo-Hong Liu; Pin-Jiao Jin; Zhou-Yan Dong; Zheng-Han Lian; Xiao-Yu Hao; Ming-Yi Zhang; Wen-Jun Li (Archives of Microbiology, 2022)

Maribellus maritimus sp. nov., isolated from marine sediment - Yu-Qi Ye; Ze-Tian Han; Xin-Jiang Liu; Meng-Qi Ye; Zong-Jun Du (Archives of Microbiology, 2022)

Geochemical characteristics and origin of Chang-9 crude oil of Triassic Yanchang Formation in Zhidan area, Ordos Basin, China - Zhengyu Wu; Shijia Chen; Chengshan Li; Jian Yu; Yibo Chang; Zixing Lu; Xin He; Haifeng Zhang; Han Meimei (Arabian Journal of Geosciences, 2022)

Biodiversity alleviates the decrease of grassland multifunctionality under grazing disturbance: A global meta‐analysis - Ruiyang Zhang; Dashuan Tian; Han Y. H. Chen; Eric W. Seabloom; Guodong Han; Shaopeng Wang; Guirui Yu; Zhaolei Li; Shuli Niu (Global Ecology and Biogeography, 2022)
Aim Biodiversity drives the delivery of multiple ecosystem functions related to carbon and nutrient cycling (ecosystem multifunctionality, EMF), and biodiversity and ecosystem functioning are strongly threatened by intensive grazing in grasslands. However, it remains unclear how biodiversity regulates EMF changes in response to intensive grazing. Location Global. Time period From 1992 to 2018. Major taxa studied Grassland. Methods Here, we conducted a global synthesis using 373 paired observations from 90 published studies to address the responses of plant diversity, EMF and their relationships to grazing disturbance depending on grazing intensity, livestock type, grazing duration, and climatic aridity. Results Our results showed that EMF significantly decreased with increasing grazing intensity, but the negative EMF response was alleviated at high levels of plant diversity. The grazing‐induced changes in EMF increased linearly with the changes in plant diversity, with the slopes increasing by 78.9% from light to heavy grazing. In addition, the grazing‐induced decrease of EMF was stronger with longer grazing duration and more arid climates. Structural equation models suggested that grazing intensity reduced EMF largely via decreasing plant diversity, whereas upsizing livestock type promoted EMF by increasing plant diversity. Main conclusions This study highlights the key role of biodiversity in mediating EMF in response to intensifying grazing disturbance. We call for conservation of biodiversity to maintain grassland multifunctionality and services.

The brown root rot fungus Phellinus noxius affects microbial communities in different root‐associated niches of Ficus trees - Tse‐Yen Liu; Chao‐Han Chen; Yu‐Liang Yang; Isheng J. Tsai; Ying‐Ning Ho; Chia‐Lin Chung (Environmental Microbiology, 2022)
Summary Brown root rot (BRR) caused by Phellinus noxius is a destructive tree disease in tropical and subtropical areas. To understand how BRR affects the composition of the plant rhizoplane‐enriched microbiota, the microbiomes within five root‐associated compartments (i.e., bulk soil, old/young root rhizosphere soil, old/young root tissue) of Ficus trees naturally infected by P. noxius were investigated. The level of P. noxius infection was determined by quantitative PCR. Illumina sequencing of the internal transcribed spacer and 16S rRNA revealed that P. noxius infection caused a significant reduction in fungal diversity in the bulk soil, the old root rhizosphere soil, and the old root tissue. Interestingly, Cosmospora was the only fungal genus positively correlated with P. noxius . The abundance and composition of dominant bacterial taxa such as Actinomadura , Bacillus , Rhodoplanes , and Streptomyces differed between BRR‐diseased and healthy samples. Furthermore, 838 isolates belonging to 26 fungal and 35 bacterial genera were isolated and tested for interactions with P. noxius . Antagonistic activities were observed for isolates of Bacillus , Pseudomonas , Aspergillus , Penicillium , and Trichoderma . Cellophane overlay and cellulose/lignin utilization assays suggested that Cosmospora could tolerate the secretions of P. noxius and that the degradation of lignin by P. noxius may create suitable conditions for Cosmorpora growth.

Kinetics and Size Effects on Adsorption of Cu(II), Cr(III), and Pb(II) Onto Polyethylene, Polypropylene, and Polyethylene Terephthalate Microplastic Particles - Xiaoxin Han; Shiyu Wang; Xue Yu; Rolf D. Vogt; Jianfeng Feng; Lifang Zhai; Weiqi Ma; Lin Zhu; Xueqiang Lu (Frontiers in Marine Science, 2021)
Due to its small size, large specific surface area and hydrophobicity, microplastics, and the adsorbed contaminants may together cause potential negative effects on ecosystems and human beings. In this study, kinetics and size effects on adsorption of Cu(II), Cr(III), and Pb(II) onto PE, PP and PET microplastic particles were explored. Results indicated that the PE and PET microplastics have the higher adsorption capacity for Cu(II), Cr(III), and Pb(II) than that for PP microplastic. The adsorption capacity was affected by microplastic types and metal species. Among the three metals, Pb(II) had the largest adsorption amount on microplastic particles, especially on PET particles. Moreover, the adsorption capacities of microplastics increase with the decrease of particle size. The metal adsorption capacity of <0.9 mm microplastics is greater than that of 0.9–2 mm and 2–5 mm microplastics. The size effect on metal adsorption was largest for PE microplastic. More attention should be paid in case of the coexistence of heavy metals and tiny PE and PET microplastics in the environment.

MdKCS2 increased plant drought resistance by regulating wax biosynthesis - Xin-Yu Lian; Huai-Na Gao; Han Jiang; Chang Liu; Yuan-Yuan Li (Plant Cell Reports, 2021)

Photosynthetic acclimation during low-light-induced leaf senescence in post-anthesis maize plants - Han-Yu Wu; Li-An Liu; Lei Shi; Wang-Feng Zhang; Chuang-Dao Jiang (Photosynthesis Research, 2021)

miR-451-3p alleviates myocardial ischemia/reperfusion injury by inhibiting MAP1LC3B-mediated autophagy - Xiang-Wei Lv; Zi-Feng He; Pan-Pan Zhu; Qiu-Yu Qin; Yun-Xue Han; Tong-Tong Xu (Inflammation Research, 2021)

Effects of industrial agglomeration and environmental regulation on urban ecological efficiency: evidence from 269 cities in China - Yizhen Zhang; Han Zhang; Yu Fu; Luwei Wang; Tao Wang (Environmental Science and Pollution Research, 2021)

Association between ozone exposure and prevalence of mumps: a time-series study in a Megacity of Southwest China - Wenjun Xie; Han Zhao; Chang Shu; Bin Wang; Wen Zeng; Yu Zhan (Environmental Science and Pollution Research, 2021)

Comparing the effects of plant diversity on the nitrogen removal and stability in floating and sand-based constructed wetlands under ammonium/nitrate ratio disturbance - Yuanyuan Du; Shaodan Niu; Hang Jiang; Bin Luo; Qian Wang; Wenjuan Han; Yu Liu; Jie Chang; Ying Ge (Environmental Science and Pollution Research, 2021)

Genome sequence analysis of Cronobacter phage PF-CE2 and proposal of a new species in the genus Pseudotevenvirus - Mengshi Xiao; Xinmiao Ren; Ying Yu; Han Sun; Haijin Mou; Xiaodan Fu (Archives of Virology, 2021)

Retraction Note to: Soil erosion and regional industrial upgrading in the Yangtze River surrounding area based on ecological evaluation - Yu Jiajia; Han Yuqi; Gao Qian (Arabian Journal of Geosciences, 2021)

SBAS-InSAR time series ground subsidence monitoring along Metro Line 13 in Qingdao, China - Qiuxiang Tao; Zaijie Guo; Fengyun Wang; Qingguo An; Yu Han (Arabian Journal of Geosciences, 2021)

Correction to: AGGF1 protects from myocardial ischemia/reperfusion injury by regulating myocardial apoptosis and angiogenesis - Yu Liu; Hui Yang; Lina Song; Nan Li; Qiu-Yue Han; Cui Tian; Erhe Gao; Jie Du; Yun-Long Xia; Hui-Hua Li (Apoptosis, 2021)

On the Second-Year Warming in Late 2019 over the Tropical Pacific and Its Attribution to an Indian Ocean Dipole Event - Licheng Feng; Fei Liu; Rong-Hua Zhang; Xue Han; Bo Yu; Chuan Gao (Advances in Atmospheric Sciences, 2021)

Controlling pathogenic risks of water treatment biotechnologies at the source by genetic editing means - Jie Wu; Dong‐Feng Liu; Hui‐Hui Li; Di Min; Jia‐Qi Liu; Peng Xu; Wen‐Wei Li; Han‐Qing Yu; Yong‐Guan Zhu (Environmental Microbiology, 2021)
Summary Antimicrobial‐resistant pathogens in the environment and wastewater treatment systems, many of which are also important pollutant degraders and are difficult to control by traditional disinfection approaches, have become an unprecedented treat to ecological security and human health. Here, we propose the adoption of genetic editing techniques as a highly targeted, efficient and simple tool to control the risks of environmental pathogens at the source. An ‘all‐in‐one’ plasmid system was constructed in Aeromonas hydrophila to accurately identify and selectively inactivate multiple key virulence factor genes and antibiotic resistance genes via base editing, enabling significantly suppressed bacterial virulence and resistance without impairing their normal phenotype and pollutant‐degradation functions. Its safe application for bioaugmented treatment of synthetic textile wastewater was also demonstrated. This genetic‐editing technique may offer a promising solution to control the health risks of environmental microorganisms via targeted gene inactivation, thereby facilitating safer application of water treatment biotechnologies.

Three new diterpenoids from Euphorbia peplus - Yan-Ni Chen; Qing-Yun Lu; Dong-Mei Li; Ying-Yao Li; Xue-Xue Pu; Bo-Ting Li; Xiao-Han Tang; Hong-Yu Tang; Shuai Liu; Lei Yang; Yu Zhang; Ying-Tong Di; et al. (Natural Product Research, 2021)

A New Instrumental Array in Sichuan, China, to Monitor Vibrations and Perturbations of the Lithosphere, Atmosphere, and Ionosphere - Chieh-Hung Chen; Yang-Yi Sun; Kai Lin; Chen Zhou; Rui Xu; Haiyin Qing; Yongxin Gao; Tao Chen; Fei Wang; Huaizhong Yu; Peng Han; Chi-Chia Tang; et al. (Surveys in Geophysics, 2021)

Loganin ameliorates depression-like behaviors of mice via modulation of serotoninergic system - Chen-Hao Pan; Cong-Yuan Xia; Yu Yan; Yan Han; Rui Shi; Jun He; Ze-Xing Wang; Yu-Ming Wang; Wei-Ku Zhang; Jie-Kun Xu (Psychopharmacology, 2021)

Lipin1 Alleviates Autophagy Disorder in Sciatic Nerve and Improves Diabetic Peripheral Neuropathy - Meijian Wang; Min Xie; Shuyan Yu; Pan Shang; Cong Zhang; Xiaolin Han; Cuiqin Fan; Li Chen; Xianghua Zhuang; Shihong Chen (Molecular Neurobiology, 2021)

TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain - Lu Wang; Han-Yu Yang; Cai-Xia Zang; Jun-Mei Shang; Hui Liu; Zi-Hong Zhang; Fang-Yu Yuan; Cheng Ju; Fang-Yuan Li; Xiu-Qi Bao; Dan Zhang (Molecular Neurobiology, 2021)

Drivers of changes in soil properties during post-fire succession on Dahurian larch forest - Yuetai Weng; Zhaoguo Li; Sisheng Luo; Zhangwen Su; Xueying Di; Guang Yang; Hongzhou Yu; Dongdong Han (Journal of Soils and Sediments, 2021)

Characteristics of ambient ammonia and its effects on particulate ammonium in winter of urban Beijing, China - Rui Zhang; Yuhua Han; Aijun Shi; Xuesong Sun; Xiao Yan; Yuhu Huang; Yu Wang (Environmental Science and Pollution Research, 2021)

Exposure to 2,4-dichlorophenol, 2,4,6-trichlorophenol, pentachlorophenol and risk of thyroid cancer: a case-control study in China - Wan-Jun Yang; Hua-Bing Wu; Chi Zhang; Qi Zhong; Ming-Jun Hu; Jia-Liu He; Guo-Ao Li; Zhen-Yu Zhu; Jin-Liang Zhu; Huan-Huan Zhao; Han-Shuang Zhang; Fen Huang (Environmental Science and Pollution Research, 2021)

Estimating dynamic population served by wastewater treatment plants using location-based services data - Han Yu; Xue-Ting Shao; Si-Yu Liu; Wei Pei; Xiang-Peng Kong; Zhuang Wang; De-Gao Wang (Environmental Geochemistry and Health, 2021)

Maritimibacter alexandrii sp. nov., a New Member of Rhodobacteraceae Isolated from Marine Phycosphere - Xing Wang; Yun Ye; Fei-Fei Xu; Yu-Han Duan; Peng-Fei Xie; Qiao Yang; Xiao-Ling Zhang (Current Microbiology, 2021)

Construction of a rAAV-SaCas9 system expressing eGFP and its application to improve muscle mass - Shaoting Weng; Yitian Zhao; Changhong Yu; Xiaofan Wang; Xuehan Xiao; Liqiang Han; Kunpeng Zhang; Jiang Wang; Guoyu Yang (Biotechnology Letters, 2021)
An ideal rAAV gene editing system not only effectively edits genes at specific site, but also prevents the spread of the virus from occurring off-target or carcinogenic risks. This is important for gene editing research at specific site in vivo. We report a single rAAV containing SaCas9 and guide RNAs under the control of subtle EF1a and tRNA promoters. The capacity of rAAV was compressed, and the editing efficiency was similar to that of the classical Cas9 system in vitro and in vivo. And we inserted the sequence of the green fluorescent protein eGFP into rAAV. The number of cells infected with the rAAV and the region in which the rAAV spreads were known by the fluorescent expression of eGFP in cells. In addition, we demonstrated that myostatin gene in the thigh muscles of C57BL/10 mice was knocked out by the rAAV9-SaCas9 system to make muscle mass increased obviously. The protein eGFP into rAAV has significant implications for our indirect analysis of the editing efficiency of SaCas9 in the genome of the target tissue and reduces the harm caused by off-target editing and prevents other tissue mutations. The rAAV system has substantial potential in improving muscle mass and preventing muscle atrophy.

Diagnostic evaluation of qRT-PCR-based kit and dPCR-based kit for COVID-19 - Cherl-Joon Lee; Wonseok Shin; Seyoung Mun; Minjae Yu; Young-Bong Choi; Dong Hee Kim; Kyudong Han (Genes & Genomics, 2021)

High-throughput sequencing revealed the expression profile and potential key molecules of the circular RNAs involved in the process of hypoxic adaptation in Tibetan chickens - Zengrong Zhang; Mohan Qiu; Huarui Du; Qingyun Li; Wu Gan; Xia Xiong; Chunlin Yu; Han Peng; Bo Xia; Xiaoyan Song; Li Yang; Chenming Hu; et al. (Biologia, 2021)

Zircon U–Pb geochronology from a Paleoproterozoic mafic dyke in the Jiapigou terrane (North China Craton): inferences about formation and evolution of the early crust - Shu Wang; Jinggui Sun; Ridong Yu; Jilong Han; Yuming Liu; Xiaolei Chu; Xinwen Zhang (Arabian Journal of Geosciences, 2021)

Increased Cu(II) Adsorption Onto UV-Aged Polyethylene, Polypropylene, and Polyethylene Terephthalate Microplastic Particles in Seawater - Xiaoxin Han; Rolf D. Vogt; Jiaying Zhou; Boyang Zheng; Xue Yu; Jianfeng Feng; Xueqiang Lu (Frontiers in Marine Science, 2021)
Environmental effects of microplastic are rather due to their adsorption capacity of contaminants than themselves. Aging is a key factor influencing adsorption properties of environmental microplastics. In order to clarify this influence, polyethylene (PE), polypropylene (PP), and polyethylene terephthalate (PET) microplastics with particle sizes of <0.9 mm, 0.9–2 mm, and 2–5 mm were artificially aged in seawater for 12 months. This enabled an assessment of the change in Cu(II) adsorption capacity to the microplastics particles under aging. According to the FTIR spectra, fresh microplastics were oxidized during the UV induced aging process. The adsorption capacities of microplastic were positively correlated with their aging time. After 12-months aging, the amount of Cu(II) adsorbed to the aged microplastics was 1.45–2.92 times higher than on the fresh microplastic particles. For PP and PET, the aging effect increased with decreasing size of the microplastic particles. In the case of PE, particles with the medium particle size (0.9–2 mm) had the strongest aging effect.

Dynamic Regulation of Ions and Amino Acids in Adult Asian Hard Clams Meretrix lusoria Upon Hyperosmotic Salinity - Chia-Hao Lin; Po-Ling Yeh; Yu-Chun Wang; Tsung-Han Lee (Frontiers in Marine Science, 2021)
The dynamic regulation of ions and amino acids in the gills and mantle of the Asian hard clam, Meretrix lusoria , following the exposure to a hyperosmotic environment was hitherto unclear. The present study revealed that the osmolality as well as the Na + and Cl – concentrations in the hemolymph were significantly increased 3 h after transferring the clams from an environment with the salinity of their natural habitat (brackish water; BW; 20‰) to one with hyperosmotic salinity (seawater; 35‰). In addition, we found that the specific activities of Na + /K + -ATPase, a key enzyme that plays a significant role in cell osmoregulation, in the gills and mantle of clams were significantly increased at 72 and 12 h post-transfer, respectively, during acclimation to hyperosmotic salinity. Similarly, the contents of free amino acids (FAAs) such as taurine, alanine, and glycine were significantly elevated during hyperosmotic salinity acclimation. Previous research indicates that taurine is the most abundant FAA in the gills and mantles of Asian hard clams and that the taurine transporter (TAUT) plays an important role in taurine accumulation. The present study showed that TAUT mRNA and protein expression were significantly and transiently increased in the mantle of Asian hard clams following exposure to seawater; although the expression of TAUT mRNA in the gills of Asian hard clams was also transiently stimulated by exposure to hyperosmotic salinity, the relative TAUT protein abundance decreased only at later stages. Accordingly, the findings of this study improve our understanding of the dynamic processes of ion and amino acid regulation in the peripheral tissues of bivalves under hyperosmotic stress.

Impacts of pH on the Fitness and Immune System of Pacific White Shrimp - Veran Weerathunga; Wei-Jen Huang; Sam Dupont; Hsueh-Han Hsieh; Nathangi Piyawardhana; Fei-Ling Yuan; Jhe-Syuan Liao; Chia-Yu Lai; Wei-Ming Chen; Chin-Chang Hung (Frontiers in Marine Science, 2021)
The atmospheric partial pressure of CO 2 ( p CO 2 ) has been increasing dramatically since the beginning of the industrial revolution and about 30% of the CO 2 produced by anthropogenic activities was absorbed by the ocean. This led to a perturbation of the seawater carbonate chemistry resulting in a decrease of the average surface ocean pH by 0.1 and termed ocean acidification (OA). Projections suggest that p CO 2 may reach 900 μatm by the end of the twenty-first century lowering the average pH of the surface ocean by 0.4 units. The negative impacts of OA on many species of marine invertebrates such as mollusks, echinoderms, and crustaceans are well documented. However, less attention has been paid to the impacts of low pH on fitness and immune system in crustaceans. Here, we exposed Pacific white shrimps to 3 different pHs (nominal pH 8.0, 7.9, and 7.6) over a 100-days experiment. We found that, even though there were no significant effects on fitness parameters (survival, growth and allometries between length and weight), some immune markers were modified under low pH. A significant decrease in total hemocyte count and phenoloxidase activity was observed in shrimps exposed to pH 7.6 as compared to pH 8.0; and phagocytosis rate significantly decreased with decreasing pH. A significant increase in superoxide production was also observed at pH 7.6 as compared to pH 8.0. All these results suggest that a 100-days exposure to pH 7.6 did not have a direct effect on fitness but lead to a modulation of the immune response.

Social disruption–induced stress pre-exposure aggravates, while the presence of conspecifics diminishes, acetic acid–induced writhing - Yi-Han Liao; Yi-Chi Su; Yu-Han Huang; Hao Chen; Ya-Hsuan Chan; Li-Han Sun; Chianfang G. Cherng; Ing-Tiau B. Kuo; Lung Yu (Psychopharmacology, 2021)

GmFULa improves soybean yield by enhancing carbon assimilation without altering flowering time or maturity - Yanlei Yue; Shi Sun; Jiawen Li; Haidong Yu; Hongxia Wu; Baiquan Sun; Tao Li; Tianfu Han; Bingjun Jiang (Plant Cell Reports, 2021)
Key message GmFULa improved soybean yield by enhancing carbon assimilation. Meanwhile, different from known yield-related genes, it did not alter flowering time or maturity. Abstract Soybean ( Glycine max (L.) Merr.) is highly demanded by a continuously growing human population. However, increasing soybean yield is a major challenge. FRUITFULL ( FUL ), a MADS-box transcription factor, plays important roles in multiple developmental processes, especially fruit and pod development, which are crucial for soybean yield formation. However, the functions of its homologs in soybean are not clear. Here, through haplotype analysis, we found that one haplotype of the soybean homolog GmFULa ( GmFULa-H02 ) is dominant in cultivated soybeans, suggesting that GmFULa-H02 was highly selected during domestication and varietal improvement of soybean. Interestingly, transgenic overexpression of GmFULa enhanced vegetative growth with more biomass accumulated and ultimately increased the yield but without affecting the plant height or changing the flowering time and maturity, indicating that it enhances the efficiency of dry matter accumulation. It also promoted the yield factors like branch number, pod number and 100-seed weight, which ultimately increased the yield. It increased the palisade tissue cell number and the chlorophyll content to promote photosynthesis and increase the soluble sugar content in leaves and fresh seeds. Furthermore, GmFULa were found to be sublocalized in the nucleus and positively regulate sucrose synthases ( SUSs ) and sucrose transporters ( SUTs ) by binding with the conserved CArG boxes in their promoters. Overall, these results showed GmFULa promotes the capacity of assimilation and the transport of the resultant assimilates to increase yield, and provided insights into the link between GmFULa and sucrose synthesis with transport-related molecular pathways that control seed yield.

Complement C3 Aggravates Post-epileptic Neuronal Injury Via Activation of TRPV1 - Guang-Tong Jiang; Lin Shao; Shuo Kong; Meng-Liu Zeng; Jing-Jing Cheng; Tao-Xiang Chen; Song Han; Jun Yin; Wan-Hong Liu; Xiao-Hua He; Yu-Min Liu; Lanzi Gongga; et al. (Neuroscience Bulletin, 2021)

Chronic Exposure to Hypoxia Inhibits Myelinogenesis and Causes Motor Coordination Deficits in Adult Mice - Lin Chen; Shu-Yu Ren; Rui-Xue Li; Kun Liu; Jing-Fei Chen; Yu-Jian Yang; Yong-Bin Deng; Han-Zhi Wang; Lan Xiao; Feng Mei; Fei Wang (Neuroscience Bulletin, 2021)
Exposure to chronic hypoxia is considered to be a risk factor for deficits in brain function in adults, but the underlying mechanisms remain largely unknown. Since active myelinogenesis persists in the adult central nervous system, here we aimed to investigate the impact of chronic hypoxia on myelination and the related functional consequences in adult mice. Using a transgenic approach to label newly-generated myelin sheaths ( NG2-CreER TM ; Tau-mGFP ), we found that myelinogenesis was highly active in most brain regions, such as the motor cortex and corpus callosum. After exposure to hypoxia (10% oxygen) 12 h per day for 4 weeks, myelinogenesis was largely inhibited in the 4-month old brain and the mice displayed motor coordination deficits revealed by the beam-walking test. To determine the relationship between the inhibited myelination and functional impairment, we induced oligodendroglia-specific deletion of the transcription factor Olig2 by tamoxifen ( NG2-CreER TM ; Tau-mGFP; Olig2 fl/fl ) in adult mice to mimic the decreased myelinogenesis caused by hypoxia. The deletion of Olig2 inhibited myelinogenesis and consequently impaired motor coordination, suggesting that myelinogenesis is required for motor function in adult mice. To understand whether enhancing myelination could protect brain functions against hypoxia, we treated hypoxic mice with the myelination-enhancing drug-clemastine, which resulted in enhanced myelogenesis and improved motor coordination. Taken together, our data indicate that chronic hypoxia inhibits myelinogenesis and causes functional deficits in the brain and that enhancing myelinogenesis protects brain functions against hypoxia-related deficits.

Subcutaneous toxicity of melittin-dKLA in ICR mice - Jiham Sung; Yura Kim; Pei Fu Yu; Younsub Kim; Ik-Hwan Han; Hyunsu Bae (Molecular & Cellular Toxicology, 2021)

Therapeutic Potential of Cytokines in Demyelinating Lesions After Stroke - Yi-Sha Guo; Mei Yuan; Yu Han; Xin-Ya Shen; Zhen-Kun Gao; Xia Bi (Journal of Molecular Neuroscience, 2021)

Removal efficacy of opportunistic pathogen gene markers in drinking water supply systems: an in situ and large-scale molecular investigation - Ziming Han; Junying Lu; Wei An; Yu Zhang; Min Yang (Environmental Science and Pollution Research, 2021)

Growth inhibition and oxidative damage of Microcystis aeruginosa induced by aqueous extract of different submerged macrophytes - Jinlong Han; Yue Yin; Duo Xu; Hao Wang; Shuang Yu; Dongyun Han; Yunxia Niu; Runyu Xu (Environmental Science and Pollution Research, 2021)

Collinsella acetigenes sp. nov., an Anaerobic Actinobacterium Isolated from Human Feces, and Emended Description of the Genus Collinsella and Collinsella aerofaciens - Kook-Il Han; Ji-Sun Kim; Mi Kyung Eom; Keun Chul Lee; Min Kuk Suh; Han Sol Kim; Seung-Hwan Park; Ju Huck Lee; Se Won Kang; Jam-Eon Park; Byeong Seob Oh; Seoung Woo Ryu; et al. (Current Microbiology, 2021)

Sources, Toxicity and Detection Techniques of Semicarbazide: A Review - Xiuhui Tian; Huanjun Li; Dianfeng Han; Fenggong Wen; Huan Liu; Ge Liu; Kaixiu Peng; Xianghong Gong; Xin Liu; Weiyun Wang; Haixia Yu; Yingjiang Xu (Journal of Ocean University of China, 2021)

Raspberry (Rubus idaeus L.) NCED1 gene enhances high salinity and cold tolerance in Arabidopsis - Guohui Yang; Yuxiao Chen; Heng Yu; Hang Zhang; Deguo Han; Xiaoyu Guo; Enqing Yan; Hanyi Quan; Tiemei Li (In Vitro Cellular & Developmental Biology - Plant, 2021)

Highly sialylated mucin-type glycopeptide from porcine intestinal mucosa after heparin extraction: O-glycan profiling and immunological activity evaluation - Xin Zhang; Chen Wang; Qing Han; Xuan Chen; Guoyun Li; Guangli Yu (Glycoconjugate Journal, 2021)

Stenotrophomonas strain CPCC 101271, an intestinal lifespan-prolonging bacterium for Caenorhabditis elegans that assists in host resistance to “Bacillus nematocida” colonization - Rui Han; Yu Wang; Yang Deng; Yuqin Zhang; Lin Zhang; Qiuhong Niu (Archives of Microbiology, 2021)
The soil-dwelling, opportunistic pathogenic bacterium "Bacillus nematocida" B16 exhibits strong killing activities against a variety of pathogenic nematodes via a “Trojan horse” mechanism that can kill worm species like Caenorhabditis elegans . The bacterial strain CPCC 101271 was previously isolated from the intestines of C. elegans that were recovered from natural habitats and can serve as a probiotic for C. elegans , while also assisting in resistance to infection by the pathogenic strain B16. In this study, the lifespan of C. elegans fed with strain CPCC 101271 cells was extended by approximately 40% compared with that of worms fed with Escherichia coli OP50 cells. In addition, the colonization of C. elegans by the pathogenic bacterium "B. nematocida" B16 was inhibited when pre-fed with strain CPCC 101271. Metagenomic sequence analysis of intestinal microbiota of C. elegans fed with strain CPCC 101271 and infected with B16 revealed that pre-feeding worms with CPCC 101271 improved the diversity of the intestinal bacteria. Moreover, community structure significantly varied in coordination with Stenotrophomonas spp. and Bacillus spp. abundances when competition between strains CPCC 101271 and B16 was evaluated. In conclusion, the nematode microbiota strain CPCC 101271 assisted in its host resistance to colonization by the pathogen "Bacillus nematocida" and can also promote life span-prolongation in C. elegans. These results underscore that understanding the interactions between C. elegans microbiota and pathogens can provide new insights into achieving effective biological control of agricultural pests.

The influence of Stokes drift on oil spills: Sanchi oil spill case - Yiqiu Yang; Yan Li; Juan Li; Jingui Liu; Zhiyi Gao; Kaixuan Guo; Han Yu (Acta Oceanologica Sinica, 2021)

Plant traits and soil fertility mediate productivity losses under extreme drought in C 3 grasslands - Wentao Luo; Robert J. Griffin‐Nolan; Wang Ma; Bo Liu; Xiaoan Zuo; Chong Xu; Qiang Yu; Yahuang Luo; Pierre Mariotte; Melinda D. Smith; Scott L. Collins; Alan K. Knapp; et al. (Ecology, 2021)
Extreme drought decreases aboveground net primary production (ANPP) in most grasslands, but the magnitude of ANPP reductions varies especially in C 3 ‐dominated grasslands. Because the mechanisms underlying such differential ecosystem responses to drought are not well resolved, we experimentally imposed an extreme 4‐yr drought (2015–2018) in two C 3 grasslands that differed in aridity. These sites had similar annual precipitation and dominant grass species ( Leymus chinensis ) but different annual temperatures and thus water availability. Drought treatments differentially affected these two semiarid grasslands, with ANPP of the drier site reduced more than at the wetter site. Structural equation modeling revealed that community‐weighted means for some traits modified relationships between soil moisture and ANPP, often due to intraspecific variation. Specifically, drought reduced community mean plant height at both sites, resulting in a reduction in ANPP beyond that attributable to reduced soil moisture alone. Higher community mean leaf carbon content enhanced the negative effects of drought on ANPP at the drier site, and ANPP–soil‐moisture relationships were influenced by soil C:N ratio at the wetter site. Importantly, neither species richness nor functional dispersion were significantly correlated with ANPP at either site. Overall, as expected, soil moisture was a dominant, direct driver of ANPP response to drought, but differential sensitivity to drought in these two grasslands was also related to soil fertility and plant traits.

Incorporating Species-Conditional Co-Occurrence When Selecting Indicator Species to Monitor Restoration after Mangrove Removal from the Siangshan Wetland, Taiwan - Ta-Jen Chu; Chun-Han Shih; Yu-Ming Lu; Yi-Jia Shih; Jia-Qiao Wang; Liang-Ming Huang (Journal of Marine Science and Engineering, 2021)
This paper presents an approach for incorporating species-conditional co-occurrence into models used for the selection of marine indicator species. Mangrove invasion within the Siangshan Wetland in Hsinchu, Taiwan, has changed the original structures and functions of habitats for benthic organisms. The Hsinchu City Government ran a large-scale mangrove removal project from October 2015 to March 2016 to restore the wetland. From October 2015 to September 2016, we investigated the biological effects of mangrove removal on benthic crabs and their adjacent habitats. Density, number of species, Shannon–Weaver index (H′) and Palou’s evenness index (J′) were calculated and compared between mangrove and non-mangrove regions. The results showed that values for these attributes in the non-mangrove regions were higher than those of the mangrove regions. After mangrove removal, species returned to their original habitats and the related density increased significantly. Using conditional co-occurrence algorithms, we identified five indicator species (Mictyris brevidactylus, Macrophthalmus banzai, Uca arcuata, Uca lacteal and Uca borealis) with high co-occurrence probabilities, whose population responses provided direct evidence of the benefits of mangrove removal for wetland restoration. The results indicate that mangrove removal is an appropriate habitat rehabilitation strategy for benthic organisms, and that the chosen indicator species may provide valuable ecological information for coastal managers seeking to control the spread of mangroves.

Association between large artery stenosis, cerebral small vessel disease and risk of ischemic stroke - Fei Han; Ding-Ding Zhang; Fei-Fei Zhai; Jun Xue; Jiang-Tao Zhang; Shuang Yan; Li-Xin Zhou; Jun Ni; Ming Yao; Meng Yang; Ming-Li Li; Zheng-Yu Jin; et al. (Science China Life Sciences, 2021)

Size Effect and Anisotropy in a Transversely Isotropic Rock Under Compressive Conditions - Kaihui Li; Zhen-Yu Yin; Dongya Han; Xiang Fan; Rihong Cao; Hang Lin (Rock Mechanics and Rock Engineering, 2021)

Descending Modulation of Spinal Itch Transmission by Primary Somatosensory Cortex - Zi-Han Wu; Han-Yu Shao; Yuan-Yuan Fu; Xiao-Bo Wu; De-Li Cao; Sheng-Xiang Yan; Wei-Lin Sha; Yong-Jing Gao; Zhi-Jun Zhang (Neuroscience Bulletin, 2021)

Integration of small RNAs, degradome, and transcriptome sequencing provides insights into the differences between Shizhu ginseng and Yuan ginseng - Mengyuan Peng; Yanlin Chen; Wenjuan Wang; Zhihua He; Wangqiang Dai; Zhiyun Lin; Zemin Yang; Mengjuan Gong; Yongqin Yin; Bin Han; Yu Zeng; Yingfang Wang (Journal of Plant Biochemistry and Biotechnology, 2021)
Panax ginseng is one of the most popular herbs which have been used as an important traditional Chinese medicine since ancient times. Yuan ginseng and Shizhu ginseng,which belong to P. ginseng , are widely used as substitutes for wild ginseng in clinical practice. Clinical practice has proved that the clinical efficacy of Shizhu ginseng is better than Yuan ginseng. However, current research cannot completely explain this phenomenon. Considering that small RNA may be one of the pharmacodynamic substances of P. ginseng , it is challenging to investigate differential miRNAs between Shizhu ginseng and Yuan ginseng. In this study, the transcriptome, small RNAome and degradome of P. ginseng were studied by high-throughput sequencing. A total of 63,875 unigenes and 43,950,137 small RNA clean reads were obtained from the roots of P. ginseng . Among 3206 differentially expressed genes, 1190 genes were up-regulated in Yuan ginseng when compared with Shizhu ginseng. 24 known differential miRNAs and 7 novel differential miRNAs were obtained. The 304 targets of 24 differentially expressed miRNA (17 known and 7 novel) families are mainly related to energy metabolism, biotic stress and disease immunity in ginseng itself. Through the association analysis of mRNA and miRNA, our work gives a better understanding of the difference between Yuan ginseng and Shizhu ginseng. Considering the cross-kingdom regulation of plant miRNAs, our results may provide a foundation for understanding the miRNA-dependent clinical efficacy in P. ginseng .

Provenance and tectonic implications of early Paleozoic sedimentary rocks in the Central Altyn Tagh terrane, southeast of the Tarim craton - Qian Liu; Toshiaki Tsunogae; Guochun Zhao; Yigui Han; Zengchan Dong; Ningchao Zhou; Jinlong Yao; Peng Wang; Yu Wu (International Journal of Earth Sciences, 2021)

The Preventive Effects of Lactobacillus casei on Acute Lung Injury Induced by Lipopolysaccharide - Lihui Zhao; Ying Mao; Haiming Yu; He Liu; Chao Wang; Jianwei Liu; Yutong Han; Yang Bi; Donghai Zhang (Indian Journal of Microbiology, 2021)

Adverse effects of short-term personal exposure to fine particulate matter on the lung function of patients with chronic obstructive pulmonary disease and asthma: a longitudinal panel study in Beijing, China - Ruirui Duan; Hongtao Niu; Tao Yu; Ke Huang; Han Cui; Chen Chen; Ting Yang; Chen Wang (Environmental Science and Pollution Research, 2021)

Apigenin Improves Hypertension and Cardiac Hypertrophy Through Modulating NADPH Oxidase-Dependent ROS Generation and Cytokines in Hypothalamic Paraventricular Nucleus - Hong-Li Gao; Xiao-Jing Yu; Han-Bo Hu; Qian-Wen Yang; Kai-Li Liu; Yan-Mei Chen; Yan Zhang; Dong-Dong Zhang; Hua Tian; Guo-Qing Zhu; Jie Qi; Yu-Ming Kang (Cardiovascular Toxicology, 2021)

Human Methylmercury Exposure and Potential Impacts in Central Tibet: Food and Traditional Tibetan Medicine - Menghan Cheng; Maodian Liu; Dou Li; Qing Luo; Zhihao Zhang; Liuliang Yuan; Chenghao Yu; Han Xie; Huiming Lin; Qianru Zhang; De Ji; Xuejun Wang (Bulletin of Environmental Contamination and Toxicology, 2021)

Evaluation of freeze–thaw erosion in Tibet based on the cloud model - Junfu Fan; Taoying Hu; Xiao Yu; Jiahao Chen; Liusheng Han; Yuke Zhou (Frontiers of Earth Science, 2021)

Fine mapping and candidate gene analysis of a major locus controlling ovule abortion and seed number per silique in Brassica napus L. - Yangmiao Jiao; Kunpeng Zhang; Guangqin Cai; Kaidi Yu; Olalekan Amoo; Shaoqing Han; Xiang Zhao; Hao Zhang; Limin Hu; Bingrui Wang; Chuchuan Fan; Yongming Zhou (Theoretical and Applied Genetics, 2021)

Disaster preparedness, perceived community resilience, and place of rural villages in northwest China - Timothy Sim; Ziqiang Han; Chunlan Guo; Jocelyn Lau; Junlei Yu; Guiwu Su (Natural Hazards, 2021)

Ferroptosis is involved in the development of neuropathic pain and allodynia - Huixing Wang; Xiaodong Huo; Chenyang Han; Jiang Ning; Hongguang Chen; Bo Li; Jingzhi Liu; Wenting Ma; Quanbo Li; Yonghao Yu; Kemei Shi (Molecular and Cellular Biochemistry, 2021)

The protective effect of hydrogen-rich water on rats with type 2 diabetes mellitus - Mengna Zheng; Han Yu; Yong Xue; Tong Yang; Qiufen Tu; Kaiqing Xiong; Daihua Deng; Lei Lu; Nan Huang (Molecular and Cellular Biochemistry, 2021)

Omega-3 fatty acid protects cardiomyocytes against hypoxia-induced injury through targeting MiR-210-3p/CASP8AP2 axis - Xueju Yu; Fengyao Liu; Yuting Liu; Bingqing Bai; Han Yin; Haochen Wang; Yingqing Feng; Huan Ma; Qingshan Geng (Molecular and Cellular Biochemistry, 2021)

Screening and application of SSR markers related to seed storability traits in maize (Zea mays L.) - Xiaoyang Guo; Xiaohui Sun; Shan Liu; Chengxu Gong; Chenchen Feng; Xiao Han; Tingting Lv; Yu Zhou; Zhenhua Wang; Hong Di (Genetic Resources and Crop Evolution, 2021)

Long Non-coding RNA Expression Profile in Broiler Liver with Cadmium-Induced Oxidative Damage - Chunlin Yu; Chaowu Yang; Xiaoyan Song; Jingjing Li; Han Peng; Mohan Qiu; Li Yang; Huarui Du; Xiaosong Jiang; Yiping Liu (Biological Trace Element Research, 2021)

Variations in aeolian landform patterns in the Gonghe Basin over the last 30 years - Yu-han Qi; Mei-hui Pan; Ze-wen Hao; An-na Yang; Wen-xuan Xue (Journal of Mountain Science, 2021)

Sum of High-Risk Gene Mutation (SHGM): A Novel Attempt to Assist Differential Diagnosis for Adrenocortical Carcinoma with Benign Adenoma, Based on Detection of Mutations of Nine Target Genes - Guo-Yang Zheng; Xue-Bin Zhang; Han-Zhong Li; Yu-Shi Zhang; Jian-Hua Deng; Xing-Cheng Wu (Biochemical Genetics, 2021)
There has been no research on applying gene detection to differential diagnosis of adrenocortical carcinoma (ACC). We attempted to explore a novel auxiliary method for differential diagnosis between ACC with benign adrenocortical adenoma (ACA), based on mutations of target genes in tissues. Nine genes were chosen as target genes, including TP53, CTNNB1, ARMC5, PRKAR1A, ZNRF3, RB1, APC, MEN1, and RPL22 . Exons sequencing of target genes were performed in 98 cases of tissue samples by FastTarget technology, including 41 ACC tissues, 32 ACA tissues, and 25 normal adrenal gland tissues. Significant mutations were detected and identified, and the clinical information was collected, for further comparative analysis and application to assist differential diagnosis of ACC. We identified 132 significant gene mutations and 227 significant mutation sites in 37 ACC tissues, much more than ACA and normal adrenal gland tissues. Mutation rates of 6 genes in ACC tissues were obviously higher than ACA tissues, including ZNRF3, ARMC5, TP53, APC, RB1, and PRKAR1A , regarded as high-risk genes. The sum of mutated high-risk genes detected in each sample was denominated sum of high-risk gene mutation (SHGM), and the rates of SHGM > 0 and SHGM > 1 in ACC tissues were 73.0% and 62.2%, respectively, both obviously higher than those in ACA tissues, with significant statistic differences. Especially for 8 cases of ACC with diameter 0 and SHGM > 1 were found in 6 samples (75%) and 4 samples (50%), respectively. However, no relevance was found between SHGM and clinical characteristics of ACC. We identified 6 high-risk genes in ACC tissues, with significantly higher mutation rates than ACA or normal adrenal gland tissues. The sum of mutated high-risk genes detected in ACC tissues was denominated SHGM, which was potential to assist the differential diagnosis of ACC with ACA, especially for the small-size ACC.

Porcine circovirus type 2 (PCV2) infection in Hebei Province from 2016 to 2019: a retrospective study - Lei Han; Guang-fu Yuan; Shao-jie Chen; Fei Dai; Lin-shan Hou; Jing-hui Fan; Yu-zhu Zuo (Archives of Virology, 2021)

Complete genome sequence of the Pseudomonas oleovorans strain ODT-83 isolated from oyster - Mingshu Yang; Feng Han; Yongxin Yu; Yongjie Wang (Archives of Microbiology, 2021)

Aquiflexum lacus sp. nov., isolated from a lake sediment sample - Jianrong Huang; Mingxian Han; Baozhu Fang; Jian Yang; Haiyi Xiao; Xiying Zhang; Jibin Han; Dongmei Yu; Hongchen Jiang; Wenjun Li (Archives of Microbiology, 2021)

Lipid biomarker composition in surface sediments from the Carlsberg Ridge near the Tianxiu Hydrothermal Field - Shengyi Mao; Hongxiang Guan; Lihua Liu; Xiqiu Han; Xueping Chen; Juan Yu; Yongge Sun; Yejian Wang (Acta Oceanologica Sinica, 2021)

Antimicrobial Defensin and DNA Traps in Manila Clam Ruditapes philippinarum: Implications for Their Roles in Immune Responses - Yijing Han; Gege Hu; Yuying Chen; Lizhu Chen; Daode Yu; Qianqian Zhang; Dinglong Yang (Frontiers in Marine Science, 2021)
Although defensins have been isolated from a variety of metazoan, their role in cellular immunity has not been answered. In the study, we found that the hemocytes of the Manila clams Ruditapes philippinarum release defensin (designated as Rpdef3) in response to Vibrio parahaemolyticus challenge. The antimicrobial Rpdef3 was proved to be involved in the extracellular traps (ETs) that hemocytes released in response to Vibrio challenge. Scanning electron microscopy observation proved the patterns how ETs eliminate invading bacteria. Furthermore, Rpdef3 involved in ETs had broad-spectrum antimicrobial effect on both Gram-negative bacteria and Gram-positive bacteria. ELISA assay revealed that Rpdef3 could bind lipopolysaccharides and peptidoglycan in a dose-dependent manner. As concerned to the antibacterial mechanisms, Rpdef3 can cause bacterial membrane permeabilization, leading to cell death. As a result, Rpdef3 might contribute to the trap and the elimination of invading Vibrio in clam ETs. Taken together, our study suggest that the formation of ETs is a defense mechanism triggered by bacterial stimulation, coupled with antibacterial defensin.

NestNet: a multiscale convolutional neural network for remote sensing image change detection - Xiao Yu; Junfu Fan; Jiahao Chen; Peng Zhang; Yuke Zhou; Liusheng Han (International Journal of Remote Sensing, 2021)

Refined mapping of stripe rust resistance gene YrP10090 within a desirable haplotype for wheat improvement on chromosome 6A - Shengjie Liu; Shuo Huang; Qingdong Zeng; Xiaoting Wang; Rui Yu; Qilin Wang; Ravi P. Singh; Sridhar Bhavani; Zhensheng Kang; Jianhui Wu; Dejun Han (Theoretical and Applied Genetics, 2021)

Changes in water‐soluble nitrogen and organic carbon in the post‐fire litter layer of Dahurian larch forests - Yuetai Weng; Guang Yang; Lixuan Wang; Xiankui Quan; Xueying Di; Hongzhou Yu; Dongdong Han (Plant and Soil, 2021)

A new method for weakening slaking of collecting eroded aggregates by water erosion - Yu Fu; Yikai Zhao; Han Wang; Xiangwei Chen; Yuxi Wang (Journal of Soils and Sediments, 2021)

Microwave hydrothermal fabrication of 3D hierarchical Br/Bi2WO6 with enhanced photocatalytic activity for Rhodamine B and tetracycline degradation - Rongrong Song; Ninghua Chen; Biao Han; Sishan Yu; Yue Wang; Kun Liu; Zhangfa Tong; Hanbing Zhang (Environmental Science and Pollution Research, 2021)

Biological characteristics and salt-tolerant plant growth-promoting effects of an ACC deaminase-producing Burkholderia pyrrocinia strain isolated from the tea rhizosphere - Lizhen Han; Hong Zhang; Yu Xu; Ying Li; Jing Zhou (Archives of Microbiology, 2021)

Preparation and Characterization of a Lutein Solid Dispersion to Improve Its Solubility and Stability - Chaemin Lim; Jin Kook Kang; Chan Eun Jung; Taehoon Sim; Jaewon Her; Kioh Kang; Eun Seong Lee; Yu Seok Youn; Han-Gon Choi; Kyung Taek Oh (AAPS PharmSciTech, 2021)

Topography-dependent climatic sensitivities in spruce tree growth in the Changbai Mountain, Northeast China - Shoule Wang; Xiaoyu Wang; Xuerui Gai; Li Zhou; Wangming Zhou; Yangang Han; Dapao Yu (Trees, 2021)

Genetic Architecture of Childhood Kidney and Urological Diseases in China - Ye Fang; Hua Shi; Tianchao Xiang; Jiaojiao Liu; Jialu Liu; Xiaoshan Tang; Xiaoyan Fang; Jing Chen; Yihui Zhai; Qian Shen; Guomin Li; Li Sun; et al. (Phenomics, 2021)
Kidney disease is manifested in a wide variety of phenotypes, many of which have an important hereditary component. To delineate the genotypic and phenotypic spectrum of pediatric nephropathy, a multicenter registration system is being implemented based on the Chinese Children Genetic Kidney Disease Database (CCGKDD). In this study, all the patients with kidney and urological diseases were recruited from 2014 to 2020. Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features. The genetic diagnosis was confirmed in 883 of 2256 (39.1%) patients from 23 provinces in China. Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome (SRNS, 23.5%), glomerulonephritis (GN, 32.2%), congenital anomalies of the kidney and urinary tract (CAKUT, 21.2%), cystic renal disease (3.9%), renal calcinosis/stone (3.6%), tubulopathy (9.7%), and chronic kidney disease of unknown etiology (CKDu, 5.8%). The pathogenic variants of 105 monogenetic disorders were identified. Ten distinct genomic disorders were identified as pathogenic copy number variants (CNVs) in 11 patients. The diagnostic yield differed by subgroups, and was highest in those with cystic renal disease (66.3%), followed by tubulopathy (58.4%), GN (57.7%), CKDu (43.5%), SRNS (29.2%), renal calcinosis /stone (29.3%) and CAKUT (8.6%). Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions. We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed. Our data demonstrate the utility of family-based exome sequencing, and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease.

Integrated Analysis of Coding Genes and Non-coding RNAs Associated with Shell Color in the Pacific Oyster (Crassostrea gigas) - Zhuanzhuan Li; Qi Li; Shikai Liu; Ziqiang Han; Lingfeng Kong; Hong Yu (Marine Biotechnology, 2021)

The Educational Program for Healthcare Providers Regarding Fertility Preservation for Cancer Patients: a Systematic Review - Han-feng Zhang; Qing-hua Jiang; Gui-yu Huang; Jun Kako; Kohei Kajiwara; Jian-xia Lyu; Mika Miyashita (Journal of Cancer Education, 2021)

The Knowledge and Attitude Towards Advance Care Planning Among Chinese Patients with Advanced Cancer - Xiao-Ting Hou; Yu-Han Lu; Hong Yang; Ren-Xiu Guo; Yun Wang; Li-Hong Wen; Ya-Ru Zhang; Hong-Yu Sun (Journal of Cancer Education, 2021)

Occurrence, distribution, and partitioning of antibiotics in surface water and sediment in a typical tributary of Yellow River, China - Linfang Wang; Hua Li; Jinhua Dang; Hong Guo; Yu’en Zhu; Wenhui Han (Environmental Science and Pollution Research, 2021)

Paleoclimatic proxies from global closed basins and the possible beginning of Anthropocene - Yu Li; Qin Han; Lu Hao; Xinzhong Zhang; Dawei Chen; Yuxin Zhang; Lingmei Xu; Wangting Ye; Simin Peng; Yichan Li; Zhuowen Feng; Hebin Liu (Journal of Geographical Sciences, 2021)

RETRACTED ARTICLE: Soil erosion and regional industrial upgrading in the Yangtze River surrounding area based on ecological evaluation - Yu Jiajia; Han Yuqi; Gao Qian (Arabian Journal of Geosciences, 2021)

Germination dynamics of allergenic fungal spores in respiratory mucus - Wan-Rou Lin; Szu-Yu Chen; Shih-Ching Hsiao; Pi-Han Wang (Aerobiologia, 2021)

Simple estimation of green area rate using image analysis and quantitative traits related to plant architecture and biomass in rice seedling - Kwang-O. Jong; Kwang-Myong Han; Son-Il Kwak; Yu-Jin Jang; Chol-Ho; Kwang -Phil Kim (Theoretical and Experimental Plant Physiology, 2021)

A cloud classification method based on random forest for FY-4A - Zhuofu Yu; Shuo Ma; Ding Han; Guanlin Li; Ding Gao; Wei Yan (International Journal of Remote Sensing, 2021)

Difference Analysis on Sandstone Permeability After Treatment at Different Temperatures During the Failure Process: A Case Study of Sandstone in Chongqing, China - Weijing Xiao; Dongming Zhang; Haitao Li; Guo Yu; Han Yang; Beichen Yu (Pure and Applied Geophysics, 2021)

Disulfiram inhibits inflammation and fibrosis in a rat unilateral ureteral obstruction model by inhibiting gasdermin D cleavage and pyroptosis - Yu Zhang; Ruicheng Zhang; Xiaohu Han (Inflammation Research, 2021)

Prediction of oral hepatotoxic dose of natural products derived from traditional Chinese medicines based on SVM classifier and PBPK modeling - Size Li; Yiqun Yu; Xiaolan Bian; Li Yao; Min Li; Yan-Ru Lou; Jing Yuan; Hai-shu Lin; Lucy Liu; Bing Han; Xiaoqiang Xiang (Archives of Toxicology, 2021)

Herbidospora solisilvae sp. nov., a novel cellulose-degrading actinobacterium isolated from forest soil - Mingying Yu; Rui Zhou; Jingjing Li; Liyuan Han; Han Wang; Siyu Zhang; Junwei Zhao; Xiangjing Wang; Jia Song; Wensheng Xiang (Antonie van Leeuwenhoek, 2021)

Innovation Concept Model and Prototype Validation of Robotic Fish with a Spatial Oscillating Rigid Caudal Fin - Shuyan Wang; Yu Han; Shiteng Mao (Journal of Marine Science and Engineering, 2021)
Inspired by carangiform fish with a high-aspect ratio of the caudal fin’s up-down swing, but also by dolphins with a similar caudal fin’s left-right swing, a robotic fish with a spatial oscillating rigid caudal fin is implemented to optimize propulsion and maneuverability, whose orientation could be transformed to any position of a taper domain. First, three steering-engines were adopted to make the conceptual prototype, and an experimental apparatus for measuring thrust, lift forces, lateral forces and torque was developed. Then, three comparison experiments, respectively corresponding to the three modes of cruise, diving and maneuvering in random space, were conducted to imitate bionic fish’s hydrodynamics. The comparison results of the experiments proved that propelling and maneuvering in any direction could be realized through changing the orientation of the spatial oscillating rigid caudal fin.

Influence of Non-protein Diets on Hepatic Metabolism and Endocrine in Barramundi (Lates calcarifer) - Zhengyi Fu; Shengjie Zhou; Gang Yu; Rui Yang; Mingyang Han; Zhenhua Ma (Frontiers in Marine Science, 2021)
This study evaluated the effects of different dietary non-protein energy sources on hepatic metabolism and endocrine of barramundi. Fish were fed iso-energy diets (18 MJ kg –1 ) with two types of non-protein energy source in the experimental group and a regular diet was used as the control. The feeding trial lasted 56 days. In the present study, CPT1 and SCD expression in fish fed high lipid diet were upregulated and liver lipid metabolism was more active than the control group. Serum biochemical parameters including serum glucose, serum triacylglycerol and serum cholesterol were significantly increased. The IGF-I and IGF-II expressions were significantly upregulated, and growth performances were improved in fish fed the high lipid diet. When barramundi were fed with the high carbohydrate diet, GK expression was downregulated and cPEPCK expression was upregulated, indicating that glycogen might accumulate in liver. The fluctuation of serum biochemical parameters and the growth performance were not significantly different compared to the control group. In conclusion, high lipid diet can shorten the raising period, but it causes the change of metabolic level and the increase of useless adipose tissue; The high carbohydrate diet did not significantly improve the growth performance, and no significant metabolic abnormalities were observed, indicating that carbohydrate has the potential to be the feed energy supply source for juvenile barramundi. The results provide insights for further understanding the availability of non-protein energy sources in the diet of juvenile barramundi.

Correction to: A Novel Method to Differentiate Tonsil-Derived Mesenchymal Stem Cells In Vitro into Estrogen-Secreting Cells - Hee-Yeon Kim; Younghay Lee; Hee-Soo Yoon; Yu-Hee Kim; Kyung-Ah Cho; So-Youn Woo; Han Su Kim; Bo Young Park; Sung-Chul Jung; Inho Jo; Woo-Jae Park; Joo-Won Park; et al. (Tissue Engineering and Regenerative Medicine, 2021)

A Novel Method to Differentiate Tonsil-Derived Mesenchymal Stem Cells In Vitro into Estrogen-Secreting Cells - Hee-Yeon Kim; Younghay Lee; Hee-Soo Yoon; Yu-Hee Kim; Kyong-A Cho; So-Youn Woo; Han Sun Kim; Bo-Young Park; Sung-Chul Jung; Inho Jo; Woo-Jae Park; Joo-Won Park; et al. (Tissue Engineering and Regenerative Medicine, 2021)

In vitro and In vivo Antibacterial Effects of Nisin Against Streptococcus suis - Haodan Zhu; Lixiao Han; Yanxiu Ni; Zhengyu Yu; Dandan Wang; Junming Zhou; Bin Li; Wei Zhang; Kongwang He (Probiotics and Antimicrobial Proteins, 2021)

Recanalization Treatment for Acute Stroke: Can We Skip the Bridge? - Wen-Xiao Yu; Shu-Han Huang; Yan-Jiang Wang; Meng Zhang (Neuroscience Bulletin, 2021)

GTree: an Open-source Tool for Dense Reconstruction of Brain-wide Neuronal Population - Hang Zhou; Shiwei Li; Anan Li; Qing Huang; Feng Xiong; Ning Li; Jiacheng Han; Hongtao Kang; Yijun Chen; Yun Li; Huimin Lin; Yu-Hui Zhang; et al. (Neuroinformatics, 2021)

The prevalence and risks of major comorbidities among inpatients with pulmonary tuberculosis in China from a gender and age perspective: a large-scale multicenter observational study - Wanli Kang; Jian Du; Song Yang; Jiajia Yu; Hongyan Chen; Jianxiong Liu; Jinshan Ma; Mingwu Li; Jingmin Qin; Wei Shu; Peilan Zong; Yi Zhang; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Nitrogen Enrichment Reduces Nitrogen and Phosphorus Resorption Through Changes to Species Resorption and Plant Community Composition - Xiao-Tao Lü; Shuang-Li Hou; Sasha Reed; Jiang-Xia Yin; Yan-Yu Hu; Hai-Wei Wei; Zhi-Wei Zhang; Guo-Jiao Yang; Zhuo-Yi Liu; Xing-Guo Han (Ecosystems, 2021)

Marinobacter shengliensis subsp. alexandrii Subsp. Nov., Isolated from Cultivable Phycosphere Microbiota of Highly Toxic Dinoflagellate Alexandrium catenella LZT09 and Description of Marinobacter shengliensis Subsp. shengliensis Subsp. Nov - Xi Yang; Rong Xiang; Nurhezreen Md Iqbal; Yu-Han Duan; Xiao-Ai Zhang; Lei Wang; Lin-Zeng Yu; Jia-Zhou Li; Ming-Fei Sun; Qiao Yang; Chun-Tian Zheng; Shen-Quan Liao (Current Microbiology, 2021)

Soil and shrub differentially determine understorey herbaceous plant richness and abundance in a semi-arid riparian meadow - Dayong Han; Jifeng Wang; Jianaer Ahan; Yu Zhao; Yunfei Yang (Community Ecology, 2021)

A new method for wellbore stability evaluation based on fractured carbonate reservoir rock breaking degree - Houbin Liu; Shuai Cui; Yingfeng Meng; Xu Han; Teng Liu; Yu Fan; Ye Tao; Anran Yu (Arabian Journal of Geosciences, 2021)

EmhR is an indole‐sensing transcriptional regulator responsible for the indole‐induced antibiotic tolerance in Pseudomonas fluorescens - Jian‐Ting Han; Di‐Yin Li; Meng‐Yuan Zhang; Xiao‐Quan Yu; Xiang‐Xue Jia; Hang Xu; Xu Yan; Wen‐Juan Jia; Shaomin Niu; Megan L. Kempher; Xuanyu Tao; Yong‐Xing He (Environmental Microbiology, 2021)
Summary Indole is well known as an interspecies signalling molecule to modulate bacterial physiology; however, it is not clear how the indole signal is perceived and responded to by plant growth promoting rhizobacteria (PGPR) in the rhizosphere. Here, we demonstrated that indole enhanced the antibiotic tolerance of Pseudomonas fluorescens 2P24, a PGPR well known for its biocontrol capacity. Proteomic analysis revealed that indole influenced the expression of multiple genes including the emhABC operon encoding a major multidrug efflux pump. The expression of emhABC was regulated by a TetR‐family transcription factor EmhR, which was demonstrated to be an indole‐responsive regulator. Molecular dynamics simulation showed that indole allosterically affected the distance between the two DNA‐recognizing helices within the EmhR dimer, leading to diminished EmhR–DNA interaction. It was further revealed the EmhR ortholog in Pseudomonas syringae was also responsible for indole‐induced antibiotic tolerance, suggesting this EmhR‐dependent, indole‐induced antibiotic tolerance is likely to be conserved among Pseudomonas species. Taken together, our results elucidated the molecular mechanism of indole‐induced antibiotic tolerance in Pseudomonas species and had important implications on how rhizobacteria sense and respond to indole in the rhizosphere.

New secondary metabolite with cytotoxicity from spawning soft coral Asterospicularia laurae in Taiwan - Jui-Hsin Su; Chih-I Liu; Mei-Chin Lu; Chi-I Chang; Min-Ying Hsieh; Yu-Chi Lin; Chang-Feng Dai; Ya-Han Zhang; Zheng-Yu Lin; Yun-Sheng Lin (Natural Product Research, 2021)

Diagnostic incremental value of sputum in patients with pleural tuberculosis - Shuai Guo; Chao Han; Yu He; Mao-Shui Wang (Infectious Diseases, 2021)

Evolution Characteristics of Bulking Factor in the Multi-field Loading of Broken Coal: An Experimental Study - Xinlei Yang; Tingxiang Chu; Minggao Yu; Liang Wang; Jiangkun Chao; Xuefeng Han (Rock Mechanics and Rock Engineering, 2021)

At3g53630 encodes a GUN1-interacting protein under norflurazon treatment - Xing-Qi Huang; Lin-Juan Wang; Meng-Juan Kong; Na Huang; Xin-Ya Liu; Han-Yu Liang; Jia-Xin Zhang; Shan Lu (Protoplasma, 2021)

Cloning, characterization, and transcriptional activity of β-actin promoter of African catfish (Clarias gariepinus) - Sanghyok Ri; Wenho Hwang; Sangryong Ri; Wei Shi; Yu Han; Yu Tang; Lining Zhang; Maocang Yan; Guangxu Liu (Molecular Biology Reports, 2021)

The cellulose synthase (CesA) gene family in four Gossypium species: phylogenetics, sequence variation and gene expression in relation to fiber quality in Upland cotton - Sujun Zhang; Zhenxing Jiang; Jie Chen; Zongfu Han; Jina Chi; Xihua Li; Jiwen Yu; Chaozhu Xing; Mingzhou Song; Jianyong Wu; Feng Liu; Xiangyun Zhang; et al. (Molecular Genetics and Genomics, 2021)

GINS2 was regulated by lncRNA XIST/miR-23a-3p to mediate proliferation and apoptosis in A375 cells - Yu-Qin Hao; Ke-Wei Liu; Xin Zhang; Shu-Xia Kang; Kun Zhang; Wurihan Han; Li Li; Zhe-Hai Li (Molecular and Cellular Biochemistry, 2021)

Bioinformatics analysis of WRKY transcription factors in grape and their potential roles prediction in sugar and abscisic acid signaling pathway - Ting Huang; Jinli Yang; Dan Yu; Xiaoyu Han; Xiuqin Wang (Journal of Plant Biochemistry and Biotechnology, 2021)

Sri Lanka seasonal warm pools - Guoqing Han; Changming Dong; Jingsong Yang; Yu Liu (Journal of Oceanology and Limnology, 2021)

Delayed association of acute particulate matter 2.5 air pollution exposure with loss of complexity in cardiac rhythm dynamics: insight from detrended fluctuation analysis - Tsung-Ying Tsai; Li-Wei Lo; Shin-Huei Liu; Wen-Han Cheng; Yu-Hui Chou; Wei-Lun Lin; Yenn-Jiang Lin; Shih-Lin Chang; Yu-Feng Hu; Fa-Po Chung; Jo-Nan Liao; Tze-Fan Chao; et al. (Environmental Science and Pollution Research, 2021)

Long-term study of heavy metal pollution in the northern Hangzhou Bay of China: temporal and spatial distribution, contamination evaluation, and potential ecological risk - Hao Xu; Huahong Yang; Qiyun Ge; Zhenyi Jiang; Yang Wu; Yamei Yu; Deming Han; Jinping Cheng (Environmental Science and Pollution Research, 2021)

Fractionation of carbon isotopes of dissolved organic matter adsorbed to goethite in the presence of arsenic to study the origin of DOM in groundwater - Yanan Zhang; Yiqun Gan; Kai Yu; Li Han (Environmental Geochemistry and Health, 2021)

Polybrominated diphenyl ethers in soils from Tianjin, North China: distribution, health risk, and temporal trends - Yu Han; Jiali Cheng; Lei He; Minna Zhang; Shan Ren; Jiazheng Sun; Xiangyang Xing; Zhenwu Tang (Environmental Geochemistry and Health, 2021)

Effects of degradation succession of alpine wetland on soil organic carbon and total nitrogen in the Yellow River source zone, west China - Chun-ying Lin; Xi-lai Li; Jing Zhang; Hua-fang Sun; Juan Zhang; Hui-bang Han; Qi-hua Wang; Cheng-biao Ma; Cheng-yi Li; Yu-xing Zhang; Xue-qian Ma (Journal of Mountain Science, 2021)

Mechanisms of niche‐neutrality balancing can drive the assembling of microbial community - Lixiao Wang; Maozhen Han; Xi Li; Bingbing Yu; Huading Wang; Amjed Ginawi; Kang Ning; Yunjun Yan (Molecular Ecology, 2021)
One hotspot of present community ecology is to uncover the mechanisms of community succession. In this study, two popular concepts, niche‐neutrality dynamic balancing and co‐occurrence network analysis, were integrated to investigate the dispersal dynamics of microbial communities in a freshwater river continuum in subtropical China. Results showed that when habitat conditions were mild and appropriate, such as in the clean upstream river, free of heavy pollution or long‐lasting extreme disturbances, stochastic processes could increase species diversities, and organize communities into relatively loosely linked and stable networks with higher modularity and more modules. However, when conditions became degraded under heavy pollution, the influence of neutrality diminished, and niche‐based selection imposed more constraints on communities and guided the assembling processes in certain directions: depleting species richness, strengthening interspecies connections and breaking boundaries of modules. Consequently, communities became more sensitive to fluctuations so as to deal with the harsh conditions efficiently. Another interesting finding was that, both as keystone taxa of communities, module hubs were mostly neutrally distributed generalists with high abundances, and were beneficial to many related operational taxonomic units. In contrast, connectors were less abundant and their distributions were more subjected to the environments. Therefore, connectors were probably responsible for the information transmission between microbial communities and environments, as well as between different modules, and thus could restrict the dispersal of microbes and guide the direction of community assembly.

High-resolution distributions of O 2 / Ar on the northern slope of the South China Sea and estimates of net community production - Chuan Qin; Guiling Zhang; Wenjing Zheng; Yu Han; Sumei Liu (Ocean Science, 2021)
The dissolved oxygen-to-argon ratio (O2∕Ar) in the oceanic mixed layer has been widely used to estimate net community production (NCP), which is the difference between gross primary production and community respiration; it is a measure of the strength of the biological pump. In order to obtain the high-resolution distribution of NCP and improve our understanding of its regulating factors in the slope region of the northern South China Sea (SCS), we conducted continuous measurements of dissolved O2, Ar, and CO2 with membrane inlet mass spectrometry (MIMS) during two cruises in October 2014 and June 2015. An overall autotrophic condition was observed in the study region in both cruises with an average Δ(O2∕Ar) of 1.1 % ± 0.9 % in October 2014 and 2.7 % ± 2.8 % in June 2015. NCP was on average 11.5 ± 8.7 mmol C m−2 d−1 in October 2014 and 11.6 ± 12.7 mmol C m−2 d−1 in June 2015. Correlations between dissolved inorganic nitrogen (DIN), Δ(O2∕Ar), and NCP were observed in both cruises, indicating that NCP is subject to the nitrogen limitation in the study region. In June 2015, we observed a rapid response of the ecosystem to the episodic nutrient supply induced by eddies. Eddy-entrained shelf water intrusion, which supplied large amounts of terrigenous nitrogen to the study region, promoted NCP in the study region by potentially more than threefold. In addition, upwelling brought large uncertainties to the estimation of NCP in the core region of the cold eddy (cyclone) in June 2015. The deep euphotic depth in the SCS and the absence of correlation between NCP and the average photosynthetically available radiation (PAR) in the mixed layer in the autumn indicate that light availability may not be a significant limitation on NCP in the SCS. This study helps us to understand the carbon cycle in the highly dynamic shelf system.

Nitric Oxide Produced by the Antioxidant Activity of Verapamil Improves the Acute Wound Healing Process - Yu Na Han; Yoon Jae Lee; Ki Joo Kim; Su Jin Lee; Jang Youn Choi; Suk-Ho Moon; Jong Won Rhie (Tissue Engineering and Regenerative Medicine, 2021)

The adaptability of typical precipitation ensemble prediction systems in the Huaihe River basin, China - Han Wang; Ping-an Zhong; Fei-lin Zhu; Qing-wen Lu; Yu-fei Ma; Sun-yu Xu (Stochastic Environmental Research and Risk Assessment, 2021)

Study on the Triaxial Unloading Creep Mechanical Properties and Damage Constitutive Model of Red Sandstone Containing a Single Ice-Filled Flaw - Ren-liang Shan; Yao Bai; Yang Ju; Tian-yu Han; Hao-yu Dou; Zhao-long Li (Rock Mechanics and Rock Engineering, 2021)

Real-time detection of rice phenology through convolutional neural network using handheld camera images - Jingye Han; Liangsheng Shi; Qi Yang; Kai Huang; Yuanyuan Zha; Jin Yu (Precision Agriculture, 2021)

The ankyrin repeat-containing protein MdANK2B regulates salt tolerance and ABA sensitivity in Malus domestica - Fu-jun Zhang; Yin-huan Xie; Han Jiang; Xun Wang; Yu-Jin Hao; Zhenlu Zhang; Chun-Xiang You (Plant Cell Reports, 2021)

Curcumin protects thymus against D-galactose-induced senescence in mice - Jie-han Li; Ting-ting Wei; Li Guo; Jia-hui Cao; Yuan-kang Feng; Shu-ning Guo; Guo-hong Liu; Yi Ding; Yu-rong Chai (Naunyn-Schmiedeberg's Archives of Pharmacology, 2021)

Diversity-oriented synthesis and antifungal activities of novel pimprinine derivative bearing a 1,3,4-oxadiazole-5-thioether moiety - Zi-Long Song; Yun Zhu; Jing-Rui Liu; Shu-Ke Guo; Yu-Cheng Gu; Xinya Han; Hong-Qiang Dong; Qi Sun; Wei-Hua Zhang; Ming-Zhi Zhang (Molecular Diversity, 2021)