Effects of land clearing for agriculture on soil organic carbon stocks in drylands: A meta‐analysis - Yuangang Wang; Geping Luo; Chaofan Li; Hui Ye; Haiyang Shi; Binbin Fan; Wenqiang Zhang; Chen Zhang; Mingjuan Xie; Yu Zhang (Global Change Biology, 2023)
Agricultural activities have been expanding globally with the pressure to provide food security to the earth's growing population. These agricultural activities have profoundly impacted soil organic carbon (SOC) stocks in global drylands. However, the effects of clearing natural ecosystems for cropland (CNEC) on SOC are uncertain. To improve our understanding of carbon emissions and sequestration under different land uses, it is necessary to characterize the response patterns of SOC stocks to different types of CNEC. We conducted a meta‐analysis with mixed‐effect model based on 873 paired observations of SOC in croplands and adjacent natural ecosystems from 159 individual studies in global drylands. Our results indicate that CNEC significantly ( p p −1 ). The results derived from our meta‐analysis could be used for refining the estimation of dryland carbon dynamics and developing SOC sequestration strategies to achieve the removal of CO 2 from the atmosphere.

BMSCs-derived Mitochondria Improve Osteoarthritis by Ameliorating Mitochondrial Dysfunction and Promoting Mitochondrial Biogenesis in Chondrocytes - Mingchuan Yu; Di Wang; Xiang Chen; Da Zhong; Jun Luo (Stem Cell Reviews and Reports, 2022)

Short-term exposure to fine particulate matter constituents and mortality: case-crossover evidence from 32 counties in China - Peixuan Zhou; Jianlin Hu; Chuanhua Yu; Junzhe Bao; Siqi Luo; Zhihao Shi; Yang Yuan; Shaocai Mo; Zhouxin Yin; Yunquan Zhang (Science China Life Sciences, 2022)

Shanghai Autism Early Development: An Integrative Chinese ASD Cohort - Yuan Dai; Yuqi Liu; Lingli Zhang; Tai Ren; Hui Wang; Juehua Yu; Xin Liu; Zilin Chen; Lin Deng; Minyi Tao; Hangyu Tan; Chu-Chung Huang; et al. (Neuroscience Bulletin, 2022)

Talaromyces marneffei Infections in 8 Chinese Children with Inborn Errors of Immunity - Linlin Wang; Ying Luo; Xiaolin Li; Yixian Li; Yu Xia; Tingyan He; Yanyan Huang; Yongbin Xu; Zhi Yang; Jiayun Ling; Ruohang Weng; Xiaona Zhu; et al. (Mycopathologia, 2022)
Purpose Talaromyces marneffei (TM) is an opportunistic fungus leading to multi-organ damages and poor prognosis in immunocompromised individuals. TM infections in children are rare and our knowledge to TM infection is insufficient. To investigate the clinical characteristics of TM-infected children and to explore the underlying mechanisms for host against TM, we analysed TM-infected patients diagnosed in our hospital. Methods Eight patients with TM infections have been identified in Shenzhen Children’s Hospital during 2017–2021. Clinical data were collected from medical records. Immunological features were evaluated by flow cytometry. Literatures were also reviewed to summarize the reported inborn errors of immunity (IEIs) with TM infections. Results All 8 children were HIV-negative. The most common symptom of TM infections was fever (8/8), followed by weight loss (7/8), pneumonia (7/8), hepatomegaly (7/8), splenomegaly (6/8), anemia (6/8), lymphadenopathy (5/8), thrombocytopenia (3/8), diarrhea (3/8), rashes or skin lesions (3/8), and osteolytic lesions (1/8). Five children died during the follow-ups. CD3+ T cells were decreased in 6 patients. Eight patients had reduced natural killer cells. All patients went gene sequencing and were finally diagnosed as IEIs, including STAT1 gain-of-function, IL-2 receptor common gamma chain deficiency, adenosine deaminase deficiency, CD40 ligand deficiency, and STAT3 deficiency. Another 4 types of IEIs (CARD9, IFN- γ receptor 1, RelB, and NFKB2 deficiency), have been reported with TM infections based on literature review. Conclusion TM infections resulted in systemic injuries and high mortality. The spectrum of IEIs underlying TM infections indicated that T cell-mediated immunity, IFN- γ , IL-17 signalings and NF-κB pathways were important for host responses against TM infection. In reverse, for HIV-negative children without other secondary immunodeficiencies, IEIs should be considered in TM-infected children.

Genome-Wide Association Study Reveals SNPs and Candidate Genes Related to Growth and Body Shape in Bighead Carp (Hypophthalmichthys nobilis) - Geng Chen; Ying Zhou; Xiaomu Yu; Junru Wang; Weiwei Luo; Meixia Pang; Jingou Tong (Marine Biotechnology, 2022)

Improvement of Tea Yield and Quality by Chicken Manure and Wine Lees (CMWL) Substitution for Chemical Fertilizers in the Hilly Region of Western Sichuan, China - Ludan Chen; Wei Zhou; Shirong Zhang; Liangji Deng; Ouping Deng; Ling Luo; Xiaoxun Xu; Chaowu Yang; Chunlin Yu (Journal of Soil Science and Plant Nutrition, 2022)

Hydrogen Sulfide Inhibits Cadmium-Induced Cell Death of Cucumber Seedling Root Tips by Protecting Mitochondrial Physiological Function - Shilei Luo; Zhongqi Tang; Jihua Yu; Weibiao Liao; Jianming Xie; Jian Lv; Zeci Liu; Alejandro Calderón-Urrea (Journal of Plant Growth Regulation, 2022)
Hydrogen sulfide (H 2 S) can alleviate Cd-induced cell death, but the molecular mechanisms are not clear. To shed light on these mechanisms, cell death induced by 200 μM cadmium chloride in cucumber seedlings root tips was used as a model system. Here, we report that the negative effect of Cd stress in mitochondrial physiological functions include changes in cytochrome c/a, mitochondrial membrane permeability transition pores, and adenosine triphosphatase (ATPase). Moreover, Cd stress led to the release of mitochondrial Ca 2+ into the cytosol. Exogenous application of sodium hydrosulfide (NaHS, a donor of H 2 S) inhibited cell death and maintains mitochondrial function by reducing mitochondrial hydrogen peroxide accumulation, increasing ATPase activity and down-regulating CsVDAC and CsANT expression. In summary, H 2 S suppressed Cd-induced cell death by improving mitochondrial physiological properties.

Low-Level Environmental Per- and Polyfluoroalkyl Substances and Preterm Birth: A Nested Case–Control Study Among a Uyghur Population in Northwestern China - Bo-Yi Yang; Jianhua Wu; Xilong Niu; Chuanjiang He; Michael S. Bloom; Maihefuzaimu Abudoukade; Mairiyemu Abulizi; Aimin Xu; Beibei Li; Li Li; Xuemei Zhong; Qi-Zhen Wu; et al. (Exposure and Health, 2022)

Correction to: Spatial pattern of the effects of human activities on the land surface of China and their spatial relationship with the natural environment - Shuling Hu; Bin Yu; Shen Luo; Rongrong Zhuo (Environment, Development and Sustainability, 2022)

Compensatory thalamocortical functional hyperconnectivity in type 2 Diabetes Mellitus - Jie Wang; Shanlei Zhou; Datong Deng; Mimi Chen; Huanhuan Cai; Cun Zhang; Fujun Liu; Wei Luo; Jiajia Zhu; Yongqiang Yu (Brain Imaging and Behavior, 2022)

CW198 acts as a genetic insulator to block enhancer-promoter interaction in plants - Li Jiang; Yue Liu; Zhifeng Wen; Yingjun Yang; Stacy D. Singer; Dennis Bennett; Wenying Xu; Zhen Su; Zhifang Yu; Josh Cohn; Xi Luo; Zhongchi Liu; et al. (Transgenic Research, 2022)

Investigation of a Method to Prevent Rock Failure and Disaster Due to a Collapse Column Below the Mine - Bo Ren; Liang Yuan; Wenqiang Mu; Yongshu Zhang; Guofeng Yu; Chengping Cao; Minhua Wang; Yong Luo; Lianchong Li (Mine Water and the Environment, 2022)

Dynamic Changes of Transcriptome and Metabolites During Ripening of Alpinia Oxyphylla Fruit (AOF) - Kun Pan; Xiaodan Yu; Shujuan Wang; Jie Hou; Yuchao Luo; Bingmiao Gao (Journal of Plant Biology, 2022)

Enhanced biodegradation of oil-contaminated soil oil in shale gas exploitation by biochar immobilization - Hongyang Ren; Yuanpeng Deng; Liang Ma; Zijing Wei; Lingli Ma; Demin Yang; Bing Wang; Zheng-Yu Luo (Biodegradation, 2022)

The Seasonal and Stage-Specific Expression Patterns of HMGB2 Suggest Its Key Role in Spermatogenesis in the Chinese Soft-Shelled Turtle (Pelodiscus sinensis) - Wei Li; Junxian Zhu; Luo Lei; Chen Chen; Xiaoli Liu; Yakun Wang; Xiaoyou Hong; Lingyun Yu; Hongyan Xu; Xinping Zhu (Biochemical Genetics, 2022)

Exploring the Wenchuan earthquake fault through the accurate location of WFSD-4# Well using seismic reflection - Yang-Yang Feng; Chang-Qing Yu; Hai-Bing Li; Chen Qu; Chan Wu; Qi Wang; Su Luo; Jin-Peng Huang; Ghazi Rehana (Applied Geophysics, 2022)

First Detection and Molecular Identification of Entamoeba bovis in Farm-Raised Sika Deer from Anhui Province, China - Xin-chao Liu; Qi Ren; Jie Guo; Dong-qian Chen; Qiao-qiao Li; Xin-yu Luo; You-fang Gu; Wen-chao Li (Acta Parasitologica, 2022)

Evaluation of the Anti-Inflammatory Activity of Enzymatic Hydrolysis Peptide SEP-3 from Skipjack ( Katsuwonus pelamis ) Based on NF-κB and MAPK Pathways - Chong Yi; Yue Wu; Zhi-gao Wang; Kun-mei Wang; Ze-kun Zhang; Bin Wang; Hong-yu Luo (Journal of Aquatic Food Product Technology, 2022)

Habitat decline of the largest known Indo-Pacific humpback dolphin (Sousa chinensis) population in poorly protected areas associated with the hypoxic zone - Lang Guo; Dingyu Luo; Ri-Qing Yu; Chen Zeng; Nuoyan Huang; Hongri Wang; Yuping Wu (Frontiers in Marine Science, 2022)
Reserve planning based on the investigation of the core habitat distribution of wild cetaceans is a powerful conservation strategy for protecting target species. However, studies on core habitats and their variations at the large-scale distribution of cetaceans are limited. In this study, we conducted a seven years (2015-2021) boat-based field observation surveys with highly applicable and generalized methods to analyze the habitat changes and how these changes influenced the largest known Indo-Pacific humpback dolphin ( Sousa chinensis ) population in the Pearl River Estuary (PRE), China. Our findings revealed that there is 3204 km 2 of dolphin habitat in the PRE, and dolphin distribution preferences are related to nutrients and biological resources. The decreasing trend of dolphin sighting rates in most areas (73.2%) indicated that the dolphin habitat had declined, and the annual habitat decline rate (2.83%; 95% confidence interval: 0.58%-5.08%) was consistent with the population decline rate. The annual habitat decline rate in the hypoxic zone revealed that low dolphin sighting rates from March to October in the hypoxic zone was 0.43% faster than that in the non-hypoxic zone, indicating long-term sustained effects of summer hypoxia on the dolphin population. Existing reserves have partially prevented habitat decline. However, more than 82.3% of the habitat has not been effectively protected and encounters the threats of pollution and hypoxic stress. This study offers new scientific evidence for developing effective monitoring strategies for humpback dolphin populations in the PRE, and also help establish spatial planning and management measures for reserve habitats.

Mulberry leaf extract improves non-specific immunity and antioxidant capacity of largemouth bass (Micropterus salmoides) fed a high-starch diet - Jing Tingsen; Luo Hui; Huang Junwa; Li Zhe; Li Yu; Jin Honghao; Zou Xinxi; Ke Zhenlin; Sun Wenbo; Hou Mengdan; Yang Huijun; Ye Hua (Frontiers in Marine Science, 2022)
A 70-day experiment was conducted to investigate the effects of mulberry leaf extract (MLE) on growth, proximate compositions, antioxidant and plasma biochemical parameters, and indices of non-specific immunity of largemouth bass ( Micropterus salmoides ) fed a high-starch diet. Two hundred eighty largemouth bass (initial body weight, 68.00 ± 0.19 g) were randomly fed seven diets: basal-starch diet (BSD; 8.88% starch), high-starch diet (HSD; 11.42% starch), and HSD diets supplemented with 0.05%, 0.10%, 0.20%, 0.50%, and 1.00% MLE (MLE1, MLE2, MLE3, MLE4, and MLE5, respectively). The results indicated that HSD and MLE did not significantly affect the growth performance of largemouth bass during the experimental period compared with that of the BSD, but the supplementation with more than 0.20% (MLE3, MLE4, and MLE5) MLE significantly decreased the hepatosomatic index (HSI) values, and 1.00% (MLE5) MLE significantly decreased the viscerosomatic index (VSI) values. The whole-body moisture of fish fed an HSD decreased significantly, while the whole-body lipid content increased significantly in the HSD group compared with the BSD group. Compared with HSD, MLE supplementation significantly decreased the moisture and lipid contents in the whole body. Supplementation with more than 0.20% MLE (MLE3, MLE4, and MLE5) significantly decreased the moisture content in the muscle. Supplementation with 1.00% MLE significantly decreased the content of hepatic and muscle glycogen. The malondialdehyde (MDA) content of the HSD group was significantly increased compared to that of the BSD group, whereas more than 0.10% (MLE2, MLE3, MLE4, and MLE5) MLE significantly decreased the MDA content. Additionally, the total antioxidant capacity (T-AOC), catalase (CAT), and glutathione peroxidase (GSH-Px) activities of MLE5 were significantly higher than those of the HSD group. The complement-3 (C3) content and globulin (GLB) in the plasma of the HSD group were significantly lower than those of the BSD group. Plasma C3 levels in the MLE3, MLE4, and MLE5 groups were significantly higher than those in the HSD group. In addition, glucose (GLU) levels in the MLE3, MLE4, and MLE5 groups were significantly lower than those in the HSD group. Supplementation with 0.50% (MLE4) MLE significantly increased the lysozyme (LYZ) content and decreased the activities of alanine transaminase (ALT) and aspartate transaminase (AST). Supplementation with 1.00% MLE significantly increased complement-4 (C4) and GLB contents and alkaline phosphatase (ALP) activity. Overall, these findings suggest that MLE could improve antioxidant capacity, immune function, and glycolipid metabolism, thereby alleviating the negative effects of a high-starch diet in M. salmoides .

LncRNA Tug1 Contributes Post-stroke NLRP3 Inflammasome-Dependent Pyroptosis via miR-145a-5p/Tlr4 Axis - Meiling Yao; Ying Luo; Hongjie Li; Songjie Liao; Jian Yu (Molecular Neurobiology, 2022)

Damage Constitutive and Failure Prediction of Artificial Single-Joint Sandstone Based on Acoustic Emission - Bing Sun; Haowei Yang; Sheng Zeng; Yu Luo (Geotechnical and Geological Engineering, 2022)

Urinary concentrations of polycyclic aromatic hydrocarbon and phthalate metabolite mixtures in relation to semen quality among men attending an infertility clinic - Yan-Ling Deng; Pan Yang; Yi-Xin Wang; Chong Liu; Qiong Luo; Tian Shi; Jia-Yue Zeng; Ting-Ting Lu; Pan-Pan Chen; Yu Miao; Min Zhang; Fei-Peng Cui; et al. (Environmental Science and Pollution Research, 2022)

Liming and nitrification inhibitor affects crop N uptake efficiency and N loss through changing soil N processes - Baoling Guo; Xiangzhou Zheng; Juhua Yu; Hong Ding; Shezhou Luo; Alison Carswell; Tom Misselbrook; Jinbo Zhang; Christoph Müller; Jinquan Shen; Yushu Zhang (Biology and Fertility of Soils, 2022)

Visualization and quantification of carbon “rusty sink” by rice root iron plaque: Mechanisms, functions, and global implications - Liang Wei; Zhenke Zhu; Bahar S. Razavi; Mouliang Xiao; Maxim Dorodnikov; Lichao Fan; Hongzhao Yuan; Andrey Yurtaev; Yu Luo; Weiguo Cheng; Yakov Kuzyakov; Jinshui Wu; et al. (Global Change Biology, 2022)
Paddies contain 78% higher organic carbon (C) stocks than adjacent upland soils, and iron (Fe) plaque formation on rice roots is one of the mechanisms that traps C. The process sequence, extent and global relevance of this C stabilization mechanism under oxic/anoxic conditions remains unclear. We quantified and localized the contribution of Fe plaque to organic matter stabilization in a microoxic area (rice rhizosphere) and evaluated roles of this C trap for global C sequestration in paddy soils. Visualization and localization of pH by imaging with planar optodes, enzyme activities by zymography, and root exudation by 14 C imaging, as well as upscale modeling enabled linkage of three groups of rhizosphere processes that are responsible for C stabilization from the micro‐ (root) to the macro‐ (ecosystem) levels. The 14 C activity in soil (reflecting stabilization of rhizodeposits) with Fe 2+ addition was 1.4–1.5 times higher than that in the control and phosphate addition soils. Perfect co‐localization of the hotspots of β‐glucosidase activity (by zymography) with root exudation ( 14 C) showed that labile C and high enzyme activities were localized within Fe plaques. Fe 2+ addition to soil and its microbial oxidation to Fe 3+ by radial oxygen release from rice roots increased Fe plaque (Fe 3+ ) formation by 1.7–2.5 times. The C amounts trapped by Fe plaque increased by 1.1 times after Fe 2+ addition. Therefore, Fe plaque formed from amorphous and complex Fe (oxyhydr)oxides on the root surface act as a “rusty sink” for organic matter. Considering the area of coverage of paddy soils globally, upscaling by model revealed the radial oxygen loss from roots and bacterial Fe oxidation may trap up to 130 Mg C in Fe plaques per rice season. This represents an important annual surplus of new and stable C to the existing C pool under long‐term rice cropping.

Global pattern of soil priming effect intensity and its environmental drivers - Fei Mo; Chengjie Ren; Kailiang Yu; Zhenghu Zhou; Richard P. Phillips; Zhongkui Luo; Yeye Zhang; Yuteng Dang; Juan Han; Jian‐Sheng Ye; Nangia Vinay; Yuncheng Liao; et al. (Ecology, 2022)
The microbial priming effect—the decomposition of soil organic carbon (SOC) induced by plant inputs—has long been considered an important driver of SOC dynamics, yet we have limited understanding about the direction, intensity, and drivers of priming across ecosystem types and biomes. This gap hinders our ability to predict how shifts in litter inputs under global change can affect climate feedbacks. Here, we synthesized 18,919 observations of CO 2 effluxes in 802 soils across the globe to test the relative effects (i.e., log response ratio [RR]) of litter additions on native SOC decomposition and identified the dominant environmental drivers in natural ecosystems and agricultural lands. Globally, litter additions enhanced native SOC decomposition (RR = 0.35, 95% CI: 0.32–0.38), with greater priming effects occurring with decreasing latitude and more in agricultural soils (RR = 0.43) than in uncultivated soils (RR = 0.28). In natural ecosystems, soil pH and microbial community composition (e.g., bacteria: fungi ratio) were the best predictors of priming, with greater effects occurring in acidic, bacteria‐dominated sandy soils. In contrast, the substrate properties of plant litter and soils were the most important drivers of priming in agricultural systems since soils with high C:N ratios and those receiving large inputs of low‐quality litter had the highest priming effects. Collectively, our results suggest that, though different factors may control priming effects, the ubiquitous nature of priming means that alterations of litter quality and quantity owing to global changes will likely have consequences for global C cycling and climate forcing.

Could partial nonstarch polysaccharides ameliorate cancer by altering m 6 A RNA methylation in hosts through intestinal microbiota? - Jianming Luo; Juntong Yu; Xichun Peng (Critical Reviews in Food Science and Nutrition, 2022)

Associations of metal profiles in blood with thyroiditis: a cross-sectional study - Yaosheng Luo; Huixian Zeng; Yanshi Ye; Genfeng Yu; Cheng Song; Siyang Liu; Xingying Chen; Yuqi Jiang; Hualin Duan; Yue Li; Shengqing He; Zhi Chen; et al. (Environmental Science and Pollution Research, 2022)
Autoimmune thyroiditis (AIT) is increasingly common, and serological markers include thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb). To determine if selected metals influence thyroiditis antibody positivity, this cross-sectional study investigated associations between metals and thyroiditis antibody status. Healthy individuals ( n = 1104) completed a questionnaire and underwent checkups of anthropometric parameters, thyroid function status, and levels of seven metals in blood (magnesium, iron, calcium, copper, zinc, manganese, and lead). Associated profiles of glyco- and lipid metabolism were also established. Logistic regression and restricted cubic spline (RCS) regression analysis were applied to adjudge associations between metals and TPOAb and TgAb status. It was found that, after adjusting for likely cofounding factors, participants with antibody positivity had significantly lower serum concentrations of magnesium and iron. When serum magnesium levels were analyzed in quartiles, the odds ratios of quartile 4 were 0.329–fold (95% confidence interval (CI): 0.167–0647) and 0.259-fold (95% CI 0.177–0.574) that of quartile 1 regarding TPOAb and TgAb positivity ( P = 0.004, 0.003). After adjustment, the RCS analysis detected nonlinear associations between iron and TPOAb and TgAb positivity ( P < 0.01, both). In stratified analyses, these associations regarding magnesium and iron remained for women of reproductive age, but not for postmenopausal women and men. We conclude that lower serum levels of magnesium and iron are associated with incremental positivity of thyroiditis antibodies and may be among the most important metals contributing to AIT in women of reproductive age.

Three pairs of sesquiterpene enantiomers from Chloranthus multistachys pei - Wei-ming Huang; Fang-you Chen; Yu-ting Bian; Tian-jiao Ning; Zhi-chao Chen; Peng-cheng Shuang; Yong-ming Luo (Natural Product Research, 2022)

Impacts of Mesoscale Eddies on Biogeochemical Variables in the Northwest Pacific - Jianhua Kang; Yu Wang; Shuhong Huang; Lulu Pei; Zhaohe Luo (Journal of Marine Science and Engineering, 2022)
Mesoscale eddies play an important role in regulating biogeochemical cycles. However, the response of biogeochemical variables to cold and warm eddies has not been well elucidated, mainly due to most previous studies relying on remote sensing techniques and lacking in situ observations below the surface water. Here, we used hydrographic and biochemical data from one survey in the northwestern Pacific to document the vertical biogeochemical structure of one cold and two warm eddies. We first compared the changes of key variables in the eddy core relative to eddy outside, explained the role of key layers (the mixing depth, pycnocline, nutricline, euphotic) in causing these changes, and then analyzed the main environmental factors affecting chlorophyll a (Chla) and phytoplankton communities. Finally we focused on the response mechanisms of key biogeochemical variables to the cold and warm eddies. The results showed that biological variables (Chla, microphytoplankton, picophytoplankton), salinity, dissolved inorganic nitrogen (DIN), dissolved inorganic phosphate (DIP), and dissolved inorganic silicate (DSi) in the cold eddy core increased by 0.2–134%, while in the warm eddy core, they decreased by 0.2–70% relative to the eddy outside. The cold and warm eddies were able to force the deep chlorophyll maximum (DCM), which rose or fell with the pycnocline, nutricline and euphotic depth (Zeu) as a whole. Cold eddies with a raised thermocline could lead to about 20 m elevated DCM and enhanced phytoplankton biomass when the nutricline and thermocline were coincident. In contrast, warm eddies drove isopycnals downward, resulting in a 10–25 m drop in DCM and a decrease in nutrient and Chla concentrations at the center of the eddies. The significant difference in the vertical structure of the phytoplankton community between the center and the outside of the eddy might be explained by the direct influence of both nutrient concentrations and stoichiometry changes. The contribution of microphytoplankton to total biomass was much smaller than that of picophytoplankton in oligotrophic waters where the DIN:DIP and DSi:DIN ratios are significantly low. Compared to nutrients, photosynthetically active radiation (PAR) might not be the main factor controlling phytoplankton biomass and abundance attributed to Zeu being consistently deeper than the mixed depth (Zm), whereas it was likely to be the key limiting factor affecting the vertical distribution of the phytoplankton community.

Disruption of Sonic Hedgehog Signaling Accelerates Age-Related Neurogenesis Decline and Abolishes Stroke-Induced Neurogenesis and Leads to Increased Anxiety Behavior in Stroke Mice - Jiapeng Wang; Kierra Ware; Alicia Bedolla; Emily Allgire; Flavia Correa Turcato; Maxwell Weed; Renu Sah; Yu Luo (Translational Stroke Research, 2022)

Effects of Immune Cells on Intestinal Stem Cells: Prospects for Therapeutic Targets - Liyun Ma; Jianghong Yu; Huilu Zhang; Bing Zhao; Jun Zhang; Dongqin Yang; Feifei Luo; Bangting Wang; Bohan Jin; Jie Liu (Stem Cell Reviews and Reports, 2022)

Lower abundance of Bacteroides and metabolic dysfunction are highly associated with the post-weaning diarrhea in piglets - Wen Ren; Bing Yu; Jie Yu; Ping Zheng; Zhiqing Huang; Junqiu Luo; Xiangbing Mao; Jun He; Hui Yan; Jinlong Wu; Daiwen Chen; Yuheng Luo (Science China Life Sciences, 2022)

Comparative Transcriptome and Hormone Analysis of Mature Leaves and New Shoots in Tea Cuttings (Camellia sinensis) among Three Cultivars with Different Rooting Abilities - Kai Fan; Yujie Shi; Danni Luo; Wenjun Qian; Jiazhi Shen; Shibo Ding; Zhaotang Ding; Yu Wang (Journal of Plant Growth Regulation, 2022)

The different deletion mutation in the phenylalanine ammonia-lyase (PAL) gene affects the peel color of mango (Mangifera indica L.) - Zhichang Zhao; Aiping Gao; Ruixiong Luo; Kuanliang Liu; Kaili Yu (Genetic Resources and Crop Evolution, 2022)

Identification of resistance of Guangxi (Oryza rufipogon Griff.) to white-backed planthopper with stem evaluation method - Xin-ying Guo; Xuan Wang; Liang Luo; Yao-yu Fang; Kai-chong Teng; Neng Zhao; Jin-lian Yang; Fang Liu; Bao-xiang Qin; Ji-jing Luo; Rong-bai Li (Genetic Resources and Crop Evolution, 2022)

Settleability and dewaterability of sewage sludge with modified diatomite - Ling-Yu Wang; Xue Li; Kun Luo; Yu-Hao Song; Ren-Guo Liu (Environmental Science and Pollution Research, 2022)

Aberrant brain connectivity is associated with childhood maltreatment in individuals with major depressive disorder - Qianyi Luo; Juran Chen; Yuhong Li; Zhiyao Wu; Xinyi Lin; Jiazheng Yao; Huiwen Yu; Huawang Wu; Hongjun Peng (Brain Imaging and Behavior, 2022)

White matter connectometry in patients with disorders of consciousness revealed by 7-Tesla magnetic resonance imaging - Xufei Tan; Zhen Zhou; Jian Gao; Yamei Yu; Ruili Wei; Benyan Luo; Xiaotong Zhang (Brain Imaging and Behavior, 2022)

An Unprecedented Record Low Antarctic Sea-ice Extent during Austral Summer 2022 - Jinfei Wang; Hao Luo; Qinghua Yang; Jiping Liu; Lejiang Yu; Qian Shi; Bo Han (Advances in Atmospheric Sciences, 2022)

Comparative insights into influences of co-contamination by rare-earth elements and heavy metals on soil bacterial and fungal communities - Ying Luo; Duo Zhang; Ying Guo; Shao-hua Zhang; Le-le Chang; Yu Qi; Xian-hua Li; Jian-guo Liu; Wei Guo; Ji Zhao; Zhi-hua Bao (Journal of Soils and Sediments, 2022)

Screening of nanobody against Microcystis from a human phage display nanobody library - Yao Zu; Wenjie Miao; Yu Luo; Chen Xu; Qianhui Pan; Siyu Chen; Jianhong Li (Journal of Oceanology and Limnology, 2022)

Environmental thallium exposure and the risk of early embryonic arrest among women undergoing in vitro fertilization: thallium exposure and polymorphisms of mtDNA gene interaction and potential cause exploring - Chunmei Liang; Guiying Luo; Yu Cao; Danyang Li; Lingchao Shen; Zhikang Zhang; Tingting Jiang; Kai Zong; Dan Liang; Weiwei Zou; Xiaofeng Xu; Yajing Liu; et al. (Environmental Science and Pollution Research, 2022)

Decreasing arsenic accumulation but promoting arsenate biotransformation in Microcystis aeruginosa regulated by nano-Fe2O3 - Yan Chen; Zhenhong Wang; Zhuanxi Luo; Yao Zhao; Jincong Yu (Environmental Science and Pollution Research, 2022)

Fractional contribution of global warming and regional urbanization to intensifying regional heatwaves across Eurasia - Gang Wang; Qiang Zhang; Ming Luo; Vijay P. Singh; Chong-Yu Xu (Climate Dynamics, 2022)

Paleo-karst zone and its control on reservoirs in the fourth member of the Sinian Dengying formation in the Moxi area, central Sichuan Basin - Qinyu Xia; Haijun Yan; Wei Xu; Lin Zhang; Qian Li; Wenjun Luo; Hui Deng; Xun Zhu; Xinyu Li; Jichen Yu (Carbonates and Evaporites, 2022)

Spatial variability in the abundance and prey selection of the corallivorous snail Drupella spp. in the southeastern Hainan Island, China - Xinming Lei; Chengyue Liu; Yuyang Zhang; Xiaolei Yu; Jianhui Yang; Yong Luo; Guowei Zhou; Hui Huang (Frontiers in Marine Science, 2022)
Global climate change has caused extensive loss of biodiversity and ecosystem function globally, particularly in coral reefs in shallow tropical waters. As the corallivorous snails represent considerable disturbances to coral reefs across Indo-Pacific region, it is becoming a threat to coral health and recovery in the Hainan Island, South China Sea, but current-knowledge gap remains on the spatial distribution, prey preferences, and the influence factors related. Thus, we investigated the abundance distribution of Drupella spp. in relation to coral-prey selectivity, availability, and nutritional value. The snail density was heterogeneously distributed in the study area with an average of 0.72 ± 0.32 ind m −2 (varying from 0.09 ± 0.03 to 1.78 ± 0.39 ind m −2 ), and the snail density was found generally higher in locations with higher coral cover, which resulted in much lower density where their preferred corals became scarce. Despite the snails showing a positive preference for Acroporidae corals, they displayed dietary plasticity by changing with prey abundance and availability. Further, we found the electivity index of the coral prey related to the substrate types, and the nutritional value of prey was an additional important determinant in the prey preference, suggesting that the specific reef habitat and environmental context may alter the prey preference of Drupella spp. Combined, these results provide preliminary evidence that Drupella spp. is among the common corallivories in the reef regions of Hainan Island, and we recommend that large-scale monitoring programs assess the spatial-temporal trends to better understand the dynamics of predation linked to both anthropogenic and natural impacts.

CREB1 contributes colorectal cancer cell plasticity by regulating lncRNA CCAT1 and NF-κB pathways - Bin Li; Lisi Zheng; Jiayi Ye; Chenmin Zhang; Jie Zhou; Qiaojuan Huang; Yanhua Guo; Luqin Wang; Peng Yu; Shurong Liu; Qiao Lin; Yuxia Luo; et al. (Science China Life Sciences, 2022)

The role of melatonin in tomato stress response, growth and development - Qiaoli Xie; Yu Zhang; Yingxia Cheng; Yanling Tian; Junjie Luo; Zongli Hu; Guoping Chen (Plant Cell Reports, 2022)

Fbxw17 is dispensable for viability and fertility in mice - Zhen Chen; Dupeng Ma; Tingyu Jin; Ziqi Yu; Jiong Li; Qi Sun; Zejia Li; Ziye Du; Rong Liu; Yi Li; Mengcheng Luo (Molecular Biology Reports, 2022)

HDAC inhibitor chidamide synergizes with venetoclax to inhibit the growth of diffuse large B-cell lymphoma via down-regulation of MYC, BCL2, and TP53 expression - Cancan Luo; Tiantian Yu; Ken H. Young; Li Yu (Journal of Zhejiang University-SCIENCE B, 2022)

Case series of congenital pseudarthrosis of the tibia unfulfilling neurofibromatosis type 1 diagnosis: 21% with somatic NF1 haploinsufficiency in the periosteum - Yu Zheng; Guanghui Zhu; Yaoxi Liu; Weihua Zhao; Yongjia Yang; Zhenqing Luo; Yuyan Fu; Haibo Mei; Zhengmao Hu (Human Genetics, 2022)

Inversion of hydrogeological parameters based on an adaptive dynamic surrogate model - Yong Liu; Jiannan Luo; Yu Xiong; Yeifei Ji; Xin Xin (Hydrogeology Journal, 2022)

Occurrence characteristics and health risk assessment of per- and polyfluoroalkyl substances from water in residential areas around fluorine chemical industrial areas, China - Jiaxi Tang; Yongle Zhu; Yu Li; Biao Xiang; Ting Tan; Linyou Lv; Qing Luo (Environmental Science and Pollution Research, 2022)

Immobilization of mercury in tailings originating from the historical artisanal and small-scale gold mining using sodium polysulfide - Yu Wang; Zhiqiang Luo; Danqing Liu; Yilian Li (Environmental Science and Pollution Research, 2022)

Effects of vegetation succession on soil organic carbon fractions and stability in a karst valley area, Southwest China - Yuxi Luo; Yixuan Li; Shiwei Liu; Pujia Yu (Environmental Monitoring and Assessment, 2022)

Spatial pattern of the effects of human activities on the land surface of China and their spatial relationship with the natural environment - Shuling Hu; Bin Yu; Shen Luo; Rongrong Zhuo (Environment, Development and Sustainability, 2022)

Heavy metals in road dust across China: occurrence, sources and health risk assessment - Fei Huang; Baolin Liu; Yong Yu; Linyang Lv; Xinyu Luo; Fangyuan Yin (Bulletin of Environmental Contamination and Toxicology, 2022)

Cause-Effect Relationship between Meso-γ-Scale Rotation and Extreme Short-Term Precipitation: Observational Analyses at Minute and Sub-Kilometer Scales - Qiuyang Zhang; Yali Luo; Ying Tang; Xin Xu; Shuting Yu; Chong Wu (Journal of Meteorological Research, 2022)

Residents’ urbanized landscape preferences in rural areas reveal the importance of naturalness-livability contrast - Gaoyuan Yang; Zhaowu Yu; Tao Luo; Søderkvist Kristensen Lone (Journal of Geographical Sciences, 2022)

The global biogeography of soil priming effect intensity - Chengjie Ren; Fei Mo; Zhenghu Zhou; Felipe Bastida; Manuel Delgado‐Baquerizo; Jieying Wang; Xinyi Zhang; Yiqi Luo; Timothy J. Griffis; Xinhui Han; Gehong Wei; Jun Wang; et al. (Global Ecology and Biogeography, 2022)
Aim Fresh carbon (C) inputs to the soil can have important consequences for the decomposition rates of soil organic matter (priming effect), thereby impacting the delicate global C balance at the soil–atmosphere interface. Yet, the environmental factors that control soil priming effect intensity remain poorly understood at a global scale. Location Global. Time period 1980–2020. Major taxa studied Soil priming effect intensity. Methods We conducted a global dataset of CO 2 effluxes in 711 pairwise soils with 13 C or 14 C simple C sources inputs and without C inputs from incubation experiments in which isotope‐labelled C was used to quantify fresh C‐induced rather than exudate‐induced priming. Results Soil priming effect intensity is predominantly positive. Soil texture and C content were identified as the most important factors associated with priming effects, with sandy soils from tropical and mid‐latitudes supporting the highest soil priming effect intensity, and soils with greater C content and fine textures from high latitudes maintaining the lowest soil priming effects. The negative association between C content and soil priming effect intensity was also indirectly driven by changing mean annual temperature, net primary productivity, and fungi : bacteria ratio. Using this information, we generated a global map of soil priming effect intensity, and found that the priming was lower at high latitudes and higher at lower latitudes. Main conclusions Global patterns of soil priming effect intensity can be predicted using environmental data, with soil texture and C content playing a predominant role in explaining in priming effects. These effects were also indirectly driven by climate, vegetation and soil microbial properties. We present the first global atlas of soil priming effect intensity and advance our knowledge on the potential mechanisms underlying soil priming effect intensity, which are integral to improving the climate change and soil C dynamics components of Earth System models.

A neuropsin-based optogenetic tool for precise control of Gq signaling - Ruicheng Dai; Tao Yu; Danwei Weng; Heng Li; Yuting Cui; Zhaofa Wu; Qingchun Guo; Haiyue Zou; Wenting Wu; Xinwei Gao; Zhongyang Qi; Yuqi Ren; et al. (Science China Life Sciences, 2022)

Cis-element amplified polymorphism (CEAP), a novel promoter- and gene-targeted molecular marker of plants - Meiyan Chen; Xinhua He; Xing Huang; Tingting Lu; Yili Zhang; Jiawei Zhu; Haixia Yu; Cong Luo (Physiology and Molecular Biology of Plants, 2022)

Quantitative back analysis of in situ tests on guiding flexible barriers for rockfall protection based on 4D energy dissipation - Liru Luo; Zhixiang Yu; Yuntao Jin; Lijun Zhang; Liping Guo; Xin Qi; Shichun Zhao (Landslides, 2022)

Increases in temperature response to CO2 emissions in biochar-amended vegetable field soil - Rong Huang; Zifang Wang; Yi Xiao; Luo Yu; Xuesong Gao; Changquan Wang; Bing Li; Qi Tao; Qiang Xu; Ming Gao (Environmental Science and Pollution Research, 2022)

Transformation of HBCDs by Rhodococcus sp. stu-38 - Fei Yu; Wenqi Luo; Yuyang Li; Shanshan Meng; Xianbin Lin; Lele Li; Xueying Ye; Hui Wang; Tao Peng; Tongwang Huang; Zhong Hu (Current Microbiology, 2022)

Biochar accelerates soil organic carbon mineralization via rhizodeposit-activated Actinobacteria - Yingyi Fu; Yu Luo; Muhammad Auwal; Bhupinder Pal Singh; Lukas Van Zwieten; Jianming Xu (Biology and Fertility of Soils, 2022)

Description of Prasinibacter corallicola gen. nov., sp. nov., a zeaxanthin-producing bacterium isolated from stony coral Porites lutea - Guanghua Wang; Jianfeng Liu; Yuanjin Li; Jin Li; Jixin Luo; Biao Chen; Zhiheng Liao; Hongfei Su; Jiayuan Liang; Kefu Yu (Antonie van Leeuwenhoek, 2022)

Rhodoflexus caldus gen. nov., sp. nov., a new member of the phylum Bacteroidota isolated from a hot spring sediment - Ze-Tao Liu; Lan Liu; Wen-Dong Xian; Zheng-Han Lian; Jun-Yi Dai; Bao-Zhu Fang; Meng-Meng Li; Ai-Ping Lv; Zhen-Hao Luo; Jian-Yu Jiao; Wen-Jun Li (Antonie van Leeuwenhoek, 2022)

Gelatin From Cartilage of Siberian Sturgeon (Acipenser baerii): Preparation, Characterization, and Protective Function on Ultraviolet-A-Injured Human Skin Fibroblasts - Zhe Zhang; Yu-Mei Wang; Yi-Ting Qiu; Chang-Feng Chi; Hong-Yu Luo; Bin Wang (Frontiers in Marine Science, 2022)
For full use of the by-products during Siberian sturgeon ( Acipenser baerii ) processing, gelatin was extracted from the cartilages using the hot water method, and its physico-chemical properties and protective function on ultraviolet-A injured human skin fibroblasts (HFSBs) were measured. Using single-factor and orthogonal experiments, the conditions for extracting gelatin from Siberian sturgeon cartilage were optimized as extraction time of 7 h, pH 9, material-to-liquid ratio (g/ml) of 1:5, and temperature of 45°C. The prepared gelatin (TCG) with a yield of 28.8 ± 1.53% had Gly (307 residues/1,000 residues) as the major amino acid and contained a lower amount (214 residues/1,000 residues) of imino acids than that (227 residues/1,000 residues) of pigskin gelatin (PSG). Sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE), ultraviolet spectrum, and infrared spectroscopy analysis indicated that TCG had the main spectral characteristics of fish gelatin and contained α chains (α1 and α2 chains) and β chain of type I collagen, but its structural stability was lower than that of PSG due to its low content of imino acids, which induced the smaller molecular bands observed in the SDS-PAGE pattern. TCG exhibited lower water content, gel strength, emulsion stability index, foam capacity, foam stability, and water-holding capacity but higher ash content, transmittance, emulsion activity index, and fat-binding capacity ( P < 0.05). Moreover, TCG could significantly protect HFSBs against ultraviolet-A injury by enhancing the activity of superoxide dismutase, catalase, and glutathione peroxidase to scavenge excess reactive oxygen species and decrease the content of malondialdehyde. Therefore, gelatin from Siberian sturgeon cartilages could act as promising candidates when applied in health-promoting products against ultraviolet-A injury.

Comparative Transcriptome Analysis Reveals the Adaptation Mechanism to High Salinity in Litopenaeus vannamei - Zheng Luo; Yang Yu; Qian Zhang; Zhenning Bao; Jianhai Xiang; Fuhua Li (Frontiers in Marine Science, 2022)
As an euryhaline commercial species, the Pacific white shrimp Litopenaeus vannamei can be cultured under a wide range of salinities. However, different families showed various tolerance to high salinity. In order to elucidate the underlying mechanisms, a comparative transcriptome approach was used to find the differences between tolerant families and susceptible families at the transcriptional level. There were 98 and 58 differentially expressed genes (DEGs) between tolerant and susceptible families under normal and high-salinity conditions, respectively. The DEGs upregulated in tolerant families were mostly enriched in the biological process of response to a stimulus. Nine crustacyanin (CRCN)-encoding genes in this Gene Ontology (GO) term showed significantly higher expression levels in the tolerant families than those in susceptible families, suggesting that crustacyanins might play important roles in shrimp tolerance to high salinity. After high-salinity treatment, a total of 233 and 109 DEGs were identified from tolerant and susceptible families, respectively. Serine-type endopeptidase activity, serine-type peptidase activity, and serine hydrolase activity were the top three GO terms in the tolerant families after high-salinity treatment. Further analysis illustrated that these three GO terms were also the top three enriched GO terms for the DEGs specifically upregulated in the tolerant families after high-salinity stress. Meanwhile, four genes annotated in serine proteases families in these three GO terms were upregulated in the tolerant families but not changed in the susceptible families after high-salinity stress. These results indicated that serine proteases should play key roles in shrimp tolerance to high salinity. This study provides important information for understanding the mechanism of shrimp tolerance to high-salinity stress and would be useful for further molecular breeding of shrimp varieties with high-salinity tolerance.

A Brief Overview of Global Trends in MSC-Based Cell Therapy - Dragomirka Jovic; Yingjia Yu; Dan Wang; Kuixing Wang; Hanbo Li; Fengping Xu; Chenglong Liu; Junnian Liu; Yonglun Luo (Stem Cell Reviews and Reports, 2022)

Mechanical Properties and Deterioration Mechanism of Remolded Carbonaceous Mudstone Exposed to Wetting–Drying Cycles - Yu-Ling Yang; Tao Zhang; Song-Yu Liu; Jun-Hui Luo (Rock Mechanics and Rock Engineering, 2022)

Prediction of drought/flood intensities based on a 500-year time series in three different climate provinces of China - Yu Peng; Zhaohua Wang; Yixin Cui; Yali Su; Yiyun Tang; Shiqian Luo; Lianlin Liu; Yanqiu Zhou; Jihui Dong; Wentao Wang; Xiang Li; Jiaxin Shang; et al. (Regional Environmental Change, 2022)

A Deep Mesencephalic Nucleus Circuit Regulates Licking Behavior - Di Zheng; Jia-Yu Fu; Meng-Yu Tang; Xiao-Dan Yu; Yi Zhu; Chen-Jie Shen; Chun-Yue Li; Shi-Ze Xie; Shan Lin; Minmin Luo; Xiao-Ming Li (Neuroscience Bulletin, 2022)

lncRNA BDNF-AS Attenuates Propofol-Induced Apoptosis in HT22 Cells by Modulating the BDNF/TrkB Pathway - Yu-Hai Xu; Yuan Luo; Jiang-Bei Cao; Yan-Hong Liu; Yu-Xiang Song; Xiao-Ying Zhang; Qiang Fu; Wei-Dong Mi; Hao Li (Molecular Neurobiology, 2022)
Propofol is widely used as an intravenous anesthetic in clinical practice. Previous studies have indicated that propofol induces apoptosis in neurons. Brain-derived neurotrophic factor (BDNF), a neurotrophic factor, is associated with neuronal apoptosis. BDNF-AS, a relatively conserved long non-coding RNA, can reverse the transcription of BDNF. This study aimed to investigate the involvement of BDNF-AS in propofol-induced apoptosis in HT22 cells. HT22 cells were treated with various concentrations of propofol at different time points. BDNF-AS was silenced using BDNF-AS-targeting siRNA. TrkB was antagonized by the TrkB inhibitor, ANA-12. Flow cytometry, quantitative reverse-transcription PCR, and western blotting were performed to analyze apoptosis and the expression of genes and proteins, respectively. In propofol-treated HT22 cells, BDNF-AS was upregulated, and BDNF was downregulated in a time- and dose-dependent manner. BDNF-AS downregulation mediated by siRNA mitigated apoptosis, upregulated the expression of Bcl-2, and downregulated the expression of Bax and caspase-3, 7, and 9. ANA-12 downregulated the expression of Bcl-2, upregulated the expression of Bax and caspase-3, 7, and 9, and increased apoptosis. Our study implied that inhibition of BDNF-AS can decrease propofol-induced apoptosis by activating the BDNF/TrkB pathway. Thus, the BDNF-AS-BDNF/TrkB signaling pathway may be a valuable target for treating propofol-induced neurotoxicity.

Association between MAP3K4 gene polymorphisms and the risk of schizophrenia susceptibility in a Northeast Chinese Han population - Yang Sun; Ye Lv; Hui-Wen Ren; Guan-Yu Wang; Li-Na Xuan; Yi-Yang Luo; Zhi-Lin Luan (Metabolic Brain Disease, 2022)

Ligustilide ameliorates cognitive impairment via AMPK/SIRT1 pathway in vascular dementia rat - Dong Peng; Han-Zi Qiao; Hong-Yu Tan; Yi-Xue Wang; Dan Luo; Li-Jun Qiao; Ye-Feng Cai; Shi-Jie Zhang; Qi Wang; Li Guan (Metabolic Brain Disease, 2022)

CircRFX3 Up-regulates Its Host Gene RFX3 to Facilitate Tumorigenesis and Progression of Glioma - Yu Qian; Baochun Cheng; Jing Luo; Yangchun Hu; Lu Gao; Hongwei Cheng (Journal of Molecular Neuroscience, 2022)

CNNLSTMac4CPred: A Hybrid Model for N4-Acetylcytidine Prediction - Guiyang Zhang; Wei Luo; Jianyi Lyu; Zu-Guo Yu; Guohua Huang (Interdisciplinary Sciences: Computational Life Sciences, 2022)

Stabilization and remediation of heavy metal-contaminated soils in China: insights from a decade-long national survey - Yan Ma; Lina Wang; Yunzhe Cao; Tian Liang; Panpan Wang; Huilong Luo; JingJing Yu; Dading Zhang; Baoshan Xing; Bin Yang (Environmental Science and Pollution Research, 2022)

A critical review on EDTA washing in soil remediation for potentially toxic elements (PTEs) pollutants - Yaoning Chen; Hongjuan Jiang; Yuanping Li; Yihuan Liu; Yanrong Chen; Li Chen; Xinli Luo; Ping Tang; Haoqin Yan; Mengyang Zhao; Yu Yuan; Suzhen Hou (Reviews in Environmental Science and Bio/Technology, 2022)

Effects of acid deposition on the avoidance behavior of Folsomia candida (Collembola, Isotomidae) - Xiaofeng Luo; Linglong Zhu; Guoliang Xu; Jiaen Zhang; Jianlong Xu; Shiqin Yu; Xiaohua Chen (Soil Ecology Letters, 2022)

Alternate freezing and thawing enhanced the sediment and nutrient runoff loss in the restored soil of the alpine mining area - Fa-Yong Li; Ren-jie Luo; Yong-jun You; Xue-fei Hu; Xiao-yan Qian; Peng-yan Zhang; Shan Wang; Guo-yu Li; Mohamed Eltohamy Kamel (Journal of Mountain Science, 2022)

Ambra1 regulates apoptosis and chemosensitivity in breast cancer cells through the Akt-FoxO1-Bim pathway - Wei-liang Sun; Ling-yan He; Li Liang; Si-yu Liu; Jie Luo; Mei-ling Lv; Zheng-wen Cai (Apoptosis, 2022)

Distinct Evolution of the SST Anomalies in the Far Eastern Pacific between the 1997/98 and 2015/16 Extreme El Niños - Shaolei Tang; Jing-Jia Luo; Lin Chen; Yongqiang Yu (Advances in Atmospheric Sciences, 2022)

Differences in Fatty Acids and Lipids of Massive and Branching Reef-Building Corals and Response to Environmental Changes - Chengyue Liu; Yuyang Zhang; Lintao Huang; Xiaolei Yu; Yong Luo; Lei Jiang; Youfang Sun; Sheng Liu; Hui Huang (Frontiers in Marine Science, 2022)
Reef-building corals present various colony morphologies that may greatly influence their nutritional ecology. Fatty acids (FAs) and lipids are important components of corals and have been increasingly used to research the nutritional ecology of corals. In this study, we examined the symbiodiniaceae density, corallite area, total lipid content, and FAs composition of 14 species of corals with different colony morphologies. The results showed that the different colony morphology of coral was significantly correlated with the corallite area but not with the symbiodiniaceae density. Massive corals, with a large corallite area (7.16 ± 6.29 mm 2 ), could ingest a high quantity of food, leading to high levels of total lipid content and unsaturated FAs [particularly n-6 polyunsaturated FAs (PUFAs) and monounsaturated FAs]. For branching corals, the total lipid content and saturated FAs (SFAs, 16:0 and 18:0) were significantly positively correlated with the Symbiodiniaceae density, indicating that branching corals are predominantly autotrophic. Moreover, compared with healthy corals, bleached corals consume larger amounts of stored energy (such as lipids and SFAs) to maintain their normal physiological functions. Although bleached corals may obtain PUFAs from heterotrophic assimilation or biosynthesize, the efficiency is too low to sufficiently replenish essential PUFAs in a short time. Overall, massive corals with more initial total lipid content and PUFAs exhibit an advantage under adverse environmental conditions.

How do precipitation events modify the stable isotope ratios in leaf water at Lhasa on the southern Tibetan Plateau? - Yong Wang; Wusheng Yu; Lun Luo; Minghui Li; Xiaoming Liu; Rong Guo; Yaoming Ma; Baiqing Xu; Guangjan Wu; Chengyi Zhao; Zhaowei Jing; Feili Wei; et al. (Isotopes in Environmental and Health Studies, 2022)

Reconstruction of chlorophyll-a satellite data in Bohai and Yellow sea based on DINCAE method - Xiaomin Luo; Jun Song; Junru Guo; Yanzhao Fu; Linhui Wang; Yu Cai (International Journal of Remote Sensing, 2022)

Toxicity analysis of TNT to alfalfa's mineral nutrition and secondary metabolism - Xu Yang; Jin-long Lai; Yu Zhang; Xue-gang Luo (Plant Cell Reports, 2022)

Mechanisms of Repetitive Transcranial Magnetic Stimulation on Post-stroke Depression: A Resting-State Functional Magnetic Resonance Imaging Study - Yamei Li; Kuide Li; Rongjian Feng; Yi Li; Yufeng Li; Hong Luo; Qian Yu (Brain Topography, 2022)

Short-term variations and influencing factors of suspended sediment concentrations at the Heisha Beach, Guangdong, China - Jintang Ou; Haoyan Dong; Liangwen Jia; Xiangxin Luo; Zixiao He; Kanglin Chen; Jing Liu; Yitong Lin; Mingdong Yu; Mingen Liang (Acta Oceanologica Sinica, 2022)

Spinocerebellar Ataxia Type 10 with Atypical Clinical Manifestation in Han Chinese - Chengyuan Mao; Xinwei Li; Yun Su; Haiyang Luo; Liyuan Fan; Huimin Zheng; Yu Fan; Zhihua Yang; Shuo Zhang; Zhengwei Hu; Xiaoyan Hao; Changhe Shi; et al. (The Cerebellum, 2022)

Chromosome-Scale Assembly and Characterization of the Albino Northern Snakehead, Channa argus var. (Teleostei: Channidae) Genome - Chaowei Zhou; Yan Li; Yan Zhou; Yu Zou; Dengyue Yuan; Xingxing Deng; Luo Lei; Jian Su; Chengke Zhu; Hua Ye; Hui Luo; Guangjun Lv; et al. (Frontiers in Marine Science, 2022)
Northern snakehead, Channa argus ( C. argus ), is an important economic and ecological fish species. The wild population of the species was sharply declined in the last decade. A high-quality reference genome could lay a solid foundation for the genetic and conservation studies for C. argus . In this work, we report a chromosomal genome assembly with PacBio and Hi-C technology using the albino northern snakehead, a color variety of C. argus . A 644.1-Mb genome with 24 chromosomes was obtained with a contig and scaffold N50 of 11.78 and 27.8 Mb, respectively. We inferred that C. argus diverged from A. testudineus around 85.6 million years ago. 514 expanded gene families and 214 positively selected genes were identified in the C. argus genome. The chromosome-level genome provides a valuable high-quality genomic resource for population, as well as genetic and evolutionary studies for C. argus and other species in Channidae.

Contrasting responses of plant above and belowground biomass carbon pools to extreme drought in six grasslands spanning an aridity gradient - Md. Shahariar Jaman; Honghui Wu; Qiang Yu; Qiqi Tan; Yunlong Zhang; Quoc Khanh Dam; Taofeek O. Muraina; Chong Xu; Minghui Jing; Xiaotong Jia; Jie Wang; Nianpeng He; et al. (Plant and Soil, 2022)

Resistance of steppe communities to extreme drought in northeast China - Wang Ma; Xiaosa Liang; Zhengwen Wang; Wentao Luo; Qiang Yu; Xingguo Han (Plant and Soil, 2022)

Chronic and intense droughts differentially influence grassland carbon-nutrient dynamics along a natural aridity gradient - Wentao Luo; Xiaoan Zuo; Robert J. Griffin-Nolan; Chong Xu; Jordi Sardans; Qiang Yu; Zhengwen Wang; Xingguo Han; Josep Peñuelas (Plant and Soil, 2022)

PlantRep: a database of plant repetitive elements - Xizhi Luo; Shiyu Chen; Yu Zhang (Plant Cell Reports, 2022)
Key message We re-annotated repeats of 459 plant genomes and released a new database: PlantRep ( http://www.plantrep.cn/ ). PlantRep sheds lights of repeat evolution and provides fundamental data for deep exploration of genome.

Soil sterilization and fertility impacts on urease and belowground mass specific phosphatase activity vary among Chinese tallow tree (Triadica sebifera) populations - Nasir Shad; Qian Liu; Haifu Fang; Baihui Wang; Yu Gao; Xiaojun Liu; Laicong Luo; Wenyuan Zhang; Evan Siemann; Ling Zhang (Plant Ecology, 2022)

MiR-556-5p modulates migration, invasion, and epithelial-mesenchymal transition in breast cancer cells via targeting PTHrP - Rongjun Zhou; Zhen Luo; Guanqun Yin; Lanting Yu; Hao Zhong (Journal of Molecular Histology, 2022)

The role and mechanism of abscisic acid in mitigating the adverse impacts of high temperature in Gracilariopsis lemaneiformis - Peng Sun; Qionglin Chen; Suya Luo; Xinlei Yu; Xiaoqian Zhang; Nianjun Xu; Xue Sun (Journal of Applied Phycology, 2022)

Localization of QTL for cold tolerance at the germination stage of rice (Oryza sativa L.) using recombinant inbred lines - Liangzi Cao; Shukun Jiang; Guohua Ding; Tongtong Wang; Liangming Bai; Jinsong Zhou; Yu Luo; Tianshu Xia; Hui Jiang; Kai Liu; Xueyang Wang; Guang Yang; et al. (Genetic Resources and Crop Evolution, 2022)
The cold tolerance of germinating direct-sown rice ( Oryza sativa L.) has an increased rate of emergence, which ensures vigorous seedling growth. Research on QTL localization for cold tolerance at the germination stage can assist in molecular marker-assisted selection and enhance breeding efficiency. In this study, 94 populations of recombinant self-incompatible lines from Heigu and Ha 9366 were selected to investigate germination rates at low temperatures. It was found that two QTL loci (qLTG-3 and qLTG-12) were located at different germination times on chromosomes 3 and 12, respectively. The two QTLs at three different germination times, located using QTL, accounted for 21.3–25.9% of the phenotypic variation. Moreover, a reciprocal effect was detected between the two QTLs. The double QTLs increased the germination rate by 22–27% in this population. Additionally, qLTG-12 improved cold tolerance at the seedling stage. The results of this study might provide the materials and molecular markers for future molecular marker-assisted breeding for cold tolerance at the germination stage.

Novel bioavailability-based risk assessment of Cd in earthworms and leeches utilizing in vitro digestion/Caco-2 and MDCK cells - Tian-tian Zuo; Fei-ya Luo; Huai-zhen He; Hong-yu Jin; Lei Sun; Shu-xia Xing; Bo Li; Fei Gao; Shuang-cheng Ma; Lang-chong He (Environmental Science and Pollution Research, 2022)

Deep Learning for Seasonal Precipitation Prediction over China - Weixin Jin; Yong Luo; Tongwen Wu; Xiaomeng Huang; Wei Xue; Chaoqing Yu (Journal of Meteorological Research, 2022)

Magnesium Isotopes in Pore Water of Active Methane Seeps of the South China Sea - Meng Jin; Dong Feng; Kangjun Huang; Shanggui Gong; Min Luo; Jörn Peckmann; Xudong Wang; Yu Hu; Duofu Chen (Frontiers in Marine Science, 2022)
The magnesium (Mg) isotopic composition of marine authigenic carbonates is considered as promising archive of ancient seawater geochemistry and paleoenvironments. Previous experimental and theoretical work has shown that Mg isotope fractionation during carbonate mineral formation is a function of mineralogy and precipitation rate. However, information on Mg isotope fractionation is limited for well-defined precipitation rates in natural settings. Here, we investigate pore waters from sediments of an area of active methane seepage in the South China Sea. Low δ 13 C values (< −48.3‰ VPDB) of dissolved inorganic carbon (DIC) near the sulfate-methane transition zone (SMTZ) indicate that sulfate-driven anaerobic oxidation of methane (SD-AOM) is the predominant biogeochemical process. Pore water composition of dissolved Mg, calcium (Ca), and strontium (Sr) agrees with aragonite as the dominant carbonate mineral at the site ROV1, and high Mg-calcite at sites ROV2 and ROV4. Calculated carbonate precipitation rates are 0.92 μmol cm −2 yr −1 for site ROV2 and 1.24 μmol cm −2 yr −1 for site ROV4; these estimates are similar to previous calculations for seeps from other areas. The pore water δ 26 Mg values (−0.88‰ to −0.71‰) obtained for the three study sites are similar to those of seawater, in accord with a minor effect of Rayleigh fractionation due to abundant supply of Mg from seawater and insignificant consumption of Mg during carbonate precipitation. The modeled Mg isotope fractionation (ϵ = −2.0‰ to −1.0‰ for core ROV2; ϵ = −1.3‰ to −0.3‰ for core ROV4) can be explained by kinetic isotope fractionation during carbonate precipitation. The calculated carbonate precipitation rates and the degree of fractionation of Mg isotopes support the notion that fractionation is small at high precipitation rates. However, the carbonate precipitation rates calculated for the studied seep environments are much smaller than those in laboratory experiments, documenting a discrepancy of isotopic fractionation between carbonate authigenesis in laboratory experiments and natural environments. These results, including the modeled precipitation rates, provide new constraints for Mg isotope fractionation in natural settings.

Environmental Regulation of Photosynthetically Produced Dissolved Organic Carbon by Phytoplankton Along a Subtropical Estuarine Bay - Jianhua Kang; Zhaohe Luo; Hala. F. Mohamed; Yili Lin; Shuhong Huang; Yu Wang; Wenlu Lan (Frontiers in Marine Science, 2022)
Photosynthetically produced dissolved organic carbon (PDOC) released by marine phytoplankton has an important significance on the marine carbon cycle and on the growth of heterotopic bacteria (HB). However, PDOC is often neglected in the estimation of global marine primary productivity and carbon sequestration capacity. This work studied the issue of PDOC and its environmental regulation mechanism through field investigation and lab experiments in an estuarine bay during southwest and northeast monsoon. We used the percentage of extracellular release (PER) as a key indicator to evaluate the contribution of PDOC to total primary productivity (TPP). We also compared PER among different seasons and sectors and then analyzed the inter-relationship between PDOC and bacterial carbon demand (BCD), size-fractionated phytoplankton, bacterial production (BP), and TPP. We finally discussed the impact factors of PDOC productivity. The results showed that the average contribution of PDOC to TPP in Qinzhou bay could reach 15% during two seasons, which satisfies about 25% of the carbon requirement by HB in the bay. Multiple factors contribute to the seasonal (SW monsoon 13% < NE monsoon 18%) and sectoral variation (outer bay 26% > middle bay 17% > inner bay 7%) in PER, the most significant of which are salinity and nitrogen to phosphorus ratios. PER is also related to phytoplankton community structure and nutrient limitation, the higher PER in the outer bay is attributed to the dual effect of picophytoplankton being the predominant species and a severe imbalance in the nitrogen to phosphorus ratio, both of which lead to increased phytoplankton PDOC release. On the other hand, the lower PER in the inner bay was mainly due to the dominance of microphytoplankton and nitrogen to phosphorus ratio which is close to the redfield ratio. There is still a non-uniform conclusion on the relationship between PER and TPP, suggesting that this relationship needs to be evaluated not only in a horizontal-independent way but also through seasonal and vertical dimensions. The non-linear relationship between PDOC and BCD found in this study potentially indicated weak coupling between phytoplankton exudation and bacterial metabolism. In addition to phytoplankton exudate, HB is still dependent on other sources of DOC to meet their carbon requirements.

Legacy effects of a multi-year extreme drought on belowground bud banks in rhizomatous vs bunchgrass-dominated grasslands - Jianqiang Qian; Ziyue Guo; Taofeek O. Muraina; Niwu Te; Robert J. Griffin-Nolan; Lin Song; Chong Xu; Qiang Yu; Zhiming Zhang; Wentao Luo (Oecologia, 2022)

QTL mapping integrated with BSA-Seq analysis identifies a novel gene conferring resistance to brown planthopper from common wild rice (Oryza rufipogon Griff.) - Xuan Wang; Yue Han; Yue-xiong Zhang; Biao Deng; Bi-qiu Wu; Xin-ying Guo; Yu-fen Qin; Yao-yu Fang; Fang Liu; Bao-xiang Qin; Ji-jing Luo; Rong-bai Li (Euphytica, 2022)

Local adaptation and migratory habits balance spatial‐genetic structure between continental and insular chestnut tiger butterflies in East Asia - Min‐Xin Luo; Hsin‐Pei Lu; Bing‐Hong Huang; Chia‐Lung Huang; Yu‐Feng Hsu; Pei‐Chun Liao (Molecular Ecology, 2022)
Geographic and climatic differences between islands and continents may affect the evolution of their biota, and promote divergent selection in species distributed in both landscapes. To assess spatial‐genetic structure, we genotyped 18 expressed sequence tag‐simple sequence repeat (EST‐SSR) loci and sequenced two mtDNA markers ( ND5 and COI ) and one nuclear marker ( EF1α ) in two subspecies of the butterfly Parantica sita . Compared with nuclear markers, mtDNA had a stronger signal of population structure. Approximate Bayesian computation (ABC) suggested that a continuous‐gene‐flow model best described the data. According to this model, the two subspecies diverged approximately 23.1 kya, with 10 times more introgression from the continental (ssp. sita ) to the insular subspecies (ssp. niphonica ) than vice versa. Ecological niche modelling was performed to predict the paleo‐ and current potential distributions and elucidate the geohistorical process, which revealed a northeastern, insular origin. Winter precipitation and annual temperature range were the main determinants of the subspecies distributions. Maximum‐likelihood population‐effects models showed that the population differentiation of the insular and continental subspecies was primarily affected by environmental resistance and local climate. Sex‐biased migration capacity and long‐term precipitation‐driven divergence between the continental and insular lineages shaped the current genetic structure of P . sita . Evidence from the nuclear markers confirmed intersubspecific gene flow despite adaptive divergence between the subspecies. These results imply that the continental subspecies is still capable of returning to the island and introgressing with the insular subspecies.

Genetic Diversity and Structure of Tropical Porites lutea Populations Highlight Their High Adaptive Potential to Environmental Changes in the South China Sea - Yanqiu Luo; Wen Huang; Kefu Yu; Ming Li; Biao Chen; Xueyong Huang; Zhenjun Qin (Frontiers in Marine Science, 2022)
Global climate change and anthropogenic disturbance have significantly degraded biodiversity in coral reef ecosystems. The genetic potential and adaptability of corals are key factors used to predict the fate of global coral reefs under climate change. In this study, we used eight microsatellite loci to study the patterns of reproduction, genetic diversity, and genetic structure of 302 Porites lutea samples across 13° latitudes in the South China Sea (8.8644°N–22.6117°N). The results indicated that P. lutea reproduces largely via sexual reproduction on scales of 5 m and greater and has abundant gene diversity. Additionally, the tropical populations harbored high genetic diversity (based on alleles, effective number of alleles, gene diversity, and heterozygosity). In contrast, genetic diversity was lower in subtropical coral populations. Genetic variation values and pairwise F ST revealed that tropical and subtropical populations had significantly different genetic structures. Finally, the Mantel tests showed that the genetic differentiation and genetic variation of P. lutea were strongly correlated with sea surface temperature and slightly correlated with geographical distance. These results indicated that tropical P. lutea populations have high genetic potential and adaptability because of their sexual reproduction and genetic diversity, giving them a greater capacity to cope with climate change. Subtropical coral populations showed lower genetic diversity and, thus, relatively poor genetic resilience in response to low average sea surface temperature and human activities. Our study provides a theoretical basis for the protection and restoration of coral reefs.

Sweet tea ( Lithocarpus polystachyus rehd.) as a new natural source of bioactive dihydrochalcones with multiple health benefits - Ao Shang; Hong-Yan Liu; Min Luo; Yu Xia; Xiao Yang; Hang-Yu Li; Ding-Tao Wu; Quancai Sun; Fang Geng; Ren-You Gan (Critical Reviews in Food Science and Nutrition, 2022)

White Matter Free Water is a Composite Marker of Cerebral Small Vessel Degeneration - Peiyu Huang; Ruiting Zhang; Yeerfan Jiaerken; Shuyue Wang; Hui Hong; Wenke Yu; Chunfeng Lian; Kaicheng Li; Qingze Zeng; Xiao Luo; Xinfeng Yu; Xiao Wu; et al. (Translational Stroke Research, 2022)

Ubiquitylomes and proteomes analyses provide a new interpretation of the molecular mechanisms of rice leaf senescence - Xiangzhen Yu; Yongsheng Zhu; Yunjie Xie; Lele Li; Ziyi Jin; Yunrui Shi; Cuiqin Luo; Yidong Wei; Qiuhua Cai; Wei He; Yanmei Zheng; Huaan Xie; et al. (Planta, 2022)

Digoxin Ameliorates Glymphatic Transport and Cognitive Impairment in a Mouse Model of Chronic Cerebral Hypoperfusion - Jie Cao; Di Yao; Rong Li; Xuequn Guo; Jiahuan Hao; Minjie Xie; Jia Li; Dengji Pan; Xiang Luo; Zhiyuan Yu; Minghuan Wang; Wei Wang (Neuroscience Bulletin, 2022)

A Neural Circuit Mechanism Controlling Breathing by Leptin in the Nucleus Tractus Solitarii - Hongxiao Yu; Luo Shi; Jinting Chen; Shirui Jun; Yinchao Hao; Shuang Wang; Congrui Fu; Xiang Zhang; Haiyan Lu; Sheng Wang; Fang Yuan (Neuroscience Bulletin, 2022)

The effects and possible mechanism of action of apolipoprotein M on the growth of breast cancer cells - Ying Zhou; Shuang Yao; Miaomei Yu; Jiang Wei; Qi Fang; Ning Xu; Guanghua Luo (Molecular Biology Reports, 2022)

Consistent responses of microbial C and N metabolic processes to elevated CO2 across global terrestrial ecosystems - Jiahui Lin; Yanlan Huang; Haochun Zhao; Mengjie Yu; Weiqin Su; Huaihai Chen; Peng Leng; Jihui Li; Yu Luo; Yong Li; Zhongmin Dai; Jianming Xu (Journal of Soils and Sediments, 2022)

Evaluating the impact of roads on the diversity pattern and density of trees to improve the conservation of species - Uzair Aslam Bhatti; Zhaoyuan Yu; Ahmad Hasnain; Saqib Ali Nawaz; Linwang Yuan; Luo Wen; Mughair Aslam Bhatti (Environmental Science and Pollution Research, 2022)

Comparative analysis of daily and hourly temperature variability in association with all-cause and cardiorespiratory mortality in 45 US cities - Yong Yu; Siqi Luo; Yunquan Zhang; Linjiong Liu; Ke Wang; Le Hong; Qun Wang (Environmental Science and Pollution Research, 2022)

Evidence for the involvement of Fe(IV) in water treatment by Fe(III)-activated sulfite - Luna Luo; Zhen Wang; Qin Guo; Xipeng Wei; Jianpeng Hu; Yu Luo; Jin Jiang (Environmental Chemistry Letters, 2022)

Genetic diversity of natural populations of Taxus mairei - Qianqian Luo; Fengqing Li; Longhua Yu; Liyun Wang; Gangbiao Xu; Zhichun Zhou (Conservation Genetics, 2022)

Microstructural white matter alterations in Alzheimer’s disease and amnestic mild cognitive impairment and its diagnostic value based on diffusion kurtosis imaging: a tract-based spatial statistics study - Tongtong Li; Yu Zhang; Xiuwei Fu; Xianchang Zhang; Yuan Luo; Hongyan Ni (Brain Imaging and Behavior, 2022)

The synergistic benefits of β-aminobutyric acid and γ-aminobutyrate on salt and drought tolerance in cassava - Xiaowen Ma; Jinbao Gu; Qingwen Luo; Mingfu Wen; Hua Li; Zhen-Yu Wang (Plant Biotechnology Reports, 2022)

Identifying the priority areas for enhancing the ecosystem services in hilly and mountainous areas of southern China - Jia-ling Tian; Yu Peng; Yi-hang Huang; Ting Bai; Lian-lin Liu; Xiao-ao He; Shi-qian Luo (Journal of Mountain Science, 2022)

Fluctuations in the heart rate of abalone in response to low salinity stress - Grace Afumwaa Boamah; Feng Yu; Yawei Shen; Weiwei You; Changan Xu; Xuan Luo; Caihuan Ke (Aquaculture International, 2022)

Characterization of PGRP-LB and immune deficiency in the white-backed planthopper Sogatella furcifera (Hemiptera: Delphacidae) - Yaya Yu; Chunli Luo; Daowei Zhang; Jing Chen (Applied Entomology and Zoology, 2022)
Peptidoglycan recognition proteins (PGRPs) participate in insect defense against bacterial pathogens by recognizing bacterial cell wall peptidoglycans (PGNs). Here, we identified the PGRP-LB gene in the white-backed planthopper Sogatella furcifera ( SfPGRP-LB ). SfPGRP-LB is a secreted protein with a typical PGN-binding domain and five conserved amino acid (aa) residues required for amidase activity. Expression analysis showed that the SfPGRP-LB transcript levels were significantly higher in the midgut than in other tissues. Silencing SfPGRP-LB with dsRNA significantly downregulated the expression of Toll pathway genes Toll and Dorsal and Imd pathway genes Imd and Relish after Escherichia coli challenge. However, only Toll and Dorsal expressions were downregulated after Staphylococcus aureus challenge. E. coli and S. aureus challenges rapidly and strongly upregulated SfPGRP-LB expression. Recombinantly expressed SfPGRP-LB (rSfPGRP-LB) had strong affinities for E. coli Dap-type PGN and S. aureus Lys-type PGN and agglutinated the bacteria. However, rSfPGRP-LB inhibited S. aureus but not E. coli growth. Furthermore, rSfPGRP-LB had amidase activity, degraded Lys-type PGN, and destroyed S. aureus cell walls but had no such effects on E. coli Dap-type PGN. Thus, SfPGRP-LB recognizes and binds various bacterial PGNs but only has amidase activity against Lys-type PGN.

Evidence for niche conservatism in alpine beetles under a climate‐driven species pump model - Jillian Schat; Yi‐Ming Weng; Roman Yu. Dudko; David H. Kavanaugh; Lan Luo; Sean D. Schoville (Journal of Biogeography, 2022)
Aim Past glacial cycles have generated lineage diversity in alpine habitats, acting as a climate‐driven species pump. It is not clear how much this process contributes to ecological diversification of alpine species. To examine this problem, we test patterns of genetic and phenotypic divergence in two co‐distributed species complexes of flightless alpine ground beetles. Greater differentiation in functional traits would indicate that ecological selection is an outcome of oscillating climate change, whereas greater differentiation in non‐ecological traits would indicate niche conservatism. Location The Cascades Range and Trinity Mountains of western North America. Taxon Nebria paradisi and N . vandykei species complexes (Insecta: Coleoptera: Carabidae: Nebriinae). Methods We generated genome‐wide single nucleotide polymorphism data and mitochondrial sequence data, as well as morphological and physiological data, to compare populations spanning the range of both species. Phylogenetic and population genetic analyses were used to infer relationships among taxa and populations in each species complex, as well as historical demography. Support vector machines were used to test for classification of taxa and populations based on ecomorphological, ecophysiological and male reproductive traits. Mantel tests were then used to assess associations between phenotypic and genetic divergence among populations. Results The N . vandykei and N . paradisi species complexes are each comprised of genetically distinctive populations exhibiting long‐term demographic declines. Each phylogeny supports multiple monophyletic groups with geographical cohesion. By examining phenotypic traits among populations in both species’ complexes, we show that reproductive trait divergence can discriminate species and population status more effectively than ecomorphological or ecophysiological traits. Reproductive and genetic divergence are significantly correlated in the N . vandykei species complex. Main Conclusions We found limited evidence of ecological selection acting on functional traits. Instead, reproductive and genetic divergence evolved among isolated populations in both species complexes, suggesting niche conservatism may be a common outcome in alpine species diversification.

A new N -containing phenolic glycoside from Capsicum annuum L. - Changwei Song; Changyan Yu; Xinting Zhu; Xirong Luo; Yong Zhang; Lingjie Meng; Yong Luo; Han Chang; Cheng Qin; Yun Liu (Natural Product Research, 2022)

Environmental Filtering by pH and Salinity Jointly Drives Prokaryotic Community Assembly in Coastal Wetland Sediments - Huang Yu; Qiuping Zhong; Yisheng Peng; Xiafei Zheng; Fanshu Xiao; Bo Wu; Xiaoli Yu; Zhiwen Luo; Longfei Shu; Cheng Wang; Qingyun Yan; Zhili He (Frontiers in Marine Science, 2022)
Understanding the microbial community assembly is an essential topic in microbial ecology. Coastal wetlands are an important blue carbon sink, where microbes play a key role in biogeochemical cycling of nutrients and energy transformation. However, the drivers controlling the distribution patterns and assembly of bacterial and archaeal communities in coastal wetland are unclear. Here we examined the diversity, co-occurrence network, assembly processes and environmental drivers of bacterial and archaeal communities from inshore to offshore sediments by the sequencing of 16S rRNA gene amplicons. The value of α- and β-diversity of bacterial and archaeal communities generally did not change significantly ( P > 0.05) between offshore sites, but changed significantly ( P < 0.05) among inshore sites. Sediment pH and salinity showed significant effects on the diversity and keystone taxa of bacterial and archaeal communities. The bacterial and archaeal co-occurrence networks were inextricably linked with pH and salinity to formed the large network nodes, suggesting that they were the key factors to drive the prokaryotic community. We also identified that heterogeneous and homogeneous selection drove the bacterial and archaeal community assembly, while the two selections became weaker from offshore sites to inshore sites, suggesting that deterministic processes were more important in offshore sites. Overall, these results suggested that the environmental filtering of pH and salinity jointly governed the assembly of prokaryotic community in offshore sediments. This study advances our understanding of microbial community assembly in coastal wetland ecosystems.

Two new nor -lignans from Selaginella pulvinata (Hook. & Grev.) Maxim and their antihyperglycemic activities - Hua-Wei Lv; Yu-Xia Li; Meng Luo; Jia-Meng Qi; Ze-Fei Fu; Hong-Jian Zhang; Yuan-Qiang Guo; Chu Chu; Han-Bing Li; Ji-Zhong Yan (Natural Product Research, 2022)

Glycosidically bound aroma precursors in fruits: A comprehensive review - Zijian Liang; Zhongxiang Fang; Ahalya Pai; Jiaqiang Luo; Renyou Gan; Yu Gao; Jiang Lu; Pangzhen Zhang (Critical Reviews in Food Science and Nutrition, 2022)

Effects of convective available potential energy, temperature and humidity on the variability of thunderstorm frequency over Bangladesh - Md Wahiduzzaman; Md. Arfan Ali; Jing-Jia Luo; Yu Wang; Md. Jalal Uddin; Shamsuddin Shahid; A. R. M. Towfiqul Islam; Sanjit Kumar Mondal; Ubaydur Rahaman Siddiki; Muhammad Bilal; Zhongfeng Qiu; Ramzah Dambul; et al. (Theoretical and Applied Climatology, 2022)

A new analytical mode and application of the laser ablation inductively coupled plasma mass spectrometer in the earth sciences - Yantong Feng; Wen Zhang; Zhaochu Hu; Yongsheng Liu; Tao Luo; Tao He; Hong Liu; Kun Yu (Science China Earth Sciences, 2022)

MAPK5 and MAPK10 overexpression influences strawberry fruit ripening, antioxidant capacity and resistance to Botrytis cinerea - Yunting Zhang; Yu Long; Yiting Liu; Min Yang; Liangxin Wang; Xiaoyang Liu; Yong Zhang; Qing Chen; Mengyao Li; Yuanxiu Lin; Haoru Tang; Ya Luo (Planta, 2022)

Serine protease HtrA2/Omi regulates adaptive mitochondrial reprogramming in the brain cortex after ischemia/reperfusion injury via UCP2-SIRT3-PGC1 axis - Hao Meng; Lian-Kun Sun; Jing Su; Wan-Yu Yan; Yao Jin; Xin Luo; Xian-Rui Jiang; Hong-Lei Wang (Human Cell, 2022)

Farming experience and farmers’ adoption of low-carbon management practices: the case of soil testing and fertilizer recommendations in China - Weizhen Yu; Xiaofeng Luo (Environmental Science and Pollution Research, 2022)

Experimental and numerical investigations of a catastrophic tailings dam break in Daye, Hubei, China - Yu Zhuang; Kaiping Jin; Qiangong Cheng; Aiguo Xing; Hao Luo (Bulletin of Engineering Geology and the Environment, 2022)

Stage correlation of symbiotic bacterial community and function in the development of litchi bugs (Hemiptera: Tessaratomidae) - Zhi-Hui Liu; Zi-Wen Yang; Jing Zhang; Jiu-Yang Luo; Yu Men; Yan-hui Wang; Qiang Xie (Antonie van Leeuwenhoek, 2022)

Submarine Groundwater and River Discharges Affect Carbon Cycle in a Highly Urbanized and River-Dominated Coastal Area - Xuejing Wang; Yan Zhang; Chunmiao Zheng; Manhua Luo; Shengchao Yu; Meiqing Lu; Hailong Li (Frontiers in Marine Science, 2021)
Riverine carbon flux to the ocean has been considered in estimating coastal carbon budgets, but submarine groundwater discharge (SGD) has long been ignored. In this paper, the effects of both SGD and river discharges on the carbon cycle were investigated in the Guangdong-HongKong-Macao Greater Bay Area (GBA), a highly urbanized and river-dominated coastal area in China. SGD-derived nitrate (NO 3 – ), dissolved organic carbon (DOC), and dissolved inorganic carbon (DIC) fluxes were estimated using a radium model to be (0.73–16.4) × 10 8 g/d, (0.60–9.94) × 10 9 g/d, and (0.77–3.29) × 10 10 g/d, respectively. SGD-derived DOC and DIC fluxes are ∼2 times as great as riverine inputs, but SGD-derived NO 3 – flux is one-fourth of the riverine input. The additional nitrate and carbon inputs can stimulate new primary production, enhance biological pump efficiency, and affect the balance of the carbonate system in marine water. We found that SGD in the studied system is a potential net source of atmospheric CO 2 with a flux of 1.46 × 10 9 g C/d, and river, however, is a potential net sink of atmospheric CO 2 with a flux of 3.75 × 10 9 g C/d during the dry winter season. Two conceptual models were proposed illustrating the major potential processes of the carbon cycle induced by SGD and river discharges. These findings from this study suggested that SGD, as important as rivers, plays a significant role in the carbon cycle and should be considered in carbon budget estimations at regional and global scales future.

Cytotoxic benzopyranone and xanthone derivatives from a coral symbiotic fungus Cladosporium halotolerans GXIMD 02502 - Chao-Nan Wang; Hu-Mu Lu; Cheng-Hai Gao; Lang Guo; Zhen-Yu Zhan; Jun-Jian Wang; Yong-Hong Liu; Song-Tao Xiang; Jian Wang; Xiao-Wei Luo (Natural Product Research, 2021)

Is a drought a drought in grasslands? Productivity responses to different types of drought - Charles J. W. Carroll; Ingrid J. Slette; Robert J. Griffin-Nolan; Lauren E. Baur; Ava M. Hoffman; Elsie M. Denton; Jesse E. Gray; Alison K. Post; Melissa K. Johnston; Qiang Yu; Scott L. Collins; Yiqi Luo; et al. (Oecologia, 2021)

Alantolactone exhibits antiproliferative and apoptosis-promoting properties in colon cancer model via activation of the MAPK-JNK/c-Jun signaling pathway - Yijing Ren; Cheng Lv; Jing Zhang; Beibei Zhang; Bei Yue; Xiaoping Luo; Zhilun Yu; Hao Wang; Junyu Ren; Zhengtao Wang; Wei Dou (Molecular and Cellular Biochemistry, 2021)

Comparing the effects of plant diversity on the nitrogen removal and stability in floating and sand-based constructed wetlands under ammonium/nitrate ratio disturbance - Yuanyuan Du; Shaodan Niu; Hang Jiang; Bin Luo; Qian Wang; Wenjuan Han; Yu Liu; Jie Chang; Ying Ge (Environmental Science and Pollution Research, 2021)

Ground vibration characteristics of carbon dioxide phase transition fracturing: an in situ test - Shengtao Zhou; Xuedong Luo; Nan Jiang; Shitong Zhang; Yu Lei (Bulletin of Engineering Geology and the Environment, 2021)

Retraction Note to: Analysis of atmospheric climate characteristics in coastal areas and the influence of educational cognition on industrial structure changes - Jiajia Yu; Qianrong Luo; Qian Gao (Arabian Journal of Geosciences, 2021)

Toward Understanding the Extreme Floods over Yangtze River Valley in June–July 2020: Role of Tropical Oceans - Shaolei Tang; Jing-Jia Luo; Jiaying He; Jiye Wu; Yu Zhou; Wushan Ying (Advances in Atmospheric Sciences, 2021)

The impact of teleconnections on the temporal dynamics in aboveground net primary productivity of the Mongolian Plateau grasslands - Cuicui Jiao; Guirui Yu; Xiaobo Yi; Wei Zhao; Liwei Xing; Fan He; Qiyu Li; Ji Luo (International Journal of Climatology, 2021)
Temporal dynamics in aboveground net primary productivity (ANPP) are significant for environmental protection and economic development in the Mongolian Plateau grasslands (MPGs). Climate control of ANPP's temporal variations has intensified in response to local meteorological conditions, while the contributions of large‐scale atmospheric circulations to ANPP variations are poorly understood in the MPGs. First, we explored the temporal dynamics in annual ANPP, and then, we analyzed correlations among annual ANPP, local meteorological variables, and three different teleconnections during 1982–2015 in this study. Our analytical results indicated that (a) ANPP exhibited an increasing trend during the entire study period. However, the increasing trend did not persist, and two reversals occurred in 1998 and 2007. (b) ANPP variations were primarily influenced by summer precipitation in most regions and by summer precipitation and temperature together in other regions of the MPGs. (c) The Atlantic Multidecadal Oscillation (AMO) in winter negatively dominated annual ANPP variations by influencing summer precipitation and summer temperature in central Mongolia. The North Atlantic Oscillation (NAO) in winter exerted strong positive impacts on ANPP variations by influencing summer precipitation in Inner Mongolia, China. The East Atlantic Western Russia (EAWR) in spring controlled annual ANPP variations by influencing summer precipitation in western and eastern Mongolia. (d) The winter AMO, winter NAO and spring EAWR significantly dominated the annual ANPP variations in 49.78% of the MPGs, with values of 18.90, 9.81 and 21.07%, respectively. (e) Reversals of the winter AMO, winter NAO and spring EAWR between negative and positive phases resulted in two reversals of ANPP trends. This study will improve our understanding of the role of large‐scale atmospheric circulations in regulating ANPP variations and will be valuable in guiding the development of grazing land management in Mongolia and Inner Mongolia, China.

Cannabinoid receptor GPR55 activation blocks nicotine use disorder by regulation of AMPAR phosphorylation - Qingqing Liu; Jiaoyan Yu; Xi Li; Yanyan Guo; Ting Sun; Li Luo; Jing Ren; Wei Jiang; Ruitao Zhang; Peng Yang; Qi Yang (Psychopharmacology, 2021)

The co-expression of genes involved in seed coat and endosperm development promotes seed abortion in grapevine - Shasha Li; Xiangyu Geng; Shuo Chen; Keke Liu; Saisai Yu; Xiping Wang; Chaohong Zhang; Jianxia Zhang; Yingqiang Wen; Qiangwei Luo; Yan Xu; Yuejin Wang (Planta, 2021)

Drivers of changes in soil properties during post-fire succession on Dahurian larch forest - Yuetai Weng; Zhaoguo Li; Sisheng Luo; Zhangwen Su; Xueying Di; Guang Yang; Hongzhou Yu; Dongdong Han (Journal of Soils and Sediments, 2021)

First report of bacterial brown rot disease on shiitake mushroom (Lentinula edodes) caused by Ewingella americana in Korea - WonJun Na; Huan Luo; Jun Myoung Yu (Journal of Plant Pathology, 2021)

Two new isoquinoline alkaloids from the seeds of Nandina domestica - Juan Qin; Sheng-Yuan Zhang; Yu-Bo Zhang; Li-Feng Chen; Neng-Hua Chen; Zhong-Nan Wu; Ding Luo; Guo-Cai Wang; Yao-Lan Li (Natural Product Research, 2021)

Implantation of Bone Marrow Mesenchymal Stem Cells into Small Intestinal Submucosa Improves Bile Duct Injury in Rabbits - Ying Li; Piao Wang; Xiao-dong Hu; Jing-da Zeng; Cheng Fang; Yu Gan; Fang-yi Peng; Xiao-li Yang; De Luo; Bo Li; Song Su (Tissue Engineering and Regenerative Medicine, 2021)

The application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis - Junchao Luo; Yin Zhang; Senbo Zhu; Yu Tong; Lichen Ji; Wei Zhang; Qiong Zhang; Qing Bi (Naunyn-Schmiedeberg's Archives of Pharmacology, 2021)
The current understanding of osteoarthritis is developing from a mechanical disease caused by cartilage wear to a complex biological response involving inflammation, oxidative stress and other aspects. Nanoparticles are widely used in drug delivery due to its good stability in vivo and cell uptake efficiency. In addition to the above advantages, metal/metal oxide NPs, such as cerium oxide and manganese dioxide, can also simulate the activity of antioxidant enzymes and catalyze the degradation of superoxide anions and hydrogen peroxide. Degrading of metal/metal oxide nanoparticles releases metal ions, which may slow down the progression of osteoarthritis by inhibiting inflammation, promoting cartilage repair and inhibiting cartilage ossification. In present review, we focused on recent research works concerning osteoarthritis treating with metal/metal oxide nanoparticles, and introduced some potential nanoparticles that may have therapeutic effects.

Experimental study on the suffusion mechanism of gap-graded soils under an exceedance hydraulic gradient - Liang Chen; Yu Wan; Jian-Jian He; Chun-Mu Luo; Shu-Fa Yan; Xian-Feng He (Natural Hazards, 2021)

Integrated 16S rRNA Gene Sequencing and LC-MS Analysis Revealed the Interplay Between Gut Microbiota and Plasma Metabolites in Rats With Ischemic Stroke - Wanfeng Wu; Yihang Sun; Ning Luo; Cheng Cheng; Chengting Jiang; Qingping Yu; Shaowu Cheng; Jinwen Ge (Journal of Molecular Neuroscience, 2021)

The impacts of different anticoagulants and long-term frozen storage on multiple metal concentrations in peripheral blood: a comparative study - Yu Bao; Xiaoting Ge; Longman Li; Junxiu He; Sifang Huang; Xiaoyu Luo; Xing Chen; Pan Chen; Xiaobo Yang (BioMetals, 2021)

Autophagy induced by H. pylori VacA regulated the survival mechanism of the SGC7901 human gastric cancer cell line - Juan Luo; Luyan Bai; Jun Tao; Yu Wen; Mingke Li; Yunzhen Zhu; Sufeng Luo; Guangyu Pu; Lanqing Ma (Genes & Genomics, 2021)
Background Vacuolating cytotoxin (VacA) is an important virulence factor of Helicobacter pylori ( H. pylori ). It was previously believed that VacA can trigger the cascade of apoptosis on mitochondria to lead to cell apoptosis. Recently, it was found that VacA can induce autophagy. However, the molecular mechanism by which VacA induces autophagy is largely unknown. Objective We aimed to explore the molecular mechanism of autophagy induced by H. pylori in gastric cancer cells and the effect of autophagy on the survival of gastric cancer cells. Methods The autophagy of human gastric cancer cell line SGC7901 was detected by Western blot and RT-PCR in the treatment of VacA protein of H. pylori . The relationship between autophagy and reactive oxygen species (ROS) in the proliferation of gastric cancer cells were studied by gene expression silences (siRNA) and CM-H2DCFDA (DCF) staining. Results The results showed that VacA protein secreted by H. pylori in the supernatant stimulated autophagy in SGC7901 cells. After VacA protein treatment, the mRNA expressions of BECN1, ATG7 and PIK3C3, were up-regulated. ATG7 silencing by siRNA inhibited VacA-induced autophagy. Furthermore, our data demonstrated that VacA protein increased ROS levels. Addition of the antioxidant N -acetyl- l -cysteine (NAC) suppressed the levels of ROS, leading to inhibition of autophagy. Conclusions H. pylori VacA is a key toxin that induces autophagy by increased ROS levels. And our findings demonstrated that VacA significantly inhibited proliferation in SGC7901 cells.

Sandaracinobacteroides hominis gen. nov., sp. nov., isolated from human skin - Ping-Hua Qu; Hai-Min Luo; Jun-Hui Feng; Song Li; Cha Chen; Lei Dong; Yu-Zhen Ming; Wen-Jun Li; Ying Lin (Archives of Microbiology, 2021)

Plant traits and soil fertility mediate productivity losses under extreme drought in C 3 grasslands - Wentao Luo; Robert J. Griffin‐Nolan; Wang Ma; Bo Liu; Xiaoan Zuo; Chong Xu; Qiang Yu; Yahuang Luo; Pierre Mariotte; Melinda D. Smith; Scott L. Collins; Alan K. Knapp; et al. (Ecology, 2021)
Extreme drought decreases aboveground net primary production (ANPP) in most grasslands, but the magnitude of ANPP reductions varies especially in C 3 ‐dominated grasslands. Because the mechanisms underlying such differential ecosystem responses to drought are not well resolved, we experimentally imposed an extreme 4‐yr drought (2015–2018) in two C 3 grasslands that differed in aridity. These sites had similar annual precipitation and dominant grass species ( Leymus chinensis ) but different annual temperatures and thus water availability. Drought treatments differentially affected these two semiarid grasslands, with ANPP of the drier site reduced more than at the wetter site. Structural equation modeling revealed that community‐weighted means for some traits modified relationships between soil moisture and ANPP, often due to intraspecific variation. Specifically, drought reduced community mean plant height at both sites, resulting in a reduction in ANPP beyond that attributable to reduced soil moisture alone. Higher community mean leaf carbon content enhanced the negative effects of drought on ANPP at the drier site, and ANPP–soil‐moisture relationships were influenced by soil C:N ratio at the wetter site. Importantly, neither species richness nor functional dispersion were significantly correlated with ANPP at either site. Overall, as expected, soil moisture was a dominant, direct driver of ANPP response to drought, but differential sensitivity to drought in these two grasslands was also related to soil fertility and plant traits.

A Finite Element Model for Underwater Sound Propagation in 2-D Environment - Yi-Qing Zhou; Wen-Yu Luo (Journal of Marine Science and Engineering, 2021)
The finite element method is a popular numerical method in engineering applications. However, there is not enough research about the finite element method in underwater sound propagation. The finite element method can achieve high accuracy and great universality. We aim to develop a three-dimensional finite element model focusing on underwater sound propagation. As the foundation of this research, we put forward a finite element model in the Cartesian coordinate system for a sound field in a two-dimensional environment. We firstly introduce the details of the implementation of the finite element model, as well as different methods to deal with boundary conditions and a comparison of these methods. Then, we use four-node quadrilateral elements to discretize the physical domain, and apply the perfectly matched layer approach to deal with the infinite region. After that, we apply the model to underwater sound propagation problems including the wedge-shaped waveguide benchmark problem and the problem where the bathymetry consists of a sloping region and a flat region. The results by the presented finite element model are in excellent agreement with analytical and benchmark numerical solutions, implying that the presented finite element model is able to solve complex two-dimensional underwater sound propagation problems accurately. In the end, we compare the finite element model with the popular normal mode model KRAKEN by calculating sound fields in Pekeris waveguides, and find that the finite element model has better universality than KRAKEN.

Schisandrae chinensis fructus extract protects against hepatorenal toxicity and changes metabolic ions in cyclosporine A rats - Yanyan Wei; Zhengzhong Luo; Kang Zhou; Quanwu Wu; Wen Xiao; Yang Yu; Tongming Li (Natural Product Research, 2021)

Correlations between Dual-Pathway White Matter Alterations and Language Impairment in Patients with Aphasia: A Systematic Review and Meta-analysis - Jie Zhang; Shuchang Zhong; Liang Zhou; Yamei Yu; Xufei Tan; Min Wu; Peng Sun; Wei Zhang; Juebao Li; Ruidong Cheng; Yanfei Wu; Yanmei Yu; et al. (Neuropsychology Review, 2021)

Correction to: Decomposition of substrates with recalcitrance gradient, primed CO2, and its relations with soil microbial diversity in post‑fire forest soils - Jie Zhang; Lu Ling; Bhupinder Pal Singh; Yu Luo; Peduruhewa H. Jeewani; Jianming Xu (Journal of Soils and Sediments, 2021)

Decomposition of substrates with recalcitrance gradient, primed CO2, and its relations with soil microbial diversity in post-fire forest soils - Jie Zhang; Lu Ling; Bhupinder Pal Singh; Yu Luo; Peduruhewa H. Jeewani; Jianming Xu (Journal of Soils and Sediments, 2021)

miR-181a Mediates Inflammatory Gene Expression After Intracerebral Hemorrhage: An Integrated Analysis of miRNA-seq and mRNA-seq in a Swine ICH Model - Kyle B. Walsh; Kip D. Zimmerman; Xiang Zhang; Stacie L. Demel; Yu Luo; Carl D. Langefeld; Eric Wohleb; Grant Schulert; Daniel Woo; Opeolu Adeoye (Journal of Molecular Neuroscience, 2021)

Complex analysis of the personalized pharmacotherapy in the management of COVID-19 patients and suggestions for applications of predictive, preventive, and personalized medicine attitude - Lei-Yun Wang; Jia-Jia Cui; Qian-Ying OuYang; Yan Zhan; Yi-Min Wang; Xiang-Yang Xu; Lu-Lu Yu; Hui Yin; Yang Wang; Chen-Hui Luo; Cheng-Xian Guo; Ji-Ye Yin (EPMA Journal, 2021)
Aims Coronavirus disease 2019 (COVID-19) is rapidly spreading worldwide. Drug therapy is one of the major treatments, but contradictory results of clinical trials have been reported among different individuals. Furthermore, comprehensive analysis of personalized pharmacotherapy is still lacking. In this study, analyses were performed on 47 well-characterized COVID-19 drugs used in the personalized treatment of COVID-19. Methods Clinical trials with published results of drugs use for COVID-19 treatment were collected to evaluate drug efficacy. Drug-to-Drug Interactions (DDIs) were summarized and classified. Functional variations in actionable pharmacogenes were collected and systematically analysed. “Gene Score” and “Drug Score” were defined and calculated to systematically analyse ethnicity-based genetic differences, which are important for the safer use of COVID-19 drugs. Results Our results indicated that four antiviral agents (ritonavir, darunavir, daclatasvir and sofosbuvir) and three immune regulators (budesonide, colchicine and prednisone) as well as heparin and enalapril could generate the highest number of DDIs with common concomitantly utilized drugs. Eight drugs (ritonavir, daclatasvir, sofosbuvir, ribavirin, interferon alpha-2b, chloroquine, hydroxychloroquine (HCQ) and ceftriaxone had actionable pharmacogenomics (PGx) biomarkers among all ethnic groups. Fourteen drugs (ritonavir, daclatasvir, prednisone, dexamethasone, ribavirin, HCQ, ceftriaxone, zinc, interferon beta-1a, remdesivir, levofloxacin, lopinavir, human immunoglobulin G and losartan) showed significantly different pharmacogenomic characteristics in relation to the ethnic origin of the patient. Conclusion We recommend that particularly for patients with comorbidities to avoid serious DDIs, the predictive, preventive, and personalized medicine (PPPM, 3 PM) strategies have to be applied for COVID-19 treatment, and genetic tests should be performed for drugs with actionable pharmacogenes, especially in some ethnic groups with a higher frequency of functional variations, as our analysis showed. We also suggest that drugs associated with higher ethnic genetic differences should be given priority in future pharmacogenetic studies for COVID-19 management. To facilitate translation of our results into clinical practice, an approach conform with PPPM/3 PM principles was suggested. In summary, the proposed PPPM/3 PM attitude should be obligatory considered for the overall COVID-19 management.

Human Methylmercury Exposure and Potential Impacts in Central Tibet: Food and Traditional Tibetan Medicine - Menghan Cheng; Maodian Liu; Dou Li; Qing Luo; Zhihao Zhang; Liuliang Yuan; Chenghao Yu; Han Xie; Huiming Lin; Qianru Zhang; De Ji; Xuejun Wang (Bulletin of Environmental Contamination and Toxicology, 2021)

Protective effect of Bombyx mori gloverin on intestinal epithelial cells exposure to enterotoxigenic E. coli - Qian Lin; Qingqing Fu; Guoqi Su; Daiwen Chen; Bing Yu; Yuheng Luo; Ping Zheng; Xiangbing Mao; Zhiqing Huang; Jie Yu; Junqiu Luo; Hui Yan; et al. (Brazilian Journal of Microbiology, 2021)

Spatiotemporal variations of wetlands in the northern Xinjiang with relationship to climate change - Nana Luo; Rui Yu; Dehua Mao; Bolong Wen; Xingtu Liu (Wetlands Ecology and Management, 2021)

The relationship between anthocyanin accumulation and photoprotection in young leaves of two dominant tree species in subtropical forests in different seasons - Zheng-Chao Yu; Wei Lin; Xiao-Ting Zheng; Wah Soon Chow; Yan-Na Luo; Min-Ling Cai; Chang-Lian Peng (Photosynthesis Research, 2021)

The mTOR/NF-κB Pathway Mediates Neuroinflammation and Synaptic Plasticity in Diabetic Encephalopathy - Ting Xu; Jiao Liu; Xin-rui Li; Yinghua Yu; Xuan Luo; Xian Zheng; Yuan Cheng; Pei-quan Yu; Yi Liu (Molecular Neurobiology, 2021)

Nutrients addition regulates temperature sensitivity of maize straw mineralization - Muhammad Auwal; Bhupinder Pal Singh; Zhiyi Chen; Amit Kumar; Shaotong Pan; Yu Luo; Jianming Xu (Journal of Soils and Sediments, 2021)

A multi-domain prognostic model of disorder of consciousness using resting-state fMRI and laboratory parameters - Yamei Yu; Fanxia Meng; Li Zhang; Xiaoyan Liu; Yuehao Wu; Sicong Chen; Xufei Tan; Xiaoxia Li; Sheng Kuang; Yu Sun; Benyan Luo (Brain Imaging and Behavior, 2021)

The exploration of Parkinson’s disease: a multi-modal data analysis of resting functional magnetic resonance imaging and gene data - Xia-an Bi; Hao Wu; Yiming Xie; Lixia Zhang; Xun Luo; Yu Fu (Brain Imaging and Behavior, 2021)

Abnormal white matter tracts of insula in smokers - Chao Wang; Shuyue Wang; Peiyu Huang; Zhujing Shen; Wei Qian; Xiao Luo; Kaicheng Li; Qingze Zeng; Quanquan Gu; Hualiang Yu; Yihong Yang; Minming Zhang (Brain Imaging and Behavior, 2021)

Intrinsic low-frequency oscillation changes in multiple-frequency bands in stable patients with chronic obstructive pulmonary disease - Jingjing Yu; Wenjing Wang; Dechang Peng; Juan Luo; Huizhen Xin; Honghui Yu; Juan Zhang; Lan Li; Haijun Li (Brain Imaging and Behavior, 2021)

Transcriptome Analysis on Asymmetric Root Growth of Oryza sativa Induced by Brassinosteroids via Ethylene Pathway - Zeping Cai; Zhen Huang; Chujun Huang; Xia Jin; Wen Yang; Gengbo Jiang; Zixuan Wang; Fanhua Wu; Xudong Yu; Jiajia Luo (Journal of Plant Biology, 2021)

Metagenomic insights into soil microbial communities involved in carbon cycling along an elevation climosequences - Zhongmin Dai; Huadong Zang; Jie Chen; Yingyi Fu; Xuehua Wang; Huaiting Liu; Congcong Shen; Jianjun Wang; Yakov Kuzyakov; Joscha N. Becker; Andreas Hemp; Albert Barberán; et al. (Environmental Microbiology, 2021)
Summary Diversity and community composition of soil microorganisms along the elevation climosequences have been widely studied, while the microbial metabolic potential, particularly in regard to carbon (C) cycling, remains unclear. Here, a metagenomic analysis of C related genes along five elevations ranging from 767 to 4190 m at Mount Kilimanjaro was analysed to evaluate the microbial organic C transformation capacities in various ecosystems. The highest gene abundances for decomposition of moderate mineralizable compounds, i.e. carbohydrate esters, chitin and pectin were found at the mid‐elevations with hump‐shaped pattern, where the genes for decompositions of recalcitrant C (i.e. lignin) and easily mineralizable C (i.e. starch) showed the opposite trend (i.e. U‐shaped pattern), due to high soil pH and seasonality in both low and high elevations. Notably, the gene abundances for the decompositions of starch, carbohydrate esters, chitin and lignin had positive relationships with corresponding C compounds, indicating the consistent responses of microbial functional profiles and metabolites to elevation climosequences. Understanding of adaptation of microbial communities, potential function and metabolites to elevation climosequences and their influencing factors provided a new insight for the regulation of terrestrial C storage.

Chemicals from lignocellulosic biomass: A critical comparison between biochemical, microwave and thermochemical conversion methods - Iris K. M. Yu; Huihui Chen; Felix Abeln; Hadiza Auta; Jiajun Fan; Vitaly L. Budarin; James H. Clark; Sophie Parsons; Christopher J. Chuck; Shicheng Zhang; Gang Luo; Daniel C.W Tsang (Critical Reviews in Environmental Science and Technology, 2021)

Dynamic response of flexible rockfall barriers with different block shapes - Zhixiang Yu; Liru Luo; Chun Liu; Liping Guo; Xin Qi; Lei Zhao (Landslides, 2021)

Mapping fetal brain development based on automated segmentation and 4D brain atlasing - Haotian Li; Guohui Yan; Wanrong Luo; Tingting Liu; Yan Wang; Ruibin Liu; Weihao Zheng; Yi Zhang; Kui Li; Li Zhao; Catherine Limperopoulos; Yu Zou; et al. (Brain Structure and Function, 2021)

Carbon storage of the forest and its spatial pattern in Tibet, China - Long-yu Jia; Gen-xu Wang; Ji Luo; Fei Ran; Wei Li; Jun Zhou; Dan-li Yang; Wen-bo Shi; Qian Xu; Kun Zhu; Yang Yang (Journal of Mountain Science, 2021)

Activation of Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) with Lidocaine Provokes Pyroptosis of Glioblastoma Cells - B. Zhou; Y. Lin; S. Chen; J. Cai; Z. Luo; S. Yu; J. Lu (Bulletin of Experimental Biology and Medicine, 2021)

RETRACTED ARTICLE: Analysis of atmospheric climate characteristics in coastal areas and the influence of educational cognition on industrial structure changes - Jiajia Yu; Qianrong Luo; Qian Gao (Arabian Journal of Geosciences, 2021)

Identification of the related genes on the asymmetric root growth of Oryza sativa induced by ethylene through transcriptome sequencing, GO and KEGG analysis - Zeping Cai; Zhen Huang; Zixuan Wang; Yu Tao; Fanhua Wu; Xudong Yu; Jiajia Luo (Acta Physiologiae Plantarum, 2021)

Programmed sequential cutting endows Cas9 versatile base substitution capability in plants - Wei Yang; Wei Qi; Yucai Li; Jiyao Wang; Yanmin Luo; Dehui Ding; Sudong Mo; Bo Chen; Yu Lu; Huarong Li; Linjian Jiang (Science China Life Sciences, 2021)

Rhizosphere microbiome modulated effects of biochar on ryegrass 15N uptake and rhizodeposited 13C allocation in soil - Yingyi Fu; Amit Kumar; Lijun Chen; Yuji Jiang; Ning Ling; Runze Wang; Qiong Pan; Bhupinder Pal Singh; Marc Redmile-Gordon; Lu Luan; Qin Li; Quan Shi; et al. (Plant and Soil, 2021)

Conserved residue PsaB-Trp673 is essential for high-efficiency electron transfer between the phylloquinones and the iron-sulfur clusters in Photosystem I - Vasily Kurashov; George Milanovsky; Lujun Luo; Antoine Martin; Alexey Yu. Semenov; Sergei Savikhin; Dmitry A. Cherepanov; John H. Golbeck; Wu Xu (Photosynthesis Research, 2021)

An underlying mechanism of qE deficiency in marine angiosperm Zostera marina - Wei Zhao; Quan Sheng Zhang; Ying Tan; Zhe Liu; Ming Yu Ma; Meng Xin Wang; Cheng Ying Luo (Photosynthesis Research, 2021)

Genetic Architecture of Childhood Kidney and Urological Diseases in China - Ye Fang; Hua Shi; Tianchao Xiang; Jiaojiao Liu; Jialu Liu; Xiaoshan Tang; Xiaoyan Fang; Jing Chen; Yihui Zhai; Qian Shen; Guomin Li; Li Sun; et al. (Phenomics, 2021)
Kidney disease is manifested in a wide variety of phenotypes, many of which have an important hereditary component. To delineate the genotypic and phenotypic spectrum of pediatric nephropathy, a multicenter registration system is being implemented based on the Chinese Children Genetic Kidney Disease Database (CCGKDD). In this study, all the patients with kidney and urological diseases were recruited from 2014 to 2020. Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features. The genetic diagnosis was confirmed in 883 of 2256 (39.1%) patients from 23 provinces in China. Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome (SRNS, 23.5%), glomerulonephritis (GN, 32.2%), congenital anomalies of the kidney and urinary tract (CAKUT, 21.2%), cystic renal disease (3.9%), renal calcinosis/stone (3.6%), tubulopathy (9.7%), and chronic kidney disease of unknown etiology (CKDu, 5.8%). The pathogenic variants of 105 monogenetic disorders were identified. Ten distinct genomic disorders were identified as pathogenic copy number variants (CNVs) in 11 patients. The diagnostic yield differed by subgroups, and was highest in those with cystic renal disease (66.3%), followed by tubulopathy (58.4%), GN (57.7%), CKDu (43.5%), SRNS (29.2%), renal calcinosis /stone (29.3%) and CAKUT (8.6%). Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions. We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed. Our data demonstrate the utility of family-based exome sequencing, and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease.

Five matrine-type alkaloids from Sophora tonkinensis - Qing Tang; Ding Luo; Ding-Chai Lin; Wen-Zhi Wang; Can-Jie Li; Xue-Fang Zhuo; Zhong-Nan Wu; Yu-Bo Zhang; Guo-Cai Wang; Yao-Lan Li (Journal of Natural Medicines, 2021)

Screening of sweet wampee [Clausena lansium (Lour.) Skeels] progenies in the early growth stage based on chloroplast genome analysis - Zhichang Zhao; Aiping Gao; Jiangfeng Huang; Ruixiong Luo; Kaili Yu (Genetic Resources and Crop Evolution, 2021)

Diversity of Diaporthe species associated with melanose disease on citrus trees in Jiangxi Province, China - Zhe-Zheng Zeng; Chingchai Chaisiri; Xiang-Yu Liu; Yang Lin; Chao-Xi Luo (European Journal of Plant Pathology, 2021)

The effects of dark treatment on photosynthesis and growth in young and mature leaves of Syzygium rehderianum - ZhengChao Yu; Wei Lin; XiaoTing Zheng; YanNa Luo; ChangLian Peng (Brazilian Journal of Botany, 2021)

Estimates of additive and non-additive genetic effects on growth traits in a diallel cross of three strains of pearl oyster (Pinctada fucata) - Jian Chen; Hui Luo; Ziqin Zhai; Hongchen Wang; Baosuo Liu; Lirong Bai; Dahui Yu (Aquaculture International, 2021)

Expression and regulation of ccBAX by miR‐124 in the caudal fin cell of C. auratus gibelio upon cyprinid herpesvirus 2 infection - Lu Yu; Qikang Chen; Xin Chu; Yang Luo; Zizhao Feng; Liqun Lu; Ye Zhang; Dan Xu (Journal of Fish Diseases, 2021)
Bcl2 family proteins play a critical role in cell death or survival. BAX, the death‐promoting protein of bcl2 family, mediated mitochondrial pathway inducing cells’ apoptosis in mammal. MiRNAs have been implicated as negative regulators down‐regulating genes’ expression after post‐transcriptional level. At present, little is known about the regulatory mechanism of miRNA on the Bcl2 family proteins during CyHV‐2 infection in silver crucian carp ( Carassius auratus gibelio ). In this study, the ccBAX (silver crucian carp BAX) gene was cloned and expressed, and polyclonal antibodies were raised in mouse against the purified ccBAX‐GST fusion protein. The structure analysis indicated that ccBAX protein included four conserve domains (BH1, BH2, BH3 and transmembrane domains) and the expression of ccBAX protein occurred throughout the cells. Furthermore, two miRNAs (miR‐124 and miRNA‐29b) were identified to negatively regulate ccBAX gene expression in GiCF cell. miR‐124 was found to suppress the expression of WT‐ccBAX (wild type), but not the MT‐ccBAX (mutant). Overall, the results demonstrated that the expression of the ccBAX gene was significantly down‐regulated by miR‐124 in silver crucian carp ( Carassius auratus gibelio ) during CyHV‐2 infection.

Super-enrichment of lithium and niobium in the upper Permian Heshan Formation in Pingguo, Guangxi, China - Kunyue Ling; Hanjie Wen; Qizuan Zhang; Chongguang Luo; Hannian Gu; Shengjiang Du; Wenxiu Yu (Science China Earth Sciences, 2021)

Amygdala-based Functional Network Reveals Dissociated Neural Correlates of Consensual and Idiosyncratic Emotional Movie Experiences - Lin Cui; Bingbing Guo; Dan Zhao; Jiaxin Li; Yu Luo; Ming Meng (Neuroscience Bulletin, 2021)