Monoterpenoid indole alkaloids with potential neuroprotective activities from the stems and leaves of Melodinus cochinchinensis - Yu-Jie Li; Juan Li; Lan Xie; Jun-Yu Zhou; Qiu-Xuan Li; Rui-Yuan Yang; Yan-Ping Liu; Yan-Hui Fu (Natural Product Research, 2022)

Evaluation and prediction of land use change impacts on ecosystem service values in Nanjing City from 1995 to 2030 - Ping Yu; Shuainan Zhang; Peng Wang; Yingnan Li; Lei Huang (Environmental Science and Pollution Research, 2022)

Forecasting Hourly Intermittent Rainfall by Deep Belief Networks with Simple Exponential Smoothing - Guo-Yu Huang; Chi-Ju Lai; Ping-Feng Pai (Water Resources Management, 2022)

Investigating and predicting spatiotemporal variations in vegetation cover in transitional climate zone: a case study of Gansu (China) - Qing He; Kwok Pan Chun; Bastien Dieppois; Liang Chen; Ping Yu Fan; Emir Toker; Omer Yetemen; Xicai Pan (Theoretical and Applied Climatology, 2022)
Vegetation ecosystems are sensitive to large-scale climate variability in climate transition zones. As a representative transitional climate zone in Northwest China, Gansu is characterized by a sharp climate and vegetation gradient. In this study, the spatiotemporal variations of vegetation over Gansu are characterized using the satellite-based normalized difference vegetation index (NDVI) observations during 2000–2020. Results demonstrate that a significant greening trend in vegetation over Gansu is positively linked with large-scale climate factors through modulating the water and energy dynamics. As a climate transition zone, the northern water-limited and southern energy-limited regions of Gansu are affected by water and energy dynamics, differently. In the water-limited region, a weakening Asian monsoon along with colder Central Pacific (CP) and warmer North Pacific (NP) Oceans enhances prevailing westerlies which bring more atmospheric moisture. The enhanced atmospheric moisture and rising temperature promote the local vegetation growth. In contrast, large-scale climate variations suppress the southwest monsoon moisture fluxes and reduce precipitation in southern energy-limited regions. In these energy-limited regions, temperature has more effects on vegetation growth than precipitation. Therefore, the greenness of vegetation is because of more available energy from higher temperatures despite overall drying conditions in the region. Based on the above mechanism, future scenarios for climate impacts on vegetation cover over Gansu region are developed based on the two latest generation from coupled climate models (Coupled Model Intercomparison Project Phase 5 and Phase 6; CMIP5 and CMIP6). In the near-term future (2021–2039), the vegetation is likely to increase due to rising temperature. However, the vegetation is expected to decrease in a long-term future (2080–2099) when the energy-limited regions become water-limited due to increasing regional temperatures and lowering atmospheric moisture flux. This study reveals an increasing desertification risk over Gansu. Similar investigations will be valuable in climate transition regions worldwide to explore how large-scale climate variability affects local ecological services under different future climate scenarios.

Lower abundance of Bacteroides and metabolic dysfunction are highly associated with the post-weaning diarrhea in piglets - Wen Ren; Bing Yu; Jie Yu; Ping Zheng; Zhiqing Huang; Junqiu Luo; Xiangbing Mao; Jun He; Hui Yan; Jinlong Wu; Daiwen Chen; Yuheng Luo (Science China Life Sciences, 2022)

Stability Evaluation Method and Support Structure Optimization of Weak and Fractured Slate Tunnel - Ping Zhou; Yifan Jiang; Feicong Zhou; Lun Gong; Wenge Qiu; Jingwen Yu (Rock Mechanics and Rock Engineering, 2022)

Sulfur fertiliser enhancement of Erigeron breviscapus (Asteraceae) quality by improving plant physiological responses and reducing soil cadmium bioavailability - Yonglin Liu; Yingpin Liu; Yu Chen; Ping Zhao; Shengchao Yang; Shuran He; Guangqiang Long (Environmental Science and Pollution Research, 2022)

Methods to control harmful algal blooms: a review - Barathan Balaji-Prasath; Ying Wang; Yu Ping Su; David P. Hamilton; Hong Lin; Luwei Zheng; Yong Zhang (Environmental Chemistry Letters, 2022)

Oceanobacillus saliphilus sp. nov., Isolated from Saline−Alkali Soil in Heilongjiang Province, China - Yu-Ting OuYang; Meng-Meng Li; Ai-Ping Lv; Pin-Jiao Jin; Lan Liu; Ze-Tao Liu; Jian-Yu Jiao; Wen-Jun Li; Li-Xiang Cao; Shuang Wang (Current Microbiology, 2022)

Role of ocean dynamics in equatorial Pacific decadal variability - Yu Zhang; Shi-Yun Yu; Shang-Ping Xie; Dillon J. Amaya; Qihua Peng; Yu Kosaka; Xiaopei Lin; Jun-Chao Yang; Sarah M. Larson; Arthur J. Miller; Lei Fan (Climate Dynamics, 2022)

Differential expression and functional analysis of circRNA in the ovaries of Yili geese at different egg-laying stages - Xiao-yu Zhao; Ying-ping Wu; Hai-ying Li; Yan Cao; Zhi-yong Mei; Jia-hui Li (Genes & Genomics, 2022)

Functional analysis of HADH c.99C>G shows that the variant causes the proliferation of pancreatic islets and leu-sensitive hyperinsulinaemia - Wu Long; Yue-Bing Wang; Peng-Fei Qu; Lin Ma; Si-Jie Wei; Yan-Mei Xi; Jin-Liang Du; Xue Tang; Kai Liu; Yu-Hua Li; Pu-Ping Lei (Journal of Genetics, 2022)

Exploring the R-ISS stage-specific regular networks in the progression of multiple myeloma at single-cell resolution - Ling Zhong; Xiao Yang; Yu Zhou; Jialing Xiao; Huan Li; Jiang Tao; Qian Xi; Chen Chu; Chenglong Li; Xi Yang; Chen Yang; Yi Zhang; et al. (Science China Life Sciences, 2022)

WASHC1 interacts with MCM2-7 complex to promote cell survival under replication stress - Yu Hong; He Sun; Xian Hong; Cai-Ping Yang; Daniel D. Billadeau; Tao Wang; Zhi-Hui Deng (Molecular Biology Reports, 2022)

Phylogeny and species diversity in Hygrophorus section Aurei in China - Hong-Yan Huang; Wen-Hao Zhang; Ting Huang; Gabriel Moreno; Yun-Ju Pu; Yu-Guang Fan; Shu-Da Yang; Tie-Zhi Liu; Li-Ping Tang (Mycological Progress, 2022)

Dissecting the role of cell signaling versus CD8+ T cell modulation in propranolol antitumor activity - Wei Li; Jielin Wan; Cuiyu Chen; Chengfang Zhou; Ping Liao; Qian Hu; Jiali Hu; Yang Wang; Yu Zhang; Cong Peng; Yuanfei Huang; Weihua Huang; et al. (Journal of Molecular Medicine, 2022)

De novo RNA sequencing for identification of growth-related genes in Silurus lanzhouensis muscle tissues - Wei Xiao; Zong-Qiang Lian; Jian-Ping Wu; Xu-Dong Wu; Zhao-Xi Yu; Qing-Yun Sai (Fisheries Science, 2022)

Influence of microplastics on triclosan bioaccumulation and metabolomics variation in Tilapia fish tissues - Yu-Wei Jia; Ping Wang; Sheng Yang; Zheng Huang; Yue-Hong Liu; Jian-Liang Zhao (Environmental Science and Pollution Research, 2022)

Recent advances in metabolic regulation and bioengineering of gibberellic acid biosynthesis in Fusarium fujikuroi - Hao-Nan Wang; Xia Ke; Jun-Ping Zhou; Zhi-Qiang Liu; Yu-Guo Zheng (World Journal of Microbiology and Biotechnology, 2022)

Ketone Body Rescued Seizure Behavior of LRP1 Deficiency in Drosophila by Modulating Glutamate Transport - Jin-Ming Zhang; Ming-Jie Chen; Jiong-Hui He; Ya-Ping Li; Zhi-Cai Li; Zi-Jing Ye; Yong-Hui Bao; Bing-Jun Huang; Wen-Jie Zhang; Ping Kwan; Yu-Ling Mao; Jing-da Qiao (Journal of Molecular Neuroscience, 2022)

The Effects of Diameter, Length and Insertion Method on the Stability of Orthodontic Miniscrew - Wan-Ping Yu; Jian-Hong Yu; Shiuan-Hui Wang; Jui-Ting Hsu (Journal of Medical and Biological Engineering, 2022)

Trochanteric Nails for the Reduction of Intertrochanteric Fractures: A Biomechanical Analysis Based on Finite Element Analysis and DIC System - Ming-Tzu Tsai; Cheng-Hung Lee; Kun-Hui Chen; Yu-Chun Yen; Chun-Hsiang Wang; Shun-Ping Wang; Kuo-Chih Su (Journal of Medical and Biological Engineering, 2022)
Purpose Intertrochanteric fractures are common among femoral fractures in the elderly population. The trochanteric nail is a standard internal fixator used in treating femoral intertrochanteric fractures. The technique of femoral fracture reduction affects the postoperative outcome. Here, we applied finite element analysis (FEA) to study mechanical effects of different reduction approaches using the trochanteric nail in treating both stable and unstable intertrochanteric fractures. Methods We combined FEA and in vitro experiments using a digital imaging correlation (DIC) technique to study effects of different alignment conditions after treating 4 cases of intertrochanteric fractures using the trochanteric nail system. A downward force of 2250 N was applied to the femoral head, and the distal end of the femur was fixed. The observed indicators were the femur displacement, together with the stress on the femur and trochanteric nail system. In addition, the displacement distribution was analyzed using DIC. Results In the case of space reduction, the force was transmitted by the trochanteric nail system, resulting in greater stress imposed on the femur or the trochanteric nail system. In the case of closed reduction, the stress was much smaller. In the case of unstable fracture reduction, closed reduction was associated with a smaller contact area at the fracture site, resulting in greater stress on both trochanter and the trochanteric nail system. Conclusion When the trochanteric nail system was used for fixation, the fracture site was well aligned, reducing the stress on the femur or the trochanteric nail.

Microfluidic preparation of a novel phoxim nanoemulsion pesticide against Spodoptera litura - Zong-Nan Li; Yu-Xuan Zhang; Zhi-Ang Zhang; Lian-Han Pan; Ping Li; Yan Xu; Sheng Sheng; Fu-An Wu; Jun Wang (Environmental Science and Pollution Research, 2022)

Nature-based solutions for securing contributions of water, food, and energy in an urban environment - Mei-Hua Yuan; Fang-Chen Lo; Chang-Ping Yu; Hsin-hsin Tung; Yu-Sen Chang; Pei-Te Chiueh; Hsin-Chieh; Huang; Chao-Chin Chang; Chung-Yu Guan; Chun-Wei Wu; Zi-Xuan Xu; et al. (Environmental Science and Pollution Research, 2022)

Hydrogen sulfide supplement preserves mitochondrial function of retinal ganglion cell in a rat glaucoma model - Shouyue Huang; Ping Huang; Huan Yu; Junjue Chen; Xiaohong Liu; Jing Wang; Xi Shen; Yisheng Zhong (Cell and Tissue Research, 2022)

Fertility conversion between cytoplasmic maintainer lines and restorer lines through molecular marker-assisted selection in pepper (Capsicum annuum L.) - Fu-Sen Ren; Hai-Feng Yang; Yu-Shun Jiao; Rui-Ping Zhang; Zhi-Wei Guo; He-Juan Liu; Qiang Sun; Xi-Jun Li; Xiu-Fang Tan; Bei Zhang; Jun-Qi Zhen; Yan-Qi Dong (Biologia, 2022)

Sphingopyxis yananensis sp. nov., a novel 2-nitropropane degrading bacterium isolated from a microbial fermentation bed substrate - Chao-chao Zheng; Ying-ying Jiang; Tian-fei Yu; Jing Li; Jia-min Ai; Mai-ping Li; Xiao-dong Liu; Zhen-shan Deng (Archives of Microbiology, 2022)

The effects of dietary fermented wheat bran polysaccharides on mucosal and serum immune parameters, hepatopancreas antioxidant indicators, and immune-related gene expression of common carp (Cyprinus carpio) juveniles - Rui-Fang Wang; Yuan Wang; Jun Zhang; Mei-Qi Weng; Yu-Hui Liu; Qiu-Yan Cheng; Min Song; Yan-Ping Yang; Xiao-Ping An; Jing-Wei Qi (Aquaculture International, 2022)

Instability and Failure of Subsea Structures - Fu-Ping Gao; Zhen-Yu Yin (Journal of Marine Science and Engineering, 2022)
Subsea engineering structures are an evolutive system with high diversity, e [...]

Belowground processes and sustainability in agroecosystems with intercropping - Rui-Peng Yu; Hao Yang; Yi Xing; Wei-Ping Zhang; Hans Lambers; Long Li (Plant and Soil, 2022)

Correction to: Exercise Rehabilitation and/or Astragaloside Attenuate Amyloid-beta Pathology by Reversing BDNF/TrkB Signaling Deficits and Mitochondrial Dysfunction - Yu-Lin Wang; Chung-Ching Chio; Shu-Chun Kuo; Chao-Hung Yeh; Jui-Ti Ma; Wen-Pin Liu; Mao-Tsun Lin; Kao-Chang Lin; Ching-Ping Chang (Molecular Neurobiology, 2022)

Effect of mixed inhibitor application on N2O production pathways in paddy soil - Kaikuo Wu; Ping Gong; Wei Bai; Zhe Zhang; Zhanbo Wei; Chunxiao Yu; Yuchao Song; Yan Xue; Lili Zhang (Journal of Soils and Sediments, 2022)

Rhodoflexus caldus gen. nov., sp. nov., a new member of the phylum Bacteroidota isolated from a hot spring sediment - Ze-Tao Liu; Lan Liu; Wen-Dong Xian; Zheng-Han Lian; Jun-Yi Dai; Bao-Zhu Fang; Meng-Meng Li; Ai-Ping Lv; Zhen-Hao Luo; Jian-Yu Jiao; Wen-Jun Li (Antonie van Leeuwenhoek, 2022)

Cadinane-type sesquiterpenes with potential anti-inflammatory and anti-HIV activities from the stems and leaves of Mappianthus iodoides - Yan-Ping Liu; Xiao-Mei Yu; Ze-Hua Qiao; Bo Jiang; Lan Xie; Hao-Xuan Tang; Xiao Liang; Yan-Hui Fu (Natural Product Research, 2022)

CD146 as a promising therapeutic target for retinal and choroidal neovascularization diseases - Bai Xue; Ping Wang; Wenzhen Yu; Jing Feng; Jie Li; Rulian Zhao; Zhenglin Yang; Xiyun Yan; Hongxia Duan (Science China Life Sciences, 2022)

Field Study of Compaction Quality Control Parameters and Compaction Mechanism of Large Particle Size Stone-filled Embankment - Ping Xu; Xiong Zhu; Shifan Qiao; Gang Wang; Pengkun Yu (Rock Mechanics and Rock Engineering, 2022)

CaMKIIα Signaling Is Required for the Neuroprotective Effects of Dl-3-n-Butylphthalide in Alzheimer’s Disease - Bing-qiu Li; Ling-zhi Xu; Fang-yu Li; Ying Li; Yu Zhao; Heng Zhang; Mei-na Quan; Jian-ping Jia (Molecular Neurobiology, 2022)

Regulation of wound healing and fibrosis by galectins - Dong Yu; Ming Bu; Ping Yu; Yaping Li; Yang Chong (Journal of Molecular Medicine, 2022)

Breast Cancer Awareness Based on Health Information Literacy and Influential Factors among Female Nursing Students in China - Shu Yang; Ping Li; Lin Yu; Na Liu; Jie Wang; Pingping Guo; Xuehui Zhang; Wei Zhang (Journal of Cancer Education, 2022)

A20 attenuates pyroptosis and apoptosis in nucleus pulposus cells via promoting mitophagy and stabilizing mitochondrial dynamics - Xin Peng; Cong Zhang; Zhi-Min Zhou; Kun Wang; Jia-Wei Gao; Zhan-Yang Qian; Jun-Ping Bao; Hang-Yu Ji; V. L. F. Cabral; Xiao-Tao Wu (Inflammation Research, 2022)

Rapid triage for ischemic stroke: a machine learning-driven approach in the context of predictive, preventive and personalised medicine - Yulu Zheng; Zheng Guo; Yanbo Zhang; Jianjing Shang; Leilei Yu; Ping Fu; Yizhi Liu; Xingang Li; Hao Wang; Ling Ren; Wei Zhang; Haifeng Hou; et al. (EPMA Journal, 2022)
Background Recognising the early signs of ischemic stroke (IS) in emergency settings has been challenging. Machine learning (ML), a robust tool for predictive, preventive and personalised medicine (PPPM/3PM), presents a possible solution for this issue and produces accurate predictions for real-time data processing. Methods This investigation evaluated 4999 IS patients among a total of 10,476 adults included in the initial dataset, and 1076 IS subjects among 3935 participants in the external validation dataset. Six ML-based models for the prediction of IS were trained on the initial dataset of 10,476 participants (split participants into a training set [80%] and an internal validation set [20%]). Selected clinical laboratory features routinely assessed at admission were used to inform the models. Model performance was mainly evaluated by the area under the receiver operating characteristic (AUC) curve. Additional techniques—permutation feature importance (PFI), local interpretable model-agnostic explanations (LIME), and SHapley Additive exPlanations (SHAP)—were applied for explaining the black-box ML models. Results Fifteen routine haematological and biochemical features were selected to establish ML-based models for the prediction of IS. The XGBoost-based model achieved the highest predictive performance, reaching AUCs of 0.91 (0.90–0.92) and 0.92 (0.91–0.93) in the internal and external datasets respectively. PFI globally revealed that demographic feature age, routine haematological parameters, haemoglobin and neutrophil count, and biochemical analytes total protein and high-density lipoprotein cholesterol were more influential on the model’s prediction. LIME and SHAP showed similar local feature attribution explanations. Conclusion In the context of PPPM/3PM, we used the selected predictors obtained from the results of common blood tests to develop and validate ML-based models for the diagnosis of IS. The XGBoost-based model offers the most accurate prediction. By incorporating the individualised patient profile, this prediction tool is simple and quick to administer. This is promising to support subjective decision making in resource-limited settings or primary care, thereby shortening the time window for the treatment, and improving outcomes after IS.

Astragalus Polysaccharides Reduce High-glucose-induced Rat Aortic Endothelial Cell Senescence and Inflammasome Activation by Modulating the Mitochondrial Na+/Ca2+ Exchanger - Xin-Yu Miao; Xiao-Xiao Zhu; Zhao-Yan Gu; Bo Fu; Shao-Yuan Cui; Yuan Zu; Ling-Jun Rong; Fan Hu; Xiang-Mei Chen; Yan-Ping Gong; Chun-Lin Li (Cell Biochemistry and Biophysics, 2022)

Preliminary study of genome-wide association identifies novel susceptibility genes for serum mineral elements in the Chinese Han population - Duojian Guo; Yu Zhou; Xingwei Wei; Shanshan Zhang; Tianbo Jin; Yutian Zhang; Mei Lin; Xiaoli Zhou; Yufei Xie; Chanyi He; Qi Lin; Ping He; et al. (Biological Trace Element Research, 2022)

A critical review on EDTA washing in soil remediation for potentially toxic elements (PTEs) pollutants - Yaoning Chen; Hongjuan Jiang; Yuanping Li; Yihuan Liu; Yanrong Chen; Li Chen; Xinli Luo; Ping Tang; Haoqin Yan; Mengyang Zhao; Yu Yuan; Suzhen Hou (Reviews in Environmental Science and Bio/Technology, 2022)

Investigation on long-term progressive deformation of engineering slope based on comprehensive monitoring - Shi-shu Zhang; Song-feng Guo; Sheng-wen Qi; Feng-jiao Tang; Jin-shan Hu; Xiao-ping Zhao; Cong-yan Ran; Xin Wang; Yu Zou; Xiao-lin Huang; Bo-wen Zheng; Ning Liang (Journal of Mountain Science, 2022)

Effective in vitro culture using dormant bud of nodal sections from a mature Acacia tree - Wai-Jane Ho; Yu-Kai Huang; Wen-Wen Huang; Yu-Chen Huang; Jen-Ping Chung (In Vitro Cellular & Developmental Biology - Plant, 2022)

Qipengyuania thermophila sp. nov., isolated from a Chinese hot spring - Zi-Yu Zhao; Ting-Ting Xia; Jian-Yu Jiao; Lan Liu; Qing-Yang Su; Meng-Meng Li; Ai-Ping Lv; Yu-Ting Ouyang; Wen-Jun Li; Hong Ming (Archives of Microbiology, 2022)

Wavefield reconstruction inversion with weak-total-variation constraint based on first arrival traveltime tomography - Shao-Shun Zhang; Jian-Ping Huang; Zhen-Yu Wang (Applied Geophysics, 2022)

SLOSS ‐based inferences in a fragmented landscape depend on fragment area and species–area slope - Jinliang Liu; Zachary G. MacDonald; Xingfeng Si; Lingbing Wu; Di Zeng; Guang Hu; Ping Ding; Mingjian Yu (Journal of Biogeography, 2022)
Aims Whether a Single Large Or Several Small (SLOSS) habitat patches contain more species is central to the debate about how habitat fragmentation threatens species diversity. However, the geographical and biogeographical variables that affect emergent SLOSS patterns remain poorly understood. Here, we quantified SLOSS‐based diversity patterns of woody plant, bird and spider assemblages in a subtropical archipelago of land bridge islands. Location Thousand Island Lake, Zhejiang Province, China. Taxon Woody plants, birds and spiders. Methods We analysed species accumulation curves and species–area relationships (SARs) to quantify SLOSS‐based patterns of all, common and rare species for each taxon across different groupings of islands. Differences in the number of species between a single large island and sets of several small islands were measured in these analyses using a Saturation index (SI) and SLOSS index. Generalized additive models were used to assess the relationships between SI and SLOSS index values and the maximum area of islands included in the analysis, the slope of SARs (i.e. z ‐score) and the degree of nestedness. Results SI values increased with the maximum area of islands for three taxa, while SLOSS index values only increased with the maximum island area for woody plants. SI values increased as z ‐scores of woody plants decreased, and showed a quadratic relationship for birds and spiders. SLOSS index values decreased as z ‐scores of three taxa increased. The degree of nestedness and SI values or SLOSS index values were weakly correlated with all, rare and common species in the three taxa. Main conclusions SLOSS‐based inferences of fragmentation effects are contingent on variation in the maximum area of patches included in analyses and the slope of SARs in fragmentated landscapes. Whether conservation efforts should prioritize a single large or several small patches depends on the geographical (e.g. maximum fragment area) and biogeographical (e.g. slope of SAR) attributes of a fragmentated landscape.

A landscape‐level analysis of bird taxonomic, functional and phylogenetic β‐diversity in habitat island systems - Chi Zeng; Wande Li; Ping Ding; Yu Peng; Lingbing Wu; Xingfeng Si (Journal of Biogeography, 2022)
Aim How β‐diversity patterns are shaped by landscape‐level processes remains unclear across habitat island systems. Here we assessed landscape‐level bird β‐diversity in habitat island systems and aimed to (1) evaluate the relative contribution of turnover (β SIM ) and nestedness‐resultant (β SNE ) components to multisite β‐diversity (β SOR ) from taxonomic, functional and phylogenetic dimensions; (2) examine the influence of climate factors and system characteristics in shaping landscape‐level patterns of β‐diversity measures; and (3) study how β‐diversity patterns of bird communities vary with the spatial extents of island systems. Location Global. Taxon Birds. Methods We compiled bird data in 22 habitat island systems from literature and classified these island systems into small and large spatial scales. We partitioned β SOR into β SIM and β SNE from three dimensions for each system and calculated standardized functional and phylogenetic β‐diversity measures. We assessed the effects of climate factors and system characteristics on observed and standardized β‐diversity measures by multiple linear models for both small and large systems. Results We found that the dominant role of β SIM to β SOR in habitat island systems was pervasive. However, the best explanatory variables were not consistent across systems, which depended on the β‐diversity components, diversity dimensions and spatial extent of habitat island systems. In general, climate factors acted as the main drivers of bird communities across small and large systems, whereas system characteristics played minor roles. Main conclusions Spatial turnover dominated overall bird β‐diversity in most habitat island systems. Our results imply the roles of niche‐based assembly processes through the interplay among differential functional traits and phylogenetic distances of species, climate factors and system characteristics as well as spatial extent in driving bird communities across multiple habitat island systems at a landscape level. This study offers a better understanding of the processes underlying macroecological patterns of isolated biological communities across habitat island systems.

Episodic Neoproterozoic extension-related magmatism in the Altyn Tagh, NW China: implications for extension and breakup processes of Rodinia supercontinent - Jiang-bo Hao; Chao Wang; Ji-heng Zhang; Liang Liu; Yong-sheng Gai; Hang Li; Zun-pu Yu; Joseph G Meert; Xiao-ping Long; Xiao-kui Sun; Shuai Zhang (International Geology Review, 2022)

Prenylated coumarins from the fruits of Artocarpus heterophyllus with their potential anti-inflammatory and anti-HIV activities - Lei Tao; Ya-Ting Zhuo; Ze-Hua Qiao; Juan Li; Hao-Xuan Tang; Qiao-Mei Yu; Yun-Yao Liu; Yan-Ping Liu (Natural Product Research, 2022)

One new piperazinedione isolated from a mangrove-derived fungus Aspergillus niger JX-5 - Meng Bai; Yue Wang; Ting Liu; Yu-Xing Lian; Qi-Qi Bai; Xiao-Ping Song; Chang-Ri Han; Cai-Juan Zheng; Guang-Ying Chen (Natural Product Research, 2022)

Diverse grouping and mating strategies in the Critically Endangered Hainan gibbon (Nomascus hainanus) - Ping Li; Paul A. Garber; Yu Bi; Kun Jin; Xuming Qi; Jiang Zhou (Primates, 2022)
Understanding flexibility in the social structure and mating strategies of the world’s last remaining population (35 individuals) of wild Hainan gibbons ( Nomascus hainanus ) is critical for developing effective management plans to aid in their population recovery. Three of the five remaining Hainan gibbon groups (A, B, and C) currently live in a social unit characterized by two or three adult males, two reproducing adult females, and offspring. A fourth group (D) contains one adult male, two adult females, and offspring, and Group E contains a single adult male–adult female pair with a young infant. In this study, we describe observations of copulations between multiple resident males and one of the two resident females in Group C. Group C is best described as a small multi-male/multi-female group. We found that this breeding female (F2) solicited copulations from two resident adult males (M1 and M2) on the same day, and also mated with each of these two males on different days. Resident males were not observed to interrupt the mating pair. Although factors such as a biased adult sex ratio, severe population disruption, and habitat degradation can help explain variation in group composition and mating strategies in Hainan gibbons, we argue that there exists considerable mating system variability across gibbon species, and that this variability offers important insights into male and female Hainan gibbon group structure and reproductive strategies.

Mutation of Beclin1 acetylation site at K414 alleviates high glucose-induced podocyte impairment in the early stage of diabetic nephropathy by inhibiting hyperactivated autophagy - Jun Xu; Yujie Deng; Yingying Ke; Yunxia Zhu; Ping Wang; Qing Yu; Chengqian Li; Bimin Shi (Molecular Biology Reports, 2022)

Effects of Involuntary and Voluntary Exercise in Combination with Acousto-Optic Stimulation on Adult Neurogenesis in an Alzheimer's Mouse Model - Wan-yi Li; Jun-yan Gao; Su-Yang Lin; Shao-tao Pan; Biao Xiao; Yu-tao Ma; Kai Xie; Wei Shen; Zhi-tao Liu; Guang-yu Li; Jie-jie Guo; Qin-wen Wang; et al. (Molecular Neurobiology, 2022)

Exercise Rehabilitation and/or Astragaloside Attenuate Amyloid-beta Pathology by Reversing BDNF/TrkB Signaling Deficits and Mitochondrial Dysfunction - Yu-Lin Wang; Chung-Ching Chio; Shu-Chun Kuo; Chao-Hung Yeh; Jui-Ti Ma; Wen-Pin Liu; Mao-Tsun Lin; Kao-Chang Lin; Ching-Ping Chang (Molecular Neurobiology, 2022)

Response of xenobiotic biodegradation and metabolic genes in Tribolium castaneum following eugenol exposure - Yonglei Zhang; Shanshan Gao; Ping Zhang; Haidi Sun; Ruixue Lu; Runnan Yu; Yanxiao Li; Kunpeng Zhang; Bin Li (Molecular Genetics and Genomics, 2022)

The Effects of Ground and Treadmill Running on Energy Metabolism and Muscle Contractile Properties: A Randomized Cross-Over Study - Yuan Zhou; Jian-gang Chen; Xiao-long Li; Xin-liang Pan; Yi-zheng Zhou; Zheng-ao Li; Zhi-cheng Liang; Jia-min Long; Ming-ze Qin; Jing Zhang; Bing Shi; Bing-jun Wan; et al. (Journal of Science in Sport and Exercise, 2022)
Purpose This study aimed to compare the effects of ground and treadmill running on energy metabolism and muscle contractile properties, providing a basis for the general public to choose running venues. Methods Ten male college students (age, 20.10 ± 1.53 years; height, 176.20 ± 5.49 cm; weight, 72.14 ± 8.25 kg; body fat percent, 12.41% ± 4.65%) were recruited in this study. Energy expenditure (EE) was measured using the accelerometer (GT9X) combined with specific estimation equations. Average heart rate (HR) was measured using a heart rate band (Polar). Muscle contractile properties were assessed by measuring muscle displacement (Dm) and contraction velocity (Vc) using tensiomyography (TMG-S1). Blood glucose (Glu) and lactate (Lac) were measured by portable devices (eB-G and Lactate Scout). The running speed was 9 km/h and the duration was 25 min. Two-way ANOVA (protocol × time) was used to analyze the effect of running protocols on energy metabolism and muscle contractile properties. Results EE of treadmill running was significantly higher than EE of ground running (protocol main effect, P < 0.001), and HR of treadmill running was significantly higher than that of ground running in the first testing time (protocol simple effect, P = 0.026; protocol × time interaction P = 0.043). The decrease in Dm of the rectus femoris after treadmill running was significantly higher than that of ground running (protocol main effect, P = 0.009). The interaction of different running protocols and testing times on Lac was significant ( P = 0.025), but all results of the simple effects analysis were not statistically significant ( P > 0.05). Conclusion Our study found a difference in energy expenditure between treadmill and ground running at 9 km/h with duration of 25 min. In addition, treadmills are more likely to cause a decrease in muscle displacement distance of the rectus femoris measured after exercise than ground running. Future studies are needed to further investigate whether the differences are induced by internal metabolism or the environmental conditions of running.

Comparative transcriptomics and multiple phytohormone profiling reveals the molecular immune response of Arabidopsis thaliana to the pathogen Ralstonia solanacearum type III effector RipN - Zhangyong Dong; Xiaoying Zheng; Yongxin Shu; Zhen Meng; Jie Zhang; Lina Xiong; Ping Cheng; Guohui Yu; Yunhao Sun (Journal of Plant Pathology, 2022)

TREM2 and CD163 Ameliorate Microglia-Mediated Inflammatory Environment in the Aging Brain - Xue Han; Yu-Jia Liu; Bin-Wen Liu; Zheng-Liang Ma; Tian-Jiao Xia; Xiao-Ping Gu (Journal of Molecular Neuroscience, 2022)

Residential proximity to major roadway and progression in physical disability in older adults in China - Jing Hu; Wenqian Chen; Lei Li; Yu Zhang; Hongwei Jiang; Wenhua Liu; Ping Yin (Environmental Science and Pollution Research, 2022)

Psychroserpens luteolus sp. nov., isolated from Gelidium, reclassification of Ichthyenterobacterium magnum as Psychroserpens magnus comb. nov., Flavihalobacter algicola as Psychroserpens algicola comb. nov., Arcticiflavibacter luteus as Psychroserpens luteus comb. nov - Xiu-Ya Ping; Kai Wang; Jin-Yu Zhang; Shu-Xin Wang; Zong-Jun Du; Da-Shuai Mu (Archives of Microbiology, 2022)

Geochronological, geochemical, and P–T path constraints on the late Paleoproterozoic continent–continent collision orogeny in the Quruqtagh Block, Tarim Craton - Tao Cui; Shan-Shan Li; Rui-Qing Guo; Germain Bishikwabo; Xiang-Kuan Gong; Gui-Ping Liu; Yu Guo (Arabian Journal of Geosciences, 2022)

Genome-based reclassification of the genus Meiothermus along with the proposal of a new genus Allomeiothermus gen. nov - Jian-Yu Jiao; Zheng-Han Lian; Ze-Tao Liu; Lan Liu; Meng-Meng Li; Ai-Ping Lv; Wen-Dong Xian; Ting Zhou; Zhitang Lyu; Nimaichand Salam; Wen-Jun Li (Antonie van Leeuwenhoek, 2022)

Evaluation of red-edge features for identifying subtropical tree species based on Sentinel-2 and Gaofen-6 time series - Wanwan Yu; Ping Zhao; Kaijian Xu; Yuejiao Zhao; Pengju Shen; Jingjing Ma (International Journal of Remote Sensing, 2022)

Dissection of the practical soybean breeding pipeline by developing ZDX1, a high-throughput functional array - Rujian Sun; Bincheng Sun; Yu Tian; Shanshan Su; Yong Zhang; Wanhai Zhang; Jingshun Wang; Ping Yu; Bingfu Guo; Huihui Li; Yanfei Li; Huawei Gao; et al. (Theoretical and Applied Genetics, 2022)
Key message We developed the ZDX1 high-throughput functional soybean array for high accuracy evaluation and selection of both parents and progeny, which can greatly accelerate soybean breeding. Abstract Microarray technology facilitates rapid, accurate, and economical genotyping. Here, using resequencing data from 2214 representative soybean accessions, we developed the high-throughput functional array ZDX1, containing 158,959 SNPs, covering 90.92% of soybean genes and sites related to important traits. By application of the array, a total of 817 accessions were genotyped, including three subpopulations of candidate parental lines, parental lines and their progeny from practical breeding. The fixed SNPs were identified in progeny, indicating artificial selection during the breeding process. By identifying functional sites of target traits, novel soybean cyst nematode-resistant progeny and maturity-related novel sources were identified by allele combinations, demonstrating that functional sites provide an efficient method for the rapid screening of desirable traits or gene sources. Notably, we found that the breeding index (BI) was a good indicator for progeny selection. Superior progeny were derived from the combination of distantly related parents, with at least one parent having a higher BI. Furthermore, new combinations based on good performance were proposed for further breeding after excluding redundant and closely related parents. Genomic best linear unbiased prediction (GBLUP) analysis was the best analysis method and achieved the highest accuracy in predicting four traits when comparing SNPs in genic regions rather than whole genomic or intergenic SNPs. The prediction accuracy was improved by 32.1% by using progeny to expand the training population. Collectively, a versatile assay demonstrated that the functional ZDX1 array provided efficient information for the design and optimization of a breeding pipeline for accelerated soybean breeding.

Curcumin Inhibits Cell Damage and Apoptosis Caused by Thapsigargin-Induced Endoplasmic Reticulum Stress Involving the Recovery of Mitochondrial Function Mediated by Mitofusin-2 - He-Yan Zhou; Yu-Ying Sun; Ping Chang; Han-Chang Huang (Neurotoxicity Research, 2022)

Involvement of Opioid Peptides in the Analgesic Effect of Spinal Cord Stimulation in a Rat Model of Neuropathic Pain - Fu-Jun Zhai; Song-Ping Han; Tian-Jia Song; Ran Huo; Xing-Yu Lan; Rong Zhang; Ji-Sheng Han (Neuroscience Bulletin, 2022)

Anterior Cingulate Cortex Mediates Hyperalgesia and Anxiety Induced by Chronic Pancreatitis in Rats - Dan Ren; Jia-Ni Li; Xin-Tong Qiu; Fa-Ping Wan; Zhen-Yu Wu; Bo-Yuan Fan; Ming-Ming Zhang; Tao Chen; Hui Li; Yang Bai; Yun-Qing Li (Neuroscience Bulletin, 2022)
Central sensitization is essential in maintaining chronic pain induced by chronic pancreatitis (CP), but cortical modulation of painful CP remains elusive. Here, we examined the role of the anterior cingulate cortex (ACC) in the pathogenesis of abdominal hyperalgesia in a rat model of CP induced by intraductal administration of trinitrobenzene sulfonic acid (TNBS). TNBS treatment resulted in long-term abdominal hyperalgesia and anxiety in rats. Morphological data indicated that painful CP induced a significant increase in FOS-expressing neurons in the nucleus tractus solitarii (NTS) and ACC, and some FOS-expressing neurons in the NTS projected to the ACC. In addition, a larger portion of ascending fibers from the NTS innervated pyramidal neurons, the neural subpopulation primarily expressing FOS under the condition of painful CP, rather than GABAergic neurons within the ACC. CP rats showed increased expression of vesicular glutamate transporter 1, and increased membrane trafficking and phosphorylation of the N -methyl-D-aspartate receptor (NMDAR) subunit NR2B and the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) subunit GluR1 within the ACC. Microinjection of NMDAR and AMPAR antagonists into the ACC to block excitatory synaptic transmission significantly attenuated abdominal hyperalgesia in CP rats, which was similar to the analgesic effect of endomorphins injected into the ACC. Specifically inhibiting the excitability of ACC pyramidal cells via chemogenetics reduced both hyperalgesia and comorbid anxiety, whereas activating these neurons via optogenetics failed to aggravate hyperalgesia and anxiety in CP rats. Taken together, these findings provide neurocircuit, biochemical, and behavioral evidence for involvement of the ACC in hyperalgesia and anxiety in CP rats, as well as novel insights into the cortical modulation of painful CP, and highlights the ACC as a potential target for neuromodulatory interventions in the treatment of painful CP.

Association between congenital heart defects and maternal manganese and iron concentrations: a case–control study in China - Meixian Wang; Yan Tian; Ping Yu; Nana Li; Ying Deng; Lu Li; Hong Kang; Dapeng Chen; Hui Wang; Zhen Liu; Juan Liang (Environmental Science and Pollution Research, 2022)
To investigate the correlation between maternal manganese and iron concentrations and the risk of CHD among their infant. A multi-center hospital-based case control study was conducted in China. There were 322 cases and 333 controls have been selected from pregnant women who received prenatal examinations. Correlations between CHDs and maternal manganese and iron concentrations were estimated by conditional logistic regression. Moreover, the interaction between manganese and iron on CHDs was analyzed. Compared with the controls, mothers whose hair manganese concentration was 3.01 μg/g or more were more likely to have a child with CHD than those with a lower concentration. The adjusted OR was 2.68 (95%CI = 1.44–4.99). The results suggested that mothers whose iron content was 52.95 μg/g or more had a significantly higher risk of having a child with CHD ( aOR = 2.87, 95%CI = 1.54–5.37). No interaction between maternal manganese and iron concentrations was observed in the multiplicative or additive model. The concurrently existing high concentration of manganese and iron may bring higher risk of CHD ( OR = 7.02). Women with excessive manganese concentrations have a significantly increased risk of having offspring with CHDs. The high maternal iron status also correlates with CHDs. The concurrently existing high concentration of manganese and iron may bring higher risk of CHD.

Stability properties of natural estrogen conjugates in different aqueous samples at room temperature and tips for sample storage - Jun Zhang; Yi-ping Wan; Ze-hua Liu; Hao Wang; Zhi Dang; Yu Liu (Environmental Science and Pollution Research, 2022)

Expression of l-phosphinothricin synthesis enzymes in Pichia pastoris for synthesis of l-phosphinothricin - Yu-Ke Cen; Qi Wang; Huo Gong; Ya-Ping Xue; Yu-Guo Zheng (Biotechnology Letters, 2022)

Complete genome analysis of a novel picorna-like virus from a ladybird beetle (Cheilomenes sexmaculata) - Yu-Juan He; Zhuang-Xin Ye; Jian-Ping Chen; Chuan-Xi Zhang; Gang Lu; Jun-Min Li (Archives of Virology, 2022)

Air-Sea Latent Heat Flux Anomalies Induced by Oceanic Submesoscale Processes: An Observational Case Study - Xiangzhou Song; Xuehan Xie; Bo Qiu; Haijin Cao; Shang-Ping Xie; Zhiqiang Chen; Weidong Yu (Frontiers in Marine Science, 2022)
The classical theory predicts that a geostrophically balanced mesoscale eddy can cause a sea surface temperature (SST) anomaly related to Ekman pumping. Previous studies show that an eddy-induced SST anomaly can result in a sea surface latent heat flux (LH) anomaly at a maximum magnitude of ∼ O (10) Wm –2 , decaying radially outward from the center to the margin. In this study, we investigate the LH anomalies associated with submesoscale processes within a cyclonic eddy for the first time using recent satellite-ship-coordinated air-sea observations in the South China Sea. Unbalanced submesoscale features can be identified as submesoscale SST fronts. Along the ship track, the SST strikingly decreases by 0.5°C within a horizontal distance of ∼1.5 km and increases quickly by 0.9°C with a spatial interval of ∼3.6 km. The along-track SST is decomposed into three parts: large-scale south-north fronts and anomalies induced by mesoscale and submesoscale motions. Our analysis shows that the amplitude of the LH anomaly induced by the mesoscale SST anomaly is 12.3 Wm –2 , while it is 14.3 Wm –2 by unbalanced submesoscale motions. The mean (maximum) spatial gradient of the submesoscale LH anomalies is 1.7 (75.7) Wm –2 km –1 , which is approximately 1.5 times those (1.2 and 59.9 Wm –2 km –1 ) in association with mesoscale eddies. The spectra of LH and SST anomalies show similar peaks at ∼15 km before sloping down with a power law between k –2 and k –3 , indicating the underlying relationship between the LH variance and submesoscale processes.

New sesquiterpeniod esters form Blumea balsamifera (L.) DC. and their anti-influenza virus activity - Yan Xiong; Ping Yi; Yuhuan Li; Rongmei Gao; Junlei Chen; Zhanxing Hu; Huayong Lou; Caixia Du; Jiayu Zhang; Yu Zhang; Chunmao Yuan; Liejun Huang; et al. (Natural Product Research, 2022)

Engineering laboratory/factory-specific phage-resistant strains of Escherichia coli by mutagenesis and screening - Qi Shen; Xiao-Ting Zhou; Qian Guo; Ya-Ping Xue; Yu-Guo Zheng (World Journal of Microbiology and Biotechnology, 2022)

Hippocampal SIRT1-Mediated Synaptic Plasticity and Glutamatergic Neuronal Excitability Are Involved in Prolonged Cognitive Dysfunction of Neonatal Rats Exposed to Propofol - Lin-Hui Ma; Jie Wan; Jing Yan; Ning Wang; Yan-Ping Liu; Hai-Bi Wang; Cheng-Hua Zhou; Yu-Qing Wu (Molecular Neurobiology, 2022)

Fate of heavy metals and bacterial community composition following biogas slurry application in a single rice cropping system - Qiang Wang; Zhaoming Chen; Jun Zhao; Junwei Ma; Qiaogang Yu; Ping Zou; Hui Lin; Jinchuan Ma (Journal of Soils and Sediments, 2022)

Analysis of Influencing Factors of Temperature Field in Freezing Construction of Metro Connecting Passage - Ping Xu; Shuqi Han; Yu Xing (Geotechnical and Geological Engineering, 2022)

Biological monitoring and health assessment of 21 metal(loid)s in children and adolescents in Liuzhou City, Southwest China - Yaping Li; Yu Zhang; Meng Yu; Liqin Hu; Ting Zeng; Ling Liu; Limei Wang; Liangqiong Deng; Xiang Li; Ping Liu; Dingyuan Zeng; Surong Mei (Environmental Science and Pollution Research, 2022)

Correlation assessment of NDVI and land use dynamics with water resources for the southern margin of Mu Us Sandy Land, China - Menglong Zhao; Yu Wang; Siyuan Liu; Ping-an Zhong; Hongzhen Liu; Rongrong Li (Environmental Science and Pollution Research, 2022)

Removal of SO2 from flue gas using blast furnace dust as an adsorbent - Binghua Xie; Na Geng; Qian Yu; Di He; Fang Wang; Tiancheng Liu; Jiyun Gao; Ping Ning; Xin Song; Lijuan Jia (Environmental Science and Pollution Research, 2022)

Is Zooplankton Body Size an Indicator of Water Quality in (Sub)tropical Reservoirs in China? - Li Wang; Jun Chen; Haojie Su; Xufa Ma; Zhixu Wu; Hong Shen; Jia Yu; Jiarui Liu; Yao Wu; Guangyi Ding; Ping Xie (Ecosystems, 2022)

Complete nucleotide sequence of a novel alphapartitivirus from Rhizoctonia solani AG-4 HG III isolate SM03 - Yanqiong Li; Wurong Chen; Yanfen Niu; Ping Xu; Lifang Zhang; Shuhui Yu; Genhua Yang; Xiaohan Mo (Archives of Virology, 2022)

Mitogenomic phylogeny resolves Cuneopsis (Bivalvia: Unionidae) as polyphyletic: The description of two new genera and a new species - Xiao‐Ping Wu; Yu‐Ting Dai; Nan Yin; Feng‐Yue Shu; Zhong‐Guang Chen; Liang Guo; Chun‐Hua Zhou; Shan Ouyang; Xiao‐Chen Huang (Zoologica Scripta, 2022)
Freshwater mussels are known to have two types of mitochondrial DNA (mtDNA) transmitted separately through oocytes and sperms, namely, maternal (F‐type) and paternal (M‐type) mtDNA. The additional suite of mitochondrial genes provides a great opportunity to resolve phylogenetically problematic relationships. East Asian freshwater mussels of the genus Cuneopsis were considered a compact group of taxa having wedge‐shaped shells. However, preliminary results from previous studies challenged the monophyly of Cuneopsis , and the exact phylogenetic relationships among Cuneopsis and its allied genera are yet to be determined with comprehensive species sampling. Here, we evaluated species boundaries in Cuneopsis based on COI barcoding and obtained 11 new F‐ and M‐type mitogenomes via genome skimming to elucidate the evolutionary history of Cuneopsis . COI barcode data supported the validity of all sampled six Cuneopsis species (missing C. kiangsiensis ). Our mitochondrial phylogenomic analyses confirmed that the currently recognized genus Cuneopsis sensu lato was polyphyletic, recovering three well‐supported clades. Molecular dating analysis suggested Cuneopsis s.l . diversified at ~58.06 million years ago in the Paleogene. Hereby, we propose two new genera, that is, Arcuneopsis gen. nov. and Pseudocuneopsis gen. nov. Additionally, we report a new species, Pseudocuneopsis sichuanensis sp. nov., from Chengdu, Sichuan, China, and a newly recorded species from China, Cuneopsis demangei .

MoOpy2 is essential for fungal development, pathogenicity, and autophagy in Magnaporthe oryzae - Ying‐Ying Cai; Jing‐Yi Wang; Xi‐Yu Wu; Shuang Liang; Xue‐Ming Zhu; Lin Li; Jian‐Ping Lu; Xiao‐Hong Liu; Fu‐Cheng Lin (Environmental Microbiology, 2022)
Summary The development and pathogenicity of the fungus Magnaporthe oryzae , the causal agent of destructive rice blast disease, require it to perceive external environmental signals. Opy2, an overproduction‐induced pheromone‐resistant protein 2, is a crucial protein for sensing external signals in Saccharomyces cerevisiae . However, the biological functions of the homologue of Opy2 in M. oryzae are unclear. In this study, we identified that MoOPY2 is involved in fungal development, pathogenicity, and autophagy in M. oryzae . Deletion of MoOPY2 resulted in pleiotropic defects in hyphal growth, conidiation, germ tube extension, appressorium formation, appressorium turgor generation, and invasive growth, therefore leading to attenuated pathogenicity. Furthermore, MoOpy2 participates in the Osm1 MAPK pathway and the Mps1 MAPK pathway by interacting with the adaptor protein Mst50. The interaction sites of Mst50 and MoOpy2 colocalized with the autophagic marker protein MoAtg8 in the preautophagosomal structure sites (PAS). Notably, the Δ Moopy2 mutant caused cumulative MoAtg8 lipidation and rapid GFP‐MoAtg8 degradation in response to nitrogen starvation, showing that MoOpy2 is involved in the negative regulation of autophagy activity. Taken together, our study revealed that MoOpy2 of M. oryzae plays an essential role in the orchestration of fungal development, appressorium penetration, autophagy and pathogenesis.

Endosomal sorting complexes required for transport‐0 ( ESCRT ‐0) are essential for fungal development, pathogenicity, autophagy and ER ‐phagy in Magnaporthe oryzae - Li‐Xiao Sun; Hui Qian; Meng‐Yu Liu; Ming‐Hua Wu; Yun‐Yun Wei; Xue‐Ming Zhu; Jian‐Ping Lu; Fu‐Cheng Lin; Xiao‐Hong Liu (Environmental Microbiology, 2022)
Summary Magnaporthe oryzae is an important plant pathogen that causes rice blast. Hse1 and Vps27 are components of ESCRT‐0 involved in the multivesicular body (MVB) sorting pathway and biogenesis. To date, the biological functions of ESCRT‐0 in M. oryzae have not been determined. In this study, we identified and characterized Hse1 and Vps27 in M. oryzae . Disruption of MoHse1 and MoVps27 caused pleiotropic defects in growth, conidiation, sexual development and pathogenicity, thereby resulting in loss of virulence in rice and barley leaves. Disruption of MoHse1 and MoVps27 triggered increased lipidation of MoAtg8 and degradation of GFP‐MoAtg8, indicating that ESCRT‐0 is involved in the regulation of autophagy. ESCRT‐0 was determined to interact with coat protein complex II (COPII), a regulator functioning in homeostasis of the endoplasmic reticulum (ER homeostasis), and disruption of MoHse1 and MoVps27 also blocked activation of the unfolded protein response (UPR) and autophagy of the endoplasmic reticulum (ER‐phagy). Overall, our results indicate that ESCRT‐0 plays critical roles in regulating fungal development, virulence, autophagy and ER‐phagy in M. oryzae .

Four new prenylflavonol glycosides from the leaves of Cyclocarya paliurus - Zi-Jun Ye; Hui-Hui Sun; Zu-Hui Chen; Jian-Ping Wu; Jing Li; Hui Zhu; Lu-Lu Huang; Xi-Wen Chang; Sai-Yu Ou; Wen-Xuan Wang; Xiao-Ai He; Gang-Zhi Zhu; et al. (Natural Product Research, 2022)

A framework for determining lowest navigable water levels with nonstationary characteristics - Lu Wang; Ping Xie; Chong-Yu Xu; Yan-Fang Sang; Jie Chen; Tao Yu (Stochastic Environmental Research and Risk Assessment, 2022)

Estimation of nitrogen status of paddy rice at vegetative phase using unmanned aerial vehicle based multispectral imagery - Yi-Ping Wang; Yu-Chieh Chang; Yuan Shen (Precision Agriculture, 2022)

Direct and indirect effects of precipitation change and nutrients addition on desert steppe productivity in Inner Mongolia, northern China - Xinxin Guo; Xiaoan Zuo; Ping Yue; Xiangyun Li; Ya Hu; Min Chen; Qiang Yu (Plant and Soil, 2022)

Mass cultivation of conidia of Pyricularia oryzae - Zhong-na Hao; Hai-ping Qiu; Zhen Zhang; Rong-yao Chai; Shi-zhen Wang; Yan-li Wang; Jiao-yu Wang; Guo-chang Sun (Journal of Plant Pathology, 2022)

Comparative Genomic Analysis of Streptococcus pneumoniae Strains: Penicillin Non-susceptible Multi-drug-Resistant Serotype 19A Isolates - Lifeng Li; Juanjuan Zhou; Mingchao Li; Zengyuan Yu; Kaijie Gao; Junwen Yang; Ping Cheng; Junmei Yang; Wancun Zhang; Zhidan Yu; Huiqing Sun (Current Microbiology, 2022)

The effect of bulk rock composition in phase equilibria modelling: a case study of mafic granulites from the North China Craton - Lei Zou; Jing-Hui Guo; Guang-Yu Huang; Shu-Juan Jiao; Zhong-Hua Tian; Ping-Hua Liu (Contributions to Mineralogy and Petrology, 2022)

Aberrant functional and effective connectivity of the frontostriatal network in unilateral acute tinnitus patients with hearing loss - Gang-Ping Zhou; Yu-Chen Chen; Wang-Wei Li; Heng-Le Wei; Yu-Sheng Yu; Qing-Qing Zhou; Xindao Yin; Yue-Jin Tao; Hong Zhang (Brain Imaging and Behavior, 2022)

Meta-analysis of Association Studies of Selenoprotein Gene Polymorphism and Kashin-Beck Disease: an Updated Systematic Review - Fang-fang Yu; Lei Sun; Guo-yu Zhou; Zhi-guang Ping; Xiong Guo; Yue Ba (Biological Trace Element Research, 2022)

Effect of freeze—thaw cycle on hydraulic conductivity of compacted clayey soil - Lei Guo; Qi-hao Yu; Na Yin; Dong-ming Zhang; Deng-ping Zhang; Xiu-ling Ren; Yan-hui You; Zhen-yu Zhang; Hui Bing; Shi-jie Chen (Journal of Mountain Science, 2022)

Bias‐corrections on aridity index simulations of climate models by observational constraints - Haipeng Yu; Qiang Zhang; Yun Wei; Chenxi Liu; Yu Ren; Ping Yue; Jie Zhou (International Journal of Climatology, 2022)
Aridity Index (AI) indicates the balance between water supply and water demand on the atmosphere–land interface. Despite continuous improvements, coupled climate models still have significant systematic errors in simulating AI in terms of temporal and spatial variabilities. One of the approaches to bias‐correct simulations is extracting the linear relationship between historical observations and model outputs by utilizing the empirical orthogonal function (EOF). In this study, the methodology of ensemble EOF‐based bias‐correction by observational constraints is developed based on previous bias‐correction approach, with the improvement on seeking the optimal combinations of the leading modes with sensitivity test and replacing the certain correction with the ensemble means of optimal members. In verification, the ensemble mean of Coupled Model Intercomparison Project phase 5 (CMIP5‐EM) is bias‐corrected towards the CPC/GLDAS observations, and the extracted leading modes present high correlations with internal climate variability. By cross‐validation and posteriori independent validation of hindcasts over the historical period (1948–2005), the ensemble EOF‐based bias‐correction could better present spatial patterns compared to the CMIP5‐EM after systematic bias‐correction, as indicated by the anomaly correlation and the root mean square error. The verifications also indicate that the temporal variability in aridity over different dryland regions is much closer to that in the observations and that the dryland subtype changes are improved significantly by bias‐corrections. Besides, another observational dataset of UDel/CRU is applied to assess the uncertainty on different datasets and the improvement on skill scores is robust. The above results verify that the ensemble EOF‐based bias‐corrections provide better reference for assessing and projecting global aridity changes by climate models.

Characterization of alkaloids in radix Sophora tonkinensis by UPLC-Q-TOF-MS/MS and its application in the comparison of two different habitats - Xing-Xing Zong; Yu Wang; Jia-Liang Xiong; Yu-Hui Ping; Qiong-Lin Liang (Natural Product Research, 2022)

Enhancing the production of physiologically active vitamin D3 by engineering the hydroxylase CYP105A1 and the electron transport chain - Bing Fu; Qian Ren; Jian Ma; Qingwei Chen; Qili Zhang; Ping Yu (World Journal of Microbiology and Biotechnology, 2022)

Association of Increased Amygdala Activity with Stress-Induced Anxiety but not Social Avoidance Behavior in Mice - Shou-He Huang; Wei-Zhu Liu; Xia Qin; Chen-Yi Guo; Qing-Cheng Xiong; Yu Wang; Ping Hu; Bing-Xing Pan; Wen-Hua Zhang (Neuroscience Bulletin, 2022)

A contribution to knowledge of Gyroporus (Gyroporaceae, Boletales) in China: three new taxa, two previous species, and one ambiguous taxon - Hui-Jing Xie; Li-Ping Tang; Man Mu; Yu-Guang Fan; Shuai Jiang; Ming-Sheng Su; Zhi-Qun Liang; Nian-Kai Zeng (Mycological Progress, 2022)

Correction to: MicroRNA-351 Promotes the Proliferation and Invasion of Glioma Cells Through Downregulation of NAIF1 - Xuanxuan Wu; Chongling Hu; Chunxi Long; Xuan Zhai; Ping Liang; Zengpeng Yu (Journal of Molecular Neuroscience, 2022)

Scalp Acupuncture Protects Against Neuronal Ferroptosis by Activating The p62-Keap1-Nrf2 Pathway in Rat Models of Intracranial Haemorrhage - Ming-Yue Li; Xiao-Hong Dai; Xue-Ping Yu; Wei Zou; Wei Teng; Peng Liu; Xin-Yang Yu; Qi An; Xin Wen (Journal of Molecular Neuroscience, 2022)
Intracerebral haemorrhage (ICH) can be a catastrophic event; even if the initial stages of the pathology were well-managed, a number of patients experience varied residual neurological deficits following the insult. Ferroptosis is a recently identified type of cell demise which is tightly linked to the neurological impairment associated with ICH. In the current work, the prophylactic impact of scalp acupuncture (SA) therapy on autologous blood injection murine models of ICH was investigated in order to establish whether SA could mitigate the secondary damage arising following ICH by moderating ferroptosis. The pathophysiological mechanisms associated with this process were also explored. Ludmila Belayev tests were utilised for the characterisation of neurological damage. Haematoxylin–eosin staining was employed in order to determine the cerebral impact of the induced ICH. Malondialdehyde (MDA) and iron titres in peri-haemorrhagic cerebral tissues were appraised using purchased assay kits. Transmission electron microscopy delineated mitochondrial appearances within nerve cell bodies from the area of haemorrhage. Western blotting techniques were utilised to assay the degree of protein expression of NeuN, sequestosome 1 (p62), nuclear factor erythroid 2-related factor 2 (Nrf2), Kelch-like ECH-associated protein 1 (Keap1), glutathione peroxidase 4 (GPX4) and ferritin heavy chain 1 (FTH1). The frequencies of Nrf2, GPX4 and FTH1 positive cells, respectively, were documented with immunohistochemical staining. The results demonstrated that therapy with SA after ICH mitigated MDA and iron sequestration, diminished the appearance of contracted mitochondria with increased outer mitochondrial membrane diameter within the nerve cell bodies, and suppressed neuronal ferroptosis. The pathways responsible for these effects may encompass amplified p62, Nrf2, GPX4 and FTH1 expression, together with decreased Keap1 expression. Application of SA reduced identified neurobehavioural abnormalities after ICH; no disparities were observed between the consequences of SA therapy and deferoxamine delivery. It can be surmised that intervention with SA enhanced recovery after ICH by triggering the antioxidant pathway, p62/Keap1/Nrf2, and causing FTH1 and GPX4 upregulation, factors that participate in diminishing excess iron and thus in mitigating lipid peroxidation insults arising from ferroptosis following ICH.

Laser ablation inductively coupled plasma mass spectrometry analysis of Chinese lead-barium glass: combining multivariate kernel density estimation and maximum mean discrepancy to reinterpret the raw glass used for producing lead-barium glass - Qian Ma; Rui Wen; Yifan Yu; Long Wang; Man Li; Luwu Cai; Li Ping; Zhiqiang Zhao; Dong Wang; Xiang Wang; Ruoyu Shi; A. Mark Pollard (Archaeological and Anthropological Sciences, 2022)

Biogeography of culturable marine bacteria from both poles reveals that ‘everything is not everywhere’ at the genomic level - Qi‐Long Qin; Zhi‐Bin Wang; Qian‐Qian Cha; Sha‐Sha Liu; Xue‐Bing Ren; Hui‐Hui Fu; Mei‐Ling Sun; Dian‐Li Zhao; Andrew McMinn; Yin Chen; Xiu‐Lan Chen; Yu‐Zhong Zhang; et al. (Environmental Microbiology, 2022)
Summary Based on 16S rRNA gene analyses, the same bacterial operational taxonomic units (OTUs) are common to both the Arctic and Antarctic oceans, supporting the concept ‘everything is everywhere’. However, whether the same OTUs from both poles have identical genomes, i.e. whether ‘everything is still everywhere’ at the genomic level has not yet been examined systematically. Here, we isolated, sequenced and compared the genomes of 45 culturable marine bacteria belonging to three genera of Salinibacterium , Psychrobacter and Pseudoalteromonas from both polar oceans. The bacterial strains with identical 16S rRNA genes were common to both poles in every genus, and four identical genomes were detected in the genus Salinibacterium from the Arctic region. However, no identical genomes were observed from opposite poles in this study. Our data, therefore, suggest that ‘everything is not everywhere’ at the genomic level. The divergence time between bacteria is hypothesized to exert a strong impact on the bacterial biogeography at the genomic level. The geographical isolation between poles was observed for recently diverged, highly similar genomes, but not for moderately similar genomes. This study thus improves our understanding of the factors affecting the genomic‐level biogeography of marine microorganisms isolated from distant locations.

Novel wing display and divergent agonistic behaviors of two incipient Psolodesmus damselflies - Leocris S. Batucan; Yu-Hsun Hsu; Jak W. Maliszewski; Liang-Jong Wang; Chung-Ping Lin (The Science of Nature, 2021)

Identification of New Transcription Factors that Can Promote Pluripotent Reprogramming - Ping Huang; Jieying Zhu; Yu Liu; Guihuan Liu; Ran Zhang; Dongwei Li; Duanqing Pei; Ping Zhu (Stem Cell Reviews and Reports, 2021)
Background Four transcription factors, Oct4, Sox2, Klf4, and c-Myc (the Yamanka factors), can reprogram somatic cells to induced pluripotent stem cells (iPSCs). Many studies have provided a number of alternative combinations to the non-Yamanaka factors. However, it is clear that many additional transcription factors that can generate iPSCs remain to be discovered. Methods The chromatin accessibility and transcriptional level of human embryonic stem cells and human urine cells were compared by Assay for Transposase-Accessible Chromatin with high-throughput sequencing (ATAC-seq) and RNA sequencing (RNA-seq) to identify potential reprogramming factors. Selected transcription factors were employed to reprogram urine cells, and the reprogramming efficiency was measured. Urine-derived iPSCs were detected for pluripotency by Immunofluorescence, quantitative polymerase chain reaction, RNA sequencing and teratoma formation test. Finally, we assessed the differentiation potential of the new iPSCs to cardiomyocytes in vitro. Results ATAC-seq and RNA-seq datasets predicted TEAD2, TEAD4 and ZIC3 as potential factors involved in urine cell reprogramming. Transfection of TEAD2, TEAD4 and ZIC3 (in the presence of Yamanaka factors) significantly improved the reprogramming efficiency of urine cells. We confirmed that the newly generated iPSCs possessed pluripotency characteristics similar to normal H1 embryonic stem cells. We also confirmed that the new iPSCs could differentiate to functional cardiomyocytes. Conclusions In conclusion, TEAD2, TEAD4 and ZIC3 can increase the efficiency of reprogramming human urine cells into iPSCs, and provides a new stem cell sources for the clinical application and modeling of cardiovascular disease. Graphical abstract

Recent advances in tissue stem cells - Xin Fu; Qiang He; Yu Tao; Mengdi Wang; Wei Wang; Yalong Wang; Qing Cissy Yu; Fang Zhang; Xiaoyu Zhang; Ye-Guang Chen; Dong Gao; Ping Hu; et al. (Science China Life Sciences, 2021)

Responses of ecosystem respiration, methane uptake and nitrous oxide emission to drought in a temperate desert steppe - Ping Yue; Xiaoan Zuo; Kaihui Li; Xiangyun Li; Shaokun Wang; Xujun Ma; Hao Qu; Min Chen; Liangxu Liu; Tom Misselbrook; Qiang Yu (Plant and Soil, 2021)

Deterioration Characteristics of Pre-flawed Granites Subjected to Freeze-Thaw Cycles and Compression - Chen Qiao; Yu Wang; Yong-jie Tong; He-ping Yang; Chang-hong Li; C. Qiao (Geotechnical and Geological Engineering, 2021)

Mercury uptake by Paspalum distichum L. in relation to the mercury distribution pattern in rhizosphere soil - Su Xu; Ping Gong; Wen Ding; Shengchun Wu; Xinwei Yu; Peng Liang (Environmental Science and Pollution Research, 2021)

Nitrogen contaminants damage on intestinal epithelial tight junctions: a review - Guo-ping Zhao; Jin-wang Li; Fang-wei Yang; Xiao-yu Wang; Fa-zheng Ren; Guo-fang Pang; Yi-xuan Li (Environmental Chemistry Letters, 2021)

Astaxanthin Ameliorates Blood Pressure in Salt-Induced Prehypertensive Rats Through ROS/MAPK/NF-κB Pathways in the Hypothalamic Paraventricular Nucleus - Hong-Li Gao; Xiao-Jing Yu; Yan Zhang; Chen-Long Wang; Yi-Ming Lei; Jia-Yue Yu; Dong-Miao Zong; Kai-Li Liu; Dong-Dong Zhang; Ying Li; Hua Tian; Nian-Ping Zhang; et al. (Cardiovascular Toxicology, 2021)

Biological synthesis of nicotinamide mononucleotide - Qi Shen; Shi-Jia Zhang; Yu-Zhen Xue; Feng Peng; Dong-Yuan Cheng; Ya-Ping Xue; Yu-Guo Zheng (Biotechnology Letters, 2021)

Triaxial mechanical properties and micro mechanism of fiber-modified cement soil - Yang Yao; Na Li; Haibo Kang; Wenjie Yu; Chen Zhang; Ping Jiang; Wei Wang (Arabian Journal of Geosciences, 2021)

Effects of replacing fishmeal with soybean protein concentrate (SPC) on growth, blood biochemical indexes, non-specific immune enzyme activity, and nutrient apparent digestibility for juvenile Litopenaeus vannamei - Zhan-Hao Zhu; Qi-hui Yang; Bei-ping Tan; Xiao-Qiu Zhou; Xiao-hui Dong; Shu-yan Chi; Hong-yu Liu; Shuang Zhang (Aquaculture International, 2021)

Synergistic inhibitory effect of berberine and icotinib on non-small cell lung cancer cells via inducing autophagic cell death and apoptosis - Ping Chen; Chun-Hua Dai; Zhi-Hao Shi; Yi Wang; Jian-Nong Wu; Kang Chen; Jin-Yu Su; Jian Li (Apoptosis, 2021)

The chemical profile and biological activity of different extracts of Sapindus mukorossi Gaertn. against Cutibacterium acnes - Min-Ping Wei; Jin-Dan Qiu; Lu Li; Yun-Fei Xie; Ya-Hui Guo; Hang Yu; Yu-Liang Cheng; He Qian; Wei-Rong Yao (Natural Product Research, 2021)

Isolation of two sesquiterpene glycosides from Sapindus mukorossi Gaertn. with cytotoxic properties and analysis of their mechanism based on network pharmacology - Min-ping Wei; Xiao-wen Zhu; Hang Yu; Yun-fei Xie; Ya-hui Guo; Yu-liang Cheng; He Qian; Wei-rong Yao (Natural Product Research, 2021)

Evaluation of long-term performance of plant microbial fuel cells using agricultural plants under the controlled environment - Natagarn Tongphanpharn; Chung-Yu Guan; Wei-Shan Chen; Chao-Chin Chang; Chang-Ping Yu (Clean Technologies and Environmental Policy, 2021)

Cytotoxic triterpenoid glycosides from leaves of Cyclocarya paliurus - Hui-Hui Sun; Wen-Yan Lv; Jie Tan; Yu-Cheng Tang; Hui Zhu; Jian-Bo Qu; Jing Li; Jian-Ping Wu; Xi-Wen Chang; Zhi-Chun Yang; Wen-Xuan Wang; Zu-Hui Chen; et al. (Natural Product Research, 2021)

Optimizing the Design of Blood–Brain Barrier-Penetrating Polymer-Lipid-Hybrid Nanoparticles for Delivering Anticancer Drugs to Glioblastoma - Taksim Ahmed; Fuh-Ching Franky Liu; Chungsheng He; Azhar Z. Abbasi; Ping Cai; Andrew M. Rauth; Jeffery T. Henderson; Xiao Yu Wu (Pharmaceutical Research, 2021)

Developments in Biological Mechanisms and Treatments for Negative Symptoms and Cognitive Dysfunction of Schizophrenia - Qiongqiong Wu; Xiaoyi Wang; Ying Wang; Yu-Jun Long; Jing-Ping Zhao; Ren-Rong Wu (Neuroscience Bulletin, 2021)
The causal mechanisms and treatment for the negative symptoms and cognitive dysfunction in schizophrenia are the main issues attracting the attention of psychiatrists over the last decade. The first part of this review summarizes the pathogenesis of schizophrenia, especially the negative symptoms and cognitive dysfunction from the perspectives of genetics and epigenetics. The second part describes the novel medications and several advanced physical therapies (e.g., transcranial magnetic stimulation and transcranial direct current stimulation) for the negative symptoms and cognitive dysfunction that will optimize the therapeutic strategy for patients with schizophrenia in future.

Analysis of Dangchuan 5# landslide on January 27, 2021, in Yongjing County, Gansu Province, China - Wenbin Chang; Aiguo Xing; Ping Wang; Yu Zhuang; Kaiping Jin; Junyi He; Shaofeng Chai (Landslides, 2021)

Differences in pathogenicity and physiologic races between Pyricularia oryzae isolates from indica and japonica rice varieties - Zhong-na Hao; Zhen Zhang; Hai-ping Qiu; Rong-yao Chai; Shi-zhen Wang; Yan-li Wang; Jiao-yu Wang; Guo-chang Sun (Journal of Plant Pathology, 2021)

Impact of rhizosphere microorganisms on arsenic (As) transformation and accumulation in a traditional Chinese medical plant - Jiao-Jiao Li; Long Yang; Cui-Ping Miao; Ya-Jun Teng; Zi-Hao Fu; Chang-Lei Cheng; Xue-Xiu Chang; Yu Qian; Li-Xing Zhao (Environmental Science and Pollution Research, 2021)

Reduced Serum Zinc Ion Concentration Is Associated with Coronary Heart Disease - Heyu Meng; Yueying Wang; Fengfeng Zhou; Jianjun Ruan; Meiyu Duan; Xue Wang; Qiong Yu; Ping Yang; Weiwei Chen; Fanbo Meng (Biological Trace Element Research, 2021)

Hydrological characteristics and changes in the Nu-Salween River basin revealed with model-based reconstructed data - Fan Yang; Hui Lu; Kun Yang; Guang-wei Huang; Yi-shan Li; Wei Wang; Ping Lu; Fu-qiang Tian; Yu-gang Huang (Journal of Mountain Science, 2021)

Induced production of a new polyketide in Penicillium sp. HS-11 by chemical epigenetic manipulation - You-Min Ying; Ling Li; Hang-Fei Yu; Yi-Lian Xu; Lu Huang; Wei Mao; Cui-Ping Tong; Zhi-Dong Zhang; Zha-Jun Zhan; Yun Zhang (Natural Product Research, 2021)

Updated taxonomy of Chinese Phylloporus (Boletaceae, Boletales): six new taxa and four redescribed species - Lu-Ling Wu; Zhi-Qun Liang; Ming-Sheng Su; Yu-Guang Fan; Ping Zhang; Shuai Jiang; Yan-Liu Chen; Yan-Jia Hao; Nian-Kai Zeng (Mycological Progress, 2021)

Emerging role of air pollution in chronic kidney disease - Yue Chen; Fan Cao; Jian-Ping Xiao; Xin-Yu Fang; Xue-Rong Wang; Li-Hong Ding; De-Guang Wang; Hai-Feng Pan (Environmental Science and Pollution Research, 2021)

Prenatal phthalate exposure reduction through an integrated intervention strategy - Wei Wu; Liu Cao; Ting-Ting Zheng; Shu-Yu Feng; Guan-Wei Ma; Ying-Ying He; Ping Wu (Environmental Science and Pollution Research, 2021)

Aberrant activity within auditory network is associated with psychiatric comorbidities in interictal migraineurs without aura - Heng-Le Wei; Yu-Chen Chen; Yu-Sheng Yu; Xi Guo; Gang-Ping Zhou; Qing-Qing Zhou; Li-Jie Qu; Xindao Yin; Junrong Li; Hong Zhang (Brain Imaging and Behavior, 2021)

Two-pore physiologically based pharmacokinetic model validation using whole-body biodistribution of trastuzumab and different-size fragments in mice - Zhe Li; Yingyi Li; Hsuan Ping Chang; Xiaoying Yu; Dhaval K. Shah (Journal of Pharmacokinetics and Pharmacodynamics, 2021)

Sandaracinobacteroides hominis gen. nov., sp. nov., isolated from human skin - Ping-Hua Qu; Hai-Min Luo; Jun-Hui Feng; Song Li; Cha Chen; Lei Dong; Yu-Zhen Ming; Wen-Jun Li; Ying Lin (Archives of Microbiology, 2021)

Geochemical characteristics of the lower Cambrian Qiongzhusi Formation in Huize area, east Yunnan: implications for paleo-ocean environment and the origin of black rock series - Yong Cheng; Weiqing Liu; Wei Wu; Yu Zhang; Guo Tang; Cong Liu; Qi Nie; Yiming Wen; Ping Lu; Chuanyu Zhang (Arabian Journal of Geosciences, 2021)

Problem-solving deficits in methcathinone use disorder - Hang-Bin Zhang; Di Zhao; Yu-Ping Liu; Li-Xun Wang; Bo Yang; Ti-Fei Yuan (Psychopharmacology, 2021)

A study on groundwater recharge in the Anyanghe River alluvial fan, North China Plain, based on hydrochemistry, stable isotopes and tritium - Xiangui Huang; Jianhua Ping; Wei Leng; Yan Yu; Min Zhang; Yaqiang Zhu (Hydrogeology Journal, 2021)

Protective effect of Bombyx mori gloverin on intestinal epithelial cells exposure to enterotoxigenic E. coli - Qian Lin; Qingqing Fu; Guoqi Su; Daiwen Chen; Bing Yu; Yuheng Luo; Ping Zheng; Xiangbing Mao; Zhiqing Huang; Jie Yu; Junqiu Luo; Hui Yan; et al. (Brazilian Journal of Microbiology, 2021)

Biogas Production and Microbial Communities in the Anaerobic Digestion of Sewage Sludge Under Hydrothermal Pretreatment with Air and a Catalyst - Van Toi Pham; Pei-Hsun Wu; Chung-Yu Guan; Chia-Chi Chang; Bo-Liang Liu; Ching-Yuan Chang; Chang-Ping Yu (BioEnergy Research, 2021)

Puerarin reduces impairment of intestinal and adipose immune responses to influenza virus infection in mice - Mao-Seng Zeng; Wen-Di Yu; Hui-Xian Wang; Pei-Ping Xu; Jin-Yuan Liu (Archives of Virology, 2021)

Spatiotemporal characteristics and trend assessment of Ms ≥ 5.6 earthquakes in the Tianshan area of China based on co-occurrence analysis and commensurability - Jia Wan; Jun-Ping Yan; Zi-Qiang Liu; Xiao-Meng Wang; Yu-Feng Zhang; Cheng-Bo Wang (Applied Geophysics, 2021)

A new p -terphenyl derivative from the fruiting bodies of Sarcodon imbricatus (L.) P. Karst - Feng-Ming Zhang; Yue-Hu Wang; Ping Zhao; Fu-Qiang Yu (Natural Product Research, 2021)

Enhancing the production of γ-aminobutyric acid in Escherichia coli BL21 by engineering the enzymes of the regeneration pathway of the coenzyme factor pyridoxal 5’-phosphate - Ping Yu; Jian Ma; Pengzhi Zhu; Qingwei Chen; Qili Zhang (World Journal of Microbiology and Biotechnology, 2021)

Hyperglycemia-Induced Cardiac Damage Is Alleviated by Heat-Inactivated Lactobacillus reuteri GMNL-263 via Activation of the IGF1R Survival Pathway - Ker-Ping Koay; Bruce Chi-Kang Tsai; Chia-Hua Kuo; Wei-Wen Kuo; Hsiang-Ning Luk; Cecilia Hsuan Day; Ray-Jade Chen; Michael Yu-Chih Chen; V. Vijaya Padma; Chih-Yang Huang (Probiotics and Antimicrobial Proteins, 2021)

Overexpression of MdPHR1 Enhanced Tolerance to Phosphorus Deficiency by Increasing MdPAP10 Transcription in Apple (Malus × Domestica) - Rui Li; Jian-Ping An; Chun-Xiang You; Xiao-Fei Wang; Yu-Jin Hao (Journal of Plant Growth Regulation, 2021)

Genetic diversity of potato virus Y potato isolates from Shandong province, China - Meng-Ao Jia; Lu Wang; Ji-Wu Zhang; Yu-Shuang Guo; Xiang-Dong Li; Yan-Ping Tian (Journal of Plant Pathology, 2021)

Performance Comparison of the Deep Learning and the Human Endoscopist for Bleeding Peptic Ulcer Disease - Hsu-Heng Yen; Ping-Yu Wu; Pei-Yuan Su; Chia-Wei Yang; Yang-Yuan Chen; Mei-Fen Chen; Wen-Chen Lin; Cheng-Lun Tsai; Kang-Ping Lin (Journal of Medical and Biological Engineering, 2021)
Purpose Management of peptic ulcer bleeding is clinically challenging. Accurate characterization of the bleeding during endoscopy is key for endoscopic therapy. This study aimed to assess whether a deep learning model can aid in the classification of bleeding peptic ulcer disease. Methods Endoscopic still images of patients ( n = 1694) with peptic ulcer bleeding for the last 5 years were retrieved and reviewed. Overall, 2289 images were collected for deep learning model training, and 449 images were validated for the performance test. Two expert endoscopists classified the images into different classes based on their appearance. Four deep learning models, including Mobile Net V2, VGG16, Inception V4, and ResNet50, were proposed and pre-trained by ImageNet with the established convolutional neural network algorithm. A comparison of the endoscopists and trained deep learning model was performed to evaluate the model’s performance on a dataset of 449 testing images. Results The results first presented the performance comparisons of four deep learning models. The Mobile Net V2 presented the optimal performance of the proposal models. The Mobile Net V2 was chosen for further comparing the performance with the diagnostic results obtained by one senior and one novice endoscopists. The sensitivity and specificity were acceptable for the prediction of “normal” lesions in both 3-class and 4-class classifications. For the 3-class category, the sensitivity and specificity were 94.83% and 92.36%, respectively. For the 4-class category, the sensitivity and specificity were 95.40% and 92.70%, respectively. The interobserver agreement of the testing dataset of the model was moderate to substantial with the senior endoscopist. The accuracy of the determination of endoscopic therapy required and high-risk endoscopic therapy of the deep learning model was higher than that of the novice endoscopist. Conclusions In this study, the deep learning model performed better than inexperienced endoscopists. Further improvement of the model may aid in clinical decision-making during clinical practice, especially for trainee endoscopist.

Gas-phase isopropanol degradation by nonthermal plasma combined with Mn-Cu/-Al2O3 - Ken-Lin Chang; Yu-Chieh Lin; Ming-Ze Qiu; Chun-Wei Tu; Chih-Ping Chang; Jhong-Lin Wu; Yung-Chang Lin; Chien-Kuei Chang (Environmental Science and Pollution Research, 2021)

Enrichment of marine productivity utilizing steelmaking slag: managing conflicting stakeholders’ interests in Taiwan - Yung-Sheng Chen; Ming-Sheng Ko; Yu-Cheng Wang; Ping Chen; Ta-Kang Liu (Aquaculture International, 2021)

Genetic mapping of highly versatile and solvent‐tolerant Pseudomonas putida B6 ‐2 ( ATCC BAA ‐2545) as a ‘superstar’ for mineralization of PAHs and dioxin‐like compounds - Weiwei Wang; Qinggang Li; Lige Zhang; Jie Cui; Hao Yu; Xiaoyu Wang; Xingyu Ouyang; Fei Tao; Ping Xu; Hongzhi Tang (Environmental Microbiology, 2021)
Summary Polycyclic aromatic hydrocarbons (PAHs) and dioxin‐like compounds, including sulfur, nitrogen and oxygen heterocycles, are widespread and toxic environmental pollutants. A wide variety of microorganisms capable of growing with aromatic polycyclic compounds are essential for bioremediation of the contaminated sites and the Earth's carbon cycle. Here, cells of Pseudomonas putida B6‐2 (ATCC BAA‐2545) grown in the presence of biphenyl (BP) are able to simultaneously degrade PAHs and their derivatives, even when they are present as mixtures, and tolerate high concentrations of extremely toxic solvents. Genetic analysis of the 6.37 Mb genome of strain B6‐2 reveals coexistence of gene clusters responsible for central catabolic systems of aromatic compounds and for solvent tolerance. We used functional transcriptomics and proteomics to identify the candidate genes associated with catabolism of BP and a mixture of BP, dibenzofuran, dibenzothiophene and carbazole. Moreover, we observed dynamic changes in transcriptional levels with BP, including in metabolic pathways of aromatic compounds, chemotaxis, efflux pumps and transporters potentially involved in adaptation to PAHs. This study on the highly versatile activities of strain B6‐2 suggests it to be a potentially useful model for bioremediation of polluted sites and for investigation of biochemical, genetic and evolutionary aspects of Pseudomonas .

MdBZR1 regulates ABA response by modulating the expression of MdABI5 in apple - Ya-Jing Liu; Jian-Ping An; Xiao-Fei Wang; Ning Gao; Xun Wang; Shuai Zhang; Wen-Sheng Gao; Yu-Jin Hao; Chun-Xiang You (Plant Cell Reports, 2021)

Genetic Analysis of ZNF Protein Family Members for Early-Onset Parkinson’s Disease in Chinese Population - Chun Yu Li; Ru Wei Ou; Yong Ping Chen; Xiao Jing Gu; Qian Qian Wei; Bei Cao; Ling Yu Zhang; Yan Bing Hou; Kun Cheng Liu; Xue Ping Chen; Wei Song; Bi Zhao; et al. (Molecular Neurobiology, 2021)

Integrative analysis of miRNAs and mRNAs revealed regulation of lipid metabolism in dairy cattle - Lixin Xia; Zhihui Zhao; Xianzhong Yu; Chunyan Lu; Ping Jiang; Haibin Yu; Xiaohui Li; Xiang Yu; Juan Liu; Xibi Fang; Runjun Yang (Functional & Integrative Genomics, 2021)

Investigation of the cumulative influence of infiltration on the slope stability with a thick unsaturated zone - Xiaokun Hou; Tonglu Li; Shengwen Qi; Songfeng Guo; Ping Li; Yu Xi; Xianli Xing (Bulletin of Engineering Geology and the Environment, 2021)

Neuroprotective carbazole alkaloids from the stems and leaves of Clausena lenis - Gui Yan; Yu-Jie Li; Ying-Ying Zhao; Jia-Ming Guo; Wen-Hao Zhang; Ming-Ming Zhang; Yan-Hui Fu; Yan-Ping Liu (Natural Product Research, 2021)

Phenylpropanoids and lignoids from the whole plant of Vaccinium emarginatum and their cytotoxicity against prostate cancer cells - Ping-Chen Tu; Yu-Chia Liang; Ming-Ching Kao; Louis Kuoping Chao; Mei-Hwei Tseng; Te-Ling Lu; Ping-Jyun Sung; Yueh-Hsiung Kuo (Natural Product Research, 2021)

Steroidal glycosides from the underground parts of Hosta ventricosa and their anti-inflammatory activities in mice - Hong-Biao Chu; Nan-Nan Li; Zong-Ping Zhang; Xiao-Yue Hu; Cai-Yun Yu; Lei Hua (Natural Product Research, 2021)

Ziziphus jujuba Mill., a plant used as medicinal food: a review of its phytochemistry, pharmacology, quality control and future research - Shi-Jun Liu; Yan-Ping Lv; Zhi-Shu Tang; Yu Zhang; Hong-Bo Xu; Dong-Bo Zhang; Chun-Li Cui; Hong-Bo Liu; Huan-Huan Sun; Zhong-Xing Song; Si-Min Wei (Phytochemistry Reviews, 2021)

Correction to: Genomic Action of Sigma-1 Receptor Chaperone Relates to Neuropathic Pain - Shao-Ming Wang; Nino Goguadze; Yuriko Kimura; Yuko Yasui; Bin Pan; Tzu-Yun Wang; Yoki Nakamura; Yu-Ting Lin; Quinn H. Hogan; Katherine L. Wilson; Tsung-Ping Su; Hsiang-en Wu (Molecular Neurobiology, 2021)
A correction to this paper has been published: 10.1007/s12035-021-02310-3

Genomic Action of Sigma-1 Receptor Chaperone Relates to Neuropathic Pain - Shao-Ming Wang; Nino Goguadze; Yuriko Kimura; Yuko Yasui; Bin Pan; Tzu-Yun Wang; Yoki Nakamura; Yu-Ting Lin; Quinn H. Hogan; Katherine L. Wilson; Tsung-Ping Su; Hsiang-en Wu (Molecular Neurobiology, 2021)
Sigma-1 receptors (Sig-1Rs) are endoplasmic reticulum (ER) chaperones implicated in neuropathic pain. Here we examine if the Sig-1R may relate to neuropathic pain at the level of dorsal root ganglia (DRG). We focus on the neuronal excitability of DRG in a “spare nerve injury” (SNI) model of neuropathic pain in rats and find that Sig-1Rs likely contribute to the genesis of DRG neuronal excitability by decreasing the protein level of voltage-gated Cav2.2 as a translational inhibitor of mRNA. Specifically, during SNI, Sig-1Rs translocate from ER to the nuclear envelope via a trafficking protein Sec61β. At the nucleus, the Sig-1R interacts with cFos and binds to the promoter of 4E-BP1, leading to an upregulation of 4E-BP1 that binds and prevents eIF4E from initiating the mRNA translation for Cav2.2. Interestingly, in Sig-1R knockout HEK cells, Cav2.2 is upregulated. In accordance with those findings, we find that intra-DRG injection of Sig-1R agonist (+)pentazocine increases frequency of action potentials via regulation of voltage-gated Ca2+ channels. Conversely, intra-DRG injection of Sig-1R antagonist BD1047 attenuates neuropathic pain. Hence, we discover that the Sig-1R chaperone causes neuropathic pain indirectly as a translational inhibitor.

Schizocorticium gen. nov. (Hymenochaetales, Basidiomycota) with three new species - Sheng-Hua Wu; Chia-Ling Wei; Yu-Ping Chen; Che-Chih Chen; Siou-Zhen Chen (Mycological Progress, 2021)

Generation and identification of endothelial-specific Hrh2 knockout mice - Rui Meng; Wen-Ke Cai; Wen-Mang Xu; Qiang Feng; Ping Wang; Yan-hua Huang; Yu-Xin Fan; Tao Zhou; Qin Yang; Zhi-Ran Li; Gong-Hao He (Transgenic Research, 2021)

A dye combination for the staining of pollen coat and pollen wall - Xin-Lei Jia; Jing-Shi Xue; Fang Zhang; Chi Yao; Shi-Yi Shen; Chang-Xu Sui; Yu-Jia Peng; Qin-Lin Xu; Yi-Feng Feng; Wen-Jing Hu; Ping Xu; Zhong-Nan Yang (Plant Reproduction, 2021)

LAI scale effect research based on compact airborne spectrographic imager data in the Heihe Oasis - Xiao-ai Dai; Chao Liu; Nai-wen Li; Mei-lian Wang; Yu-wei Yang; Xing-ping Yang; Shi-qi Zhang; Xu-wei He; Zheng-li Yang; Heng Lu; Jing-zhong Li; Ze-kun Wang (Journal of Mountain Science, 2021)

Spatial distribution pattern in mammal and bird richness and their relationship with ecosystem services in Sanjiangyuan National Park, China - Hua-wei Wan; Hao-xin Li; Jin-hui Wu; Yu-ping Liu (Journal of Mountain Science, 2021)

Cytotoxic p -terphenyls from the deep-sea-derived Aspergillus candidus - Yu-Kun Lin; Chun-Lan Xie; Cui-Ping Xing; Bao-Qu Wang; Xiao-Xue Tian; Jin-Mei Xia; Ling-Yun Jia; Ying-Ni Pan; Xian-Wen Yang (Natural Product Research, 2021)

Cytotoxic meroterpenoids from the marine sponge Dactylospongia elegans - Hao-Bing Yu; Zi-Fei Yin; Bin-Bin Gu; Jian-Peng Zhang; Shu-Ping Wang; Fan Yang; Hou-Wen Lin (Natural Product Research, 2021)

Vitexnegheteroin M, a new phenolic glycoside from Vitex negundo var. heterophylla - Ye Huang; Guo-Yu Ding; Ping Hu (Natural Product Research, 2021)

A Two-Pore Physiologically Based Pharmacokinetic Model to Predict Subcutaneously Administered Different-Size Antibody/Antibody Fragments - Zhe Li; Xiaoying Yu; Yingyi Li; Ashwni Verma; Hsuan Ping Chang; Dhaval K. Shah (The AAPS Journal, 2021)

Study on Microwave Heating Order and Electromagnetic Characteristics of Copper and Gold Ores - Feng Lin; Xia-Ting Feng; Gao-Ming Lu; Xiang-Xin Su; Shi-Ping Li; Jiu-yu Zhang (Rock Mechanics and Rock Engineering, 2021)

Reduction of OsMPK6 activity by a R89K mutation induces cell death and bacterial blight resistance in rice - Dongfei Wang; Hong Wang; Qunen Liu; Ranran Tu; Xingpeng Zhou; Yingxin Zhang; Weixun Wu; Ping Yu; Daibo Chen; Xiaodeng Zhan; Liyong Cao; Shihua Cheng; et al. (Plant Cell Reports, 2021)

Antifungal Effect of Long Noncoding RNA 9708-1 in the Vulvovaginal Candidiasis Murine Model - Ying Wu; Lisha Jiang; Lingling Zhang; Xia Liu; Lina Yan; Ting Luan; Can Rui; Zhiyuan Mao; Chong Fan; Yu Liu; Ping Li; Xin Zeng (Mycopathologia, 2021)
Vulvovaginal candidiasis (VVC) caused by Candida spp. affects 70–75% of women at least once during their lives. We aim to elucidate the potential mechanism of VVC and investigate the therapeutic effects of long noncoding RNA 9708-1. Female BALB/c mice were randomized to four treatment groups, including the blank control group, VVC control group, vehicle control group and lncRNA 9708-1-overexpressed group. Mice were euthanized on Day 4, Day 7 and Day 14 after treatment. Colony-forming unit (CFU) was measured, and the inflammation was detected by hematoxylin and eosin (H&E). Gene and protein expression levels of lncRNA 9708-1 and FAK were determined by real-time PCR, Western blot and immunohistochemistry. The overexpression of lncRNA 9708-1 significantly decreased the fungal load from Day 4 to 7. H&E staining indicated that the impaired histological profiles were improved in lncRNA 9708-1-overexpressed group. LncRNA 9708-1 led to a significant increase in FAK level of vagina tissue which is expressed mainly in epithelial basal layer. This study suggests that lncRNA 9708-1 played a protective role on murine experimental VVC by upregulating the expression levels of FAK.

Inhibition of ASIC-Mediated Currents by Activation of Somatostatin 2 Receptors in Rat Dorsal Root Ganglion Neurons - Ting-Ting Liu; Shuang Wei; Ying Jin; Chun-Yu Qiu; Wang-Ping Hu (Molecular Neurobiology, 2021)

Synthesis and antitumor evaluation of (aryl)methyl-amine derivatives of dehydroabietic acid-based B ring-fused-thiazole as potential PI3K/AKT/mTOR signaling pathway inhibitors - Nai-Yuan Chen; Yu-Lan Xie; Guo-Dong Lu; Fang Ye; Xin-Yu Li; Yu-Wen Huang; Ming-Li Huang; Tie-Yu Chen; Cui-Ping Li (Molecular Diversity, 2021)

Fast and slow responses of the Subantarctic Mode Water in the South Indian Ocean to global warming in CMIP5 extended RCP4.5 simulations - Xingyue Xia; Lixiao Xu; Shang-Ping Xie; Yu Hong; Yan Du (Climate Dynamics, 2021)

Exposed to Mercury-Induced Oxidative Stress, Changes of Intestinal Microflora, and Association between them in Mice - Yulan Zhao; Changming Zhou; Xiaoquan Guo; Guoliang Hu; Guyue Li; Yu Zhuang; Huabin Cao; Lin Li; Chonghong Xing; Caiying Zhang; Fan Yang; Ping Liu (Biological Trace Element Research, 2021)

Emergent chikungunya fever and vertical transmission in Yunnan Province, China, 2019 - XiaoXiong Yin; Ting-Song Hu; HaiLin Zhang; YongHua Liu; ZhiJian Zhou; LeBin Liu; Ping Li; YiYin Wang; ZhaoLan Yang; Jing Yu; SiYu Chen; Fu-Qiang Zhang (Archives of Virology, 2021)

Genome sequencing and functional annotation of Bacillus sp. strain BS-Z15 isolated from cotton rhizosphere soil having antagonistic activity against Verticillium dahliae - Zhong-Yi Chen; Xieerwanimu Abuduaini; Nuramina Mamat; Qi-Lin Yang; Meng-Jun Wu; Xin-Rui Lin; Ru Wang; Rong-Rong Lin; Wei-Jun Zeng; Huan-Chen Ning; He-Ping Zhao; Jin-Yu Li; et al. (Archives of Microbiology, 2021)

Genome analysis of Salmonella phage vB_SalM_8-19 (genus Rosemountvirus) - Cong Cong; Wei Bing Dong; Cui Hui Jing; Yuan Yu Yu; Xu Yong Ping; Wang Li Li; Li Shu Ying; Li Ji Bin; Xu Mu; Li Xiao Yu (Archives of Microbiology, 2021)

GAS5 regulates viability and apoptosis in TGF-β1-stimulated bronchial epithelial cells by regulating miR-217/HDAC4 axis - Sihui Zhao; Yunfang Ning; Na Qin; Nan Ping; Yong Yu; Guoyan Yin (Genes & Genomics, 2021)

Effects of Spray Parameters on the Effective Spray Width of Single-Rotor Drone in Sugarcane Plant Protection - Ping Zhang; Wei Zhang; Hai-Tian Sun; Feng-Guang He; Hai-Ba Fu; Li-Qiang Qi; Li-Juan Yu; Li-Yu Jin; Bo Zhang; Jian-Sheng Liu (Sugar Tech, 2021)

Human β-Defensin 118 Attenuates Escherichia coli K88–Induced Inflammation and Intestinal Injury in Mice - Qian Lin; Qingqing Fu; Xiang Li; Yuheng Luo; Junqiu Luo; Daiwen Chen; Xiangbing Mao; Bing Yu; Ping Zheng; Zhiqing Huang; Jie Yu; Hui Yan; et al. (Probiotics and Antimicrobial Proteins, 2021)

miR-20a Promotes the Axon Regeneration of DRG Neurons by Targeting Nr4a3 - Lili Zhao; Leilei Gong; Ping Li; Jing Qin; Lingchi Xu; Qiyao Wei; Huimin Xie; Susu Mao; Bin Yu; Xiaosong Gu; Songlin Zhou (Neuroscience Bulletin, 2021)

Pramipexole attenuates 6-OHDA-induced Parkinson’s disease by mediating the Nurr1/NF-κB pathway - Hua Gao; Dan Wang; Yu-Ling Wang; Jie-Ping Mao; Sen Jiang; Xin-Ling Yang (Molecular Biology Reports, 2021)

Genetic Analysis of Prosaposin, the Lysosomal Storage Disorder Gene in Parkinson’s Disease - Yong-Ping Chen; Xiao-Jing Gu; Ru-Wei Ou; Ling-Yu Zhang; Yan-Bing Hou; Kun-Cheng Liu; Bei Cao; Qian-Qian Wei; Wei Song; Bi Zhao; Ying Wu; Jing-Qiu Cheng; et al. (Molecular Neurobiology, 2021)

Simulation of the Q2 loess slope with seepage fissure failure and seismic response via discrete element method - Wenbin Chang; Ping Wang; Huijuan Wang; Shaofeng Chai; Yifan Yu; Shiyang Xu (Bulletin of Engineering Geology and the Environment, 2021)

Carbon monoxide-triggered health effects: the important role of the inflammasome and its possible crosstalk with autophagy and exosomes - Rong-Jane Chen; Yu-Hsuan Lee; Tzu-Hao Chen; Yu-Ying Chen; Ya-Ling Yeh; Ching-Ping Chang; Chien-Cheng Huang; How-Ran Guo; Ying-Jan Wang (Archives of Toxicology, 2021)

The effects of land use changes on climate warming by source-sink theory - Shuang-shuang Hou; Li-fei Yu; Wei Yan; Shu-hong Gu; Xiao-ping Gu (Arabian Journal of Geosciences, 2021)

Thermaurantiacus tibetensis gen. nov., sp. nov., a novel moderately thermophilic bacterium isolated from hot spring microbial mat in Tibet - Yu-Zhen Ming; Lan Liu; Ai-Ping Lv; Wen-Dong Xian; Ze-Tao Liu; Meng-Meng Li; Jian-Yu Jiao; Bao-Zhu Fang; Wen-Jun Li (Antonie van Leeuwenhoek, 2021)

Evaluation of climate model simulations in representing the precipitation non‐stationarity by considering observational uncertainties - Yongjing Wan; Jie Chen; Ping Xie; Chong‐Yu Xu; Daiyuan Li (International Journal of Climatology, 2021)
The reliability of climate model simulations in representing the precipitation changes is one of the preconditions for climate‐change impact studies. However, the observational uncertainties hinder the robust evaluation of these climate model simulations. The goal of the present study is to evaluate the capacities of climate model simulations in representing the precipitation non‐stationarity in consideration of observational uncertainties. The mean of multiple observations from five observational precipitation datasets is used as a reference to quantify the uncertainty of observed precipitation and to evaluate the performance of climate model simulations. The non‐stationarity of precipitation was represented using the mean and variance of annual total precipitation and annual maximum daily precipitation for the 1982–2015 period. The results show that the spatial distributions of annual and extreme precipitation are similar for various observational datasets, while there has less agreement in the variance changes of extreme precipitation. Climate models are capable of representing the spatial distributions of the annual and extreme precipitation amounts at the global scales. In terms of the non‐stationarity, climate model simulations are capable of capturing the large‐scale spatial pattern of the trend in mean for annual precipitation. On the contrary, the simulations are less reliable in reproducing the change of extreme precipitation, as well as the trend of variance for annual precipitation. Overall, climate models are more reliable in simulating the mean of precipitation than the variance, and they are more reliable in simulating annual precipitation than extreme. Besides, the uncertainties of precipitation for both observations and simulations are much larger in monsoon regions than in other regions. This study suggests that considering observational uncertainties is necessary when using observational datasets as the reference to project future climate change and assess the impact of climate change on environments.

Chlamydia trachomatis induces autophagy by p62 in HeLa cell - Fuyan Wang; Hongbo Zhang; Xiaofang Lu; Quan Zhu; Tingting Shi; Rong Lu; Ping Yu; Lei Zhang; Yong Wang (World Journal of Microbiology and Biotechnology, 2021)

Re-use of wasted sludge to treat industrial pollutants - Ru Wang; Li-ping Yu; Bibi Saima Zeb; Lin-jie Yuan; Meng-yu Liu; Lin-jiang Yuan (Water, Air, & Soil Pollution, 2021)

Biopharmaceutics Applications of Physiologically Based Pharmacokinetic Absorption Modeling and Simulation in Regulatory Submissions to the U.S. Food and Drug Administration for New Drugs - Fang Wu; Heta Shah; Min Li; Peng Duan; Ping Zhao; Sandra Suarez; Kimberly Raines; Yang Zhao; Meng Wang; Ho-pi Lin; John Duan; Lawrence Yu; et al. (The AAPS Journal, 2021)

An Insight into the Excavation-Induced Stress Paths on Mechanical Response of Weak Interlayer Zone in Underground Cavern Under High Geostress - Shu-Qian Duan; Quan Jiang; Guo-Feng Liu; Jie-Cheng Xiong; Po Gao; Ding-Ping Xu; Ming-Yu Li (Rock Mechanics and Rock Engineering, 2021)

Quantitative proteomic analysis of pear (Pyrus pyrifolia cv. “Hosui”) flesh provides novel insights about development and quality characteristics of fruit - Hu Ping Zhang; Ying Su; Qing Yu; Gai Hua Qin (Planta, 2021)

Decreased grain size1, a C3HC4-type RING protein, influences grain size in rice (Oryza sativa L.) - Xingjie Zhu; Shengzhong Zhang; Yaping Chen; Changlin Mou; Yunshuai Huang; Xi Liu; Jingli Ji; Jiangfeng Yu; Qixian Hao; Chunyan Yang; Mengying Cai; Thanhliem Nguyen; et al. (Plant Molecular Biology, 2021)

Neonatal Sevoflurane Exposure Impairs Learning and Memory by the Hypermethylation of Hippocampal Synaptic Genes - Xin-Yu Fan; Guang Shi; Ping Zhao (Molecular Neurobiology, 2021)