Damage detection of bridges subjected to moving load based on domain-adversarial neural network considering measurement and model error - Zhi-Dong Li; Wen-Yu He; Wei-Xin Ren; Yi-Lin Li; Yi-Fan Li; Hua-Cai Cheng (Engineering Structures, 2023)

Combining HUMSC secretome and a conductive hydrogel enhances angiogenesis and electrical transmission at myocardial infarct sites to support cardiac repair - Shu-yi He; Lin-yu Long; Zhi-cun Wang; Wen-qi Liu; Wen Zhang; Cheng Hu; Xiao-feng Wu; Ruiqi Dong; Hong-song Fan; Qing-Jiang; Ying-ying Tong; Guang-hua Yang; et al. (Chemical Engineering Journal, 2023)

Heart valve-inspired self-lubricating anticoagulant surfaces - Yang Cheng; Zhiwei Yang; Xiaodan Gou; Qing Yang; Zichen Zhang; Shiyu Cui; Yuhua Ren; Lihong Fan; Haifeng Zhang; Zheng Fang; Yu Lu; Lin Kai; et al. (Chemical Engineering Journal, 2023)

A multilayer perceptron-based fast sunlight assessment for the conceptual design of residential neighborhoods under Chinese policy - Can Jiang; Xiong Liang; Yu-cheng Zhou; Yong Tian; Shengli Xu; Jia-Rui Lin; Zhiliang Ma; Shiji Yang; Hao Zhou (Building and Environment, 2023)

Long-term field calibration of low-cost metal oxide VOC sensor: Meteorological and interference gas effects - Gung-Hwa Hong; Thi-Cuc Le; Guan-Yu Lin; Hung-Wen Cheng; Jhih-Yuan Yu; Racha Dejchanchaiwong; Perapong Tekasakul; Chuen-Jinn Tsai (Atmospheric Environment, 2023)

A pan-coronavirus peptide inhibitor prevents SARS-CoV-2 infection in mice by intranasal delivery - Lili Wu; Anqi Zheng; Yangming Tang; Yan Chai; Jiantao Chen; Lin Cheng; Yu Hu; Jing Qu; Wenwen Lei; William Jun Liu; Guizhen Wu; Shaogui Zeng; et al. (Science China Life Sciences, 2023)

Targeting mitochondrial dynamics by AZD5363 in triple-negative breast cancer MDA-MB-231 cell–derived spheres - Yingqiang Fu; Wei Dong; Yuting Xu; Lin Li; Xin Yu; Yuheng Pang; Liujia Chan; Yuhan Deng; Cheng Qian (Naunyn-Schmiedeberg's Archives of Pharmacology, 2023)
Breast cancer stem cells (BCSCs) have been suggested to contribute to chemotherapeutic resistance and disease relapse in breast cancer. Thus, BCSCs represent a promising target in developing novel breast cancer treatment strategies. Mitochondrial dynamics in BCSCs were recently highlighted as an available approach for targeting BCSCs. In this study, a three-dimensional (3D) cultured breast cancer stem cell spheres model was constructed. Mitochondrial dynamics and functions were analyzed by flow cytometry and confocal microscopy. We have demonstrated that the protein levels of FIS 1 and Mitofusin 1 were significantly increased in BCSCs. Moreover, Capivasertib (AZD5363) administration could suppress Mitofusin1 expression in BCSCs. Our use of MitoTracker Orange and annexin V double-staining assay suggested that AZD5363 could induce apoptosis in BCSCs. The sensitivity of stem cell spheres to doxorubicin was investigated by CCK8 assay, and our results indicated that AZD5363 could re-sensitize BCSCs to Doxo. Flow cytometry analysis identified doxo-induced CD44 and CD133 expression in BCSCs could be suppressed by AZD5363. In combination with AZD536, doxo-induced apoptosis in the BCSCs was significantly increased. In conclusion, our study explored, for the first time, that AZD5363 could target mitochondrial dynamics in 3D cultured stem cell spheres (BCSCs) by regulating Mitofusin.

Severity of Liver Cirrhosis Evaluated by Digital Subtraction Angiography Using Quantitative Color-Coding Analysis Before Transarterial Embolization - Lung-Hui Giiang; Chang-Hsien Liu; Chih-Yung Yu; Te-Pao Lin; Hsiang-Cheng Chen; Chun-Jung Juan; Yu-Ching Chou (Journal of Medical and Biological Engineering, 2023)

A concise chemoenzymatic total synthesis of neutral Globo-series glycosphingolipids Globo A and Globo B, and Forssman and para-Forssman antigens - Yu-Ching Chiang; Chun-Yen Wu; Pei-Yun Chiang; Avijit K. Adak; Chun-Cheng Lin (Glycoconjugate Journal, 2023)

Effects of Fermented Cottonseed Meal Substitution for Fish Meal on Intestinal Enzymatic Activity, Inflammatory and Physical-Barrier-Related Gene Expression, and Intestinal Microflora of Juvenile Golden Pompano (Trachinotus ovatus) - Zhanzhan Wang; Shuling Liao; Jun Wang; Yun Wang; Zhong Huang; Wei Yu; Xiaolin Huang; Heizhao Lin; Maoyan Luo; Zhenyan Cheng; Chuanpeng Zhou (Fishes, 2023)
The present study was conducted to investigate the effects of dietary fermented cottonseed meal (FCSM) substitution for fish meal on intestinal enzymatic activity, inflammatory and physical-barrier-related gene expression, and intestinal microflora of juvenile golden pompano. The 375 golden pompanos were divided into 15 groups of 25 fish each, with three replicates for each experimental group. The fish were fed five experimental diets (0 (FM), 12.5% (CSM12.5), 25% (CSM25), 50% (CSM50), and 100% (CSM100) substitution levels) for 8 weeks. The fish were reared and fed the experimental diets under a natural-day light cycle. Compared with the control group, the activities of AMY (amylase) enzymes in the CSM12.5 group and all other groups were elevated (p

Associations of metal mixtures with thyroid function and potential interactions with iodine status: results from a cross-sectional study in MEWHC - Xiaoting Ge; Junxiu He; Sencai Lin; Yu Bao; Yuan Zheng; Hong Cheng; Haiqing Cai; Xiuming Feng; Wenjun Yang; Sihan Hu; Lin Wang; Qijing Liao; et al. (Environmental Science and Pollution Research, 2023)

Enhanced biomethane production with a low carbon footprint via anaerobic co-digestion of swine wastewater with rice husk - Hung-Cheng Lin; Shu-Yuan Pan; Yu-I Lin; Dan-Thanh Ngoc Cao (Science of The Total Environment, 2023)

A life-threatening bleeding prediction model for immune thrombocytopenia based on personalized machine learning: a nationwide prospective cohort study - Zhuo-Yu An; Ye-Jun Wu; Yu Hou; Heng Mei; Wei-Xia Nong; Wen-Qian Li; Hu Zhou; Ru Feng; Jian-Ping Shen; Jun Peng; Hai Zhou; Yi Liu; et al. (Science Bulletin, 2023)

Application of water-saving irrigation and biostimulants on the agronomic performance of maize (Zea mays) - Cheng-Hsuan Chen; Kuan-Hung Lin; Yu-Sen Chang; Yu-Jie Chang (Process Safety and Environmental Protection, 2023)

Loss of OsARF18 function confers glufosinate resistance in rice - Jin-Qiu Xia; Da-Yu He; Qin-Yu Liang; Zheng-Yi Zhang; Jie Wu; Zi-Sheng Zhang; Jing Zhang; Lin Wang; Cong-He Zhang; Ping-Xia Zhao; Cheng-Bin Xiang (Molecular Plant, 2023)

Open-framework hybrid zinc/tin selenide as an ultrafast adsorbent for Cs+, Ba2+, Co2+, and Ni2+ - Yang Liu; Feng-Qi Shi; Xin Hao; Meng-Yu Li; Lin Cheng; Cheng Wang; Kai-Yao Wang (Journal of Hazardous Materials, 2023)

Spatio-temporal distribution of organochlorine pesticides in agricultural soils of southeast China during 2014-2019 - Wei Zuo; Qin Lin; Xinju Liu; Lu Lv; Chunrong Zhang; Shenggan Wu; Xi Cheng; Yijun Yu; Tao Tang (Environmental Research, 2023)

Honey bee foraging ability suppressed by imidacloprid can be ameliorated by adding adenosine - Yu-Chun Lin; Yun-Heng Lu; Cheng-Kang Tang; En-Cheng Yang; Yueh-Lung Wu (Environmental Pollution, 2023)

β-Cyclodextrin network crosslinked by novel phosphonium-based tetrakiscarboxylic acid derived from PH3 tail gas: Synthesis and application for rapid removal of organic dyes from wastewater - Yu-Lin Hong; Jian Sun; Xiu-Qin Fang; Qing-Wen Liu; Chang Wang; Cheng-Mei Liu (Carbohydrate Polymers, 2023)

Dynamic total factors’ environmental efficiency in European union countries - Ching-Cheng Lu; Yung-ho Chiu; I-Fang Lin; Tai-Yu Lin (Environment, Development and Sustainability, 2023)

A novel diagnostic signature of circulating tsRNAs and miRNAs in esophageal squamous cell carcinoma detected with a microfluidic platform - Di Huang; Yujin Chu; Jiaoyan Qiu; Xiaoshuang Chen; Junhua Zhao; Yu Zhang; Shunjia Li; Yufeng Cheng; Han Shi; Lin Han; Jianbo Wang (Analytica Chimica Acta, 2023)

Quantifying effect of maize tassels on LAI estimation based on multispectral imagery and machine learning methods - Mingchao Shao; Chenwei Nie; Aijun Zhang; Liangsheng Shi; Yuanyuan Zha; Honggen Xu; Hongye Yang; Xun Yu; Yi Bai; Shuaibing Liu; Minghan Cheng; Tao Lin; et al. (Computers and Electronics in Agriculture, 2023)

Daphnane-type diterpenoids from Stellera chamaejasme L. and their inhibitory activity against hepatocellular carcinoma cells - Zhuo-Yang Cheng; Jing-Xian Ren; Xiao-Bian Xue; Man Wang; Xiao-Qi Yu; Bin Lin; Guo-Dong Yao; Shao-Jiang Song; Xiao-Xiao Huang (Phytochemistry, 2023)

A novel framework for spatiotemporal groundwater pumping process estimation based on data-driven approaches - Hwa-Lung Yu; Hua-Ting Tseng; Ying-Fan Lin; Chun-Hung Chen; Ying-Chang Kuo; Yun-Ta Cheng (Journal of Hydrology, 2023)

Maternal exposure to organophosphate flame retardants and neonatal anthropometric measures - Qi Lu; Nan Lin; Xiaomeng Cheng; Xiaoning Lei; Yan Zhang; Yu Gao; Ying Tian (International Journal of Hygiene and Environmental Health, 2023)

Air quality health index (AQHI) based on multiple air pollutants and mortality risks in Taiwan: Construction and validation - Mu-Jean Chen; Yue Leon Guo; Pinpin Lin; Hung-Che Chiang; Pau-Chung Chen; Yu-Cheng Chen (Environmental Research, 2023)

A novel flower-like nickel-metal-organic framework (Ni-MOF) membrane for efficient multi-component pollutants removal by gravity - Lei Han; Jing Ma; Hongjun Lin; Cheng Chen; Jiaheng Teng; Bisheng Li; Dieling Zhao; Yanchao Xu; Wei Yu; Liguo Shen (Chemical Engineering Journal, 2023)

Rational design of surface reconstruction with pinning effect to relieving bulk fatigue for high energy single-crystal Ni-rich cathodes - Ying-de Huang; Han-Xin Wei; Pei-Yao Li; Lin-Bo Tang; Yu-Hong Luo; Xin-Ming Fan; Cheng Yan; Jing Mao; Ke-Hua Dai; He-Zhang Chen; Xia-hui Zhang; Jun-chao Zheng (Chemical Engineering Journal, 2023)

Protonated chitosan nanostructures for enhancing ionic conductivity of solid-state electrolytes - Yinfeng Huang; Yu Cheng; Hong Zhang; Liqiang Mai; Lin Xu (Chemical Engineering Journal, 2023)

Assessing Carbon Abatement Costs Considering Forest Carbon Sequestration and Carbon Offset Mechanism: Evidence from Taiwan - Wan-Yu Liu; Yi-Hsin Lu; Chun-Cheng Lin (Forest Science, 2023)
Based on the Greenhouse Gas Reduction and Management Act passed in 2015 and the carbon neutral target in 2050, Taiwan will most likely follow international trends by imposing carbon taxes and establishing carbon offset markets. The positive and negative effects of carbon taxes and carbon offset markets on the economy and the environment merit further investigation. Accordingly, this study adopted a carbon emission reduction (CER) cost prediction model to assess the carbon abatement costs under three scenarios: (1) a carbon offset market exists, and forest carbon sequestration can be used as carbon offsets; (2) a carbon offset market exists, but forest carbon sequestration cannot be used as carbon offsets; and (3) a carbon offset market does not exist. Forests in Taipei (with low carbon emissions) and Kaohsiung (with high carbon emissions) were selected as research sites to explore the benefits of carbon emissions trading and forest carbon sequestration. The results show that CER costs are the lowest in scenario 1 and are the highest in scenario 3. The CER costs of Kaohsiung are higher than those of Taipei. The higher the carbon price, the greater the difference in CER costs between the two cities. Study Implications: The objective of this study was to identify the optimal policy for Taiwan to effectively slow climate change. This study showed that the opening of carbon offset markets and the use of forest carbon sequestration as carbon offsets may prompt regions to increase their forest stock to lower their emission reduction costs. However, achieving 2050 carbon neutral target by solely using forest carbon sequestration is not sufficient in Taiwan.

Culturing reef-building corals on a laboratory dish: a simple experimental platform for stony corals - Shinya Shikina; Tzu-Chieh Lin; Yu-Ling Chu; Yin-Chu Cheng; Yu-En Chang; Naohisa Wada; Sen-Lin Tang; Yoshiyuki Iizuka; Yi-Ling Chiu (Frontiers in Marine Science, 2023)
Development and maintenance of coral reef ecosystems rely on daily micro-biological activities of healthy corals. Although a comprehensive understanding of coral biological properties, as well as factors negatively affecting coral growth, are essential to conserve existing corals, the current lack of a tractable culture and experimental platform has delayed acquisition of such knowledge. Here we show a highly versatile culture system, “coral-on-a-laboratory dish” (CLD), allowing long-term culturing of various corals in plastic/glass Petri dishes with maintenance of their biological properties. Under optimized conditions, coral microcolonies (~5 mm x 5 mm fragments) of Pocillopora damicornis were cultured for several months in dishes with high survivorship and characteristic growth. These microcolonies maintained their biological properties, such as reproduction, skeleton formation, coral-algal symbiosis, ingestion, and digestion. Thus far, CLD has been used to maintain at least 4 other coral species from 4 other families, including the Acroporidae, the Pocilloporidae, the Poritidae, and the Merulinidae for more than 2 months with 100% survivorship. CLD is applicable to a variety of biophysiological studies, including coral-algal symbiosis and impact assessment of marine pollutants, e.g., a sunscreen substance, oxybenzone, and an organic biocide, Irgarol 1051, at cellular-level resolution. The CLD platform, which allows easy and inexpensive coral maintenance in a laboratory incubator, represents a technological breakthrough that will greatly advance coral studies.

Captive Reproductive Behavior, Spawning, and Early Development of White-Barred Goby Amblygobius phalaena (Valenciennes, 1837) and Examined Larval Survival and Viability at Different Water Temperatures and Salinities - Pei-Sheng Chiu; Shine-Wei Ho; Cheng-Hsuan Huang; Yen-Chun Lee; Yu-Hung Lin (Fishes, 2023)
White-barred goby Amblygobius phalaena is a highly valued marine ornamental fish, but its captive reproduction and early life history are poorly understood. In this study, the captive reproductive behavior, early development, and optimal temperature and salinity for the larval survival and viability of A. phalaena were investigated for the first time. Spawning occurred between 11:00 and 13:00, with the breeding pairs naturally spawning 24 times from 1 June 2021 to 30 June 2022. The fecundity ranged from 11,022 to 95,858 eggs per spawning event. Hatching occurred approximately 81 h and 26 min after fertilization at a temperature of 27.0 ± 0.9 °C. Newly hatched larvae had a total length (TL) of 1.91–2.03 mm with 24–26 somites. The larvae transformed into juveniles at 30 days post-hatch. Experiments were conducted at different temperatures (21, 24, 27, 30, and 33 °C) and salinities (18, 24, 30, and 36 ppt) to determine the optimal conditions for larval survival and viability. The results indicate that the most suitable conditions in terms of temperature were in the range of 21–27 °C and 30 ppt for salinity. These findings provide valuable insights for the future development of captive-breeding techniques and the commercial production of other marine ornamental gobies.

Nighttime light perspective in urban resilience assessment and spatiotemporal impact of COVID-19 from January to June 2022 in mainland China - Yaohui Liu; Wenyi Liu; Xinyu Zhang; Yu Lin; Guoqiang Zheng; Zhan Zhao; Hao Cheng; Lutz Gross; Xiaoli Li; Benyong Wei; Fei Su (Urban Climate, 2023)

PKC-δ-dependent mitochondrial ROS attenuation is involved as 9-OAHSA combats lipoapotosis in rat hepatocytes induced by palmitic acid and in Syrian hamsters induced by high-fat high-cholesterol high-fructose diet - Ching-Hui Loh; Wei-Wen Kuo; Shinn-Zong Lin; Cheng-Yen Shih; Pi-Yu Lin; Jiro Hasegawa Situmorang; Chih-Yang Huang (Toxicology and Applied Pharmacology, 2023)

Distribution of hydrogen isotope in the soil around the Qinshan Nuclear Power Plant - Jie Liang; Wen-yu Cheng; Jing-lin Li; Xiao-chong Xue; Ke Deng; Chao-fei Liang; Lin Du; Qin Zhang; Wei Liu (Journal of Environmental Radioactivity, 2023)

Variation in microbiological heterogeneity in Chinese strong-flavor Baijiu fermentation for four representative varieties of sorghum - Mao-Ke Liu; Yu-Ming Tang; Cheng-Yuan Liu; Xin-Hui Tian; Ji-Wei Zhang; Xiao-Li Fan; Kai-Feng Jiang; Xian-Lin Ni; Xin-Yu Zhang (International Journal of Food Microbiology, 2023)

Evaluation of alternative processes of methanol production from CO2: Design, optimization, control, techno-economic, and environmental analysis - Hsuan-Han Chiou; Chi-Jui Lee; Bo-Sheng Wen; Jian-Xun Lin; Cheng-Liang Chen; Bor-Yih Yu (Fuel, 2023)

Swc4 protects nucleosome-free rDNA, tDNA and telomere loci to inhibit genome instability - Yue Pan; Can Hu; Lin-Jun Hou; Yu-Long Chen; Jiantao Shi; Jia-Cheng Liu; Jin-Qiu Zhou (DNA Repair, 2023)

A fractional-order two-surface plasticity model for over-consolidated clays and its application to deep gallery excavation - Wei Cheng; Ren-Peng Chen; Zhen-Yu Yin; Han-Lin Wang; Fan-Yan Meng (Computers and Geotechnics, 2023)

Ganglioside-focused Glycan Array Reveals Abnormal Anti-GD1b Auto-antibody in Plasma of Preclinical Huntington’s Disease - Tien-Wei Lin; Jung-Kai Chang; Yih-Ru Wu; Tsung-Hsien Sun; Yang-Yu Cheng; Chien-Tai Ren; Mei-Hung Pan; Jin-Lin Wu; Kuo-Hsuan Chang; Hwai-I Yang; Chiung-Mei Chen; Chung-Yi Wu; et al. (Molecular Neurobiology, 2023)

Plasma cell-free DNA promise monitoring and tissue injury assessment of COVID-19 - Xin Jin; Yanqun Wang; Jinjin Xu; Yimin Li; Fanjun Cheng; Yuxue Luo; Haibo Zhou; Shanwen Lin; Fei Xiao; Lu Zhang; Yu Lin; Zhaoyong Zhang; et al. (Molecular Genetics and Genomics, 2023)
Coronavirus 2019 (COVID-19) is a complex disease that affects billions of people worldwide. Currently, effective etiological treatment of COVID-19 is still lacking; COVID-19 also causes damages to various organs that affects therapeutics and mortality of the patients. Surveillance of the treatment responses and organ injury assessment of COVID-19 patients are of high clinical value. In this study, we investigated the characteristic fragmentation patterns and explored the potential in tissue injury assessment of plasma cell-free DNA in COVID-19 patients. Through recruitment of 37 COVID-19 patients, 32 controls and analysis of 208 blood samples upon diagnosis and during treatment, we report gross abnormalities in cfDNA of COVID-19 patients, including elevated GC content, altered molecule size and end motif patterns. More importantly, such cfDNA fragmentation characteristics reflect patient-specific physiological changes during treatment. Further analysis on cfDNA tissue-of-origin tracing reveals frequent tissue injuries in COVID-19 patients, which is supported by clinical diagnoses. Hence, our work demonstrates and extends the translational merit of cfDNA fragmentation pattern as valuable analyte for effective treatment monitoring, as well as tissue injury assessment in COVID-19.

Influence of microclimate control on the growth of asparagus under greenhouse in tropical climates - Kuo-An Hung; Yi-Wei Hsu; Yu-Cheng Chen; Tzu-Ping Lin (International Journal of Biometeorology, 2023)

Identification of the spatial patterns and controlling factors of Se in soil and rice in Guangxi through hot spot analysis - Xu Liu; Chaosheng Zhang; Tao Yu; Wenbing Ji; Tiansheng Wu; Xiaoxiong Zhuo; Cheng Li; Bo Li; Lei Wang; Yuxiang Shao; Kun Lin; Xudong Ma; et al. (Environmental Geochemistry and Health, 2023)

Embryonic thermosensitivity and hatchling morphology differ among three species of crocodilians farm-raised in China - Dan Liu; Jia-Tian Chen; Jung-Chien Tsai; Cheng-Wang Li; Chi-Xian Lin; Yan-Fu Qu; Yu Du; Xiang Ji (Aquaculture, 2023)

Identification of soil parent materials in naturally high background areas based on machine learning - Cheng Li; Chaosheng Zhang; Tao Yu; Xudong Ma; Yeyu Yang; Xu Liu; Qingye Hou; Bo Li; Kun Lin; Zhongfang Yang; Lei Wang (Science of The Total Environment, 2023)

Gestational cadmium exposure disrupts fetal liver development via repressing estrogen biosynthesis in placental trophoblasts - Yi-Ting Fu; Jin Zhang; Wei-Bo Liu; Yu-Feng Zhang; Shuang Zhang; Lu-Lu Tan; Qing Lin; Kong-Wen Ou-Yang; Yong-Wei Xiong; Wei Chang; Hao Li; Jun-Ying Yu; et al. (Food and Chemical Toxicology, 2023)

Long-term DEHP/MEHP exposure promotes colorectal cancer stemness associated with glycosylation alterations - Pei-Chun Shih; Hsin-Pao Chen; Ching-Cheng Hsu; Chung-Hsien Lin; Chou-Yuan Ko; Chao-Wen Hsueh; Cheng-Yi Huang; Tian-Huei Chu; Cheng-Chun Wu; Yu-Cheng Ho; Ngoc Uyen Nhi Nguyen; Shih-Chung Huang; et al. (Environmental Pollution, 2023)

Improved bioremediation of PCDD/Fs contaminated soil by mycelium-free liquids induced by agro-industrial residues - Chih-Yu Cheng; Zhi-Feng Zhang; Acharee Kaewlaoyoong; Jing-Ting Huang; Nicholas Kiprotich Cheruiyot; Chitsan Lin; Hung-Chou Huang (Bioresource Technology Reports, 2023)

Diffusion mechanism of deep shale gas and its carbon isotope fractionation: a combined simulated and mathematical analysis - Yu Zou; Guojian Wang; Cheng Tao; Rui Zhou; Shangqing Zhang; Dongna Liu; Xiaohui Lin; Xuying Zheng (Geosciences Journal, 2023)

Improving Aquaculture Water Quality Using Dual-Input Fuzzy Logic Control for Ammonia Nitrogen Management - Hung-Chih Li; Ker-Wei Yu; Chang-Hua Lien; Chitsan Lin; Cheng-Ruei Yu; Sundarapandian Vaidyanathan (Journal of Marine Science and Engineering, 2023)
In this paper, a closed-loop control system using dual-input fuzzy logic theory is proposed to improve the water quality of aquaculture. The new closed-loop control system is implemented on a Raspberry-Pi-embedded platform using Python programming. The proposed closed-loop control system integrates an RS485 function, a database transfer module, a simulating variable group function, and a trigger function import to achieve savings in human resources, power, and water consumption. The proposed closed-loop control system is equipped with an ammonia nitrogen sensor and solenoid valves for the water exchange. The experimental results demonstrate that the intelligent controller can rapidly eliminate ammonia nitrogen within the range of 2.0 ppm and maintain robust control in response to changes in ammonia nitrogen excretion from a school of fish. The experimental results provide insights into the relationship between tank capacity, water exchange solenoid valves, and ammonia nitrogen degradation time, which can be used to optimize aquaculture density and improve industrialization. The experimental results demonstrate that the savings for power and water can be achieved above 95%.

Characteristics and provenances of rare earth elements and Nd isotopes in surface sediments of mangrove wetlands in the Jiulong River Estuary, China - Bo-sen Weng; Rui-an Wan; Rui-lian Yu; Gong-ren Hu; Yu Yan; Cheng-qi Lin; Hua-bin Huang (Environmental Science and Pollution Research, 2023)

Quantum neuronal sensing of quantum many-body states on a 61-qubit programmable superconducting processor - Ming Gong; He-Liang Huang; Shiyu Wang; Chu Guo; Shaowei Li; Yulin Wu; Qingling Zhu; Youwei Zhao; Shaojun Guo; Haoran Qian; Yangsen Ye; Chen Zha; et al. (Science Bulletin, 2023)

Characteristics of changes in volatile organic compounds and microbial communities during the storage of pickles - Xi-han Sun; Xin Qi; Yu-di Han; Zhi-jun Guo; Cheng-bi Cui; Chang-qing Lin (Food Chemistry, 2023)

High fructose-induced skeletal muscle insulin resistance could be alleviated by berberine via AMPD1 and ADSL - Juanjuan Cheng; Xingdong Ma; Guangtao Yan; Qiuxia Yu; Zhen Huang; Guoshu Lin; Mengyao Li; Fengkun Guan; Ziren Su; Fang Yan; Yuhong Liu; Qingfeng Xie (Food and Chemical Toxicology, 2023)

Selective accumulation of ionic nanocrystal H2 storage system as an in situ H2/boric acid nanogenerator fights against ethanol-induced gastric ulcers - Chih-Wei Chou; Wei-Tso Chia; Cam-Hoa Mac; Cheng-Yu Wu; Chun-Chieh Chen; Hsiang-Lin Song; Yi-Hsuan Lin; Yu-Jung Lin; Hsing-Wen Sung (Chemical Engineering Journal, 2023)

QTL-seq and transcriptomic integrative analyses reveal two positively regulated genes that control the low-temperature germination ability of MTP–maize introgression lines - Ru-Yu He; Jun-Jun Zheng; Yu Chen; Ze-Yang Pan; Tao Yang; Yang Zhou; Xiao-Feng Li; Xinyi Nan; Ying-Zheng Li; Ming-Jun Cheng; Yan Li; Yang Li; et al. (Theoretical and Applied Genetics, 2023)

Increased hypertension risk for the elderly with high blood levels of strontium and lead - Jiebao Zhang; Chunfang Xu; Yan Guo; Xingyi Jin; Zi Cheng; Qi Tao; Lin Liu; Rui Zhan; Xuemin Yu; Hongjuan Cao; Fangbiao Tao; Jie Sheng; et al. (Environmental Geochemistry and Health, 2023)

Aestuariibaculum lutulentum sp. nov., a marine bacterium isolated from coastal sediment in Beihai - Jia-Wei Gao; Dong-Yan He; Wen-Wu Zhang; Yu-Ruo Wang; Yue Su; Jun-Jie Ying; Zhi-Cheng Wu; Wu Qu; Lin Xu; Cong Sun (Archives of Microbiology, 2023)

Genomic architecture underlying morphological and physiological adaptation to high elevation in a songbird - Chia‐Wei Lu; Shih‐Ting Huang; Shun‐Jen Cheng; Chen‐Tau Lin; Yu‐Cheng Hsu; Cheng‐Te Yao; Feng Dong; Chih‐Ming Hung; Hao‐Chih Kuo (Molecular Ecology, 2023)
Organisms often acquire physiological and morphological modifications to conquer ecological challenges when colonizing new environments which lead to their adaptive evolution. However, deciphering the genomic mechanism of ecological adaptation is difficult because ecological environments are often too complex for straightforward interpretation. Thus, we examined the adaptation of a widespread songbird—the rufous‐capped babbler ( Cyanoderma ruficeps )—to a relatively simple system: distinct environments across elevational gradients on the mountainous island of Taiwan. We focused on the genomic sequences of 43 birds from five populations to show that the Taiwan group split from its sister group in mainland China around 1–2 million years ago (Ma) and colonized the montane habitats of Taiwan at least twice around 0.03–0.22 Ma. The montane and lowland Taiwan populations diverged with gene flow between them, suggesting strong selection associated with different elevations. We found that the montane babblers had smaller beaks than the lowland ones, consistent with Allen's rule, and identified candidate genes— COL9A1 and SOX11 —underlying the beak size changes. We also found that altitudinally divergent mutations were mostly located in noncoding regions and tended to accumulate in chromosomal inversions and autosomes. The altitudinally divergent mutations might regulate genes related to haematopoietic, metabolic, immune, auditory and vision functions, as well as cerebrum morphology and plumage development. The results reveal the genomic bases of morphological and physiological adaptation in this species to the low temperature, hypoxia and high UV light environment at high elevation. These findings improve our understanding of how ecological adaptation drives population divergence from the perspective of genomic architecture.

Effects of biodegradation, biotoxicity and microbial community on biostimulation of sulfolane - Shao-Heng Chang; Chi-Wen Lin; Yu-Shen Cheng; Shu-Hui Liu (Chemosphere, 2023)

Neurite growth induced by red light-caused intracellular reactive oxygen species production through cytochrome c oxidase activation - Yu-Chiu Kao; Guan-Yun Lin; Ji-Yen Cheng; Chau-Hwang Lee (Journal of Photochemistry and Photobiology B: Biology, 2023)

Eicosane-based thermo-conductive phase change composite for efficient capture solar energy and using in real-environment as power source - Linhong Li; Maohua Li; Yue Qin; Yapeng Chen; Wen Dai; Zhenbang Zhang; Xiangdong Kong; Ping Gong; Yandong Wang; Rongjie Yang; Bo Wang; Tao Cai; et al. (Chemical Engineering Journal, 2023)

α7 nicotinic acetylcholine receptor agonist improved brain injury and impaired glucose metabolism in a rat model of ischemic stroke - Ya-Yu Wang; Shih-Yi Lin; Cheng-Yi Chang; Chih-Cheng Wu; Wen-Ying Chen; Wei-Chi Huang; Su-Lan Liao; Wen-Yi Wang; Chun-Jung Chen (Metabolic Brain Disease, 2023)

Effectiveness of Combined Exercise and Physiotherapy Intervention in Improving Functional Activity of Patients with Knee Osteoarthritis in Muslim Pray Movements - Rakhmad Rosadi; Po-Ting Wu; Yu-Lin You; Li-Chieh Kuo; Cheng-Feng Lin (Journal of Medical and Biological Engineering, 2023)

Paper-based analytical device coupled with Bi-MOF: Electric field amplification and fluorescence sensing of glyphosate - Chao-Qun Wan; Yue-Hong Pang; Qiu-Yu Yang; Cheng-Lin Yang; Xiao-Fang Shen (Analytica Chimica Acta, 2023)

Coenzyme Q0 defeats NLRP3-mediated inflammation, EMT/metastasis, and Warburg effects by inhibiting HIF-1α expression in human triple-negative breast cancer cells - Hsin-Ling Yang; Ping-Yu Lin; Chithravel Vadivalagan; Yi-An Lin; Kai-Yuan Lin; You-Cheng Hseu (Archives of Toxicology, 2023)

Investigating the evolution of landscape patterns in historical subdeltas and coastal wetlands in the Yellow River Delta over the last 30 years: A geo-informatics approach - Chao Zhan; Qing Wang; Shanshan Cheng; Lin Zeng; Jiankui Yu; Cheng Dong; Xiang Yu (Frontiers in Marine Science, 2023)
Historically, the river course and coastline of the Yellow River Delta changed frequently, and many studies focused on these change trends and their driving forces. Few studies have explored the influence of historical river channels and historical coastlines on the response of modern landscape patterns. This study examines the impact of channel migration and coastline evolution on the modern landscape pattern of historical subdeltas and coastal wetlands, utilizing a combination of Geo-informatics and Remote Sensing images in 1989, 1998, 2009, and 2016. The results showed that: (1) Subdeltaic landscapes changed from 1998 to 2016, with slight changes in most landscape types in the Ancient Qing Shui Course Subdelta (AQSD), an increase in building sites by 17% in the Zhimai Course Subdelta (ZMSD), a decrease in the proportion of Phragmites/cogongrass communities by 15.8% in the Diao Kou Course Subdelta (DKSD), and domination by natural landscapes in the Modern Qing Shui Course Subdelta (MQSD). (2) Coastal wetlands also experienced changes, with an increase in cultivated land to 60% in the coastal wetlands of CWI, a decline in natural landscapes, and an increase in artificial landscapes in the coastal wetlands of CWII and CWIII, and domination by natural landscapes but an increase in salt fields and culture ponds by 3.45% in the coastal wetlands of CWIV. (3) Channel migration and coastline evolution influenced the direction of landscape succession, causing the landscape-type centroids in the entire delta to move eastward or northward. (4) Throughout the delta, the human tendency to live by rivers was observed. This was due to the availability of freshwater from these rivers, which led to the expansion of inhabited areas and man-made water bodies along the river banks. Channel migration and coastline evolution aggravated the salinization of coastal wetlands and promoted the salt industry and aquaculture in some estuaries of the Yellow River. In general, human activities play a dominant role in shaping the landscape pattern in the Yellow River Delta, but they were largely restricted to historical channel migration and historical coastline evolution.

Diverse alkaloids from the aerial parts of Aconitum carmichaelii and antiproliferative activity of costemline via inhibiting SIRT1/ROCK1/P-STAT3 pathways - Yin-Lin Zhou; Duan-Na Zhang; Ji-Xu Qiao; Jing Wu; Yong-Ming Yan; Zhi-Xing Cao; Cheng Peng; Yu-Zhu Tan (Phytochemistry, 2023)

Flow measurement in open channels using imaging techniques in conjunction with a convolutional neural network - Hao-Che Ho; Yu-Wei Chiu; Ting-Yu Chen; Yen-Cheng Lin (Journal of Hydrology, 2023)

Secondary pollution of microplastic hetero-aggregates after chlorination: Released contaminants rarely re-adsorbed by the second-formed hetero-aggregates - Yan Jin; Minghui Li; Feiyong Chen; Lin Wang; Lijie Zhang; Zhigang Yang; Ning Wang; Jie Fu; Yang Yu; Xiaoxiang Cheng; Daoji Wu (Journal of Hazardous Materials, 2023)

Fouling characteristic of reverse osmosis membrane for reclaimed water treatment operating under cold winter condition - Zi-Hao Li; Guo-Wei Ni; Jin-Long Wang; Lin Zhou; Qiang Yang; Pei-Zhuo Li; Ai-Li Gao; Tong Yu; Li-Hua Cheng; Xue-Jun Bi (Desalination, 2023)

Nanosphere-structured hierarchically porous PVDF-HFP fabric for passive daytime radiative cooling via one-step water vapor-induced phase separation - Ningbo Cheng; Dongyang Miao; Chao Wang; Yanyan Lin; Aijaz Ahmed Babar; Xianfeng Wang; Zhaohui Wang; Jianyong Yu; Bin Ding (Chemical Engineering Journal, 2023)

Effects of demineralization mode and particle size of allogeneic bone powder on its physical and chemical properties - Kun-xiu Song; Shao-lin Ji; Yong-jie Zhao; Hao-ran Zhang; Rong-xing Ma; Jing-yu Zhang; Yong-cheng Hu (Cell and Tissue Banking, 2023)

Rapid shifts in thermal reaction norms and tolerance of brooded coral larvae following parental heat acclimation - Lei Jiang; Cheng‐Yue Liu; Guoxin Cui; Lin‐Tao Huang; Xiao‐Lei Yu; You‐Fang Sun; Hao‐Ya Tong; Guo‐Wei Zhou; Xiang‐Cheng Yuan; Yi‐Si Hu; Wen‐Liang Zhou; Manuel Aranda; et al. (Molecular Ecology, 2023)
Thermal priming of reef corals can enhance their heat tolerance; however, the legacy effects of heat stress during parental brooding on larval resilience remain understudied. This study investigated whether preconditioning adult coral Pocillopora damicornis to high temperatures (29°C and 32°C) could better prepare their larvae for heat stress. Results showed that heat‐acclimated adults brooded larvae with reduced symbiont density and shifted thermal performance curves. Reciprocal transplant experiments demonstrated higher bleaching resistance and better photosynthetic and autotrophic performance in heat‐exposed larvae from acclimated adults compared to unacclimated adults. RNA‐seq revealed strong cellular stress responses in larvae from heat‐acclimated adults that could have been effective in rescuing host cells from stress, as evidenced by the widespread upregulation of genes involved in cell cycle and mitosis. For symbionts, a molecular coordination between light harvesting, photoprotection and carbon fixation was detected in larvae from heat‐acclimated adults, which may help optimize photosynthetic activity and yield under high temperature. Furthermore, heat acclimation led to opposing regulations of symbiont catabolic and anabolic pathways and favoured nutrient translocation to the host and thus a functional symbiosis. Notwithstanding, the improved heat tolerance was paralleled by reduced light‐enhanced dark respiration, indicating metabolic depression for energy saving. Our findings suggest that adult heat acclimation can rapidly shift thermal tolerance of brooded coral larvae and provide integrated physiological and molecular evidence for this adaptive plasticity, which could increase climate resilience. However, the metabolic depression may be maladaptive for long‐term organismal performance, highlighting the importance of curbing carbon emissions to better protect corals.

3D printing titanium dioxide-acrylonitrile-butadiene-styrene (TiO2-ABS) composite membrane for efficient oil/water separation - Lei Han; Liguo Shen; Hongjun Lin; Zhengyi Huang; Yanchao Xu; Renjie Li; Bisheng Li; Cheng Chen; Wei Yu; Jiaheng Teng (Chemosphere, 2023)

Development of innovative marker detection methods for high-fertility ducks (Anas plastyrhynchos) - Hsiu-Lin Huang; Hsiao-Lung Liu; Yu-Shin Cheng (Theriogenology, 2023)

Ambient relative humidity-dependent obstructive sleep apnea severity in cold season: A case-control study - Kuan-Jen Bai; Wen-Te Liu; Yuan-Chien Lin; Yansu He; Yueh-Lun Lee; Dean Wu; Ta-Yuan Chang; Li-Te Chang; Chun-Yeh Lai; Cheng-Yu Tsai; Kian Fan Chung; Kin-Fai Ho; et al. (Science of The Total Environment, 2023)

ARSCP: An antimicrobial residue surveillance cloud platform for animal-derived foods - Jun-Jun Yu; Ya-Lin Hu; Cheng-Zheng Liu; Shuai-Bin Wu; Zi-Jian Zheng; Ze-Hua Cui; Li Chen; Tian Wei; Shi-Kai Sun; Jun Ning; Xiang Wen; Qiu-Yue Diao; et al. (Science of The Total Environment, 2023)

Modeling of an integrated H2S/NH3 scrubber and regeneration columns for coke oven gas purification - Hao-Jen Pan; Ming-Chun Fang; Jeffrey D. Ward; Hao-Yeh Lee; Hsun-Yu Lin; Cheng-Ting Hsieh; Chih-Lung Lee; Tzu-Hsien Huang; Yu-Chen Hsieh; Shih-Chieh Lin; Wei-Ti Chou (Journal of Cleaner Production, 2023)

Universal correlation for falling film evaporation on a horizontal plain tube - Hao-Yu Lin; Muneeshwaran M; Cheng-Min Yang; Kashif Nawaz; Chi-Chuan Wang (International Journal of Refrigeration, 2023)

Tourists' preference for colors of forest landscapes and its implications for forest landscape planning policies - Wan-Yu Liu; Chen Tsao; Chun-Cheng Lin (Forest Policy and Economics, 2023)

Effect of species, muscle location, food processing and refrigerated storage on the fish allergens, tropomyosin and parvalbumin - Chia-Lin Tsai; Kristy Perng; Yu-Chen Hou; Cheng-Jou Shen; I-Ning Chen; Yi-Tien Chen (Food Chemistry, 2023)

Using transcriptomics to reveal the molecular mechanism of higher alcohol metabolism in Saccharomyces cerevisiae - Danyao Cui; Ling Liu; Xiaoyuan Zhang; Liangcai Lin; Xin Li; Ting Cheng; Chunhui Wei; Yu Zhang; Zheng Zhou; Wei Li; Cuiying Zhang (Food Bioscience, 2023)

The effect of isovitexin on lipopolysaccharide-induced renal injury and inflammation by induction of protective autophagy - Chiao-Yun Tseng; Pei-Rong Yu; Cheng-Chin Hsu; Hui-Hsuan Lin; Jing-Hsien Chen (Food and Chemical Toxicology, 2023)

In vitro and in vivo anti-tumor activity of Antrodia salmonea against twist-overexpressing HNSCC cells: Induction of ROS-mediated autophagic and apoptotic cell death - Hsin-Ling Yang; Yi-An Lin; Sudhir Pandey; Jiunn-Wang Liao; Tzong-Der Way; Yu-lyu Yeh; Siang-Jyun Chen; You-Cheng Hseu (Food and Chemical Toxicology, 2023)

A conductive hydrogel based on nature polymer agar with self-healing ability and stretchability for flexible sensors - Zhen Nie; Kelin Peng; Lizhi Lin; Jueying Yang; Zhekun Cheng; Qiang Gan; Yu Chen; Changgen Feng (Chemical Engineering Journal, 2023)

Regulating desolvation and homogenized ion flux towards highly reversible dendrite-free zinc anode - Xin Qi; Fuli Xie; Yu-Ting Xu; Hai Xu; Cheng-Lin Sun; Sheng-Han Wang; Jian-Yong Hu; Xiao-Feng Wang (Chemical Engineering Journal, 2023)

Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival - Jialiang Yang; Yuhong Chen; Tongdan Zou; Bai Xue; Fang Yang; Xiangzhou Wang; Yibo Huo; Boyun Yan; Yuxia Xu; Shiyu He; Yi Yin; Jing Wang; et al. (Science China Life Sciences, 2023)

Attentional focus effect on dual-task walking in Parkinson’s disease with and without freezing of gait - Yu-An Chen; Ruey-Meei Wu; Chen-Hsing Sheu; Chin-Hsien Lin; Cheng-Ya Huang (GeroScience, 2023)

Impacts of 2 and 4°C global warmings on extreme temperatures in Taiwan - I‐Chun Tsai; Pei‐Rong Hsieh; Chao‐Tzuen Cheng; Yu‐Shiang Tung; Lee‐Yaw Lin; Huang‐Hsiung Hsu (International Journal of Climatology, 2023)
Extreme temperatures were considered natural hazards because they could increase morbidity and mortality. Understanding the extreme temperature changes at different warming levels is crucial to climate change mitigation and adoption for human health. This study projected climate change effects on the intensity, occurrence, and duration of extreme temperatures in Taiwan with 2 and 4°C global warming scenarios using the Weather Research and Forecasting model. The future climate simulations were conducted with the pseudo‐global warming approach, and the future climate changes were obtained from the ensemble mean of simulations in the Coupled Model Intercomparison Project 5. The simulated daily mean temperature increased by 1.40 and 3.09°C under 2 and 4°C global warmings. In a warming world, the daily maximum temperature was projected to increase by 1.35–3.00°C, whereas the daily minimum temperature was even higher, leading to weaker diurnal temperature variation in most regions. The simulation results show that intensified heatwaves with frequent and prolonged durations become par for the course, whereas extremely cold days disappear gradually. The occurrence of heatwaves in the future is projected to be five times that in the current climate. Comparing the global warming impacts over different land‐use types, the heatwave occurrence over urban areas rose more quickly than over other land‐use types; forests are less vulnerable to global warming. On the contrary, the changes in extremely cold days over urban areas were weaker than over other land‐use types. Overall, the effects of global warming on temperature revealed that extreme events were more severe with increased temperature than with the mean state of air temperature. Nonlinear behaviours indicated that global warming should be limited to 2°C, and the additional 2°C warming (from 2 to 4°C) should be addressed carefully.

Evaluating the release and metabolism of ricinine from castor cake fertilizer in soils using a LC-QTOF/MS coupled with SIRIUS workflow - Kai-Xuan Zheng; Cheng-Hua Liu; Sichao Wang; Yu-Min Tzou; Chih-Min Chiang; Shiou-Ruei Lin; Hsiao-Ying Yang; Jerry J. Wu; Ya-Hui Chuang (Chemosphere, 2023)

Mapping Chinese annual gross primary productivity with eddy covariance measurements and machine learning - Xian-Jin Zhu; Gui-Rui Yu; Zhi Chen; Wei-Kang Zhang; Lang Han; Qiu-Feng Wang; Shi-Ping Chen; Shao-Min Liu; Hui-Min Wang; Jun-Hua Yan; Jun-Lei Tan; Fa-Wei Zhang; et al. (Science of The Total Environment, 2023)

Corrigendum to “Comparative efficacy of omega-3 polyunsaturated fatty acids on major cardiovascular events: A network meta-analysis of randomized controlled trials” [Progress in Lipid Research. 2022 Oct 28;88:101196. doi: 10.1016/j.plipres.2022.101196] - Bo Yang; Ping-Tao Tseng; Xiang Hu; Bing-Yan Zeng; Jane Pei-Chen Chang; Yang Liu; Wei-Jie Chu; Shuang-Shuang Zhang; Zhi-Liang Zhou; Chih-Sheng Chu; Cheng-Ho Chang; Yu-Kang Tu; et al. (Progress in Lipid Research, 2023)

Microbiome reengineering by four environmental factors for the rapid biodegradation of trichloroethylene - Yu-Hsuan Cheng; Shu-Chi Chang; Yan-Lin Lai; Chung-Chi Hu (Journal of Environmental Management, 2023)

Two-stage dynamic data envelopment analysis measuring the overall efficiency and productivity changes of industry and agriculture in EU countries - Ching-Cheng Lu; I-Fang Lin; Tai-Yu Lin; Yung-ho Chiu (Journal of Cleaner Production, 2023)

The largest rock avalanche in China at Iymek, Eastern Pamir, and its spectacular emplacement landscape - An-Wen Shi; Yu-Feng Wang; Qian-Gong Cheng; Qi-Wen Lin; Tian-Hua Li; Bernd Wünnemann (Geomorphology, 2023)

Identification of ISG15 in golden pompano, Trachinotus ovatus, and its role in virus and bacteria infections - Lin Huang; Yuan Cheng; Shuyu Han; Mingzhu Liu; Qing Yu; Hongling Wei; Jinzhao He; Pengfei Li (Fish & Shellfish Immunology, 2023)

Prenatal exposure to phthalates and polybrominated diphenyl ethers on neonatal health: A birth cohort study in Guangxi, China - Bo Qian; Zhao-xuan Zheng; Lei Yang; Cheng-qiang Wang; Yu-Chun Lin; Zhong-Ning Lin (Environmental Research, 2023)

Using cluster algorithms with a machine learning technique and PMF models to quantify local-specific origins of PM2.5 and associated metals in Taiwan - Chin-Yu Hsu; Jhy-Charm Soo; Sheng-Lun Lin; Chih-Da Wu; Kai Hsien Chi; Wen-Chang Hsu; Chun-Chieh Tseng; Yu-Cheng Chen (Environmental Pollution, 2023)

Intimate interaction of TFSI− anions with MoO3−x oxygen vacancies boost ionic conductivity of cathode-supported solid polymer electrolyte - Rohan Paste; Chintam Hanmandlu; Po-Yu Su; Cheng-Hung Hou; Hsin-An Chen; Chun-Wei Pao; Jing-Jong Shyue; Kuei-Hsien Chen; Heng-Liang Wu; Hong-Cheu Lin; Chih Wei Chu (Chemical Engineering Journal, 2023)

The coupling of persulfate activation and membrane separation for the effective pollutant degradation and membrane fouling alleviation - Mingzhu Zhou; Junjie Chen; Shuning Yu; Binghong Chen; Cheng Chen; Liguo Shen; Bisheng Li; Hongjun Lin (Chemical Engineering Journal, 2023)

Intelligent films of marine polysaccharides and purple cauliflower extract for food packaging and spoilage monitoring - Han-Lun Huang; I-Lin Tsai; Chi Lin; Yu-Hao Hang; Yi-Cheng Ho; Min-Lang Tsai; Fwu-Long Mi (Carbohydrate Polymers, 2023)

Hydroxychloroquine repairs burn damage through the Wnt/β-catenin pathway - Sheau-Chung Tang; Chun-Te Lu; Jiunn-Liang Ko; Cheng-Hui Lin; Yu-Ping Hsiao (Chemico-Biological Interactions, 2023)

Combined population transcriptomic and genomic analysis reveals cis-regulatory differentiation of non-coding RNAs in maize - Jiawen Lu; Sihan Zhen; Jie Zhang; Yuxin Xie; Cheng He; Xiaoli Wang; Zheyuan Wang; Song Zhang; Yongxiang Li; Yu Cui; Guoying Wang; Jianhua Wang; et al. (Theoretical and Applied Genetics, 2023)

Equilibrative Nucleoside Transporter 1 is a Target to Modulate Neuroinflammation and Improve Functional Recovery in Mice with Spinal Cord Injury - Kuan-Yu Chen; Chiao-Shin Lu; Cheng-Yoong Pang; Chin-Jui Ho; Kuo-Chen Wu; Hsiu-Wei Yang; Hsin-Lin Lai; Yijuang Chern; Chun-Jung Lin (Molecular Neurobiology, 2023)

Gas-phase and PM2.5-bound phthalates in nail salons: characteristics, exposure via inhalation, and influencing factors - Chia-Ling Chang; Hui-Tzu Chen; Chung-Yu Chen; En-Yu Chen; Kuan-Ting Lin; Chien-Cheng Jung (Environmental Science and Pollution Research, 2023)

Mesenchymal Stem Cell Secreted-Extracellular Vesicles are Involved in Chondrocyte Production and Reduce Adipogenesis during Stem Cell Differentiation - Yu-Chen Tsai; Tai-Shan Cheng; Hsiu-Jung Liao; Ming-Hsi Chuang; Hui-Ting Chen; Chun-Hung Chen; Kai-Ling Zhang; Chih-Hung Chang; Po-Cheng Lin; Chi-Ying F. Huang (Tissue Engineering and Regenerative Medicine, 2022)
Background: Extracellular vesicles (EVs) are derived from internal cellular compartments, and have potential as a diagnostic and therapeutic tool in degenerative disease associated with aging. Mesenchymal stem cells (MSCs) have become a promising tool for functional EVs production. This study investigated the efficacy of EVs and its effect on differentiation capacity. Methods: The characteristics of MSCs were evaluated by flow cytometry and stem cell differentiation analysis, and a production mode of functional EVs was scaled from MSCs. The concentration and size of EVs were quantitated by Nanoparticle Tracking Analysis (NTA). Western blot analysis was used to assess the protein expression of exosome-specific markers. The effects of MSC-derived EVs were assessed by chondrogenic and adipogenic differentiation analyses and histological observation. Results: The range of the particle size of adipose-derived stem cells (ADSCs)- and Wharton’s jelly -MSCs-derived EVs were from 130 to 150 nm as measured by NTA, which showed positive expression of exosomal markers. The chondrogenic induction ability was weakened in the absence of EVs in vitro . Interestingly, after EV administration, type II collagen, a major component in the cartilage extracellular matrix, was upregulated compared to the EV-free condition. Moreover, EVs decreased the lipid accumulation rate during adipogenic induction. Conclusion: The results indicated that the production model could facilitate production of effective EVs and further demonstrated the role of MSC-derived EVs in cell differentiation. MSC-derived EVs could be successfully used in cell-free therapy to guide chondrogenic differentiation of ADSC for future clinical applications in cartilage regeneration.

Orientin downregulating oxidative stress-mediated endoplasmic reticulum stress and mitochondrial dysfunction through AMPK/SIRT1 pathway in rat nucleus pulposus cells in vitro and attenuated intervertebral disc degeneration in vivo - Zhao Zhang; Jingtao Wu; Cheng Teng; Jinquan Wang; Jiapei Yu; Chen Jin; Libo Wang; Long Wu; Zhen Lin; Ziping Yu; Zhongke Lin (Apoptosis, 2022)

First report of leaf blight on Panax notoginseng caused by Pestalotiopsis trachycarpicola in China - Cheng Zhong Lan; Xiong Lin; Yu Li Dai; Lin Gan; Xiao Fei Liu; Hong Chun Ruan; Xiu Juan Yang (Journal of Plant Pathology, 2022)

Protective effect of ginsenoside Rd on military aviation noise-induced cochlear hair cell damage in guinea pigs - Xue-min Chen; Yu-hui Liu; Shuai-fei Ji; Xin-miao Xue; Lin-lin Wang; Min Zhang; Yao-ming Chang; Xiao-cheng Wang (Environmental Science and Pollution Research, 2022)

A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer - Chang Gong; Ziliang Cheng; Yaping Yang; Jun Shen; Yingying Zhu; Li Ling; Wanyi Lin; Zhigang Yu; Zhihua Li; Weige Tan; Chushan Zheng; Wenbo Zheng; et al. (Science China Life Sciences, 2022)

The Influence of the Rotary Speed of a Microwave Applicator on Hard-Rock Fracturing Effect - Xia-ting Feng; Shi-ping Li; Cheng-xiang Yang; Feng Lin; Tian-yang Tong; Xiang-xin Su; Jiu-yu Zhang (Rock Mechanics and Rock Engineering, 2022)

Impact of Petroleum Contamination on the Structure of Saline Soil Bacterial Communities - Ying Zhang; Xiaojie Sun; Cheng Qian; Lin Li; Xiufang Shang; Xinfeng Xiao; Yu Gao (Current Microbiology, 2022)

Behavioral and transcriptomic changes in butenolide treated larvae of the cosmopolitan fouling bryozoan Bugulina (Bugula) neritina - Jin-You Liang; Yi-Fan Cheng; Xiao-Lin Huang; Ying Xu; Yue Him Wong; Yu Zhang (Frontiers in Marine Science, 2022)
The arborescent bryozoan Bugulina neritina is a cosmopolitan fouling species in sub-tropical to sub-temperate waters. The butenolide compound 5-octylfuran-2(5H)-one (hereafter named butenolide) reportedly inhibits larval settlement of B. neritina , but its effect on the larval behavioral and transcriptomic responses remained unclear. We report that 10 μg mL -1 or higher concentration of butenolide and/or prolonged treatment (10 h or longer) resulted in significant increase in larval mortality and prominent spiral larval swimming behavior. The transcriptomic analyses not only revealed up-regulation of typical stress-related protein genes in response to 10 mg mL -1 butenolide treatment, but also indicated up-regulation of mucin , synaptic genes and nitric oxide signaling genes. In addition, the expression of developmental genes and lipid biosynthesis genes were also affected. Overall, our larval behavior and transcriptome analyses reflected the impact of butenolide on the metabolism, neuronal and molecular signaling in B. neritina larvae.

Associations of metal profiles in blood with thyroiditis: a cross-sectional study - Yaosheng Luo; Huixian Zeng; Yanshi Ye; Genfeng Yu; Cheng Song; Siyang Liu; Xingying Chen; Yuqi Jiang; Hualin Duan; Yue Li; Shengqing He; Zhi Chen; et al. (Environmental Science and Pollution Research, 2022)
Autoimmune thyroiditis (AIT) is increasingly common, and serological markers include thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb). To determine if selected metals influence thyroiditis antibody positivity, this cross-sectional study investigated associations between metals and thyroiditis antibody status. Healthy individuals ( n = 1104) completed a questionnaire and underwent checkups of anthropometric parameters, thyroid function status, and levels of seven metals in blood (magnesium, iron, calcium, copper, zinc, manganese, and lead). Associated profiles of glyco- and lipid metabolism were also established. Logistic regression and restricted cubic spline (RCS) regression analysis were applied to adjudge associations between metals and TPOAb and TgAb status. It was found that, after adjusting for likely cofounding factors, participants with antibody positivity had significantly lower serum concentrations of magnesium and iron. When serum magnesium levels were analyzed in quartiles, the odds ratios of quartile 4 were 0.329–fold (95% confidence interval (CI): 0.167–0647) and 0.259-fold (95% CI 0.177–0.574) that of quartile 1 regarding TPOAb and TgAb positivity ( P = 0.004, 0.003). After adjustment, the RCS analysis detected nonlinear associations between iron and TPOAb and TgAb positivity ( P < 0.01, both). In stratified analyses, these associations regarding magnesium and iron remained for women of reproductive age, but not for postmenopausal women and men. We conclude that lower serum levels of magnesium and iron are associated with incremental positivity of thyroiditis antibodies and may be among the most important metals contributing to AIT in women of reproductive age.

Surfactin isoforms isolated from a mushroom derived Bacillus halotolerans DMG-7-2 - Guo-Feng Zhou; Lin Yang; Shu-Hua Zhang; Yi Wang; Yu Yang; Rui Xu; Xue Zhao; Dan Nie; Junjie Shan; Cheng-Bin Cui; Chang-Wei Li (Natural Product Research, 2022)

Gregarious larval settlement mediates the responses of new recruits of the reef coral Acropora austera to ocean warming and acidification - Lei Jiang; Yu-Yang Zhang; Cheng-Yue Liu; Lin-Tao Huang; Hao-Ya Tong; Guo-Wei Zhou; Ming-Lan Guo; Tao Yuan; Hui Huang (Frontiers in Marine Science, 2022)
Gregarious larval settlement represents an important window for chimera formation in reef corals, yet it remains largely unknown how aggregated settlement and early chimerism could modify the performance and responses of coral recruits under elevated temperature and p CO 2 . In this study, single and aggregated recruits of the broadcast spawning coral Acropora austera were exposed to contrasts of two temperatures (28 versus 30.5°C) and p CO 2 levels (~500 versus 1000 μatm) for two weeks, and algal symbiont infection success, survivorship and growth were assessed. Results showed that symbiont infection success was mainly affected by temperature and recruit type, with reduced symbiont infection at increased temperature and consistently higher infection success in chimeric recruits compared to single recruits. Furthermore, although chimeric recruits with larger areal size had significantly higher survivorship in all treatments, the polyp-specific growth rates were considerably lower in chimeric entities than individual recruits. More importantly, the recruit type significantly influenced the responses of recruit polyp-specific growth rates to elevated temperature, with chimeras exhibiting lowered skeletal lateral growth under elevated temperature. These results demonstrate the benefits and costs associated with gregarious larval settlement for juvenile corals under ocean warming and acidification, and highlight the ecological role of larval settlement behavior in mediating the responses of coral recruits to climate change stressors.

Horizontal and vertical heterogeneity of sediment microbial community in Site F cold seep, the South China Sea - Xinyi Zhai; Xiaochong Shi; Haojin Cheng; Peng Yao; Bin Zhao; Lin Chen; Jiwen Liu; Lei Cao; Minxiao Wang; Lulu Fu; Xiao-Hua Zhang; Min Yu (Frontiers in Marine Science, 2022)
Site F is the most vigorous cold seep known on the continental slope of the northern South China Sea. Up to now, the microbial community structures in sediments of Site F based on the high-throughput sequencing of the 16S rRNA genes have been studied extensively. However, few studies investigated the microbial community structures at fine vertical scales of Site F and control stations outside Site F. In this study, a comprehensive investigation of microbial communities in sediments of Site F along the depths varying from 0 to 24 cm below sea floor (cmbsf) of four sampling sites—SRS (Southern Reduced Sediment), NRS (Northern Reduced Sediment), Control 1 (close to Site F), and Control 2 (far from Site F)—was carried out. The high relative abundances of anaerobic methanotrophic archaea (ANME), Desulfobacterota [sulfate-reducing bacteria (SRB)], and Campylobacteria [sulfur-oxidizing bacteria (SOB)] in SRS and NRS indicated that these two sites were newborn cold seep sites compared with non-seep sites, Control 1, and Control 2. A positive correlation between ANME-1b, ANME-2, and SEEP-SRB and an enrichment of Sulfurovum and Methlomonadaceae were found in the surface sediments of both SRS and NRS, indicating that the processes of anaerobic oxidation of methane (AOM), sulfur oxidation, and sulfate reduction might occur in seep sites. SRS was enriched with ANME-1b and SEEP-SRB2 with a proposed sulfate-methane transition zone (SMTZ) approximately located at 8 cmbsf. The high abundance of ANME in SRS may due to the high concentration of methane. NRS was enriched with ANME-2, Desulfatiglans , Sulfurovum , and Methanosarcinaceae with a proposed SMTZ at about 10 cmbsf. According to the analyses of microbial community structure and environmental factors, NRS could be described as a notable cold seep reduced sediment site with low sulfate and high H 2 S that nourished abundant SEEP-SRB1, ANME-2, Methanosarcinales , and Sulfurovum , which showed similar distribution pattern. Our study expands the current knowledge on the differences of microbial communities in cold seep sites and non-seep sites and sheds light on the horizontal and vertical heterogeneity of sediment microbial community in Site F.

Isolation and identification of two new sargentodoxosides from Sargentodoxa cuneata and their agonistic effects against FXR - Wen Zhang; Cheng-Peng Sun; Yu-Lin Peng; Wen-Yu Zhao; Zheng-Yue Wang; Jing Ning; Xia Lv; Zhen-Long Yu; Shuang Zhou; Wei Peng; Bang-Jiang Fang; Xiao-Chi Ma (Natural Product Research, 2022)

Correction to: Matrine Treatment Blocks NogoA-Induced Neural Inhibitory Signaling Pathway in Ongoing Experimental Autoimmune Encephalomyelitis - Quan-Cheng Kan; Hui-Jun Zhang; Yuan Zhang; Xing Li; Yu-Ming Xu; Rodolfo Thome; Ming-Liang Zhang; Nan Liu; Yao-Juan Chu; Guang-Xian Zhang; Lin Zhu (Molecular Neurobiology, 2022)

Investment Feasibility Analysis of Large Submersible Cage Culture in Taiwan: A Case Study of Snubnose Pompano (Trachinotus anak) and Cobia (Rachycentron canadum) - Hsun-Yu Lan; Farok Afero; Cheng-Ting Huang; Bo-Ying Chen; Po-Lin Huang; Yen-Lung Hou (Fishes, 2022)
Onshore farming for premium aquaculture is under scrutiny and criticism partially due to possible causes of adverse environmental impacts on other resource users and the surrounding environment. The best alternative to preventing or minimizing these impacts is to utilize open seawater by large submersible cage culture. The current operation in Taiwan has demonstrated that the culture operation is technically feasible but economically demanding because of high capital and operating costs. Therefore, this study conducted an economic analysis of the expansion of large submersible cage culture by selecting two premium species of snubnose pompano (Trachinotus anak) and cobia (Rachycentron canadum) and examined the profitability of large submersible cage culture investment. This study found that the current operation of four-unit cages highlighted a negative net present value and internal rate of return with a payback period of over ten and six years, respectively. Large submersible cage culture can be financially profitable when its operation unit expands from 8 to 24 units. Increasing unit cages to eight incurred a gross margin of 17.09%, BCR 1.21, with a payback period of 5.36 years. Expanding the operation to 24-unit cages was a potentially lucrative investment with a gross margin of 18.51%, BCR 1.23, PI 2.15, internal rate of return of 20.84%, and a payback period of 3.55 years. Sensitivity analyses revealed that market price and survival rate significantly impact the profitability of large submersible cage culture. Finally, it is suggested that producers could invest in 8-unit cages and maintaining the survival rate of snubnose pompano and cobia at 80% and 40%, respectively.

Lactobacillus plantarum PS128 Promotes Intestinal Motility, Mucin Production, and Serotonin Signaling in Mice - Chih-Ming Chen; Chien-Chen Wu; Chin-Lin Huang; Min-Yu Chang; Shih-Hsuan Cheng; Ching-Ting Lin; Ying-Chieh Tsai (Probiotics and Antimicrobial Proteins, 2022)
Lactobacillus plantarum PS128 has been reported as a psychobiotic to improve mental health through the gut–brain axis in experimental animal models. To explore its mechanism of action in the gut, this study aimed to analyze the effects of L. plantarum PS128 ingestion on naïve and loperamide (Lop)-induced constipation mice. We found that, in the two mouse models, the weight, number, and water content of feces in the L. plantarum PS128 group were higher than those in the vehicle control group. Histological observation revealed that L. plantarum PS128 increased the level of colonic mucins including the major mucin MUC2. In addition, the charcoal meal test showed that L. plantarum PS128 significantly increased the small intestine transit in naïve mice, but not in the Lop-treated mice. Since intestinal serotonin has been found to modulate motility, we further analyzed the expression of genes related to serotonin signal transduction in the small intestine of naïve mice. The results showed that L. plantarum PS128 significantly altered the expression levels of Tph1 , Chga , Slc6a4 , and Htr4 , but did not affect the expression levels of Tph2 , Htr3a , and Maoa . Furthermore, immunohistochemistry revealed that L. plantarum PS128 significantly increased the number of serotonin-containing intestinal cells in mice. Taken together, our results suggest that L. plantarum PS128 could promote intestinal motility, mucin production, and serotonin signal transduction, leading to a laxative effect in mice.

Use of piggyBac Transposon System Constructed Murine Breast Cancer Model for Reporter Gene Imaging and Characterization of Metastatic Tumor Cells - Ying-Ling Chen; Yung-Cheng Wang; Kuei-Yuan Hou; Min-Ying Lin; Yu-Chuan Lin; Hui-Yen Chuang; Yi-Jang Lee (Journal of Medical and Biological Engineering, 2022)

Detection of bloom-forming dinoflagellates Karenia mikimotoi and Prorocentrum donghaiense using qPCR assays - Xiao-Kun Hu; Zhuo-Ru Lin; Qing-Chun Zhang; Fan-Zhou Kong; Jing-Yi Cen; Yu-Lan Zeng; Ren-Cheng Yu (Journal of Applied Phycology, 2022)

Estrogen Deficiency Aggravates Fluoride-Induced Liver Damage and Lipid Metabolism Disorder in Rats - Ya-ming Yu; Bian-hua Zhou; Yi-lin Yang; Cheng-Xiang Guo; Jing Zhao; Hong-wei Wang (Biological Trace Element Research, 2022)

Flow-slide characteristics and failure mechanism of shallow landslides in granite residual soil under heavy rainfall - Hui-lin Bai; Wen-kai Feng; Shuang-quan Li; Long-zhen Ye; Zhong-teng Wu; Rui Hu; Hong-chuan Dai; Yun-peng Hu; Xiao-yu Yi; Peng-cheng Deng (Journal of Mountain Science, 2022)

Identification of PDXDC1 as a novel pleiotropic susceptibility locus shared between lumbar spine bone mineral density and birth weight - Yu-Qian Song; Shi-Di Hu; Xu Lin; Xiang-He Meng; Xiao Wang; Yin-Hua Zhang; Cheng Peng; Rui Gong; Tao Xu; Tong Zhang; Chen-Zhong Li; Dao-Yan Pan; et al. (Journal of Molecular Medicine, 2022)
An increasing number of epidemiological studies have suggested that birth weight (BW) may be a determinant of bone health later in life, although the underlying genetic mechanism remains unclear. Here, we applied a pleiotropic conditional false discovery rate (cFDR) approach to the genome-wide association study (GWAS) summary statistics for lumbar spine bone mineral density (LS BMD) and BW, aiming to identify novel susceptibility variants shared between these two traits. We detected 5 novel potential pleiotropic loci which are located at or near 7 different genes ( NTAN1 , PDXDC1 , CACNA1G , JAG1 , FAT1P1 , CCDC170 , ESR1 ), among which PDXDC1 and FAT1P1 have not previously been linked to these phenotypes. To partially validate the findings, we demonstrated that the expression of PDXDC1 was dramatically reduced in ovariectomized (OVX) mice in comparison with sham-operated (SHAM) mice in both the growth plate and trabecula bone. Furthermore, immunohistochemistry assay with serial sections showed that both osteoclasts and osteoblasts express PDXDC1 , supporting its potential role in bone metabolism. In conclusion, our study provides insights into some shared genetic mechanisms for BMD and BW as well as a novel potential therapeutic target for the prevention of OP in the early stages of the disease development. Key messages We investigated pleiotropy-informed enrichment between LS BMD and BW. We identified genetic variants related to both LS BMD and BW by utilizing a cFDR approach. PDXDC1 is a novel pleiotropic gene which may be related to both LS BMD and BW. Elevated expression of PDXDC1 is related to higher BMD and lower ratio n-6/n-3 PUFA indicating a bone protective effect of PDXDC1.

Bioeconomic evaluation of Eleutheronema tetradactylum farming: a case study in Taiwan - Cheng-Ting Huang; Farok Afero; Fang-Yu Lu; Bo-Ying Chen; Po-Lin Huang; Hsun-Yu Lan; Yen-Lung Hou (Fisheries Science, 2022)

The significance of riparian communities in the energy flow of subtropical stream ecosystems - Yi-Chang Liao; An-Cheng Lin; Han-Ni Tsai; Yu-Ting Yen; Chyng-Shyan Tzeng; Man-Miao Yang; Hsing-Juh Lin (Aquatic Sciences, 2022)

Extensive sequence divergence between the reference genomes of Taraxacum kok-saghyz and Taraxacum mongolicum - Tao Lin; Xia Xu; Huilong Du; Xiuli Fan; Qingwen Chen; Chunyan Hai; Zijian Zhou; Xiao Su; Liquan Kou; Qiang Gao; Lingwei Deng; Jinsheng Jiang; et al. (Science China Life Sciences, 2022)

Assessment of potential sediment disasters and resilience management of mountain roads using environmental indicators - Chao-Yuan Lin; Yuan-Chung Lai; Shao-Wei Wu; Fan-Chung Mo; Cheng-Yu Lin (Natural Hazards, 2022)
In recent years, extreme rainfall events occur frequently, causing serious watershed sediment disasters, destroying mountain roads, and endangering the safety of residents' lives and property. This study aims to deal with the spatial change of potential sediment movement on the road slope pre-disaster and to screen disaster hot spots for early warning and control system. The conceptual model is used to simulate the distribution of primary and/or derived disasters on a watershed scale to assess the impact of sediment disasters caused by heavy rain event. Correlation analysis shows that the models in assessment of primary disaster and derived disaster are significantly correlated with the collapse ratio and disaster ratio, respectively. Since the primary disaster has been considered when calculating the derived disaster risk, the terrain subdivision along Provincial Highway 21 (Tai-21) is extracted to understand the derived sediment disaster on the road slope. The model can effectively evaluate the road sections prone to disasters. According to the risk level, the hot spot of road slope disasters and the management of disaster resilience are determined and can be the reference for disaster prevention and control.

Hippocampal SIRT1-Mediated Synaptic Plasticity and Glutamatergic Neuronal Excitability Are Involved in Prolonged Cognitive Dysfunction of Neonatal Rats Exposed to Propofol - Lin-Hui Ma; Jie Wan; Jing Yan; Ning Wang; Yan-Ping Liu; Hai-Bi Wang; Cheng-Hua Zhou; Yu-Qing Wu (Molecular Neurobiology, 2022)

MoOpy2 is essential for fungal development, pathogenicity, and autophagy in Magnaporthe oryzae - Ying‐Ying Cai; Jing‐Yi Wang; Xi‐Yu Wu; Shuang Liang; Xue‐Ming Zhu; Lin Li; Jian‐Ping Lu; Xiao‐Hong Liu; Fu‐Cheng Lin (Environmental Microbiology, 2022)
Summary The development and pathogenicity of the fungus Magnaporthe oryzae , the causal agent of destructive rice blast disease, require it to perceive external environmental signals. Opy2, an overproduction‐induced pheromone‐resistant protein 2, is a crucial protein for sensing external signals in Saccharomyces cerevisiae . However, the biological functions of the homologue of Opy2 in M. oryzae are unclear. In this study, we identified that MoOPY2 is involved in fungal development, pathogenicity, and autophagy in M. oryzae . Deletion of MoOPY2 resulted in pleiotropic defects in hyphal growth, conidiation, germ tube extension, appressorium formation, appressorium turgor generation, and invasive growth, therefore leading to attenuated pathogenicity. Furthermore, MoOpy2 participates in the Osm1 MAPK pathway and the Mps1 MAPK pathway by interacting with the adaptor protein Mst50. The interaction sites of Mst50 and MoOpy2 colocalized with the autophagic marker protein MoAtg8 in the preautophagosomal structure sites (PAS). Notably, the Δ Moopy2 mutant caused cumulative MoAtg8 lipidation and rapid GFP‐MoAtg8 degradation in response to nitrogen starvation, showing that MoOpy2 is involved in the negative regulation of autophagy activity. Taken together, our study revealed that MoOpy2 of M. oryzae plays an essential role in the orchestration of fungal development, appressorium penetration, autophagy and pathogenesis.

Endosomal sorting complexes required for transport‐0 ( ESCRT ‐0) are essential for fungal development, pathogenicity, autophagy and ER ‐phagy in Magnaporthe oryzae - Li‐Xiao Sun; Hui Qian; Meng‐Yu Liu; Ming‐Hua Wu; Yun‐Yun Wei; Xue‐Ming Zhu; Jian‐Ping Lu; Fu‐Cheng Lin; Xiao‐Hong Liu (Environmental Microbiology, 2022)
Summary Magnaporthe oryzae is an important plant pathogen that causes rice blast. Hse1 and Vps27 are components of ESCRT‐0 involved in the multivesicular body (MVB) sorting pathway and biogenesis. To date, the biological functions of ESCRT‐0 in M. oryzae have not been determined. In this study, we identified and characterized Hse1 and Vps27 in M. oryzae . Disruption of MoHse1 and MoVps27 caused pleiotropic defects in growth, conidiation, sexual development and pathogenicity, thereby resulting in loss of virulence in rice and barley leaves. Disruption of MoHse1 and MoVps27 triggered increased lipidation of MoAtg8 and degradation of GFP‐MoAtg8, indicating that ESCRT‐0 is involved in the regulation of autophagy. ESCRT‐0 was determined to interact with coat protein complex II (COPII), a regulator functioning in homeostasis of the endoplasmic reticulum (ER homeostasis), and disruption of MoHse1 and MoVps27 also blocked activation of the unfolded protein response (UPR) and autophagy of the endoplasmic reticulum (ER‐phagy). Overall, our results indicate that ESCRT‐0 plays critical roles in regulating fungal development, virulence, autophagy and ER‐phagy in M. oryzae .

Prevalence, complete genome, and metabolic potentials of a phylogenetically novel cyanobacterial symbiont in the coral‐killing sponge, Terpios hoshinota - Yu‐Hsiang Chen; Hsing‐Ju Chen; Cheng‐Yu Yang; Jia‐Ho Shiu; Daphne Z. Hoh; Pei‐Wen Chiang; Wenhua Savanna Chow; Chaolun Allen Chen; Tin‐Han Shih; Szu‐Hsien Lin; Chi‐Ming Yang; James Davis Reimer; et al. (Environmental Microbiology, 2022)
Summary Terpios hoshinota is an aggressive, space‐competing sponge that kills various stony corals. Outbreaks of this species have led to intense damage to coral reefs in many locations. Here, the first large‐scale 16S rRNA gene survey across three oceans revealed that bacteria related to the taxa Prochloron , Endozoicomonas , SAR116, Ruegeria , and unclassified Proteobacteria were prevalent in T . hoshinota . A Prochloron ‐related bacterium was the most dominant and prevalent cyanobacterium in T . hoshinota . The complete genome of this uncultivated cyanobacterium and pigment analysis demonstrated that it has phycobiliproteins and lacks chlorophyll b , which is inconsistent with the definition of Prochloron . Furthermore, the cyanobacterium was phylogenetically distinct from Prochloron , strongly suggesting that it should be a sister taxon to Prochloron . Therefore, we proposed this symbiotic cyanobacterium as a novel species under the new genus Candidatus Paraprochloron terpiosi. Comparative genomic analyses revealed that ‘Paraprochloron’ and Prochloron exhibit distinct genomic features and DNA replication machinery. We also characterized the metabolic potentials of ‘Paraprochloron terpiosi’ in carbon and nitrogen cycling and propose a model for interactions between it and T. hoshinota . This study builds a foundation for the study of the T . hoshinota microbiome and paves the way for better understanding of ecosystems involving this coral‐killing sponge.

Downregulated Calcium-Binding Protein S100A16 and HSP27 in Placenta-Derived Multipotent Cells Induce Functional Astrocyte Differentiation - Yu-Che Cheng; Chi-Jung Huang; Wei-Chi Ku; Shu-Lin Guo; Lu-Tai Tien; Yih-Jing Lee; Chih-Cheng Chien (Stem Cell Reviews and Reports, 2022)
Little is known about genes that induce stem cells differentiation into astrocytes. We previously described that heat shock protein 27 (HSP27) downregulation is directly related to neural differentiation under chemical induction in placenta-derived multipotent stem cells (PDMCs). Using this neural differentiation cell model, we cross-compared transcriptomic and proteomic data and selected 26 candidate genes with the same expression trends in both omics analyses. Those genes were further compared with a transcriptomic database derived from Alzheimer’s disease (AD). Eighteen out of 26 candidates showed opposite expression trends between our data and the AD database. The mRNA and protein expression levels of those candidates showed downregulation of HSP27, S100 calcium-binding protein A16 (S100A16) and two other genes in our neural differentiation cell model. Silencing these four genes with various combinations showed that co-silencing HSP27 and S100A16 has stronger effects than other combinations for astrocyte differentiation. The induced astrocyte showed typical astrocytic star-shape and developed with ramified, stringy and filamentous processes as well as differentiated endfoot structures. Also, some of them connected with each other and formed continuous network. Immunofluorescence quantification of various neural markers indicated that HSP27 and S100A16 downregulation mainly drive PDMCs differentiation into astrocytes. Immunofluorescence and confocal microscopic images showed the classical star-like shape morphology and co-expression of crucial astrocyte markers in induced astrocytes, while electrophysiology and Ca 2+ influx examination further confirmed their functional characteristics. In conclusion, co-silencing of S100A16 and HSP27 without chemical induction leads to PDMCs differentiation into functional astrocytes. Graphical abstract

Distribution of Coomassie Blue Stainable Particles in the Pearl River Estuary, China, Insight Into the Nitrogen Cycling in Estuarine System - Cui-Ci Sun; Wei-Zhong Yue; You-Shao Wang; Wei-Hong He; Yi-Guo Hong; Fu-Lin Sun; Hao Cheng; Mei-Lin Wu; Zhao-Yu Jiang; Fei Jiao; Yu-Tu Wang (Frontiers in Marine Science, 2022)
Distributions of Coomassie Blue stainable particles (CSP), the sources and transports, as well as their implications for nitrogen biogeochemical cycles in the Pearl River estuary (PRE) were investigated during two cruises in August 2016 and January 2017. CSP color concentrations (CSP concentration determined spectrophotometrically) were 73.7–685.3 μg BSA eq L –1 [μg Bovine serum albumin (BSA) equivalent liter –1 ] in August 2016 and 100.6–396.4 μg BSA eq L –1 in January 2017, respectively. CSP concentrations were high in low-salinity waters (<5), and declined from the river to the middle estuary by 80% in the wet season and 55.6% in the dry season, respectively, then increased again in the lower estuary due to high primary production. CSP concentrations were mainly associated with chlorophyll a (Chl a ) concentration except for the turbid mixing zone, suggesting that autochthonous phytoplankton production served as the primary source of CSP in the PRE. The concentrations of nitrogen (N) as CSP in the PRE were comparable to the nitrogen content of particulate hydrolysable amino acids (PHAA). Pictures of CSP taken by microscopy and the correlation between composition of PHAA and the ratio of Chl a /CSP color showed that CSP were relatively degraded due to delivery of old terrestrial protein to river section and extensive microbial degradation during mixing at the upper and middle parts of the estuary, whereas CSP in lower estuary appeared to be more labile due to higher fresh algal production. The contribution of CSP nitrogen (CSP-N) to the particulate nitrogen (PN) pool was 34.98% in summer and 30.8% in winter. The conservative estimate of CSP-N input flux in the Pearl River Delta was about 6 × 10 6 mol N d –1 . These results suggested that CSP was a significant pool of organic nitrogen in the PRE. The study of CSP composition in terms of nitrogen provides new insight into the roles of CSP on nitrogen biogeochemical processes in the turbid and productive estuarine system.

A novel alphahypovirus that infects the fungal plant pathogen Sclerotinia sclerotiorum - Weibo Liang; Zhongbo Lu; Jie Duan; Daohong Jiang; Jiatao Xie; Jiasen Cheng; Yanping Fu; Tao Chen; Bo Li; Xiao Yu; Weidong Chen; Yang Lin (Archives of Virology, 2022)

Nakamurella leprariae sp. nov., isolated from a lichen sample - De-Feng An; Shao-Juan Yang; Long-Qian Jiang; Xin-Yu Wang; Xiao-Yu Huang; Lei Lang; Xue-Mei Chen; Ming-Qun Fan; Gui-Ding Li; Ming-Guo Jiang; Li-Song Wang; Cheng-Lin Jiang; et al. (Archives of Microbiology, 2022)

Does the smart city policy promote the green growth of the urban economy? Evidence from China - Yu Qian; Jun Liu; Zhonghua Cheng; Jeffrey Yi-Lin Forrest (Environmental Science and Pollution Research, 2021)

Evaluating the energy, health efficiency, and productivity in OECD - Ching-Cheng Lu; Yung-ho Chiu; Chih-Yu Yang; Tai-Yu Lin (Environmental Geochemistry and Health, 2021)

Bacterial community variations in the South China Sea driven by different chemical conditions - Fu-lin Sun; You-Shao Wang; Mei-Lin Wu; Cui-Ci Sun; Zhao-Yu Jiang; Hao Cheng; Jiao Fei (Ecotoxicology, 2021)

Complement C3 Aggravates Post-epileptic Neuronal Injury Via Activation of TRPV1 - Guang-Tong Jiang; Lin Shao; Shuo Kong; Meng-Liu Zeng; Jing-Jing Cheng; Tao-Xiang Chen; Song Han; Jun Yin; Wan-Hong Liu; Xiao-Hua He; Yu-Min Liu; Lanzi Gongga; et al. (Neuroscience Bulletin, 2021)

An efficient genetic manipulation protocol for dark septate endophyte Falciphora oryzae - Zhen-Zhu Su; Meng-Di Dai; Jia-Nan Zhu; Yu-Lan Zeng; Xuan-Jun Lu; Xiao-Hong Liu; Fu-Cheng Lin (Biotechnology Letters, 2021)

Development of a dual-labeled, hydrolysis probe-based, real-time quantitative PCR assay for detection of both genotypes of duck circovirus-1 (DuCV-1) and DuCV-2 - Lin Zhang; Wenming Jiang; Fuyou Zhang; Yang Li; Jinping Li; Shaobo Liang; Xiaohui Yu; Cheng Peng; Shuo Liu; Jingjing Wang; Shuhong Sun; Hualei Liu (Virus Genes, 2021)

Use of housefly (Musca domestica L.) larvae to bioconversion food waste for animal nutrition and organic fertilizer - Zhang Cheng; Lin Yu; Hahan Li; Xiaoxun Xu; Zhanbiao Yang (Environmental Science and Pollution Research, 2021)

Acute associations between air pollution on premature rupture of membranes in Hefei, China - Chao Zhang; Sha Li; Gan-lan Guo; Jing-wen Hao; Peng Cheng; Li-lin Xiong; Shu-ting Chen; Ji-yu Cao; Yu-wen Guo; Jia-hu Hao (Environmental Geochemistry and Health, 2021)

Viable and Heat-Killed Probiotic Strains Improve Oral Immunity by Elevating the IgA Concentration in the Oral Mucosa - Wen-Yang Lin; Yi-Wei Kuo; Ching-Wei Chen; Yu-Fen Huang; Chen-Hung Hsu; Jia-Hung Lin; Cheng-Ruei Liu; Jui-Fen Chen; Ko-Chiang Hsia; Hsieh-Hsun Ho (Current Microbiology, 2021)
Oral-nasal mucosal immunity plays a crucial role in protecting the body against bacterial and viral invasion. Safe probiotic products have been used to enhance human immunity and oral health. In this study, we verified the beneficial effects of mixed viable probiotic tablets, consisting of Lactobacillus salivarius subsp. salicinius AP-32, Bifidobacterium animalis subsp. lactis CP-9, and Lactobacillus paracasei ET-66, and heat-killed probiotic tablets, consisting of L. salivarius subsp. salicinius AP-32 and L. paracasei ET-66, on oral immunity among 45 healthy participants. Participants were randomly divided into viable probiotic, heat-killed probiotic, and placebo groups. The administration of treatment lasted for 4 weeks. Saliva samples were collected at Weeks 0, 2, 4, and 6, and Lactobacillus , Bifidobacterium and Streptococcus mutans populations and IgA concentration were measured. IgA concentrations, levels of TGF-beta and IL-10 in PBMCs cells were quantified by ELISA method. Results showed that salivary IgA levels were significantly increased on administration of both the viable (119.30 ± 12.63%, *** P < 0.001) and heat-killed (116.78 ± 12.28%, *** P < 0.001) probiotics for 4 weeks. Among three probiotic strains, AP-32 would effectively increase the levels of TGF-beta and IL-10 in PBMCs. The oral pathogen Streptococcus mutans was significantly reduced on viable probiotic tablet administration (49.60 ± 31.01%, *** P < 0.001). The in vitro antibacterial test confirmed that viable probiotics effectively limited the survival rate of oral pathogens. Thus, this clinical pilot study demonstrated that oral probiotic tablets both in viable form or heat-killed form could exert beneficial effects on oral immunity via IL-10, TGB-beta mediated IgA secretion. The effective dosage of viable probiotic content in the oral tablet was 10 9 CFUs/g and the heat-killed oral tablet was 1 × 10 10 cells/g.

Human Methylmercury Exposure and Potential Impacts in Central Tibet: Food and Traditional Tibetan Medicine - Menghan Cheng; Maodian Liu; Dou Li; Qing Luo; Zhihao Zhang; Liuliang Yuan; Chenghao Yu; Han Xie; Huiming Lin; Qianru Zhang; De Ji; Xuejun Wang (Bulletin of Environmental Contamination and Toxicology, 2021)

Assessment of climate change effects on alpine summit vegetation in the transition of tropical to subtropical humid climate - Chu-Chia Kuo; Yu Su; Ho-Yih Liu; Cheng-Tao Lin (Plant Ecology, 2021)

The major photoprotective role of anthocyanins in leaves of Arabidopsis thaliana under long-term high light treatment: antioxidant or light attenuator? - Xiao-Ting Zheng; Zheng-Chao Yu; Jun-Wei Tang; Min-Ling Cai; Yi-Lin Chen; Cheng-Wei Yang; Wah Soon Chow; Chang-Lian Peng (Photosynthesis Research, 2021)

Performance Comparison of the Deep Learning and the Human Endoscopist for Bleeding Peptic Ulcer Disease - Hsu-Heng Yen; Ping-Yu Wu; Pei-Yuan Su; Chia-Wei Yang; Yang-Yuan Chen; Mei-Fen Chen; Wen-Chen Lin; Cheng-Lun Tsai; Kang-Ping Lin (Journal of Medical and Biological Engineering, 2021)
Purpose Management of peptic ulcer bleeding is clinically challenging. Accurate characterization of the bleeding during endoscopy is key for endoscopic therapy. This study aimed to assess whether a deep learning model can aid in the classification of bleeding peptic ulcer disease. Methods Endoscopic still images of patients ( n = 1694) with peptic ulcer bleeding for the last 5 years were retrieved and reviewed. Overall, 2289 images were collected for deep learning model training, and 449 images were validated for the performance test. Two expert endoscopists classified the images into different classes based on their appearance. Four deep learning models, including Mobile Net V2, VGG16, Inception V4, and ResNet50, were proposed and pre-trained by ImageNet with the established convolutional neural network algorithm. A comparison of the endoscopists and trained deep learning model was performed to evaluate the model’s performance on a dataset of 449 testing images. Results The results first presented the performance comparisons of four deep learning models. The Mobile Net V2 presented the optimal performance of the proposal models. The Mobile Net V2 was chosen for further comparing the performance with the diagnostic results obtained by one senior and one novice endoscopists. The sensitivity and specificity were acceptable for the prediction of “normal” lesions in both 3-class and 4-class classifications. For the 3-class category, the sensitivity and specificity were 94.83% and 92.36%, respectively. For the 4-class category, the sensitivity and specificity were 95.40% and 92.70%, respectively. The interobserver agreement of the testing dataset of the model was moderate to substantial with the senior endoscopist. The accuracy of the determination of endoscopic therapy required and high-risk endoscopic therapy of the deep learning model was higher than that of the novice endoscopist. Conclusions In this study, the deep learning model performed better than inexperienced endoscopists. Further improvement of the model may aid in clinical decision-making during clinical practice, especially for trainee endoscopist.

RSF1 requires CEBP/β and hSNF2H to promote IL-1β-mediated angiogenesis: the clinical and therapeutic relevance of RSF1 overexpression and amplification in myxofibrosarcomas - Chien-Feng Li; Ti-Chen Chan; Cheng-I. Wang; Fu-Min Fang; Po-Chun Lin; Shih-Chen Yu; Hsuan-Ying Huang (Angiogenesis, 2021)

Correction to: Delineation of potential hot spots of aeolian dust using normalized difference water index - Chao-Yuan Lin; Shu-Fen Tsai; Chih-Yun Wang; Cheng-Yu Lin (Theoretical and Applied Climatology, 2021)

Delineation of potential hot spots of aeolian dust using normalized difference water index - Chao-Yuan Lin; Shu-Fen Tsai; Chih-Yun Wang; Cheng-Yu Lin (Theoretical and Applied Climatology, 2021)

Glaciibacter flavus sp. nov., isolated from a lichen sample - De-Feng An; Long-Qian Jiang; Kun Zhang; Gui-Ding Li; Xin-Yu Wang; Ming-Guo Jiang; Lei Lang; Li-Song Wang; Johannes F. Imhoff; Cheng-Lin Jiang; Yi Jiang (Archives of Microbiology, 2021)

In-Situ Seawater Gamma Spectrometry with LaBr3 Detector at a Nuclear Power Plant Outlet - Daowei Dou; Zhi Zeng; Wen Yu; Ming Zeng; Wu Men; Feng Lin; Hao Ma; Jianping Cheng; Junli Li (Journal of Marine Science and Engineering, 2021)
In a nuclear emergency, the application of in situ spectrometers for monitoring environmental radioactivity is significantly important, as information on the type and activity of radionuclides released from the accident can be obtained quickly. However, in emergency environmental radiological monitoring, a balance between energy resolution and detecting efficiency must be considered in selecting an appropriate detector. In this study, in situ gamma spectrometry was conducted with the LaBr3 detector to determine the radioactivity of seawater at the discharging outlet of a coastal nuclear power plant in southeast China. The results show that the LaBr3 scintillator has excellent energy resolution and detection efficiency, making it a promising detector for emergency monitoring.

Detection of Vestibular Schwannoma on Triple-parametric Magnetic Resonance Images Using Convolutional Neural Networks - Tzu-Hsuan Huang; Wei-Kai Lee; Chih-Chun Wu; Cheng-Chia Lee; Chia-Feng Lu; Huai-Che Yang; Chun-Yi Lin; Wen-Yuh Chung; Po-Shan Wang; Yen-Ling Chen; Hsiu-Mei Wu; Wan-You Guo; et al. (Journal of Medical and Biological Engineering, 2021)
Purpose The first step in typical treatment of vestibular schwannoma (VS) is to localize the tumor region, which is time-consuming and subjective because it relies on repeatedly reviewing different parametric magnetic resonance (MR) images. A reliable, automatic VS detection method can streamline the process. Methods A convolutional neural network architecture, namely YOLO-v2 with a residual network as a backbone, was used to detect VS tumors from MR images. To heighten performance, T1-weighted–contrast-enhanced, T2-weighted, and T1-weighted images were combined into triple-channel images for feature learning. The triple-channel images were cropped into three sizes to serve as input images of YOLO-v2. The VS detection effectiveness levels were evaluated for two backbone residual networks that downsampled the inputs by 16 and 32. Results The results demonstrated the VS detection capability of YOLO-v2 with a residual network as a backbone model. The average precision was 0.7953 for a model with 416 × 416-pixel input images and 16 instances of downsampling, when both the thresholds of confidence score and intersection-over-union were set to 0.5. In addition, under an appropriate threshold of confidence score, a high average precision, namely 0.8171, was attained by using a model with 448 × 448-pixel input images and 16 instances of downsampling. Conclusion We demonstrated successful VS tumor detection by using a YOLO-v2 with a residual network as a backbone model on resized triple-parametric MR images. The results indicated the influence of image size, downsampling strategy, and confidence score threshold on VS tumor detection.

Quantitative characterization of horizontal well production performance with multiple indicators: a case study on the Weiyuan shale gas field in the Sichuan Basin, China - Rongze Yu; Wei Guo; Lin Ding; Meizhu Wang; Feng Cheng; Xiaowei Zhang; Shangwen Zhou; Leifu Zhang (Frontiers of Earth Science, 2021)

Experiments on granular flow behavior and deposit characteristics: implications for rock avalanche kinematics - Kun Li; Yu-Feng Wang; Qi-Wen Lin; Qian-Gong Cheng; Yue Wu (Landslides, 2021)

Microbiological profiles and antimicrobial resistance patterns of pediatric bloodstream pathogens in China, 2016–2018 - Yue Qiu; Junwen Yang; Yiping Chen; Jinhong Yang; Qingxiong Zhu; Chunhui Zhu; Shuangjie Li; Jing Liu; Chaomin Wan; Yu Zhu; Minxia Chen; Yi Xu; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Carbon isotope variations of modern soils in the eastern margin of the Tibetan Plateau and their controlling factors - Lin Qi; Yan-song Qiao; Zong-xiu Liu; Sha-sha Peng; Yu Cheng; Yan Wang; Xu-jiao Zhang; Ming-zhong Tian; Shuai-bin Yang; Wen-bin Bai (Journal of Mountain Science, 2021)

The molecular mechanism of a novel derivative of BTO-956 induced apoptosis in human myelomonocytic lymphoma cells - Yu-Lin Li; De-Jun Zhou; Zheng-Guo Cui; Lu Sun; Qian-Wen Feng; Shahbaz Ahmad Zakki; Yusuke Hiraku; Cheng-Ai Wu; Hidekuni Inadera (Apoptosis, 2021)

Simulation of the fragmentation and propagation of jointed rock masses in rockslides: DEM modeling and physical experimental verification - Qi-wen Lin; Qian-Gong Cheng; Yu Xie; Feng-shou Zhang; Kun Li; Yu-feng Wang; Yuan-yuan Zhou (Landslides, 2021)

Delayed association of acute particulate matter 2.5 air pollution exposure with loss of complexity in cardiac rhythm dynamics: insight from detrended fluctuation analysis - Tsung-Ying Tsai; Li-Wei Lo; Shin-Huei Liu; Wen-Han Cheng; Yu-Hui Chou; Wei-Lun Lin; Yenn-Jiang Lin; Shih-Lin Chang; Yu-Feng Hu; Fa-Po Chung; Jo-Nan Liao; Tze-Fan Chao; et al. (Environmental Science and Pollution Research, 2021)

Effects of degradation succession of alpine wetland on soil organic carbon and total nitrogen in the Yellow River source zone, west China - Chun-ying Lin; Xi-lai Li; Jing Zhang; Hua-fang Sun; Juan Zhang; Hui-bang Han; Qi-hua Wang; Cheng-biao Ma; Cheng-yi Li; Yu-xing Zhang; Xue-qian Ma (Journal of Mountain Science, 2021)

Projections from Infralimbic Cortex to Paraventricular Thalamus Mediate Fear Extinction Retrieval - Yan Tao; Cheng-Yun Cai; Jia-Yun Xian; Xiao-Lin Kou; Yu-Hui Lin; Cheng Qin; Hai-Yin Wu; Lei Chang; Chun-Xia Luo; Dong-Ya Zhu (Neuroscience Bulletin, 2021)

Paracoccus lichenicola sp. nov., Isolated from Lichen - Lei Lang; De-Feng An; Long-Qian Jiang; Gui-Ding Li; Li-Song Wang; Xin-Yu Wang; Qin-Yuan Li; Cheng-Lin Jiang; Yi Jiang (Current Microbiology, 2021)

Rapid assessment of landslide risk level based on deep learning - Fei Tan; Jin Yu; Yu-Yong Jiao; Dawei Lin; Jiahe Lv; Yi Cheng (Arabian Journal of Geosciences, 2021)

Improving the observation and prediction capabilities for Arctic marine environment: from the perspective of Arctic Shipping - Hui Wang; Qizhen Sun; Lin Zhang; Xi Liang; Qinghua Yang; Na Liu; Chunhua Li; Qingsheng Liu; Bingrui Li; Qian Feng; Xiao Cheng; Yi Yu (Acta Oceanologica Sinica, 2021)

Concurrent increases in post-pacing action potential duration and contractility predict occurrence of ventricular arrhythmia - Chih-Min Liu; Feng-Zhi Lin; Yao-Chang Chen; Yung-Kuo Lin; Yen-Yu Lu; Cheng-I Wu; Satoshi Higa; Shih-Ann Chen; Yi-Jen Chen (Pflügers Archiv - European Journal of Physiology, 2020)

WDR5a functions in cadmium-inhibited root meristem growth by regulating nitric oxide accumulation in Arabidopsis - Yu Zhang; Yang-Yang Tian; Lin-Feng Wang; Yun-Hui Li; Ting-Ting Li; Wen-Cheng Liu (Planta, 2020)

Optimizing the MIC breakpoints of amoxicillin and tetracycline for antibiotic selection in the rescue therapy of H. pylori with bismuth quadruple regimen - Ming-Tsung Hsieh; Wei-Lun Chang; Chung-Tai Wu; Hsiao-Bai Yang; Hsin-Yu Kuo; Meng-Ying Lin; Hsiu-Chi Cheng; Yu-Chin Tsai; Bor-Shyang Sheu (European Journal of Clinical Pharmacology, 2020)

Assimilation of exogenous cyanide cross talk in Oryza sativa L. to the key nodes in nitrogen metabolism - Cheng-Zhi Li; Li Yang; Yu-Juan Lin; Hua Zhang; Saeed Rad; Xiao-Zhang Yu (Ecotoxicology, 2020)

Characterization of a Protease Hyper-Productive Mutant of Bacillus pumilus by Comparative Genomic and Transcriptomic Analysis - Yong-Cheng Liu; Lin-Li Han; Tian-Yu Chen; Yan-Bing Lu; Hong Feng (Current Microbiology, 2020)

Cerebral Organoids Repair Ischemic Stroke Brain Injury - Shu-Na Wang; Zhi Wang; Tian-Ying Xu; Ming-He Cheng; Wen-Lin Li; Chao-Yu Miao (Translational Stroke Research, 2020)
Stroke is the second leading cause of death and main cause of disability worldwide, but with few effective therapies. Although stem cell-based therapy has been proposed as an exciting regenerative medicine strategy for brain injury, there are limitations. The developed cerebral organoids (COs) represent a promising transplantation source for stroke that remains to be answered. Here, we transplanted COs at 55 days and explored the feasibility in the rat middle cerebral artery occlusion (MCAO) model of stroke. COs transplantation at 6 h or even 24 h after MCAO significantly reduces brain infarct volume and improves neurological motor function. Transplanted COs show the potential of multilineage differentiation to mimic in vivo cortical development, support motor cortex region-specific reconstruction, form neurotransmitter-related neurons, and achieve synaptic connection with host brain via in situ differentiation and cell replacement in stroke. Cells from transplanted COs show extensive migration into different brain regions along corpus callosum. The mechanisms underlying COs transplantation therapy are also associated with enhanced neurogenesis, synaptic reconstruction, axonal regeneration and angiogenesis, and decreased neural apoptosis with more survival neurons after stroke. Moreover, COs transplantation promotes predominantly exogenous neurogenesis in the transplantation periphery of ipsilateral cortex and predominantly endogenous neurogenesis in the hippocampus and subventricular zone. Together, we demonstrate the efficacy and underlying mechanisms of COs transplantation in stroke. This preliminary but promising study provides first-hand preclinical evidence for COs transplantation as a potential and effective intervention for stroke treatment.

Matriptase and prostasin proteolytic activities are differentially regulated in normal and wounded skin - Shun-Cheng Chang; Chien-Ping Chiang; Chih-Hsin Lai; Po-Wen A. Du; Yu-Sin Hung; Yu-Hsuan Chen; Hui-Yu Yang; Hao-Yu Fang; Shiao-Pieng Lee; Hung-Jen Tang; Jehng-Kang Wang; Michael D. Johnson; et al. (Human Cell, 2020)

Modification-bioremediation of copper, lead, and cadmium-contaminated soil by combined ryegrass (Lolium multiflorum Lam.) and Pseudomonas aeruginosa treatment - Guang-yu Shi; Ying-jia Yan; Zhi-qiang Yu; Lu Zhang; Yuan-yuan Cheng; Wei-lin Shi (Environmental Science and Pollution Research, 2020)

Energy consumption, environmental pollution, and technological innovation efficiency: taking industrial enterprises in China as empirical analysis object - Cheng-lin Miao; Xiao-na Meng; Meng-meng Duan; Xin-yu Wu (Environmental Science and Pollution Research, 2020)

Distribution patterns and source identification for heavy metals in Mirs Bay of Hong Kong in China - Mei-Lin Wu; Hao Cheng; Hui Zhao; Fu-Lin Sun; Yu-Tu Wang; Jian-Ping Yin; Jiao Fei; Cui-Ci Sun; You-Shao Wang (Ecotoxicology, 2020)

Phytoplankton community, structure and succession delineated by partial least square regression in Daya Bay, South China Sea - Mei-Lin Wu; Yu-Tu Wang; Hao Cheng; Fu-lin Sun; Jiao Fei; Cui-Ci Sun; Jian-Ping Yin; Hui Zhao; You-Shao Wang (Ecotoxicology, 2020)

Nakamurella albus sp. nov.: A Novel Actinobacterium Isolated from a Lichen Sample - Long-Qian Jiang; De-Feng An; Kun Zhang; Gui-Ding Li; Xin-Yu Wang; Lei Lang; Ming-Guo Jiang; Li-Song Wang; Cheng-Lin Jiang; Yi Jiang (Current Microbiology, 2020)

Reconnaissance and learning after the February 6, 2018, earthquake in Hualien, Taiwan - Jui-Liang Lin; Chun-Hsiang Kuo; Yu-Wen Chang; Shu-Hsien Chao; Yi-An Li; Wen-Cheng Shen; Chung-Han Yu; Cho-Yen Yang; Fan-Ru Lin; Hsiao-Hui Hung; Chun-Chung Chen; Chin-Kuo Su; et al. (Bulletin of Earthquake Engineering, 2020)

Hispidulin Inhibits Neuroinflammation in Lipopolysaccharide-Activated BV2 Microglia and Attenuates the Activation of Akt, NF-κB, and STAT3 Pathway - Chung-I Yu; Cheng-I Cheng; Ya-Fei Kang; Po-Chih Chang; In-Pin Lin; Yu-His Kuo; An-Jie Jhou; Mei-Ying Lin; Chung-Yi Chen; Chien-Hsing Lee (Neurotoxicity Research, 2020)

Reversal of Social Recognition Deficit in Adult Mice with MECP2 Duplication via Normalization of MeCP2 in the Medial Prefrontal Cortex - Bin Yu; Bo Yuan; Jian-Kun Dai; Tian-lin Cheng; Sheng-Nan Xia; Ling-Jie He; Yi-Ting Yuan; Yue-Fang Zhang; Hua-Tai Xu; Fu-Qiang Xu; Zhi-Feng Liang; Zi-Long Qiu (Neuroscience Bulletin, 2020)

Short-term associations between ambient fine particulate matter pollution and hospital visits for chronic obstructive pulmonary disease in Yinzhou District, China - Cheng-yi Lin; Die Li; Jie-ming Lu; Zhe-bin Yu; Yao Zhu; Peng Shen; Meng-ling Tang; Ming-juan Jin; Hong-bo Lin; Li-ming Shui; Kun Chen; Jian-bing Wang (Environmental Science and Pollution Research, 2020)

First report of Fusarium oxysporum f. sp. canariensis causing Fusarium wilt on Canary Island date palm (Phoenix canariensis Hort. Ex Chabaud) in China - Cheng Zhong Lan; Yu Li Dai; Lin Gan; Jin Ai Yao; Xiu Juan Yang (Journal of Plant Pathology, 2020)

Multiple genetic factors affecting the pharmacokinetic and pharmacodynamic processes of tacrolimus in Chinese myasthenia gravis patients - Huan-Yu Meng; Xi Li; Wan-Lin Jin; Cheng-Kai Yan; Xiao-Hua Dong; Qiu Xu; Yu-Yao Peng; Zhi-Bin Li; Yi Li; Zhao-Hui Luo; Li-Qun Xu; Huan Yang (European Journal of Clinical Pharmacology, 2020)

The evaluation of BTEX and carbonyls emissions from recycled building materials - Yu-Hsiang Cheng; Chi-Chi Lin; Yun-Tai Lee; Yu-Chun Lin (Environmental Monitoring and Assessment, 2020)

Mechanisms behind soil N dynamics following cover restoration in degraded land in subtropical China - Xiangzhou Zheng; Cheng Lin; Baoling Guo; Juhua Yu; Hong Ding; Shaoyun Peng; Jinbo Zhang; Eric Ireland; Deli Chen; Christoph Müller; Yushu Zhang (Journal of Soils and Sediments, 2020)

Impacts of elevated temperature and pCO2 on the brooded larvae of Pocillopora damicornis from Luhuitou Reef, China: evidence for local acclimatization - Lei Jiang; Ming-Lan Guo; Fang Zhang; Yu-Yang Zhang; Guo-Wei Zhou; Xin-Ming Lei; Xiang-Cheng Yuan; You-Fang Sun; Tao Yuan; Lin Cai; Jian-Sheng Lian; Sheng Liu; et al. (Coral Reefs, 2020)

MicroRNA-mediated responses to colchicine treatment in barley - Fang-Yao Sun; Lin Liu; Yi Yu; Xin-Ming Ruan; Cheng-Yu Wang; Qun-Wen Hu; De-Xiang Wu; Genlou Sun (Planta, 2020)

Therapeutic Efficacy of Subcutaneous and Intraperitoneal Injections of a Single Dose of Human Umbilical Mesenchymal Stem Cells in Acute and Chronic Colitis in a Mouse Model - Yu-Lung Chang; Huei-Yu Lo; Shun-Ping Cheng; Kuo-Ting Chang; Xiu-Fang Lin; Sheng-Ping Lee; Jason Ma; Ming-Ling Kuo; Ming-Fa Hsieh; Chin-Kan Chan (Journal of Medical and Biological Engineering, 2020)

Pulse Oximetry Monitor Feasible for Early Screening of Obstructive Sleep Apnea (OSA) - Huei-Chen Lin; Chien-Ling Su; Jun-Hui Ong; kun-ling Tsai; Yu-Wen Chen; Cheng-Yu Lin; Ling-Ling Chiang; Ching-Hsia Hung (Journal of Medical and Biological Engineering, 2020)

Aureimonas leprariae sp. nov., Isolated from a Lepraria sp. Lichen - Kun Zhang; Long-Qian Jiang; Li-Song Wang; De-Feng An; Lei Lang; Gui-Ding Li; Xin-Yu Wang; Song-Biao Shi; Qin-Yuan Li; Cheng-Lin Jiang; Yi Jiang (Current Microbiology, 2020)

Rubellimicrobium rubrum sp. nov., a novel bright reddish bacterium isolated from a lichen sample - Long-Qian Jiang; Kun Zhang; Gui-Ding Li; Xin-Yu Wang; Song-Biao Shi; Qin-Yuan Li; De-Feng An; Lei Lang; Li-Song Wang; Cheng-Lin Jiang; Yi Jiang (Antonie van Leeuwenhoek, 2019)

Application of Cas12a and nCas9-activation-induced cytidine deaminase for genome editing and as a non-sexual strategy to generate homozygous/multiplex edited plants in the allotetraploid genome of tobacco - Chen-Tran Hsu; Yu-Jung Cheng; Yu-Hsua Yuan; Wei-Fon Hung; Qiao-Wei Cheng; Fu-Hui Wu; Lan-Ying Lee; Stanton B. Gelvin; Choun-Sea Lin (Plant Molecular Biology, 2019)

Aflatoxin B1 enhances pyroptosis of hepatocytes and activation of Kupffer cells to promote liver inflammatory injury via dephosphorylation of cyclooxygenase-2: an in vitro, ex vivo and in vivo study - Li-Yin Zhang; Deng-Lin Zhan; Yuan-Yuan Chen; Wei-Hua Wang; Cheng-Yong He; Yi Lin; Yu-Chun Lin; Zhong-Ning Lin (Archives of Toxicology, 2019)

MicroRNA-365 Knockdown Prevents Ischemic Neuronal Injury by Activating Oxidation Resistance 1-Mediated Antioxidant Signals - Jia-Lin Mo; Zhi-Guang Pan; Xiao Chen; Yu Lei; Ling-Ling Lv; Cheng Qian; Feng-Yan Sun (Neuroscience Bulletin, 2019)

Evaluation of Coherence Between ECG and PPG Derived Parameters on Heart Rate Variability and Respiration in Healthy Volunteers With/Without Controlled Breathing - Hao-Yu Jan; Mei-Fen Chen; Tieh-Cheng Fu; Wen-Chen Lin; Cheng-Lun Tsai; Kang-Ping Lin (Journal of Medical and Biological Engineering, 2019)