Two genetic divergence centers revealed by chloroplastic DNA variation in populations of Cinnamomum kanehirae Hay - Dai-Chang Kuo; Chia-Chia Lin; Kuo-Chieh Ho; Yu-Pin Cheng; Shih-Ying Hwang; Tsan-Piao Lin (Conservation Genetics, 2010)

Chloroplast transformation of rapeseed (Brassica napus) by particle bombardment of cotyledons - Lin Cheng; He-Ping Li; Bo Qu; Tao Huang; Jin-Xing Tu; Ting-Dong Fu; Yu-Cai Liao (Plant Cell Reports, 2010)

An integrated approach for identification of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) pollutant sources based on human blood contents - Yu-Cheng Chen; Perng-Jy Tsai; Lin-Chi Wang; Minliang Shih; Wen-Jhy Lee (Environmental Science and Pollution Research, 2010)

Meat and egg consumption and risk of breast cancer among Chinese women - Cai-Xia Zhang; Suzanne C. Ho; Yu-Ming Chen; Fang-Yu Lin; Jian-Hua Fu; Shou-Zhen Cheng (Cancer Causes & Control, 2009)

Function of Drosophila mob2 in photoreceptor morphogenesis - Ling-Yu Liu; Cheng-Han Lin; Seng-Sheen Fan (Cell and Tissue Research, 2009)

Empirical Models to Predict Parsimoniously the Mass and Number Concentrations of Ultrafine Particulate in Ambient Atmosphere - Chia-Pin Chio; Man-Ting Cheng; Yu-Chi Lin; Chung-Min Liao (Bulletin of Environmental Contamination and Toxicology, 2009)

Fabrication of a Novel Core-Shell Gene Delivery System Based on a Brush-Like Polycation of α, β–Poly (L-Aspartate-Graft-PEI) - Jia-Hui Yu; Ji-Shan Quan; Jung-Taek Kwon; Cheng-Xiong Xu; Bo Sun; Hu-Lin Jiang; Jae-Woon Nah; Eun-Mi Kim; Hwan-Jeong Jeong; Myung-Haing Cho; Chong-Su Cho (Pharmaceutical Research, 2009)

Memory deficits and neurochemical changes induced by C-reactive protein in rats: implication in Alzheimer’s disease - Huan-Bing Lin; Xue-Mei Yang; Tie-Jun Li; Yu-Fang Cheng; Han-Ting Zhang; Jiang-Ping Xu (Psychopharmacology, 2009)

A ThCAP gene from Tamarix hispida confers cold tolerance in transgenic Populus (P. davidiana × P. bolleana) - Xiao-Hong Guo; Jing Jiang; Shi-Jie Lin; Bai-Chen Wang; Yu-Cheng Wang; Gui-Feng Liu; Chuan-Ping Yang (Biotechnology Letters, 2009)

A vitronectin M381T polymorphism increases risk of hemangioblastoma in patients with VHL gene defect - Jing-Shan Huang; Chih-Ming Lin; Yu-Che Cheng; Kun-Long Hung; Chih-Cheng Chien; Shao-Kuan Chen; Chih-Ju Chang; Chan-Wei Chen; Chi-Jung Huang (Journal of Molecular Medicine, 2009)

Recombinant ORF66 and ORFK12 antigens for the detection of human herpesvirus 8 antibodies in HIV-positive and -negative patients - Tsuey-Ching Yang; Chun-Pin Chang; Yu-Ching Lan; Chao-Li Liu; Mu-Chin Shih; Fang-Yang Wu; Cheng-Wen Lin (Biotechnology Letters, 2009)

Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci - Shu-Feng Lei; Tie-Lin Yang; Li-Jun Tan; Xiang-Ding Chen; Yan Guo; Yan-Fang Guo; Liang Zhang; Xiao-Gang Liu; Han Yan; Feng Pan; Zhi-Xin Zhang; Yu-Mei Peng; et al. (Human Genetics, 2009)

Effect of calmidazolium on [Ca2+]i and viability in human hepatoma cells - Wei-Chuan Liao; Chorng-Chih Huang; He-Hsiung Cheng; Jue-Long Wang; Ko-Long Lin; Jin-Shiung Cheng; Kuo-Liang Chai; Pei-Te Hsu; Jeng-Yu Tsai; Yi-Chien Fang; Yih-Chau Lu; Hong-Tai Chang; et al. (Archives of Toxicology, 2009)

Isolation and characterization of microsatellite loci in the commercially important mudshrimp Austinogebia edulis (Upogebiidae) using PCR-based isolation of microsatellite arrays (PIMA) - Tzen-Yuh Chiang; Hung-Du Lin; Tin-Yam Chan; Cheng-Yu Hung; Feng-Jiau Lin (Conservation Genetics, 2008)

Time to rehospitalization in patients with bipolar I disorder on lithium or valproate with adjunctive antipsychotics - Ching-Hua Lin; Ching-Wen Huang; Cheng-Chung Chen; Yu-Fen Hsu; Wen-Ho Chang; Hsien-Yuan Lane (Psychopharmacology, 2008)

Fluorescent co-localization of PTS1 and PTS2 and its application in analysis of the gene function and the peroxisomal dynamic in Magnaporthe oryzae - Jiao-yu Wang; Xiao-yan Wu; Zhen Zhang; Xin-fa Du; Rong-yao Chai; Xiao-hong Liu; Xue-qin Mao; Hai-ping Qiu; Yan-li Wang; Fu-cheng Lin; Guo-chang Sun (Journal of Zhejiang University-SCIENCE B, 2008)

Gene expression variation increase in trisomy 21 tissues - Ching Yu Chou; Li Yu Liu; Chien Yu Chen; Cheng Hsien Tsai; Hsiao Lin Hwa; Li Yun Chang; Yi Shing Lin; Fon Jou Hsieh (Mammalian Genome, 2008)

Complete sequence analysis reveals two distinct poleroviruses infecting cucurbits in China - Hai-ying Xiang; Qiao-xia Shang; Cheng-gui Han; Da-wei Li; Jia-lin Yu (Archives of Virology, 2008)

Spatiotemporal distribution of arsineic species of oysters (Crassostrea gigas) in the coastal area of southwestern Taiwan - Chen-Wuing Liu; Yung-Kay Huang; Yu-Mei Hsueh; Kao-Hung Lin; Cheng-Shin Jang; Lan-Ping Huang (Environmental Monitoring and Assessment, 2008)

Characteristics of Atmospheric Aerosol and Acidic Gases from Urban and Forest Sites in Central Taiwan - Man-Ting Cheng; Chuen-Liang Horng; Yu-Chi Lin (Bulletin of Environmental Contamination and Toxicology, 2007)

Complete sequence of a subgroup 3.4 strain of classical swine fever virus from Taiwan - Yu-Ju Lin; Maw-Sheng Chien; Ming-Chung Deng; Chin-Cheng Huang (Virus Genes, 2007)

A rice phenomics study—phenotype scoring and seed propagation of a T-DNA insertion-induced rice mutant population - Chyr-Guan Chern; Ming-Jen Fan; Su-May Yu; Ai-Ling Hour; Po-Chang Lu; Yao-Cheng Lin; Fu-Jin Wei; Sheng-Chung Huang; Shu Chen; Ming-Hsing Lai; Ching-Shan Tseng; Hsing-Mu Yen; et al. (Plant Molecular Biology, 2007)

Streptomyces serianimatus sp. nov., isolated from a rhizophere soil - Yong-Xia Wang; Xiao-Yang Zhi; Hua-Hong Chen; Yu-Qin Zhang; Shu Kun Tang; Cheng-Lin Jiang; Li-Hua Xu; Wen-Jun Li (Antonie van Leeuwenhoek, 2007)

Effects of magnesium sulfate on dynamic changes of brain glucose and its metabolites during a short-term forced swimming in gerbils - Shiu-Min Cheng; Dar-Yu Yang; Chien-Pin Lee; Hung-Chuan Pan; Mao-Tsun Lin; Ssu-Hua Chen; Fu-Chou Cheng (European Journal of Applied Physiology, 2007)

A rice gene activation/knockout mutant resource for high throughput functional genomics - Yue-Ie Hsing; Chyr-Guan Chern; Ming-Jen Fan; Po-Chang Lu; Ku-Ting Chen; Shuen-Fang Lo; Peng-Kai Sun; Shin-Lon Ho; Kuo-Wei Lee; Yi-Chieh Wang; Wen-Lii Huang; Swee-Suak Ko; et al. (Plant Molecular Biology, 2007)

Effect of Epstein–Barr virus infection on global gene expression in nasopharyngeal carcinoma - Yuan-Chii Gladys Lee; Yu-Chyi Hwang; Kuang-Chi Chen; Yong-Shiang Lin; Dah-Yeou Huang; Tao-Wei Huang; Cheng-Yan Kao; Han-Chung Wu; Chin-Tarng Lin; Chi-Ying F. Huang (Functional & Integrative Genomics, 2006)

Over-expressed estrogen receptor-α up-regulates hTNF-α gene expression and down-regulates β-catenin signaling activity to induce the apoptosis and inhibit proliferation of LoVo colon cancer cells - Hsi-Hsien Hsu; Sue-Fei Cheng; Li-Mien Chen; Jer-Yu Liu; Chun-Hsien Chu; Yi-Jiun Weng; Zih-Ying Li; Chung-Sheng Lin; Shin-Da Lee; Wei-Wen Kuo; Chih-Yang Huang (Molecular and Cellular Biochemistry, 2006)

Contrasting phylogeographical patterns of two closely related species, Machilus thunbergii and Machilus kusanoi (Lauraceae), in Taiwan - Su‐Hwa Wu; Ching‐Yuan Hwang; Tsan‐Piao Lin; Jeng‐Der Chung; Yu‐Pin Cheng; Shih‐Ying Hwang (Journal of Biogeography, 2006)
Aim The purpose of this paper was to study the patterns of genetic variation, demographic history, haplotype relationships and potential location of diversity centres of two closely related species, Machilus thunbergii and Machilus kusanoi . Location The phylogeography of M. thunbergii and M. kusanoi was examined by sampling 110 and 106 individuals from 25 and 16 sampling sites, respectively, across their distributional range in Taiwan. Machilus thunbergii is distributed on the Asian mainland, South Korea, southern Japan, the Ryukyus, Taiwan and the Philippines, whereas M. kusanoi is endemic to Taiwan. These two species are closely related, and both are widely distributed in Taiwan but occupy different altitudinal zones and habitats. Methods The range‐wide variation of M. thunbergii and M. kusanoi in Taiwan was studied using chloroplast DNA (cpDNA) variations. A haplotype network was constructed with the computer program tcs . Nested clade analysis was conducted with the computer program ceodis , and various parameters of genetic diversity were calculated and neutrality tested by the computer program D na SP. Population differentiation was estimated using the programs arlequin and hapstep . The contribution of the populations to gene diversity and to allelic richness was calculated using the software contrib . The level of divergence for each population from the remaining populations was calculated as the mean value of pairwise F ST for each population against the rest of the populations. Results Extremely low levels of genetic differentiation were found for both species. This result suggested that these two species probably survived in multiple relict refugia with different population sizes throughout the island during low‐temperature periods of the Pleistocene. In addition, nested clade analysis (NCA) of cpDNA haplotypes indicated that restricted gene flow with isolation‐by‐distance characterized the recolonization after the Pleistocene by Tashueshan and Shiouhluan populations of M. thunbergii in the north‐central area west of the Central Mountain Range (CMR). In contrast, NCA analysis indicated that a major diversity centre on the southern tip of the island (Kending population) and contiguous range expansion characterized the recolonization by M. kusanoi of northern areas along the east side of the CMR. The major diversity centres found for the two species examined were further supported by the results of the mean F ST for individual populations in comparison with other populations, and of the contribution of the divergence component to the total diversity. Main conclusions This research supports the multiple relict refugia hypothesis for both species investigated. Populations of M. thunbergii at Shiouhluan and Tashueshan in the north‐central area west of the CMR represent a diversity centre currently expanding its size. A diversity centre at the southern‐edge population of M. kusanoi , and a contiguous range expansion from Kending, were found. These results indicate that the M. thunbergii populations at Tashueshan and Shiouhluan and the M. kusanoi population at Kending, and even Soukar, are evolutionarily significant units for conservation programmes.

Microsatellite Loci from Lanyu Scops Owl (Otus elegans botelensis) and their Cross-Species Application in Four Species of Strigidae - Yu-Cheng Hsu; Shou-Hsien Li; Yao-Sung Lin; Lucia Liu Severinghaus (Conservation Genetics, 2006)

Promoter trapping in Magnaporthe grisea - Xiao-hong Liu; Jian-ping Lu; Jiao-yu Wang; Hang Min; Fu-cheng Lin (Journal of Zhejiang University-SCIENCE B, 2006)

Inhibitory effect of trilinolein on endothelin-1-induced c-fos gene expression in cultured neonatal rat cardiomyocytes - Hung-Yu Yang; Ju-Chi Liu; Yen-Ling Chen; Cheng-Hsien Chen; Heng Lin; Jia-Wei Lin; Wen-Ta Chiu; Jin-Jer Chen; Tzu-Hurng Cheng (Naunyn-Schmiedeberg's Archives of Pharmacology, 2005)

Potential refugia in Taiwan revealed by the phylogeographical study of Castanopsis carlesii Hayata (Fagaceae) - YU‐PIN CHENG; SHIH‐YING HWANG; TSAN‐PIAO LIN (Molecular Ecology, 2005)
In this study, we examined spatial patterns of chloroplast DNA (cpDNA) variation in a total of 30 populations of Castanopsis carlesii Hayata (Fagaceae), a subtropical and temperate tree species, including 201 individuals sampled throughout Taiwan. By sequencing two cpDNA fragments using universal primers (the trn L intron and the trn V‐ trn M intergenic spacer), we found a total of 1663 bp and 21 polymorphic sites. These gave rise to a total of 28 cpDNA haplotypes. The level of differentiation among the populations studied was relatively high ( G ST = 0.723). Two ancestral haplotypes are widely distributed. The Central Mountain Ridge (CMR) of Taiwan represents an insurmountable barrier to the east–west gene flow of C. carlesii . Among the populations studied, three separated populations, at Lienhuachih, Fushan and Lichia, have high nucleotide diversity. Estimates of N ST – G ST for populations on both sides of the CMR indicate that no phylogeographical structure exists. According to the genealogical tree, number of rare haplotype and population genetic divergence, this study suggests that two potential refugia existed during the last glaciation: the first refugium was located in a region to the north of Hsuehshan Range (HR) and west of the CMR; the second refugium was located in south, especially southeastern Taiwan. In fact, the second refugium happens to be the same as that reported for Quercus glauca . A ‘star‐like’ genealogy is characteristic when all haplotypes rapidly coalesce and is a general outcome of population expansion. The neutrality test and mismatch distribution also suggest demographic expansion recovering from a bottleneck.

Nucleotide Sequences and Functions of the Epstein-Barr Virus Latent Membrane Protein 1 Genes Isolated from Salivary Gland Lymphoepithelial Carcinomas - Kai Yu Jen; Masaya Higuchi; Jun Cheng; Jiang Li; Lan Yan Wu; Ying Fang Li; Han Liang Lin; Zhilong Chen; Vladimir Gurtsevitch; Masahiro Fujii; Takashi Saku (Virus Genes, 2005)

Representative appressorium stage cDNA library of Magnaporthe grisea - Jian-ping Lu; Tong-bao Liu; Xiao-yun Yu; Fu-cheng Lin (Journal of Zhejiang University-SCIENCE B, 2005)

Transgenic tomato plants expressing the Arabidopsis NPR1 gene display enhanced resistance to a spectrum of fungal and bacterial diseases - Wan-Chi Lin; Ching-Fang Lu; Jia-Wei Wu; Ming-Lung Cheng; Yu-Mei Lin; Ning-Sun Yang; Lowell Black; Sylvia K. Green; Jaw-Fen Wang; Chiu-Ping Cheng (Transgenic Research, 2004)

Antitermitic and Antifungal Activities of Essential Oil of Calocedrus formosana Leaf and Its Composition - Sen-Sung Cheng; Chi-Lin Wu; Hui-Ting Chang; Yu-Ting Kao; Shang-Tzen Chang (Journal of Chemical Ecology, 2004)

Spatial and temporal dynamics of soil organic carbon in reserved desertification area - Shu-lan Cheng; Hua Ouyang; Hai-shan Niu; Lin Wang; Feng Zhang; Jun-qin Gao; Yu-qiang Tian (Chinese Geographical Science, 2004)

A thermostable leucine aminopeptidase from Bacillus kaustophilus CCRC 11223 - Long-Liu Lin; Wen-Hwei Hsu; Cheng-Pu Wu; Meng-Chun Chi; Wei-Mou Chou; Hui-Yu Hu (Extremophiles, 2004)

The mechanism of honokiol-induced and magnolol-induced inhibition on muscle contraction and Ca 2+ mobilization in rat uterus - Yu-Cheng Lu; Hwei-Hsien Chen; Chien-Hsin Ko; Yi-Ruu Lin; Ming-Huan Chan (Naunyn-Schmiedeberg's Archives of Pharmacology, 2003)

Development of the Fragment Constant Method for Estimating the Partition Coefficients of Nonionic Organic Mixtures - Z. Lin, H. Yu, S. Gao, J. Cheng, L. Wa (Archives of Environmental Contamination and Toxicology, 2001)

Cloning and expression of the α-amylase gene and oxytetracycline production in Streptomyces rimosus - Chun-Wen Cheng; Jin-Seng Lin; Yu-Tien Liu; Shang-Shyng Yang (World Journal of Microbiology and Biotechnology, 2000)

Contributory presentations/posters - N. Manoj; V. R. Srinivas; A. Surolia; M. Vijayan; K. Suguna; R. Ravishankar; K. Suguna; A. Surolia; M. Vijayan; R. Schwarzenbacher; K. Zeth; Diederichs; et al. (Journal of Biosciences, 1999)