The Influence of the Rotary Speed of a Microwave Applicator on Hard-Rock Fracturing Effect - Xia-ting Feng; Shi-ping Li; Cheng-xiang Yang; Feng Lin; Tian-yang Tong; Xiang-xin Su; Jiu-yu Zhang (Rock Mechanics and Rock Engineering, 2022)

Synthesis and biological evaluation of new thiazolyl-urea derivatives as potential dual C-RAF/FLT3 inhibitors - Zhi-Hua Zhang; Bi-Fan Zeng; Zhe-Xue Song; Ying-Yu Yang; Kai-yun Zhang; Xue Du; Lin-lin Zhang; Dong Cai (Medicinal Chemistry Research, 2022)

Microarray analysis of mRNA expression profiles in liver of ob/ob mice with real-time atmospheric PM2.5 exposure - Lisen Lin; Li Tian; Tianyu Li; Mengqi Sun; Junchao Duan; Yang Yu; Zhiwei Sun (Environmental Science and Pollution Research, 2022)

Surfactin isoforms isolated from a mushroom derived Bacillus halotolerans DMG-7-2 - Guo-Feng Zhou; Lin Yang; Shu-Hua Zhang; Yi Wang; Yu Yang; Rui Xu; Xue Zhao; Dan Nie; Junjie Shan; Cheng-Bin Cui; Chang-Wei Li (Natural Product Research, 2022)

Effects of tillage and cropping sequences on crop production and environmental benefits in the North China Plain - Wen-Xuan Liu; Wen-Sheng Liu; Mu-Yu Yang; Yu-Xin Wei; Zhe Chen; Ahmad Latif Virk; Rattan Lal; Xin Zhao; Hai-Lin Zhang (Environmental Science and Pollution Research, 2022)

Can artificial intelligence improve green economic growth? Evidence from China - Yu Qian; Jun Liu; Lifan Shi; Jeffrey Yi-Lin Forrest; Zhidan Yang (Environmental Science and Pollution Research, 2022)

Construction of a core germplasm bank of upland cotton (Gossypium hirsutum L.) based on phenotype, genotype and favorable alleles - Peng Han; Xiaomin Tian; Ying Wang; Cong Huang; Yizan Ma; Xiaofeng Zhou; Yu Yu; Dawei Zhang; Haijiang Xu; Yang Cao; Bo Zhu; Zhenxiu Feng; et al. (Genetic Resources and Crop Evolution, 2022)

Clinical profiles and antimicrobial resistance patterns of invasive Salmonella infections in children in China - Wen Song; Qingwen Shan; Yue Qiu; Xianyao Lin; Chunhui Zhu; Zhiqiang Zhuo; Caihong Wang; Jianning Tong; Rui Li; Chaomin Wan; Yu Zhu; Minxia Chen; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2022)
Invasive Salmonella infections result in a significant burden of disease including morbidity, mortality, and financial cost in many countries. Besides typhoid fever, the clinical impact of non-typhoid Salmonella infections is increasingly recognized with the improvement of laboratory detection capacity and techniques. A retrospective multicenter study was conducted to analyze the clinical profiles and antimicrobial resistance patterns of invasive Salmonella infections in hospitalized children in China during 2016–2018. A total of 130 children with invasive Salmonella infections were included with the median age of 12 months (range: 1–144 months). Seventy-nine percent of cases occurred between May and October. Pneumonia was the most common comorbidity in 33 (25.4%) patients. Meningitis and septic arthritis caused by nontyphoidal Salmonella (NTS) infections occurred in 12 (9.2%) patients and 5 (3.8%) patients. Patients < 12 months (OR: 16.04) and with septic shock (OR: 23.4), vomit (OR: 13.33), convulsion (OR: 15.86), C-reactive protein (CRP) ≥ 40 g/L (OR: 5.56), and a higher level of procalcitonin (PCT) (OR: 1.05) on admission were statistically associated to an increased risk of developing meningitis. Compared to 114 patients with NTS infections , 16 patients with typhoid fever presented with higher levels of CRP and PCT ( P < 0.05). The rates of resistance to ampicillin, sulfamethoxazole/trimethoprim, ciprofloxacin, and ceftriaxone among Salmonella Typhi and NTS isolates were 50% vs 57.3%, 9.1% vs 24.8%, 0% vs 11.2%, and 0% vs 9.9%, respectively. NTS has been the major cause of invasive Salmonella infections in Chinese children and can result in severe diseases. Antimicrobial resistance among NTS was more common.

Role of ocean dynamics in equatorial Pacific decadal variability - Yu Zhang; Shi-Yun Yu; Shang-Ping Xie; Dillon J. Amaya; Qihua Peng; Yu Kosaka; Xiaopei Lin; Jun-Chao Yang; Sarah M. Larson; Arthur J. Miller; Lei Fan (Climate Dynamics, 2022)

Streptococcus humanilactis sp.nov., isolated from healthy nursing mother's breast milk - Xiaoqing Guo; Fei Han; Lin Cong; Yu Li; Yue Wu; Chen Liu; Jingfang Yang; Risu Na; Wenjun Liu (Archives of Microbiology, 2022)

Three-dimensional characteristics of mesoscale eddies simulated by a regional model in the northwestern Pacific Ocean during 2000–2008 - Guijing Yang; Xiayan Lin; Guoqing Han; Yu Liu; Gengxin Chen; Jianhui Wang (Acta Oceanologica Sinica, 2022)

Gregarious larval settlement mediates the responses of new recruits of the reef coral Acropora austera to ocean warming and acidification - Lei Jiang; Yu-Yang Zhang; Cheng-Yue Liu; Lin-Tao Huang; Hao-Ya Tong; Guo-Wei Zhou; Ming-Lan Guo; Tao Yuan; Hui Huang (Frontiers in Marine Science, 2022)
Gregarious larval settlement represents an important window for chimera formation in reef corals, yet it remains largely unknown how aggregated settlement and early chimerism could modify the performance and responses of coral recruits under elevated temperature and p CO 2 . In this study, single and aggregated recruits of the broadcast spawning coral Acropora austera were exposed to contrasts of two temperatures (28 versus 30.5°C) and p CO 2 levels (~500 versus 1000 μatm) for two weeks, and algal symbiont infection success, survivorship and growth were assessed. Results showed that symbiont infection success was mainly affected by temperature and recruit type, with reduced symbiont infection at increased temperature and consistently higher infection success in chimeric recruits compared to single recruits. Furthermore, although chimeric recruits with larger areal size had significantly higher survivorship in all treatments, the polyp-specific growth rates were considerably lower in chimeric entities than individual recruits. More importantly, the recruit type significantly influenced the responses of recruit polyp-specific growth rates to elevated temperature, with chimeras exhibiting lowered skeletal lateral growth under elevated temperature. These results demonstrate the benefits and costs associated with gregarious larval settlement for juvenile corals under ocean warming and acidification, and highlight the ecological role of larval settlement behavior in mediating the responses of coral recruits to climate change stressors.

Spatio-temporal analysis of east greenland polar front - Yu Liu; Jianhui Wang; Guoqing Han; Xiayan Lin; Guijing Yang; Qiyan Ji (Frontiers in Marine Science, 2022)
The East Greenland Polar Front (EGPF) is an important front with strong salinity and temperature gradients in the Nordic Seas. It is formed by the interaction between Arctic-origin and Atlantic-origin water. The variations of EGPF are closely linked with sea ice melting and heat content transport associated with North Atlantic water recirculation. For a three-dimensional (3D) daily analysis, we use the global ocean eddy resolution reanalysis product (GLORYS12V1) from 1993 to 2018 to calculate the salinity and temperature horizontal gradient in the upper ocean and obtain the spatiotemporal distribution and intensity characteristics of EGPF. After assessment, the thresholds of the salinity and temperature fronts are set to 0.04 psu/km and 0.09°C/km, respectively. Compared with satellite observations of sea ice concentration, a significant spatial relationship is observed between the main position of EGPF and the ice edge before the sea ice shrinks to the continental shelf sea area. Affected by the freshening of the Arctic-origin water due to the melting of the sea ice, the intensity and area of EGPF show significant seasonal variations. Against the background of global warming, the sea ice area presents an obvious decreasing trend in the Greenland Sea. The melting of sea ice increased annually every summer from 1998 to 2018. The heat content transport of the Atlantic-origin water has also increased in recent years. The 3D characteristics (intensity and volume) of EGPF as salinity and temperature fronts exhibit increasing trends.

Shallow-water hydrothermal vent system as an extreme proxy for discovery of microbiome significance in a crustacean holobiont - Ling Chiu; Min-Chen Wang; Kuang-Yu Tseng; Chih-Lin Wei; Huei-Ting Lin; Shan-Hua Yang; Yung-Che Tseng (Frontiers in Marine Science, 2022)
The shallow-water hydrothermal vent (HV) system off Kueishan Island lies at the end of the Okinawa Trough to the northeast of Taiwan. Near its submarine vent openings, aperiodic vent discharges generate a dynamic acidic (pH 5.5-8.1) and sulfidic (9-3000 μM) ecosystem. The dominant metazoan in this unique environment is the brachyuran vent crab, Xenograpsus testudinatus , which has developed robust metabolic strategies and highly adaptive acid-base regulatory mechanisms to maintain its physiological homeostasis. X. testudinatus is considered a holobiont, but the symbiotic mechanisms underlying acid and sulfur tolerance in the host-microbe system remain largely unclear. In this study, we used LoopSeq long-read sequencing of the full-length 16S rRNA gene to identify the bacterial communities present in the gills and carapace surface of X. testudinatus . The alpha diversity analysis, Venn diagram, and principal coordinate analysis (PCoA) indicated that the gills and carapace surface exhibit different bacterial constituents. Further measurements of relative abundance, coupled with functional predictions and fluorescence in situ hybridization (FISH), revealed a predominance of Sulfurovum sp. NBC37-1, a key bacterium that can perform sulfur and hydrogen oxidation to support denitrification processes. Consequently, our findings suggest that the symbiotic bacteria may play a critical role in conferring the extraordinary acid and sulfur tolerances of X. testudinatus , allowing the crustacean holobiont to thrive in its ecological niche within one of the most extreme marine habitats on Earth.

Altered Retinal Dopamine Levels in a Melatonin-proficient Mouse Model of Form-deprivation Myopia - Kang-Wei Qian; Yun-Yun Li; Xiao-Hua Wu; Xue Gong; Ai-Lin Liu; Wen-Hao Chen; Zhe Yang; Ling-Jie Cui; Yun-Feng Liu; Yuan-Yuan Ma; Chen-Xi Yu; Furong Huang; et al. (Neuroscience Bulletin, 2022)

Catalytic effect of cesium on the oxidation behavior of cation exchange resins in Li2CO3-Na2CO3-K2CO3 melt - Yang-Hai Zheng; Yong-De Yan; Yun Xue; Yue-Lin Wang; Xin Liu; Wan-Sheng Mi; Qing-Guo Zhang; Yu Li; Fu-Qiu Ma; Mi-Lin Zhang; Zhi-Hao Gan; Kai Zhu (Environmental Science and Pollution Research, 2022)

Green finance, technological progress, and ecological performance—evidence from 30 Provinces in China - Lin Ge; Haoxiang Zhao; Junyao Yang; Jingyue Yu; Taiyi He (Environmental Science and Pollution Research, 2022)

ZAKβ Alleviates Oxidized Low-density Lipoprotein (ox-LDL)-Induced Apoptosis and B-type Natriuretic Peptide (BNP) Upregulation in Cardiomyoblast - Yueh-Min Lin; Jiro Hasegawa Situmorang; Jia-Zun Guan; Dennis Jine-Yuan Hsieh; Jaw-Ji Yang; Michael Yu-Chih Chen; Ching-Hui Loh; Chia-Hua Kuo; Shang-Yeh Lu; Ying-Ming Liou; Chih-Yang Huang (Cell Biochemistry and Biophysics, 2022)

Mapping the potential for offshore aquaculture of salmonids in the Yellow Sea - Shuang-En Yu; Shuang-Lin Dong; Zhi-Xin Zhang; Yu-Yang Zhang; Gianluca Sarà; Jie Wang; Yun-Wei Dong (Marine Life Science & Technology, 2022)
Mariculture has been one of the fastest-growing global food production sectors over the past three decades. With the congestion of space and deterioration of the environment in coastal regions, offshore aquaculture has gained increasing attention. Atlantic salmon ( Salmo salar ) and rainbow trout ( Oncorhynchus mykiss ) are two important aquaculture species and contribute to 6.1% of world aquaculture production of finfish. In the present study, we established species distribution models (SDMs) to identify the potential areas for offshore aquaculture of these two cold-water fish species considering the mesoscale spatio-temporal thermal heterogeneity of the Yellow Sea. The values of the area under the curve (AUC) and the true skill statistic (TSS) showed good model performance. The suitability index (SI), which was used in this study to quantitatively assess potential offshore aquaculture sites, was highly dynamic at the surface water layer. However, high SI values occurred throughout the year at deeper water layers. The potential aquaculture areas for S. salar and O. mykiss in the Yellow Sea were estimated as 52,270 ± 3275 (95% confidence interval, CI) and 146,831 ± 15,023 km 2 , respectively. Our results highlighted the use of SDMs in identifying potential aquaculture areas based on environmental variables. Considering the thermal heterogeneity of the environment, this study suggested that offshore aquaculture for Atlantic salmon and rainbow trout was feasible in the Yellow Sea by adopting new technologies (e.g., sinking cages into deep water) to avoid damage from high temperatures in summer.

CREB1 contributes colorectal cancer cell plasticity by regulating lncRNA CCAT1 and NF-κB pathways - Bin Li; Lisi Zheng; Jiayi Ye; Chenmin Zhang; Jie Zhou; Qiaojuan Huang; Yanhua Guo; Luqin Wang; Peng Yu; Shurong Liu; Qiao Lin; Yuxia Luo; et al. (Science China Life Sciences, 2022)

Biomechanical Analysis of Mandibular Implant-Assisted Removable Partial Denture with Distal Extension - Yung-Chung Chen; Chi-Lun Lin; Chen-Han Yu; Hung-Chih Chang; Yang-Ming Lin; Jia-Wei Lin (Journal of Medical and Biological Engineering, 2022)

Effects of ambient air pollution on glycosylated hemoglobin: a systematic review and meta-analysis - Li Tian; Mengqi Sun; Lisen Lin; Yan Wang; Yang Yu; Junchao Duan; Zhiwei Sun (Environmental Science and Pollution Research, 2022)

Lelliottia steviae sp. nov. isolated from Stevia rebaudiana Bertoni - Jing Lin; Ke Huang; Jing-Yu Huang; Yuan-Ru Xiong; Meng-Meng Wei; Na Xiao; Jia Gao; Xuan-Kai Ding; Zi-Yang Ma; Jun-Hao Sang; Ling-Xian Kong; Zhi-Yun Hong; et al. (Archives of Microbiology, 2022)

Rhodohalobacter sulfatireducens sp. nov., isolated from a marine solar saltern - Yu-Sheng Wang; Yu-Yan Yue; Yi-Lin Bai; Xu-Yang Zhang; Shuo Wang; Zong-Jun Du (Archives of Microbiology, 2022)

Fissistiganoids A and B: two new flavonoids from the Fissistigma tungfangense - Wan-Lin Zhong; Xue-Ming Zhou; Ji-Ling Yi; Xin-Ming Song; Bin Zhang; Jing-Yu Yang; Guang-Ying Chen (Natural Product Research, 2022)

High-Throughput Identification of Antihypertensive Peptides (AHTPs) and Characterization of AHTP-Derived Genes in the Lined Seahorse (Hippocampus erectus) - Yu Huang; Xiyang Chen; Haoyue Shu; Panpan Xiao; Xueqiang Lin; Junmin Xu; Chao Bian; Xinxin You; Jian Yang; Qiong Shi (Frontiers in Marine Science, 2022)
Recently, the prevalence of hypertension has become a global challenge. Therefore, tremendous efforts have been made to identify and purify antihypertensive peptides (AHTPs) from food-derived proteins to aid the discovery of new hypotensive drugs with fewer side effects. In this study, we performed high-throughput prediction of AHTPs based on multi-omics data, providing an overview of AHTPs in the lined seahorse proteins and suggesting their potential application as bioactive agents to lower blood pressure. We identified 14,695 AHTP-derived genes in the lined seahorse, and most of them were supported by transcriptomic evidence, whereas only 495 genes were further detected by proteome sequencing. Among these predicted AHTP-derived genes, the longest titin had the most hits with 104 AHTPs, some of which were clustered in exon 158, 194, and 204. Another AHTP-rich group was in the collagen family, and four AHTP-rich collagens exhibited much higher transcription in the pouch than in other examined tissues, including brain, testis, and embryos. Additionally, antihypertensive triplets, comprised of the permutations of Gly, Pro, and Lys, prevailed in all collagen sequences due to the representative XaaYaaGly repeat units. In summary, our present findings provide a solid basis for understanding the abundance of various AHTPs in the lined seahorse as well as shed light on the development of antihypertensive products and drugs using seahorses as an important resource.

Metatranscriptomic analysis of host response and vaginal microbiome of patients with severe COVID-19 - Meng Xiao; Bo Lu; Rui Ding; Xia Liu; Xian Wu; Yaqian Li; Xudong Liu; Lin Qiu; Zhibo Zhang; Jing Xie; Yu Chen; Dong Zhang; et al. (Science China Life Sciences, 2022)

Dataset-based assessment of heavy metal contamination in freshwater fishes and their health risks - Xiao-Bo Liu; Congtian Lin; Yang-Yu Wu; Hai-Ning Huang; Li-Ting Zhu; Ru Jiang; Qiansheng Huang (Environmental Science and Pollution Research, 2022)

Aquapteridospora jiangxiensis, a new aquatic hyphomycetous fungus from a freshwater habitat in China - Su-Qin Peng; Yu-Lin Liu; Jun-En Huang; Xiao-Hong Li; Xin-Yi Yan; Hai-Yan Song; Yang Gao; Zhi-Jun Zhai; Yuan-Qiu Liu; Dian-Ming Hu (Archives of Microbiology, 2022)

Estrogenic and anti-neutrophilic inflammatory phenanthrenes from Juncus effusus L. - Hao-Chun Hu; Yi-Hong Tsai; Yu-Che Chuang; Kuei-Hung Lai; Yu-Ming Hsu; Tsong-Long Hwang; Chih-Chan Lin; Ferenc Fülöp; Yang-Chang Wu; Szu-Yin Yu; Yu-Ting Kuo; Fang-Rong Chang (Natural Product Research, 2022)

Association between MAP3K4 gene polymorphisms and the risk of schizophrenia susceptibility in a Northeast Chinese Han population - Yang Sun; Ye Lv; Hui-Wen Ren; Guan-Yu Wang; Li-Na Xuan; Yi-Yang Luo; Zhi-Lin Luan (Metabolic Brain Disease, 2022)

Breast Cancer Awareness Based on Health Information Literacy and Influential Factors among Female Nursing Students in China - Shu Yang; Ping Li; Lin Yu; Na Liu; Jie Wang; Pingping Guo; Xuehui Zhang; Wei Zhang (Journal of Cancer Education, 2022)

Estrogen Deficiency Aggravates Fluoride-Induced Liver Damage and Lipid Metabolism Disorder in Rats - Ya-ming Yu; Bian-hua Zhou; Yi-lin Yang; Cheng-Xiang Guo; Jing Zhao; Hong-wei Wang (Biological Trace Element Research, 2022)

Intelligent identification method and application of seismic faults based on a balanced classification network - Jing Yang; Ren-Wei Ding; Hui-Yong Wang; Nian-Tian Lin; Li-Hong Zhao; Shuo Zhao; Yu-Jie Zhang (Applied Geophysics, 2022)

Massive Heat Shock Protein 70 Genes Expansion and Transcriptional Signatures Uncover Hard Clam Adaptations to Heat and Hypoxia - Zhi Hu; Hao Song; Jie Feng; Cong Zhou; Mei-Jie Yang; Pu Shi; Zheng-Lin Yu; Yong-Ren Li; Yong-Jun Guo; Hai-Zhou Li; Tao Zhang (Frontiers in Marine Science, 2022)
Heat shock protein 70 (HSP70) members participate in a wide range of housekeeping and stress-related activities in eukaryotic cells. In marine ecosystems, bivalves encounter abiotic stresses, including high temperatures and low dissolved oxygen. Here, 133 MmHSP70 genes were identified through combined methods including Blastp, HMM and manual filtration, based on the whole Mercenaria mercenaria genome. The MmHSP70 genes were unevenly distributed, and 41 genes (33.08%) were located on Chr 7. Phylogenetic analyses indicated that the MmHSP70 gene family mainly consisted of two clusters and the Hspa12 subfamily underwent lineage-specific expansion. A high-density collinear gene block was observed between M. mercenaria Chr 7 and Cyclina sinensis Chr 14. Tandem duplication MmHSP70 gene pairs experienced different levels of purifying selection, which could be an important source of sequence and functional constraints. MmHSP70 genes showed tissue-specific and stress-specific expression. Most tandem duplication HSP70 gene pairs had high expression under hypoxia stress. HSP70 B2 tandem duplication gene pairs showed significantly increased expression under heat plus severe hypoxia stress. This study provided a comprehensive understanding of the MmHSP70 gene family in the M. mercenaria and laid a significant foundation for further studies on the functional characteristics of MmHSP70 genes during exposure to heat and hypoxia stress.

Shear Instability and Turbulent Mixing in the Stratified Shear Flow Behind a Topographic Ridge at High Reynolds Number - Jia-Lin Chen; Xiao Yu; Ming-Huei Chang; Sen Jan; Yiing Jang Yang; Ren-Chieh Lien (Frontiers in Marine Science, 2022)
Observations on the lee of a topographic ridge show that the turbulence kinetic energy (TKE) dissipation rate due to shear instabilities is three orders of magnitude higher than the typical value in the open ocean. Laboratory-scale studies at low Reynolds number suggest that high turbulent dissipation occurs primarily within the core region of shear instabilities. However, field-scale studies indicate that high turbulence is mainly populated along the braids of shear instabilities. In this study, a high-resolution, resolving the Ozmidov-scale, non-hydrostatic model with Large Eddy Simulation (LES) turbulent closure is applied to investigate dominant mechanisms that control the spatial and temporal scales of shear instabilities and resulting mixing in stratified shear flow at high Reynolds number. The simulated density variance dissipation rate is elevated in the cusp-like bands of shear instabilities with a specific period, consistent with the acoustic backscatter taken by shipboard echo sounder. The vertical length scale of each cusp-like band is nearly half of the vertical length scale of the internal lee wave. However, it is consistent with instabilities originating from a shear layer based on linear stability theory. The model results indicate that the length scale and/or the period of shear instabilities are the key parameters to the mixing enhancement that increases with lateral Froude number Fr L , i.e. stronger shear and/or steeper ridge.

The Fishery Value Chain Analysis in Taiwan - Tsung-Yu Yang; Hsing-Chun Lin; Wen-Hong Liu (Fishes, 2022)
Although the GDP of the fishery sector accounts for less than 0.3% of Taiwan’s GDP, there are many secondary and tertiary industries related to fisheries that add great value to the country’s economy. Therefore, when analyzing and calculating the output value and value added of the fishery sector, the relevance of these upstream and downstream industries should be considered jointly, and the value chain of the fishery industry should be studied and analyzed in order to truly present the value added created by fishery. This study aims to do this by first analyzing not only the primary fishery industry, but the value chain of the fishery industry at different stages such as fishery production, marine fishing, aquaculture, fishery processing, retail and services, and supportive systems. Then the value added of the whole fishery value chain to Taiwan’s GDP is estimated by using the Leontief input–output model, from the perspective of industry linkages and covering the period from 2011 to 2018. The empirical results suggest that the value added created by fishery and related industries accounted for 2.96% of the GDP in 2011, which rose to 3.11% in 2014, fell to 2.87% in 2015, rose to 2.93% in 2017, and fell to 2.84% in 2018. From 2011 to 2018, the amount of value added created by fisheries and related industries rose from NT$ 422.8 billion to NT$ 520.9 billion. The primary fishery sector has the largest contribution, followed by the fishery input sector, and transportation and sale service sector, and the fishery product processing sector has the lowest contribution rate. The empirical results provide important implications and references to the policy makers.

Effects of Involuntary and Voluntary Exercise in Combination with Acousto-Optic Stimulation on Adult Neurogenesis in an Alzheimer's Mouse Model - Wan-yi Li; Jun-yan Gao; Su-Yang Lin; Shao-tao Pan; Biao Xiao; Yu-tao Ma; Kai Xie; Wei Shen; Zhi-tao Liu; Guang-yu Li; Jie-jie Guo; Qin-wen Wang; et al. (Molecular Neurobiology, 2022)

Identification of PDXDC1 as a novel pleiotropic susceptibility locus shared between lumbar spine bone mineral density and birth weight - Yu-Qian Song; Shi-Di Hu; Xu Lin; Xiang-He Meng; Xiao Wang; Yin-Hua Zhang; Cheng Peng; Rui Gong; Tao Xu; Tong Zhang; Chen-Zhong Li; Dao-Yan Pan; et al. (Journal of Molecular Medicine, 2022)
An increasing number of epidemiological studies have suggested that birth weight (BW) may be a determinant of bone health later in life, although the underlying genetic mechanism remains unclear. Here, we applied a pleiotropic conditional false discovery rate (cFDR) approach to the genome-wide association study (GWAS) summary statistics for lumbar spine bone mineral density (LS BMD) and BW, aiming to identify novel susceptibility variants shared between these two traits. We detected 5 novel potential pleiotropic loci which are located at or near 7 different genes ( NTAN1 , PDXDC1 , CACNA1G , JAG1 , FAT1P1 , CCDC170 , ESR1 ), among which PDXDC1 and FAT1P1 have not previously been linked to these phenotypes. To partially validate the findings, we demonstrated that the expression of PDXDC1 was dramatically reduced in ovariectomized (OVX) mice in comparison with sham-operated (SHAM) mice in both the growth plate and trabecula bone. Furthermore, immunohistochemistry assay with serial sections showed that both osteoclasts and osteoblasts express PDXDC1 , supporting its potential role in bone metabolism. In conclusion, our study provides insights into some shared genetic mechanisms for BMD and BW as well as a novel potential therapeutic target for the prevention of OP in the early stages of the disease development. Key messages We investigated pleiotropy-informed enrichment between LS BMD and BW. We identified genetic variants related to both LS BMD and BW by utilizing a cFDR approach. PDXDC1 is a novel pleiotropic gene which may be related to both LS BMD and BW. Elevated expression of PDXDC1 is related to higher BMD and lower ratio n-6/n-3 PUFA indicating a bone protective effect of PDXDC1.

Technology imports, independent innovation, and China’s green economic efficiency: an analysis based on spatial and mediating effect - Xiao Zheng; Hong Yu; Lin Yang (Environmental Science and Pollution Research, 2022)

Hypothermal Effects on Energy Supply for Ionocytes in Gills of Freshwater- and Seawater-Acclimated Milkfish, Chanos chanos - Chia-Hao Chang; Chia-Jui Liu; Wei-Jie Lu; Li-Yang Wu; Kuang-Jie Lai; Yu-Ting Lin; Tsung-Han Lee (Frontiers in Marine Science, 2022)
The milkfish, Chanos chanos , is an important aquaculture species that can be cultured in freshwater (FW) and seawater (SW) ponds because of its high euryhalinity. In winter, cold snap leading to high mortality of this tropical species is a critical issue for the aquaculture industry in Taiwan. Under hypothermal stress, however, changes in energy supply for osmoregulation of this euryhaline species is intriguing. In this study, we used an antibody against glycogen phosphorylase (GP) to identify glycogen-rich (GR) cells distributed adjacent to the mitochondria-rich (MR) ionocytes in milkfish gills. Glucose transporter 1 (GLUT1), which plays a major role in energy supply, was also identified and localized in GR cells. Moreover, the expression of indicators of aerobic metabolism and energy production, citrate synthase (CS) and cytochrome c oxidase (COX), were analyzed in gills of FW- and SW-acclimated milkfish to reveal different strategies of energy utilization under hypothermal stress. When exposed to a low-temperature environment, SW individuals used branchial glycogen and lactate to match the energy demands of aerobic metabolism in ionocytes, and elevated aerobic capacity to support and maintain normal functions in gills. However, branchial glycogen mainly localized in the GR cells of FW milkfish was not utilized under hypothermal stress. Meanwhile, a similar level of branchial COX activity and COXIV protein abundance at low temperatures between FW and SW milkfish indicated similar energy requirements in gills. This suggested that another source, but not branchial glycogen, maintained the energy demand in FW milkfish. The present study illustrated differential energy supply strategies in gills between SW- and FW-acclimated milkfish for osmoregulation under low temperatures.

Ocean Currents May Influence the Endolithic Bacterial Composition in Coral Skeletons - Po-Yu Liu; Sung-Yin Yang; Chih-Ying Lu; Naohisa Wada; Stéphane De Palmas; Shu-Shuo Yeh; Hideyuki Yamashiro; Sen-Lin Tang; Shan-Hua Yang (Frontiers in Marine Science, 2022)
Coral endolithic microbes can be an important nutrients support for hosts while under stresses. Previous studies have found that the endolithic microbial composition of a single coral species can be biogeographical diverse. However, the potential environmental factors, such as salinity, temperature, pH, and nutrient, that might influence the composition of the endolithic microbes remain unclear. In this study, we used both amplicon sequence variants (ASV) and a kmer-based taxonomic unit (KTU) to characterize the endolithic bacterial constitution of Isopora spp. located in the western Pacific Ocean—where it is subjected to the Kuroshio Current (in Okinawa, Japan and Green Island, Taiwan)—and the South China Sea (Dongsha Atoll). The endolithic bacterial community compositions showed a significant geographical difference, and we suggest that the ocean current and primary productivity are the most essential environmental factors influencing the bacterial communities in the skeleton of Isopora spp. In addition, our results showed that, technically, compared to ASV, bacterial composition based on KTU avoids extreme data, making it a suitable tool for explaining the associations between microbes and environmental factors.

Production of sesquiterpene patchoulol in mitochondrion-engineered Saccharomyces cerevisiae - Xin-Yi Tao; Yang-Chen Lin; Feng-Qing Wang; Qing-Hai Liu; Yu-Shu Ma; Min Liu; Dong-Zhi Wei (Biotechnology Letters, 2022)

The significance of riparian communities in the energy flow of subtropical stream ecosystems - Yi-Chang Liao; An-Cheng Lin; Han-Ni Tsai; Yu-Ting Yen; Chyng-Shyan Tzeng; Man-Miao Yang; Hsing-Juh Lin (Aquatic Sciences, 2022)

Spinal epidural angiolipoma with a special pattern of calcification misdiagnosed as meningioma - Jie Liu; Yu Lin; Jiabo Li; Jikang Fan; Xuejun Yang (Acta Neurologica Belgica, 2022)

Modulation of observed sea surface temperature variation by the quasi‐biweekly oscillation in the tropical western Pacific during boreal summer - Yang Yang; Kuiping Li; Weidong Yu; Yongcan Zu; Lin Liu (International Journal of Climatology, 2022)
Using 17‐year in situ buoy observations, this study investigates how sea surface temperature (SST) over the tropical western Pacific Ocean is modulated by the quasi‐biweekly oscillation (QBWO) during boreal summer. The 10‐buoy mean phase‐by‐phase composites of SST indicate that SST evolution lags behind the convection cycle by approximately one quarter, with the maximum SST occurring in Phase −90° (29.68°C) and the minimum SST occurring in Phase 90° (29.37°C). The diurnal cycle of SST (dSST) is in phase with the convection cycle, with the minimum dSST occurring during the convectively active phase (0.34°C) and the maximum dSST occurring during the convectively suppressed phase (0.61°C). The fluctuation in the dSST reaches 0.27°C, which is similar to that in the SST (0.31°C). This kind of oscillation can be well explained by the evolution of the sea surface forcing parameters, especially the shortwave radiation and wind speeds, observed from the buoys. In addition, the composite range of the dSST suggests an interesting asymmetry between Phase −90° and 90°. The interaction of the background summer mean state and the 10–30‐day intraseasonal anomalies causes the asymmetry in wind speed between Phase −90° and 90°, which in turn results in the asymmetry in the dSST between these two phases. Since QBWOs are more likely to occur during El Niño developing summers than during El Niño decaying summers, the 10–30‐day intraseasonal SST and dSST variances during El Niño developing summers are stronger than those during El Niño decaying summers.

Anti-inflammatory constituents from Phyllostachys makinoi Hayata - Chia-Ching Liaw; Yu-Chi Lin; Shao-Yu Wu; Jenny Chun-Ling Kuo; Zhi-Hu Lin; Kai-Wei Lin; Huang Hui-Chi; Li-Ming Yang Kuo; Yao-Haur Kuo (Natural Product Research, 2022)

Effects of azadirachtin on detoxification-related gene expression in the fat bodies of the fall armyworm, Spodoptera frugiperda - Haikuo Yu; Xianmei Yang; Jinghua Dai; Yuning Li; Sethuraman Veeran; Jintian Lin; Benshui Shu (Environmental Science and Pollution Research, 2022)

Morphological and phylogenetic analysis of a new Melosira species and revision of freshwater Melosira in China - Lin Yang; Pan Yu; Qingmin You; Guisheng Li; Quanxi Wang (Journal of Oceanology and Limnology, 2022)

Establishment of Galectin-3 Time-resolved Fluoroimmunoassay and its Application in Idiopathic Membranous Nephropathy - Xiaomei Yu; Lingli Chen; Bo Lin; Li Zhang; Xue Yang; Xiaobin Liu; Pengguo Xia; Yueming Liu; Shaoxiong Zheng; Xiumei Zhou; Yigang Wang; Yuan Qin; et al. (Journal of Fluorescence, 2022)

Early-Middle Permian carbon-isotope stratigraphy of marine carbonates in the northern edge of the South China: implications for global correlation - Qian Li; Karem Azmy; Shuai Yang; Hongde Chen; Shenglin Xu; Liangbiao Lin; Zhongtang Su; Anqing Chen; Yu Yu; Fengrui Sun (Carbonates and Evaporites, 2022)

Prevalence, complete genome, and metabolic potentials of a phylogenetically novel cyanobacterial symbiont in the coral‐killing sponge, Terpios hoshinota - Yu‐Hsiang Chen; Hsing‐Ju Chen; Cheng‐Yu Yang; Jia‐Ho Shiu; Daphne Z. Hoh; Pei‐Wen Chiang; Wenhua Savanna Chow; Chaolun Allen Chen; Tin‐Han Shih; Szu‐Hsien Lin; Chi‐Ming Yang; James Davis Reimer; et al. (Environmental Microbiology, 2022)
Summary Terpios hoshinota is an aggressive, space‐competing sponge that kills various stony corals. Outbreaks of this species have led to intense damage to coral reefs in many locations. Here, the first large‐scale 16S rRNA gene survey across three oceans revealed that bacteria related to the taxa Prochloron , Endozoicomonas , SAR116, Ruegeria , and unclassified Proteobacteria were prevalent in T . hoshinota . A Prochloron ‐related bacterium was the most dominant and prevalent cyanobacterium in T . hoshinota . The complete genome of this uncultivated cyanobacterium and pigment analysis demonstrated that it has phycobiliproteins and lacks chlorophyll b , which is inconsistent with the definition of Prochloron . Furthermore, the cyanobacterium was phylogenetically distinct from Prochloron , strongly suggesting that it should be a sister taxon to Prochloron . Therefore, we proposed this symbiotic cyanobacterium as a novel species under the new genus Candidatus Paraprochloron terpiosi. Comparative genomic analyses revealed that ‘Paraprochloron’ and Prochloron exhibit distinct genomic features and DNA replication machinery. We also characterized the metabolic potentials of ‘Paraprochloron terpiosi’ in carbon and nitrogen cycling and propose a model for interactions between it and T. hoshinota . This study builds a foundation for the study of the T . hoshinota microbiome and paves the way for better understanding of ecosystems involving this coral‐killing sponge.

Functional characterization of melanocortin-3 receptor in rainbow trout (Oncorhynchus mykiss) - Hui-Xia Yu; Yang Li; Wei-Jia Song; Hui Wang; Hao-Lin Mo; Qiao Liu; Xin-Miao Zhang; Ze-Bin Jiang; Li-Xin Wang (Fish Physiology and Biochemistry, 2022)

Detection of pulmonary tuberculosis in children using the Xpert MTB/RIF Ultra assay on sputum: a multicenter study - Xiaoshan Peng; Qiong Liao; Min Fang; Yu Zhu; Yan Shi; Shuting Quan; Yacui Wang; Li Duan; Xiaomei Shi; Yang Liu; Manzhi Wang; Qingsong Wei; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2022)

Distinct durability of IgM/IgG antibody responses in COVID-19 patients with differing severity - Junyan Han; Ning Zhang; Danying Chen; Yuhuan Gong; Guoli Li; Yaxian Kong; Lin Pu; Chen Chen; Jingyuan Liu; Qi Wang; Ju Zhang; Xuesen Zhao; et al. (Science China Life Sciences, 2022)

MAPK5 and MAPK10 overexpression influences strawberry fruit ripening, antioxidant capacity and resistance to Botrytis cinerea - Yunting Zhang; Yu Long; Yiting Liu; Min Yang; Liangxin Wang; Xiaoyang Liu; Yong Zhang; Qing Chen; Mengyao Li; Yuanxiu Lin; Haoru Tang; Ya Luo (Planta, 2022)

Identification, evolutionary analysis and functional diversification of RAV gene family in cotton (G. hirsutum L.) - Nosheen Kabir; Hai Lin; Xianhui Kong; Le Liu; Ghulam Qanmber; YuXuan Wang; Lian Zhang; Zhuojing Sun; Zuoren Yang; Yu Yu; Na Zhao (Planta, 2022)

A novel alphahypovirus that infects the fungal plant pathogen Sclerotinia sclerotiorum - Weibo Liang; Zhongbo Lu; Jie Duan; Daohong Jiang; Jiatao Xie; Jiasen Cheng; Yanping Fu; Tao Chen; Bo Li; Xiao Yu; Weidong Chen; Yang Lin (Archives of Virology, 2022)

Nakamurella leprariae sp. nov., isolated from a lichen sample - De-Feng An; Shao-Juan Yang; Long-Qian Jiang; Xin-Yu Wang; Xiao-Yu Huang; Lei Lang; Xue-Mei Chen; Ming-Qun Fan; Gui-Ding Li; Ming-Guo Jiang; Li-Song Wang; Cheng-Lin Jiang; et al. (Archives of Microbiology, 2022)

The brown root rot fungus Phellinus noxius affects microbial communities in different root‐associated niches of Ficus trees - Tse‐Yen Liu; Chao‐Han Chen; Yu‐Liang Yang; Isheng J. Tsai; Ying‐Ning Ho; Chia‐Lin Chung (Environmental Microbiology, 2022)
Summary Brown root rot (BRR) caused by Phellinus noxius is a destructive tree disease in tropical and subtropical areas. To understand how BRR affects the composition of the plant rhizoplane‐enriched microbiota, the microbiomes within five root‐associated compartments (i.e., bulk soil, old/young root rhizosphere soil, old/young root tissue) of Ficus trees naturally infected by P. noxius were investigated. The level of P. noxius infection was determined by quantitative PCR. Illumina sequencing of the internal transcribed spacer and 16S rRNA revealed that P. noxius infection caused a significant reduction in fungal diversity in the bulk soil, the old root rhizosphere soil, and the old root tissue. Interestingly, Cosmospora was the only fungal genus positively correlated with P. noxius . The abundance and composition of dominant bacterial taxa such as Actinomadura , Bacillus , Rhodoplanes , and Streptomyces differed between BRR‐diseased and healthy samples. Furthermore, 838 isolates belonging to 26 fungal and 35 bacterial genera were isolated and tested for interactions with P. noxius . Antagonistic activities were observed for isolates of Bacillus , Pseudomonas , Aspergillus , Penicillium , and Trichoderma . Cellophane overlay and cellulose/lignin utilization assays suggested that Cosmospora could tolerate the secretions of P. noxius and that the degradation of lignin by P. noxius may create suitable conditions for Cosmorpora growth.

Energy dissipation and fatigue damage evolution of sandstone under different upper limit stresses - Yidan Sun; Zhiwei Lin; Yu Yang (Arabian Journal of Geosciences, 2021)

A New Instrumental Array in Sichuan, China, to Monitor Vibrations and Perturbations of the Lithosphere, Atmosphere, and Ionosphere - Chieh-Hung Chen; Yang-Yi Sun; Kai Lin; Chen Zhou; Rui Xu; Haiyin Qing; Yongxin Gao; Tao Chen; Fei Wang; Huaizhong Yu; Peng Han; Chi-Chia Tang; et al. (Surveys in Geophysics, 2021)

Evaluation of the antifungal activity of Lysurus mokusin extract against Pestalotiopsis neglecta and GC–MS analysis of the active components - Lian-Nan Lin; Jing Yang; Guo-Cai Zhang; Xiao-Bo Zhang; Ting-Yu Wang; De-Dong Wu (Journal of Plant Pathology, 2021)

The role of mechanical harvesting on the recession of aquatic vegetation under an extreme water level increase in a eutrophic shallow lake - Changtao Yang; Jing Nan; Jianhua Li; Yi Lin; Jie Yu; Jianbin Wu; Xiaobing Shen (Environmental Science and Pollution Research, 2021)

Evaluating the energy, health efficiency, and productivity in OECD - Ching-Cheng Lu; Yung-ho Chiu; Chih-Yu Yang; Tai-Yu Lin (Environmental Geochemistry and Health, 2021)

Wave-ice dynamical interaction: a numerical model and its application - Yang Zhang; Changsheng Chen; Guoping Gao; Jianhua Qi; Huichan Lin; Wei Yu; Liang Chang (Acta Oceanologica Sinica, 2021)

Chronic Exposure to Hypoxia Inhibits Myelinogenesis and Causes Motor Coordination Deficits in Adult Mice - Lin Chen; Shu-Yu Ren; Rui-Xue Li; Kun Liu; Jing-Fei Chen; Yu-Jian Yang; Yong-Bin Deng; Han-Zhi Wang; Lan Xiao; Feng Mei; Fei Wang (Neuroscience Bulletin, 2021)
Exposure to chronic hypoxia is considered to be a risk factor for deficits in brain function in adults, but the underlying mechanisms remain largely unknown. Since active myelinogenesis persists in the adult central nervous system, here we aimed to investigate the impact of chronic hypoxia on myelination and the related functional consequences in adult mice. Using a transgenic approach to label newly-generated myelin sheaths ( NG2-CreER TM ; Tau-mGFP ), we found that myelinogenesis was highly active in most brain regions, such as the motor cortex and corpus callosum. After exposure to hypoxia (10% oxygen) 12 h per day for 4 weeks, myelinogenesis was largely inhibited in the 4-month old brain and the mice displayed motor coordination deficits revealed by the beam-walking test. To determine the relationship between the inhibited myelination and functional impairment, we induced oligodendroglia-specific deletion of the transcription factor Olig2 by tamoxifen ( NG2-CreER TM ; Tau-mGFP; Olig2 fl/fl ) in adult mice to mimic the decreased myelinogenesis caused by hypoxia. The deletion of Olig2 inhibited myelinogenesis and consequently impaired motor coordination, suggesting that myelinogenesis is required for motor function in adult mice. To understand whether enhancing myelination could protect brain functions against hypoxia, we treated hypoxic mice with the myelination-enhancing drug-clemastine, which resulted in enhanced myelogenesis and improved motor coordination. Taken together, our data indicate that chronic hypoxia inhibits myelinogenesis and causes functional deficits in the brain and that enhancing myelinogenesis protects brain functions against hypoxia-related deficits.

Anti-miR33 therapy improved hepatopancreatic lipid and immune metabolism disorders in grass carp, Ctenopharyngodon idella - Rong-Hua Lu; Meng-Jun Lin; Feng Yang; Shen-zong Jia; Yu-Ru Zhang; Chao-Bin Qin; Xiao-Lin Meng; Guo-Xing Nie (Fish Physiology and Biochemistry, 2021)

Development of a dual-labeled, hydrolysis probe-based, real-time quantitative PCR assay for detection of both genotypes of duck circovirus-1 (DuCV-1) and DuCV-2 - Lin Zhang; Wenming Jiang; Fuyou Zhang; Yang Li; Jinping Li; Shaobo Liang; Xiaohui Yu; Cheng Peng; Shuo Liu; Jingjing Wang; Shuhong Sun; Hualei Liu (Virus Genes, 2021)

Stenotrophomonas strain CPCC 101271, an intestinal lifespan-prolonging bacterium for Caenorhabditis elegans that assists in host resistance to “Bacillus nematocida” colonization - Rui Han; Yu Wang; Yang Deng; Yuqin Zhang; Lin Zhang; Qiuhong Niu (Archives of Microbiology, 2021)
The soil-dwelling, opportunistic pathogenic bacterium "Bacillus nematocida" B16 exhibits strong killing activities against a variety of pathogenic nematodes via a “Trojan horse” mechanism that can kill worm species like Caenorhabditis elegans . The bacterial strain CPCC 101271 was previously isolated from the intestines of C. elegans that were recovered from natural habitats and can serve as a probiotic for C. elegans , while also assisting in resistance to infection by the pathogenic strain B16. In this study, the lifespan of C. elegans fed with strain CPCC 101271 cells was extended by approximately 40% compared with that of worms fed with Escherichia coli OP50 cells. In addition, the colonization of C. elegans by the pathogenic bacterium "B. nematocida" B16 was inhibited when pre-fed with strain CPCC 101271. Metagenomic sequence analysis of intestinal microbiota of C. elegans fed with strain CPCC 101271 and infected with B16 revealed that pre-feeding worms with CPCC 101271 improved the diversity of the intestinal bacteria. Moreover, community structure significantly varied in coordination with Stenotrophomonas spp. and Bacillus spp. abundances when competition between strains CPCC 101271 and B16 was evaluated. In conclusion, the nematode microbiota strain CPCC 101271 assisted in its host resistance to colonization by the pathogen "Bacillus nematocida" and can also promote life span-prolongation in C. elegans. These results underscore that understanding the interactions between C. elegans microbiota and pathogens can provide new insights into achieving effective biological control of agricultural pests.

Plant multiscale networks: charting plant connectivity by multi-level analysis and imaging techniques - Xi Zhang; Yi Man; Xiaohong Zhuang; Jinbo Shen; Yi Zhang; Yaning Cui; Meng Yu; Jingjing Xing; Guangchao Wang; Na Lian; Zijian Hu; Lingyu Ma; et al. (Science China Life Sciences, 2021)

Magnetic Resonance Imaging-Guided and Navigated Individualized Repetitive Transcranial Magnetic Stimulation for Cognitive Impairment in Schizophrenia - Xu-Sha Wu; Tian-Cai Yan; Xian-Yang Wang; Yang Cao; Xiao-Fan Liu; Yu-Fei Fu; Lin Wu; Yin-Chuan Jin; Hong Yin; Long-Biao Cui (Neuroscience Bulletin, 2021)

The ATP Level in the mPFC Mediates the Antidepressant Effect of Calorie Restriction - Qian Wang; Ying Kong; Song Lin; Ding-Yu Wu; Jian Hu; Lang Huang; Wen-Si Zang; Xiao-Wen Li; Jian-Ming Yang; Tian-Ming Gao (Neuroscience Bulletin, 2021)

miR-145-5p targets paxillin to attenuate angiotensin II-induced pathological cardiac hypertrophy via downregulation of Rac 1, pJNK, p-c-Jun, NFATc3, ANP and by Sirt-1 upregulation - Kuan-Ho Lin; V. Bharath Kumar; Tamilselvi Shanmugam; Marthandam Asokan Shibu; Ray-Jade Chen; Chia-Hua Kuo; Tsung-Jung Ho; V. Vijaya Padma; Yu-Lan Yeh; Chih-Yang Huang (Molecular and Cellular Biochemistry, 2021)

Integration of small RNAs, degradome, and transcriptome sequencing provides insights into the differences between Shizhu ginseng and Yuan ginseng - Mengyuan Peng; Yanlin Chen; Wenjuan Wang; Zhihua He; Wangqiang Dai; Zhiyun Lin; Zemin Yang; Mengjuan Gong; Yongqin Yin; Bin Han; Yu Zeng; Yingfang Wang (Journal of Plant Biochemistry and Biotechnology, 2021)
Panax ginseng is one of the most popular herbs which have been used as an important traditional Chinese medicine since ancient times. Yuan ginseng and Shizhu ginseng,which belong to P. ginseng , are widely used as substitutes for wild ginseng in clinical practice. Clinical practice has proved that the clinical efficacy of Shizhu ginseng is better than Yuan ginseng. However, current research cannot completely explain this phenomenon. Considering that small RNA may be one of the pharmacodynamic substances of P. ginseng , it is challenging to investigate differential miRNAs between Shizhu ginseng and Yuan ginseng. In this study, the transcriptome, small RNAome and degradome of P. ginseng were studied by high-throughput sequencing. A total of 63,875 unigenes and 43,950,137 small RNA clean reads were obtained from the roots of P. ginseng . Among 3206 differentially expressed genes, 1190 genes were up-regulated in Yuan ginseng when compared with Shizhu ginseng. 24 known differential miRNAs and 7 novel differential miRNAs were obtained. The 304 targets of 24 differentially expressed miRNA (17 known and 7 novel) families are mainly related to energy metabolism, biotic stress and disease immunity in ginseng itself. Through the association analysis of mRNA and miRNA, our work gives a better understanding of the difference between Yuan ginseng and Shizhu ginseng. Considering the cross-kingdom regulation of plant miRNAs, our results may provide a foundation for understanding the miRNA-dependent clinical efficacy in P. ginseng .

Multifunctional graphene-based nanocomposites for simultaneous enhanced photocatalytic degradation and photothermal antibacterial activity by visible light - Ya-kun Lv; Lin Mei; Liu-xue Zhang; De-hong Yang; Zi-yu Yin (Environmental Science and Pollution Research, 2021)

Use of housefly (Musca domestica L.) larvae to bioconversion food waste for animal nutrition and organic fertilizer - Zhang Cheng; Lin Yu; Hahan Li; Xiaoxun Xu; Zhanbiao Yang (Environmental Science and Pollution Research, 2021)

Bioaccumulation and translocation of trace elements in soil-irrigation water-wheat in arid agricultural areas of Xin Jiang, China - Muyesaier Tudi; Huada Daniel Ruan; Yunjiang Yu; Li Wang; Binggan Wei; Shuangmei Tong; Chang Kong; Lin-sheng Yang (Ecotoxicology, 2021)

Viable and Heat-Killed Probiotic Strains Improve Oral Immunity by Elevating the IgA Concentration in the Oral Mucosa - Wen-Yang Lin; Yi-Wei Kuo; Ching-Wei Chen; Yu-Fen Huang; Chen-Hung Hsu; Jia-Hung Lin; Cheng-Ruei Liu; Jui-Fen Chen; Ko-Chiang Hsia; Hsieh-Hsun Ho (Current Microbiology, 2021)
Oral-nasal mucosal immunity plays a crucial role in protecting the body against bacterial and viral invasion. Safe probiotic products have been used to enhance human immunity and oral health. In this study, we verified the beneficial effects of mixed viable probiotic tablets, consisting of Lactobacillus salivarius subsp. salicinius AP-32, Bifidobacterium animalis subsp. lactis CP-9, and Lactobacillus paracasei ET-66, and heat-killed probiotic tablets, consisting of L. salivarius subsp. salicinius AP-32 and L. paracasei ET-66, on oral immunity among 45 healthy participants. Participants were randomly divided into viable probiotic, heat-killed probiotic, and placebo groups. The administration of treatment lasted for 4 weeks. Saliva samples were collected at Weeks 0, 2, 4, and 6, and Lactobacillus , Bifidobacterium and Streptococcus mutans populations and IgA concentration were measured. IgA concentrations, levels of TGF-beta and IL-10 in PBMCs cells were quantified by ELISA method. Results showed that salivary IgA levels were significantly increased on administration of both the viable (119.30 ± 12.63%, *** P < 0.001) and heat-killed (116.78 ± 12.28%, *** P < 0.001) probiotics for 4 weeks. Among three probiotic strains, AP-32 would effectively increase the levels of TGF-beta and IL-10 in PBMCs. The oral pathogen Streptococcus mutans was significantly reduced on viable probiotic tablet administration (49.60 ± 31.01%, *** P < 0.001). The in vitro antibacterial test confirmed that viable probiotics effectively limited the survival rate of oral pathogens. Thus, this clinical pilot study demonstrated that oral probiotic tablets both in viable form or heat-killed form could exert beneficial effects on oral immunity via IL-10, TGB-beta mediated IgA secretion. The effective dosage of viable probiotic content in the oral tablet was 10 9 CFUs/g and the heat-killed oral tablet was 1 × 10 10 cells/g.

Effects of periodically varying codes on separation of multisource blended data - Meng-Yao Jiao; Tian-Yue Hu; Yang Liu; Zhen-Zhen Yu; Shang-Lin Liang; Li-Chao Liu; Ji-Wei (Applied Geophysics, 2021)

Wogonin Accelerates Hematoma Clearance and Improves Neurological Outcome via the PPAR-γ Pathway After Intracerebral Hemorrhage - Jianfeng Zhuang; Yucong Peng; Chi Gu; Huihui Chen; Zheng Lin; Hang Zhou; Xiao Wu; Jianru Li; Xiaobo Yu; Yang Cao; Hanhai Zeng; Xiongjie Fu; et al. (Translational Stroke Research, 2021)

The major photoprotective role of anthocyanins in leaves of Arabidopsis thaliana under long-term high light treatment: antioxidant or light attenuator? - Xiao-Ting Zheng; Zheng-Chao Yu; Jun-Wei Tang; Min-Ling Cai; Yi-Lin Chen; Cheng-Wei Yang; Wah Soon Chow; Chang-Lian Peng (Photosynthesis Research, 2021)

Synthesis and biological evaluation of novel 1,3-diphenylurea quinoxaline derivatives as potent anticancer agents - Gui-Zhen Li; Xi-Lin Ouyang; Zu-Yu Mo; Yao Gu; Xiao-Lin Cao; Li Yang; Hai-Tao Tang; Ying-Ming Pan (Medicinal Chemistry Research, 2021)

Performance Comparison of the Deep Learning and the Human Endoscopist for Bleeding Peptic Ulcer Disease - Hsu-Heng Yen; Ping-Yu Wu; Pei-Yuan Su; Chia-Wei Yang; Yang-Yuan Chen; Mei-Fen Chen; Wen-Chen Lin; Cheng-Lun Tsai; Kang-Ping Lin (Journal of Medical and Biological Engineering, 2021)
Purpose Management of peptic ulcer bleeding is clinically challenging. Accurate characterization of the bleeding during endoscopy is key for endoscopic therapy. This study aimed to assess whether a deep learning model can aid in the classification of bleeding peptic ulcer disease. Methods Endoscopic still images of patients ( n = 1694) with peptic ulcer bleeding for the last 5 years were retrieved and reviewed. Overall, 2289 images were collected for deep learning model training, and 449 images were validated for the performance test. Two expert endoscopists classified the images into different classes based on their appearance. Four deep learning models, including Mobile Net V2, VGG16, Inception V4, and ResNet50, were proposed and pre-trained by ImageNet with the established convolutional neural network algorithm. A comparison of the endoscopists and trained deep learning model was performed to evaluate the model’s performance on a dataset of 449 testing images. Results The results first presented the performance comparisons of four deep learning models. The Mobile Net V2 presented the optimal performance of the proposal models. The Mobile Net V2 was chosen for further comparing the performance with the diagnostic results obtained by one senior and one novice endoscopists. The sensitivity and specificity were acceptable for the prediction of “normal” lesions in both 3-class and 4-class classifications. For the 3-class category, the sensitivity and specificity were 94.83% and 92.36%, respectively. For the 4-class category, the sensitivity and specificity were 95.40% and 92.70%, respectively. The interobserver agreement of the testing dataset of the model was moderate to substantial with the senior endoscopist. The accuracy of the determination of endoscopic therapy required and high-risk endoscopic therapy of the deep learning model was higher than that of the novice endoscopist. Conclusions In this study, the deep learning model performed better than inexperienced endoscopists. Further improvement of the model may aid in clinical decision-making during clinical practice, especially for trainee endoscopist.

Characteristics of bacterial community and ARGs profile in engineered goldfish tanks with stresses of sulfanilamide and copper - Benjamin Makimilua Tiimub; Zhen-chao Zhou; Lin Zhu; Yang Liu; Xin-Yi Shuai; Lan Xu; Christophe’ Niyungeko; Ling-Xuan Meng; Yu-Jie Sun; Hong Chen (Environmental Science and Pollution Research, 2021)

Geographic and subsequent biotic isolations led to a diversity anomaly of section Heterotropa (genus Asarum : Aristolochiaceae) in insular versus continental regions of the Sino‐Japanese Floristic Region - Daiki Takahashi; Shota Sakaguchi; Yu Feng; Yuji Isagi; Ying‐Xiong Qiu; Pan Li; Rui‐Sen Lu; Chang‐Tse Lu; Shih‐Wen Chung; Yang‐Shan Lin; Yun‐Chao Chen; Atsushi J. Nagano; et al. (Journal of Biogeography, 2021)
Aim The Sino‐Japanese Floristic Region has extremely high species diversity with respect to temperate plants; however, the reasons for this diversity are poorly understood because most studies have only considered geographic isolation caused by climatic oscillations. In some plant groups, high floral trait diversity and uneven species diversity between insular systems and the continental area suggest other factors may have important roles too. The primary purpose of this study is to reveal how abiotic and biotic factors have shaped the species diversity anomaly of Heterotropa between the insular systems and the continental area. Location The Sino‐Japanese Floristic Region. Taxon Section Heterotropa (genus Asarum ; Aristolochiaceae). Methods Using ddRAD‐seq and chloroplast genome data, we built a time‐calibrated phylogenetic tree including 79 species. We estimated the patterns of floral traits (flowering time and floral size) evolution using macroevolutionary modelling, and tested the correlation of speciation rate with the trait evolution rates. Finally, we estimated the isolation factors of all taxa pairs and sister‐taxa pairs based on distribution range and floral traits. Results Phylogenetic analysis indicated that Heterotropa was diverged into two clades (continental clade and insular clade) in the Miocene, and the major subclades corresponded to geographic entities. Most rate shifts accelerating floral trait's evolution occurred during the Pleistocene period. Evolution rate of floral traits showed positive correlation with the speciation rate. Large proportion of taxa in the insular clade are distributed allopatrically. Several sister pairs showed floral trait divergence with geographic overlap. Main Conclusions The diversification of Heterotropa appears to have been triggered by geographic and climatic events, and subsequent repeated floral trait evolution with and without geographic isolation. Furthermore, the high species diversity in the insular systems would have been formed by the repeated range fragmentations and contractions. Our study demonstrates the importance of multidimensional studies to understand the diversification process of temperate plants in the Sino‐Japanese Floristic Region.

The Characteristic of Critical Genes in Neuroendocrine System and Their Regulation on Food Habit Transition and Metamorphosis of Veined Rapa Whelk Rapana venosa (Valenciennes, 1846) - Mei-Jie Yang; Jie Feng; Hao Song; Zheng-Lin Yu; Pu Shi; Jian Liang; Zhi Hu; Cong Zhou; Xiao-Lin Wang; Tao Zhang (Frontiers in Marine Science, 2021)
Metamorphosis is a critical developmental event in mollusks, and neuroendocrine system plays an essential role in this process. Rapana venosa is an economically important shellfish in China, but the artificial technology of R. venosa aquaculture is limited by metamorphosis. As a carnivorous gastropod, food habit transition makes the mechanism of R. venosa metamorphosis more complex. To investigate the changes in the neuroendocrine system and to reveal its role in regulating the food habit transition and metamorphosis of R. venosa , we cloned the cDNA sequences encoding 5-hydroxytryptamine receptor ( Rv-5HTR ), nitric oxide synthetase ( Rv-NOS ) and cholecystokinin receptor ( Rv-CCKR ), and investigated their expression by quantitative real-time PCR analysis, and explore the spatio-temporal changes of 5-HT protein expression using Immunohistochemical (IHC) analysis. The expression of the three geens was significantly increased in the early intramembrane veliger stage, which indicates that the three genes are related to the development of digestive system. Additionally, expression of the three genes was decreased after metamorphosis, while Rv-NOS and Rv-CCKR were increasingly expressed in competent larvae, which may help the larvae find suitable environments and promote digestive system development for metamorphosis, and the result of 5-HT IHC analysis also reflects the development of neuroendocrine system. Furthermore, results show that CCK can effect the expression of digestive enzyme, NOS and 5-HT receptor. Finally, based on the present results, we hypothesized that CCK and CCK receptor may be critical regulatory factors of food habit transition and metamorphosis. These results might provide information on the development of neuroendocrine system of R. venosa , and new insight into the regulation of the food habit transition and metamorphosis of gastropods.

Collapsin response mediator protein 5 (CRMP5) modulates susceptibility to chronic social defeat stress in mice - Yu-Fen Lin; Kao Chin Chen; Yen Kuang Yang; Ya-Hsin Hsiao (Molecular Neurobiology, 2021)

Detection of Vestibular Schwannoma on Triple-parametric Magnetic Resonance Images Using Convolutional Neural Networks - Tzu-Hsuan Huang; Wei-Kai Lee; Chih-Chun Wu; Cheng-Chia Lee; Chia-Feng Lu; Huai-Che Yang; Chun-Yi Lin; Wen-Yuh Chung; Po-Shan Wang; Yen-Ling Chen; Hsiu-Mei Wu; Wan-You Guo; et al. (Journal of Medical and Biological Engineering, 2021)
Purpose The first step in typical treatment of vestibular schwannoma (VS) is to localize the tumor region, which is time-consuming and subjective because it relies on repeatedly reviewing different parametric magnetic resonance (MR) images. A reliable, automatic VS detection method can streamline the process. Methods A convolutional neural network architecture, namely YOLO-v2 with a residual network as a backbone, was used to detect VS tumors from MR images. To heighten performance, T1-weighted–contrast-enhanced, T2-weighted, and T1-weighted images were combined into triple-channel images for feature learning. The triple-channel images were cropped into three sizes to serve as input images of YOLO-v2. The VS detection effectiveness levels were evaluated for two backbone residual networks that downsampled the inputs by 16 and 32. Results The results demonstrated the VS detection capability of YOLO-v2 with a residual network as a backbone model. The average precision was 0.7953 for a model with 416 × 416-pixel input images and 16 instances of downsampling, when both the thresholds of confidence score and intersection-over-union were set to 0.5. In addition, under an appropriate threshold of confidence score, a high average precision, namely 0.8171, was attained by using a model with 448 × 448-pixel input images and 16 instances of downsampling. Conclusion We demonstrated successful VS tumor detection by using a YOLO-v2 with a residual network as a backbone model on resized triple-parametric MR images. The results indicated the influence of image size, downsampling strategy, and confidence score threshold on VS tumor detection.

Roles of bulk and rhizosphere denitrifying bacteria in denitrification from paddy soils under straw return condition - Ning Wang; Ya-Hui Zhao; Jian-Guang Yu; Li-Hong Xue; Hong-Bo Li; Lin-Zhang Yang (Journal of Soils and Sediments, 2021)

Diversity of Diaporthe species associated with melanose disease on citrus trees in Jiangxi Province, China - Zhe-Zheng Zeng; Chingchai Chaisiri; Xiang-Yu Liu; Yang Lin; Chao-Xi Luo (European Journal of Plant Pathology, 2021)

Preparation of Ce0.9Zr0.1O2/SnIn4S8 composite photocatalyst and its degradation of typical antibiotic pollutants - Yuancai Lv; Jianying Yu; Siyi Huang; Kaiyun Zheng; Guifang Yang; Yifan Liu; Chunxiang Lin; Xiaoxia Ye; Minghua Liu (Environmental Science and Pollution Research, 2021)

A dye combination for the staining of pollen coat and pollen wall - Xin-Lei Jia; Jing-Shi Xue; Fang Zhang; Chi Yao; Shi-Yi Shen; Chang-Xu Sui; Yu-Jia Peng; Qin-Lin Xu; Yi-Feng Feng; Wen-Jing Hu; Ping Xu; Zhong-Nan Yang (Plant Reproduction, 2021)

Cytotoxic p -terphenyls from the deep-sea-derived Aspergillus candidus - Yu-Kun Lin; Chun-Lan Xie; Cui-Ping Xing; Bao-Qu Wang; Xiao-Xue Tian; Jin-Mei Xia; Ling-Yun Jia; Ying-Ni Pan; Xian-Wen Yang (Natural Product Research, 2021)

Cytotoxic meroterpenoids from the marine sponge Dactylospongia elegans - Hao-Bing Yu; Zi-Fei Yin; Bin-Bin Gu; Jian-Peng Zhang; Shu-Ping Wang; Fan Yang; Hou-Wen Lin (Natural Product Research, 2021)

QTL mapping of the genetic basis of stem diameter in soybean - Chong-Yuan Sun; Yu-Ming Yang; Lin Jia; Xiao-Qian Liu; Huan-Qing Xu; Hai-Yan Lv; Zhong-Wen Huang; Dan Zhang (Planta, 2021)

Stoichiometric relations of C, N, and P in urban top soils in Nanjing, China, and their biogeochemical implications - Jin-Ling Yang; Da-Gang Yuan; Yu-Guo Zhao; Yue He; Gan-Lin Zhang (Journal of Soils and Sediments, 2021)

Exposed to Mercury-Induced Oxidative Stress, Changes of Intestinal Microflora, and Association between them in Mice - Yulan Zhao; Changming Zhou; Xiaoquan Guo; Guoliang Hu; Guyue Li; Yu Zhuang; Huabin Cao; Lin Li; Chonghong Xing; Caiying Zhang; Fan Yang; Ping Liu (Biological Trace Element Research, 2021)

Genome sequencing and functional annotation of Bacillus sp. strain BS-Z15 isolated from cotton rhizosphere soil having antagonistic activity against Verticillium dahliae - Zhong-Yi Chen; Xieerwanimu Abuduaini; Nuramina Mamat; Qi-Lin Yang; Meng-Jun Wu; Xin-Rui Lin; Ru Wang; Rong-Rong Lin; Wei-Jun Zeng; Huan-Chen Ning; He-Ping Zhao; Jin-Yu Li; et al. (Archives of Microbiology, 2021)

Selective Ferroptosis Inhibitor Liproxstatin-1 Attenuates Neurological Deficits and Neuroinflammation After Subarachnoid Hemorrhage - Yang Cao; Yin Li; Chao He; Feng Yan; Jian-Ru Li; Hang-Zhe Xu; Jian-Feng Zhuang; Hang Zhou; Yu-Cong Peng; Xiong-Jie Fu; Xiao-Yang Lu; Yuan Yao; et al. (Neuroscience Bulletin, 2021)

Microbiological profiles and antimicrobial resistance patterns of pediatric bloodstream pathogens in China, 2016–2018 - Yue Qiu; Junwen Yang; Yiping Chen; Jinhong Yang; Qingxiong Zhu; Chunhui Zhu; Shuangjie Li; Jing Liu; Chaomin Wan; Yu Zhu; Minxia Chen; Yi Xu; et al. (European Journal of Clinical Microbiology & Infectious Diseases, 2021)

Marinobacter shengliensis subsp. alexandrii Subsp. Nov., Isolated from Cultivable Phycosphere Microbiota of Highly Toxic Dinoflagellate Alexandrium catenella LZT09 and Description of Marinobacter shengliensis Subsp. shengliensis Subsp. Nov - Xi Yang; Rong Xiang; Nurhezreen Md Iqbal; Yu-Han Duan; Xiao-Ai Zhang; Lei Wang; Lin-Zeng Yu; Jia-Zhou Li; Ming-Fei Sun; Qiao Yang; Chun-Tian Zheng; Shen-Quan Liao (Current Microbiology, 2021)

Increased resting state functional irregularity of T2DM brains with high HbA1c: sign for impaired verbal memory function? - Xin Zhang; Ying Yu; Zhe-Sheng Shi; Ke Xu; Jia-Hao Feng; Ze-Yang Li; Xiang-Nan Zhang; Shu-Ning Shen; Yang Yang; Lin-Feng Yan; Jin Zhang; Qian Sun; et al. (Brain Imaging and Behavior, 2021)

Carbon isotope variations of modern soils in the eastern margin of the Tibetan Plateau and their controlling factors - Lin Qi; Yan-song Qiao; Zong-xiu Liu; Sha-sha Peng; Yu Cheng; Yan Wang; Xu-jiao Zhang; Ming-zhong Tian; Shuai-bin Yang; Wen-bin Bai (Journal of Mountain Science, 2021)

Dynamic Amplification of Gust-Induced Aerodynamic Loads Acting on a Wind Turbine during Typhoons in Taiwan - Tsung-Yueh Lin; Chun-Yu Yang; Shiu-Wu Chau; Jen-Shiang Kouh (Journal of Marine Science and Engineering, 2021)
Typhoons, such as Soudelor, which caused the collapse of several onshore wind turbines in 2015, pose a considerable challenge to Taiwan’s wind energy industry. In this study the characteristics of the aerodynamic loads acting on a wind turbine due to wind gusts in a typhoon are studied with a view to providing a proper definition of the S-Class wind turbine proposed in International Electrotechnical Commission (IEC) 61400-1. Furthermore, based on analysis of wind data during typhoons, as obtained from the meteorological mast in the Zhangbin coastal area, an extreme wind speed and gust model corresponding to the typhoon wind conditions in Taiwan are herein proposed. Finally, the flow fields around a parked wind turbine experiencing both an unsteady gust and a steady extreme wind were simulated by a numerical approach. Numerical results show that the aerodynamic shear force and overturning moment acting on the target wind turbine in a steady wind are significantly lower than those under an unsteady gust. The gust-induced amplification factors for aerodynamic loadings are then deduced from numerical simulations of extreme wind conditions.

Natural polyketide 6-pentyl-2 H -pyrone-2-one and its synthetic analogues efficiently prevent marine biofouling - Mo Aqib Raza Khan; Bo-Wei Wang; Yih-Yu Chen; Ting-Hsuan Lin; Hsiu-Chin Lin; Yu-Liang Yang; Ka-Lai Pang; Chih-Chuang Liaw (Biofouling, 2021)

Biopharmaceutics Applications of Physiologically Based Pharmacokinetic Absorption Modeling and Simulation in Regulatory Submissions to the U.S. Food and Drug Administration for New Drugs - Fang Wu; Heta Shah; Min Li; Peng Duan; Ping Zhao; Sandra Suarez; Kimberly Raines; Yang Zhao; Meng Wang; Ho-pi Lin; John Duan; Lawrence Yu; et al. (The AAPS Journal, 2021)

Delayed association of acute particulate matter 2.5 air pollution exposure with loss of complexity in cardiac rhythm dynamics: insight from detrended fluctuation analysis - Tsung-Ying Tsai; Li-Wei Lo; Shin-Huei Liu; Wen-Han Cheng; Yu-Hui Chou; Wei-Lun Lin; Yenn-Jiang Lin; Shih-Lin Chang; Yu-Feng Hu; Fa-Po Chung; Jo-Nan Liao; Tze-Fan Chao; et al. (Environmental Science and Pollution Research, 2021)

Polycyclic aromatic hydrocarbon and n-alkane pollution characteristics and structural and functional perturbations to the microbial community: a case-study of historically petroleum-contaminated soil - Jian Li; Ying Xu; Quanwei Song; Jie Yang; Lin Xie; Shihang Yu; Lei Zheng (Environmental Science and Pollution Research, 2021)

Kinesin-7 CENP-E regulates the formation and structural maintenance of the acrosome - Zhen-Yu She; Kai-Wei Yu; Ya-Lan Wei; Ning Zhong; Yang Lin (Cell and Tissue Research, 2021)

Warming Iron-Limited Oceans Enhance Nitrogen Fixation and Drive Biogeographic Specialization of the Globally Important Cyanobacterium Crocosphaera - Nina Yang; Carlin A. Merkel; Yu-An Lin; Naomi M. Levine; Nicholas J. Hawco; Hai-Bo Jiang; Ping-Ping Qu; Michelle A. DeMers; Eric A. Webb; Fei-Xue Fu; David A. Hutchins (Frontiers in Marine Science, 2021)
Primary productivity in the nutrient-poor subtropical ocean gyres depends on new nitrogen inputs from nitrogen fixers that convert inert dinitrogen gas into bioavailable forms. Temperature and iron (Fe) availability constrain marine nitrogen fixation, and both are changing due to anthropogenic ocean warming. We examined the physiological responses of the globally important marine nitrogen fixer, Crocosphaera watsonii across its full thermal range as a function of iron availability. At the lower end of its thermal range, from 22 to 27°C, Crocosphaera growth, nitrogen fixation, and Nitrogen-specific Iron Use Efficiencies (N-IUEs, mol N fixed hour –1 mol Fe –1 ) increased with temperature. At an optimal growth temperature of 27°C, N-IUEs were 66% higher under iron-limited conditions than iron-replete conditions, indicating that low-iron availability increases metabolic efficiency. However, Crocosphaera growth and function decrease from 27 to 32°C, temperatures that are predicted for an increasing fraction of tropical oceans in the future. Altogether, this suggests that Crocosphaera are well adapted to iron-limited, warm waters, within prescribed limits. A model incorporating these results under the IPCC RCP 8.5 warming scenario predicts that Crocosphaera N-IUEs could increase by a net 47% by 2100, particularly in higher-latitude waters. These results contrast with published responses of another dominant nitrogen fixer ( Trichodesmium ), with predicted N-IUEs that increase most in low-latitude, tropical waters. These models project that differing responses of Crocosphaera and Trichodesmium N-IUEs to future warming of iron-limited oceans could enhance their current contributions to global marine nitrogen fixation with rates increasing by ∼91 and ∼22%, respectively, thereby shifting their relative importance to marine new production and also intensifying their regional divergence. Thus, interactive temperature and iron effects may profoundly transform existing paradigms of nitrogen biogeochemistry and primary productivity in open ocean regimes.

Petrogenesis and tectonic significance of the Fenshuiling and Mengha granitic plutons, SW China: insights from bulk elements, zircon U-Pb ages and Sr-Nd-Hf isotopes - Chaoyi Dong; Gongjian Li; Huazhi Yu; Lin Yang; Huajian Li (International Geology Review, 2021)

Roles of FERONIA-like receptor genes in regulating grain size and quality in rice - Long Wang; Dandan Wang; Zhuhong Yang; Shun Jiang; Jianing Qu; Wei He; Zhenming Liu; Junjie Xing; Youchu Ma; Qinlu Lin; Feng Yu (Science China Life Sciences, 2021)

Soil anti-scourability enhanced by herbaceous species roots in a reservoir water level fluctuation zone - Wen-xiu Xu; Ling Yang; Yu-hai Bao; Jin-lin Li; Jie Wei (Journal of Mountain Science, 2021)

Experimental evidence for long‐term coexistence of copiotrophic and oligotrophic bacteria in pelagic surface seawater - Yi Li; Zhi‐Bin Wang; Xi‐Ying Zhang; Yan‐Ru Dang; Lin‐Lin Sun; Wei‐Peng Zhang; Hui‐Hui Fu; Gui‐Peng Yang; Min Wang; Andrew McMinn; Xiu‐Lan Chen; Yin Chen; et al. (Environmental Microbiology, 2021)
Summary Most marine copiotrophic bacteria can produce extracellular enzymes to degrade biopolymers into bio‐available smaller solutes, while oligotrophic bacteria usually cannot. Bacterial extracellular enzymes and enzymatic products can be a common resource that could be utilized by both copiotrophs and oligotrophs; when present, oligotrophs may outcompete the enzyme‐producing copiotrophs. However, copiotrophs and oligotrophs consistently coexist in the ocean. How they maintain coexistence has still not been experimentally studied. In this study, the interaction and coexistence of a copiotroph and an oligotroph, isolated from the same surface seawater sample and utilizing the same proteinaceous substrate, were experimentally investigated. The copiotroph could secrete extracellular proteases to degrade and then utilize the proteinaceous substrate. The oligotroph was unable to utilize the proteinaceous substrate by itself, but could grow by using the hydrolysate amino acids. The copiotroph outcompeted the oligotroph by adsorbing the amino acids quickly and having a higher growth rate in the rich medium. The oligotroph survived by adapting to low concentration of nutrients. The copiotroph and oligotroph were able to maintain long‐term (up to 142 days) coexistence in the laboratory. This study indicates that differences in the utilization of different concentrations of nutrients can drive the coexistence of marine copiotrophs and oligotrophs.

Application of solid-phase extraction based on magnetic nanoparticle adsorbents for the analysis of selected persistent organic pollutants in environmental water: A review of recent advances - Aiming Wu; Xiaoli Zhao; Junyu Wang; Zhi Tang; Tianhui Zhao; Lin Niu; Wenqiang Yu; Chunyan Yang; Mengyuan Fang; Hongzhou Lv; Shasha Liu; Fengchang Wu (Critical Reviews in Environmental Science and Technology, 2021)

Identification through fine mapping and verification using CRISPR/Cas9-targeted mutagenesis for a minor QTL controlling grain weight in rice - Aye Nyein Chan; Lin-Lin Wang; Yu-Jun Zhu; Ye-Yang Fan; Jie-Yun Zhuang; Zhen-Hua Zhang (Theoretical and Applied Genetics, 2021)
Key message A minor QTL for grain weight in rice, qTGW1.2b , was fine-mapped. Its casual gene OsVQ4 was confirmed through CRISPR/Cas9-targeted mutagenesis, exhibiting an effect that was larger than the original QTL effect. Abstract The CRISPR/Cas system exhibits a great potential for rice improvement, but the application was severely hindered due to insufficient target genes, especial the lack of validated genes underlying quantitative trait loci having small effects. In this study, a minor QTL for grain weight, qTGW1.2b , was fine-mapped into a 44.0 kb region using seven sets of near isogenic lines (NILs) developed from the indica rice cross (Zhenshan 97) 3 /Milyang 46, followed by validation of the causal gene using CRISPR/Cas9-targeted mutagenesis. In the NIL populations, 1000-grain weight of the Zhenshan 97 homozygous lines decreased by 0.9–2.0% compared with the Milyang 46 homozygous lines. A gene encoding VQ-motif protein, OsVQ4 , was identified as the candidate gene based on parental sequence differences. The effect of OsVQ4 was confirmed by creating CRISPR/Cas9 knockout lines, whose 1000-grain weight decreased by 2.8–9.8% compared with the wild-type transgenic line and the recipient. These results indicate that applying genome editing system could create novel alleles with large phenotypic variation at minor QTLs, which is an effective way to validate causal genes of minor QTLs. Our study establishes a strategy for cloning minor QTLs, which could also be used to identify a large number of potential target genes for the application of CRISPR/Cas system.

Three pleiotropic loci associated with bone mineral density and lean body mass - Yu-Xue Zhang; Shan-Shan Zhang; Shu Ran; Yu Liu; Hong Zhang; Xiao-Lin Yang; Rong Hai; Hui Shen; Qing Tian; Hong-Wen Deng; Lei Zhang; Yu-Fang Pei (Molecular Genetics and Genomics, 2021)

Improving the observation and prediction capabilities for Arctic marine environment: from the perspective of Arctic Shipping - Hui Wang; Qizhen Sun; Lin Zhang; Xi Liang; Qinghua Yang; Na Liu; Chunhua Li; Qingsheng Liu; Bingrui Li; Qian Feng; Xiao Cheng; Yi Yu (Acta Oceanologica Sinica, 2021)

A review of the Chinese monotypic genus Melliodendron (Styracaceae), with a new synonym of M. xylocarpum - Xue-Hui Wu; Rui Zhang; Timothy M. A. Utteridge; Yu-Lin Liu; Guang-Yao Yang; Ming Tang (Kew Bulletin, 2020)

Culturally Tailored Intervention to Promote Mammography Screening Practice Among Chinese American Women: a Systematic Review - Xuehui Zhang; Ping Li; Pingping Guo; Jie Wang; Na Liu; Shu Yang; Lin Yu; Xiumin Zhang; Wei Zhang (Journal of Cancer Education, 2020)

Identification of progranulin as a novel diagnostic biomarker for early-onset sepsis in neonates - Kai-Di Yang; Yu He; Sa Xiao; Qing Ai; Jia-Lin Yu (European Journal of Clinical Microbiology & Infectious Diseases, 2020)

2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales - Jens H. Kuhn; Scott Adkins; Daniela Alioto; Sergey V. Alkhovsky; Gaya K. Amarasinghe; Simon J. Anthony; Tatjana Avšič-Županc; María A. Ayllón; Justin Bahl; Anne Balkema-Buschmann; Matthew J. Ballinger; Tomáš Bartonička; et al. (Archives of Virology, 2020)

Divergence in flowering time is a major component contributing to reproductive isolation between two wild rice species (Oryza rufipogon and O. nivara) - Xun Xu; Qing-Lin Meng; Mu-Fan Geng; Ning-Ning Ren; Lian Zhou; Yu-Su Du; Zhe Cai; Mei-Xia Wang; Xin Wang; Xiu-Hua Wang; Jing-Dan Han; Shuai Jiang; et al. (Science China Life Sciences, 2020)

WDR5a functions in cadmium-inhibited root meristem growth by regulating nitric oxide accumulation in Arabidopsis - Yu Zhang; Yang-Yang Tian; Lin-Feng Wang; Yun-Hui Li; Ting-Ting Li; Wen-Cheng Liu (Planta, 2020)

Illumina sequencing revealed roles of microRNAs in different aluminum tolerance of two citrus species - Yang-Fei Zhou; Yan-Yu Wang; Wei-Wei Chen; Li-Song Chen; Lin-Tong Yang (Physiology and Molecular Biology of Plants, 2020)

Mechanism of contractile dysfunction induced by serotonin in coronary artery in spontaneously hypertensive rats - Hao Wang; Xiao-Yan Gao; Fang Rao; Hui Yang; Zhao-Yu Wang; Lin Liu; Su-Juan Kuang; Qi Wu; Chun-Yu Deng; Jing-Song Xu (Naunyn-Schmiedeberg's Archives of Pharmacology, 2020)

Optimizing the MIC breakpoints of amoxicillin and tetracycline for antibiotic selection in the rescue therapy of H. pylori with bismuth quadruple regimen - Ming-Tsung Hsieh; Wei-Lun Chang; Chung-Tai Wu; Hsiao-Bai Yang; Hsin-Yu Kuo; Meng-Ying Lin; Hsiu-Chi Cheng; Yu-Chin Tsai; Bor-Shyang Sheu (European Journal of Clinical Pharmacology, 2020)

Assimilation of exogenous cyanide cross talk in Oryza sativa L. to the key nodes in nitrogen metabolism - Cheng-Zhi Li; Li Yang; Yu-Juan Lin; Hua Zhang; Saeed Rad; Xiao-Zhang Yu (Ecotoxicology, 2020)

One new sterpurane sesquiterpene from cultures of the basidiomycete Pholiota nameko - Wan-Rong Niu; Cong-Liang Guo; Deng-Ji Lou; Rui-Ting Li; Qiao Xiang; Yu-Lin Zou; Xiu-Ming Cui; Xiao-Yan Yang (Natural Product Research, 2020)

Infusion of Human Mesenchymal Stem Cells Improves Regenerative Niche in Thioacetamide-Injured Mouse Liver - Ying-Hsien Kao; Yu-Chun Lin; Po-Huang Lee; Chia-Wei Lin; Po-Han Chen; Tzong-Shyuan Tai; Yo-Chen Chang; Ming-Huei Chou; Chih-Yang Chang; Cheuk-Kwan Sun (Tissue Engineering and Regenerative Medicine, 2020)

Matriptase and prostasin proteolytic activities are differentially regulated in normal and wounded skin - Shun-Cheng Chang; Chien-Ping Chiang; Chih-Hsin Lai; Po-Wen A. Du; Yu-Sin Hung; Yu-Hsuan Chen; Hui-Yu Yang; Hao-Yu Fang; Shiao-Pieng Lee; Hung-Jen Tang; Jehng-Kang Wang; Michael D. Johnson; et al. (Human Cell, 2020)

Grape seed proanthocyanidin extract ameliorates hepatic lipid accumulation and inflammation in grass carp (Ctenopharyngodon idella) - Rong-Hua Lu; Chao-Bin Qin; Feng Yang; Wen-Ya Zhang; Yu-Ru Zhang; Guo-Kun Yang; Li-Ping Yang; Xiao-Lin Meng; Xiao Yan; Guo-Xing Nie (Fish Physiology and Biochemistry, 2020)

Feasibility of using bed filters packed with rice-straw-based activated carbon and selected biomass waste for the control of frying fume exhaust - Yen-Chi Chen; Xuan-En Yang; Kun-Yi Lin; Wei-Wen Huang; Chi-Chi Lin; Kuo-Pin Yu (Environmental Science and Pollution Research, 2020)

Small RNA profiling reveal regulation of microRNAs in field peanut pod rot pathogen infection - Mian Wang; Chao-xin Zhang; Li-juan Pan; Tong Wang; Na Chen; Ming-na Chen; Zhen Yang; Xin-gang Guo; Shan-lin Yu; Xiao-yuan Chi (Biologia, 2020)

Eddy-resolving Simulation of CAS-LICOM3 for Phase 2 of the Ocean Model Intercomparison Project - Yiwen Li; Hailong Liu; Mengrong Ding; Pengfei Lin; Zipeng Yu; Yongqiang Yu; Yao Meng; Yunlong Li; Xiaodong Jian; Jinrong Jiang; Kangjun Chen; Qian Yang; et al. (Advances in Atmospheric Sciences, 2020)
A 61-year (1958–2018) global eddy-resolving dataset for phase 2 of the Ocean Model Intercomparison Project has been produced by the version 3 of Chinese Academy of Science, the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics/Institute of Atmospheric Physics (LASG/IAP) Climate system Ocean Model (CAS-LICOM3). The monthly and a part of the surface daily data in this study can be accessed on the Earth System Grid Federation (ESGF) node. Besides the details of the model and experiments, the evolutions and spatial patterns of large-scale and mesoscale features are also presented. The mesoscale features are reproduced well in the high-resolution simulation, as the mesoscale activities can contribute up to 50% of the total SST variability in eddy-rich regions. Also, the large-scale circulations are remarkably improved compared with the low-resolution simulation, such as the climatological annual mean SST (the RMSE is reduced from 0.59°C to 0.47°C, globally) and the evolution of Atlantic Meridional Overturning Circulation. The preliminary evaluation also indicates that there are systematic biases in the salinity, the separation location of the western boundary currents, and the magnitude of eddy kinetic energy. All these biases are worthy of further investigation.

FGOALS-g3 Model Datasets for CMIP6 Flux-Anomaly-Forced Model Intercomparison Project - Yaqi Wang; Zipeng Yu; Pengfei Lin; Hailong Liu; Jiangbo Jin; Lijuan Li; Yanli Tang; Li Dong; Kangjun Chen; Yiwen Li; Qian Yang; Mengrong Ding; et al. (Advances in Atmospheric Sciences, 2020)
The Flux-Anomaly-Forced Model Intercomparison Project (FAFMIP) is an endorsed Model Intercomparison Project in phase 6 of the Coupled Model Intercomparison Project (CMIP6). The goal of FAFMIP is to investigate the spread in the atmosphere-ocean general circulation model projections of ocean climate change forced by increased CO 2 , including the uncertainties in the simulations of ocean heat uptake, global mean sea level rise due to ocean thermal expansion and dynamic sea level change due to ocean circulation and density changes. The FAFMIP experiments have already been conducted with the Flexible Global Ocean-Atmosphere-Land System Model, gridpoint version 3.0 (FGOALS-g3). The model datasets have been submitted to the Earth System Grid Federation (ESGF) node. Here, the details of the experiments, the output variables and some baseline results are presented. Compared with the preliminary results of other models, the evolutions of global mean variables can be reproduced well by FGOALS-g3. The simulations of spatial patterns are also consistent with those of other models in most regions except the North Atlantic and the Southern Ocean, indicating large uncertainties in the regional sea level projections of these two regions.

Tyrosine Hydroxylase Gene Polymorphisms Contribute to Opioid Dependence and Addiction by Affecting Promoter Region Function - Jun-lin Liu; Shao-qing Li; Feng Zhu; Yu-xiang Zhang; Ya-nan Wu; Jing-si Yang; Bao Zhang; Chun-xia Yan (NeuroMolecular Medicine, 2020)

Identification and validation of stable quantitative trait loci for grain filling rate in common wheat (Triticum aestivum L.) - Yu Lin; Xiaojun Jiang; Yang Tao; Xilan Yang; Zhiqiang Wang; Fangkun Wu; Shihang Liu; Caixia Li; Mei Deng; Jian Ma; Guangdeng Chen; Yuming Wei; et al. (Theoretical and Applied Genetics, 2020)

Nitrogen and phosphorus co-starvation inhibits anthocyanin synthesis in the callus of grape berry skin - Hui-Zhen Zheng; Huan Wei; Shui-Huan Guo; Xin Yang; Ming-Xin Feng; Xu-Qiao Jin; Yu-Lin Fang; Zhen-Wen Zhang; Teng-Fei Xu; Jiang-Fei Meng (Plant Cell, Tissue and Organ Culture (PCTOC), 2020)

Interferon-α2b spray inhalation did not shorten virus shedding time of SARS-CoV-2 in hospitalized patients: a preliminary matched case-control study - Shao-rui Hao; Ren Yan; Shan-yan Zhang; Jiang-shan Lian; Huan Cai; Xiao-li Zhang; Lin Zheng; Hong-yu Jia; Jian-hua Hu; Guo-dong Yu; Jue-qing Gu; Chan-yuan Ye; et al. (Journal of Zhejiang University-SCIENCE B, 2020)

Synergistic effects of pazopanib and hyperthermia against uterine leiomyosarcoma growth mediated by downregulation of histone acetyltransferase 1 - Chiao-Yun Lin; Angel Chao; Ren-Chin Wu; Li-Yu Lee; Shir-Hwa Ueng; Chia-Lung Tsai; Yun-Shien Lee; Meng-Ting Peng; Lan-Yan Yang; Huei-Jean Huang; Hsin-Shih Wang; Chyong-Huey Lai (Journal of Molecular Medicine, 2020)

Two novel pleiotropic loci associated with osteoporosis and abdominal obesity - Lu Liu; Xiao-Lin Yang; Hong Zhang; Zi-Jia Zhang; Xin-Tong Wei; Gui-Juan Feng; Ju Liu; Hui-Ping Peng; Rong Hai; Hui Shen; Qing Tian; Hong-Wen Deng; et al. (Human Genetics, 2020)

Long-term influence of maize stover and its derived biochar on soil structure and organo-mineral complexes in Northeast China - Qiang Sun; Jun Meng; Binoy Sarkar; Yu Lan; Li Lin; Haifeng Li; Xu Yang; Tiexin Yang; Wenfu Chen; Hailong Wang (Environmental Science and Pollution Research, 2020)

Reconnaissance and learning after the February 6, 2018, earthquake in Hualien, Taiwan - Jui-Liang Lin; Chun-Hsiang Kuo; Yu-Wen Chang; Shu-Hsien Chao; Yi-An Li; Wen-Cheng Shen; Chung-Han Yu; Cho-Yen Yang; Fan-Ru Lin; Hsiao-Hui Hung; Chun-Chung Chen; Chin-Kuo Su; et al. (Bulletin of Earthquake Engineering, 2020)

Comprehensive Investigation and Assessment of Nutrient and Heavy Metal Contamination in the Surface Water of Coastal Bohai Sea in China - Heshan Lin; Hongjun Li; Xiaolong Yang; Zizhou Xu; Yindong Tong; Xingguang Yu (Journal of Ocean University of China, 2020)

Acanthophoraine A, a new pyrrolidine alkaloid from the red alga Acanthophora spicifera - Jia-Li Lin; Yong-Qian Liang; Xiao-Jian Liao; Jian-Ting Yang; Dai-Chun Li; Yu-Ling Huang; Zhi-Hui Jiang; Shi-Hai Xu; Bing-Xin Zhao (Natural Product Research, 2020)

Whole brain radiotherapy induces cognitive dysfunction in mice: key role of gut microbiota - Xiao-Xiao Luo; Chun Yang; Gao-Feng Zhan; Shan Li; Dong-Yu Hua; Ai-Lin Luo; Xiang-Lin Yuan (Psychopharmacology, 2020)

Drought-tolerant plant growth-promoting rhizobacteria isolated from jujube (Ziziphus jujuba) and their potential to enhance drought tolerance - Min Zhang; Lin Yang; Ruqian Hao; Xiaoxiong Bai; Ying Wang; Xuan Yu (Plant and Soil, 2020)

Astrocytic GABAB Receptors in Mouse Hippocampus Control Responses to Behavioral Challenges through Astrocytic BDNF - Ji-Hong Liu; Ze-Lin Li; Yi-Si Liu; Huai-De Chu; Neng-Yuan Hu; Ding-Yu Wu; Lang Huang; Shu-Ji Li; Xiao-Wen Li; Jian-Ming Yang; Tian-Ming Gao (Neuroscience Bulletin, 2020)

Household airborne endotoxin associated with asthma and allergy in elementary school-age children: a case–control study in Kaohsiung, Taiwan - Yu-Chuan Yen; Chun-Yuh Yang; Tsu-Nai Wang; Pei-Chun Yen; Chi-Kung Ho; Kristina D. Mena; Tzu-Chi Lee; Kang-Shin Chen; Yuan-Chung Lin; Pei-Shih Chen (Environmental Science and Pollution Research, 2020)
To evaluate the association between the presence of asthma and allergy, and airborne endotoxin in homes of school-age children in Kaohsiung City, Taiwan, with a case–control study design by matching the age and class exposure. Data collection of home visits included an interviewer-administered questionnaire and air sampling of participants’ homes for endotoxin, bacteria, and fungi, as well as temperature and relative humidity measurements. Endotoxin was detected in all air samples with a median value of 0.67 EU m −3 . In the adjusted logistic regression model, household airborne endotoxin was associated with higher prevalence of asthma and allergy; OR = 4.88 (95% CI 1.16–20.55) for Q3 (between 0.67 and 1.97 EU m −3 ) vs. Q1 (< 0.31 EU m −3 ), with statistical significance. Airborne fungi were associated with higher prevalence of asthma and allergy; OR = 4.47 (95% CI 1.13–17.69) for Q3 (between 314 and 699 CFU m −3 ) vs. Q1 (< 159 CFU m −3 ) in adjusted logistic regression models. Airborne endotoxin and fungi were significantly associated with children’s asthma and allergy.

Erratum to: LICOM Model Datasets for the CMIP6 Ocean Model Intercomparison Project - Pengfei Lin; Zipeng Yu; Hailong Liu; Yongqiang Yu; Yiwen Li; Jinrong Jiang; Wei Xue; Kangjun Chen; Qian Yang; Bowen Zhao; Jilin Wei; Mengrong Ding; et al. (Advances in Atmospheric Sciences, 2020)

Detection of serum IgM and IgG for COVID-19 diagnosis - Ling Zhong; Junlan Chuan; Bo Gong; Ping Shuai; Yu Zhou; Yi Zhang; Zhilin Jiang; Dingding Zhang; Xiaoqi Liu; Shi Ma; Yi Huang; He Lin; et al. (Science China Life Sciences, 2020)

Comparison of epidemiological and clinical characteristics of COVID-19 patients with and without Wuhan exposure - Jiang-shan Lian; Huan Cai; Shao-rui Hao; Xi Jin; Xiao-li Zhang; Lin Zheng; Hong-yu Jia; Jian-hua Hu; Shan-yan Zhang; Guo-dong Yu; Jue-qing Gu; Chan-yuan Ye; et al. (Journal of Zhejiang University-SCIENCE B, 2020)

An overview of COVID-19 - Yu Shi; Gang Wang; Xiao-peng Cai; Jing-wen Deng; Lin Zheng; Hai-hong Zhu; Min Zheng; Bo Yang; Zhi Chen (Journal of Zhejiang University-SCIENCE B, 2020)

First report of Fusarium oxysporum f. sp. canariensis causing Fusarium wilt on Canary Island date palm (Phoenix canariensis Hort. Ex Chabaud) in China - Cheng Zhong Lan; Yu Li Dai; Lin Gan; Jin Ai Yao; Xiu Juan Yang (Journal of Plant Pathology, 2020)

Magnetic properties indicate the sources of hadal sediments in the Yap Trench, northwest Pacific Ocean - Yu Chen; Jichao Yang; Olusegun A. Dada; Yaomin Yang; Zhen Lin; Zhen Cui; Yue Xu; Hongjun Yu; Baohua Liu (Journal of Oceanology and Limnology, 2020)

Assessment of ammonium fertilization as a stimulus for proline accumulation in Oryza sativa L. during cyanide assimilation - W. Liu; X.-Z. Yu; S.-Y. Lei; L. Yang; Y.-J. Lin (International Journal of Environmental Science and Technology, 2020)

Multiple genetic factors affecting the pharmacokinetic and pharmacodynamic processes of tacrolimus in Chinese myasthenia gravis patients - Huan-Yu Meng; Xi Li; Wan-Lin Jin; Cheng-Kai Yan; Xiao-Hua Dong; Qiu Xu; Yu-Yao Peng; Zhi-Bin Li; Yi Li; Zhao-Hui Luo; Li-Qun Xu; Huan Yang (European Journal of Clinical Pharmacology, 2020)

Epitranscriptomic technologies and analyses - Xiaoyu Li; Qiao-Xia Liang; Jin-Ran Lin; Jinying Peng; Jian-Hua Yang; Chengqi Yi; Yang Yu; Qiangfeng Cliff Zhang; Ke-Ren Zhou (Science China Life Sciences, 2020)

The Potential Role of PKA/CREB Signaling Pathway Concerned with Gastrodin Administration on Methamphetamine-Induced Conditioned Place Preference Rats and SH-SY5Y Cell Line - Gen-Meng Yang; Lu Li; Feng-Lin Xue; Chen-Li Ma; Xiao-Feng Zeng; Yong-Na Zhao; Dong-Xian Zhang; Yang Yu; Qian-Wen Yan; Yi-Qing Zhou; Shi-Jun Hong; Li-Hua Li (Neurotoxicity Research, 2020)

Correction to: Development of recombinase polymerase amplification assay for rapid detection of Meloidogyne incognita, M. javanica, M. arenaria, and M. enterolobii - Yuliang Ju; Yu Lin; Guogen Yang; Huiping Wu; Yuemin Pan (European Journal of Plant Pathology, 2020)

Assessing dietary exposure risk to neonicotinoid residues among preschool children in regions of Taiwan - Min-Pei Ling; Huai-An Hsiao; Szu-Chieh Chen; Wei-Yu Chen; Wei-Chun Chou; Yi-Jun Lin; Shu-Han You; Ying-Fei Yang; Hsing-Chieh Lin; Chi-Yun Chen; Tien-Hsuan Lu; Chung-Min Liao (Environmental Science and Pollution Research, 2020)

Impacts of elevated temperature and pCO2 on the brooded larvae of Pocillopora damicornis from Luhuitou Reef, China: evidence for local acclimatization - Lei Jiang; Ming-Lan Guo; Fang Zhang; Yu-Yang Zhang; Guo-Wei Zhou; Xin-Ming Lei; Xiang-Cheng Yuan; You-Fang Sun; Tao Yuan; Lin Cai; Jian-Sheng Lian; Sheng Liu; et al. (Coral Reefs, 2020)

Swelling characteristics of andesite foundation induced by water immersion and their influence on ballastless track subgrade - Jun-yi Duan; Guo-lin Yang; Min Hu; Xiao-qin Lei; Yu-liang Lin (Journal of Mountain Science, 2020)

Hostaflavanol A, a new anti-inflammatory and antioxidant activities flavanol from the flowers of Hosta plantaginea - Li Yang; Yi-min Lin; Zhong-wei He; Ting-fang Zhang; Yu Li; Xiao-tong Xie; Yi-feng Wu; Jun-wei He (Medicinal Chemistry Research, 2020)

Screening for proteins interacting with the perilipin-like protein CAP20 by a yeast two-hybrid system and identification of a protein kinase a catalytic subunit as an interacting protein in Colletotrichum siamense - Jiyuan Wang; Xiaoyu Zhao; Xiaomiao Liao; Qiguang He; Xiao Li; Wenbo Liu; Ziping Yang; Yu Zhang; Chunhua Lin; Weiguo Miao (European Journal of Plant Pathology, 2020)

A stochastic multi-objective optimization decision model for energy facility allocation: a case of liquefied petroleum gas station - Ming-Der Yang; Yi-Ping Chen; Chien-Tsung Wang; Ming-Jay Deng; Yu-Hao Lin; Ho-Wen Chen (Clean Technologies and Environmental Policy, 2020)

LICOM Model Datasets for the CMIP6 Ocean Model Intercomparison Project - Pengfei Lin; Zhipeng Yu; Hailong Liu; Yongqiang Yu; Yiwen Li; Jirong Jiang; Wei Xue; Kangjun Chen; Qian Yang; Bowen Zhao; Jilin Wei; Mengrong Ding; et al. (Advances in Atmospheric Sciences, 2020)
The datasets of two Ocean Model Intercomparison Project (OMIP) simulation experiments from the LASG/IAP Climate Ocean Model, version 3 (LICOM3), forced by two different sets of atmospheric surface data, are described in this paper. The experiment forced by CORE-II (Co-ordinated Ocean–Ice Reference Experiments, Phase II) data (1948–2009) is called OMIP1, and that forced by JRA55-do (surface dataset for driving ocean–sea-ice models based on Japanese 55-year atmospheric reanalysis) data (1958–2018) is called OMIP2. First, the improvement of LICOM from CMIP5 to CMIP6 and the configurations of the two experiments are described. Second, the basic performances of the two experiments are validated using the climatological-mean and interannual time scales from observation. We find that the mean states, interannual variabilities, and long-term linear trends can be reproduced well by the two experiments. The differences between the two datasets are also discussed. Finally, the usage of these data is described. These datasets are helpful toward understanding the origin system bias of the fully coupled model.

Anti- β -amyloid aggregation activity of enantiomeric furolactone-type lignans from Archidendron clypearia (Jack) I.C.N. - Yu-Xi Wang; Bin Lin; Le Zhou; Zhi-Yang Yan; Han Zhang; Xiao-Xiao Huang; Shao-Jiang Song (Natural Product Research, 2020)

Erratum to: Exosome-derived galectin-9 may be a novel predictor of rejection and prognosis after liver transplantation - Ai-bin Zhang; Yi-fan Peng; Jun-jun Jia; Yu Nie; Shi-yu Zhang; Hai-yang Xie; Lin Zhou; Shu-sen Zheng (Journal of Zhejiang University-SCIENCE B, 2020)

Non-motor Symptoms in Parkinson’s Disease Patients with Parkin Mutations: More Depression and Less Executive Dysfunction - Jie Song; Bo Shen; Yu-Jie Yang; Feng-tao Liu; Jue Zhao; Yi-Lin Tang; Chen Chen; Zheng-Tong Ding; Yu An; Jian-Jun Wu; Yi-Min Sun; Jian Wang (Journal of Molecular Neuroscience, 2020)

Assessment of iron-modified calcite/zeolite mixture as a capping material to control sedimentary phosphorus and nitrogen liberation - Yanhui Zhan; Yang Yu; Jianwei Lin; Xiaolong Wu; Yan Wang; Yuying Zhao (Environmental Science and Pollution Research, 2020)

Characterizing the spatial distribution of typical natural disaster vulnerability in China from 2010 to 2017 - Qian Wang; Qi-peng Zhang; Yang-yang Liu; Lin-jing Tong; Yan-zhen Zhang; Xiao-yu Li; Jian-long Li (Natural Hazards, 2020)

Soil particle-size distribution and aggregate stability of new reconstructed purple soil affected by soil erosion in overland flow - Feng-Lin Zuo; Xiao-Yan Li; Xiao-Fan Yang; Yang Wang; Yu-Jun Ma; Yu-Han Huang; Chao-Fu Wei (Journal of Soils and Sediments, 2020)

Biogeochemical responses of soil ecosystems to raw coal pollution in Xuanhua, China - Yu Liu; Wu Xiang; Jie Zhu; Xiu-Zhi Zhang; Xu-Dong Xing; Wei-Lin Yang (Journal of Soils and Sediments, 2020)

Mechanistic examination of methimazole-induced hepatotoxicity in patients with Grave’s disease: a metabolomic approach - Xuesong Li; Jialin Yang; Shasha Jin; Yu Dai; Yujuan Fan; Xiaofang Fan; Zhigang Li; Jianhua Yang; Wai-Ping Yau; Haishu Lin; Weimin Cai; Xiaoqiang Xiang (Archives of Toxicology, 2020)

De Novo and Inherited SETD1A Variants in Early-onset Epilepsy - Xiuya Yu; Lin Yang; Jin Li; Wanxing Li; Dongzhi Li; Ran Wang; Kai Wu; Wenhao Chen; Yi Zhang; Zilong Qiu; Wenhao Zhou (Neuroscience Bulletin, 2019)

Characteristics and Prognosis of Talaromyces marneffei Infection in Non-HIV-Infected Children in Southern China - Jing Guo; Bing-Kun Li; Tian-Min Li; Fang-Lin Wei; Yu-Jiao Fu; Yan-Qing Zheng; Kai-Su Pan; Chun-Yang Huang; Cun-Wei Cao (Mycopathologia, 2019)

Metabolomic profiling on rat brain of prenatal malnutrition: implicated for oxidative stress and schizophrenia - Fei Xu; Xin Li; Weibo Niu; Gaini Ma; Qianqian Sun; Yan Bi; Zhenming Guo; Decheng Ren; Jiaxin Hu; Fan Yuan; Ruixue Yuan; Lei Shi; et al. (Metabolic Brain Disease, 2019)

Mutational signatures and mutagenic impacts associated with betel quid chewing in oral squamous cell carcinoma - Shih-Chi Su; Lun-Ching Chang; Chiao-Wen Lin; Mu-Kuan Chen; Chun-Ping Yu; Wen-Hung Chung; Shun-Fa Yang (Human Genetics, 2019)

Development of recombinase polymerase amplification assay for rapid detection of Meloidogyne incognita, M. javanica, M. arenaria, and M. enterolobii - Yuliang Ju; Yu Lin; Guogen Yang; Huiping Wu; Yuemin Pan (European Journal of Plant Pathology, 2019)

Pathological and therapeutic aspects of matrix metalloproteinases: implications in childhood leukemia - Yi-Hsuan Hsiao; Shih-Chi Su; Chiao-Wen Lin; Yu-Hua Chao; Wei-En Yang; Shun-Fa Yang (Cancer and Metastasis Reviews, 2019)

Protective role of curcumin in cadmium-induced testicular injury in mice by attenuating oxidative stress via Nrf2/ARE pathway - Shu-Hua Yang; Jian-Bin He; Li-Hui Yu; Lin Li; Miao Long; Ming-Da Liu; Peng Li (Environmental Science and Pollution Research, 2019)

Two-factor ANOVA of SSH and RNA-seq analysis reveal development-associated Pi-starvation genes in oilseed rape - Zhong-Wei Zhang; Ling-Yang Feng; Jian-Hui Wang; Yu-Fan Fu; Xin Cai; Chang-Quan Wang; Jun-Bo Du; Ming Yuan; Yang-Er Chen; Pei-Zhou Xu; Ting Lan; Guang-Deng Chen; et al. (Planta, 2019)

Development of Multi-axis Motor Control Systems for Lower Limb Robotic Exoskeleton - Cheng-Tang Pan; Chun-Chieh Chang; Pei-Yuan Sun; Cheng-Lung Lee; Tzu-Chieh Lin; Chung-Kun Yen; Yu-Sheng Yang (Journal of Medical and Biological Engineering, 2019)

Isolation of a New PAK1 Gene from Sea Cucumber (Apostichopus japonicus) and Its Expression Analysis and Function Characterization - Liyuan Ren; Kaiquan Li; Yaoyao Zhan; Yi Wang; Yao Yu; Yang Chen; Kai Lin; Jian Song; Yaqing Chang (Journal of Ocean University of China, 2019)

Effects of drought–re-watering–drought on the photosynthesis physiology and secondary metabolite production of Bupleurum chinense DC. - Linlin Yang; Yu Zhao; Qi Zhang; Lin Cheng; Mei Han; Yueying Ren; Limin Yang (Plant Cell Reports, 2019)

Comprehensive transcriptomics and proteomics analyses of rice stripe virus-resistant transgenic rice - Yang Xu; Lvjie Bi; Zipeng Yu; Chao Lin; Liming Gan; Lifei Zhu; Haiyang Li; Yunzhi Song; Changxiang Zhu (Journal of Biosciences, 2019)

Crystal structure of norsethite-type BaMn(CO3)2 and its pressure-induced transition investigated by Raman spectroscopy - Wen Liang; Lin Li; Yuan Yin; Rui Li; Zeming Li; Xiqiang Liu; Chaoshuai Zhao; Shuguang Yang; Yong Meng; Zengsheng Li; Yu He; Heping Li (Physics and Chemistry of Minerals, 2019)

Seasonal Dynamics of Gastrointestinal Nematode Infections of Goats and Emergence of Ivermectin Resistance in Haemonchus contortus in Hubei Province, China - Wei Yuan; Ke Lu; Hao Li; Jinming Liu; Chuanchuan He; Jintao Feng; Xin Zhang; Yudan Mao; Yang Hong; Yu Zhou; Jun Lu; Yamei Jin; et al. (Acta Parasitologica, 2019)

Ocean Climate Monitoring - Rick Cole; Jeff Kinder; Weidong Yu; Chun Lin Ning; Fujun Wang; Yang Chao (Frontiers in Marine Science, 2019)

Four LysR-type transcriptional regulator family proteins (LTTRs) involved in antibiotic resistance in Aeromonas hydrophila - Yuying Fu; Qilan Cai; Yuqian Wang; Wanxin Li; Jing Yu; Guidi Yang; Wenxiong Lin; Xiangmin Lin (World Journal of Microbiology and Biotechnology, 2019)

A breeding strategy targeting the secondary gene pool of bread wheat: introgression from a synthetic hexaploid wheat - Ming Hao; Lianquan Zhang; Laibin Zhao; Shoufen Dai; Aili Li; Wuyun Yang; Die Xie; Qingcheng Li; Shunzong Ning; Zehong Yan; Bihua Wu; Xiujin Lan; et al. (Theoretical and Applied Genetics, 2019)

Pseudoxanthomonas composti sp. nov., isolated from compost - Jun Lin; Guiqin Yang; Jia Tang; Zhen Li; Zhen Yu; Li Zhuang (Antonie van Leeuwenhoek, 2019)

Exosome-derived galectin-9 may be a novel predictor of rejection and prognosis after liver transplantation - Ai-bin Zhang; Yi-fan Peng; Jun-jun Jia; Yu Nie; Shi-yu Zhang; Hai-yang Xie; Lin Zhou; Shu-sen Zheng (Journal of Zhejiang University-SCIENCE B, 2019)

Neural Differentiation of Mouse Neural Stem Cells as a Tool to Assess Developmental Neurotoxicity of Drinking Water in Taihu Lake - Yang Zhou; Yu Fu; Zhendong Bai; Peixin Li; Bo Zhao; Yuehua Han; Ting Xu; Ningyan Zhang; Lin Lin; Jian Cheng; Jun Zhang; Jing Zhang (Biological Trace Element Research, 2019)

Electroacupuncture inhibits visceral pain via adenosine receptors in mice with inflammatory bowel disease - Tengfei Hou; Hongchun Xiang; Lingling Yu; Wen Su; Yang Shu; Hongping Li; He Zhu; Lixue Lin; Xuefei Hu; Shangdong Liang; Hong Zhang; Man Li (Purinergic Signalling, 2019)

Long non-coding RNA and mRNA analysis of Ang II-induced neuronal dysfunction - Lin-Lin Shao; Yue-Hua Jiang; Ling-Yu Jiang; Chuan-Hua Yang; Ying-Zi Qi (Molecular Biology Reports, 2019)

Slope deformation monitoring in the Jiufenershan landslide using time domain reflectometry technology - Shei-Chen Ho; I-Hui Chen; Yu-Shu Lin; Jun-Yang Chen; Miau-Bin Su (Landslides, 2019)