A Novel Oral Preparation of Hydroxysafflor Yellow A Base on a Chitosan Complex: A Strategy to Enhance the Oral Bioavailability - Guan-nan Ma; Fang-lin Yu; Shan Wang; Zhi-ping Li; Xiang-yang Xie; Xing-guo Mei (AAPS PharmSciTech, 2015)

Influence of β-cyclodextrin on the Properties of Norfloxacin Form A - Lucas Chierentin; Claudia Garnero; Ana Karina Chattah; Poonam Delvadia; Thomas Karnes; Marcela Raquel Longhi; Hérida Regina Nunes Salgado (AAPS PharmSciTech, 2015)

Effects of the Preparation Method on the Formation of True Nimodipine SBE-β-CD/HP-β-CD Inclusion Complexes and Their Dissolution Rates Enhancement - Farouk Semcheddine; Nida El Islem Guissi; XueYin Liu; ZuoMin Wu; Bo Wang (AAPS PharmSciTech, 2015)

Topical Lyogel Containing Corticosteroid Decreases IgE Expression and Enhances the Therapeutic Efficacy Against Atopic Eczema - Shiow-Fern Ng; Nurul-Asmaa Anuwi; Tengku-Noraisyah Tengku-Ahmad (AAPS PharmSciTech, 2015)

Controlled Extraction Studies Applied to Polyvinyl Chloride and Polyethylene Materials: Conclusions from the ELSIE Controlled Extraction Pilot Study - Andrew Teasdale; Michael Jahn; Simon Bailey; Andrew Feilden; Graham Taylor; Marta L. Corcoran; Robert Malick; Dennis Jenke; Cheryl L. M. Stults; Lee M. Nagao (AAPS PharmSciTech, 2015)

Pediatric Suppositories of Sulpiride Solid Dispersion for Treatment of Tourette Syndrome: In Vitro and In Vivo Investigations - Ahmed S. Zidan; Sherif E. Emam; Tamer M. Shehata; Fakhr-eldin S. Ghazy (AAPS PharmSciTech, 2015)

Influence of Colloidal Silicon Dioxide on Gel Strength, Robustness, and Adhesive Properties of Diclofenac Gel Formulation for Topical Application - Zheng Lu; Reza Fassihi (AAPS PharmSciTech, 2015)

Preformulation Studies on Solid Self-Emulsifying Systems in Powder Form Containing Magnesium Aluminometasilicate as Porous Carrier - Anna Krupa; Jakub Szlęk; Benedykt R. Jany; Renata Jachowicz (AAPS PharmSciTech, 2015)

An Investigation and Characterization on Alginate Hydogel Dressing Loaded with Metronidazole Prepared by Combined Inotropic Gelation and Freeze-Thawing Cycles for Controlled Release - Omar Sarheed; Bazigha K. Abdul Rasool; Eman Abu-Gharbieh; Uday Sajad Aziz (AAPS PharmSciTech, 2015)

Nanomicellar Topical Aqueous Drop Formulation of Rapamycin for Back-of-the-Eye Delivery - Kishore Cholkar; Sriram Gunda; Ravinder Earla; Dhananjay Pal; Ashim K. Mitra (AAPS PharmSciTech, 2015)

The Influence of Secondary Processing on the Structural Relaxation Dynamics of Fluticasone Propionate - Roberto Depasquale; Sau L. Lee; Bhawana Saluja; Jagdeep Shur; Robert Price (AAPS PharmSciTech, 2015)

Kinetic Modelling for the Assay of Nortriptyline Hydrochloride Using Potassium Permanganate as Oxidant - Nafisur Rahman; Sumaiya Khan (AAPS PharmSciTech, 2015)

Anti-Hepatoma Activity of a Novel Compound Glaucocalyxin H In Vivo and In Vitro - Guangfan Hai; Chong Zhang; Yanlong Jia; Suping Bai; Jinfen Han; Lanqing Guo; Taizhen Cui; Bingxuan Niu; Feng Huang; Yu Song (AAPS PharmSciTech, 2015)

Anti-Obesity Effects of Melastoma malabathricum var Alba Linn in Rats Fed with a High-Fat Diet - Sundram Karupiah; Zhari Ismail (AAPS PharmSciTech, 2015)

Controlled Porosity Solubility Modulated Osmotic Pump Tablets of Gliclazide - Arti Banerjee; P. R. P. Verma; Subhash Gore (AAPS PharmSciTech, 2015)

Simultaneous Determination of Acetaminophen and Synthetic Color(s) by Derivative Spectroscopy in Syrup Formulations and Validation by HPLC: Exposure Risk of Colors to Children - Shanya Das Rastogi; Sumita Dixit; Anurag Tripathi; Mukul Das (AAPS PharmSciTech, 2015)

Development of Modified-Release Tablets of Zolpidem Tartrate by Biphasic Quick/Slow Delivery System - Anjan Kumar Mahapatra; N. H. Sameeraja; P. N. Murthy (AAPS PharmSciTech, 2015)

Potential of Piperazinylalkylester Prodrugs of 6-Methoxy-2-Naphthylacetic Acid (6-MNA) for Percutaneous Drug Delivery - Vijay Pawar; Rushabh Thosani; Ashish Kanhed; Rajani Giridhar; Mange Ram Yadav (AAPS PharmSciTech, 2015)

Characterization and Comparison of Lidocaine-Tetracaine and Lidocaine-Camphor Eutectic Mixtures Based on Their Crystallization and Hydrogen-Bonding Abilities - Urvi Gala; Monica C. Chuong; Ravi Varanasi; Harsh Chauhan (AAPS PharmSciTech, 2015)

Lyophilized Sustained Release Mucoadhesive Chitosan Sponges for Buccal Buspirone Hydrochloride Delivery: Formulation and In Vitro Evaluation - Mohamed A. A. Kassem; Aliaa N. ElMeshad; Ahmed R. Fares (AAPS PharmSciTech, 2015)

Orally Disintegrating Films and Mini-Tablets—Innovative Dosage Forms of Choice for Pediatric Use - Maren Preis (AAPS PharmSciTech, 2015)

Targeting Therapeutics Across the Blood Brain Barrier (BBB), Prerequisite Towards Thrombolytic Therapy for Cerebrovascular Disorders—an Overview and Advancements - K. K. Pulicherla; Mahendra Kumar Verma (AAPS PharmSciTech, 2015)

A Study on the Impact of Hydroxypropyl Methylcellulose on the Viscosity of PEG Melt Suspensions Using Surface Plots and Principal Component Analysis - Ching Mien Oh; Paul Wan Sia Heng; Lai Wah Chan (AAPS PharmSciTech, 2015)

Supercritical CO2 Generation of Nanometric Structure from Ocimum basilicum Mucilage Prepared for Pharmaceutical Applications - Iman Akbari; Seyyed M. Ghoreishi; Neda Habibi (AAPS PharmSciTech, 2015)

Spontaneous Emulsification of Nifedipine-Loaded Self-Nanoemulsifying Drug Delivery System - Yotsanan Weerapol; Sontaya Limmatvapirat; Mont Kumpugdee-Vollrath; Pornsak Sriamornsak (AAPS PharmSciTech, 2015)

Masking the Bitter Taste of Injectable Lidocaine HCl Formulation for Dental Procedures - Yangjie Wei; Michael P. Nedley; Sarit B. Bhaduri; Xavier Bredzinski; Sai H. S. Boddu (AAPS PharmSciTech, 2015)

Influence of Process and Formulation Parameters on Dissolution and Stability Characteristics of Kollidon® VA 64 Hot-Melt Extrudates - Sindhuri Maddineni; Sunil Kumar Battu; Joe Morott; Soumyajit Majumdar; S. N. Murthy; Michael A. Repka (AAPS PharmSciTech, 2015)

Protein-Functionalized PLGA Nanoparticles of Lamotrigine for Neuropathic Pain Management - Jigar Lalani; Sushilkumar Patil; Atul Kolate; Riddhi Lalani; Ambikanandan Misra (AAPS PharmSciTech, 2015)

Impact of Physicochemical Environment on the Super Disintegrant Functionality of Cross-Linked Carboxymethyl Sodium Starch: Insight on Formulation Precautions - Michèle Delalonde; Raja Fitouri; Emilie Ruiz; Bernard Bataille; Tahmer Sharkawi (AAPS PharmSciTech, 2015)

Molecular Interaction Studies of Amorphous Solid Dispersions of the Antimelanoma Agent Betulinic Acid - Meiki Yu; Joseph E. Ocando; Louis Trombetta; Parnali Chatterjee (AAPS PharmSciTech, 2015)

Determining the Polymer Threshold Amount for Achieving Robust Drug Release from HPMC and HPC Matrix Tablets Containing a High-Dose BCS Class I Model Drug: In Vitro and In Vivo Studies - Uroš Klančar; Saša Baumgartner; Igor Legen; Polona Smrdel; Nataša Jeraj Kampuš; Dejan Krajcar; Boštjan Markun; Klemen Kočevar (AAPS PharmSciTech, 2015)

Proniosomal Oral Tablets for Controlled Delivery and Enhanced Pharmacokinetic Properties of Acemetacin - Tamer M. Shehata; Marwa H. Abdallah; Mahmoud Mokhtar Ibrahim (AAPS PharmSciTech, 2015)

Development and Evaluation of Curcumin-loaded Elastic Vesicles as an Effective Topical Anti-inflammatory Formulation - Rumjhum Agrawal; Simarjot Kaur Sandhu; Ikksheta Sharma; Indu Pal Kaur (AAPS PharmSciTech, 2015)

Novel Pentablock Copolymer-Based Nanoparticulate Systems for Sustained Protein Delivery - Sulabh P. Patel; Ravi Vaishya; Dhananjay Pal; Ashim K. Mitra (AAPS PharmSciTech, 2015)

Bilayer Matrix Tablets for Prolonged Actions of Metformin Hydrochloride and Repaglinide - Wei He; Shijing Huang; Chunyan Zhou; Lin Cao; Jing Yao; Jianping Zhou; Guangji Wang; Lifang Yin (AAPS PharmSciTech, 2015)

Surface Acidity and Solid-State Compatibility of Excipients with an Acid-Sensitive API: Case Study of Atorvastatin Calcium - Ramprakash Govindarajan; Margaret Landis; Bruno Hancock; Larry A. Gatlin; Raj Suryanarayanan; Evgenyi Y. Shalaev (AAPS PharmSciTech, 2015)

A Risk-Based Approach to Management of Leachables Utilizing Statistical Analysis of Extractables - Cheryl L. M. Stults; Jaromir Mikl; Oliver Whelehan; Bradley Morrical; William Duffield; Lee M. Nagao (AAPS PharmSciTech, 2015)

Modified Cellulose Nanocrystal for Vitamin C Delivery - Seyedeh Parinaz Akhlaghi; Richard M Berry; Kam Chiu Tam (AAPS PharmSciTech, 2015)

Development and Characterization of Sorbitan Monostearate and Sesame Oil-Based Organogels for Topical Delivery of Antimicrobials - Vinay K. Singh; Krishna Pramanik; Sirsendu S. Ray; Kunal Pal (AAPS PharmSciTech, 2015)

Antitumor Activity of DMAKO-05, a Novel Shikonin Derivative, and Its Metabolism in Rat Liver Microsome - Xu Zhang; Ru-Bing Wang; Wen Zhou; Sui Xiao; Qing-Qing Meng; Shao-Shun Li (AAPS PharmSciTech, 2015)

Comparative Pharmacokinetic Study of Mangiferin After Oral Administration of Pure Mangiferin and US Patented Polyherbal Formulation to Rats - Ananth Kumar Kammalla; Mohan Kumar Ramasamy; Jyothi Inampudi; Govind Prasad Dubey; Aruna Agrawal; Ilango Kaliappan (AAPS PharmSciTech, 2015)

Roller Compaction of Hydrophilic Extended Release Tablets—Combined Effects of Processing Variables and Drug/Matrix Former Particle Size - Johanna Heiman; Farhad Tajarobi; Bindhumadhavan Gururajan; Anne Juppo; Susanna Abrahmsén-Alami (AAPS PharmSciTech, 2015)

Preparation of Polyamide Nanocapsules of Aloe vera L. Delivery with In Vivo Studies - Akbar Esmaeili; Maryam Ebrahimzadeh (AAPS PharmSciTech, 2015)

Biopolymer-Based Transdermal Films of Donepezil as an Alternative Delivery Approach in Alzheimer’s Disease Treatment - Maviye Galipoğlu; Meryem Sedef Erdal; Sevgi Güngör (AAPS PharmSciTech, 2015)

A Novel Approach in Distinguishing Between Role of Hydrodynamics and Mechanical Stresses Similar to Contraction Forces of GI Tract on Drug Release from Modified Release Dosage Forms - Majde Takieddin; Reza Fassihi (AAPS PharmSciTech, 2015)

How Do You Use AAPS PharmSciTech? - Robert O. Williams (AAPS PharmSciTech, 2015)

Translational Application of Nano Delivery Systems: Emerging Cancer Therapy - Mahavir B. Chougule; Chalet Tan (AAPS PharmSciTech, 2015)

Polymeric Micelles for Multi-Drug Delivery in Cancer - Hyunah Cho; Tsz Chung Lai; Keishiro Tomoda; Glen S. Kwon (AAPS PharmSciTech, 2015)

Simulation of In Vitro Dissolution Behavior Using DDDPlus™ - May Almukainzi; Arthur Okumu; Hai Wei; Raimar Löbenberg (AAPS PharmSciTech, 2015)

Quality-by-Design III: Application of Near-Infrared Spectroscopy to Monitor Roller Compaction In-process and Product Quality Attributes of Immediate Release Tablets - Ravikanth Kona; Raafat M. Fahmy; Gregg Claycamp; James E. Polli; Marilyn Martinez; Stephen W. Hoag (AAPS PharmSciTech, 2015)

Factors Influencing Aerodynamic Particle Size Distribution of Suspension Pressurized Metered Dose Inhalers - Poonam Sheth; Stephen W. Stein; Paul B. Myrdal (AAPS PharmSciTech, 2015)

Biopharmaceutics Classification System-Based Biowaivers for Generic Oncology Drug Products: Case Studies - Nilufer Tampal; Haritha Mandula; Hongling Zhang; Bing V. Li; Hoainhon Nguyen; Dale P. Conner (AAPS PharmSciTech, 2015)

Antibacterial Activity and Inhibition of Adherence of Streptococcus mutans by Propolis Electrospun Fibers - Chawalinee Asawahame; Krit Sutjarittangtham; Sukum Eitssayeam; Yingmanee Tragoolpua; Busaban Sirithunyalug; Jakkapan Sirithunyalug (AAPS PharmSciTech, 2015)

Development of a Material Sparing Bulk Density Test Comparable to a Standard USP Method for Use in Early Development of API’s - Helen Hughes; Michael M. Leane; Michael Tobyn; John F. Gamble; Santiago Munoz; Pauline Musembi (AAPS PharmSciTech, 2015)

Formulation, Physicochemical Characterization, and In Vitro Study of Chitosan/HPMC Blends-Based Herbal Blended Patches - Jirapornchai Suksaeree; Chaowalit Monton; Fameera Madaka; Tun Chusut; Worawan Saingam; Wiwat Pichayakorn; Prapaporn Boonme (AAPS PharmSciTech, 2015)

Evaluation of Extractables in Processed and Unprocessed Polymer Materials Used for Pharmaceutical Applications - Cheryl L. M. Stults; Jennifer M. Ansell; Arthur J. Shaw; Lee M. Nagao (AAPS PharmSciTech, 2015)

Injectable Supramolecular Hydrogel from Insulin-Loaded Triblock PCL-PEG-PCL Copolymer and γ-Cyclodextrin with Sustained-Release Property - Elham Khodaverdi; Zinat Heidari; Sayyed A. Sajadi Tabassi; Mohsen Tafaghodi; Mona Alibolandi; Farnaz Sadat Mirzazadeh Tekie; Bahman Khameneh; Farzin Hadizadeh (AAPS PharmSciTech, 2015)

Relationships Between the Properties of Self-Emulsifying Pellets and of the Emulsions Used as Massing Liquids for Their Preparation - Ioannis Nikolakakis; Athanasia Panagopoulou; Andrea Salis; Stavros Malamataris (AAPS PharmSciTech, 2015)

Preparation and Optimization of Resveratrol Nanosuspensions by Antisolvent Precipitation Using Box-Behnken Design - Jifu Hao; Yun Gao; Jing Zhao; Jimei Zhang; Qiankui Li; Zhongxi Zhao; Jiyong Liu (AAPS PharmSciTech, 2015)

Development and Characterization of Mixed Niosomes for Oral Delivery Using Candesartan Cilexetil as a Model Poorly Water-Soluble Drug - Zerrin Sezgin-Bayindir; Mustafa Naim Antep; Nilufer Yuksel (AAPS PharmSciTech, 2015)

Multifunctional Nanoparticles for Prostate Cancer Therapy - Shantanu S. Chandratre; Alekha K. Dash (AAPS PharmSciTech, 2015)

Disintegration Mediated Controlled Release Supersaturating Solid Dispersion Formulation of an Insoluble Drug: Design, Development, Optimization, and In Vitro Evaluation - Sanjay Verma; Varma S. Rudraraju (AAPS PharmSciTech, 2015)

Tyloxapol Niosomes as Prospective Drug Delivery Module for Antiretroviral Drug Nevirapine - S. K. Mehta; Neha Jindal (AAPS PharmSciTech, 2015)

Application of Absorption Modeling to Predict Bioequivalence Outcome of Two Batches of Etoricoxib Tablets - Amitava Mitra; Filippos Kesisoglou; Peter Dogterom (AAPS PharmSciTech, 2015)

Serratiopeptidase Loaded Chitosan Nanoparticles by Polyelectrolyte Complexation: In Vitro and In Vivo Evaluation - Nitin Mali; Preeti Wavikar; Pradeep Vavia (AAPS PharmSciTech, 2015)

Probucol Release from Novel Multicompartmental Microcapsules for the Oral Targeted Delivery in Type 2 Diabetes - Armin Mooranian; Rebecca Negrulj; Hesham S. Al-Sallami; Zhongxiang Fang; Momir Mikov; Svetlana Golocorbin-Kon; Marc Fakhoury; Gerald F. Watts; Vance Matthews; Frank Arfuso; Amanda Lambros; Hani Al-Salami (AAPS PharmSciTech, 2015)

Development and Evaluation of Avanafil Self-nanoemulsifying Drug Delivery System with Rapid Onset of Action and Enhanced Bioavailability - Usama A. Fahmy; Osama A. A. Ahmed; Khaled M. Hosny (AAPS PharmSciTech, 2015)

Model Drug as Pore Former for Controlled Release of Water-Soluble Metoprolol Succinate from Ethylcellulose-Coated Pellets Without Lag Phase: Opportunities and Challenges - Yuli Wang; Jingjing Dai; Xinyi Chang; Meiyan Yang; Ruifang Shen; Li Shan; Yong Qian; Chunsheng Gao (AAPS PharmSciTech, 2015)

Development and Validation of a UPLC Method for Rapid and Simultaneous Analysis of Proton Pump Inhibitors - Richard T. Addo; Kenneth Davis; Ruhi Ubale; Joel S. Owen; E. Blake Watkins (AAPS PharmSciTech, 2015)

The Influence of Ionizing Radiation on Itraconazole in the Solid State - Katarzyna Dettlaff; Przemysław Talik; Grzegorz Spólnik; Witold Danikiewicz; Magdalena Ogrodowczyk (AAPS PharmSciTech, 2015)

Sound Waves Effectively Assist Tobramycin in Elimination of Pseudomonas aeruginosa Biofilms In vitro - H. M. H. N. Bandara; A. Harb; D. Kolacny; P. Martins; H. D. C. Smyth (AAPS PharmSciTech, 2014)

Development and Characterization of siRNA Lipoplexes: Effect of Different Lipids, In Vitro Evaluation in Cancerous Cell Lines and In Vivo Toxicity Study - Nirav Khatri; Dipesh Baradia; Imran Vhora; Mohan Rathi; Ambikanandan Misra (AAPS PharmSciTech, 2014)

Regulatory Considerations for the Classification of Video Monitoring in Dissolution Testing - Kinh Tieu; Alger Salt; James Wirges; Geoffrey N. Grove (AAPS PharmSciTech, 2014)

Effect of Arginine on Pre-nucleus Stage of Interferon Beta-1b Aggregation - Ahmad Fazeli; Mohadeseh Haji-Abdolvahab; Seyed Abbas Shojaosadati; Huub Schellekens; Khosro Khalifeh; Ali Akbar Moosavi-Movahedi; Mohammad Reza Fazeli (AAPS PharmSciTech, 2014)

Pharmaceutical and Pharmacokinetic Evaluation of a Novel Fast Dissolving Film Formulation of Flupentixol Dihydrochloride - Ahmed Abdelbary; Ehab R. Bendas; Afaf A. Ramadan; Dalia A. Mostafa (AAPS PharmSciTech, 2014)

Intranasal Drug Delivery of Olanzapine-Loaded Chitosan Nanoparticles - Sarah Baltzley; Atiquzzaman Mohammad; Ahmad H. Malkawi; Abeer M. Al-Ghananeem (AAPS PharmSciTech, 2014)

Photodegradation of Moxifloxacin in Aqueous and Organic Solvents: A Kinetic Study - Iqbal Ahmad; Raheela Bano; Syed Ghulam Musharraf; Sofia Ahmed; Muhammad Ali Sheraz; Qamar ul Arfeen; Muhammad Salman Bhatti; Zufi Shad (AAPS PharmSciTech, 2014)

High-Performing Dry Powder Inhalers of Paclitaxel DPPC/DPPG Lung Surfactant-Mimic Multifunctional Particles in Lung Cancer: Physicochemical Characterization, In Vitro Aerosol Dispersion, and Cellular Studies - Samantha A. Meenach; Kimberly W. Anderson; J. Zach Hilt; Ronald C. McGarry; Heidi M. Mansour (AAPS PharmSciTech, 2014)

Effect of Backing Films on the Transdermal Delivery of Donepezil from Patches - Nannan Liu; Yaqiong Zhang; Dongmei Cun; Peng Quan; Liang Fang (AAPS PharmSciTech, 2014)

Brain-Targeted Delivery of Docetaxel by Glutathione-Coated Nanoparticles for Brain Cancer - Aditya Grover; Anjali Hirani; Yashwant Pathak; Vijaykumar Sutariya (AAPS PharmSciTech, 2014)

Comparative Study on the Suitability of Two Techniques for Measuring the Transfer of Lipophilic Drug Models from Lipid Nanoparticles to Lipophilic Acceptors - Mohamed Dawoud; Fahima M. Hashem (AAPS PharmSciTech, 2014)

Biologic Comparison of Inhaled Insulin Formulations: ExuberaTM and Novel Spray-Dried Engineered Particles of Dextran-10 - Philip J. Kuehl; Alan Cherrington; Dan E. Dobry; Dale Edgerton; Dwayne T. Friesen; Charles Hobbs; Chet L. Leach; Brice Murri; Doss Neal; David K. Lyon; David T. Vodak; Matthew D. Reed (AAPS PharmSciTech, 2014)

Swellable Ciprofloxacin-Loaded Nano-in-Micro Hydrogel Particles for Local Lung Drug Delivery - Ju Du; Ibrahim M. El-Sherbiny; Hugh D. Smyth (AAPS PharmSciTech, 2014)

Nanomedicine Scale-up Technologies: Feasibilities and Challenges - Rishi Paliwal; R. Jayachandra Babu; Srinath Palakurthi (AAPS PharmSciTech, 2014)

A Method to Evaluate the Effect of Contact with Excipients on the Surface Crystallization of Amorphous Drugs - Si-Wei Zhang; Lian Yu; Jun Huang; Munir A. Hussain; Lotfi Derdour; Feng Qian; Melgardt M. de Villiers (AAPS PharmSciTech, 2014)

Preparation and Characterization of Fenofibrate-Loaded Nanostructured Lipid Carriers for Oral Bioavailability Enhancement - Tuan Hiep Tran; Thiruganesh Ramasamy; Duy Hieu Truong; Han-Gon Choi; Chul Soon Yong; Jong Oh Kim (AAPS PharmSciTech, 2014)

Characterization and Evaluation of 5-Fluorouracil-Loaded Solid Lipid Nanoparticles Prepared via a Temperature-Modulated Solidification Technique - Meghavi N. Patel; Sushant Lakkadwala; Mohamed S. Majrad; Elisha R. Injeti; Steven M. Gollmer; Zahoor A. Shah; Sai Hanuman Sagar Boddu; Jerry Nesamony (AAPS PharmSciTech, 2014)

Novel Orally Swallowable IntelliCap® Device to Quantify Regional Drug Absorption in Human GI Tract Using Diltiazem as Model Drug - Dieter Becker; Jin Zhang; Tycho Heimbach; Robert C. Penland; Christoph Wanke; Jeff Shimizu; Kenneth Kulmatycki (AAPS PharmSciTech, 2014)

Synthesis of a Semi-Interpenetrating Polymer Network as a Bioactive Curcumin Film - Naeema Mayet; Pradeep Kumar; Yahya E. Choonara; Lomas K. Tomar; Charu Tyagi; Lisa C. du Toit; Viness Pillay (AAPS PharmSciTech, 2014)

Liquid Crystalline Systems for Transdermal Delivery of Celecoxib: In Vitro Drug Release and Skin Permeation Studies - Éder André Estracanholli; Fabíola Silva Garcia Praça; Ana Beatriz Cintra; Maria Bernadete Riemma Pierre; Marilisa Guimarães Lara (AAPS PharmSciTech, 2014)

Optimization of Dexamethasone Mixed Nanomicellar Formulation - Kishore Cholkar; Sudharshan Hariharan; Sriram Gunda; Ashim K. Mitra (AAPS PharmSciTech, 2014)

Integrating Artificial and Human Intelligence into Tablet Production Process - Matjaž Gams; Matej Horvat; Matej Ožek; Mitja Luštrek; Anton Gradišek (AAPS PharmSciTech, 2014)

Lateral Drug Diffusion in Human Nails - Biji B. Palliyil; Cong Li; Suzan Owaisat; David B. Lebo (AAPS PharmSciTech, 2014)

An Application of Serially Balanced Designs for the Study of Known Taste Samples with the α-ASTREE Electronic Tongue - S. Altan; M. Francois; S. Inghelbrecht; A. Manola; Y. Shen (AAPS PharmSciTech, 2014)

Evaluation of Granulated Lactose as a Carrier for DPI Formulations 1: Effect of Granule Size - Ping Du; Ju Du; Hugh D. C. Smyth (AAPS PharmSciTech, 2014)

Enzymes in the Dissolution Testing of Gelatin Capsules - Margareth R. C. Marques (AAPS PharmSciTech, 2014)

Glass Delamination: a Comparison of the Inner Surface Performance of Vials and Pre-filled Syringes - Jianxiu Zhao; Virginie Lavalley; Paolo Mangiagalli; Justin M. Wright; Theresa E. Bankston (AAPS PharmSciTech, 2014)

Aerodynamic and Electrostatic Properties of Model Dry Powder Aerosols: a Comprehensive Study of Formulation Factors - M. J. Telko; A. J. Hickey (AAPS PharmSciTech, 2014)

Effectiveness of Spray Congealing to Obtain Physically Stabilized Amorphous Dispersions of a Poorly Soluble Thermosensitive API - Viraj Vitthal Kulthe; Pravin Digambar Chaudhari (AAPS PharmSciTech, 2014)

Impact of Anti-tacking Agents on Properties of Gas-Entrapped Membrane and Effervescent Floating Tablets - Worawut Kriangkrai; Satit Puttipipatkhachorn; Pornsak Sriamornsak; Thaned Pongjanyakul; Srisagul Sungthongjeen (AAPS PharmSciTech, 2014)

Nanoparticle Ligand Presentation for Targeting Solid Tumors - Jason T. Duskey; Kevin G. Rice (AAPS PharmSciTech, 2014)

An Epichlorohydrin-Crosslinked Semi-Interpenetrating GG-PEO Network as a Xerogel Matrix for Sustained Release of Sulpiride - Famida G. Hoosain; Yahya E. Choonara; Pradeep Kumar; Lomas K. Tomar; Charu Tyagi; Lisa C. du Toit; Viness Pillay (AAPS PharmSciTech, 2014)

Preclinical Formulations: Insight, Strategies, and Practical Considerations - Sanket M. Shah; Ankitkumar S. Jain; Ritu Kaushik; Mangal S. Nagarsenker; Maneesh J. Nerurkar (AAPS PharmSciTech, 2014)

Combined Use of Crystalline Sodium Salt and Polymeric Precipitation Inhibitors to Improve Pharmacokinetic Profile of Ibuprofen through Supersaturation - Jenna L. Terebetski; John J. Cummings; Scott E. Fauty; Bozena Michniak-Kohn (AAPS PharmSciTech, 2014)

Effect of Ascorbic Acid on the Degradation of Cyanocobalamin and Hydroxocobalamin in Aqueous Solution: A Kinetic Study - Iqbal Ahmad; Kiran Qadeer; Saima Zahid; Muhammad Ali Sheraz; Tehmina Ismail; Waqar Hussain; Izhar Ahmad Ansari (AAPS PharmSciTech, 2014)

Vancomycin-Eluting Niosomes: A New Approach to the Inhibition of Staphylococcal Biofilm on Abiotic Surfaces - Heba S. Barakat; Mervat A. Kassem; Labiba K. El-Khordagui; Nawal M. Khalafallah (AAPS PharmSciTech, 2014)

The Melanogenesis-Inhibitory Effect and the Percutaneous Formulation of Ginsenoside Rb1 - Lin Wang; Ai-Ping Lu; Zhi-Ling Yu; Ricky N. S. Wong; Zhao-Xiang Bian; Hoi-Hin Kwok; Patrick Ying-Kit Yue; Li-Min Zhou; HuBiao Chen; Min Xu; Zhijun Yang (AAPS PharmSciTech, 2014)

Novel Dexamethasone-Loaded Nanomicelles for the Intermediate and Posterior Segment Uveitis - Ravi D. Vaishya; Mitan Gokulgandhi; Sulabh Patel; Mukul Minocha; Ashim K. Mitra (AAPS PharmSciTech, 2014)

Developing Ways to Evaluate in the Laboratory How Inhalation Devices Will Be Used by Patients and Care-Givers: The Need for Clinically Appropriate Testing - Jolyon P. Mitchell; Jason A. Suggett (AAPS PharmSciTech, 2014)

Encapsulation of Sorbitan Ester-Based Organogels in Alginate Microparticles - Sai S. Sagiri; Kunal Pal; Piyali Basak; Usman Ali Rana; Imran Shakir; Arfat Anis (AAPS PharmSciTech, 2014)

Inter-Grade and Inter-Batch Variability of Sodium Alginate Used in Alginate-Based Matrix Tablets - Shao Fu; Ira S. Buckner; Lawrence H. Block (AAPS PharmSciTech, 2014)

Increasing Doxycycline Hyclate Photostability by Complexation with β-Cyclodextrin - Ana Carolina Kogawa; Ariana Zoppi; Mario Alfredo Quevedo; Hérida Regina Nunes Salgado; Marcela Raquel Longhi (AAPS PharmSciTech, 2014)

Aerosol Performance and Long-Term Stability of Surfactant-Associated Liposomal Ciprofloxacin Formulations with Modified Encapsulation and Release Properties - David Cipolla; Huiying Wu; Igor Gonda; Hak-Kim Chan (AAPS PharmSciTech, 2014)
Previously, we showed that the encapsulation and release properties of a liposomal ciprofloxacin formulation could be modified post manufacture, by addition of surfactant in concert with osmotic swelling of the liposomes. This strategy may provide more flexibility and convenience than the alternative of manufacturing multiple batches of liposomes differing in composition to cover a wide range of release profiles. The goal of this study was to develop a surfactant-associated liposomal ciprofloxacin (CFI) formulation possessing good long-term stability which could be delivered as an inhaled aerosol. Preparations of 12.5 mg/ml CFI containing 0.4% polysorbate 20 were formulated between pH 4.7 and 5.5. These formulations, before and after mesh nebulization, and after refrigerated storage for up to 2 years, were characterized in terms of liposome structure by cryogenic transmission electron microscopy (cryo-TEM) imaging, vesicle size by dynamic light scattering, pH, drug encapsulation by centrifugation-filtration, and in vitro release (IVR) performance. Within the narrower pH range of 4.9 to 5.2, these formulations retained their physicochemical stability after 2-year refrigerated storage, were robust to mesh nebulization, and formed respirable aerosols with a volume mean diameter (VMD) of 3.7 μm and a geometric standard deviation (GSD) of 1.7. This study demonstrates that it may be possible to provide a range of release profiles by simple addition of surfactant to a liposomal formulation post manufacture, and that these formulations may retain their physicochemical properties after long-term refrigerated storage and following aerosolization by mesh nebulizer.

Studying the Morphology of Lyophilized Protein Solids Using X-ray Micro-CT: Effect of Post-freeze Annealing and Controlled Nucleation - Ken-ichi Izutsu; Etsuo Yonemochi; Chikako Yomota; Yukihiro Goda; Haruhiro Okuda (AAPS PharmSciTech, 2014)

A 5,7-Dimethoxyflavone/Hydroxypropyl-β-Cyclodextrin Inclusion Complex with Anti-Butyrylcholinesterase Activity - Supachai Songngam; Mongkol Sukwattanasinitt; Krisana Siralertmukul; Pattara Sawasdee (AAPS PharmSciTech, 2014)

Selective Interactions of Zein Microspheres with Different Class of Drugs: An In Vitro and In Silico Analysis - K. Karthikeyan; Ezhilarasan Vijayalakshmi; Purna Sai Korrapati (AAPS PharmSciTech, 2014)

The Practicality of Mesoporous Silica Nanoparticles as Drug Delivery Devices and Progress Toward This Goal - Robert Roggers; Shrey Kanvinde; Suthida Boonsith; David Oupický (AAPS PharmSciTech, 2014)

A New Lipid-Based Nano Formulation of Vinorelbine - Fatemeh Bahadori; Gülaçtı Topçu; Mehmet S. Eroğlu; Hayat Önyüksel (AAPS PharmSciTech, 2014)

The Effect of Polysorbate 20 on Solubility and Stability of Candesartan Cilexetil in Dissolution Media - Katarzyna Hoppe; Małgorzata Sznitowska (AAPS PharmSciTech, 2014)

Investigation of the Stabilizing Effects of Antioxidants and Benzophenone-3 on Desonide Photostability - Priscila Rosa; Ana Paula Snovarski Salla; Cristiane de Bona da Silva; Clarice Madalena Bueno Rolim; Andréa Inês Horn Adams (AAPS PharmSciTech, 2014)

Investigation of Dry Powder Inhaler (DPI) Resistance and Aerosol Dispersion Timing on Emitted Aerosol Aerodynamic Particle Sizing by Multistage Cascade Impactor when Sampled Volume Is Reduced from Compendial Value of 4 L - Hlack Mohammed; Jan Arp; Frank Chambers; Mark Copley; Volker Glaab; Mark Hammond; Derek Solomon; Kerry Bradford; Theresa Russell; Yvonne Sizer; Steven C. Nichols; Daryl L. Roberts; et al. (AAPS PharmSciTech, 2014)

Erratum to: Enhancing the Antitumor Activity of Berberine Hydrochloride by Solid Lipid Nanoparticle Encapsulation - Lu Wang; Hongtao Li; Shengpeng Wang; Rong Liu; Zhisheng Wu; Chunming Wang; Yitao Wang; Meiwan Chen (AAPS PharmSciTech, 2014)

Rheological Characterization of Cataplasm Bases Composed of Cross-Linked Partially Neutralized Polyacrylate Hydrogel - Jian Wang; Hongqin Zhang; Dianyun An; Jian Yu; Wei Li; Teng Shen; Jianxin Wang (AAPS PharmSciTech, 2014)

Preparation and Characterization of Silver Nanoparticles-Loaded Calcium Alginate Beads Embedded in Gelatin Scaffolds - Porntipa Pankongadisak; Uracha Rungsardthong Ruktanonchai; Pitt Supaphol; Orawan Suwantong (AAPS PharmSciTech, 2014)

Investigating the Dissolution Profiles of Amoxicillin, Metronidazole, and Zidovudine Formulations used in Trinidad and Tobago, West Indies - Arlene Villarroel Stuart; Jieyu Zuo; Raimar Löbenberg (AAPS PharmSciTech, 2014)

Challenges and Opportunities to Use Biowaivers to Compare Generics in China - Jieyu Zuo; Yuan Gao; Nadia Bou-Chacra; Raimar Löbenberg (AAPS PharmSciTech, 2014)

Folate-Targeted Liposome Encapsulating Chitosan/Oligonucleotide Polyplexes for Tumor Targeting - Ji Hee Kang; Gantumur Battogtokh; Young Tag Ko (AAPS PharmSciTech, 2014)

Application of Ethylcellulose Coating to Hydrophilic Matrices: A Strategy to Modulate Drug Release Profile and Reduce Drug Release Variability - Raxit Y. Mehta; Shahrzad Missaghi; Sandip B. Tiwari; Ali R. Rajabi-Siahboomi (AAPS PharmSciTech, 2014)

In Vitro Dissolution of Generic Immediate-Release Solid Oral Dosage Forms Containing BCS Class I Drugs: Comparative Assessment of Metronidazole, Zidovudine, and Amoxicillin Versus Relevant Comparator Pharmaceutical Products in South Africa and India - Nallagundla H. S. Reddy; Srinivas Patnala; Raimar Löbenberg; Isadore Kanfer (AAPS PharmSciTech, 2014)

Functionality of Disintegrants and Their Mixtures in Enabling Fast Disintegration of Tablets by a Quality by Design Approach - Parind Mahendrakumar Desai; Patrick Xuan Hua Er; Celine Valeria Liew; Paul Wan Sia Heng (AAPS PharmSciTech, 2014)

A Comparison of Granules Produced by High-Shear and Fluidized-Bed Granulation Methods - Garett Morin; Lauren Briens (AAPS PharmSciTech, 2014)

Defining the Critical Material Attributes of Lactose Monohydrate in Carrier Based Dry Powder Inhaler Formulations Using Artificial Neural Networks - Hanne Kinnunen; Gerald Hebbink; Harry Peters; Jagdeep Shur; Robert Price (AAPS PharmSciTech, 2014)

Comparative Study to Investigate the Effect of Meloxicam or Minocycline HCl In Situ Gel System on Local Treatment of Periodontal Pockets - Abeer Ahmed Kassem; Fatma Ahmed Ismail; Vivian Fahim Naggar; Elsayed Aboulmagd (AAPS PharmSciTech, 2014)

Encapsulation in Nanoparticles Improves Anti-cancer Efficacy of Carboplatin - Tanmoy Sadhukha; Swayam Prabha (AAPS PharmSciTech, 2014)

Nanoemulsion for Solubilization, Stabilization, and In Vitro Release of Pterostilbene for Oral Delivery - Yue Zhang; Zhenhua Shang; Chunhui Gao; Man Du; Shixia Xu; Haiwen Song; Tingting Liu (AAPS PharmSciTech, 2014)

In Vitro and In Vivo Performance of Dry Powder Inhalation Formulations: Comparison of Particles Prepared by Thin Film Freezing and Micronization - Yi-Bo Wang; Alan B. Watts; Jay I. Peters; Sha Liu; Ayesha Batra; Robert O. Williams (AAPS PharmSciTech, 2014)

Comparison of In Vitro Release Rates of Acyclovir from Cream Formulations Using Vertical Diffusion Cells - Sumalatha Nallagundla; Srinivas Patnala; Isadore Kanfer (AAPS PharmSciTech, 2014)

Temperature-Tunable Iron Oxide Nanoparticles for Remote-Controlled Drug Release - Raj K. Dani; Canan Schumann; Olena Taratula; Oleh Taratula (AAPS PharmSciTech, 2014)

Effect of Hydroxyl Groups and Rigid Structure in 1,4-Cyclohexanediol on Percutaneous Absorption of Metronidazole - Yan Zhang; Fengping Tan; Weipu Jia; Nan Li; Jerry Zhang (AAPS PharmSciTech, 2014)

Novel Simvastatin Inhalation Formulation and Characterisation - Alaa S. Tulbah; Hui Xin Ong; Paolo Colombo; Paul M. Young; Daniela Traini (AAPS PharmSciTech, 2014)

Transdermal Permeation of Kaempferia parviflora Methoxyflavones from Isopropyl Myristate-Based Vehicles - Sarunya Tuntiyasawasdikul; Ekapol Limpongsa; Napaphak Jaipakdee; Bungorn Sripanidkulchai (AAPS PharmSciTech, 2014)

Evaluation of Poly(2-Ethyl-2-Oxazoline) Containing Copolymer Networks of Varied Composition as Sustained Metoprolol Tartrate Delivery Systems - Bistra Kostova; Sijka Ivanova; Konstantin Balashev; Dimitar Rachev; Darinka Christova (AAPS PharmSciTech, 2014)

Formulation Development and Evaluation of Innovative Two-Polymer (SR-2P) Bioadhesive Vaginal Gel - Satheesh Podaralla; Carsten Alt; Gita N. Shankar (AAPS PharmSciTech, 2014)

In Vitro-Controlled Release Delivery System for Hydrogen Sulfide Donor - Hatim Ali; Catherine Opere; Somnath Singh (AAPS PharmSciTech, 2014)

Development and Evaluation of Ca+ 2 Ion Cross-Linked Carboxymethyl Xanthan Gum Tablet Prepared by Wet Granulation Technique - Siddhartha Maity; Biswanath Sa (AAPS PharmSciTech, 2014)

An Investigation into the Effect of Fine Lactose Particles on the Fluidization Behaviour and Aerosolization Performance of Carrier-Based Dry Powder Inhaler Formulations - Hanne Kinnunen; Gerald Hebbink; Harry Peters; Jagdeep Shur; Robert Price (AAPS PharmSciTech, 2014)

Advances in Device and Formulation Technologies for Pulmonary Drug Delivery - John Gar Yan Chan; Jennifer Wong; Qi Tony Zhou; Sharon Shui Yee Leung; Hak-Kim Chan (AAPS PharmSciTech, 2014)

Experimental and Computational Studies of Physicochemical Properties Influence NSAID-Cyclodextrin Complexation - Linda A. Felton; Carmen Popescu; Cody Wiley; Emilio Xavier Esposito; Philippe Lefevre; Anton J. Hopfinger (AAPS PharmSciTech, 2014)

Investigation of the Cytotoxic Effects of Titanate Nanotubes on Caco-2 Cells - Ferenc Fenyvesi; Zoltán Kónya; Zsolt Rázga; Miklós Vecsernyés; Péter Kása; Klára Pintye-Hódi; Ildikó Bácskay (AAPS PharmSciTech, 2014)

Polymeric Micelles: Nanocarriers for Cancer-Targeted Drug Delivery - Yifei Zhang; Yixian Huang; Song Li (AAPS PharmSciTech, 2014)

Caprylate-Conjugated Cisplatin for the Development of Novel Liposomal Formulation - Imran Vhora; Nirav Khatri; Jagruti Desai; Hetal Paresh Thakkar (AAPS PharmSciTech, 2014)

Enhancing the Antitumor Activity of Berberine Hydrochloride by Solid Lipid Nanoparticle Encapsulation - Lu Wang; Hongtao Li; Shengpeng Wang; Rong Liu; Zhisheng Wu; Chunming Wang; Yitao Wang; Meiwan Chen (AAPS PharmSciTech, 2014)

Nanocarrier for Poorly Water-Soluble Anticancer Drugs—Barriers of Translation and Solutions - Mayuri Narvekar; Hui Yi Xue; June Young Eoh; Ho Lun Wong (AAPS PharmSciTech, 2014)

Development of Novel Ionic Liquid-Based Microemulsion Formulation for Dermal Delivery of 5-Fluorouracil - Shishu Goindi; Prabhleen Arora; Neeraj Kumar; Ashana Puri (AAPS PharmSciTech, 2014)

An Explanation for the Difference in the Percutaneous Penetration Behavior of Tamsulosin Induced by Two Different O-Acylmenthol Derivatives - Lei Shang; Dongmei Cun; Honglei Xi; Liang Fang (AAPS PharmSciTech, 2014)

The Comparison of Fluid Dynamics Parameters in an Andersen Cascade Impactor Equipped With and Without a Preseparator - Janwit Dechraksa; Tan Suwandecha; Kittinan Maliwan; Teerapol Srichana (AAPS PharmSciTech, 2014)

Erratum to: Evaluation of Tadalafil Nanosuspensions and Their PEG Solid Dispersion Matrices for Enhancing Its Dissolution Properties - Wasfy M. Obeidat; Al-Sayed A. Sallam (AAPS PharmSciTech, 2014)

Particle Margination and Its Implications on Intravenous Anticancer Drug Delivery - Erik Carboni; Katherine Tschudi; Jaewook Nam; Xiuling Lu; Anson W. K. Ma (AAPS PharmSciTech, 2014)

Biodegradable Injectable In Situ Implants and Microparticles for Sustained Release of Montelukast: In Vitro Release, Pharmacokinetics, and Stability - Tarek A. Ahmed; Hany M. Ibrahim; Ahmed M. Samy; Alaa Kaseem; Mohammad T. H. Nutan; Muhammad Delwar Hussain (AAPS PharmSciTech, 2014)

Fast Tablet Tensile Strength Prediction Based on Non-Invasive Analytics - Anna Halenius; Satu Lakio; Osmo Antikainen; Juha Hatara; Jouko Yliruusi (AAPS PharmSciTech, 2014)

Nonionic Surfactant Vesicles Composed of Novel Spermine-Derivative Cationic Lipids as an Effective Gene Carrier In Vitro - Orapan Paecharoenchai; Nattisa Niyomtham; Lalita Leksantikul; Tanasait Ngawhirunpat; Theerasak Rojanarata; Boon-ek Yingyongnarongkul; Praneet Opanasopit (AAPS PharmSciTech, 2014)

Chaperone Potential of Pulicaria undulata Extract in Preventing Aggregation of Stressed Proteins - Arezou Ghahghaei; Jafar Valizadeh; Shahrzad Nazari; Mehdi Ravandeh (AAPS PharmSciTech, 2014)

Eudragit L/HPMCAS Blend Enteric-Coated Lansoprazole Pellets: Enhanced Drug Stability and Oral Bioavailability - Yu Fang; Guozheng Wang; Rong Zhang; Zhihua Liu; Zhenghua Liu; Xiaohui Wu; Deying Cao (AAPS PharmSciTech, 2014)

Best Practices for the Development, Scale-up, and Post-approval Change Control of IR and MR Dosage Forms in the Current Quality-by-Design Paradigm - Glenn A. Van Buskirk; Satish Asotra; Christopher Balducci; Prabir Basu; Gerald DiDonato; Angelica Dorantes; W. Mark Eickhoff; Tapash Ghosh; Mario A. González; Theresa Henry; Matthew Howard; Jason Kamm; et al. (AAPS PharmSciTech, 2014)

Application of Carrier and Plasticizer to Improve the Dissolution and Bioavailability of Poorly Water-Soluble Baicalein by Hot Melt Extrusion - Yilan Zhang; Rui Luo; Yi Chen; Xue Ke; Danrong Hu; Miaomiao Han (AAPS PharmSciTech, 2014)

Mechanisms of Pharmaceutical Aerosol Deposition in the Respiratory Tract - Yung Sung Cheng (AAPS PharmSciTech, 2014)

A Systematic Approach to Design and Prepare Solid Dispersions of Poorly Water-Soluble Drug - Sanjay Verma; Varma S. Rudraraju (AAPS PharmSciTech, 2014)

Considerations for a Pediatric Biopharmaceutics Classification System (BCS): Application to Five Drugs - Shivani V. Gandhi; William Rodriguez; Mansoor Khan; James E. Polli (AAPS PharmSciTech, 2014)

Effect of Lipolysis on Drug Release from Self-microemulsifying Drug Delivery Systems (SMEDDS) with Different Core/Shell Drug Location - Jianbin Zhang; Yan Lv; Shan Zhao; Bing Wang; Mingqian Tan; Hongguo Xie; Guojun Lv; Xiaojun Ma (AAPS PharmSciTech, 2014)

Moistening Liquid-Dependent De-aggregation of Microcrystalline Cellulose and Its Impact on Pellet Formation by Extrusion–Spheronization - Srimanta Sarkar; Celine Valeria Liew (AAPS PharmSciTech, 2014)

Light-Activatable Gold Nanoshells for Drug Delivery Applications - Burapol Singhana; Patrick Slattery; Aaron Chen; Michael Wallace; Marites P. Melancon (AAPS PharmSciTech, 2014)

Nanodrug Delivery Systems: A Promising Technology for Detection, Diagnosis, and Treatment of Cancer - Anish Babu; Amanda K. Templeton; Anupama Munshi; Rajagopal Ramesh (AAPS PharmSciTech, 2014)

Whey Protein/Polysaccharide-Stabilized Emulsions: Effect of Polymer Type and pH on Release and Topical Delivery of Salicylic Acid - Johann Combrinck; Anja Otto; Jeanetta du Plessis (AAPS PharmSciTech, 2014)

Influence of Processing Parameters and Formulation Factors on the Bioadhesive, Temperature Stability and Drug Release Properties of Hot-Melt Extruded Films Containing Miconazole - Meiwan Chen; Jiannan Lu; Weibin Deng; Abhilasha Singh; Noorullah Naqvi Mohammed; Michael A. Repka; Chuanbin Wu (AAPS PharmSciTech, 2014)

Application of QbD Principles for the Evaluation of Empty Hard Capsules as an Input Parameter in Formulation Development and Manufacturing - Sven Stegemann; Paul Connolly; Wayne Matthews; Rodger Barnett; Mike Aylott; Karin Schrooten; Dominique Cadé; Anthony Taylor; Massimo Bresciani (AAPS PharmSciTech, 2014)
Understanding the product and process variable on the final product performance is an essential part of the quality-by-design (QbD) principles in pharmaceutical development. The hard capsule is an established pharmaceutical dosage form used worldwide in development and manufacturing. The empty hard capsules are supplied as an excipient that is filled by pharmaceutical manufacturers with a variety of different formulations and products. To understand the potential variations of the empty hard capsules as an input parameter and its potential impact on the finished product quality, a study was performed investigating the critical quality parameters within and in between different batches of empty hard gelatin capsules. The variability of the hard capsules showed high consistency within the specification of the critical quality parameters. This also accounts for the disintegration times, when automatic endpoint detection was used. Based on these data, hard capsules can be considered as a suitable excipient for product development using QbD principles.

A Short Term Quality Control Tool for Biodegradable Microspheres - Susan D’Souza; Jabar A. Faraj; Rossella Dorati; Patrick P. DeLuca (AAPS PharmSciTech, 2014)

Liposomal Oxymatrine in Hepatic Fibrosis Treatment: Formulation, In Vitro and In Vivo Assessment - Shujuan Zhang; Jun Wu; Hua Wang; Tiechuang Wang; Lina Jin; Dandan Shu; Weiguang Shan; Subin Xiong (AAPS PharmSciTech, 2014)

Nanoemulsions in Translational Research—Opportunities and Challenges in Targeted Cancer Therapy - Srinivas Ganta; Meghna Talekar; Amit Singh; Timothy P. Coleman; Mansoor M. Amiji (AAPS PharmSciTech, 2014)

Influence of the Freeze-Drying Process on the Physicochemical and Biological Properties of Pre-heated Amphotericin B Micellar Systems - Scheyla D. V. S. Siqueira; Miguel A. Silva-Filho; Christian A. Silva; Ivonete B. Araújo; Acarilia E. Silva; Matheus F. Fernandes-Pedrosa; Anselmo G. Oliveira; E. Sócrates T. Egito (AAPS PharmSciTech, 2014)

Effect of Acetate and Carbonate Buffers on the Photolysis of Riboflavin in Aqueous Solution: A Kinetic Study - Iqbal Ahmad; Zubair Anwar; Kefi Iqbal; Syed Abid Ali; Tania Mirza; Adeela Khurshid; Aqeela Khurshid; Adeel Arsalan (AAPS PharmSciTech, 2014)

Statistical Design for Formulation Optimization of Hydrocortisone Butyrate-Loaded PLGA Nanoparticles - Xiaoyan Yang; Sulabh Patel; Ye Sheng; Dhananjay Pal; Ashim K. Mitra (AAPS PharmSciTech, 2014)

Retraction Note: Design and Formulation Technique of a Novel Drug Delivery System for Azithromycin and its Anti-Bacterial Activity Against Staphylococcus aureus - M. Joyce Nirmala; Amitava Mukherjee; N. Chandrasekaran (AAPS PharmSciTech, 2014)

Neem Gum as a Binder in a Formulated Paracetamol Tablet with Reference to Acacia Gum BP - Abayomi Tolulope Ogunjimi; Gbenga Alebiowu (AAPS PharmSciTech, 2014)

Retraction Note: Meloxicam Taste-Masked Oral Disintegrating Tablet with Dissolution Enhanced by Ion Exchange Resins and Cyclodextrin - Wipada Samprasit; Prasert Akkaramongkolporn; Tanasait Ngawhirunpat; Theerasak Rojanarata; Praneet Opanasopit (AAPS PharmSciTech, 2014)

Report from the 2nd annual RICiFa meeting (International Meeting on Pharmaceutical Sciences 2012) - Claudio J. Salomon; Santiago D. Palma (AAPS PharmSciTech, 2014)

Mixed Polyethylene Glycol-Modified Breviscapine-Loaded Solid Lipid Nanoparticles for Improved Brain Bioavailability: Preparation, Characterization, and In Vivo Cerebral Microdialysis Evaluation in Adult Sprague Dawley Rats - Zhidong Liu; Chukwunweike Ikechukwu Okeke; Li Zhang; Hainan Zhao; Jiawei Li; Mike Okweesi Aggrey; Nan Li; Xiujun Guo; Xiaochen Pang; Lili Fan; Lili Guo (AAPS PharmSciTech, 2014)

SN-38-Cyclodextrin Complexation and Its Influence on the Solubility, Stability, and In Vitro Anticancer Activity Against Ovarian Cancer - Kiran Kumar Vangara; Hamed Ismail Ali; Dai Lu; Jingbo Louise Liu; Srikanth Kolluru; Srinath Palakurthi (AAPS PharmSciTech, 2014)

The Role of Caprylate Ligand Ion on the Stabilization of Human Serum Albumin - Damrongsak Faroongsarng; Jaturavit Kongprasertkit (AAPS PharmSciTech, 2014)

Self-Nanoemulsifying Drug Delivery System of Nifedipine: Impact of Hydrophilic–Lipophilic Balance and Molecular Structure of Mixed Surfactants - Yotsanan Weerapol; Sontaya Limmatvapirat; Jurairat Nunthanid; Pornsak Sriamornsak (AAPS PharmSciTech, 2014)

Advances in Metered Dose Inhaler Technology: Formulation Development - Paul B. Myrdal; Poonam Sheth; Stephen W. Stein (AAPS PharmSciTech, 2014)

Encapsulation of Acetylshikonin by Polyamidoamine Dendrimers for Preparing Prominent Nanoparticles - Jianqing Peng; Wen Zhou; Xinyi Xia; Xiaole Qi; Luan Sun; Min Wang; Zhenghong Wu; Zhengrong Li (AAPS PharmSciTech, 2014)

Efficacy, Pharmacokinetics, and Biodistribution of Thermosensitive Chitosan/β-Glycerophosphate Hydrogel Loaded with Docetaxel - Cuiyun Li; Shuangxia Ren; Yu Dai; Fengjie Tian; Xin Wang; Sufeng Zhou; Shuhua Deng; Qi Liu; Jie Zhao; Xijing Chen (AAPS PharmSciTech, 2014)

From Bench to Humans: Formulation Development of a Poorly Water Soluble Drug to Mitigate Food Effect - Preetanshu Pandey; Rhye Hamey; Dilbir S. Bindra; Zongyun Huang; Neil Mathias; Timothy Eley; John Crison; Brian Yan; Robert Perrone; Chandra Vemavarapu (AAPS PharmSciTech, 2014)

Application of Physiologically Based Absorption Modeling to Formulation Development of a Low Solubility, Low Permeability Weak Base: Mechanistic Investigation of Food Effect - Hefei Zhang; Binfeng Xia; Jennifer Sheng; Tycho Heimbach; Tsu-Han Lin; Handan He; Yanfeng Wang; Steven Novick; Ann Comfort (AAPS PharmSciTech, 2014)

Dendrimer, Liposomes, Carbon Nanotubes and PLGA Nanoparticles: One Platform Assessment of Drug Delivery Potential - Nishi Mody; Rakesh Kumar Tekade; Neelesh Kumar Mehra; Prashant Chopdey; Narendra Kumar Jain (AAPS PharmSciTech, 2014)

Assessment of Active Pharmaceutical Ingredient Particle Size in Tablets by Raman Chemical Imaging Validated using Polystyrene Microsphere Size Standards - Atsushi Kuriyama; Yukihiro Ozaki (AAPS PharmSciTech, 2014)

Evaluation of Tadalafil Nanosuspensions and Their PEG Solid Dispersion Matrices for Enhancing Its Dissolution Properties - Wasfy M. Obeidat; Al-Sayed A. Sallam (AAPS PharmSciTech, 2014)

Effect of Hydrocarbon Chain Length in 1,2-Alkanediols on Percutaneous Absorption of Metronidazole: Toward Development of a General Vehicle for Controlled Release - Nan Li; Weibu Jia; Yan Zhang; Michelle C. Zhang; Fengping Tan; Jerry Zhang (AAPS PharmSciTech, 2014)

A Prospective Analysis of Co-Processed Non-Ionic Surfactants in Enhancing Permeability of a Model Hydrophilic Drug - Mohammed M. Alvi; Parnali Chatterjee (AAPS PharmSciTech, 2014)

Advances in Metered Dose Inhaler Technology: Hardware Development - Stephen W. Stein; Poonam Sheth; P. David Hodson; Paul B. Myrdal (AAPS PharmSciTech, 2014)