Stimulatory Effects of Soluplus® on Flufenamic Acid β-Cyclodextrin Supramolecular Complex: Physicochemical Characterization and Pre-clinical Anti-inflammatory Assessment - Sultan Alshehri; Syed Sarim Imam; Mohammad A. Altamimi; Afzal Hussain; Faiyaz Shakeel; Abdulhakeem Alshehri (AAPS PharmSciTech, 2020)

Correction to: Development of Nanocrystal Ziprasidone Orally Disintegrating Tablets: Optimization by Using Design of Experiment and In Vitro Evaluation - Emine Tashan; Alptug Karakucuk; Nevin Celebi (AAPS PharmSciTech, 2020)

Spray-Dried Proliposomes: an Innovative Method for Encapsulation of Rosmarinus officinalis L. Polyphenols - Victor Oloruntoba Bankole; Michael Oluwole Osungunna; Claudia Regina Fernandes Souza; Sergio Luiz Salvador; Wanderley Pereira Oliveira (AAPS PharmSciTech, 2020)
This work aims to improve the functionality of Rosmarinus officinalis L. (rosemary) polyphenols by encapsulation in an optimized proliposome formulation. A 2 3 Box-Wilson central composite design (CCD) was employed to determine lone and interaction effects of composition variables on moisture content ( X p ); water activity ( A w ); concentration and retention of rosemary polyphenols—rosmarinic acid (ROA), carnosol (CAR), and carnosic acid (CNA); and recovery of spray-dried proliposomes (SDP). Processing conditions which generate proliposomes with optimum physicochemical properties were determined by multi-response analysis (desirability approach). Antioxidant and antifungal activities were evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH • ) sequestering and minimum inhibitory concentration (MIC)/minimum fungicidal concentration (MFC) assays, respectively. SDP exhibited high polyphenol retention, ranging from 62.0 to 100.0% w/w, showing dependence on composition variables and polyphenol lipophilicity. SDP recovery ranged from 20.1 to 45.8%, with X p and A w of 1.7 ± 0.14–2.5 ± 0.23% w/w and 0.30 ± 0.004–0.47 ± 0.003, respectively, evidencing product with good chemical and microbiological stability. Optimum liposomal composition was determined, namely, lipid concentration (4.26% w/w), lyophilized extract (LE) concentration (4.48% w/w), and drying aid:(lipid+extract) ratio (7.55% w/w) on wet basis. Relative errors between experimental and predicted values for SDP properties showed concurrence for all responses except CAR retention, being 22% lower. SDP showed high antioxidant activity with IC 50 of 9.2 ± 0.2 μg/mL, superior to results obtained for LE (10.8 μg/mL) and butylated hydroxytoluene (BHT), a synthetic antioxidant (12.5 μg/mL). MIC and MFC against Candida albicans (ATCC1023) were 312.5 μg/mL and 1250 μg/mL, respectively, a moderate antimicrobial activity for phytochemical-based products. SDP is shown as a veritable tool to encapsulate hydrophilic and lipophilic rosemary polyphenols generating a product with optimal physicochemical and biological properties.

MUCO-DIS: a New AFM-Based Nanoscale Dissolution Technique - Muhammad Usman Ghori; Jorabar Singh Nirwan; Taimoor Asim; Younes Chahid; Samia Farhaj; Zara Khizer; Peter Timmins; Barbara R. Conway (AAPS PharmSciTech, 2020)
Mucoadhesion-based drug delivery systems have recently gained interest because of their bio-adhesion capability, which results in enhanced residence time leading to prolonged duration of action with the mucosal surface, potentially improving compliance and convenience. Mucoadhesion testing of these formulations is widely reported; however, this is technically challenging due to the absence of any standard methods and difficulty in conducting mucoadhesion, formulation-mucosal surface interaction, mucosal surface topography and drug release in a single experiment. As these measurements are currently conducted separately, on replicate formulations, results can often be subjective and difficult to correlate. Hence, the aim of the present study was to develop a new AFM-based single-entity ex vivo muco-dissolution (MUCO-DIS) technique to simultaneously evaluate mucoadhesion force, 3D surface topography, polymer dissolution and drug release characteristics. To demonstrate the potential of the current technique, the interactions between model pectin microparticles containing metformin HCl and a range of gastrointestinal mucosal surfaces (gastric, small intestine, large intestine and buccal) were studied. This novel system has not only successfully determined the mucoadhesion force, polymer dissolution and drug release information but has also highlighted the difference in microparticle performance with different mucosal targets. The current work has highlighted the potential of this newly developed MUCO-DIS system and we believe this will be a valuable tool for characterising these popular pharmaceutical formulations. This technique could also provide an opportunity to other scientific fields to evaluate materials, substrate behaviour and their interactions in their hydrated state at nanoscale with real-time chemical and surface mapping.

Chewable Antacid Tablets: Are Disintegration Tests Relevant? - Nasser N. Nyamweya; Samantha N. Kimani; Kennedy O. Abuga (AAPS PharmSciTech, 2020)

Formulation, Optimization and Evaluation of Novel Ultra-deformable Vesicular Drug Delivery System for an Anti-fungal Drug - Devika Nayak; Roshan M. Tawale; Jesil Mathew Aranjani; Vamshi Krishna Tippavajhala (AAPS PharmSciTech, 2020)

The Application of Coarse-Grained Molecular Dynamics to the Evaluation of Liposome Physical Stability - Liping Chen; Zhimin Wu; Xiaowen Wu; Yuyao Liao; Xingxing Dai; Xinyuan Shi (AAPS PharmSciTech, 2020)

An NMR Protocol for In Vitro Paclitaxel Release from an Albumin-Bound Nanoparticle Formulation - Min Sung Suh; Sharadrao M. Patil; Darby Kozak; Eric Pang; Stephanie Choi; Xiaohui Jiang; Jason D. Rodriguez; David A. Keire; Kang Chen (AAPS PharmSciTech, 2020)

Self-Emulsifying Drug Delivery System of Celecoxib for Avoiding Delayed Oral Absorption in Rats with Impaired Gastric Motility - Keisuke Yakushiji; Hideyuki Sato; Mizuki Ogino; Hiroki Suzuki; Yoshiki Seto; Satomi Onoue (AAPS PharmSciTech, 2020)

RETRACTED ARTICLE: Hyaluronic Acid-Pluronic®F127-Laden Soft Contact Lenses for Corneal Epithelial Healing: In Vitro and In Vivo Studies - Ning Wei; Xianghui Xu; Chao Huang; Lijun Cao (AAPS PharmSciTech, 2020)

RETRACTED ARTICLE: EGFR Targeted Paclitaxel and Piperine Co-loaded Liposomes for the Treatment of Triple Negative Breast Cancer - Ankita Sanjay Burande; Matte Kasi Viswanadh; Abhishek Jha; Abhishesh Kumar Mehata; Azad Shaik; Nishi Agrawal; Suruchi Poddar; Sanjeev Kumar Mahto; Madaswamy S. Muthu (AAPS PharmSciTech, 2020)

RETRACTED ARTICLE: Poloxamer-407-Co-Poly (2-Acrylamido-2-Methylpropane Sulfonic Acid) Cross-linked Nanogels for Solubility Enhancement of Olanzapine: Synthesis, Characterization, and Toxicity Evaluation - Kifayat Ullah Khan; Naveed Akhtar; Muhammad Usman Minhas (AAPS PharmSciTech, 2020)

RETRACTED ARTICLE: ArticleNoteOptimization of Thymoquinone-Loaded Coconut Oil Nanostructured Lipid Carriers for the Management of Ethanol-Induced Ulcer - Usama A. Fahmy; Ahmed L. Alaofi; Zuhier A. Awan; Hani M. Alqarni; Nabil A. Alhakamy (AAPS PharmSciTech, 2020)

Evaluation of the Physico-mechanical Properties and Electrostatic Charging Behavior of Different Capsule Types for Inhalation Under Distinct Environmental Conditions - Joana T. Pinto; Thomas Wutscher; Milica Stankovic-Brandl; Sarah Zellnitz; Stefano Biserni; Alberto Mercandelli; Mirjam Kobler; Francesca Buttini; Laura Andrade; Veronica Daza; Susana Ecenarro; Laura Canalejas; et al. (AAPS PharmSciTech, 2020)
Capsule-based dry powder inhaler (DPI) products can be influenced by a multitude of interacting factors, including electrostatic charging. Tribo-charging is a process of charge transfer impacted by various factors, i.e. , material surface characteristics, mechanical properties, processing parameters and environmental conditions. Consequently, this work aimed to assess how the charging behavior of capsules intended for inhalation might be influenced by environmental conditions. Capsules having different chemical compositions (gelatin and hydroxypropyl methylcellulose (HPMC)) and distinct inherent characteristics from manufacturing (thermally and cold-gelled) were exposed to various environmental conditions (11%, 22% and 51% RH). Their resulting properties were characterized and tribo-charging behavior was measured against stainless steel and PVC. It was observed that all capsule materials tended to charge to a higher extent when in contact with PVC. The tribo-charging of the thermally gelled HPMC capsules (Vcaps ® Plus) was more similar to the gelatin capsules (Quali-G™-I) than to their HPMC cold-gelled counterparts (Quali-V ® -I). The sorption of water by the capsules at different relative humidities notably impacted their properties and tribo-charging behavior. Different interactions between the tested materials and water molecules were identified and are proposed to be the driver of distinct charging behaviors. Finally, we showed that depending on the capsule types, distinct environmental conditions are necessary to mitigate charging and assure optimal behavior of the capsules.

Cationic Polylactic Acid-Based Nanoparticles Improve BSA-FITC Transport Across M Cells and Engulfment by Porcine Alveolar Macrophages - Puwich Chaikhumwang; Jutarat Kitsongsermthon; Kasorn Manopakdee; Wanchai Chongcharoen; Dachrit Nilubol; Pithi Chanvorachote; Poorichya Somparn; Angkana Tantituvanont (AAPS PharmSciTech, 2020)

The Stabilizing Excipients in Dry State Therapeutic Phage Formulations - Yajie Zhang; Hairui Zhang; Debadyuti Ghosh (AAPS PharmSciTech, 2020)

Factors Influencing the Delivery Efficiency of Cancer Nanomedicines - Rahat Ullah; Junaid Wazir; Farhan Ullah Khan; Maladho Tanta Diallo; Awais Ullah Ihsan; Reyaj Mikrani; Md Aquib; Xiaohui Zhou (AAPS PharmSciTech, 2020)

Research Progress of Drug Treatment in Novel Coronavirus Pneumonia - Junqiang Yan; Anran Liu; Jiarui Huang; Jiannan Wu; Hua Fan (AAPS PharmSciTech, 2020)

In Vitro Release of 5-Fluorouracil and Methotrexate from Different Thermosensitive Chitosan Hydrogel Systems - Ahmed M. Mohammed; Shaaban K. Osman; Khaled I. Saleh; Ahmed M. Samy (AAPS PharmSciTech, 2020)
5-Fluorouracil is a member of cytotoxic drugs with poor selectivity to cancer cells. Currently, systemic administration of this anti-cancer drug (oral or injection) exposes normal tissues to the drug-induced toxicity. Nowadays, attention has been greatly directed towards in situ gel-forming systems that can be injected into the affected tissues in its sol form with a minimally invasive technique. More specifically, chitosan hydrogel systems were in focus due to their antibacterial effect as well as their biodegradable, biocompatible, and mucoadhesive properties. In the present work, 5-fluorouracil was loaded on various thermosensitive chitosan hydrogel systems cross linked with different linking agents like β-glycerophosphate, pluronic F127, and hydroxyapatite. Also, methotrexate was added to 5-fluorouracil in order to gain its previously reported synergistic effects. Firstly, a compatibility study was performed using UV-spectrophotometric, infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) techniques to exclude the possibility of any physical or chemical interactions between the selected drugs and excipients. The prepared hydrogel systems were characterized for their physicochemical properties including organoleptic, pH, syringeability and injectability, viscosity, and gelation temperature ( T gel ) by various analysis techniques. Moreover , the in vitro release behavior of 5-fluorouracil and methotrexate was determined with a modified analytical method. The results indicated that chitosan hydrogel system cross-linked with a combination of β- glycerophosphate, and 10 % pluronicF127 (F4) showed the most suitable physicochemical properties and release profile. Accordingly, this formula can be considered as a missionary system for localized sustained delivery of cytotoxic drugs.

Characterization, Optimization, In Vitro and In Vivo Evaluation of Simvastatin Proliposomes, as a Drug Delivery - Mohamed Rahamathulla; Gangadharappa H.V; Gangadhar Veerapu; Umme Hani; Yahya Alhamhoom; Ali Alqahtani; Afrasim Moin (AAPS PharmSciTech, 2020)

Quality Risk Management and Quality by Design for the Development of Diclofenac Sodium Intra-articular Gelatin Microspheres - Alexandros Nakas; Athanasia M. Dalatsi; Afroditi Kapourani; Konstantinos N. Kontogiannopoulos; Andreana N. Assimopoulou; Panagiotis Barmpalexis (AAPS PharmSciTech, 2020)

A Novel Technique to Improve Drug Loading Capacity of Fast/Extended Release Orally Dissolving Films with Potential for Paediatric and Geriatric Drug Delivery - Gailany I. Ouda; Eman Z. Dahmash; Hamad Alyami; Affiong Iyire (AAPS PharmSciTech, 2020)

Synthesis and Characterization of Nanostructured Lipid Nanocarriers for Enhanced Sun Protection Factor of Octyl p-methoxycinnamate - Alice Haddad do Prado; Victor Hugo Sousa Araújo; Josimar O. Eloy; Bruno Fonseca-Santos; Marcelo A. Pereira-da-Silva; Rosângela Gonçalves Peccinini; Marlus Chorilli (AAPS PharmSciTech, 2020)

SP94 Peptide-Functionalized PEG-PLGA Nanoparticle Loading with Cryptotanshinone for Targeting Therapy of Hepatocellular Carcinoma - Xiaoling Nie; Yuan Liu; Ming Li; Xuesong Yu; Wanwen Yuan; Sixi Huang; Di Ren; Ying Wang; Yan Wang (AAPS PharmSciTech, 2020)

The Role of Surface Properties on Protein Aggregation Behavior in Aqueous Solution of Different pH Values - Hairong Lan; Huijun Liu; Yalin Ye; Zongning Yin (AAPS PharmSciTech, 2020)

Evaluation of Mogroside V as a Promising Carrier in Drug Delivery: Improving the Bioavailability and Liver Distribution of Silybin - Yuqin Luo; Chunyan Gong; Mingmin Wei; Yi Chen; Ting Song; Chunyong Wu; Liying Mo; Junying Zhang (AAPS PharmSciTech, 2020)

Chemotherapeutic Efficacy Enhancement in P-gp-Overexpressing Cancer Cells by Flavonoid-Loaded Polymeric Micelles - Ruttiros Khonkarn; Krai Daowtak; Siriporn Okonogi (AAPS PharmSciTech, 2020)

Cold Flow Evaluation in Transdermal Drug Delivery Systems by Measuring the Width of the Oozed Adhesive - Tamaki Miyazaki; Hitomi Kanno; Eiichi Yamamoto; Daisuke Ando; Ken-ich Izutsu; Yukihiro Goda (AAPS PharmSciTech, 2020)

Preparation, Physicochemical Characterisation and DoE Optimisation of a Spray-Dried Dry Emulsion Platform for Delivery of a Poorly Soluble Drug, Simvastatin - Mitja Pohlen; Zoran Lavrič; Clive Prestidge; Rok Dreu (AAPS PharmSciTech, 2020)

Improved Oral Pharmacokinetics of Pentoxifylline with Palm Oil and Capmul® MCM Containing Self-Nano-Emulsifying Drug Delivery System - Ashay Manisha Shailendrakumar; Vivek M. Ghate; Manas Kinra; Shaila A. Lewis (AAPS PharmSciTech, 2020)

Determination of Rate and Extent of Scopolamine Release from Transderm Scōp® Transdermal Drug Delivery Systems in Healthy Human Adults - Suresh Kumar Swaminathan; Caroline Strasinger; Megan Kelchen; Jamie Carr; Wei Ye; Anna Wokovich; Priyanka Ghosh; Srinivasan Rajagopal; Kenichi Ueda; James Fisher; Karunya K. Kandimalla; Nicole K. Brogden (AAPS PharmSciTech, 2020)

The Route to Palatable Fecal Microbiota Transplantation - Hala M. Fadda (AAPS PharmSciTech, 2020)

Development of Nanocrystal Ziprasidone Orally Disintegrating Tablets: Optimization by Using Design of Experiment and In Vitro Evaluation - Emine Tashan; Alptug Karakucuk; Nevin Celebi (AAPS PharmSciTech, 2020)

Quantification of Monomer Units in Insoluble Polymeric Active Pharmaceutical Ingredients Using Solid-State NMR Spectroscopy I: Patiromer - Travis W. Jarrells; Deyi Zhang; Shaohua Li; Eric J. Munson (AAPS PharmSciTech, 2020)

Novel Enhanced Therapeutic Efficacy of Dapoxetine HCl by Nano-Vesicle Transdermal Gel for Treatment of Carrageenan-Induced Rat Paw Edema - Heba F. Salem; Mohamed M. Nafady; Rasha M. Kharshoum; Omnia A. Abd el-Ghafar; Hanan O. Farouk (AAPS PharmSciTech, 2020)

A Novel Prototype Device for Microencapsulation of Benznidazole: In Vitro/In Vivo Studies - María G. Barrera; Guillermo Tejada; Darío Leonardi; María C. Lamas; Claudio J. Salomón (AAPS PharmSciTech, 2020)

Data-Driven Modeling of the Bicalutamide Dissolution from Powder Systems - Aleksander Mendyk; Adam Pacławski; Joanna Szafraniec-Szczęsny; Agata Antosik; Witold Jamróz; Marian Paluch; Renata Jachowicz (AAPS PharmSciTech, 2020)
Low solubility of active pharmaceutical compounds (APIs) remains an important challenge in dosage form development process. In the manuscript, empirical models were developed and analyzed in order to predict dissolution of bicalutamide (BCL) from solid dispersion with various carriers. BCL was chosen as an example of a poor water-soluble API. Two separate datasets were created: one from literature data and another based on in-house experimental data. Computational experiments were conducted using artificial intelligence tools based on machine learning (AI/ML) with a plethora of techniques including artificial neural networks, decision trees, rule-based systems, and evolutionary computations. The latter resulting in classical mathematical equations provided models characterized by the lowest prediction error. In-house data turned out to be more homogeneous, as well as formulations were more extensively characterized than literature-based data. Thus, in-house data resulted in better models than literature-based data set. Among the other covariates, the best model uses for prediction of BCL dissolution profile the transmittance from IR spectrum at 1260 cm −1 wavenumber. Ab initio modeling–based in silico simulations were conducted to reveal potential BCL–excipients interaction. All crucial variables were selected automatically by AI/ML tools and resulted in reasonably simple and yet predictive models suitable for application in Quality by Design (QbD) approaches. Presented data-driven model development using AI/ML could be useful in various problems in the field of pharmaceutical technology, resulting in both predictive and investigational tools revealing new knowledge.

Combined Therapy for Alzheimer’s Disease: Tacrine and PAMAM Dendrimers Co-Administration Reduces the Side Effects of the Drug without Modifying its Activity - Daniela E. Igartúa; Carolina S. Martinez; Silvia del V. Alonso; M. Jimena Prieto (AAPS PharmSciTech, 2020)

Transdermal Delivery of the Free Base of 3-Fluoroamphetamine: In Vitro Skin Permeation and Irritation Potential - Ying Jiang; Kevin S. Murnane; Bruce E. Blough; Ajay K. Banga (AAPS PharmSciTech, 2020)

Lyophilisation Improves Bioactivity and Stability of Insulin-Loaded Polymeric-Oligonucleotide Nanoparticles for Diabetes Treatment - Chun Y. Wong; Hani Al-Salami; Crispin R. Dass (AAPS PharmSciTech, 2020)

The Opposed Effects of Polyvinylpyrrolidone K30 on Dissolution and Precipitation for Indomethacin Supersaturating Drug Delivery Systems - Wenxi Wang; Mengting Li; Qingliang Yang; Qing Liu; Mengdie Ye; Gensheng Yang (AAPS PharmSciTech, 2020)

Effects of Uncleavable and Cleavable PEG-Lipids with Different Molecular Weights on Accelerated Blood Clearance of PEGylated Emulsions in Beagle Dogs - Jiao Jiao; Xiang Luo; Chunling Wang; Xiaoqin Jiao; Mengyang Liu; Xinrong Liu; Liting Wei; Yihui Deng; Yanzhi Song (AAPS PharmSciTech, 2020)

Liquisolid System and Liqui-Mass System Are Not the Same - Matthew Lam; Taravat Ghafourian; Ali Nokhodchi (AAPS PharmSciTech, 2020)
This commentary is written in response to Pezzini’s research group commentary, which claimed Liqui-Pellet and liquisolid pellet are not different. Despite some similarities, there are crucial differences separating these two technologies. Liqui-Pellet uses liqui-mass system (wet mass/paste admixture), and liquisolid pellet uses liquisolid system (flowable powder admixture). The understanding of the well-defined term ‘liquisolid system’ is crucial to understand what is and is not liquisolid formulation. Spireas, who is the inventor of liquisolid technology, clearly defined liquisolid system in his patent document and publications. Since his first publication in 1998, there are around 200 articles about liquisolid formulations (extracted from Scopus), and with no exception, every single one of them followed the original definition of liquisolid system. Liqui-Pellet does not use liquisolid system and so calling it the same as liquisolid pellet, which uses liquisolid system, is incorrect and misleading. The purpose of this commentary is to resolve misunderstanding and support furthering knowledge.

Effects of Diluents on Physical and Chemical Stability of Phenytoin and Phenytoin Sodium - Ziyaur Rahman; Sathish Dharani; Sogra F. Barakh Ali; Mohammad T. H. Nutan; Mansoor A. Khan (AAPS PharmSciTech, 2020)

Simulation of Unit Operations in Formulation Development of Tablets Using Computational Fluid Dynamics - S Hemamanjushree; Vamshi Krishna Tippavajhala (AAPS PharmSciTech, 2020)

Formulation and Clinical Evaluation of Sodium Benzoate Oral Solution for the Treatment of Urea Cycle Disorders in Pediatric Patients - E. Maines; S. A. M. Urru; E. Burri; G. Piccoli; A. Pedrolli; A. Pasqualini; A. L. Burlina; G. Temporin (AAPS PharmSciTech, 2020)

Food Protein-Based Nanodelivery Systems for Hydrophobic and Poorly Soluble Compounds - Mily Bazezy Joelle Maviah; Muhammad Asim Farooq; Rukhshona Mavlyanova; Hanitrarimalala Veroniaina; Mensura Sied Filli; Md Aquib; Samuel Kesse; Kofi Oti Boakye-Yiadom; Bo Wang (AAPS PharmSciTech, 2020)

Understanding the Oral Absorption of Irbesartan Using Biorelevant Dissolution Testing and PBPK Modeling - Navpreet Kaur; Poonam Singh Thakur; Ganesh Shete; Rahul Gangwal; Abhay T. Sangamwar; Arvind Kumar Bansal (AAPS PharmSciTech, 2020)

Development of Abuse-Deterrent Formulations Using Sucrose Acetate Isobutyrate - Sogra F. Barakh Ali; Sathish Dharani; Hamideh Afrooz; Eman M. Mohamed; Phillip Cook; Mansoor A. Khan; Ziyaur Rahman (AAPS PharmSciTech, 2020)

Optimization and Evaluation of the Thermosensitive In Situ and Adhesive Gel for Rectal Delivery of Budesonide - Lin Chen; Xue Han; Xiaohong Xu; Quan Zhang; Yingchun Zeng; Qing Su; Yujie Liu; Yanmei Sheng; Xingliang Xie (AAPS PharmSciTech, 2020)

Simulation of the Pharmacokinetics of Oseltamivir and Its Active Metabolite in Normal Populations and Patients with Hepatic Cirrhosis Using Physiologically Based Pharmacokinetic Modeling - Yong Chen; Meng Ke; Jianwen Xu; Cuihong Lin (AAPS PharmSciTech, 2020)

Predicting Density of Amorphous Solid Materials Using Molecular Dynamics Simulation - Mustafa Bookwala; Kevin DeBoyace; Ira S. Buckner; Peter L. D. Wildfong (AAPS PharmSciTech, 2020)

Protecting the Normal Physiological Functions of Articular and Periarticular Structures by Aurum Nanoparticle-Based Formulations: an Up-to-Date Insight - Paras Famta; Mani Famta; Jaskiran Kaur; Rubiya Khursheed; Amanjot Kaur; Gopal L. Khatik; Datta Maroti Pawde; Syed Nazrin Ruhina Rahman; Tamilvanan Shunmugaperumal (AAPS PharmSciTech, 2020)

Structure-Properties Relationship in the Evaluation of Alginic Acid Functionality for Tableting - Rihab Benabbas; Noelia M. Sanchez-Ballester; Bernard Bataille; Laurent Leclercq; Tahmer Sharkawi; Ian Soulairol (AAPS PharmSciTech, 2020)

Correction to: Development of Methotrexate and Minocycline Loaded Nanoparticles for the Effective Treatment of Rheumatoid Arthritis - Kumar Janakiraman; Venkateshwaran Krishnaswami; Vaidevi Sethuraman; Subramanian Natesan; Vijaya Rajendran; Ruckmani Kandasamy (AAPS PharmSciTech, 2020)

Exploring the Potential of Hydrophilic Matrix Combined with Insoluble Film Coating: Preparation and Evaluation of Ambroxol Hydrochloride Extended Release Tablets - Manyu Hu; Zhuangzhi Zhu; Yubo Wu; Qingqing Meng; Jing Luo; Hao Wang (AAPS PharmSciTech, 2020)

Comparative Bioavailability of Oral Granule Formulations of the HIV Antiretroviral Drugs Doravirine, Lamivudine, and Tenofovir Disoproxil Fumarate - Ka Lai Yee; Adrienne DiBenedetto; Li Fan; Sauzanne Khalilieh; Ilias Triantafyllou; Marie-Helene Vallee; Paul Fackler; S. Aubrey Stoch; Marian Iwamoto (AAPS PharmSciTech, 2020)

Fabrication of Fine Puerarin Nanocrystals by Box–Behnken Design to Enhance Intestinal Absorption - Meng Cheng; Fangying Yuan; Jiali Liu; Wan Liu; Jianfang Feng; Yi Jin; Liangxing Tu (AAPS PharmSciTech, 2020)

A Comparative Investigation of the Ability of Various Aptamer-Functionalized Drug Nanocarriers to Induce Selective Apoptosis in Neoplastic Hepatocytes: In Vitro and In Vivo Outcome - Samrat Chakraborty; Zewdu Yilma Dlie; Biswajit Mukherjee; Shila Elizabeth Besra; Soma Sengupta; Ramkrishna Sen; Alankar Mukherjee (AAPS PharmSciTech, 2020)

Permeation-Enhancing Nanoparticle Formulation to Enable Oral Absorption of Enoxaparin - Nermin E. Eleraky; Nitin K. Swarnakar; Dina F. Mohamed; Mohamed A. Attia; Giovanni M. Pauletti (AAPS PharmSciTech, 2020)

Effect of Formulation Variables and Gamma Sterilization on Transcorneal Permeation and Stability of Proniosomal Gels as Ocular Platforms for Antiglaucomal Drug - Sinar Sayed; Mostafa Abdelmoteleb; Maha M. Amin; Omnia M. Khowessah (AAPS PharmSciTech, 2020)

Physical Barrier Type Abuse-Deterrent Formulations: Mechanistic Understanding of Sintering-Induced Microstructural Changes in Polyethylene Oxide Placebo Tablets - Heather J. Boyce; Vivek S. Dave; Myke Scoggins; Vadim J. Gurvich; Daniel T. Smith; Stephen R. Byrn; Stephen W. Hoag (AAPS PharmSciTech, 2020)

Preparation and Characterization of PLGA–PEG–PLGA Nanoparticles Containing Salidroside and Tamoxifen for Breast Cancer Therapy - Xuan Yu; Lili Sun; Lejun Tan; Meng Wang; Xiaoliang Ren; Jiaxin Pi; Miaomiao Jiang; Nan Li (AAPS PharmSciTech, 2020)

Transdermal Administration of Ibuprofen-Loaded Gel: Preparation, Pharmacokinetic Profile, and Tissue Distribution - Meng-qiu Xia; Chun-ling Tian; Liu Liu; Rong-feng Hu; Shuang-ying Gui; Xiao-qin Chu (AAPS PharmSciTech, 2020)

Biorelevant In Vitro Release Testing and In Vivo Study of Extended-Release Niacin Hydrophilic Matrix Tablets - Bartłomiej Milanowski; Arkadiusz Hejduk; Marek A. Bawiec; Emilia Jakubowska; Agnieszka Urbańska; Anna Wiśniewska; Grzegorz Garbacz; Janina Lulek (AAPS PharmSciTech, 2020)
Niacin (nicotinic acid, NA) is administered orally as an antihyperlipidemic agent in extended-release (ER) tablets in high doses. Due to rapid absorption and extensive metabolism (non-linear pharmacokinetics), the drug plasma levels are highly variable, which may correlate with side effects. Interestingly, this erratic drug delivery behavior of niacin ER products cannot be clarified by compendial in vitro release testing. The standard dissolution tests do not allow to mimic the selected GI tract characteristics in order to estimate the robustness of formulation under the variability of the physiological conditions. These are characterized by the pH value, impact of motility forces and composition, as well as volume of GI liquids. Our paper demonstrates a comparison of a newly developed ER HPMC niacin formulation with an originator product. The research aimed to design a robust matrix tablet of comparable biopharmaceutical behavior, safety and efficacy. The extensive in vitro investigation, including dynamic studies in flow-through cell apparatus and stress test device, forms the basis for the evaluation of nicotinic acid plasma concentrations in vivo . The occurrence of erratic, multiple NA plasma peaks after the administration of both extended-release products is a result of its local input excess over the metabolic threshold (at the level corresponding to maximum 2% of the administered dose, i.e., 20 mg of drug) due to the mechanical stresses of physiological intensity. We demonstrate how this behavior is similar for both marketed and test products. In this context, we describe how a robust ER matrix and well-designed formulation does not guarantee the test product’s bioequivalence to the comparator one out of reasons unrelated to technology and biopharmaceutical properties, but because of the active compound’s intrinsic pharmacokinetic characteristics, i.e . , highly variable, extensive metabolism of nicotinic acid.

An Efficient and Cost-Effective Nose-Only Inhalational Chamber for Rodents: Design, Optimization and Validation - Ranjot Kaur; Anupama Kaushik; Kamalinder K. Singh; O. P. Katare; Bhupinder Singh (AAPS PharmSciTech, 2020)

Cardioprotective Efficacy of Silymarin Liquisolid in Isoproterenol Prompted Myocardial Infarction in Rats - Nermin M. Sheta; Yasmin A. Elfeky; Sylvia A. Boshra (AAPS PharmSciTech, 2020)

Study of Top-down and Bottom-up Approaches by Using Design of Experiment (DoE) to Produce Meloxicam Nanocrystal Capsules - Tao Liu; Xinxin Yu; Haipeng Yin (AAPS PharmSciTech, 2020)

Bromocriptine Nanoemulsion-Loaded Transdermal Gel: Optimization Using Factorial Design, In Vitro and In Vivo Evaluation - Sita V G; Pradeep Vavia (AAPS PharmSciTech, 2020)

Effect of a Solid Lipid Nanoparticle Formulation on the Bioavailability of 4-(N)-Docosahexaenoyl 2′, 2′-Difluorodeoxycytidine After Oral Administration - Solange A. Valdes; Riyad F. Alzhrani; Dharmika S. P. Lansakara-P; Zhengrong Cui (AAPS PharmSciTech, 2020)

Poly(L-Glutamic Acid)-Based Brush Copolymers: Fabrication, Self-assembly, and Evaluation as Efficient Nanocarriers for Cationic Protein Drug Delivery - Xin Li; Chao Lu; Wenquan Xia; Guilan Quan; Ying Huang; Xuequn Bai; Feiyuan Yu; Qian Xu; Wanbing Qin; Daojun Liu; Xin Pan (AAPS PharmSciTech, 2020)

Stimuli Responsive In Situ Gelling Systems Loaded with PLGA Nanoparticles of Moxifloxacin Hydrochloride for Effective Treatment of Periodontitis - Sarwar Beg; Shashi Dhiman; Teenu Sharma; Ashish Jain; Rakesh Kumar Sharma; Atul Jain; Bhupinder Singh (AAPS PharmSciTech, 2020)

Aprepitant Intravenous Emulsion Based on Ion Pairing/Phospholipid Complex for Improving Physical and Chemical Stability During Thermal Sterilization - Xinyu Zhang; Ying Wei; Zhijun Cao; Ying Xu; Cong Lu; Meiqi Zhao; Jingxin Gou; Tian Yin; Yu Zhang; Haibing He; Yanjiao Wang; Xing Tang (AAPS PharmSciTech, 2020)

Anti-angiogenesis by dual action of R5K peptide conjugated itraconazole nanoparticles - Chuda Chittasupho; Kantalada Kengtrong; Supawan Chalermnithiwong; Narong Sarisuta (AAPS PharmSciTech, 2020)

Retraction Note: Study of the Transformations of Micro/Nano-crystalline Acetaminophen Polymorphs in Drug-Polymer Binary Mixtures - Mohammed Maniruzzaman; Matthew Lam; Carlos Molina; Ali Nokhodchi (AAPS PharmSciTech, 2020)

Application and Impact of Human Dose Projection from Discovery to Early Drug Development - Dipal Patel; Wenzhan Yang; Maya Lipert; Tian Wu (AAPS PharmSciTech, 2020)

Determining the Sources of Variance in the Preparation of Analytical Standards for Chromatographic Analysis of a Lyophilized Peptide Drug Substance by Nested ANOVA Statistical Analysis - Paul L. Walsh; John Lena; Jennifer Drake; David Lavrich (AAPS PharmSciTech, 2020)

Thermosensitive Hydrogel Based on Poly(2-Ethyl-2-Oxazoline)–Poly(D,L-Lactide)–Poly(2-Ethyl-2-Oxazoline) for Sustained Salmon Calcitonin Delivery - Xiaoning Wang; Yang Wang; Mengru Yan; Xiaoyan Liang; Ning Zhao; Yuantao Ma; Yingchun Gao (AAPS PharmSciTech, 2020)

Liquisolid Pellets and Liqui-Pellets Are Not Different - Bianca Ramos Pezzini; André O’Reilly Beringhs; Humberto Gomes Ferraz; Marcos Antônio Segatto Silva; Hellen Karine Stulzer; Diva Sonaglio (AAPS PharmSciTech, 2020)

Brinzolamide Dimethyl Sulfoxide In Situ Gelling Ophthalmic Solution: Formulation Optimisation and In Vitro and In Vivo Evaluation - Hemant Bhalerao; K.B. Koteshwara; Sajeev Chandran (AAPS PharmSciTech, 2020)

Fabrication and Characterization of Thiolated Chitosan Microneedle Patch for Transdermal Delivery of Tacrolimus - Zulcaif Ahmad; Muhammad Imran Khan; Muhammad Irfan Siddique; Hafiz Shoaib Sarwar; Gul Shahnaz; Syed Zajif Hussain; Nadeem Irfan Bukhari; Irshad Hussain; Muhammad Farhan Sohail (AAPS PharmSciTech, 2020)

Mechanistic Insights of Formulation Approaches for the Treatment of Nail Infection: Conventional and Novel Drug Delivery Approaches - Agrawal Vikas; Patel Rashmin; Patel Mrunali; Rahul B. Chavan; Thanki Kaushik (AAPS PharmSciTech, 2020)

Preparation of Ergosterol-Loaded Nanostructured Lipid Carriers for Enhancing Oral Bioavailability and Antidiabetic Nephropathy Effects - Zhonghua Dong; Sajid Iqbal; Zhongxi Zhao (AAPS PharmSciTech, 2020)

Nanomedicines and Nanosimilars: Looking for a New and Dynamic Regulatory “Astrolabe” Inspired System - Costas Demetzos; Paraskevi Kavatzikidou; Natassa Pippa; Emmanuel Stratakis (AAPS PharmSciTech, 2020)

Development and Characterization of PCL Electrospun Membrane-Coated Bletilla striata Polysaccharide-Based Gastroretentive Drug Delivery System - Zhouying Li; Rui Zeng; Ling Yang; Xiaodong Ren; Katherine G. Maffucci; Yan Qu (AAPS PharmSciTech, 2020)

Preparation and Characterization of Honokiol Nanosuspensions and Preliminary Evaluation of Anti-Inflammatory Effect - Xinyue Lu; Xiaoyu Lu; Zhenhai Zhang; Huixia Lv (AAPS PharmSciTech, 2020)

Development and Investigation of Vitamin C-Enriched Adapalene-Loaded Transfersome Gel: a Collegial Approach for the Treatment of Acne Vulgaris - Sandhya Vasanth; Akhilesh Dubey; Ravi G.S.; Shaila A. Lewis; Vivek M. Ghate; Sally A. El-Zahaby; Srinivas Hebbar (AAPS PharmSciTech, 2020)

Development and Characterization of Bioadhesive Film Embedded with Lignocaine and Calcium Fluoride Nanoparticles - Hira Ghafar; Muhammad Imran Khan; Hafiz Shoaib Sarwar; Samiya Yaqoob; Syed Zajif Hussain; Imran Tariq; Asad Ullah Madni; Gul Shahnaz; Muhammad Farhan Sohail (AAPS PharmSciTech, 2020)

Development of a Two-Compartment System In vitro Dissolution Test and Correlation with In vivo Pharmacokinetic Studies for Celecoxib - Shan Jiang; Guoqing Zhang; Lei Wang; Ye Zeng; Wenjie Liu; Zeneng Cheng (AAPS PharmSciTech, 2020)

In Vivo Evaluation of a Novel Chitosan-Polycaprolactone Based Mucoadhesive Gastro-Retentive Sustained Release Drug Delivery System for Milnacipran HCl - Talib Hussain; Muhammad Ijaz; Rahat Shamim; Khalid Hussain; Nasir Abbas; Amjad Hussain; Julia Anita Griessinger; Nadeem Irfan Bukhari (AAPS PharmSciTech, 2020)

Liposome-Encapsulated Zoledronate Favors Tumor Vascular Normalization and Enhances Anticancer Efficacy of Cisplatin - Xin-jun Cai; Wei-dong Fei; Ying-ying Xu; Hong Xu; Gao-yi Yang; Jia-wei Cao; Jian-jun Ni; Kaiyi Tao; Zeng Wang (AAPS PharmSciTech, 2020)

Is “Slow Inhalation” Always Suitable for Pressurized Metered Dose Inhaler? - Daiki Hira; Tomoyuki Okuda; Ayano Mizutani; Nao Tomida; Megumi Mizuno; Satoshi Ueshima; Mikio Kakumoto; Tomonobu Okano; Hirokazu Okamoto (AAPS PharmSciTech, 2020)

Percutaneous Delivery of Antihypertensive Agents: Advances and Challenges - Kevin Ita; Sharon Ashong (AAPS PharmSciTech, 2020)

Effect of Sodium Alginate Type on Drug Release from Chitosan-Sodium Alginate–Based In Situ Film-Forming Tablets - Liwei JIN; Huangyun Qi; Xiangqin Gu; Xiaofei Zhang; Yeli ZHANG; Xin Zhang; Shirui Mao (AAPS PharmSciTech, 2020)

Anti-HPV Nanoemulsified-Imiquimod: A New and Potent Formulation to Treat Cervical Cancer - Luiza Abrahão Frank; R. P. Gazzi; P. A. Mello; P. Chaves; F. Peña; R. C. R. Beck; A. Buffon; A. R. Pohlmann; Silvia S. Guterres (AAPS PharmSciTech, 2020)

Kaempferia parviflora Nanosuspension Formulation for Scalability and Improvement of Dissolution Profiles and Intestinal Absorption - Catheleeya Mekjaruskul; Bungorn Sripanidkulchai (AAPS PharmSciTech, 2020)

Treatment of Basal Cell Carcinoma Via Binary Ethosomes of Vismodegib: In Vitro and In Vivo Studies - Amr Gamal F; Ossama M. Sayed; Fatma I. Abo El-Ela; Rasha M. Kharshoum; Heba F. Salem (AAPS PharmSciTech, 2020)

Role of Omega-3 Fatty Acids and Butter Oil in Targeting Delivery of Donepezil Hydrochloride Microemulsion to Brain via the Intranasal Route: a Comparative Study - Dignesh Khunt; Meenakshee Shrivas; Suryanarayana Polaka; Piyush Gondaliya; Manju Misra (AAPS PharmSciTech, 2020)

Encapsulation of Red Propolis in Polymer Nanoparticles for the Destruction of Pathogenic Biofilms - Isabelle Souza de Mélo Silva; Livia Maria do Amorim Costa Gaspar; Adriely Maria Oliveira Rocha; Luiz Pereira da Costa; Dayane Batista Tada; Elton Franceschi; Francine Ferreira Padilha (AAPS PharmSciTech, 2020)

Formulation of Ketoconazole Nanocrystal-Based Cryopellets - Antoine Touzet; François Pfefferlé; Alf Lamprecht; Yann Pellequer (AAPS PharmSciTech, 2020)

The Significance of Utilizing In Vitro Transfer Model and Media Selection to Study the Dissolution Performance of Weak Ionizable Bases: Investigation Using Saquinavir as a Model Drug - Mohith Chegireddy; Geeta K. Hanegave; Dani Lakshman; Aman Urazov; K. Navya Sree; Shaila A. Lewis; Swapnil J. Dengale (AAPS PharmSciTech, 2020)

Application of Factorial Design and Rheology to the Development of Photoprotective Formulations - V. T. P. Ferreira; V. H. P. Infante; E. C. Felippim; P. M. B. G. Maia Campos (AAPS PharmSciTech, 2020)

Guar Gum Micro-particles for Targeted Co-delivery of Doxorubicin and Metformin HCL for Improved Specificity and Efficacy Against Colon Cancer: In Vitro and In Vivo Studies - Rajveer Kaur Kang; Neeraj Mishr; Vineet Kumar Rai (AAPS PharmSciTech, 2020)

Mesoporous Carbon Nanoparticles as Multi-functional Carriers for Cancer Therapy Compared with Mesoporous Silica Nanoparticles - Meiting Zhou; Qinfu Zhao; Yifan Wu; Shuang Feng; Da Wang; Ying Zhang; Siling Wang (AAPS PharmSciTech, 2020)

Development and Evaluation of Controlled and Simultaneous Release of Compound Danshen Based on a Novel Colon-Specific Osmotic Pump Capsule - Xiangjiang Nie; Bin Wang; Rongfeng Hu; Wenjie Lu; Jiayi Chen; Songlin Liu; Dong Jin; Chaojie Sun; Song Gao; Yuxing Guo; Wenyou Fang; Haiping Hao (AAPS PharmSciTech, 2020)

A Novel Acetaminophen Soft-Chew Formulation Produced via Hot-Melt Extrusion with In-line Near-Infrared Monitoring as a Process Analytical Technology Tool - Pengchong Xu; Jiaxiang Zhang; Suresh Bandari; Michael A. Repka (AAPS PharmSciTech, 2020)

Assessing Drug Release from Manipulated Abuse Deterrent Formulations - Xin Feng; Ahmed Zidan; Nahid S. Kamal; Xiaoming Xu; Dajun Sun; Ross Walenga; Heather Boyce; Celia N. Cruz; Muhammad Ashraf (AAPS PharmSciTech, 2020)

Orodispersible Carbamazepine/Hydroxypropyl-β-Cyclodextrin Tablets Obtained by Direct Compression with Five-in-One Co-processed Excipients - Jaime Conceição; Oluwatomide Adeoye; Helena Cabral-Marques; Angel Concheiro; Carmen Alvarez-Lorenzo; José Manuel Sousa Lobo (AAPS PharmSciTech, 2020)

Development of Chitosan-Based Hydrogel Containing Antibiofilm Agents for the Treatment of Staphylococcus aureus–Infected Burn Wound in Mice - Tanya Chhibber; Vijay Singh Gondil; V. R. Sinha (AAPS PharmSciTech, 2020)

Enhanced Physical Stability and Synchronized Release of Febuxostat and Indomethacin in Coamorphous Solids - Sakib M. Moinuddin; Qin Shi; Jun Tao; Minshan Guo; Jie Zhang; Qian Xue; Sida Ruan; Ting Cai (AAPS PharmSciTech, 2020)

Optimization, in-vitro Release and in-vivo Evaluation of Gliquidone Nanoparticles - Mohamed S. Mohamed; Wael A. Abdelhafez; Gamal Zayed; Ahmed M. Samy (AAPS PharmSciTech, 2020)

Systematic Optimization, In Vitro Drug Release, and Preliminary Nonclinical Toxicity Assessment of Nonphospholipid-Based Topical Ophthalmic Emulsions Containing 0.05 or 0.1% w/w Cyclosporin A for Dry-Eye Syndrome Management - Syed Nazrin Ruhina Rahman; Datta Maroti Pawde; Oly Katari; Victor Hmingthansanga; Tamilvanan Shunmugaperumal (AAPS PharmSciTech, 2020)

Development of Methotrexate and Minocycline-Loaded Nanoparticles for the Effective Treatment of Rheumatoid Arthritis - Kumar Janakiraman; Venkateshwaran Krishnaswami; Vaidevi Sethuraman; Subramanian Natesan; Vijaya Rajendran; Ruckmani Kandasamy (AAPS PharmSciTech, 2020)

RETRACTED ARTICLE: Bimatoprost Imprinted Silicone Contact Lens to Treat Glaucoma - Feng Yan; Yanxia Liu; Shulan Han; Qingsong Zhao; Nannan Liu (AAPS PharmSciTech, 2020)

Fibrillated Cellulose via High Pressure Homogenization: Analysis and Application for Orodispersible Films - Vincent Lenhart; Julian Quodbach; Peter Kleinebudde (AAPS PharmSciTech, 2020)

Amazonia Products in Novel Lipid Nanoparticles for Fucoxanthin Encapsulation - Leticia Malgarim Cordenonsi; Andressa Santer; Rafaela Martins Sponchiado; Nathalie Ribeiro Wingert; Renata Platcheck Raffin; Elfrides Eva Scherman Schapoval (AAPS PharmSciTech, 2020)

Formulation and Characterization of Nanosized Ethosomal Formulations of Antigout Model Drug (Febuxostat) Prepared by Cold Method: In Vitro/Ex Vivo and In Vivo Assessment - Ahmed A. El-Shenawy; Wael A. Abdelhafez; Ahmed Ismail; Alaa A. Kassem (AAPS PharmSciTech, 2020)

Polyethylene Oxide (PEO) Molecular Weight Effects on Abuse-Deterrent Properties of Matrix Tablets - Saikishore Meruva; Maureen D. Donovan (AAPS PharmSciTech, 2020)

Sustained Release Ziprasidone Microparticles Prepared by Spray Drying with Soluplus® and Ethyl Cellulose to Eliminate Food Effect and Enhance Bioavailability - Wenjie Liu; Shanshan Wang; Wangxing Lu; Zeneng Cheng; Niyanhan Jiang (AAPS PharmSciTech, 2020)

Approaches for Delivery of Drugs Topically - S. Narasimha Murthy (AAPS PharmSciTech, 2020)

Correction to: Development and Assessment of Lipidic Nanoemulsions Containing Sodium Hyaluronate and Indomethacin - Ibtissem Guermech; Mohamed Ali Lassoued; Amal Abdelhamid; Souad Sfar (AAPS PharmSciTech, 2020)

Commentary: Considerations in the Measurement of Glass Transition Temperatures of Pharmaceutical Amorphous Solids - Ann Newman; George Zografi (AAPS PharmSciTech, 2020)
An increased interest in using amorphous solid forms in pharmaceutical applications to increase solubility, dissolution, and bioavailability has generated a need for better characterization of key properties, such as the glass transition ( T g ) temperature. Although many laboratories measure and report this value, the details around these measurements are often vague or misunderstood. In this article, we attempt to highlight and compare various aspects of the two most common methods used to measure pharmaceutical T g values, conventional and modulated differential scanning calorimetry (DSC). Issues that directly impact the T g , such as instrumental parameters, sample preparation methods, data analysis, and “wet” vs. “dry” measurements, are discussed.

HPMC/PVP Dissolving Microneedles: a Promising Delivery Platform to Promote Trans-Epidermal Delivery of Alpha-Arbutin for Skin Lightening - Nway Nway Aung; Tanasait Ngawhirunpat; Theerasak Rojanarata; Prasopchai Patrojanasophon; Praneet Opanasopit; Boonnada Pamornpathomkul (AAPS PharmSciTech, 2020)

Effect of Glucosamine Conjugate-Functionalized Liposomes on Glioma Cell and Healthy Brain: An Insight for Future Application in Brain Infusion - Nisha Yadav; Jacinth Rajendra; Anagha Acharekar; Shilpee Dutt; Pradeep Vavia (AAPS PharmSciTech, 2020)

Transcutol® P/Cremophor® EL/Ethyl Oleate–Formulated Microemulsion Loaded into Hyaluronic Acid–Based Hydrogel for Improved Transdermal Delivery and Biosafety of Ibuprofen - Yongtai Zhang; Kai Zhang; Zhi Wang; Hongmei Hu; Qian Jing; Yanyan Li; Teng Guo; Nianping Feng (AAPS PharmSciTech, 2020)

Chronological Delivery of Antihypertensive Drugs in Bilayered Core-in-Cup Buccoadhesive Tablets: In Vitro and In Vivo Evaluation - Amira A. Rashad; Sara Nageeb El-Helaly; Randa T. Abd El Rehim; Omaima N. El-Gazayerly (AAPS PharmSciTech, 2020)

Metformin Hydrochloride and Sitagliptin Phosphate Fixed-Dose Combination Product Prepared Using Melt Granulation Continuous Processing Technology - Jeremiah F. Kelleher; Atif M. Madi; Gareth C. Gilvary; Y. W. Tian; Shu Li; Ammar Almajaan; Zoe S. Loys; David S. Jones; Gavin P. Andrews; Anne Marie Healy (AAPS PharmSciTech, 2020)

In vitro–In vivo Relationship and Bioequivalence Prediction for Modified-Release Capsules Based on a PBPK Absorption Model - Rebeka Jereb; Jerneja Opara; Igor Legen; Boštjan Petek; Darja Grabnar-Peklar (AAPS PharmSciTech, 2020)

Stable Immune Response Induced by Intradermal DNA Vaccination by a Novel Needleless Pyro-Drive Jet Injector - Chinyang Chang; Jiao Sun; Hiroki Hayashi; Ayano Suzuki; Yuko Sakaguchi; Hiroshi Miyazaki; Tomoyuki Nishikawa; Hironori Nakagami; Kunihiko Yamashita; Yasufumi Kaneda (AAPS PharmSciTech, 2020)
DNA vaccination can be applied to the treatment of various infectious diseases and cancers; however, technical difficulties have hindered the development of an effective delivery method. The efficacy of a DNA vaccine depends on optimal antigen expression by the injected plasmid DNA. The pyro-drive jet injector (PJI) is a novel system that allows for adjustment of injection depth and may, thus, provide a targeted delivery approach for various therapeutic or preventative compounds. Herein, we investigated its potential for use in delivering DNA vaccines. This study evaluated the optimal ignition powder dosage, as well as its delivery effectiveness in both rat and mouse models, while comparing the results of the PJI with that of a needle syringe delivery system. We found that the PJI effectively delivered plasmid DNA to intradermal regions in both rats and mice. Further, it efficiently transfected plasmid DNA directly into the nuclei, resulting in higher protein expression than that achieved via needle syringe injection. Moreover, results from animal ovalbumin (OVA) antigen induction models revealed that animals receiving OVA expression plasmids (pOVA) via PJI exhibited dose-dependent (10 μg, 60 μg, and 120 μg) production of anti-OVA antibodies; while only low titers ( via needle syringe. Thus, PJI is an effective, novel method for delivery of plasmid DNA into epidermal and dermal cells suggesting its promise as a tool for DNA vaccination.

Thermal Extrusion 3D Printing for the Fabrication of Puerarin Immediate-Release Tablets - Pingfei Li; Haoyue Jia; Shiming Zhang; Yining Yang; Haowei Sun; Haoyu Wang; Weisan Pan; Fei Yin; Xinggang Yang (AAPS PharmSciTech, 2020)

Application of a Microreactor to Pharmaceutical Manufacturing: Preparation of Amorphous Curcumin Nanoparticles and Controlling the Crystallinity of Curcumin Nanoparticles by Ultrasonic Treatment - Kaeko Araki; Mai Yoshizumi; Shunsuke Kimura; Akiko Tanaka; Daisuke Inoue; Tomoyuki Furubayashi; Toshiyasu Sakane; Masakazu Enomura (AAPS PharmSciTech, 2020)

Potential Active Targeting of Gatifloxacin to Macrophages by Means of Surface-Modified PLGA Microparticles Destined to Treat Tuberculosis - Patricia Marcianes; Sofia Negro; Emilia Barcia; Consuelo Montejo; Ana Fernández-Carballido (AAPS PharmSciTech, 2020)

Improving the Dissolution of Triclabendazole from Stable Crystalline Solid Dispersions Formulated for Oral Delivery - Daniel Real; Lucas Orzan; Darío Leonardi; Claudio J. Salomon (AAPS PharmSciTech, 2020)

QbD Approach for Novel Crosslinker-Free Ionotropic Gelation of Risedronate Sodium–Chitosan Nebulizable Microspheres: Optimization and Characterization - Omar A. Elkady; Mina Ibrahim Tadros; Hanan M. El-laithy (AAPS PharmSciTech, 2020)

Transdermal Microneedles—A Materials Perspective - R. Ali; P. Mehta; MS Arshad; I. Kucuk; M-W Chang; Z. Ahmad (AAPS PharmSciTech, 2020)

Mannose-Modified PLGA Nanoparticles for Sustained and Targeted Delivery in Hepatitis B Virus Immunoprophylaxis - Jiahuan Zhu; Fuhua Qin; Zhonghua Ji; Weidong Fei; Zeng Tan; Ying Hu; Caihong Zheng (AAPS PharmSciTech, 2020)

Synthesis, Characterization, and Drug Delivery Application of Self-assembling Amphiphilic Cyclodextrin - Mayank R. Patel; Dimitrios A. Lamprou; Pradeep R. Vavia (AAPS PharmSciTech, 2020)

Implication of Coformer Structural Diversity on Cocrystallization Outcomes of Telmisartan with Improved Biopharmaceutical Performance - Jamshed Haneef; Poonam Arora; Renu Chadha (AAPS PharmSciTech, 2020)

Fipronil Tablets: Development and Pharmacokinetic Profile in Beagle Dogs - Gabriela Carmelinda Martins dos Santos; Luiz Henrique Guerreiro Rosado; Melina Cardilo Campos Alves; Isabela de Paula Lima; Thais Paes Ferreira; Debora Azevedo Borges; Priscila Cardim de Oliveira; Viviane de Sousa Magalhães; Fabio Barbour Scott; Yara Peluso Cid (AAPS PharmSciTech, 2020)

The Influence of Matrix Technology on the Subdivision of Sustained Release Matrix Tablets - Maira T. Teixeira; Livia Lira Sa-Barreto; Stephânia F. Taveira; Tais Gratieri; Guilherme M. Gelfuso; Ricardo N. Marreto; Izabel C. Silva; Marcilio Cunha-Filho (AAPS PharmSciTech, 2020)

Distribution of benzalkonium chloride into the aqueous phases of submicron dispersed systems: emulsions, aqueous lecithin dispersion and nanospheres - Dorota Watrobska–Swietlikowska (AAPS PharmSciTech, 2020)
Partitioning of benzalkonium chloride (BAC) into the aqueous phases of submicron dispersed systems such as submicron emulsions, aqueous lecithin dispersion (WLD), and suspension of nanospheres (NLC) was studied. The aqueous phases of the investigated systems were obtained by ultracentrifugation and subsequently were subjected to ultrafiltration, which procedure allowed distinguishing between the fractions of free benzalkonium chloride ( w ) and those incorporated in the liposomal and micellar region ( wlm ). The fractions present in the oily phase and in the interphase of submicron emulsions were calculated. Despite the various composition of the investigated formulations and the initial concentration of BAC, w values were very small at 0.2–8.0%. The wlm value in submicron emulsions was increased by increasing the total concentration of preservative from 29.0 to 42.0%. Using polysorbate 80 instead of lecithin resulted in a distribution of BAC to aqueous–liposomal–micellar phase that was twice as high. The very low concentration of antimicrobial active form of benzalkonium chloride was analyzed in the aqueous phase of emulsions stabilized with lecithin as well as in aqueous lecithin dispersion and nanospheres (below 3%). Replacement of lecithin with polysorbate 80 in emulsions with polysorbate significantly increase (up to 8%) the fraction of benzalkonium chloride in the aqueous phase where microbial growth occurs.

Preparation and In vitro Evaluation of FDM 3D-Printed Ellipsoid-Shaped Gastric Floating Tablets with Low Infill Percentages - Di Chen; Xiang-Yu Xu; Rui Li; Gen-Ao Zang; Yue Zhang; Ming-Rui Wang; Meng-Fei Xiong; Jia-Rui Xu; Ting Wang; Hui Fu; Qin Hu; Bin Wu; et al. (AAPS PharmSciTech, 2020)

Synthesis, Formulation, and Characterization of Doxorubicin-Loaded Laponite/Oligomeric Hyaluronic Acid-Aminophenylboronic Acid Nanohybrids and Cytological Evaluation against MCF-7 Breast Cancer Cells - Yue Yang; Jinyu Li; Fen Chen; Sen Qiao; Yunjian Li; Weisan Pan (AAPS PharmSciTech, 2020)

Probing the Role of Ion-Pair Strategy in Controlling Dexmedetomidine Penetrate Through Drug-in-Adhesive Patch: Mechanistic Insights Based on Release and Percutaneous Absorption Process - Haiying Wang; Qi Tian; Peng Quan; Chao Liu; Liang Fang (AAPS PharmSciTech, 2020)

Formulation of Direct Compression Zidovudine Tablets to Correlate the SeDeM Diagram Expert System and the Rotary Press Simulator Styl’ONE Results - Isaac Nofrerias; Anna Nardi; Marc Suñé-Pou; Josep M. Suñé-Negre; Encarna García-Montoya; Pilar Pérez-Lozano; Montserrat Miñarro; Bernard Bataille; Josep R. Ticó (AAPS PharmSciTech, 2020)

Wurster Fluidised Bed Coating of Microparticles: Towards Scalable Production of Oral Sustained-Release Liquid Medicines for Patients with Swallowing Difficulties - Valentyn Mohylyuk; Kavil Patel; Nathan Scott; Craig Richardson; Darragh Murnane; Fang Liu (AAPS PharmSciTech, 2020)
Suspension of microparticles in an easy-to-swallow liquid is one approach to develop sustained-release formulations for children and patients with swallowing difficulties. However, to date production of sustained-release microparticles at the industrial scale has proven to be challenging. The aim of this investigation was to develop an innovative concept in coating sustained-release microparticles using industrial scalable Wurster fluidised bed to produce oral liquid suspensions. Microcrystalline cellulose cores (particle size w /w) of dry powder glidant, magnesium stearate, to the coating chamber via an external port was applied throughout the coating process. This method significantly increased coating production yield from less than 50% to up to 99% compared to conventional coating process without the dry powder glidant. Powder rheology tests showed that dry powder glidants increased the tapped density and decreased the cohesive index of coated microparticles. Reproducible microencapsulation of a highly water-soluble drug, metoprolol succinate, was achieved, yielding coated microparticles less than 200 μm in size with 20-h sustained drug release, suitable for use in liquid suspensions. The robust, scalable technology presented in this study offers an important solution to the long-standing challenges of formulating sustained-release dosage forms suitable for children and older people with swallowing difficulties.

Mechanical Characterization of Thermally Annealed Tablets Containing Polyethylene Oxide for Abuse Deterrence - Elizabeth Tocce; Matthew Bishop; Karen Balwinski; Tom Watson; Mike Lapham; Kathryn Hewlett; Alexis Wontorcik (AAPS PharmSciTech, 2020)

A Rundown Through Various Methods Used in the Formulation of Solid Self-Emulsifying Drug Delivery Systems (S-SEDDS) - Sharel Rency D. Almeida; Vamshi Krishna Tippavajhala (AAPS PharmSciTech, 2019)

Application of Failure Mode Effect Analysis in Wurster-Based Pelletization Technology: a Technical Note - Aarti Patel; Asha Patel; Rakesh Patel; Abhay Dharamsi (AAPS PharmSciTech, 2019)

Unmet Quality Needs in Oral Drug Delivery: Contrasts of Drug Content and Uniformity on Distinct Approaches for Achieving Individual Dosing - Jaqueline Kalleian Eserian; Márcia Lombardo; Jair Ribeiro Chagas; José Carlos Fernandes Galduróz (AAPS PharmSciTech, 2019)

Utility of Films to Anticipate Effect of Drug Load and Polymer on Dissolution Performance from Tablets of Amorphous Itraconazole Spray-Dried Dispersions - Moshe Honick; Kanika Sarpal; Alaadin Alayoubi; Ahmed Zidan; Stephen W. Hoag; Robert G. Hollenbeck; Eric J. Munson; James E. Polli (AAPS PharmSciTech, 2019)

Development and Assessment of Lipidic Nanoemulsions Containing Sodium Hyaluronate and Indomethacin - Ibtissem Guermech; Mohamed Ali Lassoued; Amal Abdelhamid; Souad Sfar (AAPS PharmSciTech, 2019)

Optimizing Aerosolization Using Computational Fluid Dynamics in a Pediatric Air-Jet Dry Powder Inhaler - Karl Bass; Dale Farkas; Worth Longest (AAPS PharmSciTech, 2019)

LyoPRONTO: an Open-Source Lyophilization Process Optimization Tool - Gayathri Shivkumar; Petr S. Kazarin; Andrew D. Strongrich; Alina A. Alexeenko (AAPS PharmSciTech, 2019)
This work presents a new user-friendly lyophilization simulation and process optimization tool, freely available under the name LyoPRONTO. This tool comprises freezing and primary drying calculators, a design-space generator, and a primary drying optimizer. The freezing calculator performs 0D lumped capacitance modeling to predict the product temperature variation with time which shows reasonably good agreement with experimental measurements. The primary drying calculator performs 1D heat and mass transfer analysis in a vial and predicts the drying time with an average deviation of 3% from experiments. The calculator is also extended to generate a design space over a range of chamber pressures and shelf temperatures to predict the most optimal setpoints for operation. This optimal setpoint varies with time due to the continuously varying product resistance and is taken into account by the optimizer which provides varying chamber pressure and shelf temperature profiles as a function of time to minimize the primary drying time and thereby, the operational cost. The optimization results in 62% faster primary drying for 5% mannitol and 50% faster primary drying for 5% sucrose solutions when compared with typical cycle conditions. This optimization paves the way for the design of the next generation of lyophilizers which when coupled with accurate sensor networks and control systems can result in self-driving freeze dryers.

Human Serum Albumin, a Suitable Candidate to Stabilize Freeze-Dried IgG in Combination with Trehalose: Central Composite Design - Maedeh Shams Nouraei; Homa Faghihi; Abdolhossein Roulholamini Najafabadi; Amir Hossein Mohammad Zadeh; Majid Darabi; Alireza Vatanara (AAPS PharmSciTech, 2019)

Formulation and Evaluation of Novel Thiolated Intra Pocket Periodontal Composite Membrane of Doxycycline - Asma Kanwal; Ali Iqbal; Rabia Arshad; Sohail Akhtar; Sobia Razzaq; Nasir Mahmood Ahmad; Hina Naz; Gul Shahnaz (AAPS PharmSciTech, 2019)

Fabrication of Ibrutinib Nanosuspension by Quality by Design Approach: Intended for Enhanced Oral Bioavailability and Diminished Fast Fed Variability - Nagarjun Rangaraj; Sravanthi Reddy Pailla; Paramesh Chowta; Sunitha Sampathi (AAPS PharmSciTech, 2019)

Controlled Release of Lidocaine–Diclofenac Ionic Liquid Drug from Freeze-Thawed Gelatin/Poly(Vinyl Alcohol) Transdermal Patches - Pattwat Maneewattanapinyo; Alisa Yeesamun; Fueangfah Watthana; Kamon Panrat; Wiwat Pichayakorn; Jirapornchai Suksaeree (AAPS PharmSciTech, 2019)

Simultaneous Evaluation of Dissolution and Permeation of Oral Drug Solid Formulations for Predicting Absorption Rate–Limiting Factors and In Vitro–In Vivo Correlations: Case Study Using a Poorly Soluble Weakly Basic Drug - Ziqiang Li; Xin He; Shuang Tian; Guo Feng; Cong Huang; Mingjin Xun; Zengguang Wu; Yangyang Wang (AAPS PharmSciTech, 2019)

Dexamethasone Degradation in Aqueous Medium and Implications for Correction of In Vitro Release from Sustained Release Delivery Systems - Brock Matter; Alireza Ghaffari; David Bourne; Yan Wang; Stephanie Choi; Uday B. Kompella (AAPS PharmSciTech, 2019)

Optimization of Inositol Hexaphosphate Colon Targeted Formulation for Anticarcinogenic Marker Modulation - Nidhi Mishra; Malti Arya; Krishna P. Gupta; Shubhini A. Saraf (AAPS PharmSciTech, 2019)

Orphan Formulations in Pediatric Schistosomiasis Treatment: Development and Characterization of Praziquantel Nanoparticle—Loaded Powders for Reconstitution - M. A. Gonzalez; M. V. Ramírez Rigo; N. L. Gonzalez Vidal (AAPS PharmSciTech, 2019)

Selectivity Enhancement of Paclitaxel Liposome Towards Folate Receptor-Positive Tumor Cells by Ligand Number Optimization Approach - Mahendra Kumar Prajapati; Aniketh Bishnu; Pritha Ray; Pradeep R. Vavia (AAPS PharmSciTech, 2019)

A Lipid Micellar System Loaded with Dexamethasone Palmitate Alleviates Rheumatoid Arthritis - Xinxin Wang; Yan Feng; Jijun Fu; Cuishuan Wu; Bing He; Hua Zhang; Xueqing Wang; Wenbing Dai; Yong Sun; Qiang Zhang (AAPS PharmSciTech, 2019)

Physicochemical Profiling of Baicalin Along with the Development and Characterization of Cyclodextrin Inclusion Complexes - Géza Jakab; Dóra Bogdán; Károly Mazák; Ruth Deme; Zoltán Mucsi; István M. Mándity; Béla Noszál; Nikolett Kállai-Szabó; István Antal (AAPS PharmSciTech, 2019)
Baicalin is a flavone glycoside extracted from Scutellaria baicalensis , a traditional Chinese herbal medicine. Numerous pharmacological effects of baicalin were reported ( e.g. antioxidant, anxiolytic); nevertheless, the most important physicochemical properties influencing the pharmacokinetic behaviour and the concomitant oral bioavailability have not yet been described in a comprehensive study. The aim of this project was to characterize the acid-base, lipophilicity, biorelevant solubility and permeability properties of the drug substance and providing scientific data to support the dosage form design. Another important objective was the comparative evaluation of six various baicalin-cyclodextrin (CD) inclusion complexes along with the creation of a suitable Drug Delivery System (DDS) for this BCS IV drug. Biorelevant profiling was carried out by NMR-pH titrations, saturation shake-flask and distribution coefficients (log P ) measurements, while CD inclusion studies were fulfilled by experimental methods (phase solubility, 1 H/ 13 C NMR, 2D ROESY) and computational approaches. Due to low aqueous solubility (67.03 ± 1.60 μg/ml) and low permeability ( P app = 0.037 × 10 −6 cm/s), baicalin is classified as BCS IV. The γ-CD complexation significantly increased the solubility of baicalin (~ 5 times). The most promoted chemical shift change occurred in baicalin-γ-CD complex. Computational studies showed disparate binding pattern for baicalin in case of β- and γ-CD; furthermore, the calculated complexation energy was − 162.4 kJ mol −1 for β-CD, while it was significantly stronger for γ-CD (− 181.5 kJ mol −1 ). The physicochemical and structural information of baicalin and its CD complexes introduced herein can create molecular basis for a promising DDS with enhanced bioavailability containing a bioactive phytopharmacon.

Product Development, Manufacturing, and Packaging of Solid Dosage Forms Under QbD and PAT Paradigm: DOE Case Studies for Industrial Applications - Brahma N. Singh (AAPS PharmSciTech, 2019)

Development, Optimization, and Evaluation In Vitro/In Vivo of Oral Liquid System for Synchronized Sustained Release of Levodopa/Benserazide - Yang Qu; Wen-Long Lai; Yuan-Rong Xin; Fei-Qin Zhu; Yuan Zhu; Li Wang; Yue-ping Ding; Ying Xu; Hong-Fei Liu (AAPS PharmSciTech, 2019)

Preparation of Filaments and the 3D Printing of Dronedarone HCl Tablets for Treating Cardiac Arrhythmias - Gordana Matijašić; Matija Gretić; Kristina Kezerić; Juraj Petanjek; Ema Vukelić (AAPS PharmSciTech, 2019)

QSPR Modeling of Biopharmaceutical Properties of Hydroxypropyl Methylcellulose (Cellulose Ethers) Tablets Based on Its Degree of Polymerization - Amit J. Kasabe; Ajit S. Kulkarni; Vinod L. Gaikwad (AAPS PharmSciTech, 2019)

A Multiscale Study on the Effect of Sodium Cholate on the Deformation Ability of Elastic Liposomes - Zhimin Wu; Chang Yang; Liping Chen; Lina Ma; Xiaowen Wu; Xingxing Dai; Yanjiang Qiao; Xinyuan Shi (AAPS PharmSciTech, 2019)

A Non-innocent Magnesium Organoclay-Based Drug Vehicle for Improving the Cancer Therapy Effect of Methotrexate - Jinyu Li; Sen Qiao; Guoxin Tan; Yibin Yu; Dandan Liu; Weisan Pan (AAPS PharmSciTech, 2019)

Influenza A(H5N1) Virus Subunit Vaccine Administered with CaPNP Adjuvant Induce High Virus Neutralization Antibody Titers in Mice - Tulin Morcol; Peri Nagappan; Stephen J. D. Bell; Andrew G. Cawthon (AAPS PharmSciTech, 2019)

Whole-Eye Perfusion Model for Screening of the Ocular Formulations via Confocal Laser Scanning Microscopy - Shallu Kutlehria; Arvind Bagde; Nilkumar Patel; Mandip Singh (AAPS PharmSciTech, 2019)

New Perspective Enteric-Coated Tablet Dosage Form for Oral Administration of Ceftriaxone: In Vitro and In Vivo Assessments - Amir E. Maghrabia; Mariza F. Boughdady; Mahasen M. Meshali (AAPS PharmSciTech, 2019)

Enhanced the Bioavailability of Sterile 20(S)-Protopanaxadiol Nanocrystalline Suspension Coated by Bovine Serum Albumin for Intramuscular Injection: In Vitro and In Vivo Evaluation - Hui Zhang; Hongbing Liu; Pan Qi; Silin Wang; Haibin Hu; Jingxin Gou; Yu Zhang; Haibing He; Xing Tang; Tian Yin; Yue Yuan (AAPS PharmSciTech, 2019)

Effects of Drug Particle Size and Lipid Additives on Drug Release from Paraffin Wax Formulations Prepared by Spray Congealing Technique - Hongyi Ouyang; Chen Yee Ang; Paul Wan Sia Heng; Lai Wah Chan (AAPS PharmSciTech, 2019)

Drug Solubilization by Means of Partition/Association Equilibrium Using a Modified Nanosized Dendrimeric Biopolymer - Hwee Jing Ong; Rodolfo Pinal (AAPS PharmSciTech, 2019)

Preparation of Deoxycholate-Modified Docetaxel-Cimetidine Complex Chitosan Nanoparticles to Improve Oral Bioavailability - Yingxin Xu; Tianxu Fang; Yifan Yang; Li’ang Sun; Qi Shen (AAPS PharmSciTech, 2019)

A Nasal Temperature and pH Dual-Responsive In Situ Gel Delivery System Based on Microemulsion of Huperzine A: Formulation, Evaluation, and In Vivo Pharmacokinetic Study - Yifan Chen; Gang Cheng; Rongfeng Hu; Shengqi Chen; Wenjie Lu; Song Gao; Hongmei Xia; Bin Wang; Chaojie Sun; Xiangjiang Nie; Qiang Shen; Wenyou Fang (AAPS PharmSciTech, 2019)

Application of a Thermosensitive In Situ Gel of Chitosan-Based Nasal Spray Loaded with Tranexamic Acid for Localised Treatment of Nasal Wounds - Hanieh Gholizadeh; Elisa Messerotti; Michele Pozzoli; Shaokoon Cheng; Daniela Traini; Paul Young; Agisilaos Kourmatzis; Carla Caramella; Hui Xin Ong (AAPS PharmSciTech, 2019)

Recent Advances in Polymeric Implants - Kawther Khalid Ahmed; Manar Adnan Tamer; Mowafaq Mohammed Ghareeb; Aliasger K. Salem (AAPS PharmSciTech, 2019)

Caproyl-Modified G2 PAMAM Dendrimer (G2-AC) Nanocomplexes Increases the Pulmonary Absorption of Insulin - Chengyun Yan; Jiwei Gu; Yuguang Lv; Weiguo Shi; Yuefeng Wang; Ying Liao; Yueyi Deng (AAPS PharmSciTech, 2019)

Performance of the Population Bioequivalence (PBE) Statistical Test with Impactor Sized Mass Data - Stephanie Chen; Beth Morgan; Hayden Beresford; Elise Burmeister Getz; David Christopher; Göran Långström; Helen Strickland; Christopher Wiggenhorn; Svetlana Lyapustina (AAPS PharmSciTech, 2019)

Preparation, Optimization, and Evaluation of Hyaluronic Acid-Based Hydrogel Loaded with Miconazole Self-Nanoemulsion for the Treatment of Oral Thrush - Khaled M. Hosny; Hibah M. Aldawsari; Rahaf H Bahmdan; Amal M. Sindi; Mallesh Kurakula; Majed M. Alrobaian; Ahmed Y. Aldryhim; Hala M Alkhalidi; Hiba Hisham Bahmdan; Rasha A. Khallaf; Amani M. El Sisi (AAPS PharmSciTech, 2019)

QbD Innovation Through Advances in PAT, Data Analysis Methodologies, and Material Characterization - William C. Stagner; Rahul V. Haware (AAPS PharmSciTech, 2019)

Didodecyldimethylammonium Bromide Role in Anchoring Gold Nanoparticles onto Liposome Surface for Triggering the Drug Release - N. Naitlho; F. Prieto-Dapena; A. M. Rabasco; M. Rueda; María Luisa González-Rodríguez (AAPS PharmSciTech, 2019)

Liver Targeting Albumin-Coated Silybin-Phospholipid Particles Prepared by Nab™ Technology for Improving Treatment Effect of Acute Liver Damage in Intravenous Administration - Cong Lu; Xin Li; Xue Liang; Xinyu Zhang; Tian Yin; Jingxin Gou; Haibing He; Yu Zhang; Xing Tang (AAPS PharmSciTech, 2019)

Development and Characterisation of Gastroretentive Solid Dosage Form Based on Melt Foaming - Gábor Vasvári; Ádám Haimhoffer; László Horváth; István Budai; György Trencsényi; Monika Béresová; Csaba Dobó-Nagy; Judit Váradi; Ildikó Bácskay; Zoltán Ujhelyi; Pálma Fehér; Dávid Sinka; et al. (AAPS PharmSciTech, 2019)

Heat Transfer Evaluation During Twin-Screw Wet Granulation in View of Detailed Process Understanding - Fanny Stauffer; Alexander Ryckaert; Daan Van Hauwermeiren; Adrian Funke; Dejan Djuric; Ingmar Nopens; Thomas De Beer (AAPS PharmSciTech, 2019)

A Novel Self-Assembly Nanocrystal as Lymph Node-Targeting Delivery System: Higher Activity of Lymph Node Targeting and Longer Efficacy Against Lymphatic Metastasis - Yuling Mao; Jun Liu; Tianyu Shi; Ge Chen; Shujun Wang (AAPS PharmSciTech, 2019)

Exploring the Potential of Mesoporous Silica as a Carrier for Puerarin: Characterization, Physical Stability, and In Vivo Pharmacokinetics - Zhi Wang; Bei-Ni Ye; Yong-Tai Zhang; Jian-Xu Xie; Wan-Si Li; Hong-Tao Zhang; Ying Liu; Nian-Ping Feng (AAPS PharmSciTech, 2019)

Nanocrystal Formulation Improves Vaginal Delivery of CSIC for HIV Prevention - Tiantian Gong; Sravan Kumar Patel; Michael A. Parniak; Byron Ballou; Lisa C. Rohan (AAPS PharmSciTech, 2019)

Role of Ceramides in Drug Delivery - Hamad Alrbyawi; Ishwor Poudel; Ranjeet Prasad Dash; Nuggehally R. Srinivas; Amit K Tiwari; Robert D. Arnold; R. Jayachandra Babu (AAPS PharmSciTech, 2019)

Development and Evaluation of Optimized Thiolated Chitosan Proniosomal Gel Containing Duloxetine for Intranasal Delivery - Maryam khatoon; Muhammad Farhan Sohail; Gul Shahnaz; Fiza ur Rehman; Fakhar-ud-Din; Asim ur Rehman; Naseem Ullah; Umair Amin; Gul Majid Khan; Kifayat Ullah Shah (AAPS PharmSciTech, 2019)

Redispersible Spray-Dried Powder Containing Nanoencapsulated Curcumin: the Drying Process Does Not Affect Neuroprotection In vitro - Diego Fontana de Andrade; Branko Vukosavljevic; Juliana Bender Hoppe; Adriana Raffin Pohlmann; Sílvia Stanisçuaski Guterres; Maike Windbergs; Irene Külkamp-Guerreiro; Christianne Gazzana Salbego; Ruy Carlos Ruver Beck (AAPS PharmSciTech, 2019)

Self-Micro-Emulsifying Controlled Release of Eugenol Pellets: Preparation, In vitro/In vivo Investigation in Beagle Dogs - Qilong Wang; Min Guo; Michael Adu-Frimpong; Kangyi Zhang; Qiuxuan Yang; Elmurat Toreniyazov; Hao Ji; Ximing Xu; Xia Cao; Jiangnan Yu (AAPS PharmSciTech, 2019)

A Novel Micron-Size Particulate Formulation of Felodipine with Improved Release and Enhanced Oral Bioavailability Fabricated by Coaxial Electrospray - Xuezhi Yin; Hao Pan; Hongfei Liu (AAPS PharmSciTech, 2019)

Sericin Inhibits Devitrification of Amorphous Drugs - Nitin Salunkhe; Namdeo Jadhav; Harinath More; Prafulla Choudhari (AAPS PharmSciTech, 2019)

Silk Fibroin as a Novel Alcohol-Resistant Excipient for Sustained-Release Tablet Formulation - Jan Kozak; Miloslava Rabiskova; Alf Lamprecht (AAPS PharmSciTech, 2019)

Preparation and Evaluation of mPEG-PLGA Block Copolymer Micelles Loaded with a Sarsasapogenin Derivative - Shu Wang; Mengqi Liu; Wenbao Wang; Ting Li; Mengsuo Cui; Wenliang Sun; Xinggang Yang; Shaojiang Song (AAPS PharmSciTech, 2019)