Variable impact of three different antiangiogenic drugs alone or in combination with chemotherapy on multiple bone marrow-derived cell populations involved in angiogenesis and immunity - Elaine Reguera-Nuñez; Shan Man; Ping Xu; Frank Hilberg; Robert S. Kerbel (Angiogenesis, 2019)

VEGFR2 activation mediates the pro-angiogenic activity of BMP4 - Sara Rezzola; Margherita Di Somma; Michela Corsini; Daria Leali; Cosetta Ravelli; Viviane A. B. Polli; Elisabetta Grillo; Marco Presta; Stefania Mitola (Angiogenesis, 2019)

Adgrf5 contributes to patterning of the endothelial deep layer in retina - C. Niaudet; M. Petkova; B. Jung; S. Lu; B. Laviña; S. Offermanns; C. Brakebusch; C. Betsholtz (Angiogenesis, 2019)

PinX1 represses renal cancer angiogenesis via the mir-125a-3p/VEGF signaling pathway - Pingfu Hou; Hailong Li; Hongmei Yong; Fang Chen; Sufang Chu; Junnian Zheng; Jin Bai (Angiogenesis, 2019)

Successful therapy with bevacizumab combined with corticosteroids for crizotinib-induced interstitial lung disease - Xiaohong Xie; Bingpeng Guo; Xinqing Lin; Yinyin Qin; Ming Ouyang; Shiyue Li; Chengzhi Zhou (Angiogenesis, 2019)

The role of receptor MAS in microglia-driven retinal vascular development - S. Foulquier; V. Caolo; G. Swennen; I. Milanova; S. Reinhold; C. Recarti; N. Alenina; M. Bader; U. M. Steckelings; T. Vanmierlo; M. J. Post; E. A. Jones; et al. (Angiogenesis, 2019)

RETRACTED ARTICLE: Cancer-derived exosomal miR-221-3p promotes angiogenesis by targeting THBS2 in cervical squamous cell carcinoma - Xiang-Guang Wu; Chen-Fei Zhou; Yan-Mei Zhang; Rui-Ming Yan; Wen-Fei Wei; Xiao-Jing Chen; Hong-Yan Yi; Luo-Jiao Liang; Liang-sheng Fan; Li Liang; Sha Wu; Wei Wang (Angiogenesis, 2019)

Cancer stem cells contribute to angiogenesis and lymphangiogenesis in serous adenocarcinoma of the ovary - Syama Krishnapriya; Chirukandath Sidhanth; Pacharla Manasa; Smarakan Sneha; Sadhanandhan Bindhya; Rohit P. Nagare; Balaji Ramachandran; Pushpa Vishwanathan; Kanchan Murhekar; Sundersingh Shirley; Trivadi Sundaram Ganesan (Angiogenesis, 2019)

Monitoring tumour microenvironment changes during anti-angiogenesis therapy using functional MRI - Jianye Liang; Qingqing Cheng; Jiaxi Huang; Mengjie Ma; Dong Zhang; Xueping Lei; Zeyu Xiao; Dongmei Zhang; Changzheng Shi; Liangping Luo (Angiogenesis, 2019)

Prognostic effect of VEGF gene variants in metastatic non-small-cell lung cancer patients - Ivana Sullivan; Pau Riera; Marta Andrés; Albert Altés; Margarita Majem; Remei Blanco; Laia Capdevila; Andrés Barba; Agustí Barnadas; Juliana Salazar (Angiogenesis, 2019)

The plaque-aortic ring assay: a new method to study human atherosclerosis-induced angiogenesis - Alfred C. Aplin; Roberto F. Nicosia (Angiogenesis, 2019)

Exhaustion of the bone marrow progenitor cell reserve is associated with major events in severe limb ischemia - Hendrik Gremmels; Femke C. C. van Rhijn-Brouwer; Diana A. Papazova; Joost O. Fledderus; Martin Teraa; Marianne C. Verhaar (Angiogenesis, 2019)

A new prognostic model for survival in second line for metastatic renal cell carcinoma: development and external validation - Lisa Derosa; Mohamed Amine Bayar; Laurence Albiges; Gwénaël Le Teuff; Bernard Escudier (Angiogenesis, 2019)

Anti-secretogranin III therapy of oxygen-induced retinopathy with optimal safety - Fen Tang; Michelle E. LeBlanc; Weiwen Wang; Dan Liang; Ping Chen; Tsung-Han Chou; Hong Tian; Wei Li (Angiogenesis, 2019)

A ribosomal DNA-hosted microRNA regulates zebrafish embryonic angiogenesis - Yunwei Shi; Xuchu Duan; Guangmin Xu; Xiaoning Wang; Guanyun Wei; Shikui Dong; Gangcai Xie; Dong Liu (Angiogenesis, 2019)

Angiogenic desmoplastic histopathological growth pattern as a prognostic marker of good outcome in patients with colorectal liver metastases - Boris Galjart; Pieter M. H. Nierop; Eric P. van der Stok; Robert R. J. Coebergh van den Braak; Diederik J. Höppener; Sofie Daelemans; Luc Y. Dirix; Cornelis Verhoef; Peter B. Vermeulen; Dirk J. Grünhagen (Angiogenesis, 2019)

Live imaging of angiogenesis during cutaneous wound healing in adult zebrafish - Chikage Noishiki; Shinya Yuge; Koji Ando; Yuki Wakayama; Naoki Mochizuki; Rei Ogawa; Shigetomo Fukuhara (Angiogenesis, 2019)

Interleukin-8 release by endothelial colony-forming cells isolated from idiopathic pulmonary fibrosis patients might contribute to their pathogenicity - Adeline Blandinières; Nicolas Gendron; Nour Bacha; Ivan Bièche; Richard Chocron; Hilario Nunes; Nathalie Nevo; Elisa Rossi; Bruno Crestani; Séverine Lecourt; Sylvie Chevret; Anna Lokajczyk; et al. (Angiogenesis, 2019)

Kruppel-like factor 4 regulates developmental angiogenesis through disruption of the RBP-J–NICD–MAML complex in intron 3 of Dll4 - Evgenii Boriushkin; Hui Zhang; Mitchell Becker; Janet Peachey; Mohammad A. Shatat; Ralf H. Adams; Anne Hamik (Angiogenesis, 2019)

Interleukin-22 promotes tumor angiogenesis - Nicholas J. Protopsaltis; Wei Liang; Eric Nudleman; Napoleone Ferrara (Angiogenesis, 2019)

Mouse models of Alzheimer’s disease cause rarefaction of pial collaterals and increased severity of ischemic stroke - Hua Zhang; Bo Jin; James E. Faber (Angiogenesis, 2019)

TSPYL5-mediated inhibition of p53 promotes human endothelial cell function - Hee-Jun Na; Chung Eun Yeum; Han-Seop Kim; Jungwoon Lee; Jae Yun Kim; Yee Sook Cho (Angiogenesis, 2019)

The regulatory network of miR-141 in the inhibition of angiogenesis - Haojie Dong; Chunhua Weng; Rongpan Bai; Jinghao Sheng; Xiangwei Gao; Ling Li; Zhengping Xu (Angiogenesis, 2019)

ADAM10 controls the differentiation of the coronary arterial endothelium - Gregory Farber; Matthew M. Parks; Nicole Lustgarten Guahmich; Yi Zhang; Sébastien Monette; Scott C. Blanchard; Annarita Di Lorenzo; Carl P. Blobel (Angiogenesis, 2019)

AutoTube: a novel software for the automated morphometric analysis of vascular networks in tissues - Javier A. Montoya-Zegarra; Erica Russo; Peter Runge; Maria Jadhav; Ann-Helen Willrodt; Szymon Stoma; Simon F. Nørrelykke; Michael Detmar; Cornelia Halin (Angiogenesis, 2019)

Pazopanib may reduce bleeding in hereditary hemorrhagic telangiectasia - Marie E. Faughnan; James R. Gossage; Murali M. Chakinala; S. Paul Oh; Raj Kasthuri; Christopher C. W. Hughes; Justin P. McWilliams; Joseph G. Parambil; Nicholas Vozoris; Jill Donaldson; Gitanjali Paul; Pamela Berry; et al. (Angiogenesis, 2019)
Pazopanib (Votrient) is an orally administered tyrosine kinase inhibitor that blocks VEGF receptors potentially serving as anti-angiogenic treatment for hereditary hemorrhagic telangiectasia (HHT). We report a prospective, multi-center, open-label, dose-escalating study [50 mg, 100 mg, 200 mg, and 400 mg], designed as a proof-of-concept study to demonstrate efficacy of pazopanib on HHT-related bleeding, and to measure safety. Patients, recruited at 5 HHT Centers, required ≥ 2 Curacao criteria AND [anemia OR severe epistaxis with iron deficiency]. Co-primary outcomes, hemoglobin (Hgb) and epistaxis severity, were measured during and after treatment, and compared to baseline. Safety monitoring occurred every 1.5 weeks. Seven patients were treated with 50 mg pazopanib daily. Six/seven showed at least 50% decrease in epistaxis duration relative to baseline at some point during study; 3 showed at least 50% decrease in duration during Weeks 11 and 12. Six patients showed a decrease in ESS of > 0.71 (MID) relative to baseline at some point during study; 3/6 showed a sustained improvement. Four patients showed > 2 gm improvement in Hgb relative to baseline at one or more points during study. Health-related QOL scores improved on all SF-36 domains at Week 6 and/or Week 12, except general health (unchanged). There were 19 adverse events (AE) including one severe AE (elevated LFTs, withdrawn from dosing at 43 days); with no serious AE. In conclusion, we observed an improvement in Hgb and/or epistaxis in all treated patients. This occurred at a dose much lower than typically used for oncologic indications, with no serious AE. Further studies of pazopanib efficacy are warranted.

Extracellular vesicles of multiple myeloma cells utilize the proteasome inhibitor mechanism to moderate endothelial angiogenesis - Moran Zarfati; Irit Avivi; Benjamin Brenner; Tami Katz; Anat Aharon (Angiogenesis, 2019)

Platelets: the holy grail in cancer blood biomarker research? - Siamack Sabrkhany; Marijke J. E. Kuijpers; Arjan W. Griffioen; Mirjam G. A. oude Egbrink (Angiogenesis, 2019)

Staphylococcus aureus alpha toxin activates Notch in vascular cells - Sonia L. Hernandez; Mildred Nelson; Georgia R. Sampedro; Naina Bagrodia; Ann M. Defnet; Bianca Lec; Jared Emolo; Rebecca Kirschner; Lydia Wu; Henry Biermann; Stephanie Shen; Juliane Bubeck Wardenburg; et al. (Angiogenesis, 2019)

Excess vascular endothelial growth factor-A disrupts pericyte recruitment during blood vessel formation - Jordan Darden; Laura Beth Payne; Huaning Zhao; John C. Chappell (Angiogenesis, 2019)

Perfused 3D angiogenic sprouting in a high-throughput in vitro platform - V. van Duinen; D. Zhu; C. Ramakers; A. J. van Zonneveld; P. Vulto; T. Hankemeier (Angiogenesis, 2019)

The calcium-binding type III repeats domain of thrombospondin-2 binds to fibroblast growth factor 2 (FGF2) - Marco Rusnati; Patrizia Borsotti; Elisabetta Moroni; Chiara Foglieni; Paola Chiodelli; Laura Carminati; Denise Pinessi; Douglas S. Annis; Giulia Paiardi; Antonella Bugatti; Alessandro Gori; Renato Longhi; et al. (Angiogenesis, 2019)

Understanding the evolving phenotype of vascular complications in telomere biology disorders - Cecilia Higgs; Yanick J. Crow; Denise M. Adams; Emmanuel Chang; Don Hayes; Utz Herbig; James N. Huang; Ryan Himes; Kunal Jajoo; F. Brad Johnson; Susan D. Reynolds; Yoshihiro Yonekawa; et al. (Angiogenesis, 2019)

Angiogenesis in pancreatic cancer: current research status and clinical implications - Shuo Li; Hua-Xiang Xu; Chun-Tao Wu; Wen-Quan Wang; Wei Jin; He-Li Gao; Hao Li; Shi-Rong Zhang; Jin-Zhi Xu; Zi-Hao Qi; Quan-Xing Ni; Xian-Jun Yu; et al. (Angiogenesis, 2019)

Activin receptor-like kinase 1 is associated with immune cell infiltration and regulates CLEC14A transcription in cancer - Matteo Bocci; Jonas Sjölund; Ewa Kurzejamska; David Lindgren; Nour-Al-Dain Marzouka; Michael Bartoschek; Mattias Höglund; Kristian Pietras (Angiogenesis, 2019)

Leptin is a physiological regulator of skeletal muscle angiogenesis and is locally produced by PDGFRα and PDGFRβ expressing perivascular cells - Emmanuel Nwadozi; Andrew Ng; Anna Strömberg; Hsin-yi Liu; Karl Olsson; Thomas Gustafsson; Tara L. Haas (Angiogenesis, 2019)

CMTM4 regulates angiogenesis by promoting cell surface recycling of VE-cadherin to endothelial adherens junctions - Ihsan Chrifi; Laura Louzao-Martinez; Maarten M. Brandt; Christian G. M. van Dijk; Petra E. Bürgisser; Changbin Zhu; Johan M. Kros; Marianne C. Verhaar; Dirk J. Duncker; Caroline Cheng (Angiogenesis, 2019)

The therapeutic potential of targeting the endothelial-to-mesenchymal transition - Shirley Man; Gonzalo Sanchez Duffhues; Peter ten Dijke; David Baker (Angiogenesis, 2019)

Cellular self-assembly into 3D microtissues enhances the angiogenic activity and functional neovascularization capacity of human cardiopoietic stem cells - Petra Wolint; Annina Bopp; Anna Woloszyk; Yinghua Tian; Olivera Evrova; Monika Hilbe; Pietro Giovanoli; Maurizio Calcagni; Simon P. Hoerstrup; Johanna Buschmann; Maximilian Y. Emmert (Angiogenesis, 2019)

Angiogenic capacity in pre-eclampsia and uncomplicated pregnancy estimated by assay of angiogenic proteins and an in vitro vasculogenesis/angiogenesis test - Anita Virtanen; Outi Huttala; Kati Tihtonen; Tarja Toimela; Tuula Heinonen; Jukka Uotila (Angiogenesis, 2019)

Inhibition of macrophage inflammatory protein-1β improves endothelial progenitor cell function and ischemia-induced angiogenesis in diabetes - Ting-Ting Chang; Liang-Yu Lin; Jaw-Wen Chen (Angiogenesis, 2019)

PDGF-BB regulates splitting angiogenesis in skeletal muscle by limiting VEGF-induced endothelial proliferation - R. Gianni-Barrera; A. Butschkau; A. Uccelli; A. Certelli; P. Valente; M. Bartolomeo; E. Groppa; M. G. Burger; R. Hlushchuk; M. Heberer; D. J. Schaefer; L. Gürke; et al. (Angiogenesis, 2018)

EphB4 mediates resistance to antiangiogenic therapy in experimental glioma - Christian Uhl; Moritz Markel; Thomas Broggini; Melina Nieminen; Irina Kremenetskaia; Peter Vajkoczy; Marcus Czabanka (Angiogenesis, 2018)

Fluorescent reporter transgenic mice for in vivo live imaging of angiogenesis and lymphangiogenesis - Susan J. Doh; Michael Yamakawa; Samuel M. Santosa; Mario Montana; Kai Guo; Joseph R. Sauer; Nicholas Curran; Kyu-Yeon Han; Charles Yu; Masatsugu Ema; Mark I. Rosenblatt; Jin-Hong Chang; et al. (Angiogenesis, 2018)

Human microvasculature-on-a chip: anti-neovasculogenic effect of nintedanib in vitro - Soheila Zeinali; Colette A. Bichsel; Nina Hobi; Manuela Funke; Thomas M. Marti; Ralph A. Schmid; Olivier T. Guenat; Thomas Geiser (Angiogenesis, 2018)

miR-153 inhibits the migration and the tube formation of endothelial cells by blocking the paracrine of angiopoietin 1 in breast cancer cells - Huichun Liang; Fei Ge; Yuhui Xu; Ji Xiao; Zhongmei Zhou; Rong Liu; Ceshi Chen (Angiogenesis, 2018)

Regulation of angiogenesis by microRNAs in cardiovascular diseases - Devika Kir; Erica Schnettler; Shrey Modi; Sundaram Ramakrishnan (Angiogenesis, 2018)

Heparin impairs angiogenic signaling and compensatory lung growth after left pneumonectomy - Duy T. Dao; Lorenzo Anez-Bustillos; Jared Ourieff; Amy Pan; Paul D. Mitchell; Hiroko Kishikawa; Gillian L. Fell; Meredith A. Baker; Randolph S. Watnick; Hong Chen; Thomas E. Hamilton; Michael S. Rogers; et al. (Angiogenesis, 2018)

IGF2 and IGF1R identified as novel tip cell genes in primary microvascular endothelial cell monolayers - Marchien G. Dallinga; Bahar Yetkin-Arik; Richelle P. Kayser; Ilse M. C. Vogels; Patrycja Nowak-Sliwinska; Arjan W. Griffioen; Cornelis J. F. van Noorden; Ingeborg Klaassen; Reinier O. Schlingemann (Angiogenesis, 2018)

Correction to: Gene therapy knockdown of VEGFR2 in retinal endothelial cells to treat retinopathy - Aaron B. Simmons; Colin A. Bretz; Haibo Wang; Eric Kunz; Kassem Hajj; Carson Kennedy; Zhihong Yang; Thipparat Suwanmanee; Tal Kafri; M. Elizabeth Hartnett (Angiogenesis, 2018)

Prion protein is essential for diabetic retinopathy-associated neovascularization - Lingyan Zhu; Jixiong Xu; Ying Liu; Tian Gong; Jianying Liu; Qiong Huang; Shane Fischbach; Wenquan Zou; Xiangwei Xiao (Angiogenesis, 2018)

Endothelial loss of Fzd5 stimulates PKC/Ets1-mediated transcription of Angpt2 and Flt1 - Maarten M. Brandt; Christian G. M. van Dijk; Ihsan Chrifi; Heleen M. Kool; Petra E. Bürgisser; Laura Louzao-Martinez; Jiayi Pei; Robbert J. Rottier; Marianne C. Verhaar; Dirk J. Duncker; Caroline Cheng (Angiogenesis, 2018)

A xenograft model for venous malformation - Jillian Goines; Xian Li; Yuqi Cai; Paula Mobberley-Schuman; Megan Metcalf; Steven J. Fishman; Denise M. Adams; Adrienne M. Hammill; Elisa Boscolo (Angiogenesis, 2018)

Preclinical impact of high dose intermittent antiangiogenic tyrosine kinase inhibitor pazopanib in intrinsically resistant tumor models - Elaine Reguera-Nuñez; Shan Man; Ping Xu; Robert S. Kerbel (Angiogenesis, 2018)

Improved recovery from limb ischaemia by delivery of an affinity-isolated heparan sulphate - Selina Poon; Xiaohua Lu; Raymond A. A. Smith; Pei Ho; Kishore Bhakoo; Victor Nurcombe; Simon M. Cool (Angiogenesis, 2018)

Targeting glioblastoma-derived pericytes improves chemotherapeutic outcome - Daniel A. P. Guerra; Ana E. Paiva; Isadora F. G. Sena; Patrick O. Azevedo; Walison N. Silva; Akiva Mintz; Alexander Birbrair (Angiogenesis, 2018)

Correction to: Soluble delta-like 1 homolog (DLK1) stimulates angiogenesis through Notch1/Akt/eNOS signaling in endothelial cells - Chao-Cheng Huang; Hsiao-Mei Kuo; Pei-Chang Wu; Shih-Hsuan Cheng; Tzu-Ting Chang; Yi-Chen Chang; Mei-Lang Kung; Deng-Chyang Wu; Jiin-Haur Chuang; Ming-Hong Tai (Angiogenesis, 2018)

eNOS expression and NO release during hypoxia is inhibited by miR-200b in human endothelial cells - Anna Janaszak-Jasiecka; Anna Siekierzycka; Sylwia Bartoszewska; Marcin Serocki; Lawrence W. Dobrucki; James F. Collawn; Leszek Kalinowski; Rafal Bartoszewski (Angiogenesis, 2018)

Gene therapy knockdown of VEGFR2 in retinal endothelial cells to treat retinopathy - Aaron B. Simmons; Colin A. Bretz; Haibo Wang; Eric Kunz; Kassem Hajj; Carson Kennedy; Zhihong Yang; Thipparat Suwanmanee; Tal Kafri; M. Elizabeth Hartnett (Angiogenesis, 2018)

Assessment of the direct effects of DDAH I on tumour angiogenesis in vivo - Efthymia Papaevangelou; Jessica K. R. Boult; Guy S. Whitley; Simon P. Robinson; Franklyn A. Howe (Angiogenesis, 2018)

Consensus guidelines for the use and interpretation of angiogenesis assays - Patrycja Nowak-Sliwinska; Kari Alitalo; Elizabeth Allen; Andrey Anisimov; Alfred C. Aplin; Robert Auerbach; Hellmut G. Augustin; David O. Bates; Judy R. van Beijnum; R. Hugh F. Bender; Gabriele Bergers; Andreas Bikfalvi; et al. (Angiogenesis, 2018)

Angio-3, a 10-residue peptide derived from human plasminogen kringle 3, suppresses tumor growth in mice via impeding both angiogenesis and vascular permeability - Shruthi Venugopal; Chieh Kao; Ritu Chandna; Konerirajapuram N. Sulochana; Vivekanandan Subramanian; Mo Chen; R. Manjunatha Kini; Ruowen Ge (Angiogenesis, 2018)

BI1 is associated with microvascular protection in cardiac ischemia reperfusion injury via repressing Syk–Nox2–Drp1-mitochondrial fission pathways - Hao Zhou; Chen Shi; Shunying Hu; Hong Zhu; Jun Ren; Yundai Chen (Angiogenesis, 2018)

SNAI1, an endothelial–mesenchymal transition transcription factor, promotes the early phase of ocular neovascularization - Jia-Xing Sun; Tian-Fang Chang; Man-Hong Li; Li-Juan Sun; Xian-Chun Yan; Zi-Yan Yang; Yuan Liu; Wen-Qin Xu; Yang Lv; Jing-Bo Su; Liang Liang; Hua Han; et al. (Angiogenesis, 2018)

Spatiotemporal heterogeneity and patterning of developing renal blood vessels - Edward Daniel; D. Berfin Azizoglu; Anne R. Ryan; Tezin A. Walji; Christopher P. Chaney; Gabrielle I. Sutton; Thomas J. Carroll; Denise K. Marciano; Ondine Cleaver (Angiogenesis, 2018)

Characterization of isolated liver sinusoidal endothelial cells for liver bioengineering - A. M. Dingle; K. K. Yap; Y-W. Gerrand; C. J. Taylor; E. Keramidaris; Z. Lokmic; A. M. Kong; H. L. Peters; W. A. Morrison; G. M. Mitchell (Angiogenesis, 2018)

Extracellular vesicle-carried Jagged-1 inhibits HUVEC sprouting in a 3D microenvironment - Evan Tan; Harry H. Asada; Ruowen Ge (Angiogenesis, 2018)

Peripheral post-ischemic vascular repair is impaired in a murine model of Alzheimer’s disease - Tatyana Merkulova-Rainon; Chris S. Mantsounga; Dong Broquères-You; Cristina Pinto; José Vilar; Diana Cifuentes; Philippe Bonnin; Nathalie Kubis; Daniel Henrion; Jean-Sébastien Silvestre; Bernard I. Lévy (Angiogenesis, 2018)

Characterization of a drug-targetable allosteric site regulating vascular endothelial growth factor signaling - Katherine M. Thieltges; Dragana Avramovic; Chayne L. Piscitelli; Sandra Markovic-Mueller; Hans Kaspar Binz; Kurt Ballmer-Hofer (Angiogenesis, 2018)

Different angioregulatory activity of monovalent galectin-9 isoforms - Ed Aanhane; Iris A. Schulkens; Roy Heusschen; Kitty Castricum; Hakon Leffler; Arjan W. Griffioen; Victor L. Thijssen (Angiogenesis, 2018)

Platelet function is disturbed by the angiogenesis inhibitors sunitinib and sorafenib, but unaffected by bevacizumab - Maudy Walraven; Marjolein Y. V. Homs; Astrid A. M. van der Veldt; Henk Dekker; Jose Koldenhof; Richard Honeywell; Arjan Barendrecht; Silvie A. E. Sebastian; Naomi Parr; Arnold C. Koekman; Emile E. Voest; Mark Roest; et al. (Angiogenesis, 2018)

Serum/glucocorticoid-regulated kinase 1 as a novel transcriptional target of bone morphogenetic protein-ALK1 receptor signaling in vascular endothelial cells - Mutsumi Araki; Takashi Hisamitsu; Yumi Kinugasa-Katayama; Toru Tanaka; Yukihiro Harada; Shu Nakao; Sanshiro Hanada; Shuhei Ishii; Masahide Fujita; Teruhisa Kawamura; Yoshihiko Saito; Koichi Nishiyama; et al. (Angiogenesis, 2018)

Vascular deficiency of Smad4 causes arteriovenous malformations: a mouse model of Hereditary Hemorrhagic Telangiectasia - Angela M. Crist; Amanda R. Lee; Nehal R. Patel; Dawn E. Westhoff; Stryder M. Meadows (Angiogenesis, 2018)

High-density lipoprotein (HDL) promotes angiogenesis via S1P3-dependent VEGFR2 activation - Fengyan Jin; Nina Hagemann; Li Sun; Jiang Wu; Thorsten R. Doeppner; Yun Dai; Dirk M. Hermann (Angiogenesis, 2018)

Time-dependent LXR/RXR pathway modulation characterizes capillary remodeling in inflammatory corneal neovascularization - Anthony Mukwaya; Anton Lennikov; Maria Xeroudaki; Pierfrancesco Mirabelli; Mieszko Lachota; Lasse Jensen; Beatrice Peebo; Neil Lagali (Angiogenesis, 2018)

Visualization of endothelial cell cycle dynamics in mouse using the Flt-1/eGFP-anillin system - Katia Herz; Alexandra Becker; Chenyue Shi; Masatsugo Ema; Satoru Takahashi; Michael Potente; Michael Hesse; Bernd K. Fleischmann; Daniela Wenzel (Angiogenesis, 2018)

Somatic NRAS mutation in patient with generalized lymphatic anomaly - Eugenia Manevitz-Mendelson; Gil S. Leichner; Ortal Barel; Inbal Davidi-Avrahami; Limor Ziv-Strasser; Eran Eyal; Itai Pessach; Uri Rimon; Aviv Barzilai; Abraham Hirshberg; Keren Chechekes; Ninette Amariglio; et al. (Angiogenesis, 2018)

Glomerular endothelial cell maturation depends on ADAM10, a key regulator of Notch signaling - Gregory Farber; Romulo Hurtado; Sarah Loh; Sébastien Monette; James Mtui; Raphael Kopan; Susan Quaggin; Catherine Meyer-Schwesinger; Doris Herzlinger; Rizaldy P. Scott; Carl P. Blobel (Angiogenesis, 2018)

Soluble delta-like 1 homolog (DLK1) stimulates angiogenesis through Notch1/Akt/eNOS signaling in endothelial cells - Chao-Cheng Huang; Hsiao-Mei Kuo; Pei-Chang Wu; Shih-Hsuan Cheng; Tzu-Ting Chang; Yi-Chen Chang; Mei-Lang Kung; Deng-Chyang Wu; Jiin-Haur Chuang; Ming-Hong Tai (Angiogenesis, 2018)

miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target - Marcin Serocki; Sylwia Bartoszewska; Anna Janaszak-Jasiecka; Renata J. Ochocka; James F. Collawn; Rafał Bartoszewski (Angiogenesis, 2018)

Direct repression of IGF2 is implicated in the anti-angiogenic function of microRNA-210 in human retinal endothelial cells - Qinbo Yang; Peiwei Wang; Xiaoye Du; Wenjian Wang; Teng Zhang; Yu Chen (Angiogenesis, 2018)

Selective IKK2 inhibitor IMD0354 disrupts NF-κB signaling to suppress corneal inflammation and angiogenesis - Anton Lennikov; Pierfrancesco Mirabelli; Anthony Mukwaya; Mira Schaupper; Muthukumar Thangavelu; Mieszko Lachota; Zaheer Ali; Lasse Jensen; Neil Lagali (Angiogenesis, 2018)

Oxidized phospholipids stimulate production of stem cell factor via NRF2-dependent mechanisms - Taras Afonyushkin; Olga V. Oskolkova; Valery N. Bochkov (Angiogenesis, 2018)

IL-11 facilitates a novel connection between RA joint fibroblasts and endothelial cells - Hatem A. Elshabrawy; Michael V. Volin; Abdul B. Essani; Zhenlong Chen; Iain B. McInnes; Katrien Van Raemdonck; Karol Palasiewicz; Shiva Arami; Mark Gonzalez; Hossam M. Ashour; Seung-jae Kim; Guofei Zhou; et al. (Angiogenesis, 2018)

Chronic mild hypoxia promotes profound vascular remodeling in spinal cord blood vessels, preferentially in white matter, via an α5β1 integrin-mediated mechanism - Sebok K. Halder; Ravi Kant; Richard Milner (Angiogenesis, 2018)

Slit2/Robo1 signaling is involved in angiogenesis of glomerular endothelial cells exposed to a diabetic-like environment - Junhui Liu; Weiping Hou; Tao Guan; Luyao Tang; Xufei Zhu; Yi Li; Shihui Hou; Jun Zhang; Hua Chen; Yunjian Huang (Angiogenesis, 2018)

Tip-cell behavior is regulated by transcription factor FoxO1 under hypoxic conditions in developing mouse retinas - Moe Fukumoto; Kanako Kondo; Kazumasa Uni; Tomoko Ishiguro; Mikiko Hayashi; Shinnosuke Ueda; Itsuki Mori; Kenta Niimi; Fumi Tashiro; Satsuki Miyazaki; Jun-Ichi Miyazaki; Shinobu Inagaki; et al. (Angiogenesis, 2018)

AAV-mediated gene delivery of the calreticulin anti-angiogenic domain inhibits ocular neovascularization - Leilei Tu; Jiang-Hui Wang; Veluchamy A. Barathi; Selwyn M. Prea; Zheng He; Jia Hui Lee; James Bender; Anna E. King; Grant J. Logan; Ian E. Alexander; Youn-Shen Bee; Ming-Hong Tai; et al. (Angiogenesis, 2018)

12th International HHT Scientific Conference (Angiogenesis, 2018)

Dimethylarginine dimethylaminohydrolase-1 (DDAH1) is frequently upregulated in prostate cancer, and its overexpression conveys tumor growth and angiogenesis by metabolizing asymmetric dimethylarginine (ADMA) - Karthik Reddy Kami Reddy; Chandrashekhar Dasari; Divya Duscharla; Bhukya Supriya; N. Sai Ram; M. V. Surekha; Jerald Mahesh Kumar; Ramesh Ummanni (Angiogenesis, 2018)

Noninvasive induction of angiogenesis in tissues by external suction: sequential optimization for use in reconstructive surgery - G. Giatsidis; L. Cheng; Anthony Haddad; K. Ji; J. Succar; L. Lancerotto; J. Lujan-Hernandez; P. Fiorina; H. Matsumine; D. P. Orgill (Angiogenesis, 2018)

Executive summary of the 12th HHT international scientific conference - Jillian W. Andrejecsk; Anna E. Hosman; Luisa M. Botella; Claire L. Shovlin; Helen M. Arthur; Sophie Dupuis-Girod; Elisabetta Buscarini; Christopher C. W. Hughes; Franck Lebrin; Christine L. Mummery; Marco C. Post; Johannes J. Mager (Angiogenesis, 2018)

Mechanisms of angiogenesis in microbe-regulated inflammatory and neoplastic conditions - Sanaullah Sajib; Fatema Tuz Zahra; Michail S. Lionakis; Nadezhda A. German; Constantinos M. Mikelis (Angiogenesis, 2018)

N-tert-butyloxycarbonyl-Phe-Leu-Phe-Leu-Phe (BOC2) inhibits the angiogenic activity of heparin-binding growth factors - Imtiaz M. Nawaz; Paola Chiodelli; Sara Rezzola; Giuseppe Paganini; Michela Corsini; Alessio Lodola; Alessio Di Ianni; Marco Mor; Marco Presta (Angiogenesis, 2018)

Notch signaling controls sprouting angiogenesis of endometriotic lesions - Christina Körbel; Miriam D. Gerstner; Michael D. Menger; Matthias W. Laschke (Angiogenesis, 2018)

Antiangiogenesis and medical therapy failure in intracranial atherosclerosis - Nestor R. Gonzalez; Raymond Liou; Florian Kurth; Hao Jiang; Jeffrey Saver (Angiogenesis, 2018)

Pre-culture in endothelial growth medium enhances the angiogenic properties of adipose-derived stem/stromal cells - Lucas E. B. Souza; Liziane R. Beckenkamp; Lays M. Sobral; Daianne M. C. Fantacini; Fernanda U. F. Melo; Josiane S. Borges; Andréia M. Leopoldino; Simone Kashima; Dimas Tadeu Covas (Angiogenesis, 2018)

Bone marrow sinusoidal endothelium: damage and potential regeneration following cancer radiotherapy or chemotherapy - Mohammadhossein Hassanshahi; Alireza Hassanshahi; Samira Khabbazi; Yu-Wen Su; Cory J. Xian (Angiogenesis, 2017)

A genomic screen for angiosuppressor genes in the tumor endothelium identifies a multifaceted angiostatic role for bromodomain containing 7 (BRD7) - Judy R. van Beijnum; Patrycja Nowak-Sliwinska; Maaike van Berkel; Tse J. Wong; Arjan W. Griffioen (Angiogenesis, 2017)

3D endothelial cell spheroid/human vitreous humor assay for the characterization of anti-angiogenic inhibitors for the treatment of proliferative diabetic retinopathy - Sara Rezzola; Imtiaz M. Nawaz; Anna Cancarini; Cosetta Ravelli; Stefano Calza; Francesco Semeraro; Marco Presta (Angiogenesis, 2017)

Tumor vessel disintegration by maximum tolerable PFKFB3 blockade - Lena-Christin Conradi; Aleksandra Brajic; Anna Rita Cantelmo; Ann Bouché; Joanna Kalucka; Andreas Pircher; Ulrike Brüning; Laure-Anne Teuwen; Stefan Vinckier; Bart Ghesquière; Mieke Dewerchin; Peter Carmeliet (Angiogenesis, 2017)

Frizzled-5: a high affinity receptor for secreted frizzled-related protein-2 activation of nuclear factor of activated T-cells c3 signaling to promote angiogenesis - Yuri K. Peterson; Patrick Nasarre; Ingrid V. Bonilla; Eleanor Hilliard; Jennifer Samples; Thomas A. Morinelli; Elizabeth G. Hill; Nancy Klauber-DeMore (Angiogenesis, 2017)

Endothelial progenitor cells in multiple myeloma neovascularization: a brick to the wall - Maria Margarida Tenreiro; Maria Leonor Correia; Maria Alexandra Brito (Angiogenesis, 2017)

Prox1-GFP/Flt1-DsRed transgenic mice: an animal model for simultaneous live imaging of angiogenesis and lymphangiogenesis - Wei Zhong; Xinbo Gao; Shuangyong Wang; Kyuyeon Han; Masatsugu Ema; Susanne Adams; Ralf H. Adams; Mark I. Rosenblatt; Jin-Hong Chang; Dimitri T. Azar (Angiogenesis, 2017)

PDGFRβ-P2A-CreERT2 mice: a genetic tool to target pericytes in angiogenesis - Henar Cuervo; Brianna Pereira; Taliha Nadeem; Mika Lin; Frances Lee; Jan Kitajewski; Chyuan-Sheng Lin (Angiogenesis, 2017)

Microvascular ultrastructural changes precede cognitive impairment in the murine APPswe/PS1dE9 model of Alzheimer’s disease - Patricia Kelly; Paul Denver; Simon C. Satchell; Maximilian Ackermann; Moritz A. Konerding; Christopher A. Mitchell (Angiogenesis, 2017)

A new key player in VEGF-dependent angiogenesis in human hepatocellular carcinoma: dimethylarginine dimethylaminohydrolase 1 - Nikki Buijs; J. Efraim Oosterink; Morgan Jessup; Henk Schierbeek; Donna B. Stolz; Alexander P. Houdijk; David A. Geller; Paul A. van Leeuwen (Angiogenesis, 2017)

History and conceptual developments in vascular biology and angiogenesis research: a personal view - Andreas Bikfalvi (Angiogenesis, 2017)

Erratum to: miRNAs: micro-managers of anticancer combination therapies - Judy R. van Beijnum; Elisa Giovannetti; Dennis Poel; Patrycja Nowak-Sliwinska; Arjan W. Griffioen (Angiogenesis, 2017)

Early prediction of tumor response to bevacizumab treatment in murine colon cancer models using three-dimensional dynamic contrast-enhanced ultrasound imaging - Jianhua Zhou; Huiping Zhang; Huaijun Wang; Amelie M. Lutz; Ahmed El Kaffas; Lu Tian; Dimitre Hristov; Jürgen K. Willmann (Angiogenesis, 2017)

Optical clearing and fluorescence deep-tissue imaging for 3D quantitative analysis of the brain tumor microenvironment - Tonny Lagerweij; Sophie A. Dusoswa; Adrian Negrean; Esther M. L. Hendrikx; Helga E. de Vries; Jeroen Kole; Juan J. Garcia-Vallejo; Huibert D. Mansvelder; W. Peter Vandertop; David P. Noske; Bakhos A. Tannous; René J. P. Musters; et al. (Angiogenesis, 2017)

Endothelium-derived fibronectin regulates neonatal vascular morphogenesis in an autocrine fashion - Christopher J. Turner; Kwabena Badu-Nkansah; Richard O. Hynes (Angiogenesis, 2017)

Tumor angiogenesis and vascular normalization: alternative therapeutic targets - Claire Viallard; Bruno Larrivée (Angiogenesis, 2017)

Pharmacological intervention of MKL/SRF signaling by CCG-1423 impedes endothelial cell migration and angiogenesis - David Gau; William Veon; Teresa L. Capasso; Ralph Bottcher; Sanjeev Shroff; Beth L. Roman; Partha Roy (Angiogenesis, 2017)

CXCL10 suppression of hem- and lymph-angiogenesis in inflamed corneas through MMP13 - Nan Gao; Xiaowei Liu; Jiayin Wu; Juan Li; Chen Dong; Xinyi Wu; Xiao Xiao; Fu-Shin X. Yu (Angiogenesis, 2017)

Low levels of physiological interstitial flow eliminate morphogen gradients and guide angiogenesis - Venktesh S. Shirure; Andrew Lezia; Arnold Tao; Luis F. Alonzo; Steven C. George (Angiogenesis, 2017)

Pathogenic role and therapeutic potential of pleiotrophin in mouse models of ocular vascular disease - Weiwen Wang; Michelle E. LeBlanc; Xiuping Chen; Ping Chen; Yanli Ji; Megan Brewer; Hong Tian; Samantha R. Spring; Keith A. Webster; Wei Li (Angiogenesis, 2017)

Pulsatile high-dose treatment with antiangiogenic tyrosine kinase inhibitors improves clinical antitumor activity - Maria Rovithi; Henk M. W. Verheul (Angiogenesis, 2017)

A novel strategy to enhance angiogenesis in vivo using the small VEGF-binding peptide PR1P - Avner Adini; Irit Adini; Zai-long Chi; Ratmir Derda; Amy E. Birsner; Benjamin D. Matthews; Robert J. D’Amato (Angiogenesis, 2017)

Pro-angiogenic capacities of microvesicles produced by skin wound myofibroblasts - Mays Merjaneh; Amélie Langlois; Sébastien Larochelle; Chanel Beaudoin Cloutier; Sylvie Ricard-Blum; Véronique J. Moulin (Angiogenesis, 2017)

Blood flow can signal during angiogenesis not only through mechanotransduction, but also by affecting growth factor distribution - Siavash Ghaffari; Richard L. Leask; Elizabeth A. V. Jones (Angiogenesis, 2017)

Effects of nintedanib on the microvascular architecture in a lung fibrosis model - Maximilian Ackermann; Yong Ook Kim; Willi L. Wagner; Detlef Schuppan; Cristian D. Valenzuela; Steven J. Mentzer; Sebastian Kreuz; Detlef Stiller; Lutz Wollin; Moritz A. Konerding (Angiogenesis, 2017)

RCAN1.4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells - Ahmad F. Alghanem; Emma L. Wilkinson; Maxine S. Emmett; Mohammad A. Aljasir; Katherine Holmes; Beverley A. Rothermel; Victoria A. Simms; Victoria L. Heath; Michael J. Cross (Angiogenesis, 2017)

MCPIP1 contributes to clear cell renal cell carcinomas development - Janusz Ligeza; Paulina Marona; Natalia Gach; Barbara Lipert; Katarzyna Miekus; Waclaw Wilk; Janusz Jaszczynski; Andrzej Stelmach; Agnieszka Loboda; Jozef Dulak; Wojciech Branicki; Janusz Rys; et al. (Angiogenesis, 2017)

The role of vasculature in bone development, regeneration and proper systemic functioning - Joanna Filipowska; Krzysztof A. Tomaszewski; Łukasz Niedźwiedzki; Jerzy A. Walocha; Tadeusz Niedźwiedzki (Angiogenesis, 2017)

A somatic GNA11 mutation is associated with extremity capillary malformation and overgrowth - Javier A. Couto; Ugur M. Ayturk; Dennis J. Konczyk; Jeremy A. Goss; August Y. Huang; Steve Hann; Jennifer L. Reeve; Marilyn G. Liang; Joyce Bischoff; Matthew L. Warman; Arin K. Greene (Angiogenesis, 2017)

ETS transcription factors Etv2 and Fli1b are required for tumor angiogenesis - Kristina Baltrunaite; Michael P. Craig; Sharina Palencia Desai; Praneet Chaturvedi; Ram Naresh Pandey; Rashmi S. Hegde; Saulius Sumanas (Angiogenesis, 2017)

Erratum to: Contribution of tumor endothelial cells to drug resistance: anti-angiogenic tyrosine kinase inhibitors act as p-glycoprotein antagonists - MariaRosa Bani; Alessandra Decio; Raffaella Giavazzi; Carmen Ghilardi (Angiogenesis, 2017)

miRNAs: micro-managers of anticancer combination therapies - Judy R. van Beijnum; Elisa Giovannetti; Dennis Poel; Patrycja Nowak-Sliwinska; Arjan W. Griffioen (Angiogenesis, 2017)

Antiangiogenic therapy combined with immune checkpoint blockade in renal cancer - Teele Kuusk; Laurence Albiges; Bernard Escudier; Nikolaos Grivas; John Haanen; Thomas Powles; Axel Bex (Angiogenesis, 2017)

Contribution of tumor endothelial cells to drug resistance: anti-angiogenic tyrosine kinase inhibitors act as p-glycoprotein antagonists - MariaRosa Bani; Alessandra Decio; Raffaella Giavazzi; Carmen Ghilardi (Angiogenesis, 2017)

Angiogenesis inhibitors in combinatorial approaches - Patrycja Nowak-Sliwinska; Arjan W. Griffioen (Angiogenesis, 2017)

Epigenetic approach for angiostatic therapy: promising combinations for cancer treatment - Robert H. Berndsen; U. Kulsoom Abdul; Andrea Weiss; Marloes Zoetemelk; Marije T. te Winkel; Paul J. Dyson; Arjan W. Griffioen; Patrycja Nowak-Sliwinska (Angiogenesis, 2017)

The clinical application of angiostatic therapy in combination with radiotherapy: past, present, future - Lisanne C. Hamming; Ben J. Slotman; Henk M. W. Verheul; Victor L. Thijssen (Angiogenesis, 2017)

Anti-angiogenesis for cancer revisited: Is there a role for combinations with immunotherapy? - Rakesh R. Ramjiawan; Arjan W. Griffioen; Dan G. Duda (Angiogenesis, 2017)

Angiopoietins as serum biomarkers for lymphatic anomalies - Timothy D. Le Cras; Paula S. Mobberley-Schuman; Mary Broering; Lin Fei; Cameron C. Trenor; Denise M. Adams (Angiogenesis, 2017)

A new algorithm for a better characterization and timing of the anti-VEGF vascular effect named “normalization” - Karima El Alaoui-Lasmaili; El-Hadi Djermoune; Jean-Baptiste Tylcz; Dominique Meng; François Plénat; Noémie Thomas; Béatrice Faivre (Angiogenesis, 2017)

The role of endoglin in post-ischemic revascularization - Elena Núñez-Gómez; Miguel Pericacho; Claudia Ollauri-Ibáñez; Carmelo Bernabéu; José M. López-Novoa (Angiogenesis, 2017)

An extracellular proteasome releases endostatin from human collagen XVIII - Maria L. V. Reiss-Pistilli; Detlef Schuppan; Madalena M. S. Barroso; Iranaia Assunção-Miranda; Shirley Farias; Letícia Lery; Michael Bauer; Luiz Juliano; Maria A. Juliano; Tatiana Coelho-Sampaio (Angiogenesis, 2017)

An exploratory association of polymorphisms in angiogenesis-related genes with susceptibility, clinical response and toxicity in gastrointestinal stromal tumors receiving sunitinib after imatinib failure - Gloria Ravegnini; Margherita Nannini; Corrado Zenesini; Vittorio Simeon; Giulia Sammarini; Milena Urbini; Lidia Gatto; Maristella Saponara; Guido Biasco; Maria A. Pantaleo; Nicola Venturoli; Patrizia Hrelia; et al. (Angiogenesis, 2017)

Differential regulation of angiogenic cellular processes and claudin-5 by histamine and VEGF via PI3K-signaling, transcription factor SNAI2 and interleukin-8 - Johanna P. Laakkonen; Jari P. Lappalainen; Thomas L. Theelen; Pyry I. Toivanen; Tiina Nieminen; Suvi Jauhiainen; Minna U. Kaikkonen; Judith C. Sluimer; Seppo Ylä-Herttuala (Angiogenesis, 2017)

Enhanced peripheral dopamine impairs post-ischemic healing by suppressing angiotensin receptor type 1 expression in endothelial cells and inhibiting angiogenesis - Chandrani Sarkar; Ramesh K. Ganju; Vincent J. Pompili; Debanjan Chakroborty (Angiogenesis, 2017)

Tissue factor is an angiogenic-specific receptor for factor VII-targeted immunotherapy and photodynamic therapy - Zhiwei Hu; Jijun Cheng; Jie Xu; Wolfram Ruf; Charles J. Lockwood (Angiogenesis, 2017)

Lymphangiogenesis in rat asthma model - Aigul Moldobaeva; John Jenkins; Qiong Zhong; Elizabeth M. Wagner (Angiogenesis, 2017)

BP-1T, an antiangiogenic benzophenone-thiazole pharmacophore, counteracts HIF-1 signalling through p53/MDM2-mediated HIF-1α proteasomal degradation - Prabhu Thirusangu; V. Vigneshwaran; T. Prashanth; B. R. Vijay Avin; Vikas H. Malojirao; H. Rakesh; Shaukath Ara Khanum; Riaz Mahmood; B. T. Prabhakar (Angiogenesis, 2017)

Identification of HIF-2α-regulated genes that play a role in human microvascular endothelial sprouting during prolonged hypoxia in vitro - Tessa D. Nauta; Marloes van den Broek; Sue Gibbs; Tineke C. T. M. van der Pouw-Kraan; Cees B. Oudejans; Victor W. M. van Hinsbergh; Pieter Koolwijk (Angiogenesis, 2017)

Aliskiren decreases oxidative stress and angiogenic markers in retinal pigment epithelium cells - Sónia Simão; Daniela F. Santos; Gabriela A. Silva (Angiogenesis, 2017)

Androgens modulate male-derived endothelial cell homeostasis using androgen receptor-dependent and receptor-independent mechanisms - Verónica Torres-Estay; Daniela V. Carreño; Patricia Fuenzalida; Anica Watts; Ignacio F. San Francisco; Viviana P. Montecinos; Paula C. Sotomayor; John Ebos; Gary J. Smith; Alejandro S. Godoy (Angiogenesis, 2017)

Contrast-enhanced CT imaging in patients with chronic kidney disease - Saskia von Stillfried; Jonas C. Apitzsch; Josef Ehling; Tobias Penzkofer; Andreas H. Mahnken; Ruth Knüchel; Jürgen Floege; Peter Boor (Angiogenesis, 2016)

Regulation of lymphangiogenesis in the diaphragm by macrophages and VEGFR-3 signaling - Alexandra M. Ochsenbein; Sinem Karaman; Steven T. Proulx; Rhea Goldmann; Jyothi Chittazhathu; Athanasia Dasargyri; Chloé Chong; Jean-Christophe Leroux; E. Richard Stanley; Michael Detmar (Angiogenesis, 2016)

Prostate-specific membrane antigen (PSMA)-mediated laminin proteolysis generates a pro-angiogenic peptide - Rebecca E. Conway; Camilo Rojas; Jesse Alt; Zora Nováková; Spencer M. Richardson; Tori C. Rodrick; Julio L. Fuentes; Noah H. Richardson; Jonathan Attalla; Samantha Stewart; Beshoy Fahmy; Cyril Barinka; et al. (Angiogenesis, 2016)

Celecoxib and octreotide synergistically ameliorate portal hypertension via inhibition of angiogenesis in cirrhotic rats - Jin-Hang Gao; Shi-Lei Wen; Shi Feng; Wen-Juan Yang; Yao-Yao Lu; Huan Tong; Rui Liu; Shi-Hang Tang; Zhi-Yin Huang; Ying-Mei Tang; Jin-Hui Yang; Hui-Qi Xie; et al. (Angiogenesis, 2016)
Abnormal angiogenesis is critical for portal hypertension in cirrhosis. Except for etiological treatment, no efficient medication or regime has been explored to treat the early stage of cirrhosis when angiogenesis is initiated or overwhelming. In this study, we explored an anti-angiogenesis effort through non-cytotoxic drugs octreotide and celecoxib to treat early stage of cirrhotic portal hypertension in an animal model. Peritoneal injection of thioacetamide (TAA) was employed to induce liver cirrhosis in rats. A combination treatment of celecoxib and octreotide was found to relieve liver fibrosis, portal venous pressure, micro-hepatic arterioportal fistulas, intrahepatic and splanchnic angiogenesis. Celecoxib and octreotide exerted their anti-angiogenesis effect via an axis of cyclooxygenase-2/prostaglandin E2/EP-2/somatostatin receptor-2, which consequently down-regulated phosphorylation of extracellular signal-regulated kinase (p-ERK)–hypoxia-inducible factor-1α (HIF-1α)–vascular endothelial growth factor (VEGF) integrated signaling pathways. In conclusions, combination of celecoxib and octreotide synergistically ameliorated liver fibrosis and portal hypertension of the cirrhotic rats induced by TAA via the inhibition of intrahepatic and extrahepatic angiogenesis. The potential mechanisms behind the regimen may due to the inactivation of p-ERK–HIF-1α–VEGF signaling pathway.

A non-canonical role for desmoglein-2 in endothelial cells: implications for neoangiogenesis - Lisa M. Ebert; Lih Y. Tan; M. Zahied Johan; Kay Khine Myo Min; Michaelia P. Cockshell; Kate A. Parham; Kelly L. Betterman; Paceman Szeto; Samantha Boyle; Lokugan Silva; Angela Peng; YouFang Zhang; et al. (Angiogenesis, 2016)

Persistent infiltration and pro-inflammatory differentiation of monocytes cause unresolved inflammation in brain arteriovenous malformation - Rui Zhang; Zhenying Han; Vincent Degos; Fanxia Shen; Eun-Jung Choi; Zhengda Sun; Shuai Kang; Michael Wong; Wan Zhu; Lei Zhan; Helen M. Arthur; S. Paul Oh; et al. (Angiogenesis, 2016)

Pigment epithelium-derived factor (PEDF): a novel trophoblast-derived factor limiting feto-placental angiogenesis in late pregnancy - Jelena Loegl; Erika Nussbaumer; Ursula Hiden; Alejandro Majali-Martinez; Nassim Ghaffari-Tabrizi-Wizy; Silvija Cvitic; Ingrid Lang; Gernot Desoye; Berthold Huppertz (Angiogenesis, 2016)

Erratum to: Vegfr3-CreER T2 mouse, a new genetic tool for targeting the lymphatic system - Ines Martinez-Corral; Lukas Stanczuk; Maike Frye; Maria Helena Ulvmar; Rodrigo Diéguez-Hurtado; David Olmeda; Taija Makinen; Sagrario Ortega (Angiogenesis, 2016)

Association of endothelial proliferation with the magnitude of weight loss during calorie restriction - Katarzyna Korybalska; Ewelina Swora-Cwynar; Joanna Łuczak; Alina Kanikowska; Natasza Czepulis; Rafał Rutkowski; Andrzej Bręborowicz; Marian Grzymisławski; Janusz Witowski (Angiogenesis, 2016)

Circulating angiopoietin-2 levels in children and adolescents with type 1 diabetes mellitus: relation to carotid and aortic intima-media thickness - Mohamed Abo El-Asrar; Nancy Samir Elbarbary; Eman Abdel Rahman Ismail; AlShaimaa Abo Bakr (Angiogenesis, 2016)

Aflibercept exhibits VEGF binding stoichiometry distinct from bevacizumab and does not support formation of immune-like complexes - Douglas A. MacDonald; Joel Martin; Kathir K. Muthusamy; Jiann-Kae Luo; Erica Pyles; Ashique Rafique; Tammy Huang; Terra Potocky; Yang Liu; Jingtai Cao; Françoise Bono; Nathalie Delesque; et al. (Angiogenesis, 2016)

EphrinB2/EphB4 pathway in postnatal angiogenesis: a potential therapeutic target for ischemic cardiovascular disease - Du Yang; Chunna Jin; Hong Ma; Mingyuan Huang; Guo-Ping Shi; Jianan Wang; Meixiang Xiang (Angiogenesis, 2016)

Plants and their active compounds: natural molecules to target angiogenesis - Kai Lu; Madhavi Bhat; Sujit Basu (Angiogenesis, 2016)

HIF inhibitors for ischemic retinopathies and cancers: options beyond anti-VEGF therapies - Saima Subhani; Divya Teja Vavilala; Mridul Mukherji (Angiogenesis, 2016)

ETS transcription factors in embryonic vascular development - Michael P. Craig; Saulius Sumanas (Angiogenesis, 2016)

mTORC2 mediates CXCL12-induced angiogenesis - Mary E. Ziegler; Michaela M. S. Hatch; Nan Wu; Steven A. Muawad; Christopher C. W. Hughes (Angiogenesis, 2016)

CD34 expression modulates tube-forming capacity and barrier properties of peripheral blood-derived endothelial colony-forming cells (ECFCs) - Dimitar Tasev; Lara S. F. Konijnenberg; Joana Amado-Azevedo; Michiel H. van Wijhe; Pieter Koolwijk; Victor W. M. van Hinsbergh (Angiogenesis, 2016)

VEGF receptor-2-specific signaling mediated by VEGF-E induces hemangioma-like lesions in normal and in malignant tissue - Ernesta Fagiani; Pascal Lorentz; Ruben Bill; Kirusigan Pavotbawan; Lucie Kopfstein; Gerhard Christofori (Angiogenesis, 2016)

Erratum to: In situ validation of VEGFR-2 and α v ß 3 integrin as targets for breast lesion characterization - Josef Ehling; Matthias Misiewicz; Saskia von Stillfried; Diana Möckel; Jessica Bzyl; Sibylle Pochon; Wiltrud Lederle; Ruth Knuechel; Twan Lammers; Moritz Palmowski; Fabian Kiessling (Angiogenesis, 2016)

Quercitrin treatment protects endothelial progenitor cells from oxidative damage via inducing autophagy through extracellular signal-regulated kinase - Kangkang Zhi; Maoquan Li; Jun Bai; Yongfa Wu; Sili Zhou; Xiaoping Zhang; Lefeng Qu (Angiogenesis, 2016)

Vegfr3-CreER T2 mouse, a new genetic tool for targeting the lymphatic system - Ines Martinez-Corral; Lukas Stanczuk; Maike Frye; Maria Helena Ulvmar; Rodrigo Diéguez-Hurtado; David Olmeda; Taija Makinen; Sagrario Ortega (Angiogenesis, 2016)

In vitro modeling of endothelial interaction with macrophages and pericytes demonstrates Notch signaling function in the vascular microenvironment - Ian W. Tattersall; Jing Du; Zhuangzhuang Cong; Bennet S. Cho; Alyssa M. Klein; Chelsea L. Dieck; Reyhaan A. Chaudhri; Henar Cuervo; James H. Herts; Jan Kitajewski (Angiogenesis, 2016)

The differential effects of metronomic gemcitabine and antiangiogenic treatment in patient-derived xenografts of pancreatic cancer: treatment effects on metabolism, vascular function, cell proliferation, and tumor growth - Donald T. Yapp; May Q. Wong; Alastair H. Kyle; Shannon M. Valdez; Jenny Tso; Andrew Yung; Piotr Kozlowski; David A. Owen; Andrzej K. Buczkowski; Stephen W. Chung; Charles H. Scudamore; Andrew I. Minchinton; et al. (Angiogenesis, 2016)

Oxidative stress induces loss of pericyte coverage and vascular instability in PGC-1α-deficient mice - Nieves García-Quintans; Cristina Sánchez-Ramos; Ignacio Prieto; Alberto Tierrez; Elvira Arza; Arantzazu Alfranca; Juan Miguel Redondo; María Monsalve (Angiogenesis, 2016)

In situ validation of VEGFR-2 and α v ß 3 integrin as targets for breast lesion characterization - Josef Ehling; Matthias Misiewicz; Saskia von Stillfried; Diana Möckel; Jessica Bzyl; Sibylle Pochon; Wiltrud Lederle; Ruth Knuechel; Twan Lammers; Moritz Palmowski; Fabian Kiessling (Angiogenesis, 2016)

Tumor vasculogenic mimicry predicts poor prognosis in cancer patients: a meta-analysis - J. P. Yang; Y. D. Liao; D. M. Mai; P. Xie; Y. Y. Qiang; L. S. Zheng; M. Y. Wang; Y. Mei; D. F. Meng; L. Xu; L. Cao; Q. Yang; et al. (Angiogenesis, 2016)

Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth - Yeon Koo; David M. Barry; Ke Xu; Keiji Tanigaki; George E. Davis; Chieko Mineo; Ondine Cleaver (Angiogenesis, 2016)

Bone marrow-derived cells in ocular neovascularization: contribution and mechanisms - Fan Gao; Huiyuan Hou; Hongliang Liang; Robert N. Weinreb; Haiyan Wang; Yusheng Wang (Angiogenesis, 2016)

Transcription factor KLF6 upregulates expression of metalloprotease MMP14 and subsequent release of soluble endoglin during vascular injury - Eunate Gallardo-Vara; Francisco J. Blanco; Mercè Roqué; Scott L. Friedman; Toru Suzuki; Luisa M. Botella; Carmelo Bernabeu (Angiogenesis, 2016)

John Hunter and the origin of the term “angiogenesis” - Paola Lenzi; Guido Bocci; Gianfranco Natale (Angiogenesis, 2016)

Lack of anti-tumor activity by anti-VEGF treatments in hepatic hemangiomas - Minsu Lee; Jin-Young Choi; Joon Seok Lim; Mi-Suk Park; Myeong-Jin Kim; Honsoul Kim (Angiogenesis, 2016)

Hypoxia paradoxically inhibits the angiogenic response of isolated vessel explants while inducing overexpression of vascular endothelial growth factor - Alfred C. Aplin; Roberto F. Nicosia (Angiogenesis, 2016)

Suppression of vascular network formation by chronic hypoxia and prolyl-hydroxylase 2 (phd2) deficiency during vertebrate development - Sanjeeva Metikala; Herbert Neuhaus; Thomas Hollemann (Angiogenesis, 2016)

Functional characterization of a VEGF-A-targeting Anticalin, prototype of a novel therapeutic human protein class - Hendrik Gille; Martin Hülsmeyer; Stefan Trentmann; Gabriele Matschiner; Hans Jürgen Christian; Todd Meyer; Ali Amirkhosravi; Laurent P. Audoly; Andreas M. Hohlbaum; Arne Skerra (Angiogenesis, 2016)

Dual role of fatty acid-binding protein 5 on endothelial cell fate: a potential link between lipid metabolism and angiogenic responses - Chen-Wei Yu; Xiaoliang Liang; Samantha Lipsky; Cagatay Karaaslan; Harry Kozakewich; Gokhan S. Hotamisligil; Joyce Bischoff; Sule Cataltepe (Angiogenesis, 2016)

Inflammation is associated with a reduced number of pro-angiogenic Tie-2 monocytes and endothelial progenitor cells in patients with critical limb ischemia - Jörn F. Dopheide; Philipp Geissler; Jennifer Rubrech; Amelie Trumpp; Geraldine C. Zeller; Karsten Bock; Bernhard Dorweiler; Friedrich Dünschede; Thomas Münzel; Markus P. Radsak; Christine Espinola-Klein (Angiogenesis, 2016)

ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis - Lauriane Janssen; Laura Dupont; Mourad Bekhouche; Agnès Noel; Cédric Leduc; Marianne Voz; Bernard Peers; Didier Cataldo; Suneel S. Apte; Johanne Dubail; Alain Colige (Angiogenesis, 2016)

Targeting VEGF-A with a vaccine decreases inflammation and joint destruction in experimental arthritis - Luca Semerano; Emilie Duvallet; Nadia Belmellat; Nicolas Marival; Nicolas Schall; Maëlle Monteil; Géraldine Grouard-Vogel; Emilie Bernier; Marc Lecouvey; Hanna Hlawaty; Sylviane Muller; Marie-Christophe Boissier; et al. (Angiogenesis, 2016)

The decrease in histone methyltransferase EZH2 in response to fluid shear stress alters endothelial gene expression and promotes quiescence - Monika Maleszewska; Byambasuren Vanchin; Martin C. Harmsen; Guido Krenning (Angiogenesis, 2016)

PML–RARa modulates the vascular signature of extracellular vesicles released by acute promyelocytic leukemia cells - Yi Fang; Delphine Garnier; Tae Hoon Lee; Esterina D’Asti; Laura Montermini; Brian Meehan; Janusz Rak (Angiogenesis, 2016)

Matrix Gla protein regulates differentiation of endothelial cells derived from mouse embryonic stem cells - Jiayi Yao; Pierre J. Guihard; Ana M. Blazquez-Medela; Yina Guo; Ting Liu; Kristina I. Boström; Yucheng Yao (Angiogenesis, 2016)

Executive summary of the 11th HHT international scientific conference - Helen Arthur; Urban Geisthoff; James R. Gossage; Christopher C. W. Hughes; Pascal Lacombe; Mary E. Meek; Paul Oh; Beth L. Roman; Scott O. Trerotola; Sebastiaan Velthuis; Whitney Wooderchak-Donahue (Angiogenesis, 2015)

11th International HHT Scientific Conference (Angiogenesis, 2015)

Aflibercept administration in neovascular age-related macular degeneration refractory to previous anti-vascular endothelial growth factor drugs: a critical review and new possible approaches to move forward - Stefano Lazzeri; Guido Ripandelli; Maria Sole Sartini; Mariacristina Parravano; Monica Varano; Marco Nardi; Teresa Di Desidero; Paola Orlandi; Guido Bocci (Angiogenesis, 2015)

Brain angioarchitecture and intussusceptive microvascular growth in a murine model of Krabbe disease - Arianna Giacomini; Maximilian Ackermann; Mirella Belleri; Daniela Coltrini; Beatrice Nico; Domenico Ribatti; Moritz A. Konerding; Marco Presta; Marco Righi (Angiogenesis, 2015)

Decline of lymphatic vessel density and function in murine skin during aging - Sinem Karaman; Dorina Buschle; Paola Luciani; Jean-Christophe Leroux; Michael Detmar; Steven T. Proulx (Angiogenesis, 2015)

Obituary: Professor Moritz Konerding (1960–2015) - Andreas Gaumann; Maximilian Ackermann; Fritz Steinberg; William Li (Angiogenesis, 2015)

Combining radiotherapy with sunitinib: lessons (to be) learned - Esther A. Kleibeuker; Matthijs A. ten Hooven; Henk M. Verheul; Ben J. Slotman; Victor L. Thijssen (Angiogenesis, 2015)

The pathogenic role of angiogenesis in rheumatoid arthritis - Hatem A. Elshabrawy; Zhenlong Chen; Michael V. Volin; Shalini Ravella; Shanti Virupannavar; Shiva Shahrara (Angiogenesis, 2015)

Metallothionein 2 regulates endothelial cell migration through transcriptional regulation of vegfc expression - Annika Schuermann; Christian S. M. Helker; Wiebke Herzog (Angiogenesis, 2015)

KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi’s sarcoma - Tao Ma; Harsh Patel; Savalan Babapoor-Farrokhran; Renty Franklin; Gregg L. Semenza; Akrit Sodhi; Silvia Montaner (Angiogenesis, 2015)

Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis - Srimathi Srinivasan; Vipul Chitalia; Rosana D. Meyer; Edward Hartsough; Manisha Mehta; Itrat Harrold; Nicole Anderson; Hui Feng; Lois E. H. Smith; Yan Jiang; Catherine E. Costello; Nader Rahimi (Angiogenesis, 2015)