Prolactin and systemic malignancies: a close association - Shailendra Kapoor (Familial Cancer, 2008)

Inequality of use of Cancer Genetics Services by members of breast, ovarian and colorectal cancer families in South East Scotland - Susan M. Holloway; Birgitta Bernhard; Harry Campbell; Roseanne Cetnarskyj; Wayne W. K. Lam (Familial Cancer, 2008)

Muir-Torre Syndrome: expanding the genotype and phenotype—a further family with a MSH6 mutation - H. R. Murphy; R. Armstrong; D. Cairns; K. L. Greenhalgh (Familial Cancer, 2008)

Psychological and cancer-specific distress at 18 months post-testing in women with demonstrated BRCA1 mutations for hereditary breast/ovarian cancer - Jon G. Reichelt; Pål Møller; Ketil Heimdal; Alv A. Dahl (Familial Cancer, 2008)

Family history of cancer in Brazil: is it being used? - Danilo V. Viana; Juvenal R. N. Góes; Cláudio S. R. Coy; Maria de Lourdes Setsuko Ayrizono; Carmen S. P. Lima; Iscia Lopes-Cendes (Familial Cancer, 2008)

Probability estimation models for prediction of BRCA1 and BRCA2 mutation carriers: COS compares favourably with other models - Hassan Roudgari; Zosia H. Miedzybrodzka; Neva E. Haites (Familial Cancer, 2008)

Prolactin levels, breast-feeding and milk production in a cohort of young healthy women from high-risk breast cancer families: implications for breast cancer risk - Maria Hietala; Håkan Olsson; Helena Jernström (Familial Cancer, 2008)

Influence of germline polymorphisms of GSTT1, GSTM1, and GSTP1 in familial versus sporadic breast cancer susceptibility and survival - Volga S. Syamala; Leelakumari Sreeja; Vani Syamala; Praveenkumar B. Raveendran; Rajan Balakrishnan; Ratheesan Kuttan; Ravindran Ankathil (Familial Cancer, 2008)

The extracolonic cancer spectrum in females with the common ‘South African’ hMLH1 c.C1528T mutation - Maria M. Blokhuis; Paul A. Goldberg; G. Elize Pietersen; Ursula Algar; A. Alvera Vorster; Dhiren Govender; Raj S. Ramesar (Familial Cancer, 2008)

Gonadal mosaicism and familial adenomatous polyposis - Angela L. Schwab; Thérèse M. F. Tuohy; Michelle Condie; Deborah W. Neklason; Randall W. Burt (Familial Cancer, 2008)

Cancer risk reduction and reproductive concerns in female BRCA1/2 mutation carriers - Ashley D. Staton; Allison W. Kurian; Kristin Cobb; Meredith A. Mills; James M. Ford (Familial Cancer, 2008)

Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC) - Johanne Geary; Peter Sasieni; Richard Houlston; Louise Izatt; Ros Eeles; Stewart J. Payne; Samantha Fisher; Shirley V. Hodgson (Familial Cancer, 2008)

Sessile serrated polyps of the colorectum are rare in patients with Lynch syndrome and in familial colorectal cancer families - S. H. Andersen; E. Lykke; M. B. Folker; I. Bernstein; S. Holck (Familial Cancer, 2008)

Is MSH2 a breast cancer susceptibility gene? - EE Ming Wong; Andrea A. Tesoriero; Gulietta M. Pupo; Margaret R. E. McCredie; Graham G. Giles; John L. Hopper; Graham J. Mann; David E. Goldgar; Melissa C. Southey (Familial Cancer, 2008)

Sebaceous adenomas in an MYH associated polyposis patient of Indian (Gujarati) origin - Vadakke Kanakath Ajith Kumar; June Anne Gold; Eleanor Mallon; Shyamala Thomas; Shirley V. Hodgson (Familial Cancer, 2008)

Loss of heterozygosity at 19p13.2 and 2q21 in tumours from familial clusters of non-medullary thyroid carcinoma - Hugo João Prazeres; Fernando Rodrigues; Paula Soares; Plamen Naidenov; Paulo Figueiredo; Beatriz Campos; Manuela Lacerda; Teresa C. Martins (Familial Cancer, 2008)

A novel MSH2 germline mutation in a Druze HNPCC family - Jamal Zidan; Renée C. Niessen; Yael Laitman; Dennie Rozeveld; Robert M. W. Hofstra; Eitan Friedman (Familial Cancer, 2008)

Characterization of the pathogenic mechanism of a novel BRCA2 variant in a Chinese family - Ava Kwong; L. P. Wong; K. Y. K. Chan; E. S. K. Ma; U. S. Khoo; J. M. Ford (Familial Cancer, 2008)

Familial breast cancer: double heterozygosity for BRCA1 and BRCA2 mutations with differing phenotypes - Margaret Smith; Susan Fawcett; Emanouil Sigalas; Richard Bell; Sophie Devery; Nikolina Andrieska; Ingrid Winship (Familial Cancer, 2008)

BRCA1/2 mutation analysis in male breast cancer families from North West England - D. G. R. Evans; Mike Bulman; Karen Young; Emma Howard; Stuart Bayliss; Andrew Wallace; Fiona Lalloo (Familial Cancer, 2008)

Hereditary diffuse gastric cancer: association with lobular breast cancer - Kasmintan A. Schrader; Serena Masciari; Niki Boyd; Sara Wiyrick; Pardeep Kaurah; Janine Senz; Wylie Burke; Henry T. Lynch; Judy E. Garber; David G. Huntsman (Familial Cancer, 2008)

Hereditary colorectal cancer syndromes: molecular genetics, genetic counseling, diagnosis and management - Henry T. Lynch; Jane F. Lynch; Patrick M. Lynch; Thomas Attard (Familial Cancer, 2008)

Pancreatic cancer and the FAMMM syndrome - Henry T. Lynch; Ramon M. Fusaro; Jane F. Lynch; Randall Brand (Familial Cancer, 2008)

A hereditary cancer syndrome seminar: perspective of a Continuing Medical Education (CME) Director - Sally C. O’Neill (Familial Cancer, 2008)

Foreword - Henry T. Lynch (Familial Cancer, 2008)

Genetic counseling and clinical management of newly diagnosed breast cancer patients at genetic risk for BRCA germline mutations: perspective of a surgical oncologist - Edibaldo Silva (Familial Cancer, 2008)

Standards of care in diagnosis and testing for hereditary colon cancer - Patrick M. Lynch (Familial Cancer, 2008)

Chemoprevention with special reference to inherited colorectal cancer - Patrick M. Lynch (Familial Cancer, 2008)

Hereditary neoplasia syndromes and the role of the surgeon - Lisa C. Coviello; Robert A. Wascher (Familial Cancer, 2008)

Hereditary gynecologic cancers: differential diagnosis, surveillance, management and surgical prophylaxis - Karen H. Lu (Familial Cancer, 2008)

The biochemical basis of microsatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch Syndrome: from bench to bedside - C. Richard Boland; Minoru Koi; Dong K. Chang; John M. Carethers (Familial Cancer, 2008)

Hereditary breast cancer: pathobiology, clinical translation, and potential for targeted cancer therapeutics - Wendy S. Rubinstein (Familial Cancer, 2008)

Roles and responsibilities of a medical geneticist - Wendy S. Rubinstein (Familial Cancer, 2008)

Pathology of the hereditary colorectal carcinoma - Zoran Gatalica; Emina Torlakovic (Familial Cancer, 2008)

Predicting BRCA1 and BRCA2 gene mutation carriers: comparison of LAMBDA, BRCAPRO, Myriad II, and modified Couch models - Noralane M. Lindor; Rachel A. Lindor; Carmel Apicella; James G. Dowty; Amanda Ashley; Katherine Hunt; Betty A. Mincey; Marcia Wilson; M. Cathie Smith; John L. Hopper (Familial Cancer, 2007)

A review of histopathological subtypes of ovarian cancer in BRCA-related French Canadian cancer families - Patricia N. Tonin; Christine M. Maugard; Chantal Perret; Anne-Marie Mes-Masson; Diane M. Provencher (Familial Cancer, 2007)

Germline mutations in the breast cancer susceptibility gene PTEN are rare in high-risk non-BRCA1/2 French Canadian breast cancer families - Frédéric Guénard; Yvan Labrie; Geneviève Ouellette; Charles Joly Beauparlant; Paul Bessette; Jocelyne Chiquette; Rachel Laframboise; Jean Lépine; Bernard Lespérance; Roxane Pichette; Marie Plante; Francine Durocher (Familial Cancer, 2007)

BRCA1, BRCA2, TP53, and CDKN2A germline mutations in patients with breast cancer and cutaneous melanoma - Christian Monnerat; Agnès Chompret; Caroline Kannengiesser; Marie-Françoise Avril; Nicolas Janin; Alain Spatz; Jean-Marc Guinebretière; Catalin Marian; Michel Barrois; Françoise Boitier; Gilbert M. Lenoir; Brigitte Bressac-de Paillerets (Familial Cancer, 2007)

Somatic alterations of the NF1 gene in an NF1 individual with multiple benign tumours (internal and external) and malignant tumour types - Gill Spurlock; Siân Griffiths; Jeremy Uff; Meena Upadhyaya (Familial Cancer, 2007)

Prognostic value of BRCA1 mutations in familial breast cancer patients affected by a second primary cancer - Pavel Elsakov; Juozas Kurtinaitis; Valerij Ostapenko (Familial Cancer, 2007)

Information recovery in cancer families: value for risk estimations - Hassan Roudgari; Lindsey F. Masson; Neva E. Haites (Familial Cancer, 2007)

Absence of the common IGF1 19 CA-repeat allele is more common among BRCA1 mutation carriers than among non-carriers from BRCA1 families - Maria Henningson; Erika Bågeman; Therese Sandberg; Åke Borg; Håkan Olsson; Helena Jernström (Familial Cancer, 2007)

Incorporation of somatic BRAF mutation testing into an algorithm for the investigation of hereditary non-polyposis colorectal cancer - M. B. Loughrey; P. M. Waring; A. Tan; M. Trivett; S. Kovalenko; V. Beshay; M.-A. Young; G. McArthur; A. Boussioutas; A. Dobrovic (Familial Cancer, 2007)

Adult weight gain and central obesity in women with and without a family history of breast cancer: a case control study - Michelle N. Harvie; Saba Bokhari; Andrew Shenton; Linda Ashcroft; Gareth Evans; Ric Swindell; Anthony Howell (Familial Cancer, 2007)

Hysteroscopic findings in women at risk of HNPCC. Results of a prospective observational study - Fabrice Lécuru; Ulrike Metzger; Catherine Scarabin; Marie Aude Le Frère Belda; Sylviane Olschwang; Pierre Laurent Puig (Familial Cancer, 2007)

Founder mutations in early-onset, familial and bilateral breast cancer patients from Russia - Anna P. Sokolenko; Maxim E. Rozanov; Natalia V. Mitiushkina; Natalia Yu. Sherina; Aglaya G. Iyevleva; Elena V. Chekmariova; Konstantin G. Buslov; Evgeny S. Shilov; Alexandr V. Togo; Elena M. Bit-Sava; Dmitry A. Voskresenskiy; Oleg L. Chagunava; et al. (Familial Cancer, 2007)

Two TP53 germline mutations in a classical Li-Fraumeni syndrome family - Liselotte P. van Hest; Mariëlle W. G. Ruijs; Anja Wagner; Conny A. van der Meer; Senno Verhoef; Laura J. van‘t Veer; Hanne Meijers-Heijboer (Familial Cancer, 2007)

Recurrent idiopathic pancreatitis in familial adenomatous polyposis: Report of a case-series and review of the literature - Aura A. J. van Esch; Joost P. H. Drenth; Rene H. M. te Morsche; Jan B. M. J. Jansen; Fokko M. Nagengast (Familial Cancer, 2007)

The 2nd Biennial Scientific Meeting of International Society for Gastrointestinal Hereditary Tumours - Takeo Iwama (Familial Cancer, 2007)

Disseminating risk information to familial adenomatous polyposis families - Claire Groombridge; Bronwyn Burgess; Allan D. Spigelman; Libby O’Toole (Familial Cancer, 2007)

An individual with Muir-Torre syndrome found to have a pathogenic MSH6 gene mutation - Angela Arnold; Stewart Payne; Samantha Fisher; Diane Fricker; Judith Soloway; Susan M. White; Marco Novelli; Kylie MacDonald; James Mackay; Richard Groves; Natalie Canham (Familial Cancer, 2007)

Patient preferences regarding recontact by cancer genetics clinicians - Constance A. Griffin; Jennifer E. Axilbund; Ann Marie Codori; Ginny Deise; Betty May; Cheryl Pendergrass; Miriam Tillery; Jill D. Trimbath; Francis M. Giardiello (Familial Cancer, 2007)

Sharing experiences of user involvement in shaping new services: the story of a national patient group - Alison Donaldson; Elizabeth Lank; Jane Maher (Familial Cancer, 2007)

Delivering cancer genetics services-new ways of working - Ros Eeles; Glyn Purland; Jane Maher; D. Gareth Evans (Familial Cancer, 2007)

Patient perspectives on the Poole PCT cancer genetics service - Helen Allen; Lynn Maxwell; Nikki Dibley; Angela Bradley; Roger Baker; Peter Thomas; Donna McBride (Familial Cancer, 2007)

Providing a community-based cancer risk assessment service for a socially and ethnically diverse population - C. Jacobs; R. Rawson; C. Campion; C. Caulfield; J. Heath; C. Burton; F. Kavalier (Familial Cancer, 2007)

Improving access to cancer genetics services in primary care: socio-economic data from North Kirklees - J. Srinivasa; E. Rowett; N. Dharni; H. Bhatt; M. Day; C. E. Chu (Familial Cancer, 2007)

Cancer genetics in rural primary care: a pilot nurse-led service using a new mobile IT system - Debbie Tozer; Cameron Lugton (Familial Cancer, 2007)

Open letter (Familial Cancer, 2007)

Competences, education and support for new roles in cancer genetics services: outcomes from the cancer genetics pilot projects - Catherine Bennett; Hilary Burton; Peter Farndon (Familial Cancer, 2007)

The role of patient users in cancer genetics services in primary care - Melanie Ripley; Deborah Sullivan; Jo Evans (Familial Cancer, 2007)

Foreword - Mike Richards (Familial Cancer, 2007)

National evaluation of NHS genetics service investments: emerging issues from the cancer genetics pilots - Graham P. Martin; Rachael Finn; Graeme Currie (Familial Cancer, 2007)

Delivery of cancer genetics services: The Royal Marsden telephone clinic model - S. Shanley; K. Myhill; R. Doherty; A. Ardern-Jones; S. Hall; C. Vince; S. Thomas; P. Aspinall; R. Eeles (Familial Cancer, 2007)

Nurse-led cancer genetics clinics in primary and secondary care in varied ethnic population areas: interaction with primary care to improve ascertainment of individuals from ethnic minorities - Zohra Gulzar; Sheila Goff; Albert Njindou; Heather Hearty; Imran Rafi; Rosie Savage; Gaya Matta; Julie Ferras; Shirley Hodgson (Familial Cancer, 2007)

The Teesside Cancer Family History Service: change management and innovation at cancer network level - Paul Brennan; Oonagh Claber; Tracey Shaw (Familial Cancer, 2007)

Family history is neglected in the work-up of patients with colorectal cancer: a quality assessment using cancer registry data - D. A. van Dijk; M. J. Oostindiër; W. M. Kloosterman-Boele; P. Krijnen; H. F. A. Vasen (Familial Cancer, 2007)

The natural history of a combined defect in MSH6 and MUTYH in a HNPCC family - Marjo van Puijenbroek; Maartje Nielsen; Tjitske H. C. M. Reinards; Marjan M. Weiss; Anja Wagner; Yvonne M. C. Hendriks; Hans F. A. Vasen; Carli M. J. Tops; Juul Wijnen; Tom van Wezel; Frederik J. Hes; Hans Morreau (Familial Cancer, 2007)

Utility of computed tomographic colonography in surveillance for hereditary nonpolyposis colorectal cancer syndrome - Laura Renkonen-Sinisalo; Arto Kivisaari; Leena Kivisaari; Seppo Sarna; Heikki J. Järvinen (Familial Cancer, 2007)

Acceptance of preventive surgeries by Israeli women who had undergone BRCA testing - Vardit Kram; Tamar Perez; Michal Sagi (Familial Cancer, 2007)

Identification of a founder BRCA2 mutation in Sardinian breast cancer families - Maria Monne; Giovanna Piras; Patrizia Fancello; Maria Cristina Santona; Antonella Uras; Gennaro Landriscina; Giuseppe Mastio; Attilio Gabbas (Familial Cancer, 2007)

The interval between cancer diagnosis among mothers and offspring in a population-based cohort - Ora Paltiel; Yehiel Friedlander; Lisa Deutsch; Rebecca Yanetz; Ronit Calderon-Margalit; Efrat Tiram; Hagit Hochner; Micha Barchana; Susan Harlap; Orly Manor (Familial Cancer, 2007)

A missense germline mutation in exon 7 of the MSH2 gene in a HNPCC family from center-Italy - Francesca Bianchi; Eva Galizia; Emilio Porfiri; Laura Belvederesi; Romina Catalani; Cristian Loretelli; Raffaella Bracci; Italo Bearzi; Chiara Turchi; Alessandra Viel; Riccardo Cellerino (Familial Cancer, 2007)

An association between the 4G polymorphism in the PAI-1 promoter and the development of aggressive fibromatosis (desmoid tumor) in familial adenomatous polyposis patients - Catherine F. Li; Robert Y. Wei; Frank Baliko; Bharati Bapat; Benjamin A. Alman (Familial Cancer, 2007)

Study comparing two types of screening provision for people with von Hippel-Lindau disease - Lindsay Fraser; Sally Watts; Anna Cargill; Stephen Sutton; Shirley Hodgson (Familial Cancer, 2007)

Familial colorectal cancer referral to regional genetics department—a single centre experience - Tony Mak; Douglas Speake; Fiona Lalloo; James Hill; D. G. R. Evans (Familial Cancer, 2007)

Improved survival in BRCA2 carriers with ovarian cancer - Tuya Pal; Jenny Permuth-Wey; Rachna Kapoor; Alan Cantor; Rebecca Sutphen (Familial Cancer, 2007)

Risks of cancer due to a single BRCA1 mutation in an extended Utah kindred - Florian D. Vogl; Mike D. Badzioch; Linda Steele; Susan L. Neuhausen; David E. Goldgar (Familial Cancer, 2007)

A case of Muir-Torre syndrome associated with mucinous hepatic cholangiocarcinoma and a novel germline mutation of the MSH2 gene - M. Vernez; P. Hutter; C. Monnerat; N. Halkic; O. Gugerli; H. Bouzourene (Familial Cancer, 2007)

The phenotypic expression of three MSH2 mutations in large Newfoundland families with Lynch syndrome - Susan Stuckless; Patrick S. Parfrey; Michael O. Woods; Janet Cox; G. William Fitzgerald; Jane S. Green; Roger C. Green (Familial Cancer, 2007)

Very high incidence of familial colorectal cancer in Newfoundland: a comparison with Ontario and 13 other population-based studies - R. C. Green; J. S. Green; S. K. Buehler; J. D. Robb; D. Daftary; S. Gallinger; J. R. McLaughlin; P. S. Parfrey; H. B. Younghusband (Familial Cancer, 2007)

Heterozygote BRCA1 status and skewed chromosome X inactivation - Anne Helbling-Leclerc; Gilbert M. Lenoir; Jean Feunteun (Familial Cancer, 2007)

Occurrence of both breast and ovarian cancer in a woman is a marker for the BRCA gene mutations: a population-based study from Western Sweden - Zakaria Einbeigi; Annika Bergman; Jeanne M. Meis-Kindblom; Anna Flodin; Cecilia Bjursell; Tommy Martinsson; Lars-Gunnar Kindblom; Jan Wahlström; Arne Wallgren; Margareta Nordling; Per Karlsson (Familial Cancer, 2007)

Gastric carcinoid: germline and somatic mutation of the neurofibromatosis type 1 gene - W. Stewart; J. P. Traynor; A. Cooke; S. Griffiths; N. F. Őnen; M. Balsitis; A. A. Shah; M. Upadhyaya; E. S. Tobias (Familial Cancer, 2007)

Molecular diagnosis of neurofibromatosis type 1: 2 years experience - Siân Griffiths; Peter Thompson; Ian Frayling; Meena Upadhyaya (Familial Cancer, 2007)

The management of families affected by hereditary non-polyposis colorectal cancer (HNPCC) - Johanne Geary; Huw J. W. Thomas; James Mackay; Huw Dorkins; Julian Barwell; Shirley V. Hodgson (Familial Cancer, 2007)

Congenital hypertrophy of the retinal pigment epithelium (CHRPE) in familial colorectal cancer - Celia S. Chen; Kerry D. Phillips; Scott Grist; Graeme Bennet; Jamie E. Craig; James S. Muecke; Graeme K. Suthers (Familial Cancer, 2006)

The 471delAAAG Mutation and C353T Polymorphism in the RNASEL Gene in Sporadic and Inherited Cancer in Israel - Efrat Dagan; Yael Laitman; Nurit Levanon; Avner Feuer; Ami A. Sidi; Jack Baniel; Yaacov Korach; Gilad Ben Baruch; Eitan Friedman; Ruth Gershoni-Baruch (Familial Cancer, 2006)

Awareness of gynecologic surveillance in women from hereditary non-polyposis colorectal cancer families - Kathleen Yang; Brian Allen; Peggy Conrad; C. Bethan Powell; Jonathan Terdiman; Lee-may Chen (Familial Cancer, 2006)

Low Frequency of CHEK2 Mutations in Familial Pancreatic Cancer - Detlef K. Bartsch; Kristina Krysewski; Mercedes Sina-Frey; Volker Fendrich; Harald Rieder; Peter Langer; Ralf Kress; Margarete Schneider; Stephan A. Hahn; Emily P. Slater (Familial Cancer, 2006)

Family History, and Impact on Clinical Presentation and Prognosis, in a Population-based Breast Cancer Cohort from the Stockholm County - Sara Margolin; Hemming Johansson; Lars Erik Rutqvist; Annika Lindblom; Tommy Fornander (Familial Cancer, 2006)

Survival from Colorectal Carcinoma in HNPCC Families as Compared to the General Population in Lithuania – Initial Results - Pavel Elsakov; Juozas Kurtinaitis (Familial Cancer, 2006)

BRCA1 and BRCA2 germline mutational spectrum and evidence for genetic anticipation in Portuguese breast/ovarian cancer families - Ana Peixoto; Natália Salgueiro; Catarina Santos; Graça Varzim; Patrícia Rocha; Maria José Soares; Deolinda Pereira; Helena Rodrigues; Maria José Bento; António Fráguas; Graça Moura; Fernando Regateiro; et al. (Familial Cancer, 2006)

Analysis of referrals to a multi-disciplinary breast cancer genetics clinic: practical and economic considerations - Marta M. Reis; Dorothy Young; Lorna McLeish; David Goudie; Alan Cook; Frank Sullivan; Helen Vysny; Alison Fordyce; Roger Black; Manouche Tavakoli; Michael Steel (Familial Cancer, 2006)

Screening behavior in women at increased familial risk for breast cancer - Yoland C. Antill; John Reynolds; Mary Anne Young; ˙ Judy A. Kirk; Katherine M. Tucker; Tarli L. Bogtstra; ˙ Shirley S. Wong; ˙ Tracy E. Dudding; Juliana L. Di Iulio; Kelly-Anne Phillips (Familial Cancer, 2006)

The added value of PMS2 immunostaining in the diagnosis of hereditary nonpolyposis colorectal cancer - Britta Halvarsson; Annika Lindblom; Eva Rambech; Kristina Lagerstedt; Mef Nilbert (Familial Cancer, 2006)

Acceptance of Preventive Surgeries by Israeli Women Who had Undergone BRCA Testing - Vardit Kram; Tamar Peretz; Michal Sagi (Familial Cancer, 2006)

Differences of Onset Age and Survival Rates in Esophageal Squamous Cell Carcinoma Cases with and without Family History of Upper Gastrointestinal Cancer from a High-incidence Area in North China - Denggui Wen; Shijie Wang; Liwei Zhang; Jianhui Zhang; Lizhen Wei; Xiuqing Zhao (Familial Cancer, 2006)

Accuracy of BRCA1 and BRCA2 Founder Mutation Analysis in Formalin-Fixed and Paraffin-Embedded (FFPE) Tissue - M. A. Adank; E. Brogi; F. Bogomolniy; E. A. Wadsworth; K. J. Lafaro; C. J. Yee; T. Kirchhoff; E. J. Meijers-Heijboer; N. D. Kauff; J. Boyd; K. Offit (Familial Cancer, 2006)

Low Prevalence of BRCA1 Exon Rearrangements in Familial and Young Sporadic Breast Cancer Patients - David Ellis; Yogen Patel; Shu C. Yau; Shirley V. Hodgson; Stephen J. Abbs (Familial Cancer, 2006)

What is the appropriate screening protocol in Lynch syndrome? - A. E. de Jong; F. M. Nagengast; J. H. Kleibeuker; P. C. van de Meeberg; H. J. van Wijk; A. Cats; G. Griffioen; H. F. A. Vasen (Familial Cancer, 2006)

Invited Commentary - Gabriela Moeslein (Familial Cancer, 2006)

The current status of chemoprevention in FAP - M. H. Wallace; P. M. Lynch (Familial Cancer, 2006)

Current ideas in desmoid tumours - N. Julian H. Sturt; Susan K. Clark (Familial Cancer, 2006)

Familial adenomatous polyposis: the practical applications of clinical and molecular screening - Paul Rozen; Finlay Macrae (Familial Cancer, 2006)

The genetics of FAP and FAP-like syndromes - Lara Lipton; Ian Tomlinson (Familial Cancer, 2006)

Restorative proctocolectomy and ileal pouch-anal anastomosis for familial adenomatous polyposis revisited - Alex Kartheuser; Pierre Stangherlin; Dimitri Brandt; Christophe Remue; Christine Sempoux (Familial Cancer, 2006)

Foreword: The future for the study of familial adenomatous polyposis - Takeo Iwama (Familial Cancer, 2006)

Surveillance and management of upper gastrointestinal disease in Familial Adenomatous Polyposis - Michelle C. Gallagher; Robin K. S. Phillips; Steffen Bulow (Familial Cancer, 2006)

Invited commentary - R. J. Nicholls (Familial Cancer, 2006)

In which patients do I perform IRA, and why? - James Church (Familial Cancer, 2006)

Invited Commentary - J. Burn (Familial Cancer, 2006)

The history of familial adenomatous polyposis - Steffen Bülow; Terri Berk; Kay Neale (Familial Cancer, 2006)

Part II Regular Articles (Familial Cancer, 2006)

A Novel Exon Duplication Event Leading to a Truncating Germ-line Mutation of the APC Gene in a Familial Adenomatous Polyposis Family - Amy McCart; Andrew Latchford; Emmanouil Volikos; Andrew Rowan; Ian Tomlinson; Andrew Silver (Familial Cancer, 2006)

The RET Mutation E768D Confers a Late-onset Familial Medullary Thyroid Carcinoma – Only Phenotype with Incomplete Penetrance: Implications for Screening and Management of Carrier Status - Tabib Dabir; Steven J. Hunter; Colin F. J. Russell; Damien McCall; Patrick J. Morrison (Familial Cancer, 2006)

A ‘Nonsense’ Mutation Leads to Aberrant Splicing of hMLH1 in a German Hereditary Non-polyposis Colorectal Cancer Family - J. Baehring; C. Sutter; M. Kadmon; M. V. Knebel Doeberitz; J. Gebert (Familial Cancer, 2006)

Compliance and Satisfaction with Long-Term Surveillance in Finnish HNPCC Families - Kirsi Pylvänäinen; Matti Kairaluoma; Jukka-Pekka Mecklin (Familial Cancer, 2006)

Determinants of Preferences for Genetic Counselling in Jewish Women - Carmel Apicella; Stuart J. Peacock; Lesley Andrews; Katherine Tucker; Agnes Bankier; Mary B. Daly; John L. Hopper (Familial Cancer, 2006)

Pharmacogenetics in the Management of Breast Cancer – Prospects for Individualised Treatment - Fiona H. Blackhall; Sacha Howell; Bill Newman (Familial Cancer, 2006)

BRCA1 and BRCA2: Chemosensitivity, Treatment Outcomes and Prognosis - William D. Foulkes (Familial Cancer, 2006)

Interleukin-10 Polymorphisms, Cancer Susceptibility and Prognosis - W. Martin Howell; Matthew J. Rose-Zerilli (Familial Cancer, 2006)

Part I Special Issue: Breast Cancer Treatment and Genetics (Familial Cancer, 2006)

Familial Cancer (special issue) Breast Cancer Treatment and Genetics - Diana M. Eccles (Familial Cancer, 2006)

Desmoid Tumors – a Characterization of Patients Seen at Mayo Clinic 1976–1999 - Taya Fallen; Marcia Wilson; Bruce Morlan; Noralane M Lindor (Familial Cancer, 2006)

Germline Mutations of the hMLH1 and hMSH2 Mismatch Repair Genes in Belgian Hereditary Nonpolyposis Colon Cancer (HNPCC) Patients - M. Spaepen; B. Vankeirsbilck; S. Van Opstal; S. Tejpar; E. Van Cutsem; K. Geboes; E. Legius; G. Matthijs (Familial Cancer, 2006)

Late-Onset Common Cancers in a Kindred with an Arg213Gln TP53 Germline Mutation - Mariëlle W. G. Ruijs; Senno Verhoef; Gea Wigbout; Roelof Pruntel; Arno N. Floore; Daphne de Jong; Laura J. van ′t Veer; Fred H. Menko (Familial Cancer, 2006)

Genotype Phenotype Correlation in Li-Fraumeni Syndrome Kindreds and its Implications for Management - R. N. Moule; S. G. Jhavar; R. A. Eeles (Familial Cancer, 2006)

Democratising Access to Genetic Services - Bryn Williams-Jones; Michael M. Burgess (Familial Cancer, 2006)

Guidelines for Disclosing Genetic Information to Family Members: From Development to Use - Béatrice Godard; Thierry Hurlimann; Martin Letendre; Nathalie Égalité (Familial Cancer, 2006)

The European Opposition Against the BRCA Gene Patents* - Gert Matthijs (Familial Cancer, 2006)

Insights into the Molecular Basis of Human Hereditary Breast Cancer from Studies of the BRCA1 BRCT Domain - J. N. Mark Glover (Familial Cancer, 2006)

The Challenge of Developing Evidence-Based Genetics Health Care in Practice - Brenda J. Wilson (Familial Cancer, 2006)

Challenges Identifying Genetic Determinants of Pediatric Cancers – the Childhood Leukemia Experience - Daniel Sinnett; Damian Labuda; Maja Krajinovic (Familial Cancer, 2006)

Mutational Targets in Colorectal Cancer Cells with Microsatellite Instability - Jacques Bertholon; Qing Wang; Carlos Maria Galmarini; Alain Puisieux (Familial Cancer, 2006)

The Value of Multi-Modal Gene Screening in HNPCC in Quebec: Three Mutations in Mismatch Repair Genes that would have not been Correctly Identified by Genomic DNA Sequencing Alone - Susan McVety; Lili Li; Isabelle Thiffault; Philip H. Gordon; Elizabeth MacNamara; Nora Wong; Karlene Australie; Lidia Kasprzak; George Chong; William D Foulkes (Familial Cancer, 2006)

BRCA1 and BRCA2 Mutations in Breast and Ovarian Cancer Syndrome: Reflection on the Creighton University Historical Series of High Risk Families - Olga M. Sinilnikova; Sylvie Mazoyer; Colette Bonnardel; Henry T. Lynch; Steven A. Narod; Gilbert M. Lenoir (Familial Cancer, 2006)

Oncogenetics and Interdisciplinary Collaborations: Essential for Progress - Henry T. Lynch (Familial Cancer, 2006)

An Analysis of Unclassified Missense Substitutions in Human BRCA1 - Sean V. Tavtigian; Paul B. Samollow; Deepika de Silva; Alun Thomas (Familial Cancer, 2006)

RETRACTED ARTICLE: Psychological Impact of Genetic Counseling for Familial Cancer: A Systematic Review and Meta-Analysis - Dejana Braithwaite; Jon Emery; Fiona Walter; A. Toby Prevost; Stephen Sutton (Familial Cancer, 2006)

Analysis of p27Kip1 Expression in Insulinomas Developed in Pancreatic β-cell Specific Men1 Mutant Mice - Sandra Fontanière; Huguette Casse; Philippe Bertolino; Chang Xian Zhang (Familial Cancer, 2006)

Partnering in Oncogenetic Research – The INHERIT BRCAs Experience: Opportunities and Challenges - Denise Avard; Peter Bridge; Lucie M. Bucci; Jocelyne Chiquette; Michel Dorval; Francine Durocher; Doug Easton; Béatrice Godard; David Goldgar; Bartha Maria Knoppers; Rachel Laframboise; Bernard Lespérance; et al. (Familial Cancer, 2006)

Linkage of a Pedigree Drawing Program and Database to a Program for Determining BRCA Mutation Carrier Probability - Sharon R. Sand; David S. DeRam; Deborah J. MacDonald; Kathleen R. Blazer; Jeffrey N. Weitzel (Familial Cancer, 2005)

Syndrome of Early Onset Colon Cancers, Hematologic Malignancies & Features of Neurofibromatosis in HNPCC Families with Homozygous Mismatch Repair Gene Mutations - Prathap Bandipalliam (Familial Cancer, 2005)

Contents Volume 4 (Familial Cancer, 2005)

Key word Index Volume 4 (Familial Cancer, 2005)

Acknowledgements (Familial Cancer, 2005)

MLH1 and MSH2 Mutations in Colombian Families with Hereditary Nonpolyposis Colorectal Cancer (Lynch syndrome) – Description of Four Novel Mutations - Alejandro Giraldo; Andrea Gómez; Gustavo Salguero; Herbert García; Fabio Aristizábal; Óscar Gutiérrez; Luis Alberto Ángel; Jorge Padrón; Carlos Martínez; Humberto Martínez; Omar Malaver; Luis Flórez; et al. (Familial Cancer, 2005)

Behavioral and Economic Impact of a Familial History of Cancers - Francois Eisinger; Carole Tarpin; Laetitia Huiart; Doug Horsman; Laetitia Rabayrol; Remi Didelot; Claire Julian-Reynier; Hagay Sobol (Familial Cancer, 2005)

BAP1 and Breast Cancer Risk - Isabelle Coupier; Pierre-Yves Cousin; David Hughes; Patricia Legoix-Né; Alexandra Trehin; Olga M. Sinilnikova; Dominique Stoppa-Lyonnet (Familial Cancer, 2005)

Patient Satisfaction of BRCA1/2 Genetic Testing by Women at High Risk for Breast Cancer Participating in a Prevention Trial - Jennifer R. Klemp; Anne O’Dea; Carolyn Chamberlain; Carol J. Fabian (Familial Cancer, 2005)

Mutational analysis of hMsh6 in Israeli HNPCC and HNPCC-like Families - Shiri Dovrat; Arie Figer; Herma H. Fidder; Pavlos Neophytou; Zvi Fireman; Ravit Geva; Jamal Zidan; Dov Flex; Shimon Bar Meir; Eitan Friedman (Familial Cancer, 2005)

Lack of Germ-line Mutations at the Specific BRCA1-IRIS Coding Sequence in 114 Spanish High-risk Breast/ovarian Families - Miguel de la Hoya; Juan Manuel Fernández; Ana Sánchez de Abajo; Alicia Tosar; Eduardo Díaz-Rubio; Trinidad Caldés (Familial Cancer, 2005)

Neurofibromatosis 2 (NF2) and Malignant Mesothelioma in a Man with a Constitutional NF2 Missense Mutation - M.E. Baser; H. Rai; A.J. Wallace; D.G.R. Evans (Familial Cancer, 2005)

Long Term Follow-up of HNPCC Gene Mutation Carriers: Compliance with Screening and Satisfaction with Counseling and Screening Procedures - Anja Wagner; Ingrid van Kessel; Mieke G. Kriege; Carli M. J. Tops; Juul Th. Wijnen; Hans F. A. Vasen; Conny A. van der Meer; Iris I. H. van Oostrom; Hanne Meijers-Heijboer (Familial Cancer, 2005)

Survival of Patients with Ovarian Cancer due to a Mismatch Repair Defect - Th.E.M. Crijnen; M.L.G. Janssen-Heijnen; H. Gelderblom; J. Morreau; M.A. Nooij; G.G. Kenter; H.F.A. Vasen (Familial Cancer, 2005)

Gynecologic Cancers in Lynch Syndrome/HNPCC - H. Karen Lu; Russell R. Broaddus (Familial Cancer, 2005)

Surveillance in Lynch Syndrome - Jukka-Pekka Mecklin; Heikki J. Järvinen (Familial Cancer, 2005)

The Tumor Spectrum in the Lynch Syndrome - Patrice Watson; Bronson Riley (Familial Cancer, 2005)

Lynch Syndrome Genes - Päivi Peltomäki (Familial Cancer, 2005)

Evolution of the Nomenclature for the Hereditary Colorectal Cancer Syndromes - C. Richard Boland (Familial Cancer, 2005)

Clinical Description of the Lynch Syndrome [Hereditary Nonpolyposis Colorectal Cancer (HNPCC)] - H. F. A. Vasen (Familial Cancer, 2005)

Introduction - Henry T. Lynch (Familial Cancer, 2005)

Use of Microsatellite Instability and Immunohistochemistry Testing for the Identification of Individuals at Risk for Lynch Syndrome - Linnea M. Baudhuin; Lawrence J. Burgart; Olga Leontovich; Stephen N. Thibodeau (Familial Cancer, 2005)

Guest editorial - C. Richard Boland (Familial Cancer, 2005)

Frequency of Familial Colon Cancer and Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) in a Large Population Database - Richard A. Kerber; Deborah W. Neklason; Wade S. Samowitz; Randall W. Burt (Familial Cancer, 2005)

The Incidence of Lynch Syndrome - Albert de la Chapelle (Familial Cancer, 2005)

The use of preventive measures among healthy women who carry a BRCA1 or BRCA2 mutation - Kelly A. Metcalfe; Carrie Snyder; Jennifer Seidel; Danielle Hanna; Henry T. Lynch; Steven Narod (Familial Cancer, 2005)

Psychological distress in women at risk of hereditary breast/ovarian or HNPCC cancers in the absence of demonstrated mutations - Amy Østertun Geirdal; Jon G. Reichelt; Alv A. Dahl; Ketil Heimdal; Lovise Mæhle; Astrid Stormorken; Pål Møller (Familial Cancer, 2005)

Informing one’s family about genetic testing for hereditary non-polyposis colorectal cancer (HNPCC): a retrospective exploratory study - Ilse Mesters; Marlein Ausems; Sophie Eichhorn; Hans Vasen (Familial Cancer, 2005)

Genetic uptake in BRCA-mutation families is related to emotional and behavioral communication characteristics of index patients - Karin Landsbergen; Chris Verhaak; Floor Kraaimaat; Nicoline Hoogerbrugge (Familial Cancer, 2005)

SISE matters: the Sum of Information on Seventy-yr-old Equivalents measures pedigree information content when assessing the risk of HNPCC in a family - R. C. Green; J. R. McLaughlin; H. B. Younghusband (Familial Cancer, 2005)

Screening for exonic copy number mutations at MSH2 and MLH1 by MAPH - Seyed Mohammad Akrami; Malcolm G. Dunlop; Susan M. Farrington; Ian M. Frayling; Fiona MacDonald; John F. Harvey; John A. L. Armour (Familial Cancer, 2005)

APC and β-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers - Reetta Kariola; Wael M. Abdel-Rahman; Miina Ollikainen; Ralf Butzow; Päivi Peltomäki; Minna Nyström (Familial Cancer, 2005)

Predictors of participation in clinical and psychosocial follow-up of the kConFab breast cancer family cohort - Kelly-Anne Phillips; Phyllis N. Butow; Ailsa E. Stewart; Jiun-Horng Chang; Prue C. Weideman; Melanie A. Price; Sue Anne McLachlan; kConFab Investigators; Geoffrey J. Lindeman; Michael J. McKay; Michael L. Friedlander; John L. Hopper (Familial Cancer, 2005)

A comparison of the phenotype and genotype in adenomatous polyposis patients with and without a family history - Brindusa Truta; Brian A. Allen; Peggy G. Conrad; Vivian Weinberg; Glenn A. Miller; Rob Pomponio; Lara R. Lipton; Germano Guerra; Ian P. M. Tomlinson; Marvin H. Sleisenger; Young S. Kim; Jonathan P. Terdiman (Familial Cancer, 2005)

The CHEK2 1100delC allele is not relevant for risk assessment in HNPCC and HBCC Spanish families - Ana Sánchez de Abajo; Miguel de la Hoya; Javier Godino; Vicente Furió; Alicia Tosar; Pedro Pérez-Segura; Eduardo Díaz-Rubio; Trinidad Caldés (Familial Cancer, 2005)

A high frequency of germline BRCA1/2 mutations in western Sweden detected with complementary screening techniques - Annika Bergman; Anna Flodin; Yvonne Engwall; Eva L. Arkblad; Kerstin Berg; Zakaria Einbeigi; Tommy Martinsson; Jan Wahlström; Per Karlsson; Margareta Nordling (Familial Cancer, 2005)

An unusual case of Turcot’s syndrome associated with ileal adenocarcinoma, intestinal non-Hodgkin’s lymphoma, and duodenal adenocarcinoma. Review of the classification and genetic basis of Turcot’s syndrome - H. R. Murphy; W. Taylor; A. Ellis; R. Sturgess (Familial Cancer, 2005)

Ratio of male to female births in the offspring of BRCA1 and BRCA2 carriers - G. Chenevix-Trench; O. M. Sinilnikova; G. Suthers; N. Pandeya; S. Mazoyer; J. F. Sambrook; S. Goldup; D. Goldgar; H. T. Lynch; G. M. Lenoir; G. Cheetham; kConFab (Familial Cancer, 2005)

The Tyr978X BRCA1 mutation: occurrence in non-Jewish Iranians and haplotype in French-Canadian and non-Ashkenazi Jews - Lluís Quintana-Murci; Inbar Gal; Tangiz Bakhan; Hélène Quach; S Hamid Sayar; Ronit Shiri-Sverdlov; Ruth Gershoni Baruch; Ken McElreavey; Efrat Dagan; Steven Narod; Eitan Friedman (Familial Cancer, 2005)

The TP53 mutational spectrum and frequency of CHEK2*1100delC in Li–Fraumeni-like kindreds - Rina Siddiqui; Kenan Onel; Flavia Facio; Kedoudja Nafa; Louis Robles Diaz; Noah Kauff; Helen Huang; Mark Robson; Nathan Ellis; Kenneth Offit (Familial Cancer, 2005)

Measurement of psychological factors associated with genetic testing for hereditary breast, ovarian and colon cancers - Susan T. Vadaparampil; Mary Ropka; Michael E. Stefanek (Familial Cancer, 2005)

The BRCA1 exon 13 duplication in the Swedish population - Barbara Kremeyer; Maria Soller; Kristina Lagerstedt; Paula Maguire; Sylvie Mazoyer; Margareta Nordling; Jan Wahlström; Annika Lindblom (Familial Cancer, 2005)

Referrals of patients to colorectal cancer genetics services in south-east Scotland - Susan Holloway; Mary Porteous; Roseanne Cetnarskyj; Robert Rush; Sally Appleton; Dermot Gorman; Harry Campbell (Familial Cancer, 2005)

High prevalence of two BRCA1 mutations, 4154delA and 5382insC, in Latvia - Laima Tikhomirova; Olga Sinicka; Dagnija Smite; Janis Eglitis; Shirley V. Hodgson; Aivars Stengrevics (Familial Cancer, 2005)

Abdominal desmoid in familial adenomatous polyposis presenting as a pancreatic cystic lesion - Lana N. Pho; Cheryl M. Coffin; Randall W. Burt (Familial Cancer, 2005)

Author Index (Familial Cancer, 2005)

Programme (Familial Cancer, 2005)

Origins of the Leeds Castle Polyposis Group - Kay Neale (Familial Cancer, 2005)

History of the International Collaborative Group on Hereditary NonPolyposis Colorectal Cancer - Henry T. Lynch; Giuseppe Cristofaro; Paul Rozen; Hans Vasen; Patrick Lynch; Jukka-Pekka Mecklin; Jim St. John (Familial Cancer, 2005)

Multiple endocrine neoplasia type 2 - Mariola Peczkowska; Andrzej Januszewicz (Familial Cancer, 2005)

Pheochromocytoma in von Hippel–Lindau disease and neurofibromatosis type 1 - Giuseppe Opocher; Pierantonio Conton; Francesca Schiavi; Beatrice Macino; Franco Mantero (Familial Cancer, 2005)

Pheochromocytoma-associated syndromes: genes, proteins and functions of RET, VHL and SDHx - O. Gimm (Familial Cancer, 2005)

Central nervous system manifestations in VHL: genetics, pathology and clinical phenotypic features - Sven Gläsker (Familial Cancer, 2005)

Mutations of the SDHB and SDHD genes - Christian Pawlu; Birke Bausch; Hartmut P. H. Neumann (Familial Cancer, 2005)

Imaging of pheochromocytoma and paraganglioma - I. Brink; S. Hoegerle; J. Klisch; T. A. Bley (Familial Cancer, 2005)

Ophthalmological manifestations in VHL and NF 1: pathological and diagnostic implications - Klaus-Martin Kreusel (Familial Cancer, 2005)

SDHC mutations in hereditary paraganglioma/pheochromocytoma - Ulrich Müller; Christian Troidl; Stephan Niemann (Familial Cancer, 2005)

Pheochromocytoma – where are we? Where should we go? A medical and scientific odyssey - Hartmut P. H. Neumann; Giuseppe Opocher; Andrzej Januszewicz; Charis Eng (Familial Cancer, 2005)