Activating transcription factor 3 is a potential target and a new biomarker for the prognosis of atherosclerosis - Weiwei Qin; Huiyu Yang; Gaizhen Liu; Rui bai; Yunfei Bian; Zhiming Yang; Chuanshi Xiao (Human Cell, 2021)

Isolation and characterization of castration-resistant prostate cancer LNCaP95 clones - Jacky K. Leung; Teresa Tam; Jun Wang; Marianne D. Sadar (Human Cell, 2021)

Long noncoding RNA TSLNC8 enhances pancreatic cancer aggressiveness by regulating CTNNB1 expression via association with HuR - Wei Chai; Ruhai Liu; Fengshan Li; Zhiquan Zhang; Bao Lei (Human Cell, 2021)

Establishment and characterization of NCC-DDLPS1-C1: a novel patient-derived cell line of dedifferentiated liposarcoma - Ryuto Tsuchiya; Yuki Yoshimatsu; Rei Noguchi; Akane Sei; Fumitaka Takeshita; Jun Sugaya; Suguru Fukushima; Akihiko Yoshida; Seiji Ohtori; Akira Kawai; Tadashi Kondo (Human Cell, 2021)

RP11-462C24.1 suppresses proliferation and invasion of colorectal carcinoma cells by regulating HSP70 through PI3K/AKT signaling pathway - Haiqing Zhang; Guangjun Zhang; Haijun Liu; Yuanzhou Shan; Xueli Zhang (Human Cell, 2021)

Molecular characteristics associated with ferroptosis in hepatocellular carcinoma progression - Zuo Fei; Yin Lijuan; Zhuang Jing; Yang Xi; Pan Yuefen; Han Shuwen (Human Cell, 2021)

Diversity in cancer invasion phenotypes indicates specific stroma regulated programs - Ashkan Novin; Yasir Suhail; Visar Ajeti; Ruchi Goyal; Khadija Wali; Atta Seck; Alex Jackson; Kshitiz (Human Cell, 2021)

MST1 modulates Th17 activation in psoriasis via regulating TLR4-NF-κB pathway - Huayang Tang; Ze Guo; Xianfa Tang; Jinping Gao; Wenjun Wang; He Huang; Xiaodong Zheng; Hui Cheng; Yujun Sheng; Liangdan Sun (Human Cell, 2021)

FOXO3 is targeted by miR-223-3p and promotes osteogenic differentiation of bone marrow mesenchymal stem cells by enhancing autophagy - Cheng Long; Shiqiang Cen; Zhou Zhong; Chang Zhou; Gang Zhong (Human Cell, 2021)
Mesenchymal stem cells (MSCs) are a promising regenerative medicine. The roles of miRNAs in osteogenic differentiation of bone marrow MSCs (BM-MSCs) remained less reported. Forkhead Box O3 (FOXO3) and alkaline phosphatase (ALP) levels in the BM-MSCs were measured on 3, 7, and 14 days after osteogenic differentiation. After transfection of FOXO3 overexpression plasmids or siFOXO3 into BM-MSCs, factors related to osteogenic differentiation or cell autophagy were determined. Besides, 3-methyladenine or rapamycin, as well as miR-223-3p mimic or inhibitor were applied to further determine the effect of FOXO3 in BM-MSCs. FOXO3 and ALP levels were increased in a time-dependent manner with osteogenic differentiation, supported by Alizarin Red Staining. Furthermore, up-regulated FOXO3 increased levels of ALP and factors related to osteogenic differentiation by increasing levels of autophagy-related factors. FOXO3, targeted by miR-223-3p, reversed the effects of miR-223-3p on factors related to BM-MSC autophagy and osteogenic differentiation. Down-regulated miR-223-3p expression promoted osteogenic differentiation of BM-MSCs by enhancing autophagy via targeting FOXO3, suggesting the potential of miR-223-3p as a therapeutic target for enhancing bone functions.

Circ-XPR1 promotes osteosarcoma proliferation through regulating the miR-214-5p/DDX5 axis - Xiaohuan Mao; Shuren Guo; Lan Gao; Gang Li (Human Cell, 2021)

Establishment and characterization of a novel cell line, NCC-TGCT1-C1, derived from a patient with tenosynovial giant cell tumor - Rei Noguchi; Yuki Yoshimatsu; Takuya Ono; Akane Sei; Kaoru Hirabayashi; Iwao Ozawa; Kazutaka Kikuta; Tadashi Kondo (Human Cell, 2021)

Establishment and characterization of NCC-MFS2-C1: a novel patient-derived cancer cell line of myxofibrosarcoma - Rei Noguchi; Yuki Yoshimatsu; Takuya Ono; Akane Sei; Kaoru Hirabayashi; Iwao Ozawa; Kazutaka Kikuta; Tadashi Kondo (Human Cell, 2021)

BL1391: an established cell line from a human malignant peripheral nerve sheath tumor with unique genomic features - Doron Tolomeo; Antonio Agostini; Gemma Macchia; Alberto L’Abbate; Marco Severgnini; Ingrid Cifola; Maria Antonia Frassanito; Vito Racanelli; Antonio Giovanni Solimando; Felix Haglund; Fredrik Mertens; Clelia Tiziana Storlazzi (Human Cell, 2021)

RETRACTED ARTICLE: Long noncoding RNA LINC00460 promotes the progression of cervical cancer via regulation of the miR-361-3p/Gli1 axis - Fan Li; Weipei Zhu; Zhijie Wang (Human Cell, 2020)

Long non-coding RNA PVT1 can regulate the proliferation and inflammatory responses of rheumatoid arthritis fibroblast-like synoviocytes by targeting microRNA-145-5p - Jiajun Tang; Shiyu Yi; Yi Liu (Human Cell, 2020)

LncRNA ADAMTS9-AS1, as prognostic marker, promotes cell proliferation and EMT in colorectal cancer - Wanjing Chen; Qian Tu; Liang Yu; Yanyan Xu; Gang Yu; Benli Jia; Yunsheng Cheng; Yong Wang (Human Cell, 2020)

Correction to: MiR-96 promotes apoptosis of nucleus pulpous cells by targeting FRS2 - Xiaoxia Yang; Hengping Liu; Qingfeng Zhang; Kan Liu; Dong Yu; Yi Zhang; Zongting Shi (Human Cell, 2020)

The interaction between MALAT1 target, miR-143-3p, and RALGAPA2 is affected by functional SNP rs3827693 in breast cancer - Nasrin Fattahi Dolatabadi; Arezo Dehghani; Elham Shahand; Mohammadreza Yazdanshenas; Hossein Tabatabaeian; Atefe Zamani; Mansoureh Azadeh; Kamran Ghaedi (Human Cell, 2020)

INNO-406 inhibits the growth of chronic myeloid leukemia and promotes its apoptosis via targeting PTEN - Jiandong Sun; Yilin Wang; Lirong Sun (Human Cell, 2020)

LncRNA DANCR regulates the growth and metastasis of oral squamous cell carcinoma cells via altering miR-216a-5p expression - Xing-Hui Qu; You-Ling Shi; Yan Ma; Wei-Wei Bao; Lei Yang; Jin-Chao Li; Fan Zhang (Human Cell, 2020)

Review of cancer-associated fibroblasts and their microenvironment in post-chemotherapy recurrence - Genichiro Ishii; Takahiro Ishii (Human Cell, 2020)

Prevention of Akt phosphorylation is a key to targeting cancer stem-like cells by mTOR inhibition - Shyuichiro Matsubara; Koichiro Tsukasa; Taisaku Kuwahata; Sonshin Takao (Human Cell, 2020)

Establishment and characterization of NCC-GCTB1-C1: a novel patient-derived cancer cell line of giant cell tumor of bone - Rei Noguchi; Yuki Yoshimatsu; Takuya Ono; Akane Sei; Kaoru Hirabayashi; Iwao Ozawa; Kazutaka Kikuta; Tadashi Kondo (Human Cell, 2020)

Regulation and action of interferon-stimulated gene 15 in breast cancer cells - Angeles C. Tecalco-Cruz; Josué O. Ramírez-Jarquín; Eduardo Cruz-Ramos (Human Cell, 2020)

Mesenchymal stem cells and exosome therapy for COVID-19: current status and future perspective - Ashim Gupta; Shivaji Kashte; Manu Gupta; Hugo C. Rodriguez; Shraddha Singh Gautam; Sachin Kadam (Human Cell, 2020)

LncRNA NFIA-AS2 promotes glioma progression through modulating the miR-655-3p/ZFX axis - Jun Xin; Yu-Hong Zhao; Xi-Yun Zhang; Li-Qiang Tian (Human Cell, 2020)

miR-126a-3p targets HIF-1α and alleviates obstructive sleep apnea syndrome with hypertension - Lirong He; Xin Liao; Guofeng Zhu; Jiulong Kuang (Human Cell, 2020)

Mild acidity likely accelerates the physiological matriptase autoactivation process: a comparative study between spontaneous and acid-induced matriptase zymogen activation - Bailing Jia; Hamishi A. Thompson; Robert B. Barndt; Yi-Lin Chiu; Mon-Juan Lee; See-Chi Lee; Jehng-Kang Wang; Hung-Jen Tang; Chen-Yong Lin; Michael D. Johnson (Human Cell, 2020)

GalNAc-T3 and MUC1, a combined predictor of prognosis and recurrence in solitary pulmonary adenocarcinoma initially diagnosed as malignant solitary pulmonary nodule (≤ 3 cm) - Qiang Xie; Fengzhou Li; Shilei Zhao; Tao Guo; Zhuoshi Li; Lei Fang; Shiqing Wang; Wenzhi Liu; Chundong Gu (Human Cell, 2020)

LncRNA DDX11-AS1: a novel oncogene in human cancer - Yubin Feng; Maomao Wu; Shuang Hu; Xiaoqing Peng; Feihu Chen (Human Cell, 2020)

ClC-3 induction protects against cerebral ischemia/reperfusion injury through promoting Beclin1/Vps34-mediated autophagy - Beilin Zhang; Fang Deng; Chunkui Zhou; Shaokuan Fang (Human Cell, 2020)

Enzyme-digested Colla Corii Asini (E’jiao) accelerates wound healing and prevents ultraviolet A-induced collagen synthesis decline and wrinkle formation in three-dimensional skin equivalents - Li Xiao; Feng Liao; Yumei Fan; Nobuhiko Miwa (Human Cell, 2020)

MicroRNA-1469-5p promotes the invasion and proliferation of pancreatic cancer cells via direct regulating the NDRG1/NF-κB/E-cadherin axis - Jinju Liu; Chaoyu Zhu; Lingzhi Zhang; Hongmei Lu; Zhen Wang; Jian Lv; Changru Fan (Human Cell, 2020)

Long noncoding RNA DUXAP8 regulates proliferation and apoptosis of ovarian cancer cells via targeting miR-590-5p - Qingyou Meng; Zhongliang Li; Jiaxue Pan; Xiaorong Sun (Human Cell, 2020)

Establishment and characterization of a novel alveolar rhabdomyosarcoma cell line, NCC-aRMS1-C1 - Yooksil Sin; Yuki Yoshimatsu; Rei Noguchi; Ryuto Tsuchiya; Akane Sei; Takuya Ono; Shunichi Toki; Eisuke Kobayashi; Ayumu Arakawa; Masanaka Sugiyama; Akihiko Yoshida; Akira Kawai; et al. (Human Cell, 2020)

Hydrogen-bubbled platinum-colloid suppresses human esophagus- or tongue-carcinoma cells with intracellular platinum-uptake and the diminished normal-cell mortality - Shinya Kato; Yasukazu Saitoh; Nobuhiko Miwa (Human Cell, 2020)

ERas regulates cell proliferation and epithelial–mesenchymal transition by affecting Erk/Akt signaling pathway in pancreatic cancer - Yang Liu; Peng Qin; Rong Wu; Lianfang Du; Fan Li (Human Cell, 2020)
Pancreatic cancer is the fourth most common lethal malignancy with an overall 5-year survival rate of less than 5%. ERas, a novel Ras family member, was first identified in murine embryonic stem cells and is upregulated in various cancers. However, the expression and potential role of ERas in pancreatic cancer have not been investigated. In this study, we found that ERas mRNA and protein were upregulated in pancreatic cancer tissues and cells compared with controls. Knockdown of ERas in pancreatic cancer cells by siRNA significantly decreased cell proliferation, colony formation, migration, and invasion and promoted cell apoptosis in vitro. Epithelial–mesenchymal transition (EMT) is closely related to tumor progression. We observed a significant decrease in N-cadherin expression in pancreatic cancer cells in response to ERas gene silencing by immunofluorescence assay and western blot. Furthermore, tumor growth and EMT were inhibited in xenografts derived from pancreatic cancer cells with ERas downregulation. We further investigated the regulatory mechanisms of ERas in pancreatic cancer and found that ERas may activate the Erk/Akt signaling pathway. Moreover, Erk inhibitor decreased pancreatic cancer cells proliferation and colony formation activities. Our data suggest that targeting ERas and its relevant signaling pathways might represent a novel therapeutic approach for the treatment of pancreatic cancer.

Prognostic impact of HERC2 protein and pink-eyed dilution protein in uveal melanoma - Seema Kashyap; Mithalesh Kumar Singh; Jayanti Jha; Lata Singh; Neelam Pushker; Seema Sen; Pradeep Venkatesh; Rachna Meel; Neiwete Lomi (Human Cell, 2020)

Overexpression of miR-217-5p protects against oxygen–glucose deprivation/reperfusion-induced neuronal injury via inhibition of PTEN - Zhongquan Yi; Yuanyuan Shi; Panwen Zhao; Yun Xu; Pinglei Pan (Human Cell, 2020)

Correction to: Ectopic PD-L1 expression in JAK2 (V617F) myeloproliferative neoplasm patients is mediated via increased activation of STAT3 and STAT5 - Sameer Ahamd Guru; Mamta P. Sumi; Rashid Mir; Ajaz Ahmad Waza; Musadiq Ahmad Bhat; Mariyam Zuberi; Promod Lali; Alpana Saxena (Human Cell, 2020)

Establishment and characterization of NCC-ASPS1-C1: a novel patient-derived cell line of alveolar soft-part sarcoma - Yuki Yoshimatsu; Rei Noguchi; Ryuto Tsuchiya; Akane Sei; Jun Sugaya; Suguru Fukushima; Akihiko Yoshida; Akira Kawai; Tadashi Kondo (Human Cell, 2020)

Particulate matter exposure promotes Pseudomonas aeruginosa invasion into airway epithelia by upregulating PAFR via the ROS-mediated PI3K pathway - Jinguo Liu; Xiaoyan Chen; Jian Zhou; Ling Ye; Dong Yang; Yuanlin Song (Human Cell, 2020)

Matriptase and prostasin proteolytic activities are differentially regulated in normal and wounded skin - Shun-Cheng Chang; Chien-Ping Chiang; Chih-Hsin Lai; Po-Wen A. Du; Yu-Sin Hung; Yu-Hsuan Chen; Hui-Yu Yang; Hao-Yu Fang; Shiao-Pieng Lee; Hung-Jen Tang; Jehng-Kang Wang; Michael D. Johnson; et al. (Human Cell, 2020)

miR-597-5p inhibits cell growth and promotes cell apoptosis by targeting ELK1 in pancreatic cancer - Shizong Li; Xianglu Li; Xuehua Xing; Lin Wang (Human Cell, 2020)

MiR-96 promotes apoptosis of nucleus pulpous cells by targeting FRS2 - Xiaoxia Yang; Hengping Liu; Qingfeng Zhang; Kan Liu; Dong Yu; Yi Zhang; Zongting Shi (Human Cell, 2020)

KIF15 contributes to cell proliferation and migration in breast cancer - Xiaokang Gao; Linhai Zhu; Xuan Lu; Ying Wang; Ruiqing Li; Guoqin Jiang (Human Cell, 2020)

CCL19 suppresses gastric cancer cell proliferation, migration, and invasion through the CCL19/CCR7/AIM2 pathway - Rui Zhou; Jun Sun; Chunping He; Chao Huang; Honggang Yu (Human Cell, 2020)

Retraction Note to: miR-376a inhibits the proliferation and invasion of osteosarcoma by targeting FBXO11 - Qiaolong Xu; Li Cheng; Jianyang Chen; Wenjie Lu; Peinian Wang (Human Cell, 2020)

Current status and perspectives of patient-derived rare cancer models - Tadashi Kondo (Human Cell, 2020)

Letter to the editor regarding the article ‘MiR-216a alleviates LPS-induced acute lung injury via regulating JAK2/STAT3 and NF-қB signaling’ - Zheng-Ying Jiang; Xin-Cheng Liao; Lian Zhang; Guang-Hua Guo (Human Cell, 2020)

MiR-645 regulates the proliferation and apoptosis of diffuse large B-cell lymphoma by targeting DACH1 - Ruihuan Wang; Jie Shen; Na Su; Qing Wang; Minjuan Zhang; Chunyan Liu (Human Cell, 2020)

HDAC inhibitors promote pancreatic stellate cell apoptosis and relieve pancreatic fibrosis by upregulating miR-15/16 in chronic pancreatitis - Ting Ji; Weiguang Feng; Xiangcheng Zhang; Kui Zang; Xingxing Zhu; Futai Shang (Human Cell, 2020)
In chronic pancreatitis, PSCs are activated by proinflammatory cytokines to induce pancreatic fibrogenesis. HDAC inhibition protected against the pancreatic fibrosis and the apoptosis of PSCs through induced apoptosis and depressed inflammation. In our study, we found that miR-15 and miR-16 decreased significantly in chronic pancreatitis and HDAC inhibition could recover the levels of these two miRNAs. HDAC regulated the transcription of miR-15 and miR-16, which then modulate the apoptosis and fibrosis of PSCs. And we proved that Bcl-2 and Smad5 were the target genes of miR-15 and miR-16, which illustrated how HDAC inhibition alleviated the apoptosis and fibrogenesis of PSCs in chronic pancreatitis. These results suggested that HDAC inhibition protects against CP by promoting apoptosis and TGF-β/Smads signaling pathways, and indicated that HDAC inhibition is a potential therapy to alleviate CP patients in clinic, and these need to be explored further.

Development of a novel insulin receptor (IR) antagonist that exhibits anti-breast tumor activity - Kuang Wenbin; Liu Xiaoqin; Deng Qiuchan; Zheng Xinwen; Xiao Xiaoqin; Shen Fangyuan; He Dabao; Zhu Shuangjiu (Human Cell, 2020)

Clinical relevance of tumor microenvironment: immune cells, vessels, and mouse models - Eriko Katsuta; Omar M. Rashid; Kazuaki Takabe (Human Cell, 2020)

microRNA-4270-5p inhibits cancer cell proliferation and metastasis in hepatocellular carcinoma by targeting SATB2 - Yun Wang; Chang-feng Li; Li-bo Sun; Yong-chao Li (Human Cell, 2020)

Characterization and comparative DNA methylation profiling of four adipogenic genes in adipose-derived stem cells and dedifferentiated fat cells from aging subjects - Kallapat Tansriratanawong; Isao Tabei; Hiroshi Ishikawa; Akihiro Ohyama; Junko Toyomura; Soh Sato (Human Cell, 2020)
Adipose-derived stem cells (ASCs) and dedifferentiated fat (DFAT) cells are alternative cell sources in tissue engineering and regeneration because they are easily obtained and exhibit multilineage differentiation. However, aging may attenuate their regenerative potential and metabolic functions. Reports characterizing DFAT cells derived from aging donors are rare, and comparisons of DNA methylation profiles between aging ASCs and DFAT cells are poorly understood. Therefore, this study aimed to characterize DFAT cells relative to ASCs derived from aging subjects and compare the DNA methylation profiles of four adipogenic genes in these cells. ASCs and DFAT cells from aging donors exhibited characteristics similar to those of stem cells, including colony formation, proliferation, and multilineage differentiation abilities. However, compared with ASCs, DFAT cells exhibited increased proliferation, smooth muscle actin alpha (SMA-α) expression and decreased cellular senescence. DNA methylation profiling of ASCs and DFAT cells by combined bisulfite restriction analysis (COBRA) demonstrated hypermethylation patterns in three potent adipogenic genes—peroxisome proliferator-activated receptor gamma 2 (PPARγ2), fatty acid-binding protein 4 (FABP4), and lipoprotein lipase (LPL)—but hypomethylation of CCAAT/enhancer binding protein alpha (C/EBPα) in the aging group. Statistically significant differences were observed between the aging group and the young group. Epigenetic regulation maintains the stability of ASCs and DFAT cells in an age-dependent manner. Our findings suggested that although the DNA methylation patterns of three adipogenic genes correlated with hypermethylation and aging, ASCs and DFAT cells exhibited cellular stability and several stem cell characteristics, offering further opportunities for personalized regeneration and energy maintenance by adipogenesis during aging.

Ectopic PD-L1 expression in JAK2 (V617F) myeloproliferative neoplasm patients is mediated via increased activation of STAT3 and STAT5 - Sameer Ahamd Guru; Mamta P. Sumi; Rashid Mir; Ajaz Ahmad Waza; Musadiq Ahmad Bhat; Mariyam Zuberi; Promod Lali; Alpana Saxena (Human Cell, 2020)

RETRACTED ARTICLE: LINC00665/miR-9-5p/ATF1 is a novel axis involved in the progression of colorectal cancer - Xuhong Zhao; Wenhao Weng; Yin Long; Weijie Pan; Zhi Li; Fenyong Sun (Human Cell, 2020)

A development strategy to fast establish the Taqman qPCR based method to detect SNP mutations - Xiaohui Jiang; Junbei Xiang; Ruifeng Wang; Qian Wan (Human Cell, 2020)

Investigation of the effects of urea cycle amino acids on the expression of ALB and CEBPB in the human hepatocellular carcinoma cell line FLC-4 - Takahiko J. Fujimi; Yoshihiro Mezaki; Takahiro Masaki; Ayasa Tajima; Mariko Nakamura; Akira Yoshikawa; Noriyuki Murai; Mamoru Aizawa; Soichi Kojima; Yoshihiro Matsumoto; Hideki Aizaki; Tomokazu Matsuura (Human Cell, 2020)
Cell lines are powerful tools for research into liver function at the molecular level. However, they are generally unsuitable for rigorously assessing the effects of amino acid composition, because many lines require serum-containing medium for their maintenance. Here, we aimed to investigate the effects of ornithine and arginine, which are included in the characteristic metabolic process in hepatocyte, on a human hepatoma-derived cell line (FLC-4) that can be cultured in serum-free medium. FLC-4 cells were cultured under the following three conditions: + ornithine/ – arginine, – ornithine/ – arginine, and –ornithine/ + arginine. Albumin expression evaluated by quantitative polymerase chain reaction and enzyme-linked immunosorbent assay and showed no obvious differences based on the presence of ornithine or arginine. However, the mRNA levels of two liver-enriched transcription factors ( CEBPB and HNF1A ), which are involved in regulating albumin expression, were significantly higher in cells grown in medium-containing arginine than that in cells grown in ornithine-containing medium. Western blotting showed that the levels both activating and inhibitory C/EBPβ isoforms were significantly increased in cells grown in arginine medium. Furthermore, we have found that depletion of both ornithine and arginine, the polyamine sources, in the medium did not cause polyamine deficiency. When ornithine and arginine were depleted, albumin production was significantly reduced at the mRNA level, CEBPB mRNA levels were increased, and the level of activating form of C/EBPβ was increased. The results of this study suggest that in hepatocyte, these two amino acids might have different functions, and because of which they elicit disparate cellular responses.

Interleukin-22 enhances chemoresistance of lung adenocarcinoma cells to paclitaxel - Zhiliang Huang; Yu Gao; Dianchen Hou (Human Cell, 2020)

Exosomes derived from natural killer cells inhibit hepatic stellate cell activation and liver fibrosis - Ling Wang; Yinghao Wang; Jun Quan (Human Cell, 2020)

Biological assessment of new tetrahydroacridine derivatives with fluorobenzoic moiety in vitro on A549 and HT-29 cell lines and in vivo on animal model - Karol Kłosiński; Małgorzata Girek; Kamila Czarnecka; Zbigniew Pasieka; Robert Skibiński; Paweł Szymański (Human Cell, 2020)
A new series of tetrahydroacridine derivatives with the fluorobenzoyl moiety was synthesized and evaluated for cytotoxic activity against lung cancer cell lines A549 and colorectal cancer HT29. The cytotoxic activity of the compounds was compared on the somatic cell line—EAhy926. Compounds showed high cytotoxic activity on A549 cells (IC 50 183.26–68.07 μM) and HT29 cells (IC 50 68.41–19.70 μM), higher than controls—etoposide (IC 50 451.47 μM) toward A549 and 5-fluorouracil (IC 50 1626.85 μM) against HT29. Derivative 4 was the most cytotoxic to A549, whereas for the cell lines HT29 compound 6 . Selected compounds showed similar cytotoxicity to the EAhy926 cell line (IC 50 about 50 μM). In the hyaluronidase inhibition assay, all compounds exhibited anti-inflammatory activity, including 4 exhibiting the best inhibitory activity—IC 50 of 52.27 μM when the IC 50 heparin was 56.41 μM. Mathematical modeling was performed to determine LD 50 after intraperitoneal, oral, intravenous and subcutaneous administration and to predict potential mutagenicity and carcinogenicity of the compounds analyzed. Obtained results showed that tested derivatives are slightly toxic compounds, and LD 50 values (mg/kg) ranged from 680 to 1200 (oral rat model), the analyzed compounds have low mutagenic potential, and differences between derivatives are insignificant and very low probability of carcinogenicity. To confirm mathematical calculations, an in vivo test was carried out on a laboratory mouse model for two selected compounds. It allowed to qualify compounds: 6 to category 4 of the GHS scale, and 4 to category 3 of the GHS scale.

LncRNA HCG18 is critical for vascular smooth muscle cell proliferation and phenotypic switching - Yanjiao Lu; Jingjing Guo; Shengnan Zhu; Han Zhang; Qing Zhu; Yanming Li (Human Cell, 2020)

Progress in the treatment of osteoarthritis with umbilical cord stem cells - Hanguang Liang; Haiqiang Suo; Zhiwei Wang; Wei Feng (Human Cell, 2020)
Osteoarthritis is a chronic degenerative joint disease with an incidence of 81% among people aged over 65 years in China. Osteoarthritis significantly decreases the quality of life of patients, causing physical and psychological damage and posing a serious economic burden. Clinical treatments for osteoarthritis include drug and surgical treatments. Drug treatment can successfully alleviate pain but not satisfactorily reverse joint damage, while surgical intervention is typically used to treat end-stage disease. Stem cells are multi-potential progenitor cells with self-renewal and multi-lineage differentiation abilities, and can differentiate into many kinds of cells, including chondrocytes. Umbilical cord stem cells, also known as Wharton’s jelly mesenchymal stem cells (WJ-MSCs), have become the first choice for cartilage regeneration engineering owing to their availability and convenience of collection. This article reviews the biological characterization of WJ-MSCs in recent years, their advantages compared with other stem cells, and their application in the treatment of osteoarthritis in animal experiments and clinical trials.

Tricyclic antipsychotics promote adipogenic gene expression to potentiate preadipocyte differentiation in vitro - Christopher M. Cottingham; Taylor Patrick; Morgan A. Richards; Kirkland D. Blackburn (Human Cell, 2020)

Study of the MDM2 -410T-G polymorphism (rs2279744) by pyrosequencing in mothers of Down Syndrome subjects - Michele Salemi; Maria Grazia Salluzzo; Concetta Barone; Corrado Romano (Human Cell, 2020)

MiR-27b-3p exerts tumor suppressor effects in esophageal squamous cell carcinoma by targeting Nrf2 - Mei Han; Na Li; Fanzhou Li; Hua Wang; Lanying Ma (Human Cell, 2020)

Maspin suppresses cell invasion and migration in gastric cancer through inhibiting EMT and angiogenesis via ITGB1/FAK pathway - Ning Wang; Li-Li Chang (Human Cell, 2020)

miR-1224-5p inhibits the proliferation and invasion of ovarian cancer via targeting SND1 - Junrong Wang; Yubo Hu; Cong Ye; Junbao Liu (Human Cell, 2020)

GATA3 and stemness of high-grade serous ovarian carcinoma: novel hope for the deadliest type of ovarian cancer - Amr Ahmed El-Arabey; Mohnad Abdalla; Adel Rashad Abd-Allah (Human Cell, 2020)

TRAF4 knockdown triggers synergistic lethality with simultaneous PARP1 inhibition in endometrial cancer - Liulin Tang; Min Wang; Li Jiang; Chengying Zeng (Human Cell, 2020)

A combination of four serum miRNAs for screening of lung adenocarcinoma - Jingyao Wang; Chunduo Zhang; Xiqi Peng; Kaihao Liu; Liwen Zhao; Xuan Chen; Hongjian Yu; Yongqing Lai (Human Cell, 2020)

Interplay between mesenchymal stem cell and tumor and potential application - Qing Wang; Ti Li; Wei Wu; Gang Ding (Human Cell, 2020)

Establishment and characterization of NCC-DFSP3-C1: a novel patient-derived dermatofibrosarcoma protuberans cell line - Yuki Yoshimatsu; Rei Noguchi; Ryuto Tsuchiya; Akane Sei; Makoto Nakagawa; Akihiko Yoshida; Akira Kawai; Tadashi Kondo (Human Cell, 2020)

Gastric-cancer-derived mesenchymal stem cells: a promising target for resveratrol in the suppression of gastric cancer metastasis - Lei Yin; Rongxue Zhang; Yuyan Hu; Wenhao Li; Maoye Wang; Zhaofeng Liang; Zixuan Sun; Runbi Ji; Wenrong Xu; Hui Qian (Human Cell, 2020)

MicroRNA-153-3p enhances the sensitivity of chronic myeloid leukemia cells to imatinib by inhibiting B-cell lymphoma-2-mediated autophagy - Yu-Ling Li; Jia-Ming Tang; Xiao-Yun Chen; Bing Luo; Guo-Hua Liang; Qian Qu; Zi-Yuan Lu (Human Cell, 2020)

SDC1 promotes cisplatin resistance in hepatic carcinoma cells via PI3K-AKT pathway - Liquan Yu; Hong Xu; Song Zhang; Jiangming Chen; Zhongshan Yu (Human Cell, 2020)

The spatiotemporal control of human matriptase action on its physiological substrates: a case against a direct role for matriptase proteolytic activity in profilaggrin processing and desquamation - Chen-Yong Lin; Jehng-Kang Wang; Michael D. Johnson (Human Cell, 2020)

AGR2-induced glucose metabolism facilitated the progression of endometrial carcinoma via enhancing the MUC1/HIF-1α pathway - Wei Gong; Belize Ekmu; Xinmei Wang; Yanli Lu; Li Wan (Human Cell, 2020)

Establishment and characterization of NCC-ssRMS1-C1: a novel patient-derived spindle-cell/sclerosing rhabdomyosarcoma cell line - Yuki Yoshimatsu; Rei Noguchi; Ryuto Tsuchiya; Akane Sei; Jun Sugaya; Shintaro Iwata; Masanaka Sugiyama; Akihiko Yoshida; Akira Kawai; Tadashi Kondo (Human Cell, 2020)

Effect of the extracellular component of bone marrow mesenchymal stromal cells from healthy donors on hematologic neoplasms and their angiogenesis - Nina Gladkova; Tomohiro Umezu; Satoshi Imanishi; Chiaki Kawana; Junko H. Ohyashiki; Kazuma Ohyashiki (Human Cell, 2020)
Bone marrow mesenchymal stromal cells (BM-MSCs) from healthy donors are a promising source of cell therapy. However, their effectiveness in cancer remains less known. This study is the first to evaluate the quality of BM-MSCs obtained from young and elderly healthy volunteers (KNT cells). The KNT cells had normal karyotypes and were positive for MSC markers (CD90, CD73, CD105). When cultured under appropriate conditions, they showed adipogenic or osteogenic potential. Hence, the anti-neoplastic effects of secretory factors [supernatant or extracellular vesicles (EV)] from KNT cells were verified using several neoplastic cells (three multiple myeloma, three myeloid leukemia, and three lymphoma cell lines). The conditioned medium (CM), but not EV, of KNT cells derived from young healthy donors significantly inhibited myeloma and lymphoma cell proliferation, but enhanced myeloid leukemia proliferation. Anti-angiogenesis effect of CM and EV derived from young KNT against hematologic neoplasia-induced angiogenesis was evident and more prominent in CM than in EV but not evident in elderly KNT-derived EV. These findings indicate that the anti-tumor effect of KNT cells depends on the types of hematologic neoplasia, with elements existing in the supernatant and not in EVs. Therefore, BM-MSC may produce soluble factors that affect cell proliferation of neoplasia, causing cell-to-cell communication. The anti-angiogenesis effect of KNT cells depends on the age of BM-MSC donors.

The miR-590-3p/VEGFA axis modulates secretion of VEGFA from adipose-derived stem cells, which acts as a paracrine regulator of human dermal microvascular endothelial cell angiogenesis - Yang Sun; Xiang Xiong; Xiancheng Wang (Human Cell, 2020)

MiR-206 suppresses proliferation and epithelial-mesenchymal transition of renal cell carcinoma by inhibiting CDK6 expression - Zhen Guo; Haiyan Jia; Junke Ge (Human Cell, 2020)

Circular RNA hsa_circ_0002052 promotes osteosarcoma via modulating miR-382/STX6 axis - Ping-rong Zhang; Jing Ren; Jian-shan Wan; Rong Sun; Ying Li (Human Cell, 2020)

StarD13: a potential star target for tumor therapeutics - Leila Jaafar; Zeinab Chamseddine; Mirvat El-Sibai (Human Cell, 2020)

Establishment and characterization of NCC-SS3-C1: a novel patient-derived cell line of synovial sarcoma - Yuki Yoshimatsu; Rei Noguchi; Ryuto Tsuchiya; Akane Sei; Jun Sugaya; Shintaro Iwata; Akihiko Yoshida; Akira Kawai; Tadashi Kondo (Human Cell, 2020)

MiR-186 represses progression of renal cell cancer by directly targeting CDK6 - Zhen Guo; Xianbao Lv; Haiyan Jia (Human Cell, 2020)

miR-140-3p aggregates osteoporosis by targeting PTEN and activating PTEN/PI3K/AKT signaling pathway - Ruofeng Yin; Jiajia Jiang; Huimin Deng; Zhaobin Wang; Rui Gu; Fei Wang (Human Cell, 2020)

MicroRNA-223-5p targets long non-coding RNA TP73 antisense RNA1 to promote the invasion of gastric cancer - Junhui Liu; Haijiang Wang; Xinhua Liao (Human Cell, 2020)

Differential expression of circulating serum miR-1249-3p, miR-3195, and miR-3692-3p in non-small cell lung cancer - Sachin Kumar; Surender K. Sharawat; Ashraf Ali; Vikas Gaur; Prabhat Singh Malik; Monu Pandey; Sunil Kumar; Anant Mohan; Randeep Guleria (Human Cell, 2020)

SNHG16 regulates invasion and migration of bladder cancer through induction of epithelial-to-mesenchymal transition - Wenwei Chen; Tao Jiang; Houping Mao; Rui Gao; Hua Zhang; Yanfeng He; Changyi Liu; Qin Chen (Human Cell, 2020)

Functional and genetic characterization of three cell lines derived from a single tumor of an Opisthorchis viverrini-associated cholangiocarcinoma patient - Banchob Sripa; Wunchana Seubwai; Kulthida Vaeteewoottacharn; Kanlayanee Sawanyawisuth; Atit Silsirivanit; Worasak Kaewkong; Kanha Muisuk; Paweena Dana; Chatchai Phoomak; Worachart Lert-itthiporn; Vor Luvira; Chawalit Pairojkul; et al. (Human Cell, 2020)

Candesartan ameliorates vascular smooth muscle cell proliferation via regulating miR-301b/STAT3 axis - Ling Zhang; Fan Yang; Qiong Yan (Human Cell, 2020)

Characterization of proliferation, differentiation potential, and gene expression among clonal cultures of human dental pulp cells - Tomoko Kobayashi; Daisuke Torii; Takanori Iwata; Yuichi Izumi; Masanori Nasu; Takeo W. Tsutsui (Human Cell, 2020)
Mesenchymal stem cells are a highly promising source of cells for regeneration therapy because of their multilineage differentiation potential. However, distinct markers for mesenchymal stem cells are not well-established. To identify new candidate marker genes for multipotent human dental pulp stem cells, we analyzed the characteristics and gene expression profiles of cell clones obtained from a single dental pulp specimen derived from an 11-year-old female patient. Fifty colony-forming single cell-derived clones were separately cultured until the cessation of growth. These clones varied in their proliferation abilities and surface marker (STRO-1 and CD146) expression patterns, as well as their odontogenic, adipogenic, and chondrogenic differentiation potentials. Four clones maintained their original differentiation potentials during long-term culture. Gene expression profile by DNA microarray analysis of five representative clones identified 1227 genes that were related to multipotency. Ninety of these 1227 genes overlapped with genes reportedly involved in ‘stemness or differentiation’. Based on the predicted locations of expressed protein products and large changes in expression levels, 14 of the 90 genes were selected as candidate dental pulp stem cell markers, particularly in relation to their multipotency characteristics. This characterization of cell clones obtained from a single specimen of human dental pulp provided information regarding new candidate marker genes for multipotent dental pulp stem cells, which could facilitate efficient analysis or enrichment of multipotent stem cells.

Dysfunctional ABCG2 gene polymorphisms are associated with serum uric acid levels and all-cause mortality in hemodialysis patients - Akio Nakashima; Kimiyoshi Ichida; Ichiro Ohkido; Keitaro Yokoyama; Hirotaka Matsuo; Yuki Ohashi; Tappei Takada; Akiyoshi Nakayama; Hiroshi Suzuki; Nariyoshi Shinomiya; Mitsuyoshi Urashima; Takashi Yokoo (Human Cell, 2020)
Dysfunctional variants of ATP-binding cassette transporter subfamily G member 2 (ABCG2), a urate transporter in the kidney and intestine, are the major causes of hyperuricemia and gout. A recent study found that ABCG2 is a major transporter of uremic toxins; however, few studies have investigated the relationship between ABCG2 gene polymorphisms and mortality. This prospective cohort study of 1214 hemodialysis patients investigated the association between serum uric acid levels and ABCG2 genotype and mortality. Genotyping of dysfunctional ABCG2 variants, Q126X (rs72552713) and Q141K (rs2231142), was performed using the patients’ DNA. During the study period, 220 patients died. Lower serum uric acid levels were associated with higher mortality (hazard ratio [HR] 1.89, 95% confidence interval [CI] 1.14–3.10, P ≤ 0.001). ABCG2 dysfunction, estimated by genetic variants, had a significant positive association with serum uric acid levels (full function: 7.4 ± 1.2 mg/dl, 3/4 function: 7.9 ± 1.3 mg/dl, 1/2 function: 8.2 ± 1.4 mg/dl, ≤ 1/4 function: 8.7 ± 1.3 mg/dl, P ≤ 0.001). This association remained significant on multiple regression analysis. The Cox proportional hazard analysis indicated that the ABCG2 ≤ 1/4 function type was significantly associated with higher mortality (HR 6.66, 95% CI 2.49 to 17.8, P ≤ 0.001) than the other function types. These results showed that ABCG2 plays a physiologically important role in uric acid excretion, and that ABCG2 dysfunction is a risk factor for mortality in hemodialysis patients.

Kasumi leukemia cell lines: characterization of tumor genomes with ethnic origin and scales of genomic alterations - Fumio Kasai; Hiroya Asou; Midori Ozawa; Kazuhiko Kobayashi; Hiroyuki Kuramitsu; Motonobu Satoh; Arihiro Kohara; Yasuhiko Kaneko; Machiko Kawamura (Human Cell, 2020)
Kasumi-1 has played an important role in an experimental model with t(8;21) translocation, which is a representative example of leukemia cell lines. However, previous studies using Kasumi-1 show discrepancies in the genome profile. The wide use of leukemia cell lines is limited to lines that are well-characterized. The use of additional cell lines extends research to various types of leukemia, and to further explore leukemia pathogenesis, which can be achieved by uncovering the fundamental features of each cell line with accurate data. In this study, ten Kasumi cell lines established in Japan, including five that were previously unknown, have been characterized by SNP microarray and targeted sequencing. SNP genotyping suggested that the genetic ancestry in four of the ten Kasumi cell lines was not classified as Japanese but covered several different east-Asian ethnicities, suggesting that patients in Japan are genetically diverse. TP53 mutations were detected in two cell lines with complex array profiles, indicating chromosomal instability (CIN). A quantitative assessment of tumor genomes at the chromosomal level was newly introduced to reveal total DNA sizes and Scales of Genomic Alterations (SGA) for each cell line. Kasumi-1 and 6 derived from relapsed phases demonstrated high levels of SGA, implying that the level of SGA would reflect on the tumor progression and could serve as an index of CIN. Our results extend the leukemia cellular resources with an additional five cell lines and provide reference genome data with ethnic identities for the ten Kasumi cell lines.

Fertilization with human sperm bound to zona pellucida by pressing onto the oocyte membrane - Shota Hatakeyama; Yasuyuki Araki; Shirei Ohgi; Atsushi Yanaihara; Yasuhisa Araki (Human Cell, 2020)

Nck1 promotes the progression of ovarian carcinoma by enhancing the PI3K/AKT/p70S6K signaling - Xiaohan Liu; Jing Zhang; Zhaoning Duan; Xiushan Feng; Yang Yu; Min He; Liangdan Tang (Human Cell, 2020)

Long noncoding RNA LINC00520 accelerates the progression of colorectal cancer by serving as a competing endogenous RNA of microRNA-577 to increase HSP27 expression - Xi-Han Jin; Yong-Gang Hong; Peng Li; Li-Qiang Hao; Ming Chen (Human Cell, 2020)

Chemopreventive effects of nanoparticle curcumin in a mouse model of Pten-deficient prostate cancer - Marco A. De Velasco; Yan Lu; Yurie Kura; Toshiyuki China; Yasuyuki Inoue; Akinori Nakayama; Hiroshi Okada; Shigeo Horie; Hirotsugu Uemura; Hisamitsu Ide (Human Cell, 2020)

Thyroid-related hormones as potential markers of hypoxia/ischemia - Naoto Tani; Mayumi Ishikawa; Miho Watanabe; Tomoya Ikeda; Takaki Ishikawa (Human Cell, 2020)
This study aimed to investigate the usefulness of the thyroid-related hormones as markers of acute systemic hypoxia/ischemia to identify deaths caused by asphyxiation due to neck compression in human autopsy cases. The following deaths from pathophysiological conditions were examined: mechanical asphyxia and acute/subacute blunt head injury; acute/subacute non-head blunt injury; sharp instrument injury as the hemorrhagic shock condition; drowning as alveolar injury; burn; and death due to cardiac dysfunction. Blood samples were collected from the left and right cardiac chambers and iliac veins, and serum triiodothyronine (T3), thyroxine (T4), thyroglobulin (Tg), and thyroid-stimulating hormone (TSH) levels were measured using electrochemiluminescence immunoassays. Two types of thyroid cell lines were used to confirm independent thyroid function under the condition of hypoxia (3% O 2 ). The human thyroid carcinoma cell line (HOTHC) cell line derived from human anaplastic thyroid carcinoma and the UD-PTC (sample of the second resection papillary thyroid carcinoma) cell line derived from human thyroid papillary adenoma, which forms Tg retention follicles, were used to examine the secretion levels of T3, T4, and Tg hormones. The results showed a strong correlation between T3 and T4 levels in all blood sampling sites, while the TSH and Tg levels were not correlated with the other markers. Serum T3 and T4 levels were higher in cases of mechanical asphyxia and acute/subacute blunt head injury, representing hypoxic and ischemic conditions of the brain as compared to those in other causes of death. In the thyroid gland cell line, T4, T3, and Tg levels were stimulated after exposure to hypoxia for 10–30 min. These findings suggest that systemic advanced hypoxia/ischemia may cause a rapid and TSH-independent release of T3 and T4 thyroid hormones in autopsy cases. These findings demonstrate that increased thyroid-related hormone (T3 and T4) levels in the pathophysiological field may indicate systemic hypoxia/ischemia.

MiR-1256 inhibits cell proliferation and cell cycle progression in papillary thyroid cancer by targeting 5-hydroxy tryptamine receptor 3A - Chaowen Wu; Liyuan Ma; Hongfa Wei; Furong Nie; Jie Ning; Tao Jiang (Human Cell, 2020)

Overexpression of tissue factor pathway inhibitor 2 attenuates trophoblast proliferation and invasion in preeclampsia - Lili Zheng; Jing Huang; Yuan Su; Fang Wang; Hongfang Kong; Hong Xin (Human Cell, 2020)

MiR-1297 negatively regulates metabolic reprogramming in glioblastoma via repressing KPNA2 - Huibing Li; Honggang Yuan (Human Cell, 2020)

RETRACTED ARTICLE: Long non-coding RNA MIAT promotes the growth of melanoma via targeting miR-150 - Lifei Zhu; Yexiao Wang; Chaoying Yang; Yanchang Li; Zhixin Zheng; Liangcai Wu; Hui Zhou (Human Cell, 2020)

RETRACTED ARTICLE: RCC2 contributes to tumor invasion and chemoresistance to cisplatin in hepatocellular carcinoma - Qingmin Chen; Peiqiang Jiang; Baoxing Jia; Yahui Liu; Ze Zhang (Human Cell, 2020)

Alpha-mangostin reduces mechanical stiffness of various cells - Thi Kieu Trang Phan; Fahimeh Shahbazzadeh; Takanori Kihara (Human Cell, 2020)

LncRNA GAS5-AS1 inhibits glioma proliferation, migration, and invasion via miR‐106b-5p/TUSC2 axis - Wu Huang; Yu Shi; Bin Han; Qilong Wang; Bin Zhang; Chunjian Qi; Fang Liu (Human Cell, 2020)

Long non-coding RNA NEAT1 promotes colorectal cancer progression by regulating miR-205-5p/VEGFA axis - Huijie Liu; Aiyi Li; Zhichao Sun; Jingyu Zhang; Hua Xu (Human Cell, 2020)

MicroRNA-498 inhibits the proliferation, migration and invasion of gastric cancer through targeting BMI-1 and suppressing AKT pathway - Dong You; Dawei Wang; Peiji Liu; Yuning Chu; Xueying Zhang; Xueli Ding; Xiaoyu Li; Tao Mao; Xue Jing; Zibin Tian; Yinghua Pan (Human Cell, 2020)

Differentiation of human umbilical cord mesenchymal stem cells into Leydig-like cells with defined molecular compounds - Weiping Ji; Yong Chen; Long Wang; Zhangye Xu; Jahanzeb Ahmed; Renshan Ge; Maoping Chu; Xiaoling Guo (Human Cell, 2020)

Multi-lineage differentiation and clinical application of stem cells from exfoliated deciduous teeth - Fei Xie; Jie He; Yingyi Chen; Ziqi Hu; Man Qin; Tianqian Hui (Human Cell, 2020)

A common variant of LDL receptor related protein 2 (LRP2) gene is associated with gout susceptibility: a meta-analysis in a Japanese population - Airi Akashi; Akiyoshi Nakayama; Yoichiro Kamatani; Toshihide Higashino; Seiko Shimizu; Yusuke Kawamura; Misaki Imoto; Mariko Naito; Asahi Hishida; Makoto Kawaguchi; Mikiya Takao; Michinori Matsuo; et al. (Human Cell, 2020)
Gout, which results from elevated serum uric acid (SUA), is a common form of arthritis that is induced by urate crystals. A single nucleotide polymorphism, rs2544390, of LDL receptor related protein 2 ( LRP2/Megalin ), has previously been reported to be associated with SUA by a genome-wide association study in a Japanese population. However, it was controversial as to whether rs2544390 is associated with gout in a Japanese population, since previous studies with Japanese populations have reported an association between gout and rs2544390 both with and without significance. This prompted us to investigate the association between gout and rs2544390 of LRP2. Using 1208 clinically diagnosed gout patients and 1223 controls in a Japanese male population, our results showed that while rs2544390 did not show a significant association with gout susceptibility in the present study ( p = 0.0793, odds ratio [OR] with 95% confidential interval [CI] 1.11 [0.99–1.24]). However, a meta-analysis using previous studies on Japanese populations revealed a significant association with gout ( p meta = 0.0314, OR with 95% CI 1.09 [1.01–1.18]). We have therefore for the first time confirmed a positive association between rs2544390 and gout with only a Japanese male population. Our study provides clues to a better understanding of the pathogenesis of gout and has the potential to lead to novel therapeutic strategies against gout using LRP2 as a molecular target.

Comparative phenotypic characterization of human colostrum and breast milk-derived stem cells - Nasim Goudarzi; Ronak Shabani; Marzieh Ebrahimi; Amir Baghestani; Ehsan Dehdashtian; Gelareh Vahabzadeh; Mansoure Soleimani; Fatemeh Moradi; Majid Katebi (Human Cell, 2020)

Silibinin enhances anti-renal fibrosis effect of MK-521 via downregulation of TGF-β signaling pathway - Zhongchao Ma; Wenwen Zang; Huaiguo Wang; Xiaojing Wei (Human Cell, 2020)

Comparison of cytologic findings between specimens with and without high-risk HPV infection in those with ASC-US judgement - Hiroyuki Kuramoto; Midori Banno; Naoko Sugimoto; Takashi Sugahara; Chizuyo Kato; Masuko Hori; Akihiro Kimura (Human Cell, 2020)

miR-362-5p promotes cell proliferation and cell cycle progression by targeting GAS7 in acute myeloid leukemia - Fuqun Wu; Changxin Yin; Junhua Qi; Deyu Duan; Xi Jiang; Jianhua Yu; Zhaofan Luo (Human Cell, 2020)
Recently, miR-362-5p has attracted special interest as a novel prognostic predictor in acute myeloid leukemia (AML). However, its biological function and underlying molecular mechanism in AML remain to be further defined. Herein, we found that a significant increase in miR-362-5p expression was observed in AML patients and cell lines using quantitative real-time PCR. The expression of miR-362-5p was altered in THP-1 and HL-60 cells by transfecting with miR-362-5p mimic or inhibitor. A series of experiments showed that inhibition of miR-362-5p expression significantly suppressed cell proliferation, induced G0/G1 phase arrest and attenuated tumor growth in vivo. On the contrary, ectopic expression of miR-362-5p resulted in enhanced cell proliferation, cell cycle progression and tumor growth. Moreover, growth arrest-specific 7 (GAS7) was confirmed as a direct target gene of miR-362-5p and was negatively modulated by miR-362-5p. GAS7 overexpression imitated the tumor suppressive effect of silenced miR-362-5p on THP-1 cells. Furthermore, miR-362-5p knockdown or GAS7 overexpression obviously down-regulated the expression levels of PCNA, CDK4 and cyclin D1, but up-regulated p21 expression. Collectively, our findings demonstrate that miR-362-5p exerts oncogenic effects in AML by directly targeting GAS7, which might provide a promising therapeutic target for AML.

PAK1 silencing is synthetic lethal with CDK4/6 inhibition in gastric cancer cells via regulating PDK1 expression - Yan Qian; Xu Wu; Haixiao Wang; Guowei Hou; Xiao Han; Wei Song (Human Cell, 2020)

Establishment and characterization of NCC-CDS2-C1: a novel patient-derived cell line of CIC-DUX4 sarcoma - Yuki Yoshimatsu; Rei Noguchi; Ryuto Tsuchiya; Fusako Kito; Akane Sei; Jun Sugaya; Makoto Nakagawa; Akihiko Yoshida; Shintaro Iwata; Akira Kawai; Tadashi Kondo (Human Cell, 2020)

PTK7 promotes the malignant properties of cancer stem-like cells in esophageal squamous cell lines - Jun Bie; Xin Hu; Mi Yang; Xianwei Shi; Xinping Zhang; Ziwei Wang (Human Cell, 2020)

RETRACTED ARTICLE: Downregulation of miR-96 suppresses the profibrogenic functions of cardiac fibroblasts induced by angiotensin II and attenuates atrial fibrosis by upregulating KLF13 - Lijie Su; Yili Yao; Wei Song (Human Cell, 2020)

MiR-490-5p functions as tumor suppressor in childhood neuroblastoma by targeting MYEOV - Jinfeng Wang; Xin Zhang; Hongyue Yao; Yuan Le; Wei Zhou; Jing Li; Lingling Lu; Meixue Chen; Xiang Li (Human Cell, 2020)

Patterns of immune infiltration in lung adenocarcinoma revealed a prognosis-associated microRNA–mast cells network - Chunlin Wang; Xi Tang; Jiaojian Wang; Yanhua Xu (Human Cell, 2020)

A new method to identify fetal sex and trisomy 21 from the amniocentesis of pregnant women - Junbei Xiang; Qian Wan; Mianxue Liu; Ruifeng Wang (Human Cell, 2020)

miR-29b inhibits non-small cell lung cancer progression by targeting STRN4 - Yuping Xie; Fen Zhao; Ping Zhang; Ping Duan; Yangmei Shen (Human Cell, 2020)

Increased in vitro migration of human umbilical cord mesenchymal stem cells toward acellular foreskin treated with bacterial derivatives of monophosphoryl lipid A or supernatant of Lactobacillus acidophilus - Ali Shojaeian; Ameneh Mehri-Ghahfarrokhi; Mehdi Banitalebi-Dehkordi (Human Cell, 2020)

Correction to: Gene expression and DNA methylation changes in BeWo cells dependent on tumor necrosis factor-α and insulin-like growth factor-I - Kei Tanaka; Kazuhiko Nakabayashi; Tomoko Kawai; Shinji Tanigaki; Kenji Matsumoto; Kenichiro Hata; Yoichi Kobayashi (Human Cell, 2020)

Integrins expressed on the surface of human endometrial stromal cells derived from a female patient experiencing spontaneous abortion - Jie Ohn Sohn; Hye Jin Park; Se Hee Kim; Min Ji Kim; Hyun Jin Song; Jung Im Yun; Jeong Mook Lim; Seung Tae Lee (Human Cell, 2020)

MiR-216a alleviates LPS-induced acute lung injury via regulating JAK2/STAT3 and NF-κB signaling - Fanpo Kong; Yanqi Sun; Wenke Song; Yongqin Zhou; Siliang Zhu (Human Cell, 2020)

Spermatogenesis-associated changes of fucosylated glycolipids in murine testis - Masao Iwamori; Shigeki Adachi; Bei Lin; Kyoko Tanaka; Daisuke Aoki; Taisei Nomura (Human Cell, 2020)

Tumor promoting effects of glucagon receptor: a promising biomarker of papillary thyroid carcinoma via regulating EMT and P38/ERK pathways - Hong-Chun Jiang; Xiang-Ru Chen; Hai-Feng Sun; Yuan-Wen Nie (Human Cell, 2020)

Hirsutella sinensis inhibits NLRP3 inflammasome activation to block aristolochic acid-induced renal tubular epithelial cell transdifferentiation - Min Yu; Yu-lin Man; Meng-hua Chen; Li-hua Wu; Yi Zhou; Xiao-ling Zhou; Na Chen; Rui Ma; Li-na Sun (Human Cell, 2020)

LncRNA MYCNOS facilitates proliferation and invasion in hepatocellular carcinoma by regulating miR-340 - Junfeng Yu; Zhejian Ou; Yangyang Lei; Liuhua Chen; Qiao Su; Kunsong Zhang (Human Cell, 2020)

miR-663b promotes colorectal cancer progression by activating Ras/Raf signaling through downregulation of TNK1 - Sen Hong; Zhenkun Yan; Helei Wang; Lei Ding; Yumei Song; Miaomiao Bi (Human Cell, 2020)

Exploring the effect of epigenetic modifiers on developing insulin-secreting cells - Ibrahim Elsharkawi; Divyasree Parambath; Maha Saber-Ayad; Amir Ali Khan; Ahmed T. El-Serafi (Human Cell, 2020)

Risk factors associated with the development of moderate to severe chronic graft-versus-host disease after non-myeloablative conditioning allogeneic stem cell transplantation in patients with AML or MDS - Laurence M. C. Kok; Laura Bungener; Geertruida H. de Bock; Anouschka Biswana; Geertiena van der Wal; Gustaaf W. van Imhoff; Mar Bellido (Human Cell, 2020)
Moderate to severe chronic graft-versus-host disease (cGVHD) is associated with high morbidity, hospital dependency and poor quality of life. In this study, we analyzed a well-defined consecutive series of 98 patients with acute myelogenous leukemia/myelodysplastic syndrome (AML/MDS) who received allogeneic stem cell transplantation with non-myeloablative (NMA) conditioning to determine risk factors associated with the severity of cGVHD. cGVHD was defined according to the 2005 National Institute of Health consensus criteria. Transfusions before transplantation, presence of HLA antibodies, composition of the graft (CD3+, CD19+, CD34+ cells), sibling or matched unrelated donor, female donor to male recipient, CMV serology and the development of acute GVHD (aGVHD), were considered potential risk factors. Multivariate Cox regression analysis identified the number of CD19+ 10 6 /kg (HR 2.79; 95% CI 1.35–5.74), CD3+ 10 6 /kg (HR 2.18; 95% CI 1.04–4.59) infused cells and the presence of patient HLA antibodies before transplantation (HR 2.34; CI 1.11–4.95) as significant risk factors for the development of moderate to severe cGVHD. In summary, we identified in a small, but well-defined cohort, 3 risk factors associated with the severity of cGVHD that should be validated in a larger multi-center study.

Gene expression and DNA methylation changes in BeWo cells dependent on tumor necrosis factor-α and insulin-like growth factor-I - Kei Tanaka; Kazuhiko Nakabayashi; Tomoko Kawai; Shinji Tanigaki; Kenji Matsumoto; Kenichiro Hata; Yoichi Kobayashi (Human Cell, 2020)

LINC00174 down-regulation decreases chemoresistance to temozolomide in human glioma cells by regulating miR-138-5p/SOX9 axis - Bin Li; Haikang Zhao; Jianming Song; Fenglu Wang; Mingsheng Chen (Human Cell, 2020)

Circ_ANKIB1 stabilizes the regulation of miR-19b on SOCS3/STAT3 pathway to promote osteosarcoma cell growth and invasion - Yi-xin Du; Lin-xin Guo; Han-song Pan; Yi-min Liang; Xiang Li (Human Cell, 2020)

LncRNA LINC00857 regulates lung adenocarcinoma progression, apoptosis and glycolysis by targeting miR-1179/SPAG5 axis - Lan Wang; Liqiang Cao; Chunxia Wen; Jie Li; Guiping Yu; Chengying Liu (Human Cell, 2020)

CCND1 silencing suppresses liver cancer stem cell differentiation through inhibiting autophagy - Hongying Zhang (Human Cell, 2020)

Dexmedetomidine alleviates doxorubicin cardiotoxicity by inhibiting mitochondrial reactive oxygen species generation - Jie-Lu Yu; Yi Jin; Xiang-Yuan Cao; Hua-Hua Gu (Human Cell, 2020)

Establishment and characterization of novel patient-derived extraskeletal osteosarcoma cell line NCC-ESOS1-C1 - Fumiko Kito; Rieko Oyama; Rei Noguchi; Emi Hattori; Marimu Sakumoto; Makoto Endo; Eisuke Kobayashi; Akihiko Yoshida; Akira Kawai; Tadashi Kondo (Human Cell, 2020)

LncRNA SNHG8 promotes proliferation and invasion of gastric cancer cells by targeting the miR-491/PDGFRA axis - Peigen Zhang; Suting Li; Zhijun Chen; Yan Lu; Huanyao Zhang (Human Cell, 2020)

LncRNA LINC00470 promotes proliferation through association with NF45/NF90 complex in hepatocellular carcinoma - Wenwei Huang; Juntao Liu; Jijun Yan; Zhengbin Huang; Xiongjie Zhang; Yanping Mao; Xiufang Huang (Human Cell, 2020)

Sphk1 promotes ulcerative colitis via activating JAK2/STAT3 signaling pathway - Jiawen Liu; Bo Jiang (Human Cell, 2020)

MiR-125b-5p suppresses the bladder cancer progression via targeting HK2 and suppressing PI3K/AKT pathway - Shuo Liu; Qin Chen; Yue Wang (Human Cell, 2020)

mTOR inhibitor everolimus reduces invasiveness of melanoma cells - Dorota Ciołczyk-Wierzbicka; Dorota Gil; Marta Zarzycka; Piotr Laidler (Human Cell, 2020)
The mammalian target of rapamycin (mTOR) plays a key role in several cellular processes: proliferation, survival, invasion, and angiogenesis, and therefore, controls cell behavior both in health and in disease. Dysregulation of the mTOR signaling is involved in some of the cancer hallmarks, and thus the mTOR pathway is an important target for the development of a new anticancer therapy. The object of this study is recognition of the possible role of mTOR kinase inhibitors—everolimus single and in combination with selected downstream protein kinases inhibitors: LY294002 (PI3 K), U0126 (ERK1/2), GDC-0879 (B-RAF), AS-703026 (MEK), MK-2206 (AKT), PLX-4032 (B-RRAF) in cell invasion in malignant melanoma. Treatment of melanoma cells with everolimus led to a significant decrease in the level of both phosphorylated: mTOR (Ser2448) and mTOR (Ser2481) as well as their downstream effectors. The use of protein kinase inhibitors produced a significant decrease in metalloproteinases (MMPs) activity, as well as diminished invasion, especially when used in combination. The best results in the inhibition of both MMPs and cell invasiveness were obtained for the combination of an mTOR inhibitor— everolimus with a B-RAF inhibitor—PLX-4032. Slightly less profound reduction of invasiveness was obtained for the combinations of an mTOR inhibitor—everolimus with ERK1/2 inhibitor—U126 or MEK inhibitor—AS-703026 and in the case of MMPs activity decrease for PI3 K inhibitor—LY294002 and AKT inhibitor—MK-2206. The simultaneous use of everolimus or another new generation rapalog with selected inhibitors of crucial signaling kinases seems to be a promising concept in cancer treatment.

LncRNA SNHG3 promotes cell proliferation and invasion through the miR-384/hepatoma-derived growth factor axis in breast cancer - Qiuhong Ma; Xiangqin Qi; Xiaona Lin; Liang Li; Libo Chen; Wei Hu (Human Cell, 2020)

Establishment and characterization of a new malignant peritoneal mesothelioma cell line, KOG-1, from the ascitic fluid of a patient with pemetrexed chemotherapy resistance - Tomoko Akahane; Akira Hirasawa; Issei Imoto; Aki Okubo; Manabu Itoh; Yoshiko Nanki; Tomoko Yoshihama; Eichiro Tominaga; Daisuke Aoki (Human Cell, 2020)

LncRNA NBR2 suppresses migration and invasion of colorectal cancer cells by downregulating miRNA-21 - Jinghui Bai; Jian Xu; Jian Zhao; Rui Zhang (Human Cell, 2020)

HHLA2 overexpression is a novel biomarker of malignant status and poor prognosis in gastric cancer - Li Wei; Liang Tang; Haiyan Chang; Song Huo; Yan Li (Human Cell, 2020)

HOXA11-AS promotes the migration and invasion of hepatocellular carcinoma cells by inhibiting miR-124 expression by binding to EZH2 - Wen-long Zhang; Ya-nan Zhao; Zhang-zhen Shi; Gui-ying Gu; Dan Cong; Chen Wei; Yuan-song Bai (Human Cell, 2019)

MiR-148a inhibits the proliferation and migration of glioblastoma by targeting ITGA9 - Tong-Jiang Xu; Peng Qiu; Yu-Bao Zhang; Sheng-Yuan Yu; Guang-Ming Xu; Wei Yang (Human Cell, 2019)

MiR-202-5p/MATN2 are associated with regulatory T-cells differentiation and function in allergic rhinitis - Li Wang; Xin Yang; Wencai Li; Xicheng Song; Shasha Kang (Human Cell, 2019)

Up-regulation of long non-coding RNA AWPPH inhibits proliferation and invasion of gastric cancer cells via miR-203a/DKK2 axis - Lei Li; Jiguang Kou; Bibo Zhong (Human Cell, 2019)

LncRNA HEIH regulates cell proliferation and apoptosis through miR-4458/SOCS1 axis in triple-negative breast cancer - Peng Li; Bo Zhou; Yuetao Lv; Qian Qian (Human Cell, 2019)

MicroRNA-532 exerts oncogenic functions in t(4;14) multiple myeloma by targeting CAMK2N1 - Kaihong Xu; Xuezhen Hu; Laifang Sun; Qingyue Liang; Guifang Ouyang; Yanli Zhang; Qitian Mu; Xiao Yan (Human Cell, 2019)

Interaction between cancer cells and cancer-associated fibroblasts after cisplatin treatment promotes cancer cell regrowth - Shoshi Hisamitsu; Tomoyuki Miyashita; Hiroko Hashimoto; Shinya Neri; Masato Sugano; Hiroshi Nakamura; Shota Yamazaki; Atsushi Ochiai; Koichi Goto; Masahiro Tsuboi; Genichiro Ishii (Human Cell, 2019)

miR-543 promoted the cell proliferation and invasion of nasopharyngeal carcinoma by targeting the JAM-A - Xue Jiang; Baoqiang Dai; Lichun Feng (Human Cell, 2019)

Long noncoding RNA LINC00460 aggravates invasion and metastasis by targeting miR-30a-3p/Rap1A in nasopharyngeal carcinoma - Xiaodong Hu; Weiwei Liu; Xue Jiang; Bin Wang; Liping Li; Jian Wang; Jinhua Ma (Human Cell, 2019)

Characterization of a new glioblastoma cell line, GB-val4, with unusual TP53 mutation - Lisandra Muñoz-Hidalgo; Teresa San-Miguel; Javier Megías; Rosario Gil-Benso; Miguel Cerdá-Nicolás; Concha López-Ginés (Human Cell, 2019)

LncRNA terminal differentiation-induced ncRNA (TINCR) sponges miR-302 to upregulate cyclin D1 in cervical squamous cell carcinoma (CSCC) - Anli Hou; Yali Zhang; Yi Zheng; Yujuan Fan; Huilan Liu; Xiuying Zhou (Human Cell, 2019)

Bit1-a novel regulator of astrocyte function during retinal development: proliferation, migration, and paracrine effects on vascular endothelial cell - Yan Liu; Jiali Ji; Wanyu Shao; Min Luo; Bo Ma (Human Cell, 2019)

MiR-1261/circ-PTPRZ1/PAK1 pathway regulates glioma cell growth and invasion - Feng Zhang; Shu-rong Mai; Fei-peng Cao; Can-xian Cao; Liang Zhang (Human Cell, 2019)

Involvement of the MDR1 gene and glycolipids in anticancer drug-resistance of human ovarian carcinoma-derived cells - Kyoko Tanaka; Kazushige Kiguchi; Mikio Mikami; Daisuke Aoki; Masao Iwamori (Human Cell, 2019)

The clinical and prognostic significance of paraoxonase-2 in gastric cancer patients: immunohistochemical analysis - Xiaohua Wang; Guifang Xu; Jingyuan Zhang; Shuaiyu Wang; Min Ji; Lei Mo; Mengxia Zhu; Jun Li; Guoren Zhou; Jianwei Lu; Cheng Chen (Human Cell, 2019)

Sulforaphane inhibits the activation of hepatic stellate cell by miRNA-423-5p targeting suppressor of fused - Ming-Hui Feng; Jian-Wei Li; Hai-Tao Sun; Song-Qi He; Jie Pang (Human Cell, 2019)

MiR-142-3p suppresses the proliferation, migration and invasion through inhibition of NR2F6 in lung adenocarcinoma - Chang’e Jin; Liang Xiao; Zeqiang Zhou; Yan Zhu; Geng Tian; Shuhua Ren (Human Cell, 2019)

miRNA-21 promotes cell proliferation and invasion via VHL/PI3K/AKT in papillary thyroid carcinoma - Chuanshan Zang; Jian Sun; Wenyi Liu; Chunqin Chu; Liwei Jiang; Ruifeng Ge (Human Cell, 2019)

Inhibition of angiotensin II-induced cerebrovascular smooth muscle cell proliferation by LRRC8A downregulation through suppressing PI3K/AKT activation - Jingjing Lu; Feng Xu; Jiewen Zhang (Human Cell, 2019)

Dihydrotestosterone increases the risk of bladder cancer in men - Dorota Gil; Marta Zarzycka; Joanna Dulińska-Litewka; Dorota Ciołczyk-Wierzbicka; Małgorzata Lekka; Piotr Laidler (Human Cell, 2019)

ADRB2 suppresses IL-13-induced allergic rhinitis inflammatory cytokine regulated by miR-15a-5p - Li Wang; Qiaoying Lv; Xicheng Song; Kun Jiang; Junhong Zhang (Human Cell, 2019)

Function of innate lymphoid cells in the immune-related disorders - Tanja Dzopalić; Biljana Božić-Nedeljković; Vladimir Jurišić (Human Cell, 2019)

MicroRNA-30e inhibits proliferation and invasion of non-small cell lung cancer via targeting SOX9 - Yanwei Cui; Lei Zhao; Shilei Zhao; Tao Guo; Fengzhou Li; Zhuoshi Li; Lei Fang; Taihua Wu; Chundong Gu (Human Cell, 2019)

RETRACTED ARTICLE: miR-376a inhibits the proliferation and invasion of osteosarcoma by targeting FBXO11 - Qiaolong Xu; Li Cheng; Jianyang Chen; Wenjie Lu; Peinian Wang (Human Cell, 2019)

ClC-5 alleviates renal fibrosis in unilateral ureteral obstruction mice - Shi-Xia Yang; Zheng-Chang Zhang; Hui-Ling Bai (Human Cell, 2019)

Inhibitor of ghrelin receptor reverses gefitinib resistance in lung cancer - Xiaoyou Li; Xia Zhao; Chenchen Li; Siwen Liu; Fei Yan; Yue Teng; Jifeng Feng; Dengshun Miao (Human Cell, 2019)

PGC-1α protects against oxidized low-density lipoprotein and luteinizing hormone-induced granulosa cells injury through ROS-p38 pathway - Ying Liu; Jianjun Zhai; Jing Chen; Xiaomin Wang; Tingru Wen (Human Cell, 2019)

Correction to: Three-dimensional bone formation including vascular networks derived from dental pulp stem cells in vitro - Miho Watanabe; Akihiro Ohyama; Hiroshi Ishikawa; Akira Tanaka (Human Cell, 2019)

Stem cells in human breast milk - Natalia Ninkina; Michail S. Kukharsky; Maria V. Hewitt; Ekaterina A. Lysikova; Larissa N. Skuratovska; Alexey V. Deykin; Vladimir L. Buchman (Human Cell, 2019)

Proliferation of poorly differentiated endometrial cancer cells through autocrine activation of FGF receptor and HES1 expression - Michihiro Mori; Toshinori Mori; Aina Yamamoto; Shoji Takagi; Masatsugu Ueda (Human Cell, 2019)

Classical differentiation protocols upregulate the expression of the axon guidance genes PLXNA2 and SEMA3C in SH-SY5Y neuroblastoma cells - Ivan Presta; Annalidia Donato; Natalia Malara; Emilio Russo; Marta Letizia Hribal; Giuseppe Donato (Human Cell, 2019)

Pathophysiological significance of clock genes BMAL1 and PER2 as erythropoietin-controlling factors in acute blood hemorrhage - Naoto Tani; Tomoya Ikeda; Yayoi Aoki; Alissa Shida; Shigeki Oritani; Takaki Ishikawa (Human Cell, 2019)

MiR-1179 inhibits the proliferation of gastric cancer cells by targeting HMGB1 - Yongsheng Li; Ce Qin (Human Cell, 2019)

miR-501 acts as an independent prognostic factor that promotes the epithelial–mesenchymal transition through targeting JDP2 in hepatocellular carcinoma - Weixuan Yu; Wen Deng; Qiang Zhao; Hongkai Zhuang; Chuanzhao Zhang; Zhixiang Jian (Human Cell, 2019)

Schlafen 12 mediates the effects of butyrate and repetitive mechanical deformation on intestinal epithelial differentiation in human Caco-2 intestinal epithelial cells - Lakshmi S. Chaturvedi; Qinggang Wang; Shyam K. More; Emilie E. Vomhof-DeKrey; Marc D. Basson (Human Cell, 2019)

The lncRNA UNC5B-AS1 promotes proliferation, migration, and invasion in papillary thyroid cancer cell lines - Yinghao Wang; Adheesh Bhandari; Jizhao Niu; Fan Yang; Erjie Xia; Zhihan Yao; Yixiang Jin; Zhouci Zheng; Shixu Lv; Ouchen Wang (Human Cell, 2019)

Down-regulation of miR-377 suppresses high glucose and hypoxia-induced angiogenesis and inflammation in human retinal endothelial cells by direct up-regulation of target gene SIRT1 - Chunmei Cui; Yuehua Li; Ying Liu (Human Cell, 2019)

Evodiamine ameliorates paclitaxel-induced neuropathic pain by inhibiting inflammation and maintaining mitochondrial anti-oxidant functions - Peipei Wu; Yong Chen (Human Cell, 2019)

SIRT1 promotes GLUT1 expression and bladder cancer progression via regulation of glucose uptake - Jia Chen; Lin Cao; Zhiqiu Li; Yuanwei Li (Human Cell, 2019)

Clinical practice guideline for renal hypouricemia (1st edition) - Akiyoshi Nakayama; Hirotaka Matsuo; Akira Ohtahara; Kazuhide Ogino; Masayuki Hakoda; Toshihiro Hamada; Makoto Hosoyamada; Satoshi Yamaguchi; Ichiro Hisatome; Kimiyoshi Ichida; Nariyoshi Shinomiya (Human Cell, 2019)

Establishment and characterization of a novel dedifferentiated chondrosarcoma cell line, NCC-dCS1-C1 - Rieko Oyama; Fusako Kito; Mami Takahashi; Marimu Sakumoto; Kumiko Shiozawa; Zhiwei Qiao; Rei Noguchi; Takashi Kubo; Shunichi Toki; Fumihiko Nakatani; Akihiko Yoshida; Akira Kawai; et al. (Human Cell, 2019)

Establishment and characterization of a novel cell line, NCC-MFS1-C1, derived from a patient with myxofibrosarcoma - Fusako Kito; Rieko Oyama; Marimu Sakumoto; Kumiko Shiozawa; Zhiwei Qiao; Shunichi Toki; Akihiko Yoshida; Akira Kawai; Tadashi Kondo (Human Cell, 2019)

Age-dependent decline in neurogenesis of the hippocampus and extracellular nucleotides - Yoshinori Takei (Human Cell, 2019)

Suppression of miR-93-5p inhibits high-risk HPV-positive cervical cancer progression via targeting of BTG3 - Jie Li; Zhao-Ping Chu; Hua Han; Yuan Zhang; Fei Tian; Jun-Qin Zhang; Xiang-Hua Huang (Human Cell, 2019)

Enhancement of connexin30.3 expression in mouse embryonic stem cell line EB3 in response to cell–cell contacts - Naruwa Tokunaga; Ryota Kishi; Tomoko Sasai; Mikako Saito (Human Cell, 2019)

Regulation of CCl4-induced liver cirrhosis by hepatically differentiated human dental pulp stem cells - Tomomi Yokoyama; Hiromi Yagi Mendoza; Tomoko Tanaka; Hisataka Ii; Riya Takano; Ken Yaegaki; Hiroshi Ishikawa (Human Cell, 2019)

Alveolus-like organoid from isolated tip epithelium of embryonic mouse lung - Yukihiro Seiji; Takaaki Ito; Yasuko Nakamura; Yuko Nakaishi-Fukuchi; Akira Matsuo; Naruki Sato; Hiroyuki Nogawa (Human Cell, 2019)