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The effect of preference and actual days spent working from home on stress and musculoskeletal pain in older workersNARA Subscribed
Objectives The rapid shift to working from home (WFH) due to the COVID-19 pandemic provided a unique opportunity to examine the relationship between preferred and actual days spent working from home on employees musculoskeletal pain (MSP) and stress in older workers. Methods This study uses three waves of data from the Employees Working from Home (EWFH) study collected in May 2021 ( n = 451), November 2021 ( n = 358) and May 2...
Targeting de novo loss-of-function variants in constrained disease genes improves diagnostic rates in the 100,000 Genomes ProjectNARA Subscribed
Background Genome sequencing was first offered clinically in the UK through the 100,000 Genomes Project (100KGP). Analysis was restricted to predefined gene panels associated with the patient’s phenotype. However, panels rely on clearly characterised phenotypes and risk missing diagnoses outside of the panel(s) applied. We propose a complementary method to rapidly identify pathogenic variants, including those missed by 100KGP...
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