Species outside the Acinetobacter calcoaceticus–baumannii (Acb) complex have recently emerged as new clinically relevant carbapenem-resistant pathogens, such as A. haemolyticus . A new mechanism that could contribute to the dissemination of this resistance is the secretion of outer membrane vesicles (OMVs). We investigate OMVs secreted by A. haemolyticus AN54, a Mexican clinical strain carrying a plasmid-borne bla NDM−1 gene a...

Kelp forests are among the most extensive and productive coastal ecosystems, yet they remain underrepresented in global conservation policy despite widespread declines driven by interacting global- (i.e., ocean warming, marine heatwaves) to local-scale stressors. At the same time, kelp conservation and restoration efforts are expanding rapidly across regions, but measures of success and syntheses tend to primarily focus on eco...

In the Cabo Ortegal Complex, NW Iberia, the subduction-related Variscan (ca. 390 Ma) high-pressure granulites of the Bacariza Formation (Cambrian protolith age, ca. 500 Ma) commonly show banding/regions defined by varying mineral abundance of amphibole and plagioclase-quartz that overprint high-pressure high-temperature (HP-HT) garnet and Na-rich diopsidic clinopyroxene, implying retrogression-related replacements triggered by...

Background Methotrexate (MTX) remains a cornerstone therapy in autoimmune diseases and oncology; however, substantial interindividual variability in efficacy and toxicity persists. While variability in MTX pharmacokinetics (PK) and pharmacodynamics (PD) has been linked to transporters, folate-cycle enzymes, and intracellular polyglutamate accumulation, the contribution of long non-coding RNAs (lncRNAs) as regulatory modifiers...

This study presents chemical (ED-XRF) and lead isotope (HR-MC-ICP-MS) analyses of 29 bronze axes recovered along the eastern Adriatic coast, offering new insights into the metallurgical background of archaeological types with distinct distribution patterns. The analysed axes date from the Middle to the early Late Bronze Age (17th − 14th centuries BC), a crucial period marked by intensified copper production in emerging Alpine...

Metabolic syndrome (MS) represents a major global health problem affecting a large proportion of the population. The improper management of peripheral carbohydrates and lipids leads to behavioral changes in neurons of the limbic brain. This work studied male rats that received diets high in carbohydrates, lipids, and their combination for ninety days. The study examined how peripheral metabolic changes and hypothalamic-pituita...

Aim To synthesise current understanding of overfitting as a pervasive and often underdiagnosed problem in correlative ecological niche models (ENMs), and to assess its consequences for model interpretation, generalisation and transferability under contemporary data and methodological practices. Location Worldwide. Methods We reviewed the ENM literature, synthesising theoretical and empirical studies that address the detection...

Urbanization, characterized by increased temperatures and habitat fragmentation, poses significant threats to reptile populations. Temperature threatens reptile populations, reducing the available hours of activity; however, the deleterious effects of temperature on sperm integrity have been scarcely investigated. This study investigates the impact of urbanization on the sperm fertility of the mesquite lizard ( Sceloporus gram...

Hypersaline microbial mats at Guerrero Negro harbor a stratified, highly diverse community with diel metabolic changes. While oxygenic photosynthesis and sulfate reduction are the dominant bacterial metabolic processes, methylotrophic methanogenesis is the main archaeal pathway. Although these metabolic processes have been biochemically characterized, the identity and encoded metabolism of the microorganisms have been inferred...