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Purpose The aim of this study is to evaluate the kinematic behavior of mandibular advancement devices (MAD) when opening the mouth, by analyzing the influence of the coupling system between the splits and the patient’s morphology. Methods Seven widely used MADs with different coupling mechanisms have been studied in 21 patients (8 females, 13 males). Using validated mathematical MAD models, one per tested device, the trajector...
In a rapidly warming Arctic, genetic variation might serve to buffer organisms against the effects of environmental change, such as sea ice loss and ocean warming. Yet, this concept remains largely unexplored because comprehensive genome‐wide studies across the full ranges of Arctic marine taxa are rare. Bowhead whales ( Balaena mysticetus ) have a strong association with sea ice and polar water masses, a long history of human...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Chilean Blue Whales: Fidelity to Feeding Areas and Migratory Connectivity With the Eastern Tropical Pacific 1NARA Subscribed
In the Eastern South Pacific (ESP), blue whale ( Balaenoptera musculus subsp.) aggregations have been described for two feeding areas (in northern and southern Chile) and in the Eastern Tropical Pacific (ETP). However, despite the knowledge of these areas, little is known about the seasonal movements of blue whales between them. Comparisons of 1074 individual blue whales, photographed across these regions from 1992 to 2019, re...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...