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Synergistic interaction between lead and cadmium via metal-transporter gene upregulation in miceNARA Subscribed
This study investigated the potential synergistic interactions between Pb and Cd, and assessed the contribution of transporter gene expression to the synergism. Mice were administered varying doses of Pb (15, 30 and 108 mg kg −1 ) or Cd (1, 2 and 3 mg kg −1 ), or a combination of both in the feed. Liver, kidney and bone samples were analyzed for Cd, Pb, Cu, Mn, Zn and Fe concentrations. For treatments exhibiting synergistic ef...
Purpose Residential segregation is recognized as an upstream driver of poor health, yet few studies have evaluated its impact on breast cancer incidence at a local level. We examined associations of neighborhood residential segregation with breast cancer (BC) incidence in the Multiethnic Cohort Study (MEC). Methods Measures of Index of Concentration at the Extremes were developed to assess residential segregation by income, ed...