A. Corey results 183
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Limited sucrose intake produces subregion-specific remodeling of perineuronal nets in the medial prefrontal cortexNARA Subscribed
Despite growing recognition that natural rewards can mitigate stress responses, the underlying neurobiological mechanisms remain poorly understood. Here, we examined whether limited sucrose intake (LSI), a paradigm of repeated natural food reward, induces structural plasticity in parvalbumin-expressing (PV+) interneurons and their perineuronal nets (PNNs) within the medial prefrontal cortex (mPFC), a key region involved in str...
Additively Manufactured Partially Porous PAEK Topologies for Proximal Tibia Revision Cones and SleevesNARA Subscribed
Metaphyseal cones and sleeves are an increasingly common component utilized in revision total knee arthroplasty. These partially porous devices have a high surface area and aim to integrate with cancellous bone of the distal femur and proximal tibia to increase the stability of the implant. Incidences of metal-hypersensitivity and macrophage-stimulated osteolysis have motivated the development of a non-metal alternative in the...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Synergistic Effects of a Microbial Amendment and Crushed Basalt: Soil Geochemical and Microbial ResponsesNARA Subscribed
Over geologic timescales, the natural weathering of silicate minerals in soils and regolith regulates atmospheric CO 2 . Although this process is slow relative to anthropogenic emissions, several strategies have been proposed to accelerate this process for climate mitigation. These include the application of finely‐ground silicate rock to increase mineral surface area (enhanced weathering, EW) and the use of microbes that cata...
Aridification Shaped the Diversification of Bothriembryon Land Snails in a Global Biodiversity HotspotNARA Subscribed
Aim Resolving the spatio‐temporal diversification patterns and systematic relationships of endemic Australian land snails against the backdrop of Neogene aridification through analyses of a combined nuclear and mitochondrial DNA sequence dataset. Location Western Australia. Taxon Mollusca, Stylommatophora, Bothriembryontidae, Bothriembryon. Methods We employed Bayesian Inference and Maximum Likelihood to reconstruct the phylog...
Conservation Arks: Genomic Erosion and Inbreeding in an Abundant Island Population of KoalasNARA Subscribed
The persistence of many threatened species depends on isolated habitat patches such as conservation parks, fenced reserves, and islands. While these ‘conservation arks’ provide refuge from many contemporary threats, they can also pose risks of genetic diversity loss and inbreeding depression, further exacerbating extinction risk. A pertinent example is the Kangaroo Island koala population in South Australia that originated fro...
Aim Efforts to retain and restore forest integrity—the degree to which a forest's structure and function are not modified by humans—are increasingly underpinning global biodiversity conservation efforts. However, there is still much uncertainty around how species respond to changes in forest integrity. Geographically variable responses would have consequences for conservation planning assessments and targeted conservation acti...
Typology of the ecological impacts of biological invasionsNARA Subscribed
When embryos experience different environments than their parents, plasticity can enable the development of alternate phenotypes that confer higher fitness in the new conditions. Temperature-induced plasticity could be especially critical for species that inhabit areas with considerable thermal variation. We studied transcriptional variation in embryos of mangrove rivulus ( Kryptolebias marmoratus )—a self-fertilizing hermaphr...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...