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Following a large earthquake, the sparsely instrumented Southwest Pacific fails to consistently meet the UNESCO-IOC targets for operational tsunami forecasting. We present a method to improve regional distance tsunami early warning for such sparsely instrumented regions to meet 10-minute and 45-minute operational targets by utilizing novel application of seismic array processing and a hybrid approach combining array methods, W...
Red-on-Yellow Queen: Bio-Layer Interferometry Reveals Functional Diversity Within Micrurus Venoms and Toxin Resistance in Prey SpeciesNARA Subscribed
Snakes in the family Elapidae largely produce venoms rich in three-finger toxins (3FTx) that bind to the $$\upalpha _1$$ α 1 subunit of nicotinic acetylcholine receptors (nAChRs), impeding ion channel activity. These neurotoxins immobilize the prey by disrupting muscle contraction. Coral snakes of the genus Micrurus are specialist predators who produce many 3FTx, making them an interesting system for examining the coevolution...
Inhibition of p53-MDM2 binding reduces senescent cell abundance and improves the adaptive responses of skeletal muscle from aged miceNARA Subscribed
Skeletal muscle adaptation to external stimuli, such as regeneration following injury and hypertrophy in response to resistance exercise, are blunted with advanced age. The accumulation of senescent cells, along with defects in myogenic progenitor cell (MPC) proliferation, have been strongly linked as contributing factors to age-associated impairment in muscle adaptation. p53 plays an integral role in all these processes, as u...
The Bolometric Bond Albedo of EnceladusNARA Subscribed