Some aspects of synoptic to subseasonal variability of currents in the southern Japan/East Sea (JES) were investigated using high-resolution current measurements and reanalysis model products. Current measurements were made at multiple moorings containing acoustic Doppler current profilers (ADCPs) deployed during MJES (Mixing in the Japan/East Sea, 2021–2022) and LINKS (Linkages of Asian Marginal Seas, 1999–2000) programs. MJE...

The Trichiuroidea, commonly known as snake mackerels and cutlassfishes, constitute an important component of marine pelagic and demersal fish assemblages. Members of this superfamily exhibit a wide spectrum of body shapes from fusiform to elongate and are currently classified into two families (Gempylidae and Trichiuridae), comprising 26 genera and 73 species. In this study, a new and comprehensive multiple nuclear gene datase...

Diazotrophic cyanobacteria, including those responsible for harmful algal blooms, fix atmospheric dinitrogen (N 2 ) to sustain growth when they are limited by dissolved inorganic nitrogen (DIN) supply. Conventional models fail to accurately predict the timing and magnitude of N 2 fixation, partly because of oversimplified assumptions about diazotrophic species responses to N. We hypothesized that cellular carbon (C) and N woul...

Background Chronic pericarditis is associated with significant cardiovascular morbidity, including atrial fibrillation (AF), heart failure (HF), and stroke. Colchicine is widely used in pericarditis management for its anti-inflammatory effects, but its impact on arrhythmias and other cardiovascular outcomes remains uncertain. Methods We conducted a retrospective observational cohort study using the TriNetX global federated res...

Aging is a major risk factor for disease, and developing effective pharmaceutical interventions to improve healthspan and promote longevity has become a high priority for society. One of the molecular pathways related to longevity in various model organisms revolves around lowering AKT1 levels. This prompted our in silico drug screen for small molecules capable of mimicking the transcriptional effects of AKT1 knockdown. We fou...

Canopy-forming kelp forests act as foundation species that provide a wide range of ecosystem services along temperate coastlines. With climate change, these ecosystems are experiencing changing environmental and biotic conditions; however, the kelp distribution and drivers of change in British Columbia remain largely unexplored. This research aimed to use satellite imagery and environmental data to investigate the spatiotempor...

Timolol maleate (TML) is a beta-blocker drug that is commonly used to lower the intraocular pressure in glaucoma. This study focused on using a 3D printing (3DP) method for the manufacturing of an ocular, implantable, sustained-release drug delivery system (DDS). Polycaprolactone (PCL), and PCL with 5 or 10% TML implants were manufactured using a one-step 3DP process. Their physicochemical characteristics were analysed using l...

Brief introduction: What are microclimates and why are they important? Microclimate science has developed into a global discipline. Microclimate science is increasingly used to understand and mitigate climate and biodiversity shifts. Here, we provide an overview of the current status of microclimate ecology and biogeography in terrestrial ecosystems, and where this field is heading next. Microclimate investigations in ecology...

Purpose Hypolimnetic hypoxia has become increasingly prevalent in stratified water bodies in recent decades due to climate change. One primary sink of dissolved oxygen (DO) is sediment oxygen uptake ( $${J}_{{O}_{2}}$$ J O 2 ). On the water side of the sediment–water interface (SWI), $${J}_{{O}_{2}}$$ J O 2 is controlled by a diffusive boundary layer (DBL), a millimeter-scale layer where molecular diffusion is the primary tran...