A. Neumann results 141
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Direct ultrastructural validation of endocrine cell identity in zebrafish pancreatic isletsNARA Subscribed
The zebrafish is widely used to study glucose homeostasis, diabetes, and endocrine cell plasticity, yet a definitive ultrastructural characterization of adult pancreatic endocrine cell types has remained incomplete. Here, we combined transmission electron microscopy with hormone-specific immunogold labeling to define the ultrastructural characteristics of the major endocrine cell populations in adult zebrafish pancreatic islet...
Mycorrhizal identity and light shape tree seedling biomass responses in plant–soil feedbacksNARA Subscribed
Aims Plant–soil feedbacks (PSFs) are key drivers of forest composition and diversity, yet their direction and magnitude may depend on the mycorrhizal identity of interacting species, environmental conditions, and experimental context. Methods We conducted complementary greenhouse and field experiments using Acer rubrum L., Acer saccharum Marsh., Prunus serotina Ehrh. (all arbuscular mycorrhizal [AM] species), and Quercus alba...
Mirtazapine is an atypical tetracyclic antidepressant drug that binds to several monoamine neurotransmitter receptors. For instance, mirtazapine binds to H 1 -histamine receptors in vitro and in the brain of patients in vivo. Here, we hypothesize that mirtazapine is an antagonist at human cardiac H 1 -histamine receptors. To test this hypothesis, we measured force of contraction in isolated electrically stimulated (1 Hz) left...
Terrigenous inputs link nutrient dynamics to microbial communities in a tropical lagoonNARA Subscribed
Nutrient availability drives community structure and ecosystem processes, especially in tropical lagoons that are typically oligotrophic but often receive allochthonous inputs from land. Terrestrially derived nutrients are introduced to tropical lagoons by surface runoff and submarine groundwater discharge, which are influenced by seasonal precipitation. However, terrigenous inputs presumably diminish along the onshore–offshor...
Predicting the geometrical evolution of the pore space in geological formations due to fluid–solid interactions has applications in reservoir engineering, oil recovery, and geological storage of carbon dioxide. However, modeling frameworks that combine fluid flow with physical and chemical processes at a rock’s pore scale are scarce. Here, we report a method for modeling a rock’s pore space as a network of connected capillarie...
Clozapine is an atypical antipsychotic (neuroleptic) drug. Clozapine binds to H 2 -histamine receptors in vitro. We wanted to test the hypothesis that clozapine might be a functional antagonist at human cardiac H 2 -histamine receptors. To that end, we studied isolated electrically stimulated left atrial preparations and spontaneously beating right atrial preparations from transgenic mice with cardiomyocyte-specific overexpres...
Genome-wide association study of Fuchs’ endothelial corneal dystrophy in the German populationNARA Subscribed
The genetic etiology of Fuchs Endothelial Corneal Dystrophy (FECD) is not yet fully elucidated. While the disease is widespread and the leading indication for corneal transplantation in the Western world, the concurrent shortage of corneal transplants underscores the urgent need for further research into the underlying mechanisms. Such investigations could enable the development of innovative therapeutic strategies. Therefore,...
The SW highlands of Ethiopia are a key component in the evolution of modern humans. Yet, palaeoecological studies, essential to understand past human-vegetation relationships, are almost inexistent in this region. In this paper, we present an anthracological study of the Sodicho rock shelter, located at 1,930 m a.s.l. in the SW Ethiopian Afromontane forest zone, reconstructing the past woody vegetation since the end of the Afr...