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A genome assembly and transcriptome atlas of the inbred Babraham pig to illuminate porcine immunogenetic variationNARA Subscribed
The inbred Babraham pig serves as a valuable biomedical model for research due to its high level of homozygosity, including in the major histocompatibility complex (MHC) loci and likely other important immune-related gene complexes, which are generally highly diverse in outbred populations. As the ability to control for this diversity using inbred organisms is of great utility, we sought to improve this resource by generating...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Host‐pathogen‐environment interactions predict survival outcomes of adult sockeye salmon ( Oncorhynchus nerka ) released from fisheriesNARA Subscribed
Incorporating host‐pathogen(s)‐environment axes into management and conservation planning is critical to preserving species in a warming climate. However, the role pathogens play in host stress resilience remains largely unexplored in wild animal populations. We experimentally characterized how independent and cumulative stressors (fisheries handling, high water temperature) and natural infections affected the health and longe...
A Continental-Scale Validation of Ecosystem Service ModelsNARA Subscribed
Editorial July 2018NARA Subscribed
A three‐phase excess post‐exercise oxygen consumption in Atlantic salmon Salmo salar and its response to exercise trainingNARA Subscribed
The recovery of oxygen uptake to the standard metabolic rate (SMR) following exhaustive chasing exercise in Atlantic salmon Salmo salar parr occurred in three phases (rapid, plateau and slow). The initial recovery phase lasted 0·7 h and contributed 16% to the total excess post‐exercise oxygen consumption (EPOC). It was followed by a longer plateau phase that contributed 53% to the total EPOC. The slow recovery phase that compl...
A rainbow trout Oncorhynchus mykiss strain with higher aerobic scope in normoxia also has superior tolerance of hypoxiaNARA Subscribed
This study compared parr from three strains of rainbow trout Oncorhynchus mykiss to examine intraspecific variation in metabolic traits, hypoxia tolerance and upper thermal tolerance in this species. At the strain level, variation in absolute aerobic scope (AAS), critical oxygen level (O 2crit ), incipient lethal oxygen saturation (ILOS) and critical thermal maximum (CT max ) generally exhibited consistent differences among th...
The macroecology of infectious diseases: a new perspective on global‐scale drivers of pathogen distributions and impactsNARA Subscribed
Identifying drivers of infectious disease patterns and impacts at the broadest scales of organisation is one of the most crucial challenges for modern science, yet answers to many fundamental questions remain elusive. These include what factors commonly facilitate transmission of pathogens to novel host species, what drives variation in immune investment among host species, and more generally what drives global patterns of par...
The primary aim of this long‐term angler‐led tagging programme was to gain information about seasonal changes in distribution of the starry smooth‐hound shark Mustelus asterias , along the Dutch coast for management and conservation purposes. Between 2011 and 2014, M. asterias comprised 92·6% ( n = 2418) of the total elasmobranch catch ( n = 2612) by the licenced group of taggers within the Dutch Delta of which 2244 M. asteria...
A new, image‐based, tritiated ligand technique for measuring cardiac β 2 ‐adrenoceptor (β 2 ‐AR) binding characteristics was developed and validated with adult rainbow trout Oncorhynchus mykiss hearts so that the tissue limitation of traditional receptor binding techniques could be overcome and measurements could be made in hearts nearly 14‐times smaller than previously used. The myocardial cell‐surface (functional) β 2 ‐AR de...
The techniques and protocols used to successfully capture, transport and breed Arctic cod Boreogadus saida , as well as to rear their larvae through to adulthood are summarized. Breeding B. saida will increase the opportunity to study this fish species, which is a critical part of the Arctic food web.
Upper thermal limits of the hearts of Arctic cod Boreogadus saida : adults compared with larvaeNARA Subscribed
Wild adult and reared larval Boreogadus saida were acclimated to 3·5° C before testing their cardiac response to acute warming. Heart rate transition temperatures during warming were similar for adult and larval hearts, except that the maximum temperature for heart rate was 3° C warmer for adults. Thus, in a rapidly warming Arctic Ocean, the upper temperature limit for larval rather than adult B. saida appears more likely to d...
The measurement of specific dynamic action in fishesNARA Subscribed
Specific dynamic action ( SDA ) is the postprandial increase in oxygen uptake. Whereas it is easy to measure in fishes that remain calm and motionless during the entire digestion period, spontaneous locomotor activity is a frequent problem that leads to overestimation of SDA amplitude and magnitude (area under the curve, bound by the standard metabolic rate, SMR ). Few studies have attempted to remove the effect of fish activi...
The determination of standard metabolic rate in fishesNARA Subscribed
This review and data analysis outline how fish biologists should most reliably estimate the minimal amount of oxygen needed by a fish to support its aerobic metabolic rate (termed standard metabolic rate; SMR ). By reviewing key literature, it explains the theory, terminology and challenges underlying SMR measurements in fishes, which are almost always made using respirometry (which measures oxygen uptake, Ṁ O 2 ). Then, the p...