Cerebral blood flow (CBF) deficits, cognitive decline, and brain structural changes have been reported in older adults with and without apolipoprotein E-e4 ( APOE4 )-related risk for dementia. However, it remains unclear whether brain structural changes mediate the effects of hypoperfusion on cognitive impairment in APOE4 carriers and non-carriers. We studied 166 (60–89 years) APOE4 carriers (ε3/ε4 or ε4/ε4) and APOE3 homozygo...

There is growing interest in studying vascular contributions to cognitive impairment and dementia (VCID) and developing biomarkers to identify at-risk individuals. A combination of biofluid and neuroimaging markers may better profile early stage VCID than individual measures. Here, we tested this possibility focusing on plasma levels of S100 calcium-binding protein B (S100B), which has been linked with blood–brain-barrier (BBB...

Resting-state functional connectivity (FC) is suggested to be cross-sectionally associated with both vascular burden and Alzheimer's disease (AD) pathology. For instance, studies in pre-clinical AD subjects have shown increases of cerebral spinal fluid soluble platelet-derived growth factor receptor-β (CSF sPDGFRβ, a marker of BBB breakdown) but have not demonstrated if this vascular impairment affects neuronal dysfunction. It...

Environmental benefits of circular economy (CE) measures, such as waste reduction, need to be weighed against the urgent need to reduce CO 2 emissions to zero, in line with the Paris Agreement climate goals of 1.5–2 °C. Several studies have quantified CO 2 emissions associated with CE measures in the construction sector in different EU countries, with the literature’s focus ranging from bricks and insulation products, to indiv...

Synthetic surfactants are used in several industries, including manufacturing, pharmaceutical and cosmetic’s, food and feed, agriculture, petroleum and environmental remediation for their ability to adsorb to fluid and solid-water interfaces. However, their widespread use and their synthetic preparation through environmentally unfavorable processes counterbalances the value of this class of reagents. This fact has stimulated n...

Coevolution with predators leads to the use of low‐risk habitats by many prey species, which promotes survival during early developmental phases. These nurseries are valued by conservation and management agencies because of their contributions to adult populations. However, the physical and geographic characteristics, like shallow depths and isolation from other marine habitats, that restrict access to predators and thereby re...

Waves overtop berms and seawalls along the shoreline of Imperial Beach (IB), CA when energetic winter swell and high tide coincide. These intermittent, few-hour long events flood low-lying areas and pose a growing inundation risk as sea levels rise. To support city flood response and management, an IB flood warning system was developed. Total water level (TWL) forecasts combine predictions of tides and sea-level anomalies with...