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A task-aligned multimodal machine learning framework for studying working memory dysfunction in Parkinson’s diseaseNARA Subscribed
Cognitive impairment is one of the most functionally debilitating non-motor symptoms in Parkinson's disease (PD). Yet, current diagnostic and clinical practices rely heavily on subjective assessments and burdensome behavioral testing, which lack the temporal resolution to detect subtle deficits. While EEG and pupillometry offer promising non-invasive insights into cognitive processing, more scalable and objective methods are n...
Motivation United States federal biomonitoring programs assess the status of freshwater ecosystems using standardised sampling protocols. While most data from these efforts are publicly available, new users face barriers in applying these data appropriately. Here, we introduce unified assemblage databases for fish and macroinvertebrates in rivers and streams from US federal biomonitoring. These are one of the largest single‐so...
Ecology and mechanisms of brood raiding of Iridomyrmex by the thermophilic ant, Melophorus anderseniNARA Subscribed
Melophorus anderseni is a thermophilic ant species that nests near colonies of Iridomyrmex on which it conducts brood raids. We examined its colony founding behavior and foraging ecology to evaluate possible mechanisms that may facilitate interspecific nest raiding, as well as determine if it is a parasite or specialist predator. Specifically, we (1) examined colony establishment and survival, (2) patterns of worker activity (...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Multiple Community Properties Drive Ecosystem Resistance and Resilience to Extreme Climate Events Across Mesic GrasslandsNARA Subscribed
Ecosystem resistance and resilience to extreme climate events is impacted by community properties, including biodiversity. However, the relative importance of species richness, evenness and dominance is debated and is further modulated by global change factors such as nutrient addition. Using nearly 40 years of data from naturally‐assembled plant communities at three Long‐Term Ecological Research sites, we found that while spe...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Short-term mTOR inhibition by rapamycin improves cardiac and endothelial function in older men: a proof-of concept pilot studyNARA Subscribed
Rapamycin (RAPA) and related mTOR-inhibitors have been shown to enhance healthy aging in animal models (2–10) and to be generally safe and tolerable in older people (11–13). However, studies to assess their effects on specific age-related pathologies in humans are limited. Since improvements in cardiovascular function with RAPA treatment have been reported in preclinical studies (5, 9, 10, 14–17), we posited that RAPA could be...
Solving the sulfur isotope discrepancy in Central AmericaNARA Subscribed
Establishment, current status and possible origin of the greater white-toothed shrew Crocidura russula in Great BritainNARA Subscribed
Great Britain has three native shrews, while the greater white-toothed shrew (GWT: Crocidura russula ) is native to the European continent and some Channel islands. The GWT shrew was first reported in northern England in 2022. We detail its immediate investigation through national authorities, non-government bodies and individuals. Sixteen GWT were among 595 small mammals live-trapped. Barn owl pellet analysis revealed 56 GWT...
Genetic diversity and historical demography of the imperiled rattlesnake-master borer moth (Papaipema eryngii)NARA Subscribed
Large-scale habitat loss and degradation have triggered a global biodiversity crisis with ecological-specialist species at increased risk of extinction. The Rattlesnake-Master Borer ( Papaipema eryngii ) is a small noctuid moth whose larvae feed exclusively on rattlesnake master ( Eryngium yuccifolium ), a native grassland plant ranging throughout the eastern United States. Widespread loss of grassland habitats has resulted in...