The European North-West shelf seas (NWS) support economic interests and provide environmental services to adjacent countries. Expansion of offshore activities, such as renewable energy infrastructure, aquaculture, and growth of international shipping, will place increasingly complex demands on the marine environment over the coming decades. Skilful forecasting of NWS properties on seasonal timescales will help to effectively m...

Key message Three independent experiments with different genetic backgrounds mapped the resistance gene Pm7 in the oat genome to the distal part of the long arm of chromosome 5D. Abstract Resistance of oat to Blumeria graminis DC. f. sp. avenae is an important breeding goal in Central and Western Europe. In this study, the position of the effective and widely used resistance gene Pm7 in the oat genome was determined based on t...

Tides contribute to the large-scale residual circulation and mixing of shelf seas. However, tides are typically excluded from global circulation models (GCMs) so their modelled residual circulation (and mixing) in shelf seas may be systematically wrong. We focus on circulation as it is relatively unexplored, and affects shelf temperature and salinity, potentially biasing climate impact studies. Using a validated model of the N...

Key message Comparative sequence analysis was used to design a SNP marker that aided in the identification of new sources of oat stem rust resistance. Abstract New races of Puccinia graminis f. sp. avenae ( Pga ) threaten global oat production. An A. strigosa accession known to carry the broadly effective oat stem rust resistance gene, Pg6 , was crossed with two susceptible A. strigosa accessions to generate 198 F 2:3 families...

The study of a desmoglein 2 murine model of arrhythmogenic cardiomyopathy revealed cardiac inflammation as a key early event leading to fibrosis. Arrhythmogenic cardiomyopathy (AC) is an inherited heart muscle disorder leading to ventricular arrhythmias and heart failure due to abnormalities in the cardiac desmosome. We examined how loss of desmoglein 2 ( Dsg2 ) in the young murine heart leads to development of AC. Apoptosis w...

Key message Genomic analysis of Mediterranean oats reveals high genetic diversity and three loci for adaptation to this environment. This information together with phenotyping and passport data, gathered in an interactive map, will be a vital resource for oat genetic improvement. Abstract During the twentieth century, oat landraces have increasingly been replaced by modern cultivars, resulting in loss of genetic diversity. How...

The marine biotoxin domoic acid (DA) is an analog of the neurotransmitter glutamate that exerts potent excitatory activity in the brain, heart, and other tissues. Produced by the diatom Pseudo-nitzschia spp., DA accumulates in marine invertebrates, fish, and sediment. Southern sea otters ( Enhydra lutris nereis ) feed primarily on invertebrates, including crabs and bivalves, that concentrate and slowly depurate DA. Due to thei...

We compiled findings from 15 years (1998–2012) of southern sea otter ( Enhydra lutris nereis ) necropsies, incorporating data from 560 animals. Sensitive diagnostic tests were used to detect biotoxins, bacteria, parasites and fungi. Methods to classify primary and contributing causes of death (COD) and sequelae utilized an updated understanding of health risks affecting this population. Several interesting patterns emerged, in...

Variability of Sea-Surface Height (SSH) from ocean dynamic processes is an important component of sea-level change. In this study we dynamically downscale a present-day control simulation of a climate model to replicate sea-level variability in the Northwest European shelf seas. The simulation can reproduce many characteristics of sea-level variability exhibited in tide gauge and satellite altimeter observations. We examine th...

K ATP channels in the vasculature composed of Kir6.1 regulate vascular tone and may contribute to the pathogenesis of endotoxemia. We used mice with cell-specific deletion of Kir6.1 in smooth muscle (smKO) and endothelium (eKO) to investigate this question. We found that smKO mice had a significant survival disadvantage compared with their littermate controls when treated with a sub-lethal dose of lipopolysaccharide (LPS). All...

Changes in ocean properties and circulation lead to a spatially non-uniform pattern of ocean dynamic sea-level change (DSLC). The projections of ocean dynamic sea level presented in the IPCC AR5 were constructed with global climate models (GCMs) from the Coupled Model Intercomparison Project 5 (CMIP5). Since CMIP5 GCMs have a relatively coarse resolution and exclude tides and surges it is unclear whether they are suitable for...

Summary The water column of streams hosts a unique microbial community that is distinct from the microbial communities of the stream benthos and surrounding soil. This community is shaped by complex interacting forces, including microbial dispersal from surrounding environments and in‐stream selection. However, how the processes structuring stream communities change over space and time remains poorly understood. In this study,...