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Poison centers (PCs) in Germany are medical facilities that serve as points of contact for cases of poisoning or suspected poisoning and are available by phone 24 h a day. Consultations are provided by physicians who have completed specialized training in toxicology. Members of the public, healthcare professionals, and institutions with questions regarding toxicology can seek advice from the PCs. Over-the-counter medicines pla...
Challenges, pitfalls, and potential solutions in assessing status and trends of Spheniscus penguinsOA Marine
Reliable, up-to-date assessments of population status and trends are essential for effective conservation. For the four Spheniscus penguin species, these are often undermined by methodological and logistical constraints due to their unique breeding ecology (e.g., burrow nesting and asynchronous breeding). As a result, no single survey method is universally applicable across the genus. Moreover, uneven sampling effort, inconsis...
Physiological and Proteomic Shifts in Pfaffia glomerata Under Drought and Elevated CO₂NARA Subscribed
Drought is a major constraint to plant growth and productivity, and rising atmospheric CO₂ concentrations are expected to modify plant responses to water limitation. However, how CO₂ enrichment reshapes the physiological, metabolic, and molecular regulation of specialized metabolite production under drought remains poorly understood. Here, we investigated the combined effects of elevated CO₂ (e[CO₂]) and drought on plant morph...
Characterization of recharge components for delineation of a high-alpine rock glacier spring catchment, Ötztal Alps (northern Italy)NARA Subscribed
Rock glaciers provide shallow groundwater reservoirs that affect the hydrology of alpine headwater catchments. However, quantifying and identifying their temporally dominating recharge components, as well as delineating their hydrological catchment, can be challenging. The present study makes use of a lumped-parameter rainfall-runoff model (GR4J-CemaNeige) to tackle these issues, applied at a test site in the Ötztal Alps (nort...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Using ground-based lidar data to investigate the water–vapor budget in the daytime atmospheric boundary layerNARA Subscribed
The moisture advection term in the water–vapor budget equation is investigated with a combination of a vertically-staring water–vapor lidar and Doppler lidar systems. These instruments make it possible to get the mean profile of moisture tendency and the latent heat flux (LHF) divergence. We use data of the Land–Atmosphere Feedback Experiment (LAFE) at the Atmospheric Radiation Measurement (ARM) Program’s Southern Great Plains...
State‐Specific Extraction of Environmental DNA : Spike‐and‐Recovery Controls to Validate and Optimise Extraction ProtocolsNARA Subscribed
Getting insights into the quantitative and qualitative contribution of different DNA states, i.e., extracellular (exDNA) and intracellular DNA (iDNA), to the total environmental DNA (eDNA) pool requires reliable methods for their separation. Even though a multitude of respective extraction protocols has been published, their validation is often missing. Here, we selected four protocols for the state‐specific extraction of eDNA...
Background Low energy intake (LEA), eating disorders (ED), and relative energy deficiency syndrome in sport (REDs) lead to negative consequences, such as reduced performance and health among competitive athletes (cA). The aim of this study is to implement recommended screening tools by the International Olympic Committee at mandatory annual preparticipation screening (PPS) in Germany. Methods Young cA are screened with the low...
Laminaria rodriguezii is a rare deep-water kelp species, endemic to the Mediterranean Sea, known in only 19 locations, 5 along the Eastern Provence and 14 in Corsica (French coasts). Populations are found at depths ranging from 48 to 100 m; the oldest record dates back to 1954. This study aims to better understand its distribution, biology, and ecology by analyzing recent data from in situ observations and sampling. In July 20...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Tracking Different States of Spiked Environmental DNA Using Multiplex Digital PCR AssaysNARA Subscribed
The study of microbial communities based on the total environmental DNA (eDNA) is influenced by the presence of different eDNA states, i.e., intracellular (iDNA) and extracellular DNA (exDNA), and the choice of the DNA extraction method. Although the use of spike‐and‐recovery controls facilitates the diagnosis of such issues, appropriate experimental setups simultaneously accounting for the different eDNA states and their bact...
Molecular analysis confirms Agama picticauda invasion on Western Indian Ocean islandsNARA Subscribed
The Western Indian Ocean biodiversity hotspot hosts a remarkable array of endemic species, but invasive alien species increasingly threaten its unique ecosystems. Lizards of the West African Agama agama species group are successful colonizers, with recent introductions to Grande Comore (Comoros Archipelago) and Reunion Island. Systematic revisions within the native range of the A. agama species group have left many of the intr...